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Protein

cGMP-inhibited 3',5'-cyclic phosphodiesterase A

Gene

PDE3A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

a divalent metal cationBy similarityNote: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.By similarity

<p>This subsection of the ‘Function’ section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by cGMP.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei752Proton donorBy similarity1
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi756Divalent metal cation 1By similarity1
Metal bindingi836Divalent metal cation 1By similarity1
Metal bindingi837Divalent metal cation 1By similarity1
Metal bindingi837Divalent metal cation 2By similarity1
Metal bindingi950Divalent metal cation 1By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • 3',5'-cyclic-AMP phosphodiesterase activity Source: GO_Central
  • 3',5'-cyclic-GMP phosphodiesterase activity Source: Reactome
  • cGMP-inhibited cyclic-nucleotide phosphodiesterase activity Source: ProtInc
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase
LigandcAMP, cGMP, Metal-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
3.1.4.17 2681

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-418457 cGMP effects
R-HSA-418555 G alpha (s) signalling events

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
Q14432

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q14432

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
cGMP-inhibited 3',5'-cyclic phosphodiesterase A (EC:3.1.4.17)
Alternative name(s):
Cyclic GMP-inhibited phosphodiesterase A
Short name:
CGI-PDE A
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PDE3A
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000172572.6

Human Gene Nomenclature Database

More...
HGNCi
HGNC:8778 PDE3A

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
123805 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q14432

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei61 – 81HelicalSequence analysisAdd BLAST21
Transmembranei130 – 150HelicalSequence analysisAdd BLAST21
Transmembranei160 – 180HelicalSequence analysisAdd BLAST21
Transmembranei185 – 205HelicalSequence analysisAdd BLAST21
Transmembranei210 – 230HelicalSequence analysisAdd BLAST21
Transmembranei232 – 252HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Hypertension and brachydactyly syndrome (HTNB)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA syndrome characterized by brachydactyly type E, severe salt-independent but age-dependent hypertension, an increased fibroblast growth rate, neurovascular contact at the rostral-ventrolateral medulla, and altered baroreflex blood pressure regulation. It results in death from stroke before age 50 years when untreated. Brachydactyly type E is characterized by shortening of the fingers mainly in the metacarpals and metatarsals.
See also OMIM:112410
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_073869445T → A in HTNB; gain of function mutation with increased cAMP-hydrolytic activity. 1 PublicationCorresponds to variant dbSNP:rs794726865EnsemblClinVar.1
Natural variantiVAR_073870445T → N in HTNB; gain of function mutation with increased cAMP-hydrolytic activity. 1 PublicationCorresponds to variant dbSNP:rs794726864EnsemblClinVar.1
Natural variantiVAR_073871445T → S in HTNB; gain of function mutation with increased cAMP-hydrolytic activity. 1 PublicationCorresponds to variant dbSNP:rs794726864EnsemblClinVar.1
Natural variantiVAR_073872447A → T in HTNB; gain of function mutation with increased cAMP-hydrolytic activity. 1 PublicationCorresponds to variant dbSNP:rs794726866EnsemblClinVar.1
Natural variantiVAR_073873447A → V in HTNB; gain of function mutationwith increased cAMP-hydrolytic activity. 1 PublicationCorresponds to variant dbSNP:rs794726867EnsemblClinVar.1
Natural variantiVAR_073874449G → V in HTNB; gain of function mutation with increased cAMP-hydrolytic activity. 1 PublicationCorresponds to variant dbSNP:rs794726868EnsemblClinVar.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
5139

MalaCards human disease database

More...
MalaCardsi
PDE3A
MIMi112410 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000172572

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
1276 Brachydactyly-arterial hypertension syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA33126

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

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ChEMBLi
CHEMBL241

Drug and drug target database

More...
DrugBanki
DB01223 Aminophylline
DB01427 Amrinone
DB00261 Anagrelide
DB00201 Caffeine
DB01166 Cilostazol
DB04880 Enoximone
DB05266 Ibudilast
DB00922 Levosimendan
DB00235 Milrinone
DB01303 Oxtriphylline
DB00277 Theophylline
DB08811 Tofisopam

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
1298

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PDE3A

Domain mapping of disease mutations (DMDM)

More...
DMDMi
47117888

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001987991 – 1141cGMP-inhibited 3',5'-cyclic phosphodiesterase AAdd BLAST1141

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei312PhosphoserineCombined sources1
Modified residuei492PhosphoserineCombined sources1
Modified residuei520PhosphoserineCombined sources1
Modified residuei524PhosphoserineBy similarity1
Modified residuei1033PhosphoserineBy similarity1
Modified residuei1036PhosphothreonineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki1120Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q14432

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q14432

MaxQB - The MaxQuant DataBase

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MaxQBi
Q14432

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q14432

PeptideAtlas

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PeptideAtlasi
Q14432

PRoteomics IDEntifications database

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PRIDEi
Q14432

ProteomicsDB human proteome resource

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ProteomicsDBi
59987

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q14432

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q14432

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000172572 Expressed in 170 organ(s), highest expression level in heart right ventricle

CleanEx database of gene expression profiles

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CleanExi
HS_PDE3A

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q14432 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA014492

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
111165, 28 interactors

Database of interacting proteins

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DIPi
DIP-42197N

Protein interaction database and analysis system

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IntActi
Q14432, 18 interactors

Molecular INTeraction database

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MINTi
Q14432

STRING: functional protein association networks

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STRINGi
9606.ENSP00000351957

Chemistry databases

BindingDB database of measured binding affinities

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BindingDBi
Q14432

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1LRCmodel-A812-1017[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q14432

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q14432

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini674 – 1093PDEasePROSITE-ProRule annotationAdd BLAST420

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi95 – 98Poly-Ala4
Compositional biasi99 – 102Poly-Glu4
Compositional biasi288 – 291Poly-Arg4
Compositional biasi440 – 445Poly-Thr6
Compositional biasi870 – 873Poly-Ala4
Compositional biasi1040 – 1045Poly-Glu6
Compositional biasi1121 – 1125Poly-Glu5

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IEGG Eukaryota
ENOG410XT2V LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000156628

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000060144

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG053541

KEGG Orthology (KO)

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KOi
K19021

Identification of Orthologs from Complete Genome Data

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OMAi
PNEEETC

Database of Orthologous Groups

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OrthoDBi
1051097at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q14432

TreeFam database of animal gene trees

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TreeFami
TF329631

Family and domain databases

Conserved Domains Database

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CDDi
cd00077 HDc, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.10.1300.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR003607 HD/PDEase_dom
IPR002073 PDEase_catalytic_dom
IPR036971 PDEase_catalytic_dom_sf
IPR023174 PDEase_CS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00233 PDEase_I, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00471 HDc, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00126 PDEASE_I_1, 1 hit
PS51845 PDEASE_I_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q14432-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAVPGDAARV RDKPVHSGVS QAPTAGRDCH HRADPASPRD SGCRGCWGDL
60 70 80 90 100
VLQPLRSSRK LSSALCAGSL SFLLALLVRL VRGEVGCDLE QCKEAAAAEE
110 120 130 140 150
EEAAPGAEGG VFPGPRGGAP GGGARLSPWL QPSALLFSLL CAFFWMGLYL
160 170 180 190 200
LRAGVRLPLA VALLAACCGG EALVQIGLGV GEDHLLSLPA AGVVLSCLAA
210 220 230 240 250
ATWLVLRLRL GVLMIALTSA VRTVSLISLE RFKVAWRPYL AYLAGVLGIL
260 270 280 290 300
LARYVEQILP QSAEAAPREH LGSQLIAGTK EDIPVFKRRR RSSSVVSAEM
310 320 330 340 350
SGCSSKSHRR TSLPCIPREQ LMGHSEWDHK RGPRGSQSSG TSITVDIAVM
360 370 380 390 400
GEAHGLITDL LADPSLPPNV CTSLRAVSNL LSTQLTFQAI HKPRVNPVTS
410 420 430 440 450
LSENYTCSDS EESSEKDKLA IPKRLRRSLP PGLLRRVSST WTTTTSATGL
460 470 480 490 500
PTLEPAPVRR DRSTSIKLQE APSSSPDSWN NPVMMTLTKS RSFTSSYAIS
510 520 530 540 550
AANHVKAKKQ SRPGALAKIS PLSSPCSSPL QGTPASSLVS KISAVQFPES
560 570 580 590 600
ADTTAKQSLG SHRALTYTQS APDLSPQILT PPVICSSCGR PYSQGNPADE
610 620 630 640 650
PLERSGVATR TPSRTDDTAQ VTSDYETNNN SDSSDIVQNE DETECLREPL
660 670 680 690 700
RKASACSTYA PETMMFLDKP ILAPEPLVMD NLDSIMEQLN TWNFPIFDLV
710 720 730 740 750
ENIGRKCGRI LSQVSYRLFE DMGLFEAFKI PIREFMNYFH ALEIGYRDIP
760 770 780 790 800
YHNRIHATDV LHAVWYLTTQ PIPGLSTVIN DHGSTSDSDS DSGFTHGHMG
810 820 830 840 850
YVFSKTYNVT DDKYGCLSGN IPALELMALY VAAAMHDYDH PGRTNAFLVA
860 870 880 890 900
TSAPQAVLYN DRSVLENHHA AAAWNLFMSR PEYNFLINLD HVEFKHFRFL
910 920 930 940 950
VIEAILATDL KKHFDFVAKF NGKVNDDVGI DWTNENDRLL VCQMCIKLAD
960 970 980 990 1000
INGPAKCKEL HLQWTDGIVN EFYEQGDEEA SLGLPISPFM DRSAPQLANL
1010 1020 1030 1040 1050
QESFISHIVG PLCNSYDSAG LMPGKWVEDS DESGDTDDPE EEEEEAPAPN
1060 1070 1080 1090 1100
EEETCENNES PKKKTFKRRK IYCQITQHLL QNHKMWKKVI EEEQRLAGIE
1110 1120 1130 1140
NQSLDQTPQS HSSEQIQAIK EEEEEKGKPR GEEIPTQKPD Q
Length:1,141
Mass (Da):124,979
Last modified:May 10, 2004 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE69504130F39EFEA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti69S → C in AAB18673 (PubMed:8695850).Curated1
Sequence conflicti110G → A in AAB18673 (PubMed:8695850).Curated1
Sequence conflicti354 – 371HGLIT…PPNVC → TASLPTSWQTLLFHQTCA (PubMed:8695850).CuratedAdd BLAST18
Sequence conflicti354 – 371HGLIT…PPNVC → TASLPTSWQTLLFHQTCA in CAA06304 (PubMed:10421499).CuratedAdd BLAST18

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05954312D → N1 PublicationCorresponds to variant dbSNP:rs12305038Ensembl.1
Natural variantiVAR_073869445T → A in HTNB; gain of function mutation with increased cAMP-hydrolytic activity. 1 PublicationCorresponds to variant dbSNP:rs794726865EnsemblClinVar.1
Natural variantiVAR_073870445T → N in HTNB; gain of function mutation with increased cAMP-hydrolytic activity. 1 PublicationCorresponds to variant dbSNP:rs794726864EnsemblClinVar.1
Natural variantiVAR_073871445T → S in HTNB; gain of function mutation with increased cAMP-hydrolytic activity. 1 PublicationCorresponds to variant dbSNP:rs794726864EnsemblClinVar.1
Natural variantiVAR_073872447A → T in HTNB; gain of function mutation with increased cAMP-hydrolytic activity. 1 PublicationCorresponds to variant dbSNP:rs794726866EnsemblClinVar.1
Natural variantiVAR_073873447A → V in HTNB; gain of function mutationwith increased cAMP-hydrolytic activity. 1 PublicationCorresponds to variant dbSNP:rs794726867EnsemblClinVar.1
Natural variantiVAR_073874449G → V in HTNB; gain of function mutation with increased cAMP-hydrolytic activity. 1 PublicationCorresponds to variant dbSNP:rs794726868EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
M91667 mRNA Translation: AAA35912.2
U36798 mRNA Translation: AAB18673.1
AJ005036 mRNA Translation: CAA06304.1
BC117369 mRNA Translation: AAI17370.1
BC117371 mRNA Translation: AAI17372.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS31754.1

Protein sequence database of the Protein Information Resource

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PIRi
A44093

NCBI Reference Sequences

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RefSeqi
NP_000912.3, NM_000921.4

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.386791
Hs.737522

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000359062; ENSP00000351957; ENSG00000172572

Database of genes from NCBI RefSeq genomes

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GeneIDi
5139

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:5139

UCSC genome browser

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UCSCi
uc001reh.3 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Wikipedia

PDE3 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M91667 mRNA Translation: AAA35912.2
U36798 mRNA Translation: AAB18673.1
AJ005036 mRNA Translation: CAA06304.1
BC117369 mRNA Translation: AAI17370.1
BC117371 mRNA Translation: AAI17372.1
CCDSiCCDS31754.1
PIRiA44093
RefSeqiNP_000912.3, NM_000921.4
UniGeneiHs.386791
Hs.737522

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1LRCmodel-A812-1017[»]
ProteinModelPortaliQ14432
SMRiQ14432
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111165, 28 interactors
DIPiDIP-42197N
IntActiQ14432, 18 interactors
MINTiQ14432
STRINGi9606.ENSP00000351957

Chemistry databases

BindingDBiQ14432
ChEMBLiCHEMBL241
DrugBankiDB01223 Aminophylline
DB01427 Amrinone
DB00261 Anagrelide
DB00201 Caffeine
DB01166 Cilostazol
DB04880 Enoximone
DB05266 Ibudilast
DB00922 Levosimendan
DB00235 Milrinone
DB01303 Oxtriphylline
DB00277 Theophylline
DB08811 Tofisopam
GuidetoPHARMACOLOGYi1298

PTM databases

iPTMnetiQ14432
PhosphoSitePlusiQ14432

Polymorphism and mutation databases

BioMutaiPDE3A
DMDMi47117888

Proteomic databases

EPDiQ14432
jPOSTiQ14432
MaxQBiQ14432
PaxDbiQ14432
PeptideAtlasiQ14432
PRIDEiQ14432
ProteomicsDBi59987

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000359062; ENSP00000351957; ENSG00000172572
GeneIDi5139
KEGGihsa:5139
UCSCiuc001reh.3 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
5139
DisGeNETi5139
EuPathDBiHostDB:ENSG00000172572.6

GeneCards: human genes, protein and diseases

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GeneCardsi
PDE3A
HGNCiHGNC:8778 PDE3A
HPAiHPA014492
MalaCardsiPDE3A
MIMi112410 phenotype
123805 gene
neXtProtiNX_Q14432
OpenTargetsiENSG00000172572
Orphaneti1276 Brachydactyly-arterial hypertension syndrome
PharmGKBiPA33126

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IEGG Eukaryota
ENOG410XT2V LUCA
GeneTreeiENSGT00940000156628
HOGENOMiHOG000060144
HOVERGENiHBG053541
KOiK19021
OMAiPNEEETC
OrthoDBi1051097at2759
PhylomeDBiQ14432
TreeFamiTF329631

Enzyme and pathway databases

BRENDAi3.1.4.17 2681
ReactomeiR-HSA-418457 cGMP effects
R-HSA-418555 G alpha (s) signalling events
SABIO-RKiQ14432
SIGNORiQ14432

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
PDE3A human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
5139

Protein Ontology

More...
PROi
PR:Q14432

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000172572 Expressed in 170 organ(s), highest expression level in heart right ventricle
CleanExiHS_PDE3A
GenevisibleiQ14432 HS

Family and domain databases

CDDicd00077 HDc, 1 hit
Gene3Di1.10.1300.10, 1 hit
InterProiView protein in InterPro
IPR003607 HD/PDEase_dom
IPR002073 PDEase_catalytic_dom
IPR036971 PDEase_catalytic_dom_sf
IPR023174 PDEase_CS
PfamiView protein in Pfam
PF00233 PDEase_I, 1 hit
SMARTiView protein in SMART
SM00471 HDc, 1 hit
PROSITEiView protein in PROSITE
PS00126 PDEASE_I_1, 1 hit
PS51845 PDEASE_I_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPDE3A_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q14432
Secondary accession number(s): O60865, Q13348, Q17RD1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 10, 2004
Last modified: January 16, 2019
This is version 174 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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