UniProtKB - Q14289 (FAK2_HUMAN)
Protein-tyrosine kinase 2-beta
PTK2B
Functioni
Miscellaneous
Catalytic activityi
- ATP + L-tyrosyl-[protein] = ADP + H+ + O-phospho-L-tyrosyl-[protein]PROSITE-ProRule annotation6 PublicationsEC:2.7.10.2PROSITE-ProRule annotation6 Publications
Activity regulationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 457 | ATPCombined sources1 Publication | 1 | |
Active sitei | 549 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 431 – 439 | ATPCombined sources1 Publication | 9 | |
Nucleotide bindingi | 503 – 509 | ATPCombined sources1 Publication | 7 |
GO - Molecular functioni
- 3-phosphoinositide-dependent protein kinase binding Source: Ensembl
- ATP binding Source: UniProtKB-KW
- calmodulin-dependent protein kinase activity Source: Alzheimers_University_of_Toronto
- NMDA glutamate receptor activity Source: Ensembl
- non-membrane spanning protein tyrosine kinase activity Source: UniProtKB
- protein-containing complex binding Source: Ensembl
- protein C-terminus binding Source: UniProtKB
- protein tyrosine kinase activity Source: ProtInc
- signaling receptor binding Source: GO_Central
- ubiquitin protein ligase binding Source: Ensembl
GO - Biological processi
- activation of GTPase activity Source: Ensembl
- activation of Janus kinase activity Source: UniProtKB
- adaptive immune response Source: UniProtKB-KW
- angiogenesis Source: GO_Central
- apoptotic process Source: ProtInc
- blood vessel endothelial cell migration Source: Ensembl
- bone resorption Source: UniProtKB
- cell differentiation Source: GO_Central
- cell surface receptor signaling pathway Source: UniProtKB
- cellular defense response Source: Alzheimers_University_of_Toronto
- cellular response to fluid shear stress Source: Ensembl
- cellular response to retinoic acid Source: BHF-UCL
- chemokine-mediated signaling pathway Source: UniProtKB
- endothelin receptor signaling pathway Source: UniProtKB
- epidermal growth factor receptor signaling pathway Source: GO_Central
- focal adhesion assembly Source: Ensembl
- glial cell proliferation Source: Ensembl
- innate immune response Source: GO_Central
- integrin-mediated signaling pathway Source: UniProtKB
- interleukin-2-mediated signaling pathway Source: Reactome
- ionotropic glutamate receptor signaling pathway Source: Alzheimers_University_of_Toronto
- long-term synaptic depression Source: Ensembl
- long-term synaptic potentiation Source: Alzheimers_University_of_Toronto
- MAPK cascade Source: Ensembl
- marginal zone B cell differentiation Source: UniProtKB
- negative regulation of apoptotic process Source: UniProtKB
- negative regulation of bone mineralization Source: UniProtKB
- negative regulation of cell population proliferation Source: UniProtKB
- negative regulation of muscle cell apoptotic process Source: Ensembl
- negative regulation of myeloid cell differentiation Source: UniProtKB
- negative regulation of neuron apoptotic process Source: Alzheimers_University_of_Toronto
- negative regulation of potassium ion transport Source: UniProtKB
- neuron projection development Source: Ensembl
- oocyte maturation Source: Ensembl
- peptidyl-tyrosine autophosphorylation Source: BHF-UCL
- peptidyl-tyrosine phosphorylation Source: UniProtKB
- positive regulation of actin filament polymerization Source: UniProtKB
- positive regulation of angiogenesis Source: Ensembl
- positive regulation of B cell chemotaxis Source: UniProtKB
- positive regulation of cell growth Source: Ensembl
- positive regulation of cell-matrix adhesion Source: UniProtKB
- positive regulation of cell migration Source: UniProtKB
- positive regulation of cell population proliferation Source: UniProtKB
- positive regulation of cytosolic calcium ion concentration Source: Ensembl
- positive regulation of DNA biosynthetic process Source: Ensembl
- positive regulation of endothelial cell migration Source: BHF-UCL
- positive regulation of ERK1 and ERK2 cascade Source: UniProtKB
- positive regulation of excitatory postsynaptic potential Source: Alzheimers_University_of_Toronto
- positive regulation of JNK cascade Source: UniProtKB
- positive regulation of JUN kinase activity Source: Ensembl
- positive regulation of neuron projection development Source: BHF-UCL
- positive regulation of nitric oxide biosynthetic process Source: Ensembl
- positive regulation of nitric-oxide synthase activity Source: Ensembl
- positive regulation of peptidyl-tyrosine phosphorylation Source: UniProtKB
- positive regulation of phosphatidylinositol 3-kinase activity Source: UniProtKB
- positive regulation of protein kinase activity Source: UniProtKB
- positive regulation of synaptic transmission, glutamatergic Source: Alzheimers_University_of_Toronto
- positive regulation of translation Source: Ensembl
- positive regulation of ubiquitin-dependent protein catabolic process Source: Ensembl
- protein autophosphorylation Source: UniProtKB
- protein-containing complex assembly Source: ProtInc
- protein phosphorylation Source: ProtInc
- regulation of actin cytoskeleton reorganization Source: UniProtKB
- regulation of calcium-mediated signaling Source: Ensembl
- regulation of cell adhesion Source: UniProtKB
- regulation of cell population proliferation Source: GO_Central
- regulation of cell shape Source: UniProtKB
- regulation of cGMP-mediated signaling Source: Ensembl
- regulation of establishment of cell polarity Source: UniProtKB
- regulation of inositol trisphosphate biosynthetic process Source: UniProtKB
- regulation of macrophage chemotaxis Source: UniProtKB
- regulation of NMDA receptor activity Source: Alzheimers_University_of_Toronto
- regulation of release of sequestered calcium ion into cytosol Source: UniProtKB
- regulation of synaptic plasticity Source: ARUK-UCL
- regulation of ubiquitin-dependent protein catabolic process Source: UniProtKB
- response to calcium ion Source: Ensembl
- response to cAMP Source: Ensembl
- response to cocaine Source: Ensembl
- response to drug Source: Ensembl
- response to ethanol Source: Ensembl
- response to glucose Source: Ensembl
- response to hormone Source: Ensembl
- response to hydrogen peroxide Source: Ensembl
- response to hypoxia Source: Ensembl
- response to immobilization stress Source: Ensembl
- response to lithium ion Source: Ensembl
- response to mechanical stimulus Source: Ensembl
- response to osmotic stress Source: Ensembl
- signal complex assembly Source: ProtInc
- signal transduction Source: ProtInc
- sprouting angiogenesis Source: UniProtKB
- stress fiber assembly Source: Ensembl
- transmembrane receptor protein tyrosine kinase signaling pathway Source: GO_Central
- tumor necrosis factor-mediated signaling pathway Source: UniProtKB
- vascular endothelial growth factor receptor signaling pathway Source: BHF-UCL
Keywordsi
Molecular function | Kinase, Transferase, Tyrosine-protein kinase |
Biological process | Adaptive immunity, Angiogenesis, Immunity |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BRENDAi | 2.7.10.2, 2681 |
PathwayCommonsi | Q14289 |
Reactomei | R-HSA-391160, Signal regulatory protein family interactions R-HSA-4420097, VEGFA-VEGFR2 Pathway R-HSA-9020558, Interleukin-2 signaling |
SignaLinki | Q14289 |
SIGNORi | Q14289 |
Names & Taxonomyi
Protein namesi | Recommended name: Protein-tyrosine kinase 2-beta (EC:2.7.10.2)Alternative name(s): Calcium-dependent tyrosine kinase Short name: CADTK Calcium-regulated non-receptor proline-rich tyrosine kinase Cell adhesion kinase beta Short name: CAK-beta Short name: CAKB Focal adhesion kinase 2 Short name: FADK 2 Proline-rich tyrosine kinase 2 Related adhesion focal tyrosine kinase Short name: RAFTK |
Gene namesi | Name:PTK2B Synonyms:FAK2, PYK2, RAFTK |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:9612, PTK2B |
MIMi | 601212, gene |
neXtProti | NX_Q14289 |
VEuPathDBi | HostDB:ENSG00000120899.17 |
Subcellular locationi
Plasma membrane
Nucleus
Other locations
Note: Interaction with NPHP1 induces the membrane-association of the kinase. Colocalizes with integrins at the cell periphery.
Cytoskeleton
- cytoskeleton Source: InterPro
Cytosol
- cytosol Source: Reactome
Nucleus
- nucleus Source: UniProtKB
Plasma Membrane
- extrinsic component of cytoplasmic side of plasma membrane Source: GO_Central
- NMDA selective glutamate receptor complex Source: Alzheimers_University_of_Toronto
Other locations
- apical dendrite Source: Alzheimers_University_of_Toronto
- cell body Source: Alzheimers_University_of_Toronto
- cell cortex Source: UniProtKB-SubCell
- cytoplasm Source: ProtInc
- dendrite Source: Alzheimers_University_of_Toronto
- dendritic spine Source: GO_Central
- focal adhesion Source: UniProtKB
- glutamatergic synapse Source: Ensembl
- growth cone Source: Alzheimers_University_of_Toronto
- lamellipodium Source: UniProtKB
- membrane raft Source: Ensembl
- neuronal cell body Source: Alzheimers_University_of_Toronto
- perinuclear region of cytoplasm Source: UniProtKB
- postsynaptic density Source: Alzheimers_University_of_Toronto
Keywords - Cellular componenti
Cell junction, Cell membrane, Cell projection, Cytoplasm, Membrane, NucleusPathology & Biotechi
Involvement in diseasei
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 402 | Y → F: Abolishes autophosphorylation. Abolishes interaction with SRC. 1 Publication | 1 | |
Mutagenesisi | 457 | K → A: Abolishes kinase activity. 1 Publication | 1 | |
Mutagenesisi | 859 | P → A: Loss of interaction with NPHP1. 1 Publication | 1 | |
Mutagenesisi | 881 | Y → F: Loss of phosphorylation site. Strongly reduced interaction with GRB2. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 2185 |
NIAGADSi | ENSG00000120899 |
OpenTargetsi | ENSG00000120899 |
PharmGKBi | PA33956 |
Miscellaneous databases
Pharosi | Q14289, Tchem |
Chemistry databases
ChEMBLi | CHEMBL5469 |
DrugBanki | DB08341, 4-{[4-{[(1R,2R)-2-(dimethylamino)cyclopentyl]amino}-5-(trifluoromethyl)pyrimidin-2-yl]amino}-N-methylbenzenesulfonamide DB11817, Baricitinib DB12010, Fostamatinib DB01645, Genistein DB01097, Leflunomide |
DrugCentrali | Q14289 |
GuidetoPHARMACOLOGYi | 2181 |
Genetic variation databases
BioMutai | PTK2B |
DMDMi | 3183003 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000088081 | 1 – 1009 | Protein-tyrosine kinase 2-betaAdd BLAST | 1009 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 361 | PhosphoserineCombined sources | 1 | |
Modified residuei | 375 | PhosphoserineCombined sources | 1 | |
Modified residuei | 399 | PhosphoserineCombined sources | 1 | |
Modified residuei | 402 | Phosphotyrosine; by autocatalysis7 Publications | 1 | |
Modified residuei | 579 | PhosphotyrosineBy similarity | 1 | |
Modified residuei | 580 | Phosphotyrosine; by SRC, FYN and LCK2 Publications | 1 | |
Modified residuei | 722 | PhosphotyrosineCombined sources | 1 | |
Modified residuei | 762 | PhosphoserineCombined sources | 1 | |
Modified residuei | 765 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 819 | PhosphotyrosineCombined sources | 1 | |
Modified residuei | 834 | PhosphotyrosineCombined sources | 1 | |
Modified residuei | 839 | PhosphoserineCombined sources | 1 | |
Modified residuei | 842 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 849 | PhosphotyrosineCombined sources | 1 | |
Modified residuei | 866 | PhosphoserineCombined sources | 1 | |
Modified residuei | 881 | Phosphotyrosine; by SRC1 Publication | 1 |
Post-translational modificationi
Keywords - PTMi
PhosphoproteinProteomic databases
CPTACi | CPTAC-1791 |
EPDi | Q14289 |
jPOSTi | Q14289 |
MassIVEi | Q14289 |
MaxQBi | Q14289 |
PaxDbi | Q14289 |
PeptideAtlasi | Q14289 |
PRIDEi | Q14289 |
ProteomicsDBi | 59955 [Q14289-1] 59956 [Q14289-2] |
TopDownProteomicsi | Q14289-2 [Q14289-2] |
PTM databases
iPTMneti | Q14289 |
PhosphoSitePlusi | Q14289 |
SwissPalmi | Q14289 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000120899, Expressed in right hemisphere of cerebellum and 208 other tissues |
ExpressionAtlasi | Q14289, baseline and differential |
Genevisiblei | Q14289, HS |
Organism-specific databases
HPAi | ENSG00000120899, Tissue enhanced (bone marrow, brain) |
Interactioni
Subunit structurei
Homodimer, or homooligomer.
Interacts with SIRPA and SH2D3C.
Interacts with ARHGAP10.
Interacts with DLG4 (By similarity).
Interacts with KCNA2 (By similarity).
Interacts with NPHP1, ASAP1, ASAP2, ARHGAP26, SKAP2 and TGFB1I1. The Tyr-402 phosphorylated form interacts with SRC (via SH2 domain) and SRC family members.
Forms a signaling complex with EPHA1, LCK and phosphatidylinositol 3-kinase; upon activation by EFNA1.
Interacts with GRB2 (via SH2 domain).
Interacts with P53/TP53 and MDM2.
Interacts with MYLK.
Interacts with BCAR1.
Interacts with PDPK1.
Interacts (hypophosphorylated) with PXN.
Interacts with RB1CC1.
Interacts with RHOU.
Interacts with VAV1.
Interacts with LPXN and PTPN12.
By similarity21 PublicationsBinary interactionsi
Hide detailsQ14289
GO - Molecular functioni
- 3-phosphoinositide-dependent protein kinase binding Source: Ensembl
- protein C-terminus binding Source: UniProtKB
- signaling receptor binding Source: GO_Central
- ubiquitin protein ligase binding Source: Ensembl
Protein-protein interaction databases
BioGRIDi | 108480, 68 interactors |
CORUMi | Q14289 |
ELMi | Q14289 |
IntActi | Q14289, 38 interactors |
MINTi | Q14289 |
STRINGi | 9606.ENSP00000380638 |
Chemistry databases
BindingDBi | Q14289 |
Miscellaneous databases
RNActi | Q14289, protein |
Structurei
Secondary structure
3D structure databases
BMRBi | Q14289 |
SMRi | Q14289 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q14289 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 39 – 359 | FERMPROSITE-ProRule annotationAdd BLAST | 321 | |
Domaini | 425 – 683 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 259 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 801 – 1009 | Interaction with TGFB1I1By similarityAdd BLAST | 209 | |
Regioni | 868 – 1009 | Focal adhesion targeting (FAT)Add BLAST | 142 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 702 – 767 | Pro-richAdd BLAST | 66 | |
Compositional biasi | 831 – 869 | Pro-richAdd BLAST | 39 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG4257, Eukaryota |
GeneTreei | ENSGT00940000157269 |
HOGENOMi | CLU_002646_0_1_1 |
InParanoidi | Q14289 |
OMAi | IMELYSY |
OrthoDBi | 43729at2759 |
PhylomeDBi | Q14289 |
TreeFami | TF316643 |
Family and domain databases
CDDi | cd14473, FERM_B-lobe, 1 hit cd13190, FERM_C_FAK1, 1 hit |
Gene3Di | 1.20.80.10, 1 hit 2.30.29.30, 1 hit |
InterProi | View protein in InterPro IPR019749, Band_41_domain IPR041390, FADK_N IPR041784, FAK1/PYK2_FERM_C IPR014352, FERM/acyl-CoA-bd_prot_sf IPR035963, FERM_2 IPR019748, FERM_central IPR000299, FERM_domain IPR036137, Focal_adhe_kin_target_dom_sf IPR005189, Focal_adhesion_kin_target_dom IPR011009, Kinase-like_dom_sf IPR011993, PH-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR030610, PTK2B IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR008266, Tyr_kinase_AS IPR020635, Tyr_kinase_cat_dom IPR029071, Ubiquitin-like_domsf |
PANTHERi | PTHR24418:SF94, PTHR24418:SF94, 1 hit |
Pfami | View protein in Pfam PF00373, FERM_M, 1 hit PF18038, FERM_N_2, 1 hit PF03623, Focal_AT, 1 hit PF07714, PK_Tyr_Ser-Thr, 1 hit |
PRINTSi | PR00109, TYRKINASE |
SMARTi | View protein in SMART SM00295, B41, 1 hit SM00219, TyrKc, 1 hit |
SUPFAMi | SSF47031, SSF47031, 1 hit SSF54236, SSF54236, 1 hit SSF56112, SSF56112, 1 hit SSF68993, SSF68993, 1 hit |
PROSITEi | View protein in PROSITE PS50057, FERM_3, 1 hit PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00109, PROTEIN_KINASE_TYR, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSGVSEPLSR VKLGTLRRPE GPAEPMVVVP VDVEKEDVRI LKVCFYSNSF
60 70 80 90 100
NPGKNFKLVK CTVQTEIREI ITSILLSGRI GPNIRLAECY GLRLKHMKSD
110 120 130 140 150
EIHWLHPQMT VGEVQDKYEC LHVEAEWRYD LQIRYLPEDF MESLKEDRTT
160 170 180 190 200
LLYFYQQLRN DYMQRYASKV SEGMALQLGC LELRRFFKDM PHNALDKKSN
210 220 230 240 250
FELLEKEVGL DLFFPKQMQE NLKPKQFRKM IQQTFQQYAS LREEECVMKF
260 270 280 290 300
FNTLAGFANI DQETYRCELI QGWNITVDLV IGPKGIRQLT SQDAKPTCLA
310 320 330 340 350
EFKQIRSIRC LPLEEGQAVL QLGIEGAPQA LSIKTSSLAE AENMADLIDG
360 370 380 390 400
YCRLQGEHQG SLIIHPRKDG EKRNSLPQIP MLNLEARRSH LSESCSIESD
410 420 430 440 450
IYAEIPDETL RRPGGPQYGI AREDVVLNRI LGEGFFGEVY EGVYTNHKGE
460 470 480 490 500
KINVAVKTCK KDCTLDNKEK FMSEAVIMKN LDHPHIVKLI GIIEEEPTWI
510 520 530 540 550
IMELYPYGEL GHYLERNKNS LKVLTLVLYS LQICKAMAYL ESINCVHRDI
560 570 580 590 600
AVRNILVASP ECVKLGDFGL SRYIEDEDYY KASVTRLPIK WMSPESINFR
610 620 630 640 650
RFTTASDVWM FAVCMWEILS FGKQPFFWLE NKDVIGVLEK GDRLPKPDLC
660 670 680 690 700
PPVLYTLMTR CWDYDPSDRP RFTELVCSLS DVYQMEKDIA MEQERNARYR
710 720 730 740 750
TPKILEPTAF QEPPPKPSRP KYRPPPQTNL LAPKLQFQVP EGLCASSPTL
760 770 780 790 800
TSPMEYPSPV NSLHTPPLHR HNVFKRHSMR EEDFIQPSSR EEAQQLWEAE
810 820 830 840 850
KVKMRQILDK QQKQMVEDYQ WLRQEEKSLD PMVYMNDKSP LTPEKEVGYL
860 870 880 890 900
EFTGPPQKPP RLGAQSIQPT ANLDRTDDLV YLNVMELVRA VLELKNELCQ
910 920 930 940 950
LPPEGYVVVV KNVGLTLRKL IGSVDDLLPS LPSSSRTEIE GTQKLLNKDL
960 970 980 990 1000
AELINKMRLA QQNAVTSLSE ECKRQMLTAS HTLAVDAKNL LDAVDQAKVL
ANLAHPPAE
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketC9JHV9 | C9JHV9_HUMAN | Protein-tyrosine kinase 2-beta | PTK2B | 213 | Annotation score: | ||
E5RJ77 | E5RJ77_HUMAN | Protein-tyrosine kinase 2-beta | PTK2B | 184 | Annotation score: | ||
H0YB74 | H0YB74_HUMAN | Protein-tyrosine kinase 2-beta | PTK2B | 194 | Annotation score: | ||
E5RHL2 | E5RHL2_HUMAN | Protein-tyrosine kinase 2-beta | PTK2B | 68 | Annotation score: | ||
E5RK84 | E5RK84_HUMAN | Protein-tyrosine kinase 2-beta | PTK2B | 103 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 23 | A → G in BAA08289 (PubMed:7673154).Curated | 1 | |
Sequence conflicti | 23 | A → G in AAC05330 (PubMed:7673154).Curated | 1 | |
Sequence conflicti | 256 | G → P in AAB47217 (PubMed:8838818).Curated | 1 | |
Sequence conflicti | 435 | F → L in AAC05330 (PubMed:7673154).Curated | 1 | |
Sequence conflicti | 780 | R → G in AAB47217 (PubMed:8838818).Curated | 1 | |
Sequence conflicti | 985 | V → M in AAH36651 (PubMed:15489334).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_041687 | 359 | Q → E1 PublicationCorresponds to variant dbSNP:rs56175011EnsemblClinVar. | 1 | |
Natural variantiVAR_041688 | 698 | R → H1 PublicationCorresponds to variant dbSNP:rs35174236Ensembl. | 1 | |
Natural variantiVAR_041689 | 808 | L → P1 PublicationCorresponds to variant dbSNP:rs55747955Ensembl. | 1 | |
Natural variantiVAR_020284 | 838 | K → TCombined sources1 PublicationCorresponds to variant dbSNP:rs751019Ensembl. | 1 | |
Natural variantiVAR_041690 | 970 | E → K1 PublicationCorresponds to variant dbSNP:rs56263944Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_004981 | 739 – 780 | Missing in isoform 2. 1 PublicationAdd BLAST | 42 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U33284 mRNA Translation: AAC50203.1 L49207 mRNA Translation: AAB47217.1 D45853 mRNA Translation: BAA08289.1 U43522 mRNA Translation: AAC05330.1 S80542 mRNA Translation: AAB35701.1 AF311103 Genomic DNA No translation available. CH471080 Genomic DNA Translation: EAW63553.1 CH471080 Genomic DNA Translation: EAW63555.1 CH471080 Genomic DNA Translation: EAW63556.1 BC036651 mRNA Translation: AAH36651.1 BC042599 mRNA Translation: AAH42599.1 |
CCDSi | CCDS6057.1 [Q14289-1] CCDS6058.1 [Q14289-2] |
PIRi | S60248 |
RefSeqi | NP_004094.3, NM_004103.4 [Q14289-1] NP_775266.1, NM_173174.2 [Q14289-1] NP_775267.1, NM_173175.2 [Q14289-2] NP_775268.1, NM_173176.2 [Q14289-1] XP_005273504.1, XM_005273447.4 [Q14289-1] XP_011542743.1, XM_011544441.2 [Q14289-1] XP_016868703.1, XM_017013214.1 [Q14289-1] |
Genome annotation databases
Ensembli | ENST00000346049; ENSP00000332816; ENSG00000120899 [Q14289-1] ENST00000397501; ENSP00000380638; ENSG00000120899 [Q14289-1] ENST00000420218; ENSP00000391995; ENSG00000120899 [Q14289-2] ENST00000517339; ENSP00000427931; ENSG00000120899 [Q14289-2] |
GeneIDi | 2185 |
KEGGi | hsa:2185 |
UCSCi | uc003xfn.3, human [Q14289-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U33284 mRNA Translation: AAC50203.1 L49207 mRNA Translation: AAB47217.1 D45853 mRNA Translation: BAA08289.1 U43522 mRNA Translation: AAC05330.1 S80542 mRNA Translation: AAB35701.1 AF311103 Genomic DNA No translation available. CH471080 Genomic DNA Translation: EAW63553.1 CH471080 Genomic DNA Translation: EAW63555.1 CH471080 Genomic DNA Translation: EAW63556.1 BC036651 mRNA Translation: AAH36651.1 BC042599 mRNA Translation: AAH42599.1 |
CCDSi | CCDS6057.1 [Q14289-1] CCDS6058.1 [Q14289-2] |
PIRi | S60248 |
RefSeqi | NP_004094.3, NM_004103.4 [Q14289-1] NP_775266.1, NM_173174.2 [Q14289-1] NP_775267.1, NM_173175.2 [Q14289-2] NP_775268.1, NM_173176.2 [Q14289-1] XP_005273504.1, XM_005273447.4 [Q14289-1] XP_011542743.1, XM_011544441.2 [Q14289-1] XP_016868703.1, XM_017013214.1 [Q14289-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2FO6 | model | - | X | 45-350 | [»] | |
2LK4 | NMR | - | A | 871-1005 | [»] | |
3CC6 | X-ray | 1.60 | A | 414-692 | [»] | |
3ET7 | X-ray | 2.70 | A | 416-692 | [»] | |
3FZO | X-ray | 2.20 | A | 416-692 | [»] | |
3FZP | X-ray | 2.10 | A | 416-692 | [»] | |
3FZR | X-ray | 2.70 | A | 416-692 | [»] | |
3FZS | X-ray | 1.75 | A | 416-692 | [»] | |
3FZT | X-ray | 1.95 | A | 416-692 | [»] | |
3GM1 | X-ray | 2.95 | A/B | 861-1009 | [»] | |
3GM2 | X-ray | 2.71 | A | 861-1009 | [»] | |
3GM3 | X-ray | 2.60 | A | 861-1009 | [»] | |
3H3C | X-ray | 2.00 | A | 416-692 | [»] | |
3U3F | X-ray | 3.10 | A/B/C/D | 871-1005 | [»] | |
4EKU | X-ray | 3.25 | A | 21-409 | [»] | |
4H1J | X-ray | 2.00 | A | 416-692 | [»] | |
4H1M | X-ray | 1.99 | A | 416-692 | [»] | |
4R32 | X-ray | 3.50 | A | 871-1005 | [»] | |
4XEF | X-ray | 2.50 | A/D | 871-1005 | [»] | |
4XEK | X-ray | 1.79 | A | 871-1005 | [»] | |
4XEV | X-ray | 2.01 | A/D | 871-1005 | [»] | |
5TO8 | X-ray | 1.98 | A | 414-692 | [»] | |
5TOB | X-ray | 2.12 | A | 414-692 | [»] | |
6LF3 | X-ray | 3.20 | A/B/C/D/E/F | 790-839 | [»] | |
BMRBi | Q14289 | |||||
SMRi | Q14289 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 108480, 68 interactors |
CORUMi | Q14289 |
ELMi | Q14289 |
IntActi | Q14289, 38 interactors |
MINTi | Q14289 |
STRINGi | 9606.ENSP00000380638 |
Chemistry databases
BindingDBi | Q14289 |
ChEMBLi | CHEMBL5469 |
DrugBanki | DB08341, 4-{[4-{[(1R,2R)-2-(dimethylamino)cyclopentyl]amino}-5-(trifluoromethyl)pyrimidin-2-yl]amino}-N-methylbenzenesulfonamide DB11817, Baricitinib DB12010, Fostamatinib DB01645, Genistein DB01097, Leflunomide |
DrugCentrali | Q14289 |
GuidetoPHARMACOLOGYi | 2181 |
PTM databases
iPTMneti | Q14289 |
PhosphoSitePlusi | Q14289 |
SwissPalmi | Q14289 |
Genetic variation databases
BioMutai | PTK2B |
DMDMi | 3183003 |
Proteomic databases
CPTACi | CPTAC-1791 |
EPDi | Q14289 |
jPOSTi | Q14289 |
MassIVEi | Q14289 |
MaxQBi | Q14289 |
PaxDbi | Q14289 |
PeptideAtlasi | Q14289 |
PRIDEi | Q14289 |
ProteomicsDBi | 59955 [Q14289-1] 59956 [Q14289-2] |
TopDownProteomicsi | Q14289-2 [Q14289-2] |
Protocols and materials databases
Antibodypediai | 3551, 985 antibodies |
DNASUi | 2185 |
Genome annotation databases
Ensembli | ENST00000346049; ENSP00000332816; ENSG00000120899 [Q14289-1] ENST00000397501; ENSP00000380638; ENSG00000120899 [Q14289-1] ENST00000420218; ENSP00000391995; ENSG00000120899 [Q14289-2] ENST00000517339; ENSP00000427931; ENSG00000120899 [Q14289-2] |
GeneIDi | 2185 |
KEGGi | hsa:2185 |
UCSCi | uc003xfn.3, human [Q14289-1] |
Organism-specific databases
CTDi | 2185 |
DisGeNETi | 2185 |
GeneCardsi | PTK2B |
HGNCi | HGNC:9612, PTK2B |
HPAi | ENSG00000120899, Tissue enhanced (bone marrow, brain) |
MIMi | 601212, gene |
neXtProti | NX_Q14289 |
NIAGADSi | ENSG00000120899 |
OpenTargetsi | ENSG00000120899 |
PharmGKBi | PA33956 |
VEuPathDBi | HostDB:ENSG00000120899.17 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4257, Eukaryota |
GeneTreei | ENSGT00940000157269 |
HOGENOMi | CLU_002646_0_1_1 |
InParanoidi | Q14289 |
OMAi | IMELYSY |
OrthoDBi | 43729at2759 |
PhylomeDBi | Q14289 |
TreeFami | TF316643 |
Enzyme and pathway databases
BRENDAi | 2.7.10.2, 2681 |
PathwayCommonsi | Q14289 |
Reactomei | R-HSA-391160, Signal regulatory protein family interactions R-HSA-4420097, VEGFA-VEGFR2 Pathway R-HSA-9020558, Interleukin-2 signaling |
SignaLinki | Q14289 |
SIGNORi | Q14289 |
Miscellaneous databases
BioGRID-ORCSi | 2185, 8 hits in 906 CRISPR screens |
ChiTaRSi | PTK2B, human |
EvolutionaryTracei | Q14289 |
GeneWikii | PTK2B |
GenomeRNAii | 2185 |
Pharosi | Q14289, Tchem |
PROi | PR:Q14289 |
RNActi | Q14289, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000120899, Expressed in right hemisphere of cerebellum and 208 other tissues |
ExpressionAtlasi | Q14289, baseline and differential |
Genevisiblei | Q14289, HS |
Family and domain databases
CDDi | cd14473, FERM_B-lobe, 1 hit cd13190, FERM_C_FAK1, 1 hit |
Gene3Di | 1.20.80.10, 1 hit 2.30.29.30, 1 hit |
InterProi | View protein in InterPro IPR019749, Band_41_domain IPR041390, FADK_N IPR041784, FAK1/PYK2_FERM_C IPR014352, FERM/acyl-CoA-bd_prot_sf IPR035963, FERM_2 IPR019748, FERM_central IPR000299, FERM_domain IPR036137, Focal_adhe_kin_target_dom_sf IPR005189, Focal_adhesion_kin_target_dom IPR011009, Kinase-like_dom_sf IPR011993, PH-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR030610, PTK2B IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR008266, Tyr_kinase_AS IPR020635, Tyr_kinase_cat_dom IPR029071, Ubiquitin-like_domsf |
PANTHERi | PTHR24418:SF94, PTHR24418:SF94, 1 hit |
Pfami | View protein in Pfam PF00373, FERM_M, 1 hit PF18038, FERM_N_2, 1 hit PF03623, Focal_AT, 1 hit PF07714, PK_Tyr_Ser-Thr, 1 hit |
PRINTSi | PR00109, TYRKINASE |
SMARTi | View protein in SMART SM00295, B41, 1 hit SM00219, TyrKc, 1 hit |
SUPFAMi | SSF47031, SSF47031, 1 hit SSF54236, SSF54236, 1 hit SSF56112, SSF56112, 1 hit SSF68993, SSF68993, 1 hit |
PROSITEi | View protein in PROSITE PS50057, FERM_3, 1 hit PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00109, PROTEIN_KINASE_TYR, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | FAK2_HUMAN | |
Accessioni | Q14289Primary (citable) accession number: Q14289 Secondary accession number(s): D3DST0 Q6PID4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1998 |
Last sequence update: | July 15, 1998 | |
Last modified: | February 10, 2021 | |
This is version 232 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human and mouse protein kinases
Human and mouse protein kinases: classification and index - Human chromosome 8
Human chromosome 8: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families