UniProtKB - Q14444 (CAPR1_HUMAN)
Protein
Caprin-1
Gene
CAPRIN1
Organism
Homo sapiens (Human)
Status
Functioni
May regulate the transport and translation of mRNAs of proteins involved in synaptic plasticity in neurons and cell proliferation and migration in multiple cell types. Binds directly and selectively to MYC and CCND2 RNAs. In neuronal cells, directly binds to several mRNAs associated with RNA granules, including BDNF, CAMK2A, CREB1, MAP2, NTRK2 mRNAs, as well as to GRIN1 and KPNB1 mRNAs, but not to rRNAs.1 Publication
Miscellaneous
Overexpression induces the formation of cytoplasmic stress granules and EIF2A phosphorylation through a mechanism that depends on its ability to bind mRNA.
Caution
Was originally thought to be a GPI-anchored membrane protein.1 Publication
GO - Molecular functioni
- RNA binding Source: UniProtKB
GO - Biological processi
- negative regulation of translation Source: UniProtKB
- positive regulation of dendrite morphogenesis Source: UniProtKB
- positive regulation of dendritic spine morphogenesis Source: UniProtKB
Keywordsi
Molecular function | Protein synthesis inhibitor, RNA-binding |
Biological process | Differentiation |
Enzyme and pathway databases
PathwayCommonsi | Q14444 |
SIGNORi | Q14444 |
Names & Taxonomyi
Protein namesi | Recommended name: Caprin-1Alternative name(s): Cell cycle-associated protein 1 Cytoplasmic activation- and proliferation-associated protein 1 GPI-anchored membrane protein 1 GPI-anchored protein p137 Short name: GPI-p137 Short name: p137GPI Membrane component chromosome 11 surface marker 1 RNA granule protein 105 |
Gene namesi | Name:CAPRIN1 Synonyms:GPIAP1, GPIP137, M11S1, RNG105 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:6743, CAPRIN1 |
MIMi | 601178, gene |
neXtProti | NX_Q14444 |
VEuPathDBi | HostDB:ENSG00000135387.19 |
Subcellular locationi
Cytoplasm and Cytosol
- cytosol 1 Publication
Other locations
- dendrite By similarity
- lamellipodium 1 Publication
Note: Associated with RNA granules. At the leading edge of migrating fibroblasts, colocalizes with DDX3X (PubMed:28733330).1 Publication
Cytosol
- cytosol Source: HPA
Other locations
- cell leading edge Source: UniProtKB
- cytoplasm Source: UniProtKB
- cytoplasmic stress granule Source: UniProtKB
- dendrite Source: UniProtKB-SubCell
- lamellipodium Source: UniProtKB-SubCell
- membrane Source: UniProtKB
- P-body Source: UniProtKB
- synapse Source: Ensembl
Keywords - Cellular componenti
Cell projection, CytoplasmPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 612 | R → A: Major reduction in MYC and CCND2 RNA-binding; when associated with A-633 and A-690. 1 Publication | 1 | |
Mutagenesisi | 633 | R → A: Major reduction in MYC and CCND2 RNA-binding; when associated with A-612 and A-690. 1 Publication | 1 | |
Mutagenesisi | 690 | R → A: Major reduction in MYC and CCND2 RNA-binding; when associated with A-612 and A-633. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 4076 |
OpenTargetsi | ENSG00000135387 |
PharmGKBi | PA30508 |
Miscellaneous databases
Pharosi | Q14444, Tbio |
Chemistry databases
ChEMBLi | CHEMBL4295821 |
Genetic variation databases
BioMutai | CAPRIN1 |
DMDMi | 182676426 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000087549 | 2 – 709 | Caprin-1Add BLAST | 708 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylprolineCombined sources | 1 | |
Modified residuei | 10 | PhosphoserineCombined sources | 1 | |
Modified residuei | 115 | PhosphoserineCombined sources | 1 | |
Modified residuei | 165 | Omega-N-methylarginineBy similarity | 1 | |
Modified residuei | 335 | PhosphoserineCombined sources | 1 | |
Modified residuei | 343 | PhosphoserineCombined sources | 1 | |
Modified residuei | 626 | Omega-N-methylarginineCombined sources | 1 | |
Modified residuei | 633 | Omega-N-methylarginineCombined sources | 1 | |
Modified residuei | 640 | Omega-N-methylarginineCombined sources | 1 | |
Modified residuei | 698 | Asymmetric dimethylarginine; alternateCombined sources | 1 | |
Modified residuei | 698 | Omega-N-methylarginine; alternateCombined sources | 1 |
Post-translational modificationi
O-glycosylated (O-GlcNAcylated), in a cell cycle-dependent manner.1 Publication
Keywords - PTMi
Acetylation, Glycoprotein, Methylation, PhosphoproteinProteomic databases
CPTACi | CPTAC-37 CPTAC-38 |
EPDi | Q14444 |
jPOSTi | Q14444 |
MassIVEi | Q14444 |
MaxQBi | Q14444 |
PaxDbi | Q14444 |
PeptideAtlasi | Q14444 |
PRIDEi | Q14444 |
ProteomicsDBi | 59992 [Q14444-1] 59993 [Q14444-2] |
PTM databases
iPTMneti | Q14444 |
MetOSitei | Q14444 |
PhosphoSitePlusi | Q14444 |
SwissPalmi | Q14444 |
Expressioni
Tissue specificityi
Ubiquitous.
Gene expression databases
Bgeei | ENSG00000135387, Expressed in testis and 248 other tissues |
ExpressionAtlasi | Q14444, baseline and differential |
Genevisiblei | Q14444, HS |
Organism-specific databases
HPAi | ENSG00000135387, Low tissue specificity |
Interactioni
Subunit structurei
Protein-protein interaction databases
BioGRIDi | 110252, 183 interactors |
CORUMi | Q14444 |
IntActi | Q14444, 52 interactors |
MINTi | Q14444 |
STRINGi | 9606.ENSP00000340329 |
Miscellaneous databases
RNActi | Q14444, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q14444 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 360 – 381 | G3BP1-bindingAdd BLAST | 22 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 60 – 94 | Sequence analysisAdd BLAST | 35 | |
Coiled coili | 125 – 153 | Sequence analysisAdd BLAST | 29 |
Sequence similaritiesi
Belongs to the caprin family.Curated
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | ENOG502QUGC, Eukaryota |
GeneTreei | ENSGT00940000153438 |
InParanoidi | Q14444 |
OMAi | VEQNYFK |
OrthoDBi | 382856at2759 |
PhylomeDBi | Q14444 |
TreeFami | TF329471 |
Family and domain databases
IDEALi | IID00668 |
InterProi | View protein in InterPro IPR028816, Caprin IPR022070, Caprin-1_C IPR041637, Caprin-1_dimer |
PANTHERi | PTHR22922, PTHR22922, 1 hit |
Pfami | View protein in Pfam PF12287, Caprin-1_C, 1 hit PF18293, Caprin-1_dimer, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q14444-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MPSATSHSGS GSKSSGPPPP SGSSGSEAAA GAGAAAPASQ HPATGTGAVQ
60 70 80 90 100
TEAMKQILGV IDKKLRNLEK KKGKLDDYQE RMNKGERLNQ DQLDAVSKYQ
110 120 130 140 150
EVTNNLEFAK ELQRSFMALS QDIQKTIKKT ARREQLMREE AEQKRLKTVL
160 170 180 190 200
ELQYVLDKLG DDEVRTDLKQ GLNGVPILSE EELSLLDEFY KLVDPERDMS
210 220 230 240 250
LRLNEQYEHA SIHLWDLLEG KEKPVCGTTY KVLKEIVERV FQSNYFDSTH
260 270 280 290 300
NHQNGLCEEE EAASAPAVED QVPEAEPEPA EEYTEQSEVE STEYVNRQFM
310 320 330 340 350
AETQFTSGEK EQVDEWTVET VEVVNSLQQQ PQAASPSVPE PHSLTPVAQA
360 370 380 390 400
DPLVRRQRVQ DLMAQMQGPY NFIQDSMLDF ENQTLDPAIV SAQPMNPTQN
410 420 430 440 450
MDMPQLVCPP VHSESRLAQP NQVPVQPEAT QVPLVSSTSE GYTASQPLYQ
460 470 480 490 500
PSHATEQRPQ KEPIDQIQAT ISLNTDQTTA SSSLPAASQP QVFQAGTSKP
510 520 530 540 550
LHSSGINVNA APFQSMQTVF NMNAPVPPVN EPETLKQQNQ YQASYNQSFS
560 570 580 590 600
SQPHQVEQTE LQQEQLQTVV GTYHGSPDQS HQVTGNHQQP PQQNTGFPRS
610 620 630 640 650
NQPYYNSRGV SRGGSRGARG LMNGYRGPAN GFRGGYDGYR PSFSNTPNSG
660 670 680 690 700
YTQSQFSAPR DYSGYQRDGY QQNFKRGSGQ SGPRGAPRGR GGPPRPNRGM
PQMNTQQVN
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketG3V153 | G3V153_HUMAN | Caprin-1 | CAPRIN1 GPIAP1, hCG_27570 | 628 | Annotation score: | ||
E9PLA9 | E9PLA9_HUMAN | Caprin-1 | CAPRIN1 | 186 | Annotation score: |
Sequence cautioni
The sequence CAA61751 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAA88096 differs from that shown. Reason: Frameshift.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 370 | Y → D in CAA88096 (PubMed:7657653).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_042425 | 263 | A → D1 PublicationCorresponds to variant dbSNP:rs1132973Ensembl. | 1 | |
Natural variantiVAR_042426 | 588 | Q → H. Corresponds to variant dbSNP:rs12282627Ensembl. | 1 | |
Natural variantiVAR_042427 | 616 | R → H. Corresponds to variant dbSNP:rs11552285Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_032687 | 690 – 709 | RGGPP…TQQVN → NILWW in isoform 2. CuratedAdd BLAST | 20 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z48042 mRNA Translation: CAA88096.1 Frameshift. AC090469 Genomic DNA No translation available. CH471064 Genomic DNA Translation: EAW68177.1 CH471064 Genomic DNA Translation: EAW68178.1 CH471064 Genomic DNA Translation: EAW68179.1 BC001731 mRNA Translation: AAH01731.2 X89572 Genomic DNA Translation: CAA61751.1 Sequence problems. BK001101 mRNA Translation: DAA01118.1 BK001104 mRNA Translation: DAA01121.1 BR000867 mRNA Translation: FAA00692.1 |
CCDSi | CCDS31453.1 [Q14444-1] CCDS31454.1 [Q14444-2] |
PIRi | A57352 |
RefSeqi | NP_005889.3, NM_005898.4 [Q14444-1] NP_976240.1, NM_203364.2 [Q14444-2] XP_016873238.1, XM_017017749.1 |
Genome annotation databases
Ensembli | ENST00000341394; ENSP00000340329; ENSG00000135387 [Q14444-1] ENST00000389645; ENSP00000374296; ENSG00000135387 [Q14444-2] ENST00000530820; ENSP00000434204; ENSG00000135387 [Q14444-2] ENST00000532820; ENSP00000434150; ENSG00000135387 [Q14444-1] |
GeneIDi | 4076 |
KEGGi | hsa:4076 |
UCSCi | uc001mvg.4, human [Q14444-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z48042 mRNA Translation: CAA88096.1 Frameshift. AC090469 Genomic DNA No translation available. CH471064 Genomic DNA Translation: EAW68177.1 CH471064 Genomic DNA Translation: EAW68178.1 CH471064 Genomic DNA Translation: EAW68179.1 BC001731 mRNA Translation: AAH01731.2 X89572 Genomic DNA Translation: CAA61751.1 Sequence problems. BK001101 mRNA Translation: DAA01118.1 BK001104 mRNA Translation: DAA01121.1 BR000867 mRNA Translation: FAA00692.1 |
CCDSi | CCDS31453.1 [Q14444-1] CCDS31454.1 [Q14444-2] |
PIRi | A57352 |
RefSeqi | NP_005889.3, NM_005898.4 [Q14444-1] NP_976240.1, NM_203364.2 [Q14444-2] XP_016873238.1, XM_017017749.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4WBE | X-ray | 2.05 | A/B/C | 132-251 | [»] | |
4WBP | X-ray | 2.50 | A/B | 132-251 | [»] | |
SMRi | Q14444 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 110252, 183 interactors |
CORUMi | Q14444 |
IntActi | Q14444, 52 interactors |
MINTi | Q14444 |
STRINGi | 9606.ENSP00000340329 |
Chemistry databases
ChEMBLi | CHEMBL4295821 |
PTM databases
iPTMneti | Q14444 |
MetOSitei | Q14444 |
PhosphoSitePlusi | Q14444 |
SwissPalmi | Q14444 |
Genetic variation databases
BioMutai | CAPRIN1 |
DMDMi | 182676426 |
Proteomic databases
CPTACi | CPTAC-37 CPTAC-38 |
EPDi | Q14444 |
jPOSTi | Q14444 |
MassIVEi | Q14444 |
MaxQBi | Q14444 |
PaxDbi | Q14444 |
PeptideAtlasi | Q14444 |
PRIDEi | Q14444 |
ProteomicsDBi | 59992 [Q14444-1] 59993 [Q14444-2] |
Protocols and materials databases
Antibodypediai | 12960, 306 antibodies |
DNASUi | 4076 |
Genome annotation databases
Ensembli | ENST00000341394; ENSP00000340329; ENSG00000135387 [Q14444-1] ENST00000389645; ENSP00000374296; ENSG00000135387 [Q14444-2] ENST00000530820; ENSP00000434204; ENSG00000135387 [Q14444-2] ENST00000532820; ENSP00000434150; ENSG00000135387 [Q14444-1] |
GeneIDi | 4076 |
KEGGi | hsa:4076 |
UCSCi | uc001mvg.4, human [Q14444-1] |
Organism-specific databases
CTDi | 4076 |
DisGeNETi | 4076 |
GeneCardsi | CAPRIN1 |
HGNCi | HGNC:6743, CAPRIN1 |
HPAi | ENSG00000135387, Low tissue specificity |
MIMi | 601178, gene |
neXtProti | NX_Q14444 |
OpenTargetsi | ENSG00000135387 |
PharmGKBi | PA30508 |
VEuPathDBi | HostDB:ENSG00000135387.19 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QUGC, Eukaryota |
GeneTreei | ENSGT00940000153438 |
InParanoidi | Q14444 |
OMAi | VEQNYFK |
OrthoDBi | 382856at2759 |
PhylomeDBi | Q14444 |
TreeFami | TF329471 |
Enzyme and pathway databases
PathwayCommonsi | Q14444 |
SIGNORi | Q14444 |
Miscellaneous databases
BioGRID-ORCSi | 4076, 56 hits in 997 CRISPR screens |
ChiTaRSi | CAPRIN1, human |
GeneWikii | CAPRIN1 |
GenomeRNAii | 4076 |
Pharosi | Q14444, Tbio |
PROi | PR:Q14444 |
RNActi | Q14444, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000135387, Expressed in testis and 248 other tissues |
ExpressionAtlasi | Q14444, baseline and differential |
Genevisiblei | Q14444, HS |
Family and domain databases
IDEALi | IID00668 |
InterProi | View protein in InterPro IPR028816, Caprin IPR022070, Caprin-1_C IPR041637, Caprin-1_dimer |
PANTHERi | PTHR22922, PTHR22922, 1 hit |
Pfami | View protein in Pfam PF12287, Caprin-1_C, 1 hit PF18293, Caprin-1_dimer, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CAPR1_HUMAN | |
Accessioni | Q14444Primary (citable) accession number: Q14444 Secondary accession number(s): A6NMY7 Q9BV09 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | April 8, 2008 | |
Last modified: | April 7, 2021 | |
This is version 176 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families