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Protein

Endonuclease G, mitochondrial

Gene

ENDOG

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cleaves DNA at double-stranded (DG)n.(DC)n and at single-stranded (DC)n tracts. In addition to deoxyribonuclease activities, also has ribonuclease (RNase) and RNase H activities. Capable of generating the RNA primers required by DNA polymerase gamma to initiate replication of mitochondrial DNA (By similarity).By similarity

Miscellaneous

The active site contains 1 hydrated divalent metal cation that has only 1 direct interaction with the protein; all other interactions are via water molecules.By similarity

Cofactori

Mn2+By similarity, Mg2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei141Proton acceptorPROSITE-ProRule annotation1
Metal bindingi172Magnesium or manganese; catalyticBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionEndonuclease, Hydrolase, Nuclease
LigandMagnesium, Manganese, Metal-binding

Enzyme and pathway databases

SIGNORiQ14249

Names & Taxonomyi

Protein namesi
Recommended name:
Endonuclease G, mitochondrial (EC:3.1.30.-)
Short name:
Endo G
Gene namesi
Name:ENDOG
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000167136.6
HGNCiHGNC:3346 ENDOG
MIMi600440 gene
neXtProtiNX_Q14249

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

DisGeNETi2021
OpenTargetsiENSG00000167136
PharmGKBiPA27783

Chemistry databases

ChEMBLiCHEMBL3804749

Polymorphism and mutation databases

BioMutaiENDOG
DMDMi317373579

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 48MitochondrionBy similarityAdd BLAST48
ChainiPRO_000001991849 – 297Endonuclease G, mitochondrialAdd BLAST249

Proteomic databases

EPDiQ14249
MaxQBiQ14249
PaxDbiQ14249
PeptideAtlasiQ14249
PRIDEiQ14249
ProteomicsDBi59950

PTM databases

iPTMnetiQ14249
PhosphoSitePlusiQ14249

Expressioni

Gene expression databases

BgeeiENSG00000167136 Expressed in 201 organ(s), highest expression level in gastrocnemius
CleanExiHS_ENDOG
ExpressionAtlasiQ14249 baseline and differential
GenevisibleiQ14249 HS

Organism-specific databases

HPAiHPA021335
HPA021830

Interactioni

Subunit structurei

Homodimer.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
DNAJA4Q8WW222EBI-9369928,EBI-2555157

Protein-protein interaction databases

BioGridi108336, 28 interactors
IntActiQ14249, 8 interactors
STRINGi9606.ENSP00000361725

Structurei

3D structure databases

ProteinModelPortaliQ14249
SMRiQ14249
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG3721 Eukaryota
COG1864 LUCA
GeneTreeiENSGT00530000063772
HOGENOMiHOG000214172
HOVERGENiHBG002851
InParanoidiQ14249
KOiK01173
OMAiVPHWVFE
OrthoDBiEOG091G0BHG
PhylomeDBiQ14249
TreeFamiTF105386

Family and domain databases

InterProiView protein in InterPro
IPR018524 DNA/RNA_endonuclease_AS
IPR001604 DNA/RNA_non-sp_Endonuclease
IPR020821 Extracellular_endonuc_su_A
PfamiView protein in Pfam
PF01223 Endonuclease_NS, 1 hit
SMARTiView protein in SMART
SM00892 Endonuclease_NS, 1 hit
SM00477 NUC, 1 hit
PROSITEiView protein in PROSITE
PS01070 NUCLEASE_NON_SPEC, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q14249-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRALRAGLTL ASGAGLGAVV EGWRRRREDA RAAPGLLGRL PVLPVAAAAE
60 70 80 90 100
LPPVPGGPRG PGELAKYGLP GLAQLKSRES YVLCYDPRTR GALWVVEQLR
110 120 130 140 150
PERLRGDGDR RECDFREDDS VHAYHRATNA DYRGSGFDRG HLAAAANHRW
160 170 180 190 200
SQKAMDDTFY LSNVAPQVPH LNQNAWNNLE KYSRSLTRSY QNVYVCTGPL
210 220 230 240 250
FLPRTEADGK SYVKYQVIGK NHVAVPTHFF KVLILEAAGG QIELRTYVMP
260 270 280 290
NAPVDEAIPL ERFLVPIESI ERASGLLFVP NILARAGSLK AITAGSK
Length:297
Mass (Da):32,620
Last modified:January 11, 2011 - v4
Checksum:i33015E8A619781B7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti34P → L in CAA55963 (Ref. 1) Curated1
Sequence conflicti163N → K in CAA55963 (Ref. 1) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03169112S → L1 PublicationCorresponds to variant dbSNP:rs2293969Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X79444 mRNA Translation: CAA55963.1
AL441992 Genomic DNA No translation available.
BC004922 mRNA Translation: AAH04922.1
BC016351 mRNA Translation: AAH16351.1
CCDSiCCDS6912.1
PIRiT09542
RefSeqiNP_004426.2, NM_004435.2
UniGeneiHs.745161

Genome annotation databases

EnsembliENST00000372642; ENSP00000361725; ENSG00000167136
GeneIDi2021
KEGGihsa:2021
UCSCiuc004bwc.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X79444 mRNA Translation: CAA55963.1
AL441992 Genomic DNA No translation available.
BC004922 mRNA Translation: AAH04922.1
BC016351 mRNA Translation: AAH16351.1
CCDSiCCDS6912.1
PIRiT09542
RefSeqiNP_004426.2, NM_004435.2
UniGeneiHs.745161

3D structure databases

ProteinModelPortaliQ14249
SMRiQ14249
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108336, 28 interactors
IntActiQ14249, 8 interactors
STRINGi9606.ENSP00000361725

Chemistry databases

ChEMBLiCHEMBL3804749

PTM databases

iPTMnetiQ14249
PhosphoSitePlusiQ14249

Polymorphism and mutation databases

BioMutaiENDOG
DMDMi317373579

Proteomic databases

EPDiQ14249
MaxQBiQ14249
PaxDbiQ14249
PeptideAtlasiQ14249
PRIDEiQ14249
ProteomicsDBi59950

Protocols and materials databases

DNASUi2021
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000372642; ENSP00000361725; ENSG00000167136
GeneIDi2021
KEGGihsa:2021
UCSCiuc004bwc.4 human

Organism-specific databases

CTDi2021
DisGeNETi2021
EuPathDBiHostDB:ENSG00000167136.6
GeneCardsiENDOG
H-InvDBiHIX0008437
HIX0008438
HGNCiHGNC:3346 ENDOG
HPAiHPA021335
HPA021830
MIMi600440 gene
neXtProtiNX_Q14249
OpenTargetsiENSG00000167136
PharmGKBiPA27783
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3721 Eukaryota
COG1864 LUCA
GeneTreeiENSGT00530000063772
HOGENOMiHOG000214172
HOVERGENiHBG002851
InParanoidiQ14249
KOiK01173
OMAiVPHWVFE
OrthoDBiEOG091G0BHG
PhylomeDBiQ14249
TreeFamiTF105386

Enzyme and pathway databases

SIGNORiQ14249

Miscellaneous databases

GeneWikiiENDOG
GenomeRNAii2021
PROiPR:Q14249
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000167136 Expressed in 201 organ(s), highest expression level in gastrocnemius
CleanExiHS_ENDOG
ExpressionAtlasiQ14249 baseline and differential
GenevisibleiQ14249 HS

Family and domain databases

InterProiView protein in InterPro
IPR018524 DNA/RNA_endonuclease_AS
IPR001604 DNA/RNA_non-sp_Endonuclease
IPR020821 Extracellular_endonuc_su_A
PfamiView protein in Pfam
PF01223 Endonuclease_NS, 1 hit
SMARTiView protein in SMART
SM00892 Endonuclease_NS, 1 hit
SM00477 NUC, 1 hit
PROSITEiView protein in PROSITE
PS01070 NUCLEASE_NON_SPEC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNUCG_HUMAN
AccessioniPrimary (citable) accession number: Q14249
Secondary accession number(s): Q5T281, Q9BSP2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 11, 2011
Last modified: November 7, 2018
This is version 152 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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