UniProtKB - Q14406 (CSHL_HUMAN)
Protein
Chorionic somatomammotropin hormone-like 1
Gene
CSHL1
Organism
Homo sapiens (Human)
Status
Functioni
May be a novel gestational hormone required to compensate for absence of other members of the GH/CS cluster during gestation.1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 44 | ZincBy similarity | 1 | |
Metal bindingi | 205 | ZincBy similarity | 1 |
GO - Molecular functioni
- growth factor activity Source: GO_Central
- growth hormone receptor binding Source: GO_Central
- hormone activity Source: GO_Central
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- animal organ development Source: GO_Central
- growth hormone receptor signaling pathway Source: GO_Central
- positive regulation of growth Source: GO_Central
- positive regulation of receptor signaling pathway via JAK-STAT Source: GO_Central
- positive regulation of tyrosine phosphorylation of STAT protein Source: GO_Central
- response to nutrient levels Source: GO_Central
Keywordsi
Molecular function | Hormone |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q14406 |
Names & Taxonomyi
Protein namesi | Recommended name: Chorionic somatomammotropin hormone-like 1Short name: Chorionic somatomammotropin-like Alternative name(s): Lactogen-like |
Gene namesi | Name:CSHL1 Synonyms:CSHP1, CSL |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:2442, CSHL1 |
MIMi | 603515, gene |
neXtProti | NX_Q14406 |
VEuPathDBi | HostDB:ENSG00000204414.11 |
Subcellular locationi
Extracellular region or secreted
- Secreted 1 Publication
Extracellular region or secreted
- extracellular space Source: GO_Central
Keywords - Cellular componenti
SecretedPathology & Biotechi
Organism-specific databases
DisGeNETi | 1444 |
OpenTargetsi | ENSG00000204414 |
PharmGKBi | PA26945 |
Miscellaneous databases
Pharosi | Q14406, Tbio |
Genetic variation databases
BioMutai | CSHL1 |
DMDMi | 313104096 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 26 | Sequence analysisAdd BLAST | 26 | |
ChainiPRO_0000032959 | 27 – 222 | Chorionic somatomammotropin hormone-like 1Add BLAST | 196 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 213 ↔ 220 | By similarity |
Keywords - PTMi
Disulfide bondProteomic databases
jPOSTi | Q14406 |
MassIVEi | Q14406 |
PaxDbi | Q14406 |
PeptideAtlasi | Q14406 |
PRIDEi | Q14406 |
ProteomicsDBi | 59980 [Q14406-1] 59981 [Q14406-2] 59982 [Q14406-3] 59983 [Q14406-4] |
Expressioni
Gene expression databases
Bgeei | ENSG00000204414, Expressed in placenta and 29 other tissues |
ExpressionAtlasi | Q14406, baseline and differential |
Genevisiblei | Q14406, HS |
Organism-specific databases
HPAi | ENSG00000204414, Group enriched (pituitary gland, placenta) |
Interactioni
GO - Molecular functioni
- growth factor activity Source: GO_Central
- growth hormone receptor binding Source: GO_Central
- hormone activity Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 107831, 2 interactors |
IntActi | Q14406, 3 interactors |
MINTi | Q14406 |
STRINGi | 9606.ENSP00000309524 |
Miscellaneous databases
RNActi | Q14406, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the somatotropin/prolactin family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502R5GJ, Eukaryota |
GeneTreei | ENSGT00950000182818 |
HOGENOMi | CLU_088274_2_0_1 |
InParanoidi | Q14406 |
OMAi | MEAYITK |
OrthoDBi | 1190548at2759 |
PhylomeDBi | Q14406 |
TreeFami | TF332592 |
Family and domain databases
InterProi | View protein in InterPro IPR009079, 4_helix_cytokine-like_core IPR001400, Somatotropin/Prolactin IPR018116, Somatotropin_CS |
PANTHERi | PTHR11417, PTHR11417, 1 hit |
Pfami | View protein in Pfam PF00103, Hormone_1, 1 hit |
PRINTSi | PR00836, SOMATOTROPIN |
SUPFAMi | SSF47266, SSF47266, 1 hit |
PROSITEi | View protein in PROSITE PS00338, SOMATOTROPIN_2, 1 hit |
s (4+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q14406-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAAGSRTSLL LAFALLCLPW LQEAGAVQTV PLSRLFKEAM LQAHRAHQLA
60 70 80 90 100
IDTYQEFISS WGMEAYITKE QKYSFLHDSQ TSFCFSDSIP TSSNMEETQQ
110 120 130 140 150
KSNLELLHIS LLLIESRLEP VRFLRSTFTN NLVYDTSDSD DYHLLKDLEE
160 170 180 190 200
GIQMLMGRLE DGSHLTGQTL KQTYSKFDTN SHNHDALLKN YGLLHCFRKD
210 220
MDKVETFLRM VQCRSVEGSC GF
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0B4J1R0 | A0A0B4J1R0_HUMAN | Chorionic somatomammotropin hormone... | CSHL1 | 160 | Annotation score: | ||
J3QT06 | J3QT06_HUMAN | Chorionic somatomammotropin hormone... | CSHL1 | 217 | Annotation score: | ||
H7C3R7 | H7C3R7_HUMAN | Chorionic somatomammotropin hormone... | CSHL1 | 167 | Annotation score: | ||
H0YKQ4 | H0YKQ4_HUMAN | Chorionic somatomammotropin hormone... | CSHL1 | 178 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_059807 | 141 | D → E1 PublicationCorresponds to variant dbSNP:rs2727307Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_040114 | 1 – 94 | Missing in isoform 4. 1 PublicationAdd BLAST | 94 | |
Alternative sequenceiVSP_040115 | 4 – 86 | Missing in isoform 3. CuratedAdd BLAST | 83 | |
Alternative sequenceiVSP_040116 | 64 – 86 | Missing in isoform 2. CuratedAdd BLAST | 23 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J03071 Genomic DNA Translation: AAA52550.1 AC127029 Genomic DNA No translation available. CH471109 Genomic DNA Translation: EAW94245.1 CH471109 Genomic DNA Translation: EAW94246.1 CH471109 Genomic DNA Translation: EAW94253.1 CH471109 Genomic DNA Translation: EAW94264.1 BC119747 mRNA Translation: AAI19748.1 |
CCDSi | CCDS11652.1 [Q14406-1] CCDS42370.1 [Q14406-4] CCDS45759.1 [Q14406-3] |
PIRi | B32435 |
RefSeqi | NP_072101.1, NM_022579.2 [Q14406-1] NP_072102.1, NM_022580.2 [Q14406-3] NP_072103.1, NM_022581.2 [Q14406-2] |
Genome annotation databases
Ensembli | ENST00000309894; ENSP00000309524; ENSG00000204414 [Q14406-1] ENST00000346606; ENSP00000316360; ENSG00000204414 [Q14406-4] ENST00000438387; ENSP00000402632; ENSG00000204414 [Q14406-3] |
GeneIDi | 1444 |
KEGGi | hsa:1444 |
UCSCi | uc002jda.2, human [Q14406-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J03071 Genomic DNA Translation: AAA52550.1 AC127029 Genomic DNA No translation available. CH471109 Genomic DNA Translation: EAW94245.1 CH471109 Genomic DNA Translation: EAW94246.1 CH471109 Genomic DNA Translation: EAW94253.1 CH471109 Genomic DNA Translation: EAW94264.1 BC119747 mRNA Translation: AAI19748.1 |
CCDSi | CCDS11652.1 [Q14406-1] CCDS42370.1 [Q14406-4] CCDS45759.1 [Q14406-3] |
PIRi | B32435 |
RefSeqi | NP_072101.1, NM_022579.2 [Q14406-1] NP_072102.1, NM_022580.2 [Q14406-3] NP_072103.1, NM_022581.2 [Q14406-2] |
3D structure databases
SMRi | Q14406 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 107831, 2 interactors |
IntActi | Q14406, 3 interactors |
MINTi | Q14406 |
STRINGi | 9606.ENSP00000309524 |
Genetic variation databases
BioMutai | CSHL1 |
DMDMi | 313104096 |
Proteomic databases
jPOSTi | Q14406 |
MassIVEi | Q14406 |
PaxDbi | Q14406 |
PeptideAtlasi | Q14406 |
PRIDEi | Q14406 |
ProteomicsDBi | 59980 [Q14406-1] 59981 [Q14406-2] 59982 [Q14406-3] 59983 [Q14406-4] |
Protocols and materials databases
Antibodypediai | 31484, 161 antibodies |
Genome annotation databases
Ensembli | ENST00000309894; ENSP00000309524; ENSG00000204414 [Q14406-1] ENST00000346606; ENSP00000316360; ENSG00000204414 [Q14406-4] ENST00000438387; ENSP00000402632; ENSG00000204414 [Q14406-3] |
GeneIDi | 1444 |
KEGGi | hsa:1444 |
UCSCi | uc002jda.2, human [Q14406-1] |
Organism-specific databases
CTDi | 1444 |
DisGeNETi | 1444 |
GeneCardsi | CSHL1 |
HGNCi | HGNC:2442, CSHL1 |
HPAi | ENSG00000204414, Group enriched (pituitary gland, placenta) |
MIMi | 603515, gene |
neXtProti | NX_Q14406 |
OpenTargetsi | ENSG00000204414 |
PharmGKBi | PA26945 |
VEuPathDBi | HostDB:ENSG00000204414.11 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502R5GJ, Eukaryota |
GeneTreei | ENSGT00950000182818 |
HOGENOMi | CLU_088274_2_0_1 |
InParanoidi | Q14406 |
OMAi | MEAYITK |
OrthoDBi | 1190548at2759 |
PhylomeDBi | Q14406 |
TreeFami | TF332592 |
Enzyme and pathway databases
PathwayCommonsi | Q14406 |
Miscellaneous databases
BioGRID-ORCSi | 1444, 6 hits in 863 CRISPR screens |
GenomeRNAii | 1444 |
Pharosi | Q14406, Tbio |
PROi | PR:Q14406 |
RNActi | Q14406, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000204414, Expressed in placenta and 29 other tissues |
ExpressionAtlasi | Q14406, baseline and differential |
Genevisiblei | Q14406, HS |
Family and domain databases
InterProi | View protein in InterPro IPR009079, 4_helix_cytokine-like_core IPR001400, Somatotropin/Prolactin IPR018116, Somatotropin_CS |
PANTHERi | PTHR11417, PTHR11417, 1 hit |
Pfami | View protein in Pfam PF00103, Hormone_1, 1 hit |
PRINTSi | PR00836, SOMATOTROPIN |
SUPFAMi | SSF47266, SSF47266, 1 hit |
PROSITEi | View protein in PROSITE PS00338, SOMATOTROPIN_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CSHL_HUMAN | |
Accessioni | Q14406Primary (citable) accession number: Q14406 Secondary accession number(s): D3DU26, D3DU27, Q0VDB2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 19, 2005 |
Last sequence update: | November 30, 2010 | |
Last modified: | February 10, 2021 | |
This is version 139 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants