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Protein

Glycerol kinase 2

Gene

GK2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Key enzyme in the regulation of glycerol uptake and metabolism.By similarity

Catalytic activityi

ATP + glycerol = ADP + sn-glycerol 3-phosphate.

Pathwayi: glycerol degradation via glycerol kinase pathway

This protein is involved in step 1 of the subpathway that synthesizes sn-glycerol 3-phosphate from glycerol.
Proteins known to be involved in this subpathway in this organism are:
  1. Glycerol kinase 2 (GK2), Glycerol kinase 3 (GK3P), Glycerol kinase (GK), Putative glycerol kinase 5 (GK5)
This subpathway is part of the pathway glycerol degradation via glycerol kinase pathway, which is itself part of Polyol metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes sn-glycerol 3-phosphate from glycerol, the pathway glycerol degradation via glycerol kinase pathway and in Polyol metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei20SubstrateBy similarity1
Binding sitei24ATPBy similarity1
Binding sitei94SubstrateBy similarity1
Binding sitei148SubstrateBy similarity1
Binding sitei259SubstrateBy similarity1
Binding sitei281ATPBy similarity1
Binding sitei326ATP; via carbonyl oxygenBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi427 – 431ATPBy similarity5

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processGlycerol metabolism
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-75109 Triglyceride biosynthesis
UniPathwayi
UPA00618;UER00672

Names & Taxonomyi

Protein namesi
Recommended name:
Glycerol kinase 2 (EC:2.7.1.30)
Short name:
GK 2
Short name:
Glycerokinase 2
Alternative name(s):
ATP:glycerol 3-phosphotransferase 2
Glycerol kinase, testis specific 2
Gene namesi
Name:GK2
Synonyms:GKP2, GKTA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000196475.5
HGNCiHGNC:4291 GK2
MIMi600148 gene
neXtProtiNX_Q14410

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane, Mitochondrion, Mitochondrion outer membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000196475
PharmGKBiPA28702

Polymorphism and mutation databases

BioMutaiGK2
DMDMi212286188

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000595361 – 553Glycerol kinase 2Add BLAST553

Proteomic databases

EPDiQ14410
MaxQBiQ14410
PaxDbiQ14410
PeptideAtlasiQ14410
PRIDEiQ14410
ProteomicsDBi59985

PTM databases

iPTMnetiQ14410
PhosphoSitePlusiQ14410

Expressioni

Gene expression databases

BgeeiENSG00000196475 Expressed in 21 organ(s), highest expression level in testis
ExpressionAtlasiQ14410 baseline and differential
GenevisibleiQ14410 HS

Organism-specific databases

HPAiHPA060687

Interactioni

Protein-protein interaction databases

BioGridi108977, 4 interactors
IntActiQ14410, 1 interactor
STRINGi9606.ENSP00000351706

Structurei

3D structure databases

ProteinModelPortaliQ14410
SMRiQ14410
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FGGY kinase family.Curated

Phylogenomic databases

eggNOGiKOG2517 Eukaryota
COG0554 LUCA
GeneTreeiENSGT00530000063143
HOGENOMiHOG000222134
HOVERGENiHBG002451
InParanoidiQ14410
KOiK00864
OMAiFMPETTA
OrthoDBiEOG091G04EJ
PhylomeDBiQ14410
TreeFamiTF321504

Family and domain databases

InterProiView protein in InterPro
IPR000577 Carb_kinase_FGGY
IPR018485 Carb_kinase_FGGY_C
IPR018483 Carb_kinase_FGGY_CS
IPR018484 Carb_kinase_FGGY_N
IPR005999 Glycerol_kin
PfamiView protein in Pfam
PF02782 FGGY_C, 1 hit
PF00370 FGGY_N, 1 hit
PIRSFiPIRSF000538 GlpK, 1 hit
TIGRFAMsiTIGR01311 glycerol_kin, 1 hit
PROSITEiView protein in PROSITE
PS00933 FGGY_KINASES_1, 1 hit
PS00445 FGGY_KINASES_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q14410-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAPKTAAVG PLVGAVVQGT NSTRFLVFNS KTAELLSHHK VELTQEFPKE
60 70 80 90 100
GWVEQDPKEI LQSVYECIAR TCEKLDELNI DISNIKAVGV SNQRETTVIW
110 120 130 140 150
DKLTGEPLYN AVVWLDLRTQ TTVEDLSKKI PGNSNFVKSK TGLPLSTYFS
160 170 180 190 200
AVKLRWMLDN VRNVQKAVEE GRALFGTIDS WLIWSLTGGV NGGVHCTDVT
210 220 230 240 250
NASRTMLFNI HSLEWDKELC DFFEIPMDLL PNVFSSSEIY GLIKTGALEG
260 270 280 290 300
VPISGCLGDQ CAALVGQMCF QEGQAKNTYG TGCFLLCNTG RKCVFSEHGL
310 320 330 340 350
LTTVAYKLGR EKPAYYALEG SVAIAGAVIR WLRDNLGIIE TSGDIERLAK
360 370 380 390 400
EVGTSYGCYF VPAFSGLYAP YWEPSARGIL CGLTQFTNKC HIAFAALEAV
410 420 430 440 450
CFQTREILEA MNRDCGIPLR HLQVDGGMTN NKVLMQLQAD ILHIPVIKPF
460 470 480 490 500
MPETTALGAA MAAGAAEGVS VWSLEPQALS VLRMERFEPQ IQATESEIRY
510 520 530 540 550
ATWKKAVMKS MGWVTSQSPE GGDPSIFSSL PLGFFIVSSM VMLIGARYIS

GVP
Length:553
Mass (Da):60,594
Last modified:July 22, 2008 - v2
Checksum:i8CE43A0686BC4AD6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti238E → G in BAF84930 (PubMed:14702039).Curated1
Sequence conflicti369A → T in BAF84930 (PubMed:14702039).Curated1
Sequence conflicti499R → C in BAF84930 (PubMed:14702039).Curated1
Sequence conflicti528S → C in CAA55365 (PubMed:7987308).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X78712 mRNA Translation: CAA55365.1
AK292241 mRNA Translation: BAF84930.1
CH471057 Genomic DNA Translation: EAX05842.1
BC029820 mRNA Translation: AAH29820.1
BC048274 mRNA Translation: AAH48274.2
BC058888 mRNA Translation: AAH58888.1
CCDSiCCDS3585.1
PIRiI37417
RefSeqiNP_149991.2, NM_033214.2
UniGeneiHs.98008

Genome annotation databases

EnsembliENST00000358842; ENSP00000351706; ENSG00000196475
GeneIDi2712
KEGGihsa:2712
UCSCiuc003hlu.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X78712 mRNA Translation: CAA55365.1
AK292241 mRNA Translation: BAF84930.1
CH471057 Genomic DNA Translation: EAX05842.1
BC029820 mRNA Translation: AAH29820.1
BC048274 mRNA Translation: AAH48274.2
BC058888 mRNA Translation: AAH58888.1
CCDSiCCDS3585.1
PIRiI37417
RefSeqiNP_149991.2, NM_033214.2
UniGeneiHs.98008

3D structure databases

ProteinModelPortaliQ14410
SMRiQ14410
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108977, 4 interactors
IntActiQ14410, 1 interactor
STRINGi9606.ENSP00000351706

PTM databases

iPTMnetiQ14410
PhosphoSitePlusiQ14410

Polymorphism and mutation databases

BioMutaiGK2
DMDMi212286188

Proteomic databases

EPDiQ14410
MaxQBiQ14410
PaxDbiQ14410
PeptideAtlasiQ14410
PRIDEiQ14410
ProteomicsDBi59985

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000358842; ENSP00000351706; ENSG00000196475
GeneIDi2712
KEGGihsa:2712
UCSCiuc003hlu.4 human

Organism-specific databases

CTDi2712
EuPathDBiHostDB:ENSG00000196475.5
GeneCardsiGK2
H-InvDBiHIX0004328
HGNCiHGNC:4291 GK2
HPAiHPA060687
MIMi600148 gene
neXtProtiNX_Q14410
OpenTargetsiENSG00000196475
PharmGKBiPA28702
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2517 Eukaryota
COG0554 LUCA
GeneTreeiENSGT00530000063143
HOGENOMiHOG000222134
HOVERGENiHBG002451
InParanoidiQ14410
KOiK00864
OMAiFMPETTA
OrthoDBiEOG091G04EJ
PhylomeDBiQ14410
TreeFamiTF321504

Enzyme and pathway databases

UniPathwayi
UPA00618;UER00672

ReactomeiR-HSA-75109 Triglyceride biosynthesis

Miscellaneous databases

GenomeRNAii2712
PROiPR:Q14410
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000196475 Expressed in 21 organ(s), highest expression level in testis
ExpressionAtlasiQ14410 baseline and differential
GenevisibleiQ14410 HS

Family and domain databases

InterProiView protein in InterPro
IPR000577 Carb_kinase_FGGY
IPR018485 Carb_kinase_FGGY_C
IPR018483 Carb_kinase_FGGY_CS
IPR018484 Carb_kinase_FGGY_N
IPR005999 Glycerol_kin
PfamiView protein in Pfam
PF02782 FGGY_C, 1 hit
PF00370 FGGY_N, 1 hit
PIRSFiPIRSF000538 GlpK, 1 hit
TIGRFAMsiTIGR01311 glycerol_kin, 1 hit
PROSITEiView protein in PROSITE
PS00933 FGGY_KINASES_1, 1 hit
PS00445 FGGY_KINASES_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGLPK2_HUMAN
AccessioniPrimary (citable) accession number: Q14410
Secondary accession number(s): A8K876, Q6PD73, Q86XV8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: July 22, 2008
Last modified: September 12, 2018
This is version 150 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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