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Protein

Myosin-binding protein C, fast-type

Gene

MYBPC2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role.

GO - Molecular functioni

  • actin filament binding Source: GO_Central
  • muscle alpha-actinin binding Source: GO_Central
  • structural constituent of muscle Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionActin-binding, Muscle protein
Biological processCell adhesion

Enzyme and pathway databases

ReactomeiR-HSA-390522 Striated Muscle Contraction

Names & Taxonomyi

Protein namesi
Recommended name:
Myosin-binding protein C, fast-type
Short name:
Fast MyBP-C
Alternative name(s):
C-protein, skeletal muscle fast isoform
Gene namesi
Name:MYBPC2
Synonyms:MYBPCF
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000086967.9
HGNCiHGNC:7550 MYBPC2
MIMi160793 gene
neXtProtiNX_Q14324

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Thick filament

Pathology & Biotechi

Organism-specific databases

DisGeNETi4606
OpenTargetsiENSG00000086967
PharmGKBiPA31350

Polymorphism and mutation databases

BioMutaiMYBPC2
DMDMi296439237

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000726911 – 1141Myosin-binding protein C, fast-typeAdd BLAST1141

Proteomic databases

EPDiQ14324
PaxDbiQ14324
PeptideAtlasiQ14324
PRIDEiQ14324
ProteomicsDBi59965

2D gel databases

REPRODUCTION-2DPAGEiIPI00030104

PTM databases

CarbonylDBiQ14324
iPTMnetiQ14324
PhosphoSitePlusiQ14324

Expressioni

Gene expression databases

BgeeiENSG00000086967 Expressed in 109 organ(s), highest expression level in biceps brachii
CleanExiHS_MYBPC2
ExpressionAtlasiQ14324 baseline and differential
GenevisibleiQ14324 HS

Organism-specific databases

HPAiHPA042991
HPA046745

Interactioni

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi110691, 2 interactors
IntActiQ14324, 30 interactors
MINTiQ14324
STRINGi9606.ENSP00000350332

Structurei

Secondary structure

11141
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ14324
SMRiQ14324
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ14324

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini50 – 153Ig-like C2-type 1Add BLAST104
Domaini255 – 344Ig-like C2-type 2Add BLAST90
Domaini345 – 437Ig-like C2-type 3Add BLAST93
Domaini438 – 538Ig-like C2-type 4Add BLAST101
Domaini539 – 638Ig-like C2-type 5Add BLAST100
Domaini641 – 737Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST97
Domaini739 – 834Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST96
Domaini838 – 932Ig-like C2-type 6Add BLAST95
Domaini935 – 1030Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST96
Domaini1048 – 1141Ig-like C2-type 7Add BLAST94

Sequence similaritiesi

Belongs to the immunoglobulin superfamily. MyBP family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat

Phylogenomic databases

eggNOGiENOG410IFCI Eukaryota
ENOG4110AYI LUCA
GeneTreeiENSGT00860000133685
HOGENOMiHOG000220906
HOVERGENiHBG052560
InParanoidiQ14324
KOiK12558
OMAiKEHDFRT
OrthoDBiEOG091G00ND
PhylomeDBiQ14324
TreeFamiTF351819

Family and domain databases

CDDicd00063 FN3, 3 hits
Gene3Di2.60.40.10, 10 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
PfamiView protein in Pfam
PF00041 fn3, 3 hits
PF07679 I-set, 7 hits
SMARTiView protein in SMART
SM00060 FN3, 3 hits
SM00409 IG, 7 hits
SM00408 IGc2, 4 hits
SUPFAMiSSF48726 SSF48726, 7 hits
SSF49265 SSF49265, 2 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 3 hits
PS50835 IG_LIKE, 5 hits

Sequencei

Sequence statusi: Complete.

Q14324-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPEAKPAAKK APKGKDAPKG APKEAPPKEA PAEAPKEAPP EDQSPTAEEP
60 70 80 90 100
TGVFLKKPDS VSVETGKDAV VVAKVNGKEL PDKPTIKWFK GKWLELGSKS
110 120 130 140 150
GARFSFKESH NSASNVYTVE LHIGKVVLGD RGYYRLEVKA KDTCDSCGFN
160 170 180 190 200
IDVEAPRQDA SGQSLESFKR TSEKKSDTAG ELDFSGLLKK REVVEEEKKK
210 220 230 240 250
KKKDDDDLGI PPEIWELLKG AKKSEYEKIA FQYGITDLRG MLKRLKKAKV
260 270 280 290 300
EVKKSAAFTK KLDPAYQVDR GNKIKLMVEI SDPDLTLKWF KNGQEIKPSS
310 320 330 340 350
KYVFENVGKK RILTINKCTL ADDAAYEVAV KDEKCFTELF VKEPPVLIVT
360 370 380 390 400
PLEDQQVFVG DRVEMAVEVS EEGAQVMWMK DGVELTREDS FKARYRFKKD
410 420 430 440 450
GKRHILIFSD VVQEDRGRYQ VITNGGQCEA ELIVEEKQLE VLQDIADLTV
460 470 480 490 500
KASEQAVFKC EVSDEKVTGK WYKNGVEVRP SKRITISHVG RFHKLVIDDV
510 520 530 540 550
RPEDEGDYTF VPDGYALSLS AKLNFLEIKV EYVPKQEPPK IHLDCSGKTS
560 570 580 590 600
ENAIVVVAGN KLRLDVSITG EPPPVATWLK GDEVFTTTEG RTRIEKRVDC
610 620 630 640 650
SSFVIESAQR EDEGRYTIKV TNPVGEDVAS IFLQVVDVPD PPEAVRITSV
660 670 680 690 700
GEDWAILVWE PPMYDGGKPV TGYLVERKKK GSQRWMKLNF EVFTETTYES
710 720 730 740 750
TKMIEGILYE MRVFAVNAIG VSQPSMNTKP FMPIAPTSEP LHLIVEDVTD
760 770 780 790 800
TTTTLKWRPP NRIGAGGIDG YLVEYCLEGS EEWVPANTEP VERCGFTVKN
810 820 830 840 850
LPTGARILFR VVGVNIAGRS EPATLAQPVT IREIAEPPKI RLPRHLRQTY
860 870 880 890 900
IRKVGEQLNL VVPFQGKPRP QVVWTKGGAP LDTSRVHVRT SDFDTVFFVR
910 920 930 940 950
QAARSDSGEY ELSVQIENMK DTATIRIRVV EKAGPPINVM VKEVWGTNAL
960 970 980 990 1000
VEWQAPKDDG NSEIMGYFVQ KADKKTMEWF NVYERNRHTS CTVSDLIVGN
1010 1020 1030 1040 1050
EYYFRVYTEN ICGLSDSPGV SKNTARILKT GITFKPFEYK EHDFRMAPKF
1060 1070 1080 1090 1100
LTPLIDRVVV AGYSAALNCA VRGHPKPKVV WMKNKMEIRE DPKFLITNYQ
1110 1120 1130 1140
GVLTLNIRRP SPFDAGTYTC RAVNELGEAL AECKLEVRVP Q
Length:1,141
Mass (Da):128,072
Last modified:May 18, 2010 - v2
Checksum:i91F4B18C4367743A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti517L → LG in CAA51544 (PubMed:8375400).Curated1
Sequence conflicti820S → T in CAA51544 (PubMed:8375400).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06132129E → K. Corresponds to variant dbSNP:rs57092106Ensembl.1
Natural variantiVAR_01465752G → S. Corresponds to variant dbSNP:rs25669Ensembl.1
Natural variantiVAR_056060282D → N. Corresponds to variant dbSNP:rs35951152Ensembl.1
Natural variantiVAR_061322341V → I. Corresponds to variant dbSNP:rs58511181Ensembl.1
Natural variantiVAR_056061514G → S. Corresponds to variant dbSNP:rs8104931Ensembl.1
Natural variantiVAR_014658624V → I. Corresponds to variant dbSNP:rs25665Ensembl.1
Natural variantiVAR_0146591089R → H. Corresponds to variant dbSNP:rs25667Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X73113 mRNA Translation: CAA51544.1
AC020909 Genomic DNA No translation available.
CH471135 Genomic DNA Translation: EAW71866.1
BC130536 mRNA Translation: AAI30537.1
BC136389 mRNA Translation: AAI36390.1
CCDSiCCDS46152.1
PIRiS36845
RefSeqiNP_004524.3, NM_004533.3
UniGeneiHs.85937

Genome annotation databases

EnsembliENST00000357701; ENSP00000350332; ENSG00000086967
GeneIDi4606
KEGGihsa:4606
UCSCiuc002psf.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X73113 mRNA Translation: CAA51544.1
AC020909 Genomic DNA No translation available.
CH471135 Genomic DNA Translation: EAW71866.1
BC130536 mRNA Translation: AAI30537.1
BC136389 mRNA Translation: AAI36390.1
CCDSiCCDS46152.1
PIRiS36845
RefSeqiNP_004524.3, NM_004533.3
UniGeneiHs.85937

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2E7CNMR-A824-934[»]
2EDKNMR-A345-438[»]
2EDNNMR-A47-157[»]
ProteinModelPortaliQ14324
SMRiQ14324
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110691, 2 interactors
IntActiQ14324, 30 interactors
MINTiQ14324
STRINGi9606.ENSP00000350332

PTM databases

CarbonylDBiQ14324
iPTMnetiQ14324
PhosphoSitePlusiQ14324

Polymorphism and mutation databases

BioMutaiMYBPC2
DMDMi296439237

2D gel databases

REPRODUCTION-2DPAGEiIPI00030104

Proteomic databases

EPDiQ14324
PaxDbiQ14324
PeptideAtlasiQ14324
PRIDEiQ14324
ProteomicsDBi59965

Protocols and materials databases

DNASUi4606
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000357701; ENSP00000350332; ENSG00000086967
GeneIDi4606
KEGGihsa:4606
UCSCiuc002psf.3 human

Organism-specific databases

CTDi4606
DisGeNETi4606
EuPathDBiHostDB:ENSG00000086967.9
GeneCardsiMYBPC2
H-InvDBiHIX0040195
HGNCiHGNC:7550 MYBPC2
HPAiHPA042991
HPA046745
MIMi160793 gene
neXtProtiNX_Q14324
OpenTargetsiENSG00000086967
PharmGKBiPA31350
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFCI Eukaryota
ENOG4110AYI LUCA
GeneTreeiENSGT00860000133685
HOGENOMiHOG000220906
HOVERGENiHBG052560
InParanoidiQ14324
KOiK12558
OMAiKEHDFRT
OrthoDBiEOG091G00ND
PhylomeDBiQ14324
TreeFamiTF351819

Enzyme and pathway databases

ReactomeiR-HSA-390522 Striated Muscle Contraction

Miscellaneous databases

ChiTaRSiMYBPC2 human
EvolutionaryTraceiQ14324
GenomeRNAii4606
PROiPR:Q14324
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000086967 Expressed in 109 organ(s), highest expression level in biceps brachii
CleanExiHS_MYBPC2
ExpressionAtlasiQ14324 baseline and differential
GenevisibleiQ14324 HS

Family and domain databases

CDDicd00063 FN3, 3 hits
Gene3Di2.60.40.10, 10 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
PfamiView protein in Pfam
PF00041 fn3, 3 hits
PF07679 I-set, 7 hits
SMARTiView protein in SMART
SM00060 FN3, 3 hits
SM00409 IG, 7 hits
SM00408 IGc2, 4 hits
SUPFAMiSSF48726 SSF48726, 7 hits
SSF49265 SSF49265, 2 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 3 hits
PS50835 IG_LIKE, 5 hits
ProtoNetiSearch...

Entry informationi

Entry nameiMYPC2_HUMAN
AccessioniPrimary (citable) accession number: Q14324
Secondary accession number(s): A1L4G9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: May 18, 2010
Last modified: November 7, 2018
This is version 167 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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