UniProtKB - Q14393 (GAS6_HUMAN)
Protein
Growth arrest-specific protein 6
Gene
GAS6
Organism
Homo sapiens (Human)
Status
Functioni
Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses.2 Publications
(Microbial infection) Can bridge virus envelope phosphatidylserine to the TAM receptor tyrosine kinase Axl to mediate viral entry by apoptotic mimicry (PubMed:21501828). Plays a role in Dengue cell entry by apoptotic mimicry (PubMed:23084921). Plays a role in Vaccinia virus cell entry by apoptotic mimicry (PubMed:21501828). Plays a role in ebolavirus and marburgvirus cell entry by apoptotic mimicry (PubMed:17005688).3 Publications
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 329 | Calcium | 1 | |
Metal bindingi | 331 | Calcium; via carbonyl oxygen | 1 | |
Metal bindingi | 440 | Calcium; via carbonyl oxygen | 1 | |
Metal bindingi | 656 | Calcium | 1 |
GO - Molecular functioni
- calcium ion binding Source: InterPro
- cysteine-type endopeptidase inhibitor activity involved in apoptotic process Source: UniProtKB
- phosphatidylserine binding Source: UniProtKB
- protein-macromolecule adaptor activity Source: UniProtKB
- protein tyrosine kinase activator activity Source: UniProtKB
- receptor ligand activity Source: MGI
- receptor tyrosine kinase binding Source: UniProtKB
- signaling receptor binding Source: UniProtKB
GO - Biological processi
- activation of protein kinase B activity Source: UniProtKB
- animal organ regeneration Source: Ensembl
- apoptotic cell clearance Source: UniProtKB
- B cell chemotaxis Source: UniProtKB
- blood coagulation Source: Ensembl
- calcium ion transmembrane transport Source: UniProtKB
- cell-substrate adhesion Source: Ensembl
- cellular protein metabolic process Source: Reactome
- cellular response to drug Source: UniProtKB
- cellular response to glucose stimulus Source: UniProtKB
- cellular response to growth factor stimulus Source: Ensembl
- cellular response to interferon-alpha Source: UniProtKB
- cellular response to starvation Source: Ensembl
- cellular response to vitamin K Source: UniProtKB
- dendritic cell differentiation Source: UniProtKB
- endoplasmic reticulum to Golgi vesicle-mediated transport Source: Reactome
- enzyme linked receptor protein signaling pathway Source: Ensembl
- extracellular matrix assembly Source: UniProtKB
- fusion of virus membrane with host plasma membrane Source: UniProtKB
- hematopoietic stem cell migration to bone marrow Source: UniProtKB
- leukocyte migration Source: Reactome
- negative regulation of apoptotic process Source: UniProtKB
- negative regulation of biomineral tissue development Source: UniProtKB
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB
- negative regulation of dendritic cell apoptotic process Source: UniProtKB
- negative regulation of DNA-binding transcription factor activity Source: UniProtKB
- negative regulation of endothelial cell apoptotic process Source: UniProtKB
- negative regulation of fibroblast apoptotic process Source: UniProtKB
- negative regulation of interferon-gamma production Source: UniProtKB
- negative regulation of interleukin-1 production Source: UniProtKB
- negative regulation of interleukin-6 production Source: UniProtKB
- negative regulation of oligodendrocyte apoptotic process Source: UniProtKB
- negative regulation of renal albumin absorption Source: UniProtKB
- negative regulation of transcription, DNA-templated Source: UniProtKB
- negative regulation of tumor necrosis factor-mediated signaling pathway Source: UniProtKB
- negative regulation of tumor necrosis factor production Source: UniProtKB
- neuron migration Source: Ensembl
- peptidyl-serine phosphorylation Source: UniProtKB
- phagocytosis Source: UniProtKB
- platelet degranulation Source: Reactome
- positive regulation of cytokine-mediated signaling pathway Source: UniProtKB
- positive regulation of dendritic cell chemotaxis Source: UniProtKB
- positive regulation of ERK1 and ERK2 cascade Source: MGI
- positive regulation of fibroblast proliferation Source: UniProtKB
- positive regulation of gene expression Source: UniProtKB
- positive regulation of glomerular filtration Source: UniProtKB
- positive regulation of natural killer cell differentiation Source: UniProtKB
- positive regulation of peptidyl-serine phosphorylation Source: UniProtKB
- positive regulation of phagocytosis Source: UniProtKB
- positive regulation of protein export from nucleus Source: UniProtKB
- positive regulation of protein kinase activity Source: UniProtKB
- positive regulation of protein kinase B signaling Source: UniProtKB
- positive regulation of protein phosphorylation Source: UniProtKB
- positive regulation of protein tyrosine kinase activity Source: UniProtKB
- positive regulation of TOR signaling Source: UniProtKB
- post-translational protein modification Source: Reactome
- protein kinase B signaling Source: UniProtKB
- protein localization to plasma membrane Source: UniProtKB
- protein phosphorylation Source: UniProtKB
- receptor-mediated virion attachment to host cell Source: UniProtKB
- regulation of growth Source: UniProtKB-KW
- signal transduction Source: UniProtKB
- viral entry into host cell Source: UniProtKB
- viral genome replication Source: UniProtKB
Keywordsi
Biological process | Growth regulation, Host-virus interaction |
Ligand | Calcium, Metal-binding |
Enzyme and pathway databases
PathwayCommonsi | Q14393 |
Reactomei | R-HSA-114608, Platelet degranulation R-HSA-159740, Gamma-carboxylation of protein precursors R-HSA-159763, Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus R-HSA-159782, Removal of aminoterminal propeptides from gamma-carboxylated proteins R-HSA-202733, Cell surface interactions at the vascular wall R-HSA-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-8957275, Post-translational protein phosphorylation |
SignaLinki | Q14393 |
SIGNORi | Q14393 |
Names & Taxonomyi
Protein namesi | Recommended name: Growth arrest-specific protein 6CuratedShort name: GAS-6 Alternative name(s): AXL receptor tyrosine kinase ligand |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:4168, GAS6 |
MIMi | 600441, gene |
neXtProti | NX_Q14393 |
VEuPathDBi | HostDB:ENSG00000183087.14 |
Subcellular locationi
Extracellular region or secreted
- Secreted 1 Publication
Endoplasmic reticulum
- endoplasmic reticulum lumen Source: Reactome
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
- extracellular region Source: Reactome
- extracellular space Source: UniProtKB
Golgi apparatus
- Golgi lumen Source: Reactome
Other locations
- cytoplasm Source: UniProtKB
- platelet alpha granule lumen Source: Reactome
Keywords - Cellular componenti
SecretedPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 310 | R → E: Strongly reduced affinity for AXL. Abolishes phosphorylation of AXL. 1 Publication | 1 | |
Mutagenesisi | 312 | K → E: Strongly reduced affinity for AXL. Abolishes phosphorylation of AXL. 1 Publication | 1 | |
Mutagenesisi | 487 | F → A: Decreases activation of AXL. 1 Publication | 1 | |
Mutagenesisi | 620 | L → A: Reduces affinity for AXL 15-fold and decreases activation of AXL. 1 Publication | 1 | |
Mutagenesisi | 660 | Y → A: Reduces affinity for AXL 3-fold. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 2621 |
OpenTargetsi | ENSG00000183087 |
PharmGKBi | PA28582 |
Miscellaneous databases
Pharosi | Q14393, Tbio |
Genetic variation databases
BioMutai | GAS6 |
DMDMi | 48427995 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 30 | Sequence analysisAdd BLAST | 30 | |
ChainiPRO_0000007589 | 31 – 678 | Growth arrest-specific protein 6Add BLAST | 648 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 65 ↔ 70 | By similarity | ||
Modified residuei | 71 | Phosphoserine; by FAM20C1 Publication | 1 | |
Disulfide bondi | 120 ↔ 133 | By similarity | ||
Disulfide bondi | 125 ↔ 142 | By similarity | ||
Disulfide bondi | 144 ↔ 153 | By similarity | ||
Disulfide bondi | 160 ↔ 171 | By similarity | ||
Disulfide bondi | 167 ↔ 180 | By similarity | ||
Disulfide bondi | 182 ↔ 195 | By similarity | ||
Disulfide bondi | 201 ↔ 212 | By similarity | ||
Disulfide bondi | 207 ↔ 221 | By similarity | ||
Disulfide bondi | 223 ↔ 236 | By similarity | ||
Disulfide bondi | 242 ↔ 251 | By similarity | ||
Disulfide bondi | 247 ↔ 260 | By similarity | ||
Disulfide bondi | 262 ↔ 277 | |||
Disulfide bondi | 283 ↔ 570 | |||
Glycosylationi | 420 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Disulfide bondi | 444 ↔ 470 | |||
Modified residuei | 621 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 637 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 640 | PhosphotyrosineBy similarity | 1 | |
Disulfide bondi | 643 ↔ 670 |
Post-translational modificationi
Proteolytically processed after secretion to yield a N-terminal 36 kDa protein and a C-terminal 50 kDa protein including the laminin G-like domains which activates AXL.1 Publication
Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium.PROSITE-ProRule annotation
Keywords - PTMi
Disulfide bond, Gamma-carboxyglutamic acid, Glycoprotein, PhosphoproteinProteomic databases
EPDi | Q14393 |
jPOSTi | Q14393 |
MassIVEi | Q14393 |
MaxQBi | Q14393 |
PeptideAtlasi | Q14393 |
PRIDEi | Q14393 |
ProteomicsDBi | 19251 59975 [Q14393-1] 59976 [Q14393-2] 59977 [Q14393-3] 59978 [Q14393-4] |
PTM databases
GlyGeni | Q14393, 1 site |
iPTMneti | Q14393 |
PhosphoSitePlusi | Q14393 |
Expressioni
Tissue specificityi
Plasma. Isoform 1 and isoform 2 are widely expressed, isoform 1 being expressed at higher levels than isoform 2 in most tissues. Isoform 2 is the predominant form in spleen.2 Publications
Gene expression databases
Bgeei | ENSG00000183087, Expressed in thoracic aorta and 235 other tissues |
Genevisiblei | Q14393, HS |
Organism-specific databases
HPAi | ENSG00000183087, Low tissue specificity |
Interactioni
Subunit structurei
Heterodimer and heterotetramer with AXL.
1 PublicationBinary interactionsi
Isoform 2 [Q14393-1]
With | #Exp. | IntAct |
---|---|---|
AXL [P30530] | 8 | EBI-20753849,EBI-2850927 |
GO - Molecular functioni
- receptor ligand activity Source: MGI
- receptor tyrosine kinase binding Source: UniProtKB
- signaling receptor binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 108891, 36 interactors |
IntActi | Q14393, 34 interactors |
MINTi | Q14393 |
STRINGi | 9606.ENSP00000331831 |
Miscellaneous databases
RNActi | Q14393, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q14393 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q14393 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 53 – 94 | GlaPROSITE-ProRule annotationAdd BLAST | 42 | |
Domaini | 116 – 154 | EGF-like 1; calcium-bindingPROSITE-ProRule annotationAdd BLAST | 39 | |
Domaini | 156 – 196 | EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd BLAST | 41 | |
Domaini | 197 – 237 | EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd BLAST | 41 | |
Domaini | 238 – 278 | EGF-like 4; calcium-bindingPROSITE-ProRule annotationAdd BLAST | 41 | |
Domaini | 298 – 470 | Laminin G-like 1PROSITE-ProRule annotationAdd BLAST | 173 | |
Domaini | 477 – 670 | Laminin G-like 2PROSITE-ProRule annotationAdd BLAST | 194 |
Keywords - Domaini
EGF-like domain, Repeat, SignalPhylogenomic databases
eggNOGi | ENOG502QT2N, Eukaryota |
GeneTreei | ENSGT00940000161271 |
HOGENOMi | CLU_026236_0_0_1 |
InParanoidi | Q14393 |
OMAi | VGTETTW |
OrthoDBi | 317733at2759 |
PhylomeDBi | Q14393 |
TreeFami | TF352157 |
Family and domain databases
Gene3Di | 4.10.740.10, 1 hit |
InterProi | View protein in InterPro IPR026823, cEGF IPR017857, Coagulation_fac-like_Gla_dom IPR013320, ConA-like_dom_sf IPR001881, EGF-like_Ca-bd_dom IPR013032, EGF-like_CS IPR000742, EGF-like_dom IPR000152, EGF-type_Asp/Asn_hydroxyl_site IPR018097, EGF_Ca-bd_CS IPR035972, GLA-like_dom_SF IPR000294, GLA_domain IPR009030, Growth_fac_rcpt_cys_sf IPR001791, Laminin_G |
Pfami | View protein in Pfam PF12662, cEGF, 1 hit PF07645, EGF_CA, 1 hit PF00594, Gla, 1 hit PF12661, hEGF, 2 hits PF00054, Laminin_G_1, 1 hit PF02210, Laminin_G_2, 1 hit |
PRINTSi | PR00001, GLABLOOD |
SMARTi | View protein in SMART SM00181, EGF, 4 hits SM00179, EGF_CA, 4 hits SM00069, GLA, 1 hit SM00282, LamG, 2 hits |
SUPFAMi | SSF49899, SSF49899, 2 hits SSF57184, SSF57184, 1 hit SSF57630, SSF57630, 1 hit |
PROSITEi | View protein in PROSITE PS00010, ASX_HYDROXYL, 4 hits PS00022, EGF_1, 1 hit PS01186, EGF_2, 3 hits PS50026, EGF_3, 4 hits PS01187, EGF_CA, 3 hits PS00011, GLA_1, 1 hit PS50998, GLA_2, 1 hit PS50025, LAM_G_DOMAIN, 2 hits |
s (5)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 5 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q14393-2) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAPSLSPGPA ALRRAPQLLL LLLAAECALA ALLPAREATQ FLRPRQRRAF
60 70 80 90 100
QVFEEAKQGH LERECVEELC SREEAREVFE NDPETDYFYP RYLDCINKYG
110 120 130 140 150
SPYTKNSGFA TCVQNLPDQC TPNPCDRKGT QACQDLMGNF FCLCKAGWGG
160 170 180 190 200
RLCDKDVNEC SQENGGCLQI CHNKPGSFHC SCHSGFELSS DGRTCQDIDE
210 220 230 240 250
CADSEACGEA RCKNLPGSYS CLCDEGFAYS SQEKACRDVD ECLQGRCEQV
260 270 280 290 300
CVNSPGSYTC HCDGRGGLKL SQDMDTCEDI LPCVPFSVAK SVKSLYLGRM
310 320 330 340 350
FSGTPVIRLR FKRLQPTRLV AEFDFRTFDP EGILLFAGGH QDSTWIVLAL
360 370 380 390 400
RAGRLELQLR YNGVGRVTSS GPVINHGMWQ TISVEELARN LVIKVNRDAV
410 420 430 440 450
MKIAVAGDLF QPERGLYHLN LTVGGIPFHE KDLVQPINPR LDGCMRSWNW
460 470 480 490 500
LNGEDTTIQE TVKVNTRMQC FSVTERGSFY PGSGFAFYSL DYMRTPLDVG
510 520 530 540 550
TESTWEVEVV AHIRPAADTG VLFALWAPDL RAVPLSVALV DYHSTKKLKK
560 570 580 590 600
QLVVLAVEHT ALALMEIKVC DGQEHVVTVS LRDGEATLEV DGTRGQSEVS
610 620 630 640 650
AAQLQERLAV LERHLRSPVL TFAGGLPDVP VTSAPVTAFY RGCMTLEVNR
660 670
RLLDLDEAAY KHSDITAHSC PPVEPAAA
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 356 | E → K in BAG52469 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_038823 | 41 | F → L1 PublicationCorresponds to variant dbSNP:rs201378406Ensembl. | 1 | |
Natural variantiVAR_038824 | 231 | S → Y1 PublicationCorresponds to variant dbSNP:rs146159446Ensembl. | 1 | |
Natural variantiVAR_038825 | 347 | V → M1 PublicationCorresponds to variant dbSNP:rs144457857Ensembl. | 1 | |
Natural variantiVAR_038826 | 500 | G → R1 PublicationCorresponds to variant dbSNP:rs7992146EnsemblClinVar. | 1 | |
Natural variantiVAR_038827 | 580 | S → L1 PublicationCorresponds to variant dbSNP:rs79807310EnsemblClinVar. | 1 | |
Natural variantiVAR_038828 | 612 | E → K1 PublicationCorresponds to variant dbSNP:rs73583241EnsemblClinVar. | 1 | |
Natural variantiVAR_038829 | 616 | R → Q1 PublicationCorresponds to variant dbSNP:rs199700915EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_059767 | 1 – 299 | Missing in isoform 5. Add BLAST | 299 | |
Alternative sequenceiVSP_059768 | 1 – 273 | Missing in isoform 4. Add BLAST | 273 | |
Alternative sequenceiVSP_059769 | 1 – 94 | MAPSL…PRYLD → MCMCQASPPPAALAGCLLSS CVQPAREHGGAFSKAEWLSN in isoform 3. Add BLAST | 94 | |
Alternative sequenceiVSP_059770 | 278 | E → ELEAGWPCPRHRRDGSPAAR PGRGAQGSRSEGHIPDRRGP RPWQ in isoform 2. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L13720 mRNA Translation: AAA58494.1 AY256843 , AY256830, AY256831, AY256832, AY256833, AY256834, AY256835, AY256836, AY256837, AY256838, AY256839, AY256840, AY256841, AY256842 Genomic DNA Translation: AAO84057.1 AK092028 mRNA Translation: BAG52469.1 AK122969 mRNA Translation: BAG53826.1 AK126533 mRNA Translation: BAC86580.1 AK290803 mRNA Translation: BAF83492.1 EF631974 Genomic DNA Translation: ABR09277.1 BX072579 Genomic DNA No translation available. BC038984 mRNA Translation: AAH38984.1 AY170372 Genomic DNA Translation: AAO41859.1 BK001240 Genomic DNA Translation: DAA01155.1 |
CCDSi | CCDS45072.1 [Q14393-2] |
PIRi | B48089 |
RefSeqi | NP_000811.1, NM_000820.3 [Q14393-2] |
Genome annotation databases
Ensembli | ENST00000327773; ENSP00000331831; ENSG00000183087 [Q14393-2] |
GeneIDi | 2621 |
KEGGi | hsa:2621 |
UCSCi | uc001vud.4, human [Q14393-2] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
SeattleSNPs |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L13720 mRNA Translation: AAA58494.1 AY256843 , AY256830, AY256831, AY256832, AY256833, AY256834, AY256835, AY256836, AY256837, AY256838, AY256839, AY256840, AY256841, AY256842 Genomic DNA Translation: AAO84057.1 AK092028 mRNA Translation: BAG52469.1 AK122969 mRNA Translation: BAG53826.1 AK126533 mRNA Translation: BAC86580.1 AK290803 mRNA Translation: BAF83492.1 EF631974 Genomic DNA Translation: ABR09277.1 BX072579 Genomic DNA No translation available. BC038984 mRNA Translation: AAH38984.1 AY170372 Genomic DNA Translation: AAO41859.1 BK001240 Genomic DNA Translation: DAA01155.1 |
CCDSi | CCDS45072.1 [Q14393-2] |
PIRi | B48089 |
RefSeqi | NP_000811.1, NM_000820.3 [Q14393-2] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1H30 | X-ray | 2.20 | A | 261-678 | [»] | |
2C5D | X-ray | 3.30 | A/B | 261-678 | [»] | |
4RA0 | X-ray | 3.07 | A/B | 279-678 | [»] | |
5VXZ | X-ray | 2.30 | A/B | 281-675 | [»] | |
SMRi | Q14393 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 108891, 36 interactors |
IntActi | Q14393, 34 interactors |
MINTi | Q14393 |
STRINGi | 9606.ENSP00000331831 |
PTM databases
GlyGeni | Q14393, 1 site |
iPTMneti | Q14393 |
PhosphoSitePlusi | Q14393 |
Genetic variation databases
BioMutai | GAS6 |
DMDMi | 48427995 |
Proteomic databases
EPDi | Q14393 |
jPOSTi | Q14393 |
MassIVEi | Q14393 |
MaxQBi | Q14393 |
PeptideAtlasi | Q14393 |
PRIDEi | Q14393 |
ProteomicsDBi | 19251 59975 [Q14393-1] 59976 [Q14393-2] 59977 [Q14393-3] 59978 [Q14393-4] |
Protocols and materials databases
Antibodypediai | 1292, 395 antibodies |
Genome annotation databases
Ensembli | ENST00000327773; ENSP00000331831; ENSG00000183087 [Q14393-2] |
GeneIDi | 2621 |
KEGGi | hsa:2621 |
UCSCi | uc001vud.4, human [Q14393-2] |
Organism-specific databases
CTDi | 2621 |
DisGeNETi | 2621 |
GeneCardsi | GAS6 |
HGNCi | HGNC:4168, GAS6 |
HPAi | ENSG00000183087, Low tissue specificity |
MIMi | 600441, gene |
neXtProti | NX_Q14393 |
OpenTargetsi | ENSG00000183087 |
PharmGKBi | PA28582 |
VEuPathDBi | HostDB:ENSG00000183087.14 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QT2N, Eukaryota |
GeneTreei | ENSGT00940000161271 |
HOGENOMi | CLU_026236_0_0_1 |
InParanoidi | Q14393 |
OMAi | VGTETTW |
OrthoDBi | 317733at2759 |
PhylomeDBi | Q14393 |
TreeFami | TF352157 |
Enzyme and pathway databases
PathwayCommonsi | Q14393 |
Reactomei | R-HSA-114608, Platelet degranulation R-HSA-159740, Gamma-carboxylation of protein precursors R-HSA-159763, Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus R-HSA-159782, Removal of aminoterminal propeptides from gamma-carboxylated proteins R-HSA-202733, Cell surface interactions at the vascular wall R-HSA-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-8957275, Post-translational protein phosphorylation |
SignaLinki | Q14393 |
SIGNORi | Q14393 |
Miscellaneous databases
BioGRID-ORCSi | 2621, 7 hits in 998 CRISPR screens |
ChiTaRSi | GAS6, human |
EvolutionaryTracei | Q14393 |
GeneWikii | GAS6 |
GenomeRNAii | 2621 |
Pharosi | Q14393, Tbio |
PROi | PR:Q14393 |
RNActi | Q14393, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000183087, Expressed in thoracic aorta and 235 other tissues |
Genevisiblei | Q14393, HS |
Family and domain databases
Gene3Di | 4.10.740.10, 1 hit |
InterProi | View protein in InterPro IPR026823, cEGF IPR017857, Coagulation_fac-like_Gla_dom IPR013320, ConA-like_dom_sf IPR001881, EGF-like_Ca-bd_dom IPR013032, EGF-like_CS IPR000742, EGF-like_dom IPR000152, EGF-type_Asp/Asn_hydroxyl_site IPR018097, EGF_Ca-bd_CS IPR035972, GLA-like_dom_SF IPR000294, GLA_domain IPR009030, Growth_fac_rcpt_cys_sf IPR001791, Laminin_G |
Pfami | View protein in Pfam PF12662, cEGF, 1 hit PF07645, EGF_CA, 1 hit PF00594, Gla, 1 hit PF12661, hEGF, 2 hits PF00054, Laminin_G_1, 1 hit PF02210, Laminin_G_2, 1 hit |
PRINTSi | PR00001, GLABLOOD |
SMARTi | View protein in SMART SM00181, EGF, 4 hits SM00179, EGF_CA, 4 hits SM00069, GLA, 1 hit SM00282, LamG, 2 hits |
SUPFAMi | SSF49899, SSF49899, 2 hits SSF57184, SSF57184, 1 hit SSF57630, SSF57630, 1 hit |
PROSITEi | View protein in PROSITE PS00010, ASX_HYDROXYL, 4 hits PS00022, EGF_1, 1 hit PS01186, EGF_2, 3 hits PS50026, EGF_3, 4 hits PS01187, EGF_CA, 3 hits PS00011, GLA_1, 1 hit PS50998, GLA_2, 1 hit PS50025, LAM_G_DOMAIN, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GAS6_HUMAN | |
Accessioni | Q14393Primary (citable) accession number: Q14393 Secondary accession number(s): B3KRQ7 Q7Z7N3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 7, 2004 |
Last sequence update: | September 12, 2018 | |
Last modified: | April 7, 2021 | |
This is version 210 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 13
Human chromosome 13: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references