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Entry version 155 (13 Feb 2019)
Sequence version 4 (11 Jan 2011)
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Protein

Endonuclease G, mitochondrial

Gene

ENDOG

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Cleaves DNA at double-stranded (DG)n.(DC)n and at single-stranded (DC)n tracts. In addition to deoxyribonuclease activities, also has ribonuclease (RNase) and RNase H activities. Capable of generating the RNA primers required by DNA polymerase gamma to initiate replication of mitochondrial DNA (By similarity).By similarity

Miscellaneous

The active site contains 1 hydrated divalent metal cation that has only 1 direct interaction with the protein; all other interactions are via water molecules.By similarity

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mn2+By similarity, Mg2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei141Proton acceptorPROSITE-ProRule annotation1
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi172Magnesium or manganese; catalyticBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionEndonuclease, Hydrolase, Nuclease
LigandMagnesium, Manganese, Metal-binding

Enzyme and pathway databases

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q14249

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Endonuclease G, mitochondrial (EC:3.1.30.-)
Short name:
Endo G
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ENDOG
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000167136.6

Human Gene Nomenclature Database

More...
HGNCi
HGNC:3346 ENDOG

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
600440 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q14249

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
2021

Open Targets

More...
OpenTargetsi
ENSG00000167136

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA27783

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3804749

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ENDOG

Domain mapping of disease mutations (DMDM)

More...
DMDMi
317373579

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 48MitochondrionBy similarityAdd BLAST48
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001991849 – 297Endonuclease G, mitochondrialAdd BLAST249

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q14249

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q14249

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q14249

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q14249

PeptideAtlas

More...
PeptideAtlasi
Q14249

PRoteomics IDEntifications database

More...
PRIDEi
Q14249

ProteomicsDB human proteome resource

More...
ProteomicsDBi
59950

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q14249

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q14249

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000167136 Expressed in 201 organ(s), highest expression level in gastrocnemius

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q14249 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q14249 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA021335
HPA021830

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
DNAJA4Q8WW222EBI-9369928,EBI-2555157

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
108336, 28 interactors

Protein interaction database and analysis system

More...
IntActi
Q14249, 8 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000361725

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q14249

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q14249

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3721 Eukaryota
COG1864 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160987

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000214172

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG002851

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q14249

KEGG Orthology (KO)

More...
KOi
K01173

Identification of Orthologs from Complete Genome Data

More...
OMAi
VPHWVFE

Database of Orthologous Groups

More...
OrthoDBi
933605at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q14249

TreeFam database of animal gene trees

More...
TreeFami
TF105386

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR018524 DNA/RNA_endonuclease_AS
IPR001604 DNA/RNA_non-sp_Endonuclease
IPR020821 Extracellular_endonuc_su_A
IPR040255 Non-specific_endonuclease

The PANTHER Classification System

More...
PANTHERi
PTHR13966 PTHR13966, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01223 Endonuclease_NS, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00892 Endonuclease_NS, 1 hit
SM00477 NUC, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01070 NUCLEASE_NON_SPEC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q14249-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRALRAGLTL ASGAGLGAVV EGWRRRREDA RAAPGLLGRL PVLPVAAAAE
60 70 80 90 100
LPPVPGGPRG PGELAKYGLP GLAQLKSRES YVLCYDPRTR GALWVVEQLR
110 120 130 140 150
PERLRGDGDR RECDFREDDS VHAYHRATNA DYRGSGFDRG HLAAAANHRW
160 170 180 190 200
SQKAMDDTFY LSNVAPQVPH LNQNAWNNLE KYSRSLTRSY QNVYVCTGPL
210 220 230 240 250
FLPRTEADGK SYVKYQVIGK NHVAVPTHFF KVLILEAAGG QIELRTYVMP
260 270 280 290
NAPVDEAIPL ERFLVPIESI ERASGLLFVP NILARAGSLK AITAGSK
Length:297
Mass (Da):32,620
Last modified:January 11, 2011 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i33015E8A619781B7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti34P → L in CAA55963 (Ref. 1) Curated1
Sequence conflicti163N → K in CAA55963 (Ref. 1) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03169112S → L1 PublicationCorresponds to variant dbSNP:rs2293969Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X79444 mRNA Translation: CAA55963.1
AL441992 Genomic DNA No translation available.
BC004922 mRNA Translation: AAH04922.1
BC016351 mRNA Translation: AAH16351.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS6912.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T09542

NCBI Reference Sequences

More...
RefSeqi
NP_004426.2, NM_004435.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.745161

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000372642; ENSP00000361725; ENSG00000167136

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2021

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:2021

UCSC genome browser

More...
UCSCi
uc004bwc.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X79444 mRNA Translation: CAA55963.1
AL441992 Genomic DNA No translation available.
BC004922 mRNA Translation: AAH04922.1
BC016351 mRNA Translation: AAH16351.1
CCDSiCCDS6912.1
PIRiT09542
RefSeqiNP_004426.2, NM_004435.2
UniGeneiHs.745161

3D structure databases

ProteinModelPortaliQ14249
SMRiQ14249
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108336, 28 interactors
IntActiQ14249, 8 interactors
STRINGi9606.ENSP00000361725

Chemistry databases

ChEMBLiCHEMBL3804749

PTM databases

iPTMnetiQ14249
PhosphoSitePlusiQ14249

Polymorphism and mutation databases

BioMutaiENDOG
DMDMi317373579

Proteomic databases

EPDiQ14249
jPOSTiQ14249
MaxQBiQ14249
PaxDbiQ14249
PeptideAtlasiQ14249
PRIDEiQ14249
ProteomicsDBi59950

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
2021
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000372642; ENSP00000361725; ENSG00000167136
GeneIDi2021
KEGGihsa:2021
UCSCiuc004bwc.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
2021
DisGeNETi2021
EuPathDBiHostDB:ENSG00000167136.6

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ENDOG

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0008437
HIX0008438
HGNCiHGNC:3346 ENDOG
HPAiHPA021335
HPA021830
MIMi600440 gene
neXtProtiNX_Q14249
OpenTargetsiENSG00000167136
PharmGKBiPA27783

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3721 Eukaryota
COG1864 LUCA
GeneTreeiENSGT00940000160987
HOGENOMiHOG000214172
HOVERGENiHBG002851
InParanoidiQ14249
KOiK01173
OMAiVPHWVFE
OrthoDBi933605at2759
PhylomeDBiQ14249
TreeFamiTF105386

Enzyme and pathway databases

SIGNORiQ14249

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
ENDOG

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
2021

Protein Ontology

More...
PROi
PR:Q14249

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000167136 Expressed in 201 organ(s), highest expression level in gastrocnemius
ExpressionAtlasiQ14249 baseline and differential
GenevisibleiQ14249 HS

Family and domain databases

InterProiView protein in InterPro
IPR018524 DNA/RNA_endonuclease_AS
IPR001604 DNA/RNA_non-sp_Endonuclease
IPR020821 Extracellular_endonuc_su_A
IPR040255 Non-specific_endonuclease
PANTHERiPTHR13966 PTHR13966, 1 hit
PfamiView protein in Pfam
PF01223 Endonuclease_NS, 1 hit
SMARTiView protein in SMART
SM00892 Endonuclease_NS, 1 hit
SM00477 NUC, 1 hit
PROSITEiView protein in PROSITE
PS01070 NUCLEASE_NON_SPEC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNUCG_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q14249
Secondary accession number(s): Q5T281, Q9BSP2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 11, 2011
Last modified: February 13, 2019
This is version 155 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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