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UniProtKB - Q14241 (ELOA1_HUMAN)

Entry version 191 (10 Feb 2021)
Sequence version 2 (20 Apr 2010)
Previous versions | rss
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Protein

Elongin-A

Gene

ELOA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex).1 Publication

Caution

It is uncertain whether Met-1 or Met-27 is the initiator.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q14241

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-112382, Formation of RNA Pol II elongation complex
R-HSA-167152, Formation of HIV elongation complex in the absence of HIV Tat
R-HSA-167200, Formation of HIV-1 elongation complex containing HIV-1 Tat
R-HSA-167238, Pausing and recovery of Tat-mediated HIV elongation
R-HSA-167243, Tat-mediated HIV elongation arrest and recovery
R-HSA-167246, Tat-mediated elongation of the HIV-1 transcript
R-HSA-167287, HIV elongation arrest and recovery
R-HSA-167290, Pausing and recovery of HIV elongation
R-HSA-674695, RNA Polymerase II Pre-transcription Events
R-HSA-6796648, TP53 Regulates Transcription of DNA Repair Genes
R-HSA-75955, RNA Polymerase II Transcription Elongation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Elongin-A
Short name:
EloA
Alternative name(s):
Elongin 110 kDa subunit
RNA polymerase II transcription factor SIII subunit A1
SIII p110
Transcription elongation factor B polypeptide 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ELOAImported
Synonyms:TCEB3
ORF Names:MSTP059
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:11620, ELOA

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		600786, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q14241

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000011007.12

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		6924

Open Targets

More...OpenTargetsi		ENSG00000011007

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA36379

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q14241, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ELOA

Domain mapping of disease mutations (DMDM)

More...DMDMi		294862430

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000869601 – 798Elongin-AAdd BLAST798

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei222PhosphoserineBy similarity1
Modified residuei410PhosphoserineCombined sources1
Modified residuei413PhosphoserineCombined sources1
Modified residuei420PhosphothreonineCombined sources1
Modified residuei460N6-acetyllysineBy similarity1
Modified residuei542PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q14241

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q14241

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q14241

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q14241

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q14241

PeptideAtlas

More...PeptideAtlasi		Q14241

PRoteomics IDEntifications database

More...PRIDEi		Q14241

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		59938

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q14241

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q14241

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000011007, Expressed in stomach and 252 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q14241, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q14241, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000011007, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterotrimer of an A (ELOA, ELOA2 or ELOA3P), ELOB and ELOC subunit (By similarity).

Interacts with ERCC6; the interaction is induced by DNA damaging agents or inhibitors of RNA polymerase II elongation (By similarity).

Interacts (via BC-box) with CUL5 (By similarity).

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details
Q14241
With#Exp.IntAct
AXIN2 [Q9Y2T1]3EBI-742350,EBI-4400025
BACH2 [Q9BYV9]3EBI-742350,EBI-1642333
CBY2 [Q8NA61]3EBI-742350,EBI-741724
CCDC57 - isoform 2 [Q2TAC2-2]3EBI-742350,EBI-10961624
CDR2L [Q86X02]3EBI-742350,EBI-11063830
CEP57L1 - isoform 2 [Q8IYX8-2]3EBI-742350,EBI-10181988
CEP70 [Q8NHQ1]3EBI-742350,EBI-739624
CNTROB [Q8N137]3EBI-742350,EBI-947360
EVI5 [O60447]3EBI-742350,EBI-852291
FAM9B [Q8IZU0]3EBI-742350,EBI-10175124
FCHO1 [A0A0C3SFZ9]3EBI-742350,EBI-11977403
FLJ13057 [Q53SE7]3EBI-742350,EBI-10172181
FXR1 - isoform 2 [P51114-2]3EBI-742350,EBI-11022345
GMCL1 [Q96IK5]3EBI-742350,EBI-2548508
GOLGA6A [Q9NYA3]3EBI-742350,EBI-11163335
GRIPAP1 [Q4V328]3EBI-742350,EBI-717919
HOMEZ - isoform 2 [Q8IX15-3]3EBI-742350,EBI-10172004
JAKMIP2 [Q96AA8]3EBI-742350,EBI-752007
KANK2 [Q63ZY3]3EBI-742350,EBI-2556193
KLHL2 [O95198]3EBI-742350,EBI-746999
KRT40 [Q6A162]3EBI-742350,EBI-10171697
KXD1 [Q9BQD3]3EBI-742350,EBI-739657
LZTS1 [Q9Y250]3EBI-742350,EBI-1216080
MCC [P23508]3EBI-742350,EBI-307531
MDFI [Q99750]6EBI-742350,EBI-724076
MID1 [O15344]3EBI-742350,EBI-2340316
MID2 - isoform 2 [Q9UJV3-2]3EBI-742350,EBI-10172526
NAB2 [Q15742]3EBI-742350,EBI-8641936
NACC1 [Q96RE7]3EBI-742350,EBI-7950997
NAF1 [Q96HR8]3EBI-742350,EBI-2515597
NFKBID [Q8NI38]3EBI-742350,EBI-10271199
PER2 [O15055]3EBI-742350,EBI-1054296
PLK4 [O00444]6EBI-742350,EBI-746202
PPFIA1 [Q13136]3EBI-742350,EBI-745426
PRDM6 [Q9NQX0]3EBI-742350,EBI-11320284
PRMT5 [O14744]3EBI-742350,EBI-351098
RABEP1 [Q15276]3EBI-742350,EBI-447043
SPECC1L [Q69YQ0]3EBI-742350,EBI-351113
TNIP1 [Q15025]3EBI-742350,EBI-357849
TP53BP2 [Q05BL1]3EBI-742350,EBI-11952721
TRIM37 [O94972]3EBI-742350,EBI-741602
TRIM54 [Q9BYV2]3EBI-742350,EBI-2130429
ZNF792 [Q3KQV3]3EBI-742350,EBI-10240849

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		112786, 113 interactors

Protein interaction database and analysis system

More...IntActi		Q14241, 64 interactors

Molecular INTeraction database

More...MINTi		Q14241

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000395574

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q14241, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1798
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q14241

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini30 – 105TFIIS N-terminalPROSITE-ProRule annotationAdd BLAST76
Domaini592 – 636F-boxPROSITE-ProRule annotationAdd BLAST45

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni548 – 707Activation domainBy similarityAdd BLAST160
Regioni576 – 585BC-boxBy similarity10

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The BC-box, which mediates binding to the elongin BC complex, has the consensus sequence [APST]-L-x3-C-x3-[AILV].By similarity

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2821, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000002428

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q14241

Identification of Orthologs from Complete Genome Data

More...OMAi		SNQCFTE

Database of Orthologous Groups

More...OrthoDBi		1174517at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q14241

TreeFam database of animal gene trees

More...TreeFami		TF317259

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.20.930.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001810, F-box_dom
IPR010684, RNA_pol_II_trans_fac_SIII_A
IPR003617, TFIIS/CRSP70_N_sub
IPR035441, TFIIS/LEDGF_dom_sf
IPR017923, TFIIS_N

Pfam protein domain database

More...Pfami		View protein in Pfam
PF06881, Elongin_A, 1 hit
PF08711, Med26, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00509, TFS2N, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47676, SSF47676, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50181, FBOX, 1 hit
PS51319, TFIIS_N, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q14241-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MHGGRSCGPR TRREPSSGEE AAPVTAMAAE SALQVVEKLQ ARLAANPDPK 
        60         70         80         90        100
KLLKYLKKLS TLPITVDILA ETGVGKTVNS LRKHEHVGSF ARDLVAQWKK 
       110        120        130        140        150
LVPVERNAEP DEQDFEKSNS RKRPRDALQK EEEMEGDYQE TWKATGSRSY 
       160        170        180        190        200
SPDHRQKKHR KLSELERPHK VSHGHERRDE RKRCHRMSPT YSSDPESSDY 
       210        220        230        240        250
GHVQSPPSCT SPHQMYVDHY RSLEEDQEPI VSHQKPGKGH SNAFQDRLGA 
       260        270        280        290        300
SQERHLGEPH GKGVVSQNKE HKSSHKDKRP VDAKSDEKAS VVSREKSHKA 
       310        320        330        340        350
LSKEENRRPP SGDNAREKPP SSGVKKEKDR EGSSLKKKCL PPSEAASDNH 
       360        370        380        390        400
LKKPKHRDPE KAKLDKSKQG LDSFDTGKGA GDLLPKVKEK GSNNLKTPEG 
       410        420        430        440        450
KVKTNLDRKS LGSLPKVEET DMEDEFEQPT MSFESYLSYD QPRKKKKKIV 
       460        470        480        490        500
KTSATALGDK GLKKNDSKST GKNLDSVQKL PKVNKTKSEK PAGADLAKLR 
       510        520        530        540        550
KVPDVLPVLP DLPLPAIQAN YRPLPSLELI SSFQPKRKAF SSPQEEEEAG 
       560        570        580        590        600
FTGRRMNSKM QVYSGSKCAY LPKMMTLHQQ CIRVLKNNID SIFEVGGVPY 
       610        620        630        640        650
SVLEPVLERC TPDQLYRIEE YNHVLIEETD QLWKVHCHRD FKEERPEEYE 
       660        670        680        690        700
SWREMYLRLQ DAREQRLRVL TKNIQFAHAN KPKGRQAKMA FVNSVAKPPR 
       710        720        730        740        750
DVRRRQEKFG TGGAAVPEKI KIKPAPYPMG SSHASASSIS FNPSPEEPAY 
       760        770        780        790 
DGPSTSSAHL APVVSSTVSY DPRKPTVKKI APMMAKTIKA FKNRFSRR
Length:798
Mass (Da):89,909
Last modified:April 20, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2C8FD8710E27EE46
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A024RAC6A0A024RAC6_HUMAN
Elongin-A
ELOA TCEB3, hCG_37551
772Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA75492 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAH02883 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAO15305 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAG35905 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence EAW95070 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_020104145T → M. Corresponds to variant dbSNP:rs2235541Ensembl.1
Natural variantiVAR_033850324V → I. Corresponds to variant dbSNP:rs520713Ensembl.1
Natural variantiVAR_033851516A → V. Corresponds to variant dbSNP:rs550252Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK313079 mRNA Translation: BAG35905.1 Different initiation.
DA333869 mRNA No translation available.
AL031295 Genomic DNA No translation available.
CH471134 Genomic DNA Translation: EAW95070.1 Different initiation.
L47345 mRNA Translation: AAA75492.1 Different initiation.
BC002883 mRNA Translation: AAH02883.1 Different initiation.
AF116729 mRNA Translation: AAO15305.1 Different initiation.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS239.2

Protein sequence database of the Protein Information Resource

More...PIRi		JC4636

NCBI Reference Sequences

More...RefSeqi		NP_003189.2, NM_003198.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000418390; ENSP00000395574; ENSG00000011007
ENST00000613537; ENSP00000484196; ENSG00000011007

Database of genes from NCBI RefSeq genomes

More...GeneIDi		6924

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:6924

UCSC genome browser

More...UCSCi		uc001bho.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK313079 mRNA Translation: BAG35905.1 Different initiation.
DA333869 mRNA No translation available.
AL031295 Genomic DNA No translation available.
CH471134 Genomic DNA Translation: EAW95070.1 Different initiation.
L47345 mRNA Translation: AAA75492.1 Different initiation.
BC002883 mRNA Translation: AAH02883.1 Different initiation.
AF116729 mRNA Translation: AAO15305.1 Different initiation.
CCDSiCCDS239.2
PIRiJC4636
RefSeqiNP_003189.2, NM_003198.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4HFXX-ray2.54A/B/C/D597-682[»]
SMRiQ14241
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi112786, 113 interactors
IntActiQ14241, 64 interactors
MINTiQ14241
STRINGi9606.ENSP00000395574

PTM databases

iPTMnetiQ14241
PhosphoSitePlusiQ14241

Genetic variation databases

BioMutaiELOA
DMDMi294862430

Proteomic databases

EPDiQ14241
jPOSTiQ14241
MassIVEiQ14241
MaxQBiQ14241
PaxDbiQ14241
PeptideAtlasiQ14241
PRIDEiQ14241
ProteomicsDBi59938

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		1742, 359 antibodies

The DNASU plasmid repository

More...DNASUi		6924

Genome annotation databases

EnsembliENST00000418390; ENSP00000395574; ENSG00000011007
ENST00000613537; ENSP00000484196; ENSG00000011007
GeneIDi6924
KEGGihsa:6924
UCSCiuc001bho.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		6924
DisGeNETi6924

GeneCards: human genes, protein and diseases

More...GeneCardsi		ELOA
HGNCiHGNC:11620, ELOA
HPAiENSG00000011007, Low tissue specificity
MIMi600786, gene
neXtProtiNX_Q14241
OpenTargetsiENSG00000011007
PharmGKBiPA36379
VEuPathDBiHostDB:ENSG00000011007.12

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG2821, Eukaryota
GeneTreeiENSGT00390000002428
InParanoidiQ14241
OMAiSNQCFTE
OrthoDBi1174517at2759
PhylomeDBiQ14241
TreeFamiTF317259

Enzyme and pathway databases

PathwayCommonsiQ14241
ReactomeiR-HSA-112382, Formation of RNA Pol II elongation complex
R-HSA-167152, Formation of HIV elongation complex in the absence of HIV Tat
R-HSA-167200, Formation of HIV-1 elongation complex containing HIV-1 Tat
R-HSA-167238, Pausing and recovery of Tat-mediated HIV elongation
R-HSA-167243, Tat-mediated HIV elongation arrest and recovery
R-HSA-167246, Tat-mediated elongation of the HIV-1 transcript
R-HSA-167287, HIV elongation arrest and recovery
R-HSA-167290, Pausing and recovery of HIV elongation
R-HSA-674695, RNA Polymerase II Pre-transcription Events
R-HSA-6796648, TP53 Regulates Transcription of DNA Repair Genes
R-HSA-75955, RNA Polymerase II Transcription Elongation

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		6924, 39 hits in 888 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		TCEB3, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		TCEB3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		6924
PharosiQ14241, Tbio

Protein Ontology

More...PROi		PR:Q14241
RNActiQ14241, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000011007, Expressed in stomach and 252 other tissues
ExpressionAtlasiQ14241, baseline and differential
GenevisibleiQ14241, HS

Family and domain databases

Gene3Di1.20.930.10, 1 hit
InterProiView protein in InterPro
IPR001810, F-box_dom
IPR010684, RNA_pol_II_trans_fac_SIII_A
IPR003617, TFIIS/CRSP70_N_sub
IPR035441, TFIIS/LEDGF_dom_sf
IPR017923, TFIIS_N
PfamiView protein in Pfam
PF06881, Elongin_A, 1 hit
PF08711, Med26, 1 hit
SMARTiView protein in SMART
SM00509, TFS2N, 1 hit
SUPFAMiSSF47676, SSF47676, 1 hit
PROSITEiView protein in PROSITE
PS50181, FBOX, 1 hit
PS51319, TFIIS_N, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiELOA1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q14241
Secondary accession number(s): B2R7Q8, Q8IXH1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2003
Last sequence update: April 20, 2010
Last modified: February 10, 2021
This is version 191 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human variants curated from literature reports
    Index of human variants curated from literature reports
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  5. Human entries with genetic variants
    List of human entries with genetic variants
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