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UniProtKB - Q14444 (CAPR1_HUMAN)

Protein

Caprin-1

Gene

CAPRIN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May regulate the transport and translation of mRNAs of proteins involved in synaptic plasticity in neurons and cell proliferation and migration in multiple cell types. Binds directly and selectively to MYC and CCND2 RNAs. In neuronal cells, directly binds to several mRNAs associated with RNA granules, including BDNF, CAMK2A, CREB1, MAP2, NTRK2 mRNAs, as well as to GRIN1 and KPNB1 mRNAs, but not to rRNAs.1 Publication

Miscellaneous

Overexpression induces the formation of cytoplasmic stress granules and EIF2A phosphorylation through a mechanism that depends on its ability to bind mRNA.

Caution

Was originally thought to be a GPI-anchored membrane protein.1 Publication

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionProtein synthesis inhibitor, RNA-binding
Biological processDifferentiation

Names & Taxonomyi

Protein namesi
Recommended name:
Caprin-1
Alternative name(s):
Cell cycle-associated protein 1
Cytoplasmic activation- and proliferation-associated protein 1
GPI-anchored membrane protein 1
GPI-anchored protein p137
Short name:
GPI-p137
Short name:
p137GPI
Membrane component chromosome 11 surface marker 1
RNA granule protein 105
Gene namesi
Name:CAPRIN1
Synonyms:GPIAP1, GPIP137, M11S1, RNG105
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000135387.19
HGNCiHGNC:6743 CAPRIN1
MIMi601178 gene
neXtProtiNX_Q14444

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi612R → A: Major reduction in MYC and CCND2 RNA-binding; when associated with A-633 and A-690. 1 Publication1
Mutagenesisi633R → A: Major reduction in MYC and CCND2 RNA-binding; when associated with A-612 and A-690. 1 Publication1
Mutagenesisi690R → A: Major reduction in MYC and CCND2 RNA-binding; when associated with A-612 and A-633. 1 Publication1

Organism-specific databases

DisGeNETi4076
OpenTargetsiENSG00000135387
PharmGKBiPA30508

Polymorphism and mutation databases

BioMutaiCAPRIN1
DMDMi182676426

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000875492 – 709Caprin-1Add BLAST708

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylprolineCombined sources1
Modified residuei10PhosphoserineCombined sources1
Modified residuei115PhosphoserineCombined sources1
Modified residuei165Omega-N-methylarginineBy similarity1
Modified residuei335PhosphoserineCombined sources1
Modified residuei343PhosphoserineCombined sources1
Modified residuei626Omega-N-methylarginineCombined sources1
Modified residuei633Omega-N-methylarginineCombined sources1
Modified residuei640Omega-N-methylarginineCombined sources1
Modified residuei698Asymmetric dimethylarginine; alternateCombined sources1
Modified residuei698Omega-N-methylarginine; alternateCombined sources1

Post-translational modificationi

O-glycosylated (O-GlcNAcylated), in a cell cycle-dependent manner.1 Publication

Keywords - PTMi

Acetylation, Glycoprotein, Methylation, Phosphoprotein

Proteomic databases

EPDiQ14444
MaxQBiQ14444
PaxDbiQ14444
PeptideAtlasiQ14444
PRIDEiQ14444
ProteomicsDBi59992
59993 [Q14444-2]

PTM databases

iPTMnetiQ14444
PhosphoSitePlusiQ14444
SwissPalmiQ14444

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiENSG00000135387 Expressed in 236 organ(s), highest expression level in testis
CleanExiHS_CAPRIN1
ExpressionAtlasiQ14444 baseline and differential
GenevisibleiQ14444 HS

Organism-specific databases

HPAiHPA018126
HPA063617

Interactioni

Subunit structurei

May form homomultimers (By similarity). Interacts with G3BP1; interaction is direct and takes place in cytoplasmic RNA granules (PubMed:17210633). Interacts with PQBP1 (PubMed:21933836).By similarity2 Publications

Protein-protein interaction databases

BioGridi110252, 45 interactors
CORUMiQ14444
IntActiQ14444, 26 interactors
MINTiQ14444
STRINGi9606.ENSP00000340329

Structurei

Secondary structure

1709
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ14444
SMRiQ14444
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni360 – 381G3BP1-bindingAdd BLAST22

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili60 – 94Sequence analysisAdd BLAST35
Coiled coili125 – 153Sequence analysisAdd BLAST29

Sequence similaritiesi

Belongs to the caprin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IEA8 Eukaryota
ENOG4110M5Q LUCA
GeneTreeiENSGT00760000119052
HOVERGENiHBG051781
InParanoidiQ14444
KOiK18743
OMAiVEQNYFK
OrthoDBiEOG091G0575
PhylomeDBiQ14444
TreeFamiTF329471

Family and domain databases

InterProiView protein in InterPro
IPR028816 Caprin
IPR022070 Caprin-1_C
PANTHERiPTHR22922 PTHR22922, 1 hit
PfamiView protein in Pfam
PF12287 Caprin-1_C, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q14444-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPSATSHSGS GSKSSGPPPP SGSSGSEAAA GAGAAAPASQ HPATGTGAVQ 
        60         70         80         90        100
TEAMKQILGV IDKKLRNLEK KKGKLDDYQE RMNKGERLNQ DQLDAVSKYQ 
       110        120        130        140        150
EVTNNLEFAK ELQRSFMALS QDIQKTIKKT ARREQLMREE AEQKRLKTVL 
       160        170        180        190        200
ELQYVLDKLG DDEVRTDLKQ GLNGVPILSE EELSLLDEFY KLVDPERDMS 
       210        220        230        240        250
LRLNEQYEHA SIHLWDLLEG KEKPVCGTTY KVLKEIVERV FQSNYFDSTH 
       260        270        280        290        300
NHQNGLCEEE EAASAPAVED QVPEAEPEPA EEYTEQSEVE STEYVNRQFM 
       310        320        330        340        350
AETQFTSGEK EQVDEWTVET VEVVNSLQQQ PQAASPSVPE PHSLTPVAQA 
       360        370        380        390        400
DPLVRRQRVQ DLMAQMQGPY NFIQDSMLDF ENQTLDPAIV SAQPMNPTQN 
       410        420        430        440        450
MDMPQLVCPP VHSESRLAQP NQVPVQPEAT QVPLVSSTSE GYTASQPLYQ 
       460        470        480        490        500
PSHATEQRPQ KEPIDQIQAT ISLNTDQTTA SSSLPAASQP QVFQAGTSKP 
       510        520        530        540        550
LHSSGINVNA APFQSMQTVF NMNAPVPPVN EPETLKQQNQ YQASYNQSFS 
       560        570        580        590        600
SQPHQVEQTE LQQEQLQTVV GTYHGSPDQS HQVTGNHQQP PQQNTGFPRS 
       610        620        630        640        650
NQPYYNSRGV SRGGSRGARG LMNGYRGPAN GFRGGYDGYR PSFSNTPNSG 
       660        670        680        690        700
YTQSQFSAPR DYSGYQRDGY QQNFKRGSGQ SGPRGAPRGR GGPPRPNRGM 

PQMNTQQVN
Length:709
Mass (Da):78,366
Last modified:April 8, 2008 - v2
Checksum:i56F5BC188CA3A2D4
GO
Isoform 2 (identifier: Q14444-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     690-709: RGGPPRPNRGMPQMNTQQVN → NILWW

Note: No experimental confirmation available.
Show »
Length:694
Mass (Da):76,862
Checksum:iA908B217A6B88D5C
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PLA9E9PLA9_HUMAN
Caprin-1
CAPRIN1
186Annotation score:
G3V153G3V153_HUMAN
Caprin-1
CAPRIN1 GPIAP1, hCG_27570
628Annotation score:

Sequence cautioni

The sequence CAA61751 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAA88096 differs from that shown. Reason: Frameshift at positions 11 and 629.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti370Y → D in CAA88096 (PubMed:7657653).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_042425263A → D1 PublicationCorresponds to variant dbSNP:rs1132973Ensembl.1
Natural variantiVAR_042426588Q → H. Corresponds to variant dbSNP:rs12282627Ensembl.1
Natural variantiVAR_042427616R → H. Corresponds to variant dbSNP:rs11552285Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_032687690 – 709RGGPP…TQQVN → NILWW in isoform 2. CuratedAdd BLAST20

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z48042 mRNA Translation: CAA88096.1 Frameshift.
AC090469 Genomic DNA No translation available.
CH471064 Genomic DNA Translation: EAW68177.1
CH471064 Genomic DNA Translation: EAW68178.1
CH471064 Genomic DNA Translation: EAW68179.1
BC001731 mRNA Translation: AAH01731.2
X89572 Genomic DNA Translation: CAA61751.1 Sequence problems.
BK001101 mRNA Translation: DAA01118.1
BK001104 mRNA Translation: DAA01121.1
BR000867 mRNA Translation: FAA00692.1
CCDSiCCDS31453.1 [Q14444-1]
CCDS31454.1 [Q14444-2]
PIRiA57352
RefSeqiNP_005889.3, NM_005898.4 [Q14444-1]
NP_976240.1, NM_203364.2 [Q14444-2]
XP_016873238.1, XM_017017749.1
UniGeneiHs.471818

Genome annotation databases

EnsembliENST00000341394; ENSP00000340329; ENSG00000135387 [Q14444-1]
ENST00000389645; ENSP00000374296; ENSG00000135387 [Q14444-2]
ENST00000530820; ENSP00000434204; ENSG00000135387 [Q14444-2]
ENST00000532820; ENSP00000434150; ENSG00000135387 [Q14444-1]
GeneIDi4076
KEGGihsa:4076
UCSCiuc001mvg.4 human [Q14444-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z48042 mRNA Translation: CAA88096.1 Frameshift.
AC090469 Genomic DNA No translation available.
CH471064 Genomic DNA Translation: EAW68177.1
CH471064 Genomic DNA Translation: EAW68178.1
CH471064 Genomic DNA Translation: EAW68179.1
BC001731 mRNA Translation: AAH01731.2
X89572 Genomic DNA Translation: CAA61751.1 Sequence problems.
BK001101 mRNA Translation: DAA01118.1
BK001104 mRNA Translation: DAA01121.1
BR000867 mRNA Translation: FAA00692.1
CCDSiCCDS31453.1 [Q14444-1]
CCDS31454.1 [Q14444-2]
PIRiA57352
RefSeqiNP_005889.3, NM_005898.4 [Q14444-1]
NP_976240.1, NM_203364.2 [Q14444-2]
XP_016873238.1, XM_017017749.1
UniGeneiHs.471818

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4WBEX-ray2.05A/B/C132-251[»]
4WBPX-ray2.50A/B132-251[»]
ProteinModelPortaliQ14444
SMRiQ14444
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110252, 45 interactors
CORUMiQ14444
IntActiQ14444, 26 interactors
MINTiQ14444
STRINGi9606.ENSP00000340329

PTM databases

iPTMnetiQ14444
PhosphoSitePlusiQ14444
SwissPalmiQ14444

Polymorphism and mutation databases

BioMutaiCAPRIN1
DMDMi182676426

Proteomic databases

EPDiQ14444
MaxQBiQ14444
PaxDbiQ14444
PeptideAtlasiQ14444
PRIDEiQ14444
ProteomicsDBi59992
59993 [Q14444-2]

Protocols and materials databases

DNASUi4076
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000341394; ENSP00000340329; ENSG00000135387 [Q14444-1]
ENST00000389645; ENSP00000374296; ENSG00000135387 [Q14444-2]
ENST00000530820; ENSP00000434204; ENSG00000135387 [Q14444-2]
ENST00000532820; ENSP00000434150; ENSG00000135387 [Q14444-1]
GeneIDi4076
KEGGihsa:4076
UCSCiuc001mvg.4 human [Q14444-1]

Organism-specific databases

CTDi4076
DisGeNETi4076
EuPathDBiHostDB:ENSG00000135387.19
GeneCardsiCAPRIN1
H-InvDBiHIX0009545
HGNCiHGNC:6743 CAPRIN1
HPAiHPA018126
HPA063617
MIMi601178 gene
neXtProtiNX_Q14444
OpenTargetsiENSG00000135387
PharmGKBiPA30508
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEA8 Eukaryota
ENOG4110M5Q LUCA
GeneTreeiENSGT00760000119052
HOVERGENiHBG051781
InParanoidiQ14444
KOiK18743
OMAiVEQNYFK
OrthoDBiEOG091G0575
PhylomeDBiQ14444
TreeFamiTF329471

Miscellaneous databases

ChiTaRSiCAPRIN1 human
GeneWikiiCAPRIN1
GenomeRNAii4076
PROiPR:Q14444
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000135387 Expressed in 236 organ(s), highest expression level in testis
CleanExiHS_CAPRIN1
ExpressionAtlasiQ14444 baseline and differential
GenevisibleiQ14444 HS

Family and domain databases

InterProiView protein in InterPro
IPR028816 Caprin
IPR022070 Caprin-1_C
PANTHERiPTHR22922 PTHR22922, 1 hit
PfamiView protein in Pfam
PF12287 Caprin-1_C, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCAPR1_HUMAN
AccessioniPrimary (citable) accession number: Q14444
Secondary accession number(s): A6NMY7
, D3DR06, Q15074, Q6IMN4, Q6IMN7, Q9BV09
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: April 8, 2008
Last modified: November 7, 2018
This is version 157 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
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