UniProtKB - Q14397 (GCKR_HUMAN)

BLAST

>sp|Q14397|GCKR_HUMAN Glucokinase regulatory protein OS=Homo sapiens OX=9606 GN=GCKR PE=1 SV=6
MPGTKRFQHVIETPEPGKWELSGYEAAVPITEKSNPLTQDLDKADAENIVRLLGQCDAEI
FQEEGQALSTYQRLYSESILTTMVQVAGKVQEVLKEPDGGLVVLSGGGTSGRMAFLMSVS
FNQLMKGLGQKPLYTYLIAGGDRSVVASREGTEDSALHGIEELKKVAAGKKRVIVIGISV
GLSAPFVAGQMDCCMNNTAVFLPVLVGFNPVSMARNDPIEDWSSTFRQVAERMQKMQEKQ
KAFVLNPAIGPEGLSGSSRMKGGSATKILLETLLLAAHKTVDQGIAASQRCLLEILRTFE
RAHQVTYSQSPKIATLMKSVSTSLEKKGHVYLVGWQTLGIIAIMDGVECIHTFGADFRDV
RGFLIGDHSDMFNQKAELTNQGPQFTFSQEDFLTSILPSLTEIDTVVFIFTLDDNLTEVQ
TIVEQVKEKTNHIQALAHSTVGQTLPIPLKKLFPSIISITWPLLFFEYEGNFIQKFQREL
STKWVLNTVSTGAHVLLGKILQNHMLDLRISNSKLFWRALAMLQRFSGQSKARCIESLLR
AIHFPQPLSDDIRAAPISCHVQVAHEKEQVIPIALLSLLFRCSITEAQAHLAAAPSVCEA
VRSALAGPGQKRTADPLEILEPDVQ

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History
Entry version 146 (12 Sep 2018)
Sequence version 6 (05 Apr 2011)
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Protein

Glucokinase regulatory protein

Gene

GCKR

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Inhibits glucokinase (GCK) by forming an inactive complex with this enzyme. The affinity of GCKR for GCK is modulated by fructose metabolites: GCKR with bound fructose 6-phosphate has increased affinity for GCK, while GCKR with bound fructose 1-phosphate has strongly decreased affinity for GCK and does not inhibit GCK activity.2 Publications

Sites

Feature key	Position(s)	DescriptionActions	Length
Binding siteⁱ	153	Fructose 1-phosphate	1
Binding siteⁱ	348	Fructose 1-phosphate	1
Binding siteⁱ	514	Fructose 1-phosphate/Fructose 6-phosphate	1

GO - Molecular functionⁱ

fructose-6-phosphate binding
Source: UniProtKB
Inferred from direct assayⁱ
- 23621087

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

carbohydrate derivative metabolic process Source: InterPro
carbohydrate metabolic process Source: UniProtKB-KW
negative regulation of glucokinase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 23621087
protein import into nucleus, translocation Source: BHF-UCL
regulation of glycolytic process Source: Reactome
response to fructose
Source: BHF-UCL
Inferred from direct assayⁱ
- 14627435
triglyceride homeostasis
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 19526250
- 20668700
urate metabolic process
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 19503597

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Carbohydrate metabolism

Biological process

Carbohydrate metabolism

Enzyme and pathway databases

Reactomeⁱ	R-HSA-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-5619107 Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)

Reactomeⁱ

R-HSA-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein
R-HSA-5619107 Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Glucokinase regulatory protein Short name: GKRP Short name: Glucokinase regulator
Gene namesⁱ	Name:GCKR
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 2

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000084734.8
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:4196 GCKR
MIMⁱ	600842 gene
neXtProtⁱ	NX_Q14397

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	326 – 327	KK → TT: No effect on inhibition of glucokinase. 1 Publication	2
Mutagenesisⁱ	413	D → A: Impairs inhibition of glucokinase. 1 Publication	1
Mutagenesisⁱ	450 – 451	KK → TT: Impairs inhibition of glucokinase. 1 Publication	2
Mutagenesisⁱ	463 – 465	LLF → ALA: Abolishes interaction with GCK. Abolishes inhibition of GCK. 1 Publication	3

Organism-specific databases

DisGeNET More...DisGeNETⁱ	2646
MalaCards human disease database More...MalaCardsⁱ	GCKR
MIMⁱ	613463 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000084734
PharmGKBⁱ	PA28611

Chemistry databases

ChEMBLⁱ	CHEMBL1075152

ChEMBLⁱ

CHEMBL1075152

Polymorphism and mutation databases

BioMutaⁱ	GCKR
DMDMⁱ	327478611

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000214826	1 – 625	Glucokinase regulatory proteinAdd BLAST		625

Proteomic databases

EPDⁱ	Q14397
PaxDbⁱ	Q14397
PeptideAtlas More...PeptideAtlasⁱ	Q14397
PRIDEⁱ	Q14397
ProteomicsDBⁱ	59979

PTM databases

iPTMnetⁱ	Q14397
PhosphoSitePlusⁱ	Q14397

Expressionⁱ

Tissue specificityⁱ

Found in liver and pancreas. Not detected in muscle, brain, heart, thymus, intestine, uterus, adipose tissue, kidney, adrenal, lung or spleen.2 Publications

Gene expression databases

Bgeeⁱ	ENSG00000084734 Expressed in 84 organ(s), highest expression level in right lobe of liver
CleanExⁱ	HS_GCKR
ExpressionAtlasⁱ	Q14397 baseline and differential

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA064305

HPAⁱ

HPA064305

Interactionⁱ

Subunit structureⁱ

Interacts (fructose 6-phosphate bound form) with GCK.3 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
GCK	P35557	2	EBI-709948,EBI-709928

With

Entry

#Exp.

IntAct

Notes

GCK

P35557

EBI-709948,EBI-709928

Protein-protein interaction databases

BioGridⁱ	108916, 6 interactors
IntActⁱ	Q14397, 2 interactors
STRINGⁱ	9606.ENSP00000264717

Chemistry databases

BindingDBⁱ

Q14397

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Turnⁱ	2 – 4	Combined sources	3
Helixⁱ	5 – 7	Combined sources	3
Turnⁱ	19 – 22	Combined sources	4
Helixⁱ	23 – 26	Combined sources	4
Helixⁱ	30 – 32	Combined sources	3
Helixⁱ	36 – 38	Combined sources	3
Helixⁱ	41 – 43	Combined sources	3
Helixⁱ	46 – 58	Combined sources	13
Helixⁱ	59 – 61	Combined sources	3
Helixⁱ	77 – 94	Combined sources	18
Beta strandⁱ	100 – 107	Combined sources	8
Helixⁱ	108 – 127	Combined sources	20
Beta strandⁱ	134 – 138	Combined sources	5
Helixⁱ	143 – 146	Combined sources	4
Helixⁱ	150 – 154	Combined sources	5
Helixⁱ	156 – 167	Combined sources	12
Beta strandⁱ	171 – 178	Combined sources	8
Helixⁱ	185 – 195	Combined sources	11
Turnⁱ	198 – 200	Combined sources	3
Beta strandⁱ	201 – 206	Combined sources	6
Helixⁱ	211 – 213	Combined sources	3
Beta strandⁱ	222 – 224	Combined sources	3
Helixⁱ	226 – 237	Combined sources	12
Turnⁱ	238 – 240	Combined sources	3
Beta strandⁱ	243 – 245	Combined sources	3
Turnⁱ	258 – 260	Combined sources	3
Helixⁱ	261 – 283	Combined sources	23
Helixⁱ	289 – 307	Combined sources	19
Helixⁱ	310 – 325	Combined sources	16
Beta strandⁱ	330 – 335	Combined sources	6
Helixⁱ	337 – 353	Combined sources	17
Beta strandⁱ	359 – 366	Combined sources	8
Turnⁱ	369 – 371	Combined sources	3
Helixⁱ	375 – 377	Combined sources	3
Turnⁱ	378 – 380	Combined sources	3
Helixⁱ	383 – 385	Combined sources	3
Helixⁱ	389 – 395	Combined sources	7
Helixⁱ	397 – 399	Combined sources	3
Beta strandⁱ	405 – 411	Combined sources	7
Helixⁱ	416 – 427	Combined sources	12
Beta strandⁱ	433 – 440	Combined sources	8
Helixⁱ	447 – 452	Combined sources	6
Beta strandⁱ	453 – 455	Combined sources	3
Beta strandⁱ	457 – 461	Combined sources	5
Turnⁱ	467 – 469	Combined sources	3
Helixⁱ	470 – 495	Combined sources	26
Turnⁱ	496 – 498	Combined sources	3
Helixⁱ	513 – 527	Combined sources	15
Helixⁱ	531 – 543	Combined sources	13
Helixⁱ	550 – 553	Combined sources	4
Helixⁱ	557 – 564	Combined sources	8
Beta strandⁱ	567 – 569	Combined sources	3
Helixⁱ	570 – 580	Combined sources	11
Helixⁱ	584 – 592	Combined sources	9
Beta strandⁱ	594 – 596	Combined sources	3
Helixⁱ	597 – 605	Combined sources	9

Show more details

3D structure databases

ProteinModelPortalⁱ	Q14397
SMRⁱ	Q14397
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	90 – 286	SIS 1PROSITE-ProRule annotationAdd BLAST		197
Domainⁱ	320 – 499	SIS 2PROSITE-ProRule annotationAdd BLAST		180

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	109 – 110	Fructose 1-phosphate/Fructose 6-phosphate binding	2
Regionⁱ	179 – 181	Fructose 1-phosphate/Fructose 6-phosphate binding	3
Regionⁱ	199 – 200	Important for interaction with GCKBy similarity	2
Regionⁱ	463 – 465	Essential for interaction with GCK	3

Domainⁱ

Fructose 1-phosphate and fructose 6-phosphate compete for the same binding site.

Sequence similaritiesⁱ

Belongs to the GCKR family.Curated

Keywords - Domainⁱ

Repeat

Phylogenomic databases

eggNOGⁱ	ENOG410IHMK Eukaryota ENOG4111GRB LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000005345
HOGENOMⁱ	HOG000031501
HOVERGENⁱ	HBG005818
InParanoidⁱ	Q14397
PhylomeDBⁱ	Q14397
TreeFamⁱ	TF329177

Family and domain databases

InterProⁱ	View protein in InterPro IPR005486 Glucokinase_regulatory_CS IPR001347 SIS
PROSITEⁱ	View protein in PROSITE PS01272 GCKR, 1 hit PS51464 SIS, 2 hits

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q14397-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPGTKRFQHV IETPEPGKWE LSGYEAAVPI TEKSNPLTQD LDKADAENIV 
        60         70         80         90        100
RLLGQCDAEI FQEEGQALST YQRLYSESIL TTMVQVAGKV QEVLKEPDGG 
       110        120        130        140        150
LVVLSGGGTS GRMAFLMSVS FNQLMKGLGQ KPLYTYLIAG GDRSVVASRE 
       160        170        180        190        200
GTEDSALHGI EELKKVAAGK KRVIVIGISV GLSAPFVAGQ MDCCMNNTAV 
       210        220        230        240        250
FLPVLVGFNP VSMARNDPIE DWSSTFRQVA ERMQKMQEKQ KAFVLNPAIG 
       260        270        280        290        300
PEGLSGSSRM KGGSATKILL ETLLLAAHKT VDQGIAASQR CLLEILRTFE 
       310        320        330        340        350
RAHQVTYSQS PKIATLMKSV STSLEKKGHV YLVGWQTLGI IAIMDGVECI 
       360        370        380        390        400
HTFGADFRDV RGFLIGDHSD MFNQKAELTN QGPQFTFSQE DFLTSILPSL 
       410        420        430        440        450
TEIDTVVFIF TLDDNLTEVQ TIVEQVKEKT NHIQALAHST VGQTLPIPLK 
       460        470        480        490        500
KLFPSIISIT WPLLFFEYEG NFIQKFQREL STKWVLNTVS TGAHVLLGKI 
       510        520        530        540        550
LQNHMLDLRI SNSKLFWRAL AMLQRFSGQS KARCIESLLR AIHFPQPLSD 
       560        570        580        590        600
DIRAAPISCH VQVAHEKEQV IPIALLSLLF RCSITEAQAH LAAAPSVCEA 
       610        620 
VRSALAGPGQ KRTADPLEIL EPDVQ

Length:625

Mass (Da):68,685

Last modified:April 5, 2011 - v6

Checksum:ⁱDE750462AC603C80

Isoform 2 (identifier: Q14397-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
144-150: SVVASRE → WLPGRRE
151-625: Missing.

« Hide

        10         20         30         40         50
MPGTKRFQHV IETPEPGKWE LSGYEAAVPI TEKSNPLTQD LDKADAENIV 
        60         70         80         90        100
RLLGQCDAEI FQEEGQALST YQRLYSESIL TTMVQVAGKV QEVLKEPDGG 
       110        120        130        140        150
LVVLSGGGTS GRMAFLMSVS FNQLMKGLGQ KPLYTYLIAG GDRWLPGRRE

Note: No experimental confirmation available.

Show »

Length:150

Mass (Da):16,477

Checksum:ⁱB958AFB4A930F3B1

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

A0A0C4DFN2	A0A0C4DFN2_HUMAN	Glucokinase (Hexokinase 4) regulato... Glucokinase (Hexokinase 4) regulator (Glucokinase regulatory protein)	GCKR hCG_21226	625	Annotation score:
H7C1B4	H7C1B4_HUMAN	Glucokinase regulatory protein Glucokinase regulatory protein	GCKR	227	Annotation score:
H7C4D3	H7C4D3_HUMAN	Glucokinase regulatory protein Glucokinase regulatory protein	GCKR	189	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	251	P → V in CAB61828 (PubMed:9570959).Curated	1
Sequence conflictⁱ	393	L → P in CAA88367 (PubMed:8589523).Curated	1
Sequence conflictⁱ	560	H → R in CAA88367 (PubMed:8589523).Curated	1

Polymorphismⁱ

Genetic variations in GCKR define the fasting plasma glucose levels quantitative trait locus 5 (FGQTL5) [MIMⁱ:613463]. The normal fasting plasma glucose level is defined as less than 100 mg glucose per deciliter plasma (5.55 mmol per liter). Higher fasting plasma glucose levels predict type 2 diabetes in young adults and increases the risk of mortality.

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_018849	77	E → G1 PublicationCorresponds to variant dbSNP:rs8179206EnsemblClinVar.	1
Natural variantⁱVAR_018850	256	G → S1 PublicationCorresponds to variant dbSNP:rs8179212Ensembl.	1
Natural variantⁱVAR_008906	446	P → L Associated with high triglyceride levels and low fasting plasma glucose levels; associated with a reduced risk for type 2 diabetes; the mutant protein is less efficiently regulated by physiological concentrations of fructose-6 phosphate. 5 PublicationsCorresponds to variant dbSNP:rs1260326Ensembl.	1
Natural variantⁱVAR_018851	540	R → Q1 PublicationCorresponds to variant dbSNP:rs8179249Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_054853	144 – 150	SVVASRE → WLPGRRE in isoform 2. 1 Publication		7
Alternative sequenceⁱVSP_054854	151 – 625	Missing in isoform 2. 1 PublicationAdd BLAST		475

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Z48475 mRNA Translation: CAA88367.1 Y09593 Genomic DNA Translation: CAA70779.2 Y09592 Genomic DNA Translation: CAB61828.1 AY320034 Genomic DNA Translation: AAP72013.1 AK298448 mRNA Translation: BAG60664.1 AC074117 Genomic DNA Translation: AAY14850.1 BC130481 mRNA Translation: AAI30482.1 BC130483 mRNA Translation: AAI30484.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS1757.1 [Q14397-1]
PIRⁱ	S52485
NCBI Reference Sequences More...RefSeqⁱ	NP_001477.2, NM_001486.3
UniGeneⁱ	Hs.89771

Genome annotation databases

Ensemblⁱ	ENST00000417872; ENSP00000398303; ENSG00000084734 [Q14397-2]
GeneIDⁱ	2646
KEGGⁱ	hsa:2646
UCSC genome browser More...UCSCⁱ	uc002rky.4 human [Q14397-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q14397	Uncharacterized protein		CERAT		631	UniRef90_Q14397
Glucokinase (Hexokinase 4) regulator		HUMAN		625
GCKR isoform 1		PANTR		625
Uncharacterized protein		NOMLE		625
Uncharacterized protein		AILME		625
+66
Q14397-2	GCKR isoform 2		PONAB		150	UniRef90_Q14397-2
UPI00083F6F02		CALJA		146

Protein	Similar proteins		Species	Score	Length	Source
Q14397	Glucokinase regulatory protein	)	RAT		627	UniRef50_Q14397
Uncharacterized protein		CERAT		631
Glucokinase regulator		PONAB		625
Uncharacterized protein		NOMLE		625
Glucokinase regulator		MACFA		625
+125
Q14397-2	GCKR isoform 2		PONAB		150	UniRef50_Q14397-2
glucokinase regulatory protein-like		Enhydra lutris kenyoni		162
UPI00083F6F02		CALJA		146

Cross-referencesⁱ

Web resourcesⁱ

NIEHS-SNPs

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Z48475 mRNA Translation: CAA88367.1 Y09593 Genomic DNA Translation: CAA70779.2 Y09592 Genomic DNA Translation: CAB61828.1 AY320034 Genomic DNA Translation: AAP72013.1 AK298448 mRNA Translation: BAG60664.1 AC074117 Genomic DNA Translation: AAY14850.1 BC130481 mRNA Translation: AAI30482.1 BC130483 mRNA Translation: AAI30484.1
CCDSⁱ	CCDS1757.1 [Q14397-1]
PIRⁱ	S52485
RefSeqⁱ	NP_001477.2, NM_001486.3
UniGeneⁱ	Hs.89771

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	4BB9	X-ray	1.47	A	1-625	[»]
	4BBA	X-ray	1.92	A	1-625	[»]
	4LY9	X-ray	2.35	A/B	1-625	[»]
	4MQU	X-ray	2.22	A/B	1-625	[»]
	4MRO	X-ray	2.20	A/B	1-625	[»]
	4MSU	X-ray	2.50	A/B	1-625	[»]
	4OHK	X-ray	2.80	A/B	1-625	[»]
	4OHM	X-ray	2.40	A/B	1-625	[»]
	4OHO	X-ray	2.58	A/B	1-625	[»]
	4OHP	X-ray	2.40	A/B	1-625	[»]
	4OLH	X-ray	2.40	A/B	1-625	[»]
	4OP1	X-ray	2.39	A/B	1-625	[»]
	4OP2	X-ray	2.24	A/B	1-625	[»]
	4OP3	X-ray	2.82	A/B	1-625	[»]
	4PX2	X-ray	2.15	A/B	1-625	[»]
	4PX3	X-ray	2.43	A/B	1-625	[»]
	4PX5	X-ray	2.20	A/B	1-625	[»]
	4PXS	X-ray	2.60	A/B	1-625	[»]
ProteinModelPortalⁱ	Q14397
SMRⁱ	Q14397
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	108916, 6 interactors
IntActⁱ	Q14397, 2 interactors
STRINGⁱ	9606.ENSP00000264717

Chemistry databases

BindingDBⁱ	Q14397
ChEMBLⁱ	CHEMBL1075152

PTM databases

iPTMnetⁱ	Q14397
PhosphoSitePlusⁱ	Q14397

Polymorphism and mutation databases

BioMutaⁱ	GCKR
DMDMⁱ	327478611

Proteomic databases

EPDⁱ	Q14397
PaxDbⁱ	Q14397
PeptideAtlasⁱ	Q14397
PRIDEⁱ	Q14397
ProteomicsDBⁱ	59979

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	2646
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000417872; ENSP00000398303; ENSG00000084734 [Q14397-2]
GeneIDⁱ	2646
KEGGⁱ	hsa:2646
UCSCⁱ	uc002rky.4 human [Q14397-1]

Organism-specific databases

CTDⁱ	2646
DisGeNETⁱ	2646
EuPathDBⁱ	HostDB:ENSG00000084734.8
GeneCardsⁱ	GCKR
H-InvDBⁱ	HIX0030026
HGNCⁱ	HGNC:4196 GCKR
HPAⁱ	HPA064305
MalaCardsⁱ	GCKR
MIMⁱ	600842 gene 613463 phenotype
neXtProtⁱ	NX_Q14397
OpenTargetsⁱ	ENSG00000084734
PharmGKBⁱ	PA28611
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IHMK Eukaryota ENOG4111GRB LUCA
GeneTreeⁱ	ENSGT00390000005345
HOGENOMⁱ	HOG000031501
HOVERGENⁱ	HBG005818
InParanoidⁱ	Q14397
PhylomeDBⁱ	Q14397
TreeFamⁱ	TF329177

Enzyme and pathway databases

Reactomeⁱ	R-HSA-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-5619107 Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)

Reactomeⁱ

R-HSA-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein
R-HSA-5619107 Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)

Miscellaneous databases

ChiTaRSⁱ	GCKR human
GenomeRNAiⁱ	2646
Protein Ontology More...PROⁱ	PR:Q14397
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000084734 Expressed in 84 organ(s), highest expression level in right lobe of liver
CleanExⁱ	HS_GCKR
ExpressionAtlasⁱ	Q14397 baseline and differential

Family and domain databases

InterProⁱ	View protein in InterPro IPR005486 Glucokinase_regulatory_CS IPR001347 SIS
PROSITEⁱ	View protein in PROSITE PS01272 GCKR, 1 hit PS51464 SIS, 2 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	GCKR_HUMAN
Accessionⁱ	Q14397Primary (citable) accession number: Q14397 Secondary accession number(s): A1L4C2 , B4DPQ2, Q53RY6, Q99522
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
	Last sequence update:	April 5, 2011
	Last modified:	September 12, 2018
	This is version 146 of the entry and version 6 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
SIMILARITY comments
Index of protein domains and families
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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Supporting data

UniProtKB - Q14397 (GCKR_HUMAN)

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Glucokinase regulatory protein

GCKR

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Cytosol

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ