UniProtKB - Q14241 (ELOA1_HUMAN)
Elongin-A
ELOA
Functioni
SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex).
1 PublicationCaution
GO - Biological processi
- regulation of transcription by RNA polymerase II Source: ProtInc
- transcription elongation from RNA polymerase II promoter Source: InterPro
- transcription initiation from RNA polymerase II promoter Source: UniProtKB
Keywordsi
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | Q14241 |
Reactomei | R-HSA-112382, Formation of RNA Pol II elongation complex R-HSA-167152, Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167200, Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167238, Pausing and recovery of Tat-mediated HIV elongation R-HSA-167243, Tat-mediated HIV elongation arrest and recovery R-HSA-167246, Tat-mediated elongation of the HIV-1 transcript R-HSA-167287, HIV elongation arrest and recovery R-HSA-167290, Pausing and recovery of HIV elongation R-HSA-674695, RNA Polymerase II Pre-transcription Events R-HSA-6796648, TP53 Regulates Transcription of DNA Repair Genes R-HSA-75955, RNA Polymerase II Transcription Elongation |
SignaLinki | Q14241 |
Names & Taxonomyi
Protein namesi | Recommended name: Elongin-AShort name: EloA Alternative name(s): Elongin 110 kDa subunit RNA polymerase II transcription factor SIII subunit A1 SIII p110 Transcription elongation factor B polypeptide 3 |
Gene namesi | ORF Names:MSTP059 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:11620, ELOA |
MIMi | 600786, gene |
neXtProti | NX_Q14241 |
VEuPathDBi | HostDB:ENSG00000011007 |
Subcellular locationi
Nucleus
- Nucleus Curated
Extracellular region or secreted
- extracellular space Source: UniProtKB
Nucleus
- elongin complex Source: UniProtKB
- nucleoplasm Source: Reactome
Other locations
- site of DNA damage Source: UniProtKB
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 6924 |
OpenTargetsi | ENSG00000011007 |
PharmGKBi | PA36379 |
Miscellaneous databases
Pharosi | Q14241, Tbio |
Genetic variation databases
BioMutai | ELOA |
DMDMi | 294862430 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000086960 | 1 – 798 | Elongin-AAdd BLAST | 798 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 222 | PhosphoserineBy similarity | 1 | |
Modified residuei | 410 | PhosphoserineCombined sources | 1 | |
Modified residuei | 413 | PhosphoserineCombined sources | 1 | |
Modified residuei | 420 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 460 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 542 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | Q14241 |
jPOSTi | Q14241 |
MassIVEi | Q14241 |
MaxQBi | Q14241 |
PaxDbi | Q14241 |
PeptideAtlasi | Q14241 |
PRIDEi | Q14241 |
ProteomicsDBi | 59938 |
PTM databases
GlyGeni | Q14241, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q14241 |
PhosphoSitePlusi | Q14241 |
Expressioni
Gene expression databases
Bgeei | ENSG00000011007, Expressed in stomach and 253 other tissues |
ExpressionAtlasi | Q14241, baseline and differential |
Genevisiblei | Q14241, HS |
Organism-specific databases
HPAi | ENSG00000011007, Low tissue specificity |
Interactioni
Subunit structurei
Heterotrimer of an A (ELOA, ELOA2 or ELOA3P), ELOB and ELOC subunit (By similarity).
Interacts with ERCC6; the interaction is induced by DNA damaging agents or inhibitors of RNA polymerase II elongation (By similarity).
Interacts (via BC-box) with CUL5 (By similarity).
By similarityBinary interactionsi
Q14241
Protein-protein interaction databases
BioGRIDi | 112786, 178 interactors |
IntActi | Q14241, 68 interactors |
MINTi | Q14241 |
STRINGi | 9606.ENSP00000395574 |
Miscellaneous databases
RNActi | Q14241, protein |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | Q14241 |
SMRi | Q14241 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 30 – 105 | TFIIS N-terminalPROSITE-ProRule annotationAdd BLAST | 76 | |
Domaini | 592 – 636 | F-boxPROSITE-ProRule annotationAdd BLAST | 45 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 25 | DisorderedSequence analysisAdd BLAST | 25 | |
Regioni | 103 – 429 | DisorderedSequence analysisAdd BLAST | 327 | |
Regioni | 444 – 492 | DisorderedSequence analysisAdd BLAST | 49 | |
Regioni | 548 – 707 | Activation domainBy similarityAdd BLAST | 160 | |
Regioni | 576 – 585 | BC-boxBy similarity | 10 | |
Regioni | 700 – 758 | DisorderedSequence analysisAdd BLAST | 59 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 104 – 139 | Basic and acidic residuesSequence analysisAdd BLAST | 36 | |
Compositional biasi | 157 – 189 | Basic and acidic residuesSequence analysisAdd BLAST | 33 | |
Compositional biasi | 190 – 212 | Polar residuesSequence analysisAdd BLAST | 23 | |
Compositional biasi | 218 – 233 | Basic and acidic residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 251 – 337 | Basic and acidic residuesSequence analysisAdd BLAST | 87 | |
Compositional biasi | 348 – 372 | Basic and acidic residuesSequence analysisAdd BLAST | 25 | |
Compositional biasi | 392 – 419 | Basic and acidic residuesSequence analysisAdd BLAST | 28 |
Domaini
Phylogenomic databases
eggNOGi | KOG2821, Eukaryota |
GeneTreei | ENSGT00390000002428 |
InParanoidi | Q14241 |
OMAi | MYIDHYR |
OrthoDBi | 1174517at2759 |
PhylomeDBi | Q14241 |
TreeFami | TF317259 |
Family and domain databases
Gene3Di | 1.20.930.10, 1 hit |
InterProi | View protein in InterPro IPR001810, F-box_dom IPR010684, RNA_pol_II_trans_fac_SIII_A IPR003617, TFIIS/CRSP70_N_sub IPR035441, TFIIS/LEDGF_dom_sf IPR017923, TFIIS_N |
Pfami | View protein in Pfam PF06881, Elongin_A, 1 hit PF08711, Med26, 1 hit |
SMARTi | View protein in SMART SM00509, TFS2N, 1 hit |
SUPFAMi | SSF47676, SSF47676, 1 hit |
PROSITEi | View protein in PROSITE PS50181, FBOX, 1 hit PS51319, TFIIS_N, 1 hit |
i Sequence
Sequence statusi: Complete.
10 20 30 40 50
MHGGRSCGPR TRREPSSGEE AAPVTAMAAE SALQVVEKLQ ARLAANPDPK
60 70 80 90 100
KLLKYLKKLS TLPITVDILA ETGVGKTVNS LRKHEHVGSF ARDLVAQWKK
110 120 130 140 150
LVPVERNAEP DEQDFEKSNS RKRPRDALQK EEEMEGDYQE TWKATGSRSY
160 170 180 190 200
SPDHRQKKHR KLSELERPHK VSHGHERRDE RKRCHRMSPT YSSDPESSDY
210 220 230 240 250
GHVQSPPSCT SPHQMYVDHY RSLEEDQEPI VSHQKPGKGH SNAFQDRLGA
260 270 280 290 300
SQERHLGEPH GKGVVSQNKE HKSSHKDKRP VDAKSDEKAS VVSREKSHKA
310 320 330 340 350
LSKEENRRPP SGDNAREKPP SSGVKKEKDR EGSSLKKKCL PPSEAASDNH
360 370 380 390 400
LKKPKHRDPE KAKLDKSKQG LDSFDTGKGA GDLLPKVKEK GSNNLKTPEG
410 420 430 440 450
KVKTNLDRKS LGSLPKVEET DMEDEFEQPT MSFESYLSYD QPRKKKKKIV
460 470 480 490 500
KTSATALGDK GLKKNDSKST GKNLDSVQKL PKVNKTKSEK PAGADLAKLR
510 520 530 540 550
KVPDVLPVLP DLPLPAIQAN YRPLPSLELI SSFQPKRKAF SSPQEEEEAG
560 570 580 590 600
FTGRRMNSKM QVYSGSKCAY LPKMMTLHQQ CIRVLKNNID SIFEVGGVPY
610 620 630 640 650
SVLEPVLERC TPDQLYRIEE YNHVLIEETD QLWKVHCHRD FKEERPEEYE
660 670 680 690 700
SWREMYLRLQ DAREQRLRVL TKNIQFAHAN KPKGRQAKMA FVNSVAKPPR
710 720 730 740 750
DVRRRQEKFG TGGAAVPEKI KIKPAPYPMG SSHASASSIS FNPSPEEPAY
760 770 780 790
DGPSTSSAHL APVVSSTVSY DPRKPTVKKI APMMAKTIKA FKNRFSRR
Sequence cautioni
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_020104 | 145 | T → M. Corresponds to variant dbSNP:rs2235541Ensembl. | 1 | |
Natural variantiVAR_033850 | 324 | V → I. Corresponds to variant dbSNP:rs520713Ensembl. | 1 | |
Natural variantiVAR_033851 | 516 | A → V. Corresponds to variant dbSNP:rs550252Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK313079 mRNA Translation: BAG35905.1 Different initiation. DA333869 mRNA No translation available. AL031295 Genomic DNA No translation available. CH471134 Genomic DNA Translation: EAW95070.1 Different initiation. L47345 mRNA Translation: AAA75492.1 Different initiation. BC002883 mRNA Translation: AAH02883.1 Different initiation. AF116729 mRNA Translation: AAO15305.1 Different initiation. |
PIRi | JC4636 |
RefSeqi | NP_003189.2, NM_003198.2 |
Genome annotation databases
Ensembli | ENST00000418390.7; ENSP00000395574.3; ENSG00000011007.13 ENST00000613537.5; ENSP00000484196.2; ENSG00000011007.13 |
GeneIDi | 6924 |
KEGGi | hsa:6924 |
UCSCi | uc001bho.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK313079 mRNA Translation: BAG35905.1 Different initiation. DA333869 mRNA No translation available. AL031295 Genomic DNA No translation available. CH471134 Genomic DNA Translation: EAW95070.1 Different initiation. L47345 mRNA Translation: AAA75492.1 Different initiation. BC002883 mRNA Translation: AAH02883.1 Different initiation. AF116729 mRNA Translation: AAO15305.1 Different initiation. |
PIRi | JC4636 |
RefSeqi | NP_003189.2, NM_003198.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4HFX | X-ray | 2.54 | A/B/C/D | 597-682 | [»] | |
6ZUZ | NMR | - | A | 26-108 | [»] | |
AlphaFoldDBi | Q14241 | |||||
SMRi | Q14241 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 112786, 178 interactors |
IntActi | Q14241, 68 interactors |
MINTi | Q14241 |
STRINGi | 9606.ENSP00000395574 |
PTM databases
GlyGeni | Q14241, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q14241 |
PhosphoSitePlusi | Q14241 |
Genetic variation databases
BioMutai | ELOA |
DMDMi | 294862430 |
Proteomic databases
EPDi | Q14241 |
jPOSTi | Q14241 |
MassIVEi | Q14241 |
MaxQBi | Q14241 |
PaxDbi | Q14241 |
PeptideAtlasi | Q14241 |
PRIDEi | Q14241 |
ProteomicsDBi | 59938 |
Protocols and materials databases
Antibodypediai | 1742, 378 antibodies from 32 providers |
DNASUi | 6924 |
Genome annotation databases
Ensembli | ENST00000418390.7; ENSP00000395574.3; ENSG00000011007.13 ENST00000613537.5; ENSP00000484196.2; ENSG00000011007.13 |
GeneIDi | 6924 |
KEGGi | hsa:6924 |
UCSCi | uc001bho.4, human |
Organism-specific databases
CTDi | 6924 |
DisGeNETi | 6924 |
GeneCardsi | ELOA |
HGNCi | HGNC:11620, ELOA |
HPAi | ENSG00000011007, Low tissue specificity |
MIMi | 600786, gene |
neXtProti | NX_Q14241 |
OpenTargetsi | ENSG00000011007 |
PharmGKBi | PA36379 |
VEuPathDBi | HostDB:ENSG00000011007 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2821, Eukaryota |
GeneTreei | ENSGT00390000002428 |
InParanoidi | Q14241 |
OMAi | MYIDHYR |
OrthoDBi | 1174517at2759 |
PhylomeDBi | Q14241 |
TreeFami | TF317259 |
Enzyme and pathway databases
PathwayCommonsi | Q14241 |
Reactomei | R-HSA-112382, Formation of RNA Pol II elongation complex R-HSA-167152, Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167200, Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167238, Pausing and recovery of Tat-mediated HIV elongation R-HSA-167243, Tat-mediated HIV elongation arrest and recovery R-HSA-167246, Tat-mediated elongation of the HIV-1 transcript R-HSA-167287, HIV elongation arrest and recovery R-HSA-167290, Pausing and recovery of HIV elongation R-HSA-674695, RNA Polymerase II Pre-transcription Events R-HSA-6796648, TP53 Regulates Transcription of DNA Repair Genes R-HSA-75955, RNA Polymerase II Transcription Elongation |
SignaLinki | Q14241 |
Miscellaneous databases
BioGRID-ORCSi | 6924, 58 hits in 1127 CRISPR screens |
ChiTaRSi | TCEB3, human |
GeneWikii | TCEB3 |
GenomeRNAii | 6924 |
Pharosi | Q14241, Tbio |
PROi | PR:Q14241 |
RNActi | Q14241, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000011007, Expressed in stomach and 253 other tissues |
ExpressionAtlasi | Q14241, baseline and differential |
Genevisiblei | Q14241, HS |
Family and domain databases
Gene3Di | 1.20.930.10, 1 hit |
InterProi | View protein in InterPro IPR001810, F-box_dom IPR010684, RNA_pol_II_trans_fac_SIII_A IPR003617, TFIIS/CRSP70_N_sub IPR035441, TFIIS/LEDGF_dom_sf IPR017923, TFIIS_N |
Pfami | View protein in Pfam PF06881, Elongin_A, 1 hit PF08711, Med26, 1 hit |
SMARTi | View protein in SMART SM00509, TFS2N, 1 hit |
SUPFAMi | SSF47676, SSF47676, 1 hit |
PROSITEi | View protein in PROSITE PS50181, FBOX, 1 hit PS51319, TFIIS_N, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ELOA1_HUMAN | |
Accessioni | Q14241Primary (citable) accession number: Q14241 Secondary accession number(s): B2R7Q8, Q8IXH1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 11, 2003 |
Last sequence update: | April 20, 2010 | |
Last modified: | May 25, 2022 | |
This is version 196 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references