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Protein

Elongin-A

Gene

ELOA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex).1 Publication

Caution

It is uncertain whether Met-1 or Met-27 is the initiator.Curated

GO - Biological processi

Keywordsi

Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-112382 Formation of RNA Pol II elongation complex
R-HSA-167152 Formation of HIV elongation complex in the absence of HIV Tat
R-HSA-167200 Formation of HIV-1 elongation complex containing HIV-1 Tat
R-HSA-167238 Pausing and recovery of Tat-mediated HIV elongation
R-HSA-167243 Tat-mediated HIV elongation arrest and recovery
R-HSA-167246 Tat-mediated elongation of the HIV-1 transcript
R-HSA-167287 HIV elongation arrest and recovery
R-HSA-167290 Pausing and recovery of HIV elongation
R-HSA-674695 RNA Polymerase II Pre-transcription Events
R-HSA-6796648 TP53 Regulates Transcription of DNA Repair Genes
R-HSA-75955 RNA Polymerase II Transcription Elongation

Names & Taxonomyi

Protein namesi
Recommended name:
Elongin-A
Short name:
EloA
Alternative name(s):
Elongin 110 kDa subunit
RNA polymerase II transcription factor SIII subunit A1
SIII p110
Transcription elongation factor B polypeptide 3
Gene namesi
Name:ELOAImported
Synonyms:TCEB3
ORF Names:MSTP059
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000011007.12
HGNCiHGNC:11620 ELOA
MIMi600786 gene
neXtProtiNX_Q14241

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi6924
OpenTargetsiENSG00000011007
PharmGKBiPA36379

Polymorphism and mutation databases

BioMutaiTCEB3
DMDMi294862430

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000869601 – 798Elongin-AAdd BLAST798

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei222PhosphoserineBy similarity1
Modified residuei410PhosphoserineCombined sources1
Modified residuei413PhosphoserineCombined sources1
Modified residuei420PhosphothreonineCombined sources1
Modified residuei460N6-acetyllysineBy similarity1
Modified residuei542PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ14241
MaxQBiQ14241
PaxDbiQ14241
PeptideAtlasiQ14241
PRIDEiQ14241
ProteomicsDBi59938

PTM databases

iPTMnetiQ14241
PhosphoSitePlusiQ14241

Expressioni

Gene expression databases

BgeeiENSG00000011007 Expressed in 240 organ(s), highest expression level in upper lobe of lung
ExpressionAtlasiQ14241 baseline and differential
GenevisibleiQ14241 HS

Organism-specific databases

HPAiHPA005910

Interactioni

Subunit structurei

Heterotrimer of an A (ELOA, ELOA2 or ELOA3), ELOB and ELOC subunit.By similarity

Binary interactionsi

Protein-protein interaction databases

BioGridi112786, 59 interactors
IntActiQ14241, 56 interactors
MINTiQ14241
STRINGi9606.ENSP00000395574

Structurei

Secondary structure

1798
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ14241
SMRiQ14241
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 105TFIIS N-terminalPROSITE-ProRule annotationAdd BLAST76
Domaini592 – 636F-boxPROSITE-ProRule annotationAdd BLAST45

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni548 – 707Activation domainBy similarityAdd BLAST160
Regioni576 – 585BC-boxBy similarity10

Domaini

The BC-box, which mediates binding to the elongin BC complex, has the consensus sequence [APST]-L-x3-C-x3-[AILV].By similarity

Phylogenomic databases

eggNOGiKOG2821 Eukaryota
ENOG4110PG3 LUCA
GeneTreeiENSGT00390000002428
HOGENOMiHOG000059565
HOVERGENiHBG051467
InParanoidiQ14241
KOiK15076
OMAiHLQETGI
OrthoDBiEOG091G0D2G
PhylomeDBiQ14241
TreeFamiTF317259

Family and domain databases

Gene3Di1.20.930.10, 1 hit
InterProiView protein in InterPro
IPR001810 F-box_dom
IPR010684 RNA_pol_II_trans_fac_SIII_A
IPR003617 TFIIS/CRSP70_N_sub
IPR035441 TFIIS/LEDGF_dom_sf
IPR017923 TFIIS_N
PfamiView protein in Pfam
PF06881 Elongin_A, 1 hit
PF08711 Med26, 1 hit
SMARTiView protein in SMART
SM00509 TFS2N, 1 hit
SUPFAMiSSF47676 SSF47676, 1 hit
PROSITEiView protein in PROSITE
PS50181 FBOX, 1 hit
PS51319 TFIIS_N, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q14241-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MHGGRSCGPR TRREPSSGEE AAPVTAMAAE SALQVVEKLQ ARLAANPDPK
60 70 80 90 100
KLLKYLKKLS TLPITVDILA ETGVGKTVNS LRKHEHVGSF ARDLVAQWKK
110 120 130 140 150
LVPVERNAEP DEQDFEKSNS RKRPRDALQK EEEMEGDYQE TWKATGSRSY
160 170 180 190 200
SPDHRQKKHR KLSELERPHK VSHGHERRDE RKRCHRMSPT YSSDPESSDY
210 220 230 240 250
GHVQSPPSCT SPHQMYVDHY RSLEEDQEPI VSHQKPGKGH SNAFQDRLGA
260 270 280 290 300
SQERHLGEPH GKGVVSQNKE HKSSHKDKRP VDAKSDEKAS VVSREKSHKA
310 320 330 340 350
LSKEENRRPP SGDNAREKPP SSGVKKEKDR EGSSLKKKCL PPSEAASDNH
360 370 380 390 400
LKKPKHRDPE KAKLDKSKQG LDSFDTGKGA GDLLPKVKEK GSNNLKTPEG
410 420 430 440 450
KVKTNLDRKS LGSLPKVEET DMEDEFEQPT MSFESYLSYD QPRKKKKKIV
460 470 480 490 500
KTSATALGDK GLKKNDSKST GKNLDSVQKL PKVNKTKSEK PAGADLAKLR
510 520 530 540 550
KVPDVLPVLP DLPLPAIQAN YRPLPSLELI SSFQPKRKAF SSPQEEEEAG
560 570 580 590 600
FTGRRMNSKM QVYSGSKCAY LPKMMTLHQQ CIRVLKNNID SIFEVGGVPY
610 620 630 640 650
SVLEPVLERC TPDQLYRIEE YNHVLIEETD QLWKVHCHRD FKEERPEEYE
660 670 680 690 700
SWREMYLRLQ DAREQRLRVL TKNIQFAHAN KPKGRQAKMA FVNSVAKPPR
710 720 730 740 750
DVRRRQEKFG TGGAAVPEKI KIKPAPYPMG SSHASASSIS FNPSPEEPAY
760 770 780 790
DGPSTSSAHL APVVSSTVSY DPRKPTVKKI APMMAKTIKA FKNRFSRR
Length:798
Mass (Da):89,909
Last modified:April 20, 2010 - v2
Checksum:i2C8FD8710E27EE46
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A024RAC6A0A024RAC6_HUMAN
Elongin-A
ELOA TCEB3, hCG_37551
772Annotation score:

Sequence cautioni

The sequence AAA75492 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAH02883 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAO15305 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAG35905 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence EAW95070 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_020104145T → M. Corresponds to variant dbSNP:rs2235541Ensembl.1
Natural variantiVAR_033850324V → I. Corresponds to variant dbSNP:rs520713Ensembl.1
Natural variantiVAR_033851516A → V. Corresponds to variant dbSNP:rs550252Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK313079 mRNA Translation: BAG35905.1 Different initiation.
DA333869 mRNA No translation available.
AL031295 Genomic DNA No translation available.
CH471134 Genomic DNA Translation: EAW95070.1 Different initiation.
L47345 mRNA Translation: AAA75492.1 Different initiation.
BC002883 mRNA Translation: AAH02883.1 Different initiation.
AF116729 mRNA Translation: AAO15305.1 Different initiation.
CCDSiCCDS239.2
PIRiJC4636
RefSeqiNP_003189.2, NM_003198.2
UniGeneiHs.15535

Genome annotation databases

EnsembliENST00000418390; ENSP00000395574; ENSG00000011007
ENST00000613537; ENSP00000484196; ENSG00000011007
GeneIDi6924
KEGGihsa:6924
UCSCiuc001bho.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK313079 mRNA Translation: BAG35905.1 Different initiation.
DA333869 mRNA No translation available.
AL031295 Genomic DNA No translation available.
CH471134 Genomic DNA Translation: EAW95070.1 Different initiation.
L47345 mRNA Translation: AAA75492.1 Different initiation.
BC002883 mRNA Translation: AAH02883.1 Different initiation.
AF116729 mRNA Translation: AAO15305.1 Different initiation.
CCDSiCCDS239.2
PIRiJC4636
RefSeqiNP_003189.2, NM_003198.2
UniGeneiHs.15535

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4HFXX-ray2.54A/B/C/D597-682[»]
ProteinModelPortaliQ14241
SMRiQ14241
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112786, 59 interactors
IntActiQ14241, 56 interactors
MINTiQ14241
STRINGi9606.ENSP00000395574

PTM databases

iPTMnetiQ14241
PhosphoSitePlusiQ14241

Polymorphism and mutation databases

BioMutaiTCEB3
DMDMi294862430

Proteomic databases

EPDiQ14241
MaxQBiQ14241
PaxDbiQ14241
PeptideAtlasiQ14241
PRIDEiQ14241
ProteomicsDBi59938

Protocols and materials databases

DNASUi6924
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000418390; ENSP00000395574; ENSG00000011007
ENST00000613537; ENSP00000484196; ENSG00000011007
GeneIDi6924
KEGGihsa:6924
UCSCiuc001bho.4 human

Organism-specific databases

CTDi6924
DisGeNETi6924
EuPathDBiHostDB:ENSG00000011007.12
GeneCardsiELOA
H-InvDBiHIX0000251
HGNCiHGNC:11620 ELOA
HPAiHPA005910
MIMi600786 gene
neXtProtiNX_Q14241
OpenTargetsiENSG00000011007
PharmGKBiPA36379
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2821 Eukaryota
ENOG4110PG3 LUCA
GeneTreeiENSGT00390000002428
HOGENOMiHOG000059565
HOVERGENiHBG051467
InParanoidiQ14241
KOiK15076
OMAiHLQETGI
OrthoDBiEOG091G0D2G
PhylomeDBiQ14241
TreeFamiTF317259

Enzyme and pathway databases

ReactomeiR-HSA-112382 Formation of RNA Pol II elongation complex
R-HSA-167152 Formation of HIV elongation complex in the absence of HIV Tat
R-HSA-167200 Formation of HIV-1 elongation complex containing HIV-1 Tat
R-HSA-167238 Pausing and recovery of Tat-mediated HIV elongation
R-HSA-167243 Tat-mediated HIV elongation arrest and recovery
R-HSA-167246 Tat-mediated elongation of the HIV-1 transcript
R-HSA-167287 HIV elongation arrest and recovery
R-HSA-167290 Pausing and recovery of HIV elongation
R-HSA-674695 RNA Polymerase II Pre-transcription Events
R-HSA-6796648 TP53 Regulates Transcription of DNA Repair Genes
R-HSA-75955 RNA Polymerase II Transcription Elongation

Miscellaneous databases

GeneWikiiTCEB3
GenomeRNAii6924
PROiPR:Q14241
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000011007 Expressed in 240 organ(s), highest expression level in upper lobe of lung
ExpressionAtlasiQ14241 baseline and differential
GenevisibleiQ14241 HS

Family and domain databases

Gene3Di1.20.930.10, 1 hit
InterProiView protein in InterPro
IPR001810 F-box_dom
IPR010684 RNA_pol_II_trans_fac_SIII_A
IPR003617 TFIIS/CRSP70_N_sub
IPR035441 TFIIS/LEDGF_dom_sf
IPR017923 TFIIS_N
PfamiView protein in Pfam
PF06881 Elongin_A, 1 hit
PF08711 Med26, 1 hit
SMARTiView protein in SMART
SM00509 TFS2N, 1 hit
SUPFAMiSSF47676 SSF47676, 1 hit
PROSITEiView protein in PROSITE
PS50181 FBOX, 1 hit
PS51319 TFIIS_N, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiELOA1_HUMAN
AccessioniPrimary (citable) accession number: Q14241
Secondary accession number(s): B2R7Q8, Q8IXH1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2003
Last sequence update: April 20, 2010
Last modified: November 7, 2018
This is version 176 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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