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Protein

Calcipressin-2

Gene

RCAN2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development.

GO - Molecular functioni

  • calcium-dependent protein serine/threonine phosphatase regulator activity Source: GO_Central
  • nucleic acid binding Source: InterPro

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Calcipressin-2
Alternative name(s):
Down syndrome candidate region 1-like 1
Myocyte-enriched calcineurin-interacting protein 2
Short name:
MCIP2
Regulator of calcineurin 2
Thyroid hormone-responsive protein ZAKI-4
Gene namesi
Name:RCAN2
Synonyms:DSCR1L1, ZAKI4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000172348.14
HGNCiHGNC:3041 RCAN2
MIMi604876 gene
neXtProtiNX_Q14206

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

DisGeNETi10231
OpenTargetsiENSG00000172348
PharmGKBiPA162400959

Polymorphism and mutation databases

BioMutaiRCAN2
DMDMi158958336

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002114171 – 197Calcipressin-2Add BLAST197

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei167PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ14206
PeptideAtlasiQ14206
PRIDEiQ14206
ProteomicsDBi59928
59929 [Q14206-2]

PTM databases

PhosphoSitePlusiQ14206

Expressioni

Tissue specificityi

Expressed in fibroblasts, heart, brain, liver, and skeletal muscle but not in placenta, lung, kidney and pancreas.

Inductioni

By thyroid hormone.

Gene expression databases

BgeeiENSG00000172348 Expressed in 234 organ(s), highest expression level in lateral nuclear group of thalamus
CleanExiHS_RCAN2
ExpressionAtlasiQ14206 baseline and differential
GenevisibleiQ14206 HS

Organism-specific databases

HPAiHPA053880

Interactioni

Protein-protein interaction databases

BioGridi115525, 22 interactors
IntActiQ14206, 1 interactor
STRINGi9606.ENSP00000329454

Structurei

3D structure databases

ProteinModelPortaliQ14206
SMRiQ14206
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RCAN family.Curated

Phylogenomic databases

eggNOGiKOG4019 Eukaryota
ENOG4111I50 LUCA
GeneTreeiENSGT00400000022053
HOVERGENiHBG018932
InParanoidiQ14206
KOiK17903
OMAiMPARSMD
OrthoDBiEOG091G0OZ7
PhylomeDBiQ14206
TreeFamiTF313579

Family and domain databases

CDDicd12709 RRM_RCAN2, 1 hit
Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR006931 Calcipressin
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR034921 RCAN2
IPR034919 RCAN2_RRM
PANTHERiPTHR10300 PTHR10300, 1 hit
PTHR10300:SF5 PTHR10300:SF5, 1 hit
PfamiView protein in Pfam
PF04847 Calcipressin, 1 hit
SUPFAMiSSF54928 SSF54928, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q14206-1) [UniParc]FASTAAdd to basket
Also known as: ZAKI-4 alpha

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPAPSMDCDV STLVACVVDV EVFTNQEVKE KFEGLFRTYD DCVTFQLFKS
60 70 80 90 100
FRRVRINFSN PKSAARARIE LHETQFRGKK LKLYFAQVQT PETDGDKLHL
110 120 130 140 150
APPQPAKQFL ISPPSSPPVG WQPINDATPV LNYDLLYAVA KLGPGEKYEL
160 170 180 190
HAGTESTPSV VVHVCDSDIE EEEDPKTSPK PKIIQTRRPG LPPSVSN
Length:197
Mass (Da):21,997
Last modified:July 24, 2007 - v3
Checksum:i9FD36B3DEDAE22B8
GO
Isoform 2 (identifier: Q14206-2) [UniParc]FASTAAdd to basket
Also known as: ZAKI-4 beta

The sequence of this isoform differs from the canonical sequence as follows:
     1-28: MPAPSMDCDVSTLVACVVDVEVFTNQEV → MRGESYFIGM...HQSVFEGEES

Show »
Length:243
Mass (Da):27,289
Checksum:i48EA6BCCA2669ABC
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MSB6A0A0A0MSB6_HUMAN
Calcipressin-2
RCAN2
224Annotation score:

Sequence cautioni

The sequence BAA11911 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti33E → G in BAA11911 (PubMed:8662924).Curated1
Sequence conflicti33E → G in AAK59805 (PubMed:12102656).Curated1
Sequence conflicti33E → G in AAK59806 (PubMed:12102656).Curated1
Sequence conflicti120G → S in BAA11911 (PubMed:8662924).Curated1
Sequence conflicti120G → S in AAK59805 (PubMed:12102656).Curated1
Sequence conflicti120G → S in AAK59806 (PubMed:12102656).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0269231 – 28MPAPS…TNQEV → MRGESYFIGMRSPGQQGHVP EDGGLFLLCCIDRDWAVTRC FAEEAFQAITDFNDLPNSLF ACNVHQSVFEGEES in isoform 2. 2 PublicationsAdd BLAST28

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D83407 mRNA Translation: BAA11911.1 Different initiation.
AY034085 mRNA Translation: AAK59805.1
AY034086 mRNA Translation: AAK59806.1
AK090990 mRNA Translation: BAG52258.1
AL390741 Genomic DNA No translation available.
AL359633 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX04294.1
CCDSiCCDS43469.1 [Q14206-1]
CCDS59023.1 [Q14206-2]
RefSeqiNP_001238902.1, NM_001251973.1 [Q14206-2]
NP_001238903.1, NM_001251974.1 [Q14206-2]
NP_005813.2, NM_005822.3 [Q14206-1]
XP_011512528.1, XM_011514226.1 [Q14206-2]
UniGeneiHs.440168
Hs.710016

Genome annotation databases

EnsembliENST00000306764; ENSP00000305223; ENSG00000172348 [Q14206-2]
ENST00000330430; ENSP00000329454; ENSG00000172348 [Q14206-1]
ENST00000371374; ENSP00000360425; ENSG00000172348 [Q14206-2]
GeneIDi10231
KEGGihsa:10231
UCSCiuc003oyb.3 human [Q14206-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D83407 mRNA Translation: BAA11911.1 Different initiation.
AY034085 mRNA Translation: AAK59805.1
AY034086 mRNA Translation: AAK59806.1
AK090990 mRNA Translation: BAG52258.1
AL390741 Genomic DNA No translation available.
AL359633 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX04294.1
CCDSiCCDS43469.1 [Q14206-1]
CCDS59023.1 [Q14206-2]
RefSeqiNP_001238902.1, NM_001251973.1 [Q14206-2]
NP_001238903.1, NM_001251974.1 [Q14206-2]
NP_005813.2, NM_005822.3 [Q14206-1]
XP_011512528.1, XM_011514226.1 [Q14206-2]
UniGeneiHs.440168
Hs.710016

3D structure databases

ProteinModelPortaliQ14206
SMRiQ14206
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115525, 22 interactors
IntActiQ14206, 1 interactor
STRINGi9606.ENSP00000329454

PTM databases

PhosphoSitePlusiQ14206

Polymorphism and mutation databases

BioMutaiRCAN2
DMDMi158958336

Proteomic databases

PaxDbiQ14206
PeptideAtlasiQ14206
PRIDEiQ14206
ProteomicsDBi59928
59929 [Q14206-2]

Protocols and materials databases

DNASUi10231
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000306764; ENSP00000305223; ENSG00000172348 [Q14206-2]
ENST00000330430; ENSP00000329454; ENSG00000172348 [Q14206-1]
ENST00000371374; ENSP00000360425; ENSG00000172348 [Q14206-2]
GeneIDi10231
KEGGihsa:10231
UCSCiuc003oyb.3 human [Q14206-1]

Organism-specific databases

CTDi10231
DisGeNETi10231
EuPathDBiHostDB:ENSG00000172348.14
GeneCardsiRCAN2
H-InvDBiHIX0005935
HGNCiHGNC:3041 RCAN2
HPAiHPA053880
MIMi604876 gene
neXtProtiNX_Q14206
OpenTargetsiENSG00000172348
PharmGKBiPA162400959
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4019 Eukaryota
ENOG4111I50 LUCA
GeneTreeiENSGT00400000022053
HOVERGENiHBG018932
InParanoidiQ14206
KOiK17903
OMAiMPARSMD
OrthoDBiEOG091G0OZ7
PhylomeDBiQ14206
TreeFamiTF313579

Miscellaneous databases

ChiTaRSiRCAN2 human
GeneWikiiRCAN2
GenomeRNAii10231
PROiPR:Q14206
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000172348 Expressed in 234 organ(s), highest expression level in lateral nuclear group of thalamus
CleanExiHS_RCAN2
ExpressionAtlasiQ14206 baseline and differential
GenevisibleiQ14206 HS

Family and domain databases

CDDicd12709 RRM_RCAN2, 1 hit
Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR006931 Calcipressin
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR034921 RCAN2
IPR034919 RCAN2_RRM
PANTHERiPTHR10300 PTHR10300, 1 hit
PTHR10300:SF5 PTHR10300:SF5, 1 hit
PfamiView protein in Pfam
PF04847 Calcipressin, 1 hit
SUPFAMiSSF54928 SSF54928, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRCAN2_HUMAN
AccessioniPrimary (citable) accession number: Q14206
Secondary accession number(s): A6ND07
, B3KR46, Q5VWF7, Q5VWF8, Q8N116
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: July 24, 2007
Last modified: September 12, 2018
This is version 143 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
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