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UniProtKB - Q14393 (GAS6_HUMAN)

Protein

Growth arrest-specific protein 6

Gene

GAS6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses.2 Publications
(Microbial infection) Can bridges virus envelope phosphatidylserine to the TAM receptor tyrosine kinase Axl to mediate viral entry by apoptotic mimicry (PubMed:21501828). Plays a role in Dengue cell entry by apoptotic mimicry (PubMed:23084921). Plays a role in Vaccinia virus cell entry by apoptotic mimicry (PubMed:21501828). Plays a role in ebolavirus and marburgvirus cell entry by apoptotic mimicry (PubMed:17005688).3 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi329Calcium1
Metal bindingi331Calcium; via carbonyl oxygen1
Metal bindingi440Calcium; via carbonyl oxygen1
Metal bindingi656Calcium1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processGrowth regulation, Host-virus interaction
LigandCalcium, Metal-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-114608 Platelet degranulation
R-HSA-159740 Gamma-carboxylation of protein precursors
R-HSA-159763 Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus
R-HSA-159782 Removal of aminoterminal propeptides from gamma-carboxylated proteins
R-HSA-202733 Cell surface interactions at the vascular wall
R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-8957275 Post-translational protein phosphorylation

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q14393

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q14393

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Growth arrest-specific protein 6Curated
Short name:
GAS-6
Alternative name(s):
AXL receptor tyrosine kinase ligand
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GAS6Imported
Synonyms:AXLLG
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 13

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000183087.14

Human Gene Nomenclature Database

More...HGNCi		HGNC:4168 GAS6

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		600441 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q14393

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi310R → E: Strongly reduced affinity for AXL. Abolishes phosphorylation of AXL. 1 Publication1
Mutagenesisi312K → E: Strongly reduced affinity for AXL. Abolishes phosphorylation of AXL. 1 Publication1
Mutagenesisi487F → A: Decreases activation of AXL. 1 Publication1
Mutagenesisi620L → A: Reduces affinity for AXL 15-fold and decreases activation of AXL. 1 Publication1
Mutagenesisi660Y → A: Reduces affinity for AXL 3-fold. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		2621

Open Targets

More...OpenTargetsi		ENSG00000183087

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA28582

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		GAS6

Domain mapping of disease mutations (DMDM)

More...DMDMi		48427995

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 30Sequence analysisAdd BLAST30
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000758931 – 678Growth arrest-specific protein 6Add BLAST648

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi65 ↔ 70By similarity
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei71Phosphoserine; by FAM20C1 Publication1
Disulfide bondi120 ↔ 133By similarity
Disulfide bondi125 ↔ 142By similarity
Disulfide bondi144 ↔ 153By similarity
Disulfide bondi160 ↔ 171By similarity
Disulfide bondi167 ↔ 180By similarity
Disulfide bondi182 ↔ 195By similarity
Disulfide bondi201 ↔ 212By similarity
Disulfide bondi207 ↔ 221By similarity
Disulfide bondi223 ↔ 236By similarity
Disulfide bondi242 ↔ 251By similarity
Disulfide bondi247 ↔ 260By similarity
Disulfide bondi262 ↔ 277
Disulfide bondi283 ↔ 570
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi420N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi444 ↔ 470
Modified residuei621PhosphothreonineBy similarity1
Modified residuei637PhosphothreonineBy similarity1
Modified residuei640PhosphotyrosineBy similarity1
Disulfide bondi643 ↔ 670

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Isoform 2: Proteolytically processed after secretion to yield a N-terminal 36 kDa protein and a C-terminal 50 kDa protein including the laminin G-like domains which activates AXL.1 Publication
Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium.PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Gamma-carboxyglutamic acid, Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q14393

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q14393

PeptideAtlas

More...PeptideAtlasi		Q14393

PRoteomics IDEntifications database

More...PRIDEi		Q14393

ProteomicsDB human proteome resource

More...ProteomicsDBi		59975
59976 [Q14393-2]
59977 [Q14393-3]
59978 [Q14393-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q14393

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q14393

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Plasma. Isoform 1 and isoform 2 are widely expressed, isoform 1 being expressed at higher levels than isoform 2 in most tissues. Isoform 2 is the predominant form in spleen.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000183087 Expressed in 225 organ(s), highest expression level in thoracic aorta

CleanEx database of gene expression profiles

More...CleanExi		HS_GAS6

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q14393 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA008275
HPA056080

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer and heterotetramer with AXL.1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
AXLP305308EBI-20753849,EBI-2850927

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		108891, 33 interactors

Protein interaction database and analysis system

More...IntActi		Q14393, 13 interactors

Molecular INTeraction database

More...MINTi		Q14393

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1678
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...ProteinModelPortali		Q14393

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q14393

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q14393

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini53 – 94GlaPROSITE-ProRule annotationAdd BLAST42
Domaini116 – 154EGF-like 1; calcium-bindingPROSITE-ProRule annotationAdd BLAST39
Domaini156 – 196EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd BLAST41
Domaini197 – 237EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd BLAST41
Domaini238 – 278EGF-like 4; calcium-bindingPROSITE-ProRule annotationAdd BLAST41
Domaini298 – 470Laminin G-like 1PROSITE-ProRule annotationAdd BLAST173
Domaini477 – 670Laminin G-like 2PROSITE-ProRule annotationAdd BLAST194

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

Ensembl GeneTree

More...GeneTreei		ENSGT00940000161271

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000065758

The HOVERGEN Database of Homologous Vertebrate Genes

More...HOVERGENi		HBG051702

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q14393

KEGG Orthology (KO)

More...KOi		K05464

Identification of Orthologs from Complete Genome Data

More...OMAi		DEAAYKH

Database of Orthologous Groups

More...OrthoDBi		EOG091G034Z

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q14393

TreeFam database of animal gene trees

More...TreeFami		TF352157

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		4.10.740.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR026823 cEGF
IPR017857 Coagulation_fac-like_Gla_dom
IPR013320 ConA-like_dom_sf
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR035972 GLA-like_dom_SF
IPR000294 GLA_domain
IPR009030 Growth_fac_rcpt_cys_sf
IPR001791 Laminin_G

Pfam protein domain database

More...Pfami		View protein in Pfam
PF12662 cEGF, 1 hit
PF07645 EGF_CA, 1 hit
PF00594 Gla, 1 hit
PF12661 hEGF, 2 hits
PF00054 Laminin_G_1, 1 hit
PF02210 Laminin_G_2, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00001 GLABLOOD

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00181 EGF, 4 hits
SM00179 EGF_CA, 4 hits
SM00069 GLA, 1 hit
SM00282 LamG, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF49899 SSF49899, 2 hits
SSF57184 SSF57184, 1 hit
SSF57630 SSF57630, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00010 ASX_HYDROXYL, 4 hits
PS00022 EGF_1, 1 hit
PS01186 EGF_2, 3 hits
PS50026 EGF_3, 4 hits
PS01187 EGF_CA, 3 hits
PS00011 GLA_1, 1 hit
PS50998 GLA_2, 1 hit
PS50025 LAM_G_DOMAIN, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q14393-2) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAPSLSPGPA ALRRAPQLLL LLLAAECALA ALLPAREATQ FLRPRQRRAF 
        60         70         80         90        100
QVFEEAKQGH LERECVEELC SREEAREVFE NDPETDYFYP RYLDCINKYG 
       110        120        130        140        150
SPYTKNSGFA TCVQNLPDQC TPNPCDRKGT QACQDLMGNF FCLCKAGWGG 
       160        170        180        190        200
RLCDKDVNEC SQENGGCLQI CHNKPGSFHC SCHSGFELSS DGRTCQDIDE 
       210        220        230        240        250
CADSEACGEA RCKNLPGSYS CLCDEGFAYS SQEKACRDVD ECLQGRCEQV 
       260        270        280        290        300
CVNSPGSYTC HCDGRGGLKL SQDMDTCEDI LPCVPFSVAK SVKSLYLGRM 
       310        320        330        340        350
FSGTPVIRLR FKRLQPTRLV AEFDFRTFDP EGILLFAGGH QDSTWIVLAL 
       360        370        380        390        400
RAGRLELQLR YNGVGRVTSS GPVINHGMWQ TISVEELARN LVIKVNRDAV 
       410        420        430        440        450
MKIAVAGDLF QPERGLYHLN LTVGGIPFHE KDLVQPINPR LDGCMRSWNW 
       460        470        480        490        500
LNGEDTTIQE TVKVNTRMQC FSVTERGSFY PGSGFAFYSL DYMRTPLDVG 
       510        520        530        540        550
TESTWEVEVV AHIRPAADTG VLFALWAPDL RAVPLSVALV DYHSTKKLKK 
       560        570        580        590        600
QLVVLAVEHT ALALMEIKVC DGQEHVVTVS LRDGEATLEV DGTRGQSEVS 
       610        620        630        640        650
AAQLQERLAV LERHLRSPVL TFAGGLPDVP VTSAPVTAFY RGCMTLEVNR 
       660        670 
RLLDLDEAAY KHSDITAHSC PPVEPAAA
Length:678
Mass (Da):74,925
Last modified:September 12, 2018 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBB6D8AB0F6C48EA9
GO
Isoform 2 (identifier: Q14393-1) [UniParc]FASTAAdd to basket
Also known as: gas6SV1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     278-278: E → ELEAGWPCPRHRRDGSPAARPGRGAQGSRSEGHIPDRRGPRPWQ

Show »
Length:721
Mass (Da):79,677
Checksum:iE7B22B0E010930F9
GO
Isoform 3 (identifier: Q14393-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-94: MAPSLSPGPA...TDYFYPRYLD → MCMCQASPPP...AFSKAEWLSN

Note: No experimental confirmation available.
Show »
Length:624
Mass (Da):68,256
Checksum:i6CCEBDDE139C9F53
GO
Isoform 4 (identifier: Q14393-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-273: Missing.

Show »
Length:405
Mass (Da):44,841
Checksum:iECF30C620FA69B60
GO
Isoform 5 (identifier: Q14393-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-299: Missing.

Note: No experimental confirmation available.
Show »
Length:379
Mass (Da):41,986
Checksum:iA0EE62BA476927C6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti356E → K in BAG52469 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03882341F → L1 Publication1
Natural variantiVAR_038824231S → Y1 PublicationCorresponds to variant dbSNP:rs146159446Ensembl.1
Natural variantiVAR_038825347V → M1 Publication1
Natural variantiVAR_038826500G → R1 Publication1
Natural variantiVAR_038827580S → L1 Publication1
Natural variantiVAR_038828612E → K1 Publication1
Natural variantiVAR_038829616R → Q1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0597671 – 299Missing in isoform 5. Add BLAST299
Alternative sequenceiVSP_0597681 – 273Missing in isoform 4. Add BLAST273
Alternative sequenceiVSP_0597691 – 94MAPSL…PRYLD → MCMCQASPPPAALAGCLLSS CVQPAREHGGAFSKAEWLSN in isoform 3. Add BLAST94
Alternative sequenceiVSP_059770278E → ELEAGWPCPRHRRDGSPAAR PGRGAQGSRSEGHIPDRRGP RPWQ in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
L13720 mRNA Translation: AAA58494.1
AY256843
, AY256830, AY256831, AY256832, AY256833, AY256834, AY256835, AY256836, AY256837, AY256838, AY256839, AY256840, AY256841, AY256842 Genomic DNA Translation: AAO84057.1
AK092028 mRNA Translation: BAG52469.1
AK122969 mRNA Translation: BAG53826.1
AK126533 mRNA Translation: BAC86580.1
AK290803 mRNA Translation: BAF83492.1
EF631974 Genomic DNA Translation: ABR09277.1
BX072579 Genomic DNA No translation available.
BC038984 mRNA Translation: AAH38984.1
AY170372 Genomic DNA Translation: AAO41859.1
BK001240 Genomic DNA Translation: DAA01155.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS45072.1 [Q14393-2]

Protein sequence database of the Protein Information Resource

More...PIRi		B48089

NCBI Reference Sequences

More...RefSeqi		NP_000811.1, NM_000820.3 [Q14393-2]

UniGene gene-oriented nucleotide sequence clusters

More...UniGenei		Hs.646346

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000327773; ENSP00000331831; ENSG00000183087 [Q14393-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		2621

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:2621

UCSC genome browser

More...UCSCi		uc001vud.4 human [Q14393-2]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L13720 mRNA Translation: AAA58494.1
AY256843
, AY256830, AY256831, AY256832, AY256833, AY256834, AY256835, AY256836, AY256837, AY256838, AY256839, AY256840, AY256841, AY256842 Genomic DNA Translation: AAO84057.1
AK092028 mRNA Translation: BAG52469.1
AK122969 mRNA Translation: BAG53826.1
AK126533 mRNA Translation: BAC86580.1
AK290803 mRNA Translation: BAF83492.1
EF631974 Genomic DNA Translation: ABR09277.1
BX072579 Genomic DNA No translation available.
BC038984 mRNA Translation: AAH38984.1
AY170372 Genomic DNA Translation: AAO41859.1
BK001240 Genomic DNA Translation: DAA01155.1
CCDSiCCDS45072.1 [Q14393-2]
PIRiB48089
RefSeqiNP_000811.1, NM_000820.3 [Q14393-2]
UniGeneiHs.646346

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1H30X-ray2.20A261-678[»]
2C5DX-ray3.30A/B261-678[»]
4RA0X-ray3.07A/B279-678[»]
5VXZX-ray2.30A/B281-675[»]
ProteinModelPortaliQ14393
SMRiQ14393
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108891, 33 interactors
IntActiQ14393, 13 interactors
MINTiQ14393

PTM databases

iPTMnetiQ14393
PhosphoSitePlusiQ14393

Polymorphism and mutation databases

BioMutaiGAS6
DMDMi48427995

Proteomic databases

EPDiQ14393
MaxQBiQ14393
PeptideAtlasiQ14393
PRIDEiQ14393
ProteomicsDBi59975
59976 [Q14393-2]
59977 [Q14393-3]
59978 [Q14393-4]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000327773; ENSP00000331831; ENSG00000183087 [Q14393-2]
GeneIDi2621
KEGGihsa:2621
UCSCiuc001vud.4 human [Q14393-2]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		2621
DisGeNETi2621
EuPathDBiHostDB:ENSG00000183087.14

GeneCards: human genes, protein and diseases

More...GeneCardsi		GAS6
HGNCiHGNC:4168 GAS6
HPAiHPA008275
HPA056080
MIMi600441 gene
neXtProtiNX_Q14393
OpenTargetsiENSG00000183087
PharmGKBiPA28582

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

GeneTreeiENSGT00940000161271
HOGENOMiHOG000065758
HOVERGENiHBG051702
InParanoidiQ14393
KOiK05464
OMAiDEAAYKH
OrthoDBiEOG091G034Z
PhylomeDBiQ14393
TreeFamiTF352157

Enzyme and pathway databases

ReactomeiR-HSA-114608 Platelet degranulation
R-HSA-159740 Gamma-carboxylation of protein precursors
R-HSA-159763 Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus
R-HSA-159782 Removal of aminoterminal propeptides from gamma-carboxylated proteins
R-HSA-202733 Cell surface interactions at the vascular wall
R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-8957275 Post-translational protein phosphorylation
SignaLinkiQ14393
SIGNORiQ14393

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		GAS6 human
EvolutionaryTraceiQ14393

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		GAS6

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		2621

Protein Ontology

More...PROi		PR:Q14393

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000183087 Expressed in 225 organ(s), highest expression level in thoracic aorta
CleanExiHS_GAS6
GenevisibleiQ14393 HS

Family and domain databases

Gene3Di4.10.740.10, 1 hit
InterProiView protein in InterPro
IPR026823 cEGF
IPR017857 Coagulation_fac-like_Gla_dom
IPR013320 ConA-like_dom_sf
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR035972 GLA-like_dom_SF
IPR000294 GLA_domain
IPR009030 Growth_fac_rcpt_cys_sf
IPR001791 Laminin_G
PfamiView protein in Pfam
PF12662 cEGF, 1 hit
PF07645 EGF_CA, 1 hit
PF00594 Gla, 1 hit
PF12661 hEGF, 2 hits
PF00054 Laminin_G_1, 1 hit
PF02210 Laminin_G_2, 1 hit
PRINTSiPR00001 GLABLOOD
SMARTiView protein in SMART
SM00181 EGF, 4 hits
SM00179 EGF_CA, 4 hits
SM00069 GLA, 1 hit
SM00282 LamG, 2 hits
SUPFAMiSSF49899 SSF49899, 2 hits
SSF57184 SSF57184, 1 hit
SSF57630 SSF57630, 1 hit
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 4 hits
PS00022 EGF_1, 1 hit
PS01186 EGF_2, 3 hits
PS50026 EGF_3, 4 hits
PS01187 EGF_CA, 3 hits
PS00011 GLA_1, 1 hit
PS50998 GLA_2, 1 hit
PS50025 LAM_G_DOMAIN, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGAS6_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q14393
Secondary accession number(s): B3KRQ7
, B3KVL4, E9PBL7, Q6IMN1, Q7Z7N3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: September 12, 2018
Last modified: December 5, 2018
This is version 191 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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