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UniProtKB - Q14397 (GCKR_HUMAN)

Entry version 150 (13 Feb 2019)
Sequence version 6 (05 Apr 2011)
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Protein

Glucokinase regulatory protein

Gene

GCKR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Inhibits glucokinase (GCK) by forming an inactive complex with this enzyme. The affinity of GCKR for GCK is modulated by fructose metabolites: GCKR with bound fructose 6-phosphate has increased affinity for GCK, while GCKR with bound fructose 1-phosphate has strongly decreased affinity for GCK and does not inhibit GCK activity.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei153Fructose 1-phosphate1
Binding sitei348Fructose 1-phosphate1
Binding sitei514Fructose 1-phosphate/Fructose 6-phosphate1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • carbohydrate binding Source: GO_Central
  • enzyme binding Source: GO_Central
  • enzyme inhibitor activity Source: GO_Central
  • fructose-6-phosphate binding Source: UniProtKB
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCarbohydrate metabolism

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein
R-HSA-5619107 Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Glucokinase regulatory protein
Short name:
GKRP
Short name:
Glucokinase regulator
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GCKR
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000084734.8

Human Gene Nomenclature Database

More...HGNCi		HGNC:4196 GCKR

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		600842 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q14397

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi326 – 327KK → TT: No effect on inhibition of glucokinase. 1 Publication2
Mutagenesisi413D → A: Impairs inhibition of glucokinase. 1 Publication1
Mutagenesisi450 – 451KK → TT: Impairs inhibition of glucokinase. 1 Publication2
Mutagenesisi463 – 465LLF → ALA: Abolishes interaction with GCK. Abolishes inhibition of GCK. 1 Publication3

Organism-specific databases

DisGeNET

More...DisGeNETi		2646

MalaCards human disease database

More...MalaCardsi		GCKR
MIMi613463 phenotype

Open Targets

More...OpenTargetsi		ENSG00000084734

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA28611

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL1075152

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		GCKR

Domain mapping of disease mutations (DMDM)

More...DMDMi		327478611

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002148261 – 625Glucokinase regulatory proteinAdd BLAST625

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q14397

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q14397

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q14397

PeptideAtlas

More...PeptideAtlasi		Q14397

PRoteomics IDEntifications database

More...PRIDEi		Q14397

ProteomicsDB human proteome resource

More...ProteomicsDBi		59979

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q14397

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q14397

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Found in liver and pancreas. Not detected in muscle, brain, heart, thymus, intestine, uterus, adipose tissue, kidney, adrenal, lung or spleen.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000084734 Expressed in 84 organ(s), highest expression level in right lobe of liver

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q14397 baseline and differential

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA064305

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (fructose 6-phosphate bound form) with GCK.3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
GCKP355572EBI-709948,EBI-709928

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		108916, 6 interactors

Protein interaction database and analysis system

More...IntActi		Q14397, 2 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000264717

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		Q14397

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1625
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4BB9X-ray1.47A1-625[»]
4BBAX-ray1.92A1-625[»]
4LY9X-ray2.35A/B1-625[»]
4MQUX-ray2.22A/B1-625[»]
4MROX-ray2.20A/B1-625[»]
4MSUX-ray2.50A/B1-625[»]
4OHKX-ray2.80A/B1-625[»]
4OHMX-ray2.40A/B1-625[»]
4OHOX-ray2.58A/B1-625[»]
4OHPX-ray2.40A/B1-625[»]
4OLHX-ray2.40A/B1-625[»]
4OP1X-ray2.39A/B1-625[»]
4OP2X-ray2.24A/B1-625[»]
4OP3X-ray2.82A/B1-625[»]
4PX2X-ray2.15A/B1-625[»]
4PX3X-ray2.43A/B1-625[»]
4PX5X-ray2.20A/B1-625[»]
4PXSX-ray2.60A/B1-625[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...ProteinModelPortali		Q14397

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q14397

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini90 – 286SIS 1PROSITE-ProRule annotationAdd BLAST197
Domaini320 – 499SIS 2PROSITE-ProRule annotationAdd BLAST180

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni109 – 110Fructose 1-phosphate/Fructose 6-phosphate binding2
Regioni179 – 181Fructose 1-phosphate/Fructose 6-phosphate binding3
Regioni199 – 200Important for interaction with GCKBy similarity2
Regioni463 – 465Essential for interaction with GCK3

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Fructose 1-phosphate and fructose 6-phosphate compete for the same binding site.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the GCKR family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG410IHMK Eukaryota
ENOG4111GRB LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00390000005345

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000031501

The HOVERGEN Database of Homologous Vertebrate Genes

More...HOVERGENi		HBG005818

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q14397

Database of Orthologous Groups

More...OrthoDBi		858819at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q14397

TreeFam database of animal gene trees

More...TreeFami		TF329177

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR005486 Glucokinase_regulatory_CS
IPR040190 MURQ/GCKR
IPR001347 SIS

The PANTHER Classification System

More...PANTHERi		PTHR10088 PTHR10088, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS01272 GCKR, 1 hit
PS51464 SIS, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q14397-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPGTKRFQHV IETPEPGKWE LSGYEAAVPI TEKSNPLTQD LDKADAENIV 
        60         70         80         90        100
RLLGQCDAEI FQEEGQALST YQRLYSESIL TTMVQVAGKV QEVLKEPDGG 
       110        120        130        140        150
LVVLSGGGTS GRMAFLMSVS FNQLMKGLGQ KPLYTYLIAG GDRSVVASRE 
       160        170        180        190        200
GTEDSALHGI EELKKVAAGK KRVIVIGISV GLSAPFVAGQ MDCCMNNTAV 
       210        220        230        240        250
FLPVLVGFNP VSMARNDPIE DWSSTFRQVA ERMQKMQEKQ KAFVLNPAIG 
       260        270        280        290        300
PEGLSGSSRM KGGSATKILL ETLLLAAHKT VDQGIAASQR CLLEILRTFE 
       310        320        330        340        350
RAHQVTYSQS PKIATLMKSV STSLEKKGHV YLVGWQTLGI IAIMDGVECI 
       360        370        380        390        400
HTFGADFRDV RGFLIGDHSD MFNQKAELTN QGPQFTFSQE DFLTSILPSL 
       410        420        430        440        450
TEIDTVVFIF TLDDNLTEVQ TIVEQVKEKT NHIQALAHST VGQTLPIPLK 
       460        470        480        490        500
KLFPSIISIT WPLLFFEYEG NFIQKFQREL STKWVLNTVS TGAHVLLGKI 
       510        520        530        540        550
LQNHMLDLRI SNSKLFWRAL AMLQRFSGQS KARCIESLLR AIHFPQPLSD 
       560        570        580        590        600
DIRAAPISCH VQVAHEKEQV IPIALLSLLF RCSITEAQAH LAAAPSVCEA 
       610        620 
VRSALAGPGQ KRTADPLEIL EPDVQ
Length:625
Mass (Da):68,685
Last modified:April 5, 2011 - v6
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDE750462AC603C80
GO
Isoform 2 (identifier: Q14397-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     144-150: SVVASRE → WLPGRRE
     151-625: Missing.

Note: No experimental confirmation available.
Show »
Length:150
Mass (Da):16,477
Checksum:iB958AFB4A930F3B1
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0C4DFN2A0A0C4DFN2_HUMAN
Glucokinase (Hexokinase 4) regulato...
GCKR hCG_21226
625Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C1B4H7C1B4_HUMAN
Glucokinase regulatory protein
GCKR
227Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C4D3H7C4D3_HUMAN
Glucokinase regulatory protein
GCKR
189Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti251P → V in CAB61828 (PubMed:9570959).Curated1
Sequence conflicti393L → P in CAA88367 (PubMed:8589523).Curated1
Sequence conflicti560H → R in CAA88367 (PubMed:8589523).Curated1

<p>This subsection of the ‘Sequence’ section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement_in_disease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

Genetic variations in GCKR define the fasting plasma glucose levels quantitative trait locus 5 (FGQTL5) [MIMi:613463]. The normal fasting plasma glucose level is defined as less than 100 mg glucose per deciliter plasma (5.55 mmol per liter). Higher fasting plasma glucose levels predict type 2 diabetes in young adults and increases the risk of mortality.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01884977E → G1 PublicationCorresponds to variant dbSNP:rs8179206EnsemblClinVar.1
Natural variantiVAR_018850256G → S1 PublicationCorresponds to variant dbSNP:rs8179212Ensembl.1
Natural variantiVAR_008906446P → L Associated with high triglyceride levels and low fasting plasma glucose levels; associated with a reduced risk for type 2 diabetes; the mutant protein is less efficiently regulated by physiological concentrations of fructose-6 phosphate. 5 PublicationsCorresponds to variant dbSNP:rs1260326Ensembl.1
Natural variantiVAR_018851540R → Q1 PublicationCorresponds to variant dbSNP:rs8179249Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_054853144 – 150SVVASRE → WLPGRRE in isoform 2. 1 Publication7
Alternative sequenceiVSP_054854151 – 625Missing in isoform 2. 1 PublicationAdd BLAST475

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
Z48475 mRNA Translation: CAA88367.1
Y09593 Genomic DNA Translation: CAA70779.2
Y09592 Genomic DNA Translation: CAB61828.1
AY320034 Genomic DNA Translation: AAP72013.1
AK298448 mRNA Translation: BAG60664.1
AC074117 Genomic DNA Translation: AAY14850.1
BC130481 mRNA Translation: AAI30482.1
BC130483 mRNA Translation: AAI30484.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS1757.1 [Q14397-1]

Protein sequence database of the Protein Information Resource

More...PIRi		S52485

NCBI Reference Sequences

More...RefSeqi		NP_001477.2, NM_001486.3

UniGene gene-oriented nucleotide sequence clusters

More...UniGenei		Hs.89771

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000417872; ENSP00000398303; ENSG00000084734 [Q14397-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		2646

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:2646

UCSC genome browser

More...UCSCi		uc002rky.4 human [Q14397-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z48475 mRNA Translation: CAA88367.1
Y09593 Genomic DNA Translation: CAA70779.2
Y09592 Genomic DNA Translation: CAB61828.1
AY320034 Genomic DNA Translation: AAP72013.1
AK298448 mRNA Translation: BAG60664.1
AC074117 Genomic DNA Translation: AAY14850.1
BC130481 mRNA Translation: AAI30482.1
BC130483 mRNA Translation: AAI30484.1
CCDSiCCDS1757.1 [Q14397-1]
PIRiS52485
RefSeqiNP_001477.2, NM_001486.3
UniGeneiHs.89771

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4BB9X-ray1.47A1-625[»]
4BBAX-ray1.92A1-625[»]
4LY9X-ray2.35A/B1-625[»]
4MQUX-ray2.22A/B1-625[»]
4MROX-ray2.20A/B1-625[»]
4MSUX-ray2.50A/B1-625[»]
4OHKX-ray2.80A/B1-625[»]
4OHMX-ray2.40A/B1-625[»]
4OHOX-ray2.58A/B1-625[»]
4OHPX-ray2.40A/B1-625[»]
4OLHX-ray2.40A/B1-625[»]
4OP1X-ray2.39A/B1-625[»]
4OP2X-ray2.24A/B1-625[»]
4OP3X-ray2.82A/B1-625[»]
4PX2X-ray2.15A/B1-625[»]
4PX3X-ray2.43A/B1-625[»]
4PX5X-ray2.20A/B1-625[»]
4PXSX-ray2.60A/B1-625[»]
ProteinModelPortaliQ14397
SMRiQ14397
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108916, 6 interactors
IntActiQ14397, 2 interactors
STRINGi9606.ENSP00000264717

Chemistry databases

BindingDBiQ14397
ChEMBLiCHEMBL1075152

PTM databases

iPTMnetiQ14397
PhosphoSitePlusiQ14397

Polymorphism and mutation databases

BioMutaiGCKR
DMDMi327478611

Proteomic databases

EPDiQ14397
jPOSTiQ14397
PaxDbiQ14397
PeptideAtlasiQ14397
PRIDEiQ14397
ProteomicsDBi59979

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		2646
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000417872; ENSP00000398303; ENSG00000084734 [Q14397-2]
GeneIDi2646
KEGGihsa:2646
UCSCiuc002rky.4 human [Q14397-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		2646
DisGeNETi2646
EuPathDBiHostDB:ENSG00000084734.8

GeneCards: human genes, protein and diseases

More...GeneCardsi		GCKR

H-Invitational Database, human transcriptome db

More...H-InvDBi		HIX0030026
HGNCiHGNC:4196 GCKR
HPAiHPA064305
MalaCardsiGCKR
MIMi600842 gene
613463 phenotype
neXtProtiNX_Q14397
OpenTargetsiENSG00000084734
PharmGKBiPA28611

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG410IHMK Eukaryota
ENOG4111GRB LUCA
GeneTreeiENSGT00390000005345
HOGENOMiHOG000031501
HOVERGENiHBG005818
InParanoidiQ14397
OrthoDBi858819at2759
PhylomeDBiQ14397
TreeFamiTF329177

Enzyme and pathway databases

ReactomeiR-HSA-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein
R-HSA-5619107 Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		GCKR human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		2646

Protein Ontology

More...PROi		PR:Q14397

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000084734 Expressed in 84 organ(s), highest expression level in right lobe of liver
ExpressionAtlasiQ14397 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR005486 Glucokinase_regulatory_CS
IPR040190 MURQ/GCKR
IPR001347 SIS
PANTHERiPTHR10088 PTHR10088, 1 hit
PROSITEiView protein in PROSITE
PS01272 GCKR, 1 hit
PS51464 SIS, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGCKR_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q14397
Secondary accession number(s): A1L4C2
, B4DPQ2, Q53RY6, Q99522
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: April 5, 2011
Last modified: February 13, 2019
This is version 150 of the entry and version 6 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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