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UniProtKB - Q14444 (CAPR1_HUMAN)

Entry version 177 (02 Jun 2021)
Sequence version 2 (08 Apr 2008)
Previous versions | rss
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Protein

Caprin-1

Gene

CAPRIN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May regulate the transport and translation of mRNAs of proteins involved in synaptic plasticity in neurons and cell proliferation and migration in multiple cell types. Binds directly and selectively to MYC and CCND2 RNAs. In neuronal cells, directly binds to several mRNAs associated with RNA granules, including BDNF, CAMK2A, CREB1, MAP2, NTRK2 mRNAs, as well as to GRIN1 and KPNB1 mRNAs, but not to rRNAs.

1 Publication

Miscellaneous

Overexpression induces the formation of cytoplasmic stress granules and EIF2A phosphorylation through a mechanism that depends on its ability to bind mRNA.

Caution

Was originally thought to be a GPI-anchored membrane protein.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionProtein synthesis inhibitor, RNA-binding
Biological processDifferentiation

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q14444

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q14444

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Caprin-1
Alternative name(s):
Cell cycle-associated protein 1
Cytoplasmic activation- and proliferation-associated protein 1
GPI-anchored membrane protein 1
GPI-anchored protein p137
Short name:
GPI-p137
Short name:
p137GPI
Membrane component chromosome 11 surface marker 1
RNA granule protein 105
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CAPRIN1
Synonyms:GPIAP1, GPIP137, M11S1, RNG105
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:6743, CAPRIN1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		601178, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q14444

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000135387.19

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell projection, Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi612R → A: Major reduction in MYC and CCND2 RNA-binding; when associated with A-633 and A-690. 1 Publication1
Mutagenesisi633R → A: Major reduction in MYC and CCND2 RNA-binding; when associated with A-612 and A-690. 1 Publication1
Mutagenesisi690R → A: Major reduction in MYC and CCND2 RNA-binding; when associated with A-612 and A-633. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		4076

Open Targets

More...OpenTargetsi		ENSG00000135387

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA30508

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q14444, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL4295821

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		CAPRIN1

Domain mapping of disease mutations (DMDM)

More...DMDMi		182676426

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000875492 – 709Caprin-1Add BLAST708

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylprolineCombined sources1
Modified residuei10PhosphoserineCombined sources1
Modified residuei115PhosphoserineCombined sources1
Modified residuei165Omega-N-methylarginineBy similarity1
Modified residuei335PhosphoserineCombined sources1
Modified residuei343PhosphoserineCombined sources1
Modified residuei626Omega-N-methylarginineCombined sources1
Modified residuei633Omega-N-methylarginineCombined sources1
Modified residuei640Omega-N-methylarginineCombined sources1
Modified residuei698Asymmetric dimethylarginine; alternateCombined sources1
Modified residuei698Omega-N-methylarginine; alternateCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

O-glycosylated (O-GlcNAcylated), in a cell cycle-dependent manner.1 Publication

Keywords - PTMi

Acetylation, Glycoprotein, Methylation, Phosphoprotein

Proteomic databases

The CPTAC Assay portal

More...CPTACi		CPTAC-37
CPTAC-38

Encyclopedia of Proteome Dynamics

More...EPDi		Q14444

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q14444

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q14444

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q14444

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q14444

PeptideAtlas

More...PeptideAtlasi		Q14444

PRoteomics IDEntifications database

More...PRIDEi		Q14444

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		59992 [Q14444-1]
59993 [Q14444-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q14444

MetOSite database of methionine sulfoxide sites

More...MetOSitei		Q14444

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q14444

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q14444

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000135387, Expressed in testis and 249 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q14444, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q14444, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000135387, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

May form homomultimers (PubMed:14764709).

Interacts with G3BP1; interaction is direct and takes place in cytoplasmic RNA granules (PubMed:17210633).

Interacts with PQBP1 (PubMed:21933836).

Interacts with DDX3X (PubMed:28733330).

4 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		110252, 184 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q14444

Protein interaction database and analysis system

More...IntActi		Q14444, 52 interactors

Molecular INTeraction database

More...MINTi		Q14444

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000340329

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q14444, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1709
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q14444

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 50DisorderedSequence analysisAdd BLAST50
Regioni260 – 291DisorderedSequence analysisAdd BLAST32
Regioni360 – 381G3BP1-bindingAdd BLAST22
Regioni417 – 446DisorderedSequence analysisAdd BLAST30
Regioni475 – 499DisorderedSequence analysisAdd BLAST25
Regioni524 – 709DisorderedSequence analysisAdd BLAST186

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili60 – 94Sequence analysisAdd BLAST35
Coiled coili125 – 153Sequence analysisAdd BLAST29

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 22Polar residuesSequence analysisAdd BLAST22
Compositional biasi274 – 288Acidic residuesSequence analysisAdd BLAST15
Compositional biasi532 – 609Polar residuesSequence analysisAdd BLAST78
Compositional biasi641 – 679Polar residuesSequence analysisAdd BLAST39

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the caprin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QUGC, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000153438

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q14444

Identification of Orthologs from Complete Genome Data

More...OMAi		VEQNYFK

Database of Orthologous Groups

More...OrthoDBi		382856at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q14444

TreeFam database of animal gene trees

More...TreeFami		TF329471

Family and domain databases

Intrinsically Disordered proteins with Extensive Annotations and Literature

More...IDEALi		IID00668

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR028816, Caprin
IPR022070, Caprin-1_C
IPR041637, Caprin-1_dimer

The PANTHER Classification System

More...PANTHERi		PTHR22922, PTHR22922, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF12287, Caprin-1_C, 1 hit
PF18293, Caprin-1_dimer, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q14444-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPSATSHSGS GSKSSGPPPP SGSSGSEAAA GAGAAAPASQ HPATGTGAVQ 
        60         70         80         90        100
TEAMKQILGV IDKKLRNLEK KKGKLDDYQE RMNKGERLNQ DQLDAVSKYQ 
       110        120        130        140        150
EVTNNLEFAK ELQRSFMALS QDIQKTIKKT ARREQLMREE AEQKRLKTVL 
       160        170        180        190        200
ELQYVLDKLG DDEVRTDLKQ GLNGVPILSE EELSLLDEFY KLVDPERDMS 
       210        220        230        240        250
LRLNEQYEHA SIHLWDLLEG KEKPVCGTTY KVLKEIVERV FQSNYFDSTH 
       260        270        280        290        300
NHQNGLCEEE EAASAPAVED QVPEAEPEPA EEYTEQSEVE STEYVNRQFM 
       310        320        330        340        350
AETQFTSGEK EQVDEWTVET VEVVNSLQQQ PQAASPSVPE PHSLTPVAQA 
       360        370        380        390        400
DPLVRRQRVQ DLMAQMQGPY NFIQDSMLDF ENQTLDPAIV SAQPMNPTQN 
       410        420        430        440        450
MDMPQLVCPP VHSESRLAQP NQVPVQPEAT QVPLVSSTSE GYTASQPLYQ 
       460        470        480        490        500
PSHATEQRPQ KEPIDQIQAT ISLNTDQTTA SSSLPAASQP QVFQAGTSKP 
       510        520        530        540        550
LHSSGINVNA APFQSMQTVF NMNAPVPPVN EPETLKQQNQ YQASYNQSFS 
       560        570        580        590        600
SQPHQVEQTE LQQEQLQTVV GTYHGSPDQS HQVTGNHQQP PQQNTGFPRS 
       610        620        630        640        650
NQPYYNSRGV SRGGSRGARG LMNGYRGPAN GFRGGYDGYR PSFSNTPNSG 
       660        670        680        690        700
YTQSQFSAPR DYSGYQRDGY QQNFKRGSGQ SGPRGAPRGR GGPPRPNRGM 

PQMNTQQVN
Length:709
Mass (Da):78,366
Last modified:April 8, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i56F5BC188CA3A2D4
GO
Isoform 2 (identifier: Q14444-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     690-709: RGGPPRPNRGMPQMNTQQVN → NILWW

Show »
Length:694
Mass (Da):76,862
Checksum:iA908B217A6B88D5C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V153G3V153_HUMAN
Caprin-1
CAPRIN1 GPIAP1, hCG_27570
628Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PLA9E9PLA9_HUMAN
Caprin-1
CAPRIN1
186Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAA61751 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAA88096 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti370Y → D in CAA88096 (PubMed:7657653).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_042425263A → D1 PublicationCorresponds to variant dbSNP:rs1132973Ensembl.1
Natural variantiVAR_042426588Q → H. Corresponds to variant dbSNP:rs12282627Ensembl.1
Natural variantiVAR_042427616R → H. Corresponds to variant dbSNP:rs11552285Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_032687690 – 709RGGPP…TQQVN → NILWW in isoform 2. CuratedAdd BLAST20

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
Z48042 mRNA Translation: CAA88096.1 Frameshift.
AC090469 Genomic DNA No translation available.
CH471064 Genomic DNA Translation: EAW68177.1
CH471064 Genomic DNA Translation: EAW68178.1
CH471064 Genomic DNA Translation: EAW68179.1
BC001731 mRNA Translation: AAH01731.2
X89572 Genomic DNA Translation: CAA61751.1 Sequence problems.
BK001101 mRNA Translation: DAA01118.1
BK001104 mRNA Translation: DAA01121.1
BR000867 mRNA Translation: FAA00692.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS31453.1 [Q14444-1]
CCDS31454.1 [Q14444-2]

Protein sequence database of the Protein Information Resource

More...PIRi		A57352

NCBI Reference Sequences

More...RefSeqi		NP_005889.3, NM_005898.4 [Q14444-1]
NP_976240.1, NM_203364.2 [Q14444-2]
XP_016873238.1, XM_017017749.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000341394; ENSP00000340329; ENSG00000135387 [Q14444-1]
ENST00000389645; ENSP00000374296; ENSG00000135387 [Q14444-2]
ENST00000530820; ENSP00000434204; ENSG00000135387 [Q14444-2]
ENST00000532820; ENSP00000434150; ENSG00000135387 [Q14444-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		4076

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:4076

UCSC genome browser

More...UCSCi		uc001mvg.4, human [Q14444-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z48042 mRNA Translation: CAA88096.1 Frameshift.
AC090469 Genomic DNA No translation available.
CH471064 Genomic DNA Translation: EAW68177.1
CH471064 Genomic DNA Translation: EAW68178.1
CH471064 Genomic DNA Translation: EAW68179.1
BC001731 mRNA Translation: AAH01731.2
X89572 Genomic DNA Translation: CAA61751.1 Sequence problems.
BK001101 mRNA Translation: DAA01118.1
BK001104 mRNA Translation: DAA01121.1
BR000867 mRNA Translation: FAA00692.1
CCDSiCCDS31453.1 [Q14444-1]
CCDS31454.1 [Q14444-2]
PIRiA57352
RefSeqiNP_005889.3, NM_005898.4 [Q14444-1]
NP_976240.1, NM_203364.2 [Q14444-2]
XP_016873238.1, XM_017017749.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4WBEX-ray2.05A/B/C132-251[»]
4WBPX-ray2.50A/B132-251[»]
SMRiQ14444
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi110252, 184 interactors
CORUMiQ14444
IntActiQ14444, 52 interactors
MINTiQ14444
STRINGi9606.ENSP00000340329

Chemistry databases

ChEMBLiCHEMBL4295821

PTM databases

iPTMnetiQ14444
MetOSiteiQ14444
PhosphoSitePlusiQ14444
SwissPalmiQ14444

Genetic variation databases

BioMutaiCAPRIN1
DMDMi182676426

Proteomic databases

CPTACiCPTAC-37
CPTAC-38
EPDiQ14444
jPOSTiQ14444
MassIVEiQ14444
MaxQBiQ14444
PaxDbiQ14444
PeptideAtlasiQ14444
PRIDEiQ14444
ProteomicsDBi59992 [Q14444-1]
59993 [Q14444-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		12960, 307 antibodies

The DNASU plasmid repository

More...DNASUi		4076

Genome annotation databases

EnsembliENST00000341394; ENSP00000340329; ENSG00000135387 [Q14444-1]
ENST00000389645; ENSP00000374296; ENSG00000135387 [Q14444-2]
ENST00000530820; ENSP00000434204; ENSG00000135387 [Q14444-2]
ENST00000532820; ENSP00000434150; ENSG00000135387 [Q14444-1]
GeneIDi4076
KEGGihsa:4076
UCSCiuc001mvg.4, human [Q14444-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		4076
DisGeNETi4076

GeneCards: human genes, protein and diseases

More...GeneCardsi		CAPRIN1
HGNCiHGNC:6743, CAPRIN1
HPAiENSG00000135387, Low tissue specificity
MIMi601178, gene
neXtProtiNX_Q14444
OpenTargetsiENSG00000135387
PharmGKBiPA30508
VEuPathDBiHostDB:ENSG00000135387.19

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502QUGC, Eukaryota
GeneTreeiENSGT00940000153438
InParanoidiQ14444
OMAiVEQNYFK
OrthoDBi382856at2759
PhylomeDBiQ14444
TreeFamiTF329471

Enzyme and pathway databases

PathwayCommonsiQ14444
SIGNORiQ14444

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		4076, 56 hits in 997 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		CAPRIN1, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		CAPRIN1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		4076
PharosiQ14444, Tbio

Protein Ontology

More...PROi		PR:Q14444
RNActiQ14444, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000135387, Expressed in testis and 249 other tissues
ExpressionAtlasiQ14444, baseline and differential
GenevisibleiQ14444, HS

Family and domain databases

IDEALiIID00668
InterProiView protein in InterPro
IPR028816, Caprin
IPR022070, Caprin-1_C
IPR041637, Caprin-1_dimer
PANTHERiPTHR22922, PTHR22922, 1 hit
PfamiView protein in Pfam
PF12287, Caprin-1_C, 1 hit
PF18293, Caprin-1_dimer, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCAPR1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q14444
Secondary accession number(s): A6NMY7
, D3DR06, Q15074, Q6IMN4, Q6IMN7, Q9BV09
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: April 8, 2008
Last modified: June 2, 2021
This is version 177 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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