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Protein

Flotillin-2

Gene

FLOT2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles. May be involved in epidermal cell adhesion and epidermal structure and function.

GO - Molecular functioni

  • ionotropic glutamate receptor binding Source: Ensembl
  • protease binding Source: Ensembl
  • protein heterodimerization activity Source: UniProtKB

GO - Biological processi

  • cell adhesion Source: ProtInc
  • epidermis development Source: ProtInc
  • membrane raft assembly Source: UniProtKB
  • negative regulation of amyloid precursor protein catabolic process Source: UniProtKB
  • negative regulation of gene expression Source: UniProtKB
  • positive regulation of establishment of T cell polarity Source: UniProtKB
  • protein localization to plasma membrane Source: UniProtKB
  • protein localization to plasma membrane raft Source: UniProtKB
  • protein stabilization Source: UniProtKB
  • regulation of myoblast differentiation Source: UniProtKB

Keywordsi

Biological processCell adhesion

Enzyme and pathway databases

ReactomeiR-HSA-8849932 Synaptic adhesion-like molecules

Names & Taxonomyi

Protein namesi
Recommended name:
Flotillin-2
Alternative name(s):
Epidermal surface antigen
Short name:
ESA
Membrane component chromosome 17 surface marker 1
Gene namesi
Name:FLOT2
Synonyms:ESA1, M17S1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000132589.15
HGNCiHGNC:3758 FLOT2
MIMi131560 gene
neXtProtiNX_Q14254

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Endosome, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi4C → S: Loss of ZDHHC5-catalyzed palmitoylation; when associated with S-20. Partial loss of ZDHHC5-catalyzed palmitoylation; when associated with S-19. Complete loss of palmitoylation; when associated with S-19 and S-20. 1 Publication1
Mutagenesisi19C → S: Partial loss of ZDHHC5-catalyzed palmitoylation; when associated with S-4 or S-20. Complete loss of palmitoylation; when associated with S-4 and S-20. 1 Publication1
Mutagenesisi20C → S: Loss of ZDHHC5-catalyzed palmitoylation; when associated with S-4. Partial loss of ZDHHC5-catalyzed palmitoylation; when associated with S-19. Complete loss of palmitoylation; when associated with S-4 and S-19. 1 Publication1

Organism-specific databases

DisGeNETi2319
OpenTargetsiENSG00000132589
PharmGKBiPA28176

Polymorphism and mutation databases

BioMutaiFLOT2
DMDMi254763294

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000940492 – 428Flotillin-2Add BLAST427

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycine1 Publication1
Lipidationi4S-palmitoyl cysteine; by ZDHHC51 Publication1
Lipidationi19S-palmitoyl cysteine1 Publication1
Lipidationi20S-palmitoyl cysteine; by ZDHHC51 Publication1
Modified residuei405PhosphoserineCombined sources1

Post-translational modificationi

ZDHHC5-catalyzed palmitoylation predominantly occurs at Cys-4. ZDHHC5-catalyzed palmitoylation may be required for the formation of higher-order complexes and for neurite outgrowth in cultured neural stem cells.1 Publication

Keywords - PTMi

Lipoprotein, Myristate, Palmitate, Phosphoprotein

Proteomic databases

EPDiQ14254
MaxQBiQ14254
PaxDbiQ14254
PeptideAtlasiQ14254
PRIDEiQ14254
ProteomicsDBi59951

PTM databases

iPTMnetiQ14254
PhosphoSitePlusiQ14254
SwissPalmiQ14254

Expressioni

Tissue specificityi

In skin, expressed in epidermis and epidermal appendages but not in dermis. Expressed in all layers of the epidermis except the basal layer. In hair follicles, expressed in the suprabasal layer but not the basal layer. Also expressed in melanoma and carcinoma cell lines, fibroblasts and foreskin melanocytes.

Gene expression databases

BgeeiENSG00000132589
CleanExiHS_FLOT2
ExpressionAtlasiQ14254 baseline and differential
GenevisibleiQ14254 HS

Organism-specific databases

HPAiCAB004395
HPA001396

Interactioni

Subunit structurei

Heterooligomeric complex of flotillin-1 and flotillin-2 and caveolin-1 and caveolin-2 (By similarity). Interacts with ECPAS.By similarity1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

  • ionotropic glutamate receptor binding Source: Ensembl
  • protease binding Source: Ensembl
  • protein heterodimerization activity Source: UniProtKB

Protein-protein interaction databases

BioGridi108608, 91 interactors
CORUMiQ14254
IntActiQ14254, 65 interactors
MINTiQ14254
STRINGi9606.ENSP00000378368

Structurei

3D structure databases

ProteinModelPortaliQ14254
SMRiQ14254
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2668 Eukaryota
COG2268 LUCA
GeneTreeiENSGT00560000077232
HOGENOMiHOG000240804
HOVERGENiHBG051628
InParanoidiQ14254
KOiK07192
PhylomeDBiQ14254
TreeFamiTF324879

Family and domain databases

InterProiView protein in InterPro
IPR001107 Band_7
IPR036013 Band_7/SPFH_dom_sf
IPR031905 Flotillin_C
IPR027705 Flotillin_fam
PANTHERiPTHR13806 PTHR13806, 1 hit
PfamiView protein in Pfam
PF01145 Band_7, 1 hit
PF15975 Flot, 1 hit
SMARTiView protein in SMART
SM00244 PHB, 1 hit
SUPFAMiSSF117892 SSF117892, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q14254-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGNCHTVGPN EALVVSGGCC GSDYKQYVFG GWAWAWWCIS DTQRISLEIM
60 70 80 90 100
TLQPRCEDVE TAEGVALTVT GVAQVKIMTE KELLAVACEQ FLGKNVQDIK
110 120 130 140 150
NVVLQTLEGH LRSILGTLTV EQIYQDRDQF AKLVREVAAP DVGRMGIEIL
160 170 180 190 200
SFTIKDVYDK VDYLSSLGKT QTAVVQRDAD IGVAEAERDA GIREAECKKE
210 220 230 240 250
MLDVKFMADT KIADSKRAFE LQKSAFSEEV NIKTAEAQLA YELQGAREQQ
260 270 280 290 300
KIRQEEIEIE VVQRKKQIAV EAQEILRTDK ELIATVRRPA EAEAHRIQQI
310 320 330 340 350
AEGEKVKQVL LAQAEAEKIR KIGEAEAAVI EAMGKAEAER MKLKAEAYQK
360 370 380 390 400
YGDAAKMALV LEALPQIAAK IAAPLTKVDE IVVLSGDNSK VTSEVNRLLA
410 420
ELPASVHALT GVDLSKIPLI KKATGVQV
Length:428
Mass (Da):47,064
Last modified:July 28, 2009 - v2
Checksum:iF690BFE0151D3BD7
GO

Sequence cautioni

The sequence AAA65729 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti8G → R in AC024267 (PubMed:16625196).Curated1
Sequence conflicti8G → R in AAA65729 (PubMed:8051082).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_024375328A → T. Corresponds to variant dbSNP:rs3736238Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC024267 Genomic DNA No translation available.
M60922 mRNA Translation: AAA65729.1 Different initiation.
BC017292 mRNA Translation: AAH17292.2
BT019478 mRNA Translation: AAV38285.1
CCDSiCCDS11245.2
PIRiA53664
RefSeqiNP_004466.2, NM_004475.2
XP_016879883.1, XM_017024394.1
XP_016879884.1, XM_017024395.1
UniGeneiHs.514038

Genome annotation databases

EnsembliENST00000394908; ENSP00000378368; ENSG00000132589
GeneIDi2319
KEGGihsa:2319
UCSCiuc002hdc.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiFLOT2_HUMAN
AccessioniPrimary (citable) accession number: Q14254
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: July 28, 2009
Last modified: July 18, 2018
This is version 158 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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