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UniProtKB - Q14392 (LRC32_HUMAN)

Entry version 171 (02 Dec 2020)
Sequence version 1 (01 Nov 1996)
Previous versions | rss
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Protein

Transforming growth factor beta activator LRRC32

Gene

LRRC32

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space (PubMed:19750484, PubMed:19651619, PubMed:22278742). Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta (PubMed:22278742). Able to outcompete LTBP1 for binding to LAP regulatory chain of TGF-beta (PubMed:22278742). Controls activation of TGF-beta-1 (TGFB1) on the surface of activated regulatory T-cells (Tregs) (PubMed:19750484, PubMed:19651619). Required for epithelial fusion during palate development by regulating activation of TGF-beta-3 (TGFB3) (By similarity).By similarity3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGrowth factor binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q14392

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transforming growth factor beta activator LRRC32Curated
Alternative name(s):
Garpin1 Publication
Glycoprotein A repetitions predominant2 Publications
Short name:
GARP2 Publications
Leucine-rich repeat-containing protein 321 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LRRC321 PublicationImported
Synonyms:D11S833E
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000137507.11

Human Gene Nomenclature Database

More...HGNCi		HGNC:4161, LRRC32

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		137207, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q14392

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini20 – 627ExtracellularSequence analysisAdd BLAST608
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei628 – 648HelicalSequence analysisAdd BLAST21
Topological domaini649 – 662CytoplasmicSequence analysisAdd BLAST14

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi211C → A: Abolishes interaction with Latency-associated peptide (LAP) of TGFB1; when associated with A-350. 1 Publication1
Mutagenesisi350C → A: Abolishes interaction with Latency-associated peptide (LAP) of TGFB1; when associated with A-211. 1 Publication1
Mutagenesisi436C → A: Abolishes Cell surface localization without affecting interaction with Latency-associated peptide (LAP) of TGFB1. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		2615

Open Targets

More...OpenTargetsi		ENSG00000137507

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA28574

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q14392, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		LRRC32

Domain mapping of disease mutations (DMDM)

More...DMDMi		2498405

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 191 PublicationAdd BLAST19
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002161520 – 662Transforming growth factor beta activator LRRC32Add BLAST643

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi203N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi211Interchain (with C-33 in TGFB1); in linked form1 Publication
Glycosylationi271N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi308N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi345N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi350Interchain (with C-33 in TGFB1); in linked form1 Publication
Glycosylationi545N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q14392

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q14392

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q14392

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q14392

PeptideAtlas

More...PeptideAtlasi		Q14392

PRoteomics IDEntifications database

More...PRIDEi		Q14392

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		59974

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q14392, 5 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q14392

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q14392

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q14392

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Preferentially expressed in regulatory T-cells (Tregs).3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000137507, Expressed in left coronary artery and 172 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q14392, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q14392, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000137507, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with TGFB1; associates via disulfide bonds with the Latency-associated peptide chain (LAP) regulatory chain of TGFB1, leading to regulate activation of TGF-beta-1 (PubMed:19651619, PubMed:22278742).

Interacts with TGFB2 (PubMed:19651619).

Interacts with TGFB3; associates via disulfide bonds with the Latency-associated peptide chain (LAP) regulatory chain of TGFB3, leading to regulate activation of TGF-beta-3 (By similarity).

Interacts with LAPTM4B; decreases TGFB1 production in regulatory T-cells (PubMed:26126825).

By similarity3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		108885, 13 interactors

Database of interacting proteins

More...DIPi		DIP-48932N

Protein interaction database and analysis system

More...IntActi		Q14392, 10 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000384126

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q14392, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1662
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q14392

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini21 – 48LRRNTSequence analysisAdd BLAST28
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati50 – 73LRR 1Sequence analysisAdd BLAST24
Repeati74 – 95LRR 2Sequence analysisAdd BLAST22
Repeati98 – 119LRR 3Sequence analysisAdd BLAST22
Repeati125 – 145LRR 4Sequence analysisAdd BLAST21
Repeati150 – 171LRR 5Sequence analysisAdd BLAST22
Repeati174 – 195LRR 6Sequence analysisAdd BLAST22
Repeati198 – 219LRR 7Sequence analysisAdd BLAST22
Repeati220 – 240LRR 8Sequence analysisAdd BLAST21
Repeati244 – 265LRR 9Sequence analysisAdd BLAST22
Repeati266 – 286LRR 10Sequence analysisAdd BLAST21
Repeati316 – 339LRR 11Sequence analysisAdd BLAST24
Repeati340 – 363LRR 12Sequence analysisAdd BLAST24
Repeati364 – 385LRR 13Sequence analysisAdd BLAST22
Repeati387 – 408LRR 14Sequence analysisAdd BLAST22
Repeati411 – 432LRR 15Sequence analysisAdd BLAST22
Repeati444 – 465LRR 16Sequence analysisAdd BLAST22
Repeati467 – 488LRR 17Sequence analysisAdd BLAST22
Repeati492 – 513LRR 18Sequence analysisAdd BLAST22
Repeati515 – 536LRR 19Sequence analysisAdd BLAST22
Repeati537 – 558LRR 20Sequence analysisAdd BLAST22
Domaini571 – 620LRRCTSequence analysisAdd BLAST50

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the LRRC32/LRRC33 family.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0619, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000162288

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_024194_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q14392

Identification of Orthologs from Complete Genome Data

More...OMAi		DIETVTC

Database of Orthologous Groups

More...OrthoDBi		826997at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q14392

TreeFam database of animal gene trees

More...TreeFami		TF317167

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.80.10.10, 4 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001611, Leu-rich_rpt
IPR003591, Leu-rich_rpt_typical-subtyp
IPR032675, LRR_dom_sf
IPR000372, LRRNT

Pfam protein domain database

More...Pfami		View protein in Pfam
PF13855, LRR_8, 5 hits
PF01462, LRRNT, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00369, LRR_TYP, 14 hits
SM00013, LRRNT, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51450, LRR, 20 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q14392-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRPQILLLLA LLTLGLAAQH QDKVPCKMVD KKVSCQVLGL LQVPSVLPPD 
        60         70         80         90        100
TETLDLSGNQ LRSILASPLG FYTALRHLDL STNEISFLQP GAFQALTHLE 
       110        120        130        140        150
HLSLAHNRLA MATALSAGGL GPLPRVTSLD LSGNSLYSGL LERLLGEAPS 
       160        170        180        190        200
LHTLSLAENS LTRLTRHTFR DMPALEQLDL HSNVLMDIED GAFEGLPRLT 
       210        220        230        240        250
HLNLSRNSLT CISDFSLQQL RVLDLSCNSI EAFQTASQPQ AEFQLTWLDL 
       260        270        280        290        300
RENKLLHFPD LAALPRLIYL NLSNNLIRLP TGPPQDSKGI HAPSEGWSAL 
       310        320        330        340        350
PLSAPSGNAS GRPLSQLLNL DLSYNEIELI PDSFLEHLTS LCFLNLSRNC 
       360        370        380        390        400
LRTFEARRLG SLPCLMLLDL SHNALETLEL GARALGSLRT LLLQGNALRD 
       410        420        430        440        450
LPPYTFANLA SLQRLNLQGN RVSPCGGPDE PGPSGCVAFS GITSLRSLSL 
       460        470        480        490        500
VDNEIELLRA GAFLHTPLTE LDLSSNPGLE VATGALGGLE ASLEVLALQG 
       510        520        530        540        550
NGLMVLQVDL PCFICLKRLN LAENRLSHLP AWTQAVSLEV LDLRNNSFSL 
       560        570        580        590        600
LPGSAMGGLE TSLRRLYLQG NPLSCCGNGW LAAQLHQGRV DVDATQDLIC 
       610        620        630        640        650
RFSSQEEVSL SHVRPEDCEK GGLKNINLII ILTFILVSAI LLTTLAACCC 
       660 
VRRQKFNQQY KA
Length:662
Mass (Da):71,979
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i700B93ADCDF25960
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JYU3C9JYU3_HUMAN
Transforming growth factor beta act...
LRRC32
186Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH52210 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_051113223L → V. Corresponds to variant dbSNP:rs35033061Ensembl.1
Natural variantiVAR_051114311G → A. Corresponds to variant dbSNP:rs35130967Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
Z24680 mRNA Translation: CAA80847.1
BC052210 mRNA Translation: AAH52210.2 Different initiation.
BC070079 mRNA Translation: AAH70079.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS8245.1

Protein sequence database of the Protein Information Resource

More...PIRi		S42799

NCBI Reference Sequences

More...RefSeqi		NP_001122394.1, NM_001128922.1
NP_005503.1, NM_005512.2
XP_005273959.1, XM_005273902.3
XP_011543237.1, XM_011544935.2
XP_016873016.1, XM_017017527.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000260061; ENSP00000260061; ENSG00000137507
ENST00000404995; ENSP00000385766; ENSG00000137507
ENST00000407242; ENSP00000384126; ENSG00000137507

Database of genes from NCBI RefSeq genomes

More...GeneIDi		2615

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:2615

UCSC genome browser

More...UCSCi		uc001oxq.5, human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z24680 mRNA Translation: CAA80847.1
BC052210 mRNA Translation: AAH52210.2 Different initiation.
BC070079 mRNA Translation: AAH70079.1
CCDSiCCDS8245.1
PIRiS42799
RefSeqiNP_001122394.1, NM_001128922.1
NP_005503.1, NM_005512.2
XP_005273959.1, XM_005273902.3
XP_011543237.1, XM_011544935.2
XP_016873016.1, XM_017017527.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6GFFX-ray3.10I/J20-628[»]
SMRiQ14392
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi108885, 13 interactors
DIPiDIP-48932N
IntActiQ14392, 10 interactors
STRINGi9606.ENSP00000384126

PTM databases

GlyGeniQ14392, 5 sites
iPTMnetiQ14392
PhosphoSitePlusiQ14392
SwissPalmiQ14392

Polymorphism and mutation databases

BioMutaiLRRC32
DMDMi2498405

Proteomic databases

jPOSTiQ14392
MassIVEiQ14392
MaxQBiQ14392
PaxDbiQ14392
PeptideAtlasiQ14392
PRIDEiQ14392
ProteomicsDBi59974

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		45130, 309 antibodies

Genome annotation databases

EnsembliENST00000260061; ENSP00000260061; ENSG00000137507
ENST00000404995; ENSP00000385766; ENSG00000137507
ENST00000407242; ENSP00000384126; ENSG00000137507
GeneIDi2615
KEGGihsa:2615
UCSCiuc001oxq.5, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		2615
DisGeNETi2615
EuPathDBiHostDB:ENSG00000137507.11

GeneCards: human genes, protein and diseases

More...GeneCardsi		LRRC32
HGNCiHGNC:4161, LRRC32
HPAiENSG00000137507, Low tissue specificity
MIMi137207, gene
neXtProtiNX_Q14392
OpenTargetsiENSG00000137507
PharmGKBiPA28574

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0619, Eukaryota
GeneTreeiENSGT00940000162288
HOGENOMiCLU_024194_1_0_1
InParanoidiQ14392
OMAiDIETVTC
OrthoDBi826997at2759
PhylomeDBiQ14392
TreeFamiTF317167

Enzyme and pathway databases

PathwayCommonsiQ14392

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		2615, 8 hits in 841 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		LRRC32, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		2615
PharosiQ14392, Tbio

Protein Ontology

More...PROi		PR:Q14392
RNActiQ14392, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000137507, Expressed in left coronary artery and 172 other tissues
ExpressionAtlasiQ14392, baseline and differential
GenevisibleiQ14392, HS

Family and domain databases

Gene3Di3.80.10.10, 4 hits
InterProiView protein in InterPro
IPR001611, Leu-rich_rpt
IPR003591, Leu-rich_rpt_typical-subtyp
IPR032675, LRR_dom_sf
IPR000372, LRRNT
PfamiView protein in Pfam
PF13855, LRR_8, 5 hits
PF01462, LRRNT, 1 hit
SMARTiView protein in SMART
SM00369, LRR_TYP, 14 hits
SM00013, LRRNT, 1 hit
PROSITEiView protein in PROSITE
PS51450, LRR, 20 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLRC32_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q14392
Secondary accession number(s): Q86V06
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: December 2, 2020
This is version 171 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
  5. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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