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UniProtKB - Q14296 (FASTK_HUMAN)

Entry version 177 (23 Feb 2022)
Sequence version 1 (01 Nov 1996)
Previous versions | rss
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Protein

Fas-activated serine/threonine kinase

Gene

FASTK

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Phosphorylates the splicing regulator TIA1, thereby promoting the inclusion of FAS exon 6, which leads to an mRNA encoding a pro-apoptotic form of the receptor.

2 Publications

Required for the biogenesis of some mitochondrial-encoded mRNAs, specifically stabilizes ND6 (NADH dehydrogenase complex subunit 6) mRNA, and regulates its levels.

1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, RNA-binding, Serine/threonine-protein kinase, Transferase
Biological processApoptosis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		2.7.11.8, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q14296

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q14296

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Fas-activated serine/threonine kinase (EC:2.7.11.11 Publication, EC:2.7.11.81 Publication)
Short name:
FAST kinase
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FASTK
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:24676, FASTK

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		606965, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q14296

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000164896

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Mitochondrion

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi35M → G: Abolishes isoform 4 expression. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		10922

Open Targets

More...OpenTargetsi		ENSG00000164896

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA142671775

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q14296, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		FASTK

Domain mapping of disease mutations (DMDM)

More...DMDMi		13124202

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000871961 – 549Fas-activated serine/threonine kinaseAdd BLAST549

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Autophosphorylated on serine/threonine residues. Activated by dephosphorylation.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q14296

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q14296

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q14296

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q14296

PeptideAtlas

More...PeptideAtlasi		Q14296

PRoteomics IDEntifications database

More...PRIDEi		Q14296

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		28667
59957 [Q14296-1]
59958 [Q14296-2]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q14296, 1 site, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q14296

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q14296

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000164896, Expressed in apex of heart and 237 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q14296, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q14296, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000164896, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with TIA1; the interactions leads to TIA1 phosphorylation (PubMed:7544399, PubMed:17135269).

Interacts with TIAR (PubMed:7544399, PubMed:17135269).

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		116126, 14 interactors

Protein interaction database and analysis system

More...IntActi		Q14296, 13 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000297532

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q14296, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini477 – 535RAPPROSITE-ProRule annotationAdd BLAST59

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 30DisorderedSequence analysisAdd BLAST30

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The RAP domain is essential for RNA-binding.1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the FAST protein kinase family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QXK7, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT01030000234607

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_046861_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q14296

Identification of Orthologs from Complete Genome Data

More...OMAi		KVRTHHY

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q14296

TreeFam database of animal gene trees

More...TreeFami		TF331796

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR013579, FAST_2
IPR010622, FAST_Leu-rich
IPR013584, RAP
IPR015715, Ser/Thr_kinase_FAST

The PANTHER Classification System

More...PANTHERi		PTHR21228:SF4, PTHR21228:SF4, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF06743, FAST_1, 1 hit
PF08368, FAST_2, 1 hit
PF08373, RAP, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00952, RAP, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51286, RAP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing and alternative initiation. AlignAdd to basket

This entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q14296-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRRPRGEPGP RAPRPTEGAT CAGPGESWSP SPNSMLRVLL SAQTSPARLS 
        60         70         80         90        100
GLLLIPPVQP CCLGPSKWGD RPVGGGPSAG PVQGLQRLLE QAKSPGELLR 
       110        120        130        140        150
WLGQNPSKVR AHHYSVALRR LGQLLGSRPR PPPVEQVTLQ DLSQLIIRNC 
       160        170        180        190        200
PSFDIHTIHV CLHLAVLLGF PSDGPLVCAL EQERRLRLPP KPPPPLQPLL 
       210        220        230        240        250
RGGQGLEAAL SCPRFLRYPR QHLISSLAEA RPEELTPHVM VLLAQHLARH 
       260        270        280        290        300
RLREPQLLEA IAHFLVVQET QLSSKVVQKL VLPFGRLNYL PLEQQFMPCL 
       310        320        330        340        350
ERILAREAGV APLATVNILM SLCQLRCLPF RALHFVFSPG FINYISGTPH 
       360        370        380        390        400
ALIVRRYLSL LDTAVELELP GYRGPRLPRR QQVPIFPQPL ITDRARCKYS 
       410        420        430        440        450
HKDIVAEGLR QLLGEEKYRQ DLTVPPGYCT DFLLCASSSG AVLPVRTQDP 
       460        470        480        490        500
FLPYPPRSCP QGQAASSATT RDPAQRVVLV LRERWHFCRD GRVLLGSRAL 
       510        520        530        540 
RERHLGLMGY QLLPLPFEEL ESQRGLPQLK SYLRQKLQAL GLRWGPEGG
Length:549
Mass (Da):61,104
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i76D38A211B37304A
GO
Isoform 2 (identifier: Q14296-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     28-28: W → C
     29-169: Missing.

Show »
Length:408
Mass (Da):45,852
Checksum:i7C5944F3AF49F335
GO
Isoform 3 (identifier: Q14296-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     202-228: Missing.

Show »
Length:522
Mass (Da):58,181
Checksum:i86826CD34032595F
GO
Isoform 4 (identifier: Q14296-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-34: Missing.

Show »
Length:515
Mass (Da):57,576
Checksum:i142C239FE54C31EF
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V1R6G3V1R6_HUMAN
Fas-activated serine/threonine kina...
FASTK
465Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAD93020 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_042200424V → L in a lung adenocarcinoma sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs758691941Ensembl.1
Natural variantiVAR_021970436A → V. Corresponds to variant dbSNP:rs2288648Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0582461 – 34Missing in isoform 4. 1 PublicationAdd BLAST34
Alternative sequenceiVSP_04274628W → C in isoform 2. 1 Publication1
Alternative sequenceiVSP_04274729 – 169Missing in isoform 2. 1 PublicationAdd BLAST141
Alternative sequenceiVSP_044811202 – 228Missing in isoform 3. 1 PublicationAdd BLAST27

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X86779 mRNA Translation: CAA60448.1
AK292232 mRNA Translation: BAF84921.1
AB209783 mRNA Translation: BAD93020.1 Different initiation.
AC010973 Genomic DNA No translation available.
CH471173 Genomic DNA Translation: EAW54039.1
CH471173 Genomic DNA Translation: EAW54043.1
BC011770 mRNA Translation: AAH11770.1
BC039026 mRNA Translation: AAH39026.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS59088.1 [Q14296-3]
CCDS5918.1 [Q14296-1]
CCDS5919.1 [Q14296-2]

Protein sequence database of the Protein Information Resource

More...PIRi		I37386

NCBI Reference Sequences

More...RefSeqi		NP_001245390.1, NM_001258461.1 [Q14296-3]
NP_006703.1, NM_006712.4 [Q14296-1]
NP_148936.2, NM_033015.3 [Q14296-2]
XP_005249989.1, XM_005249932.1 [Q14296-4]
XP_005249990.1, XM_005249933.3 [Q14296-4]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000297532; ENSP00000297532; ENSG00000164896
ENST00000353841; ENSP00000324817; ENSG00000164896 [Q14296-2]
ENST00000482571; ENSP00000418516; ENSG00000164896 [Q14296-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		10922

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:10922

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000297532.11; ENSP00000297532.6; NM_006712.5; NP_006703.1

UCSC genome browser

More...UCSCi		uc003wix.3, human [Q14296-1]

Keywords - Coding sequence diversityi

Alternative initiation, Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X86779 mRNA Translation: CAA60448.1
AK292232 mRNA Translation: BAF84921.1
AB209783 mRNA Translation: BAD93020.1 Different initiation.
AC010973 Genomic DNA No translation available.
CH471173 Genomic DNA Translation: EAW54039.1
CH471173 Genomic DNA Translation: EAW54043.1
BC011770 mRNA Translation: AAH11770.1
BC039026 mRNA Translation: AAH39026.1
CCDSiCCDS59088.1 [Q14296-3]
CCDS5918.1 [Q14296-1]
CCDS5919.1 [Q14296-2]
PIRiI37386
RefSeqiNP_001245390.1, NM_001258461.1 [Q14296-3]
NP_006703.1, NM_006712.4 [Q14296-1]
NP_148936.2, NM_033015.3 [Q14296-2]
XP_005249989.1, XM_005249932.1 [Q14296-4]
XP_005249990.1, XM_005249933.3 [Q14296-4]

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi116126, 14 interactors
IntActiQ14296, 13 interactors
STRINGi9606.ENSP00000297532

PTM databases

GlyGeniQ14296, 1 site, 1 O-linked glycan (1 site)
iPTMnetiQ14296
PhosphoSitePlusiQ14296

Genetic variation databases

BioMutaiFASTK
DMDMi13124202

Proteomic databases

jPOSTiQ14296
MassIVEiQ14296
MaxQBiQ14296
PaxDbiQ14296
PeptideAtlasiQ14296
PRIDEiQ14296
ProteomicsDBi28667
59957 [Q14296-1]
59958 [Q14296-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		32964, 288 antibodies from 25 providers

The DNASU plasmid repository

More...DNASUi		10922

Genome annotation databases

EnsembliENST00000297532; ENSP00000297532; ENSG00000164896
ENST00000353841; ENSP00000324817; ENSG00000164896 [Q14296-2]
ENST00000482571; ENSP00000418516; ENSG00000164896 [Q14296-3]
GeneIDi10922
KEGGihsa:10922
MANE-SelectiENST00000297532.11; ENSP00000297532.6; NM_006712.5; NP_006703.1
UCSCiuc003wix.3, human [Q14296-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		10922
DisGeNETi10922

GeneCards: human genes, protein and diseases

More...GeneCardsi		FASTK
HGNCiHGNC:24676, FASTK
HPAiENSG00000164896, Low tissue specificity
MIMi606965, gene
neXtProtiNX_Q14296
OpenTargetsiENSG00000164896
PharmGKBiPA142671775
VEuPathDBiHostDB:ENSG00000164896

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502QXK7, Eukaryota
GeneTreeiENSGT01030000234607
HOGENOMiCLU_046861_0_0_1
InParanoidiQ14296
OMAiKVRTHHY
PhylomeDBiQ14296
TreeFamiTF331796

Enzyme and pathway databases

BRENDAi2.7.11.8, 2681
PathwayCommonsiQ14296
SignaLinkiQ14296

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		10922, 15 hits in 1075 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		FASTK, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		FASTK

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		10922
PharosiQ14296, Tbio

Protein Ontology

More...PROi		PR:Q14296
RNActiQ14296, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000164896, Expressed in apex of heart and 237 other tissues
ExpressionAtlasiQ14296, baseline and differential
GenevisibleiQ14296, HS

Family and domain databases

InterProiView protein in InterPro
IPR013579, FAST_2
IPR010622, FAST_Leu-rich
IPR013584, RAP
IPR015715, Ser/Thr_kinase_FAST
PANTHERiPTHR21228:SF4, PTHR21228:SF4, 1 hit
PfamiView protein in Pfam
PF06743, FAST_1, 1 hit
PF08368, FAST_2, 1 hit
PF08373, RAP, 1 hit
SMARTiView protein in SMART
SM00952, RAP, 1 hit
PROSITEiView protein in PROSITE
PS51286, RAP, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFASTK_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q14296
Secondary accession number(s): A8K867
, F8VTW9, Q59EM8, Q8IVA0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: November 1, 1996
Last modified: February 23, 2022
This is version 177 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  2. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  3. Human entries with genetic variants
    List of human entries with genetic variants
  4. Human variants curated from literature reports
    Index of human variants curated from literature reports
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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