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Protein

Protein NPAT

Gene

NPAT

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for progression through the G1 and S phases of the cell cycle and for S phase entry. Activates transcription of the histone H2A, histone H2B, histone H3 and histone H4 genes in conjunction with MIZF. Also positively regulates the ATM, MIZF and PRKDC promoters. Transcriptional activation may be accomplished at least in part by the recruitment of the NuA4 histone acetyltransferase (HAT) complex to target gene promoters.14 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • protein C-terminus binding Source: UniProtKB
  • protein N-terminus binding Source: UniProtKB
  • transcription coactivator activity Source: UniProtKB
  • transcription corepressor activity Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator
Biological processCell cycle, Transcription, Transcription regulation

Enzyme and pathway databases

SIGNOR Signaling Network Open Resource

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SIGNORi
Q14207

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein NPAT
Alternative name(s):
Nuclear protein of the ataxia telangiectasia mutated locus
Short name:
Nuclear protein of the ATM locus
p220
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NPAT
Synonyms:CAND3, E14
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000149308.16

Human Gene Nomenclature Database

More...
HGNCi
HGNC:7896 NPAT

Online Mendelian Inheritance in Man (OMIM)

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MIMi
601448 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q14207

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi7V → A: Impairs activation of histone gene transcription; when associated with A-10; A-11; A-15 and A-18. 1 Publication1
Mutagenesisi10L → A: Impairs activation of histone gene transcription; when associated with A-7; A-11; A-15 and A-18. 1 Publication1
Mutagenesisi11V → A: Impairs activation of histone gene transcription; when associated with A-7; A-10; A-15 and A-18. 1 Publication1
Mutagenesisi15L → A: Impairs activation of histone gene transcription; when associated with A-7; A-10; A-11 and A-18. 1 Publication1
Mutagenesisi18E → A: Impairs activation of histone gene transcription; when associated with A-7; A-10; A-11 and A-15. 1 Publication1
Mutagenesisi27F → A: Impairs activation of histone gene transcription; when associated with A-30. 1 Publication1
Mutagenesisi30E → A: Impairs activation of histone gene transcription; when associated with A-27. 1 Publication1
Mutagenesisi331 – 333LFD → AAA: Impairs activation of histone gene transcription. Impairs interaction with BZW1, RUVBL1, RUVBL2 and TRRAP. 1 Publication3
Mutagenesisi775S → A: Impairs activation of histone gene transcription; when associated with A-779; A-1100; A-1270 and A-1350. 4 Publications1
Mutagenesisi779S → A: Impairs activation of histone gene transcription; when associated with A-775; A-1100; A-1270 and A-1350. 4 Publications1
Mutagenesisi1100S → A: Impairs activation of histone gene transcription; when associated with A-775; A-779; A-1270 and A-1350. 4 Publications1
Mutagenesisi1270T → A: Impairs activation of histone gene transcription; when associated with A-775; A-779; A-1100 and A-1350. 4 Publications1
Mutagenesisi1350T → A: Impairs activation of histone gene transcription; when associated with A-775; A-779; A-1100 and A-1270. 4 Publications1

Organism-specific databases

DisGeNET

More...
DisGeNETi
4863

Open Targets

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OpenTargetsi
ENSG00000149308

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA31697

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
NPAT

Domain mapping of disease mutations (DMDM)

More...
DMDMi
296439285

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003181631 – 1427Protein NPATAdd BLAST1427

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei207PhosphoserineCombined sources1
Modified residuei554PhosphoserineCombined sources1
Modified residuei599PhosphoserineBy similarity1
Modified residuei775Phosphoserine; by CDK21 Publication1
Modified residuei779Phosphoserine; by CDK21 Publication1
Modified residuei1100Phosphoserine; by CDK21 Publication1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki1116Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1149Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei1151PhosphoserineCombined sources1
Modified residuei1200PhosphoserineCombined sources1
Modified residuei1228N6-acetyllysineCombined sources1
Modified residuei1254PhosphoserineBy similarity1
Modified residuei1270Phosphothreonine; by CDK21 Publication1
Cross-linki1280Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei1350Phosphothreonine; by CDK2Combined sources1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated at Ser-775, Ser-779, Ser-1100, Thr-1270 and Thr-1350 by CCNE1/CDK2 at G1-S transition and until prophase, which promotes association with histone gene clusters and stimulates activation of histone transcription. Also phosphorylated by CCNA1/CDK2 in vitro.3 Publications

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q14207

MaxQB - The MaxQuant DataBase

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MaxQBi
Q14207

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q14207

PeptideAtlas

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PeptideAtlasi
Q14207

PRoteomics IDEntifications database

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PRIDEi
Q14207

ProteomicsDB human proteome resource

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ProteomicsDBi
59930

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q14207

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q14207

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitously expressed.2 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed throughout the cell cycle. Expression peaks at the G1/S phase boundary and declines during S phase.2 Publications

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By expression of E2F1, E2F2, E2F3 and E2F4. Expression is reduced in response to radiation-induced DNA damage.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000149308 Expressed in 216 organ(s), highest expression level in secondary oocyte

CleanEx database of gene expression profiles

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CleanExi
HS_NPAT

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q14207 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q14207 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA045908
HPA066370

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with the cylin/CDK complexes CCNE1/CDK2 and CCNA1/CDK2. Interacts with BZW1, CASP8AP2, CREBBP, MIZF and YY1. Interacts with the RUVBL1, RUVBL2 and TRRAP subunits of the NuA4 complex. May also interact with GAPDH, NME1, NME2 and STIP1.7 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
110924, 32 interactors

Database of interacting proteins

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DIPi
DIP-59961N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

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ELMi
Q14207

Protein interaction database and analysis system

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IntActi
Q14207, 10 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000278612

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q14207

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q14207

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini3 – 35LisHPROSITE-ProRule annotationAdd BLAST33

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 318Interaction with MIZF1 PublicationAdd BLAST318
Regioni5 – 25Required for activation of histone gene transcription and interaction with MIZF1 PublicationAdd BLAST21
Regioni121 – 145Required for activation of histone gene transcription and interaction with MIZF1 PublicationAdd BLAST25
Regioni262 – 338Mediates transcriptional activationAdd BLAST77
Regioni629 – 653Required for acceleration of G1 phaseAdd BLAST25
Regioni828 – 853Required for acceleration of G1 phaseAdd BLAST26
Regioni1039 – 1054Required for acceleration of G1 phaseAdd BLAST16
Regioni1228 – 1252Required for acceleration of G1 phaseAdd BLAST25
Regioni1325 – 1349Required for acceleration of G1 phaseAdd BLAST25

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The LisH domain is required for the activation of histone gene transcription.1 Publication

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NPAT family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IHIA Eukaryota
ENOG41112YA LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000012388

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG108198

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q14207

Identification of Orthologs from Complete Genome Data

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OMAi
KQMVIEN

Database of Orthologous Groups

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OrthoDBi
EOG091G00OU

Database for complete collections of gene phylogenies

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PhylomeDBi
Q14207

TreeFam database of animal gene trees

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TreeFami
TF332825

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR006594 LisH
IPR031442 NPAT_C

Pfam protein domain database

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Pfami
View protein in Pfam
PF15712 NPAT_C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00667 LisH, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50896 LISH, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q14207-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLLPSDVARL VLGYLQQENL ISTCQTFILE SSDLKEYAEH CTDEGFIPAC
60 70 80 90 100
LLSLFGKNLT TILNEYVAMK TKETSNNVPA IMSSLWKKLD HTLSQIRSMQ
110 120 130 140 150
SSPRFAGSQR ARTRTGIAEI KRQRKLASQT APASAELLTL PYLSGQFTTP
160 170 180 190 200
PSTGTQVTRP SGQISDPSRS YFVVVNHSQS QDTVTTGEAL NVIPGAQEKK
210 220 230 240 250
AHASLMSPGR RKSESQRKST TLSGPHSTIR NFQDPNAFAV EKQMVIENAR
260 270 280 290 300
EKILSNKSLQ EKLAENINKF LTSDNNIAQV PKQTDNNPTE PETSIDEFLG
310 320 330 340 350
LPSEIHMSEE AIQDILEQTE SDPAFQALFD LFDYGKTKNN KNISQSISSQ
360 370 380 390 400
PMESNPSIVL ADETNLAVKG SFETEESDGQ SGQPAFCTSY QNDDPLNALK
410 420 430 440 450
NSNNHDVLRQ EDQENFSQIS TSIQKKAFKT AVPTEQKCDI DITFESVPNL
460 470 480 490 500
NDFNQRGNSN AECNPHCAEL YTNQMSTETE MAIGIEKNSL SSNVPSESQL
510 520 530 540 550
QPDQPDIPIT SFVSLGCEAN NENLILSGKS SQLLSQDTSL TGKPSKKSQF
560 570 580 590 600
CENSNDTVKL KINFHGSKSS DSSEVHKSKI EINVLEPVMS QLSNCQDNSC
610 620 630 640 650
LQSEILPVSV ESSHLNVSGQ VEIHLGDSLS STKQPSNDSA SVELNHTENE
660 670 680 690 700
AQASKSENSQ EPSSSVKEEN TIFLSLGGNA NCEKVALTPP EGTPVENSHS
710 720 730 740 750
LPPESVCSSV GDSHPESQNT DDKPSSNNSA EIDASNIVSL KVIISDDPFV
760 770 780 790 800
SSDTELTSAV SSINGENLPT IILSSPTKSP TKNAELVKCL SSEETVGAVV
810 820 830 840 850
YAEVGDSASM EQSLLTFKSE DSAVNNTQNE DGIAFSANVT PCVSKDGGYI
860 870 880 890 900
QLMPATSTAF GNSNNILIAT CVTDPTALGT SVSQSNVVVL PGNSAPMTAQ
910 920 930 940 950
PLPPQLQTPP RSNSVFAVNQ AVSPNFSQGS AIIIASPVQP VLQGMVGMIP
960 970 980 990 1000
VSVVGQNGNN FSTPPRQVLH MPLTAPVCNR SIPQFPVPPK SQKAQGLRNK
1010 1020 1030 1040 1050
PCIGKQVNNL VDSSGHSVGC HAQKTEVSDK SIATDLGKKS EETTVPFPEE
1060 1070 1080 1090 1100
SIVPAAKPCH RRVLCFDSTT APVANTQGPN HKMVSQNKER NAVSFPNLDS
1110 1120 1130 1140 1150
PNVSSTLKPP SNNAIKREKE KPPLPKILSK SESAISRHTT IRETQSEKKV
1160 1170 1180 1190 1200
SPTEIVLESF HKATANKENE LCSDVERQKN PENSKLSIGQ QNGGLRSEKS
1210 1220 1230 1240 1250
IASLQEMTKK QGTSSNNKNV LSVGTAVKDL KQEQTKSASS LITTEMLQDI
1260 1270 1280 1290 1300
QRHSSVSRLA DSSDLPVPRT PGSGAGEKHK EEPIDIIKAP SSRRFSEDSS
1310 1320 1330 1340 1350
TSKVMVPPVT PDLPACSPAS ETGSENSVNM AAHTLMILSR AAISRTTSAT
1360 1370 1380 1390 1400
PLKDNTQQFR ASSRSTTKKR KIEELDERER NSRPSSKNLT NSSIPMKKKK
1410 1420
IKKKKLPSSF PAGMDVDKFL LSLHYDE
Length:1,427
Mass (Da):154,290
Last modified:May 18, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD5C5E630A56227F9
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YET3H0YET3_HUMAN
Protein NPAT
NPAT
299Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PKJ1E9PKJ1_HUMAN
Protein NPAT
NPAT
60Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAB02735 differs from that shown. Chimeric cDNA. A chimeric cDNA originating from chromosomes 11 and 4.Curated
The sequence AAH40356 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAH50561 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti22S → Y in AAB02735 (PubMed:9060412).Curated1
Sequence conflicti101S → N in BAF84376 (PubMed:14702039).Curated1
Sequence conflicti329F → L in BAF84376 (PubMed:14702039).Curated1
Sequence conflicti471Y → N in CAA65824 (PubMed:8923007).Curated1
Sequence conflicti785E → G in BAF82709 (PubMed:14702039).Curated1
Sequence conflicti1145Q → R in BAF82709 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_038696295I → L1 PublicationCorresponds to variant dbSNP:rs1131748Ensembl.1
Natural variantiVAR_038697399L → M1 PublicationCorresponds to variant dbSNP:rs1051521Ensembl.1
Natural variantiVAR_038698447V → M. Corresponds to variant dbSNP:rs35504388Ensembl.1
Natural variantiVAR_038699483I → L. Corresponds to variant dbSNP:rs968207Ensembl.1
Natural variantiVAR_038700540L → F1 PublicationCorresponds to variant dbSNP:rs4144901Ensembl.1
Natural variantiVAR_038701575V → I5 PublicationsCorresponds to variant dbSNP:rs2070661Ensembl.1
Natural variantiVAR_038702608V → A. Corresponds to variant dbSNP:rs35095430Ensembl.1
Natural variantiVAR_038703621V → I1 PublicationCorresponds to variant dbSNP:rs1051522Ensembl.1
Natural variantiVAR_038704967Q → E1 PublicationCorresponds to variant dbSNP:rs1131750Ensembl.1
Natural variantiVAR_038705973L → V1 PublicationCorresponds to variant dbSNP:rs1131751Ensembl.1
Natural variantiVAR_038706987V → A1 PublicationCorresponds to variant dbSNP:rs1051524Ensembl.1
Natural variantiVAR_038707999N → K1 PublicationCorresponds to variant dbSNP:rs34052882Ensembl.1
Natural variantiVAR_0387081191Q → R1 PublicationCorresponds to variant dbSNP:rs1051525Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
D83243 mRNA Translation: BAA11861.1
X97186 mRNA Translation: CAA65824.1
D89854 Genomic DNA Translation: BAA21367.1
AK290020 mRNA Translation: BAF82709.1
AK291687 mRNA Translation: BAF84376.1
BC040356 mRNA Translation: AAH40356.1 Sequence problems.
BC050561 mRNA Translation: AAH50561.1 Sequence problems.
U58852 mRNA Translation: AAB02735.1 Sequence problems.

The Consensus CDS (CCDS) project

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CCDSi
CCDS41710.1

NCBI Reference Sequences

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RefSeqi
NP_002510.2, NM_002519.2

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.171061

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000278612; ENSP00000278612; ENSG00000149308

Database of genes from NCBI RefSeq genomes

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GeneIDi
4863

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:4863

UCSC genome browser

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UCSCi
uc001pjz.6 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D83243 mRNA Translation: BAA11861.1
X97186 mRNA Translation: CAA65824.1
D89854 Genomic DNA Translation: BAA21367.1
AK290020 mRNA Translation: BAF82709.1
AK291687 mRNA Translation: BAF84376.1
BC040356 mRNA Translation: AAH40356.1 Sequence problems.
BC050561 mRNA Translation: AAH50561.1 Sequence problems.
U58852 mRNA Translation: AAB02735.1 Sequence problems.
CCDSiCCDS41710.1
RefSeqiNP_002510.2, NM_002519.2
UniGeneiHs.171061

3D structure databases

ProteinModelPortaliQ14207
SMRiQ14207
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110924, 32 interactors
DIPiDIP-59961N
ELMiQ14207
IntActiQ14207, 10 interactors
STRINGi9606.ENSP00000278612

PTM databases

iPTMnetiQ14207
PhosphoSitePlusiQ14207

Polymorphism and mutation databases

BioMutaiNPAT
DMDMi296439285

Proteomic databases

EPDiQ14207
MaxQBiQ14207
PaxDbiQ14207
PeptideAtlasiQ14207
PRIDEiQ14207
ProteomicsDBi59930

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000278612; ENSP00000278612; ENSG00000149308
GeneIDi4863
KEGGihsa:4863
UCSCiuc001pjz.6 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
4863
DisGeNETi4863
EuPathDBiHostDB:ENSG00000149308.16

GeneCards: human genes, protein and diseases

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GeneCardsi
NPAT

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0035981
HGNCiHGNC:7896 NPAT
HPAiHPA045908
HPA066370
MIMi601448 gene
neXtProtiNX_Q14207
OpenTargetsiENSG00000149308
PharmGKBiPA31697

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IHIA Eukaryota
ENOG41112YA LUCA
GeneTreeiENSGT00390000012388
HOVERGENiHBG108198
InParanoidiQ14207
OMAiKQMVIEN
OrthoDBiEOG091G00OU
PhylomeDBiQ14207
TreeFamiTF332825

Enzyme and pathway databases

SIGNORiQ14207

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
NPAT human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
NPAT_(gene)

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
4863

Protein Ontology

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PROi
PR:Q14207

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000149308 Expressed in 216 organ(s), highest expression level in secondary oocyte
CleanExiHS_NPAT
ExpressionAtlasiQ14207 baseline and differential
GenevisibleiQ14207 HS

Family and domain databases

InterProiView protein in InterPro
IPR006594 LisH
IPR031442 NPAT_C
PfamiView protein in Pfam
PF15712 NPAT_C, 1 hit
SMARTiView protein in SMART
SM00667 LisH, 1 hit
PROSITEiView protein in PROSITE
PS50896 LISH, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNPAT_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q14207
Secondary accession number(s): A8K1V5
, A8K6M2, Q13632, Q14967, Q16580, Q86W55, Q8IWE9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: May 18, 2010
Last modified: November 7, 2018
This is version 118 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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