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Protein

Metabotropic glutamate receptor 2

Gene

GRM2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. May mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization.4 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei145GlutamateBy similarity1
Binding sitei216GlutamateBy similarity1
Binding sitei295GlutamateBy similarity1
Binding sitei377GlutamateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-HSA-418594 G alpha (i) signalling events
R-HSA-420499 Class C/3 (Metabotropic glutamate/pheromone receptors)
SIGNORiQ14416

Names & Taxonomyi

Protein namesi
Recommended name:
Metabotropic glutamate receptor 2
Short name:
mGluR2
Gene namesi
Name:GRM2
Synonyms:GPRC1B, MGLUR2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000164082.14
HGNCiHGNC:4594 GRM2
MIMi604099 gene
neXtProtiNX_Q14416

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini19 – 567ExtracellularSequence analysisAdd BLAST549
Transmembranei568 – 590Helical; Name=1Sequence analysisAdd BLAST23
Topological domaini591 – 604CytoplasmicSequence analysisAdd BLAST14
Transmembranei605 – 625Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini626 – 636ExtracellularSequence analysisAdd BLAST11
Transmembranei637 – 655Helical; Name=3Sequence analysisAdd BLAST19
Topological domaini656 – 679CytoplasmicSequence analysisAdd BLAST24
Transmembranei680 – 700Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini701 – 725ExtracellularSequence analysisAdd BLAST25
Transmembranei726 – 747Helical; Name=5Sequence analysisAdd BLAST22
Topological domaini748 – 760CytoplasmicSequence analysisAdd BLAST13
Transmembranei761 – 783Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini784 – 793ExtracellularSequence analysis10
Transmembranei794 – 819Helical; Name=7Sequence analysisAdd BLAST26
Topological domaini820 – 872CytoplasmicSequence analysisAdd BLAST53

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Membrane, Synapse

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi677A → S: Impairs interaction with HTR2A. 1 Publication1
Mutagenesisi681A → F: Impairs interaction with HTR2A. 1 Publication1
Mutagenesisi685A → G: Impairs interaction with HTR2A. 1 Publication1

Organism-specific databases

DisGeNETi2912
OpenTargetsiENSG00000164082
PharmGKBiPA28991

Chemistry databases

ChEMBLiCHEMBL5137
DrugBankiDB05096 LY2140023
GuidetoPHARMACOLOGYi290

Polymorphism and mutation databases

BioMutaiGRM2
DMDMi76803802

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000001292519 – 872Metabotropic glutamate receptor 2Add BLAST854

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi50 ↔ 92By similarity
Glycosylationi203N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi234 ↔ 518By similarity
Glycosylationi286N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi338N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi355 ↔ 362By similarity
Disulfide bondi400 ↔ 407By similarity
Glycosylationi402N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi500 ↔ 519By similarity
Disulfide bondi504 ↔ 522By similarity
Disulfide bondi525 ↔ 537By similarity
Disulfide bondi540 ↔ 553By similarity
Glycosylationi547N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ14416
PeptideAtlasiQ14416
PRIDEiQ14416
ProteomicsDBi59986

PTM databases

iPTMnetiQ14416
PhosphoSitePlusiQ14416

Expressioni

Tissue specificityi

Detected in brain cortex (at protein level). Widely expressed in different regions of the adult brain as well as in fetal brain.1 Publication

Gene expression databases

BgeeiENSG00000164082 Expressed in 156 organ(s), highest expression level in right testis
CleanExiHS_GRM2
ExpressionAtlasiQ14416 baseline and differential
GenevisibleiQ14416 HS

Organism-specific databases

HPAiHPA027868
HPA065166

Interactioni

Subunit structurei

Interacts with GRASP (By similarity). Interacts with HTR2A.By similarity3 Publications

Binary interactionsi

Protein-protein interaction databases

BioGridi109169, 5 interactors
CORUMiQ14416
DIPiDIP-59826N
IntActiQ14416, 20 interactors
STRINGi9606.ENSP00000378492

Chemistry databases

BindingDBiQ14416

Structurei

Secondary structure

1872
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ14416
SMRiQ14416
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni166 – 168Glutamate bindingBy similarity3
Regioni677 – 685Important for interaction with HTR2A9

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1056 Eukaryota
ENOG410XR6W LUCA
GeneTreeiENSGT00760000118884
HOGENOMiHOG000218635
HOVERGENiHBG107965
InParanoidiQ14416
KOiK04605
OMAiHICPDGS
OrthoDBiEOG091G177R
PhylomeDBiQ14416
TreeFamiTF313240

Family and domain databases

Gene3Di2.10.50.30, 1 hit
InterProiView protein in InterPro
IPR001828 ANF_lig-bd_rcpt
IPR000337 GPCR_3
IPR011500 GPCR_3_9-Cys_dom
IPR038550 GPCR_3_9-Cys_sf
IPR017978 GPCR_3_C
IPR017979 GPCR_3_CS
IPR000162 GPCR_3_mtglu_rcpt
IPR001458 GPCR_3_mtglu_rcpt_2
IPR028082 Peripla_BP_I
PfamiView protein in Pfam
PF00003 7tm_3, 1 hit
PF01094 ANF_receptor, 1 hit
PF07562 NCD3G, 1 hit
PRINTSiPR00248 GPCRMGR
PR01052 MTABOTROPC2R
PR00593 MTABOTROPICR
SUPFAMiSSF53822 SSF53822, 1 hit
PROSITEiView protein in PROSITE
PS00979 G_PROTEIN_RECEP_F3_1, 1 hit
PS00980 G_PROTEIN_RECEP_F3_2, 1 hit
PS00981 G_PROTEIN_RECEP_F3_3, 1 hit
PS50259 G_PROTEIN_RECEP_F3_4, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q14416-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGSLLALLAL LLLWGAVAEG PAKKVLTLEG DLVLGGLFPV HQKGGPAEDC
60 70 80 90 100
GPVNEHRGIQ RLEAMLFALD RINRDPHLLP GVRLGAHILD SCSKDTHALE
110 120 130 140 150
QALDFVRASL SRGADGSRHI CPDGSYATHG DAPTAITGVI GGSYSDVSIQ
160 170 180 190 200
VANLLRLFQI PQISYASTSA KLSDKSRYDY FARTVPPDFF QAKAMAEILR
210 220 230 240 250
FFNWTYVSTV ASEGDYGETG IEAFELEARA RNICVATSEK VGRAMSRAAF
260 270 280 290 300
EGVVRALLQK PSARVAVLFT RSEDARELLA ASQRLNASFT WVASDGWGAL
310 320 330 340 350
ESVVAGSEGA AEGAITIELA SYPISDFASY FQSLDPWNNS RNPWFREFWE
360 370 380 390 400
QRFRCSFRQR DCAAHSLRAV PFEQESKIMF VVNAVYAMAH ALHNMHRALC
410 420 430 440 450
PNTTRLCDAM RPVNGRRLYK DFVLNVKFDA PFRPADTHNE VRFDRFGDGI
460 470 480 490 500
GRYNIFTYLR AGSGRYRYQK VGYWAEGLTL DTSLIPWASP SAGPLPASRC
510 520 530 540 550
SEPCLQNEVK SVQPGEVCCW LCIPCQPYEY RLDEFTCADC GLGYWPNASL
560 570 580 590 600
TGCFELPQEY IRWGDAWAVG PVTIACLGAL ATLFVLGVFV RHNATPVVKA
610 620 630 640 650
SGRELCYILL GGVFLCYCMT FIFIAKPSTA VCTLRRLGLG TAFSVCYSAL
660 670 680 690 700
LTKTNRIARI FGGAREGAQR PRFISPASQV AICLALISGQ LLIVVAWLVV
710 720 730 740 750
EAPGTGKETA PERREVVTLR CNHRDASMLG SLAYNVLLIA LCTLYAFKTR
760 770 780 790 800
KCPENFNEAK FIGFTMYTTC IIWLAFLPIF YVTSSDYRVQ TTTMCVSVSL
810 820 830 840 850
SGSVVLGCLF APKLHIILFQ PQKNVVSHRA PTSRFGSAAA RASSSLGQGS
860 870
GSQFVPTVCN GREVVDSTTS SL
Length:872
Mass (Da):95,568
Last modified:September 27, 2005 - v2
Checksum:i801976D034AA8100
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JL63C9JL63_HUMAN
Metabotropic glutamate receptor 2
GRM2
594Annotation score:
H7BXL3H7BXL3_HUMAN
Metabotropic glutamate receptor 2
GRM2
435Annotation score:
C9JD41C9JD41_HUMAN
Metabotropic glutamate receptor 2
GRM2
70Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti12L → P in AAA76855 (PubMed:7620613).Curated1
Sequence conflicti210V → E in AAA76855 (PubMed:7620613).Curated1
Sequence conflicti496P → A in AAA76855 (PubMed:7620613).Curated1
Sequence conflicti748K → N in AAA76855 (PubMed:7620613).Curated1
Sequence conflicti776F → L in AAA76855 (PubMed:7620613).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L35318 mRNA Translation: AAA76855.1
AB045011 Genomic DNA Translation: BAB19817.1
AY999299 mRNA Translation: AAY14640.1
EU432122 mRNA Translation: ABY87921.1
CH471055 Genomic DNA Translation: EAW65150.1
BC113615 mRNA Translation: AAI13616.1
BC113619 mRNA Translation: AAI13620.1
CCDSiCCDS2834.1
RefSeqiNP_000830.2, NM_000839.3
XP_016861760.1, XM_017006271.1
UniGeneiHs.121510

Genome annotation databases

EnsembliENST00000395052; ENSP00000378492; ENSG00000164082
GeneIDi2912
KEGGihsa:2912
UCSCiuc010hlv.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L35318 mRNA Translation: AAA76855.1
AB045011 Genomic DNA Translation: BAB19817.1
AY999299 mRNA Translation: AAY14640.1
EU432122 mRNA Translation: ABY87921.1
CH471055 Genomic DNA Translation: EAW65150.1
BC113615 mRNA Translation: AAI13616.1
BC113619 mRNA Translation: AAI13620.1
CCDSiCCDS2834.1
RefSeqiNP_000830.2, NM_000839.3
XP_016861760.1, XM_017006271.1
UniGeneiHs.121510

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4XAQX-ray2.21A/B2-493[»]
4XASX-ray2.35A/B2-493[»]
5CNIX-ray2.69A/B2-493[»]
5CNJX-ray2.65A/B2-493[»]
5KZNX-ray2.80A1-562[»]
5KZQX-ray2.80A1-562[»]
ProteinModelPortaliQ14416
SMRiQ14416
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109169, 5 interactors
CORUMiQ14416
DIPiDIP-59826N
IntActiQ14416, 20 interactors
STRINGi9606.ENSP00000378492

Chemistry databases

BindingDBiQ14416
ChEMBLiCHEMBL5137
DrugBankiDB05096 LY2140023
GuidetoPHARMACOLOGYi290

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ14416
PhosphoSitePlusiQ14416

Polymorphism and mutation databases

BioMutaiGRM2
DMDMi76803802

Proteomic databases

PaxDbiQ14416
PeptideAtlasiQ14416
PRIDEiQ14416
ProteomicsDBi59986

Protocols and materials databases

DNASUi2912
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000395052; ENSP00000378492; ENSG00000164082
GeneIDi2912
KEGGihsa:2912
UCSCiuc010hlv.4 human

Organism-specific databases

CTDi2912
DisGeNETi2912
EuPathDBiHostDB:ENSG00000164082.14
GeneCardsiGRM2
HGNCiHGNC:4594 GRM2
HPAiHPA027868
HPA065166
MIMi604099 gene
neXtProtiNX_Q14416
OpenTargetsiENSG00000164082
PharmGKBiPA28991
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1056 Eukaryota
ENOG410XR6W LUCA
GeneTreeiENSGT00760000118884
HOGENOMiHOG000218635
HOVERGENiHBG107965
InParanoidiQ14416
KOiK04605
OMAiHICPDGS
OrthoDBiEOG091G177R
PhylomeDBiQ14416
TreeFamiTF313240

Enzyme and pathway databases

ReactomeiR-HSA-418594 G alpha (i) signalling events
R-HSA-420499 Class C/3 (Metabotropic glutamate/pheromone receptors)
SIGNORiQ14416

Miscellaneous databases

GeneWikiiMetabotropic_glutamate_receptor_2
GenomeRNAii2912
PROiPR:Q14416
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000164082 Expressed in 156 organ(s), highest expression level in right testis
CleanExiHS_GRM2
ExpressionAtlasiQ14416 baseline and differential
GenevisibleiQ14416 HS

Family and domain databases

Gene3Di2.10.50.30, 1 hit
InterProiView protein in InterPro
IPR001828 ANF_lig-bd_rcpt
IPR000337 GPCR_3
IPR011500 GPCR_3_9-Cys_dom
IPR038550 GPCR_3_9-Cys_sf
IPR017978 GPCR_3_C
IPR017979 GPCR_3_CS
IPR000162 GPCR_3_mtglu_rcpt
IPR001458 GPCR_3_mtglu_rcpt_2
IPR028082 Peripla_BP_I
PfamiView protein in Pfam
PF00003 7tm_3, 1 hit
PF01094 ANF_receptor, 1 hit
PF07562 NCD3G, 1 hit
PRINTSiPR00248 GPCRMGR
PR01052 MTABOTROPC2R
PR00593 MTABOTROPICR
SUPFAMiSSF53822 SSF53822, 1 hit
PROSITEiView protein in PROSITE
PS00979 G_PROTEIN_RECEP_F3_1, 1 hit
PS00980 G_PROTEIN_RECEP_F3_2, 1 hit
PS00981 G_PROTEIN_RECEP_F3_3, 1 hit
PS50259 G_PROTEIN_RECEP_F3_4, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGRM2_HUMAN
AccessioniPrimary (citable) accession number: Q14416
Secondary accession number(s): B0M0K7
, Q14CU5, Q52MC6, Q9H3N6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: September 27, 2005
Last modified: October 10, 2018
This is version 148 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  3. SIMILARITY comments
    Index of protein domains and families
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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