Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Chorionic somatomammotropin hormone-like 1

Gene

CSHL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be a novel gestational hormone required to compensate for absence of other members of the GH/CS cluster during gestation.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi44ZincBy similarity1
Metal bindingi205ZincBy similarity1

GO - Molecular functioni

  • hormone activity Source: UniProtKB
  • metal ion binding Source: UniProtKB-KW

Keywordsi

Molecular functionHormone
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Chorionic somatomammotropin hormone-like 1
Short name:
Chorionic somatomammotropin-like
Alternative name(s):
Lactogen-like
Gene namesi
Name:CSHL1
Synonyms:CSHP1, CSL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000204414.11
HGNCiHGNC:2442 CSHL1
MIMi603515 gene
neXtProtiNX_Q14406

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi1444
OpenTargetsiENSG00000204414
PharmGKBiPA26945

Polymorphism and mutation databases

BioMutaiCSHL1
DMDMi313104096

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000003295927 – 222Chorionic somatomammotropin hormone-like 1Add BLAST196

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi213 ↔ 220By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ14406
PeptideAtlasiQ14406
PRIDEiQ14406
ProteomicsDBi59980
59981 [Q14406-2]
59982 [Q14406-3]
59983 [Q14406-4]

Expressioni

Gene expression databases

BgeeiENSG00000204414
CleanExiHS_CSHL1
ExpressionAtlasiQ14406 baseline and differential
GenevisibleiQ14406 HS

Organism-specific databases

HPAiCAB025646
HPA043715

Interactioni

GO - Molecular functioni

  • hormone activity Source: UniProtKB

Protein-protein interaction databases

BioGridi107831, 2 interactors
STRINGi9606.ENSP00000309524

Structurei

3D structure databases

ProteinModelPortaliQ14406
SMRiQ14406
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the somatotropin/prolactin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IFR6 Eukaryota
ENOG4111HU8 LUCA
GeneTreeiENSGT00730000111012
HOGENOMiHOG000068443
HOVERGENiHBG011318
InParanoidiQ14406
OMAiHLHKLAF
OrthoDBiEOG091G0KPU
PhylomeDBiQ14406
TreeFamiTF332592

Family and domain databases

InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR001400 Somatotropin/Prolactin
IPR018116 Somatotropin_CS
PANTHERiPTHR11417 PTHR11417, 1 hit
PfamiView protein in Pfam
PF00103 Hormone_1, 1 hit
PRINTSiPR00836 SOMATOTROPIN
SUPFAMiSSF47266 SSF47266, 1 hit
PROSITEiView protein in PROSITE
PS00338 SOMATOTROPIN_2, 1 hit

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q14406-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAGSRTSLL LAFALLCLPW LQEAGAVQTV PLSRLFKEAM LQAHRAHQLA
60 70 80 90 100
IDTYQEFISS WGMEAYITKE QKYSFLHDSQ TSFCFSDSIP TSSNMEETQQ
110 120 130 140 150
KSNLELLHIS LLLIESRLEP VRFLRSTFTN NLVYDTSDSD DYHLLKDLEE
160 170 180 190 200
GIQMLMGRLE DGSHLTGQTL KQTYSKFDTN SHNHDALLKN YGLLHCFRKD
210 220
MDKVETFLRM VQCRSVEGSC GF
Length:222
Mass (Da):25,391
Last modified:November 30, 2010 - v2
Checksum:iE450E16D4731813A
GO
Isoform 2 (identifier: Q14406-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     64-86: Missing.

Show »
Length:199
Mass (Da):22,649
Checksum:i119656E87AFD55C3
GO
Isoform 3 (identifier: Q14406-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     4-86: Missing.

Show »
Length:139
Mass (Da):15,950
Checksum:i1F7CB63B6C869E84
GO
Isoform 4 (identifier: Q14406-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-94: Missing.

Show »
Length:128
Mass (Da):14,875
Checksum:i3EA9C8B73EBF67D5
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_059807141D → E1 PublicationCorresponds to variant dbSNP:rs2727307Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0401141 – 94Missing in isoform 4. 1 PublicationAdd BLAST94
Alternative sequenceiVSP_0401154 – 86Missing in isoform 3. CuratedAdd BLAST83
Alternative sequenceiVSP_04011664 – 86Missing in isoform 2. CuratedAdd BLAST23

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03071 Genomic DNA Translation: AAA52550.1
AC127029 Genomic DNA No translation available.
CH471109 Genomic DNA Translation: EAW94245.1
CH471109 Genomic DNA Translation: EAW94246.1
CH471109 Genomic DNA Translation: EAW94253.1
CH471109 Genomic DNA Translation: EAW94264.1
BC119747 mRNA Translation: AAI19748.1
CCDSiCCDS11652.1 [Q14406-1]
CCDS42370.1 [Q14406-4]
CCDS45759.1 [Q14406-3]
PIRiB32435
RefSeqiNP_072101.1, NM_022579.2 [Q14406-1]
NP_072102.1, NM_022580.2 [Q14406-3]
NP_072103.1, NM_022581.2 [Q14406-2]
UniGeneiHs.654390
Hs.655225

Genome annotation databases

EnsembliENST00000309894; ENSP00000309524; ENSG00000204414 [Q14406-1]
ENST00000346606; ENSP00000316360; ENSG00000204414 [Q14406-4]
ENST00000438387; ENSP00000402632; ENSG00000204414 [Q14406-3]
GeneIDi1444
KEGGihsa:1444
UCSCiuc002jda.2 human [Q14406-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCSHL_HUMAN
AccessioniPrimary (citable) accession number: Q14406
Secondary accession number(s): D3DU26, D3DU27, Q0VDB2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: November 30, 2010
Last modified: June 20, 2018
This is version 122 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health