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UniProtKB - Q14406 (CSHL_HUMAN)

Entry version 139 (10 Feb 2021)
Sequence version 2 (30 Nov 2010)
Previous versions | rss
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Protein

Chorionic somatomammotropin hormone-like 1

Gene

CSHL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be a novel gestational hormone required to compensate for absence of other members of the GH/CS cluster during gestation.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi44ZincBy similarity1
Metal bindingi205ZincBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHormone
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q14406

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Chorionic somatomammotropin hormone-like 1
Short name:
Chorionic somatomammotropin-like
Alternative name(s):
Lactogen-like
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CSHL1
Synonyms:CSHP1, CSL
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:2442, CSHL1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		603515, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q14406

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000204414.11

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		1444

Open Targets

More...OpenTargetsi		ENSG00000204414

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA26945

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q14406, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		CSHL1

Domain mapping of disease mutations (DMDM)

More...DMDMi		313104096

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 26Sequence analysisAdd BLAST26
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000003295927 – 222Chorionic somatomammotropin hormone-like 1Add BLAST196

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi213 ↔ 220By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q14406

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q14406

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q14406

PeptideAtlas

More...PeptideAtlasi		Q14406

PRoteomics IDEntifications database

More...PRIDEi		Q14406

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		59980 [Q14406-1]
59981 [Q14406-2]
59982 [Q14406-3]
59983 [Q14406-4]

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000204414, Expressed in placenta and 29 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q14406, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q14406, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000204414, Group enriched (pituitary gland, placenta)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		107831, 2 interactors

Protein interaction database and analysis system

More...IntActi		Q14406, 3 interactors

Molecular INTeraction database

More...MINTi		Q14406

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000309524

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q14406, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q14406

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the somatotropin/prolactin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502R5GJ, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00950000182818

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_088274_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q14406

Identification of Orthologs from Complete Genome Data

More...OMAi		MEAYITK

Database of Orthologous Groups

More...OrthoDBi		1190548at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q14406

TreeFam database of animal gene trees

More...TreeFami		TF332592

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR009079, 4_helix_cytokine-like_core
IPR001400, Somatotropin/Prolactin
IPR018116, Somatotropin_CS

The PANTHER Classification System

More...PANTHERi		PTHR11417, PTHR11417, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00103, Hormone_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00836, SOMATOTROPIN

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47266, SSF47266, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00338, SOMATOTROPIN_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q14406-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAGSRTSLL LAFALLCLPW LQEAGAVQTV PLSRLFKEAM LQAHRAHQLA 
        60         70         80         90        100
IDTYQEFISS WGMEAYITKE QKYSFLHDSQ TSFCFSDSIP TSSNMEETQQ 
       110        120        130        140        150
KSNLELLHIS LLLIESRLEP VRFLRSTFTN NLVYDTSDSD DYHLLKDLEE 
       160        170        180        190        200
GIQMLMGRLE DGSHLTGQTL KQTYSKFDTN SHNHDALLKN YGLLHCFRKD 
       210        220 
MDKVETFLRM VQCRSVEGSC GF
Length:222
Mass (Da):25,391
Last modified:November 30, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE450E16D4731813A
GO
Isoform 2 (identifier: Q14406-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     64-86: Missing.

Show »
Length:199
Mass (Da):22,649
Checksum:i119656E87AFD55C3
GO
Isoform 3 (identifier: Q14406-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     4-86: Missing.

Show »
Length:139
Mass (Da):15,950
Checksum:i1F7CB63B6C869E84
GO
Isoform 4 (identifier: Q14406-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-94: Missing.

Show »
Length:128
Mass (Da):14,875
Checksum:i3EA9C8B73EBF67D5
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0B4J1R0A0A0B4J1R0_HUMAN
Chorionic somatomammotropin hormone...
CSHL1
160Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QT06J3QT06_HUMAN
Chorionic somatomammotropin hormone...
CSHL1
217Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C3R7H7C3R7_HUMAN
Chorionic somatomammotropin hormone...
CSHL1
167Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YKQ4H0YKQ4_HUMAN
Chorionic somatomammotropin hormone...
CSHL1
178Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_059807141D → E1 PublicationCorresponds to variant dbSNP:rs2727307Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0401141 – 94Missing in isoform 4. 1 PublicationAdd BLAST94
Alternative sequenceiVSP_0401154 – 86Missing in isoform 3. CuratedAdd BLAST83
Alternative sequenceiVSP_04011664 – 86Missing in isoform 2. CuratedAdd BLAST23

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
J03071 Genomic DNA Translation: AAA52550.1
AC127029 Genomic DNA No translation available.
CH471109 Genomic DNA Translation: EAW94245.1
CH471109 Genomic DNA Translation: EAW94246.1
CH471109 Genomic DNA Translation: EAW94253.1
CH471109 Genomic DNA Translation: EAW94264.1
BC119747 mRNA Translation: AAI19748.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS11652.1 [Q14406-1]
CCDS42370.1 [Q14406-4]
CCDS45759.1 [Q14406-3]

Protein sequence database of the Protein Information Resource

More...PIRi		B32435

NCBI Reference Sequences

More...RefSeqi		NP_072101.1, NM_022579.2 [Q14406-1]
NP_072102.1, NM_022580.2 [Q14406-3]
NP_072103.1, NM_022581.2 [Q14406-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000309894; ENSP00000309524; ENSG00000204414 [Q14406-1]
ENST00000346606; ENSP00000316360; ENSG00000204414 [Q14406-4]
ENST00000438387; ENSP00000402632; ENSG00000204414 [Q14406-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		1444

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:1444

UCSC genome browser

More...UCSCi		uc002jda.2, human [Q14406-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03071 Genomic DNA Translation: AAA52550.1
AC127029 Genomic DNA No translation available.
CH471109 Genomic DNA Translation: EAW94245.1
CH471109 Genomic DNA Translation: EAW94246.1
CH471109 Genomic DNA Translation: EAW94253.1
CH471109 Genomic DNA Translation: EAW94264.1
BC119747 mRNA Translation: AAI19748.1
CCDSiCCDS11652.1 [Q14406-1]
CCDS42370.1 [Q14406-4]
CCDS45759.1 [Q14406-3]
PIRiB32435
RefSeqiNP_072101.1, NM_022579.2 [Q14406-1]
NP_072102.1, NM_022580.2 [Q14406-3]
NP_072103.1, NM_022581.2 [Q14406-2]

3D structure databases

SMRiQ14406
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi107831, 2 interactors
IntActiQ14406, 3 interactors
MINTiQ14406
STRINGi9606.ENSP00000309524

Genetic variation databases

BioMutaiCSHL1
DMDMi313104096

Proteomic databases

jPOSTiQ14406
MassIVEiQ14406
PaxDbiQ14406
PeptideAtlasiQ14406
PRIDEiQ14406
ProteomicsDBi59980 [Q14406-1]
59981 [Q14406-2]
59982 [Q14406-3]
59983 [Q14406-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		31484, 161 antibodies

Genome annotation databases

EnsembliENST00000309894; ENSP00000309524; ENSG00000204414 [Q14406-1]
ENST00000346606; ENSP00000316360; ENSG00000204414 [Q14406-4]
ENST00000438387; ENSP00000402632; ENSG00000204414 [Q14406-3]
GeneIDi1444
KEGGihsa:1444
UCSCiuc002jda.2, human [Q14406-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		1444
DisGeNETi1444

GeneCards: human genes, protein and diseases

More...GeneCardsi		CSHL1
HGNCiHGNC:2442, CSHL1
HPAiENSG00000204414, Group enriched (pituitary gland, placenta)
MIMi603515, gene
neXtProtiNX_Q14406
OpenTargetsiENSG00000204414
PharmGKBiPA26945
VEuPathDBiHostDB:ENSG00000204414.11

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502R5GJ, Eukaryota
GeneTreeiENSGT00950000182818
HOGENOMiCLU_088274_2_0_1
InParanoidiQ14406
OMAiMEAYITK
OrthoDBi1190548at2759
PhylomeDBiQ14406
TreeFamiTF332592

Enzyme and pathway databases

PathwayCommonsiQ14406

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		1444, 6 hits in 863 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		1444
PharosiQ14406, Tbio

Protein Ontology

More...PROi		PR:Q14406
RNActiQ14406, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000204414, Expressed in placenta and 29 other tissues
ExpressionAtlasiQ14406, baseline and differential
GenevisibleiQ14406, HS

Family and domain databases

InterProiView protein in InterPro
IPR009079, 4_helix_cytokine-like_core
IPR001400, Somatotropin/Prolactin
IPR018116, Somatotropin_CS
PANTHERiPTHR11417, PTHR11417, 1 hit
PfamiView protein in Pfam
PF00103, Hormone_1, 1 hit
PRINTSiPR00836, SOMATOTROPIN
SUPFAMiSSF47266, SSF47266, 1 hit
PROSITEiView protein in PROSITE
PS00338, SOMATOTROPIN_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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MobiDB: a database of protein disorder and mobility annotations

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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCSHL_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q14406
Secondary accession number(s): D3DU26, D3DU27, Q0VDB2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: November 30, 2010
Last modified: February 10, 2021
This is version 139 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human variants curated from literature reports
    Index of human variants curated from literature reports
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  5. Human entries with genetic variants
    List of human entries with genetic variants
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