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Protein

Zinc finger MYM-type protein 3

Gene

ZMYM3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in the regulation of cell morphology and cytoskeletal organization.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri332 – 366MYM-type 1Add BLAST35
Zinc fingeri378 – 422MYM-type 2Add BLAST45
Zinc fingeri429 – 464MYM-type 3Add BLAST36
Zinc fingeri477 – 511MYM-type 4Add BLAST35
Zinc fingeri521 – 559MYM-type 5Add BLAST39
Zinc fingeri567 – 604MYM-type 6Add BLAST38
Zinc fingeri612 – 646MYM-type 7Add BLAST35
Zinc fingeri653 – 692MYM-type 8Add BLAST40
Zinc fingeri699 – 733MYM-type 9Add BLAST35

GO - Molecular functioni

GO - Biological processi

  • cytoskeleton organization Source: UniProtKB
  • multicellular organism development Source: ProtInc
  • regulation of cell morphogenesis Source: UniProtKB

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger MYM-type protein 3
Alternative name(s):
Zinc finger protein 261
Gene namesi
Name:ZMYM3
Synonyms:DXS6673E, KIAA0385, ZNF261
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000147130.14
HGNCiHGNC:13054 ZMYM3
MIMi300061 gene
neXtProtiNX_Q14202

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

A chromosomal aberration involving ZMYM3 may be a cause of X-linked mental retardation in Xq13.1. Translocation t(X;13)(q13.1;?).1 Publication

Organism-specific databases

DisGeNETi9203
OpenTargetsiENSG00000147130
PharmGKBiPA37632

Polymorphism and mutation databases

BioMutaiZMYM3
DMDMi12644413

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001913781 – 1370Zinc finger MYM-type protein 3Add BLAST1370

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei263PhosphoserineCombined sources1
Modified residuei267PhosphoserineCombined sources1
Cross-linki308Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki320Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki328Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei464PhosphoserineCombined sources1
Cross-linki778Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki786Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei795PhosphothreonineCombined sources1
Cross-linki804Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei817PhosphothreonineCombined sources1
Modified residuei826PhosphothreonineCombined sources1
Cross-linki847Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki861Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki920Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1275Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Isoform 2 (identifier: Q14202-2)
Cross-linki786Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ14202
MaxQBiQ14202
PaxDbiQ14202
PeptideAtlasiQ14202
PRIDEiQ14202
ProteomicsDBi59922
59923 [Q14202-2]
59924 [Q14202-3]

PTM databases

iPTMnetiQ14202
PhosphoSitePlusiQ14202

Expressioni

Tissue specificityi

Most abundant in brain, moderate in muscle and heart, low in other tissues except placenta.

Gene expression databases

BgeeiENSG00000147130 Expressed in 225 organ(s), highest expression level in left ovary
CleanExiHS_ZMYM3
ExpressionAtlasiQ14202 baseline and differential
GenevisibleiQ14202 HS

Organism-specific databases

HPAiHPA003211
HPA075255

Interactioni

Subunit structurei

May be a component of a BHC histone deacetylase complex that contains HDAC1, HDAC2, HMG20B/BRAF35, KDM1A, RCOR1/CoREST, PHF21A/BHC80, ZMYM2, ZNF217, ZMYM3, GSE1 and GTF2I.1 Publication

Protein-protein interaction databases

BioGridi114637, 49 interactors
CORUMiQ14202
IntActiQ14202, 23 interactors
MINTiQ14202
STRINGi9606.ENSP00000322845

Structurei

3D structure databases

ProteinModelPortaliQ14202
SMRiQ14202
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri332 – 366MYM-type 1Add BLAST35
Zinc fingeri378 – 422MYM-type 2Add BLAST45
Zinc fingeri429 – 464MYM-type 3Add BLAST36
Zinc fingeri477 – 511MYM-type 4Add BLAST35
Zinc fingeri521 – 559MYM-type 5Add BLAST39
Zinc fingeri567 – 604MYM-type 6Add BLAST38
Zinc fingeri612 – 646MYM-type 7Add BLAST35
Zinc fingeri653 – 692MYM-type 8Add BLAST40
Zinc fingeri699 – 733MYM-type 9Add BLAST35

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IE8I Eukaryota
ENOG410XQR6 LUCA
GeneTreeiENSGT00550000074408
HOGENOMiHOG000293258
HOVERGENiHBG057545
InParanoidiQ14202
PhylomeDBiQ14202
TreeFamiTF336988

Family and domain databases

InterProiView protein in InterPro
IPR021893 DUF3504
IPR011017 TRASH_dom
IPR010507 Znf_MYM
PfamiView protein in Pfam
PF12012 DUF3504, 1 hit
PF06467 zf-FCS, 8 hits
SMARTiView protein in SMART
SM00746 TRASH, 10 hits

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.iShow all

Isoform 1 (identifier: Q14202-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDPSDFPSPF DPLTLPEKPL AGDLPVDMEF GEDLLESQTA PTRGWAPPGP
60 70 80 90 100
SPSSGALDLL DTPAGLEKDP GVLDGATELL GLGGLLYKAP SPPEVDHGPE
110 120 130 140 150
GTLAWDAGDQ TLEPGPGGQT PEVVPPDPGA GANSCSPEGL LEPLAPDSPI
160 170 180 190 200
TLQSPHIEEE ETTSIATARR GSPGQEEELP QGQPQSPNAP PSPSVGETLG
210 220 230 240 250
DGINSSQTKP GGSSPPAHPS LPGDGLTAKA SEKPPERKRS ERVRRAEPPK
260 270 280 290 300
PEVVDSTESI PVSDEDSDAM VDDPNDEDFV PFRPRRSPRM SLRSSVSQRA
310 320 330 340 350
GRSAVGTKMT CAHCRTPLQK GQTAYQRKGL PQLFCSSSCL TTFSKKPSGK
360 370 380 390 400
KTCTFCKKEI WNTKDSVVAQ TGSGGSFHEF CTSVCLSLYE AQQQRPIPQS
410 420 430 440 450
GDPADATRCS ICQKTGEVLH EVSNGSVVHR LCSDSCFSKF RANKGLKTNC
460 470 480 490 500
CDQCGAYIYT KTGSPGPELL FHEGQQKRFC NTTCLGAYKK KNTRVYPCVW
510 520 530 540 550
CKTLCKNFEM LSHVDRNGKT SLFCSLCCTT SYKVKQAGLT GPPRPCSFCR
560 570 580 590 600
RSLSDPCYYN KVDRTVYQFC SPSCWTKFQR TSPEGGIHLS CHYCHSLFSG
610 620 630 640 650
KPEVLDWQDQ VFQFCCRDCC EDFKRLRGVV SQCEHCRQEK LLHEKLRFSG
660 670 680 690 700
VEKSFCSEGC VLLYKQDFTK KLGLCCITCT YCSQTCQRGV TEQLDGSTWD
710 720 730 740 750
FCSEDCKSKY LLWYCKAARC HACKRQGKLL ETIHWRGQIR HFCNQQCLLR
760 770 780 790 800
FYSQQNQPNL DTQSGPESLL NSQSPESKPQ TPSQTKVENS NTVRTPEENG
810 820 830 840 850
NLGKIPVKTR SAPTAPTPPP PPPPATPRKN KAAMCKPLMQ NRGVSCKVEM
860 870 880 890 900
KSKGSQTEEW KPQVIVLPIP VPIFVPVPMH LYCQKVPVPF SMPIPVPVPM
910 920 930 940 950
FLPTTLESTD KIVETIEELK VKIPSNPLEA DILAMAEMIA EAEELDKASS
960 970 980 990 1000
DLCDLVSNQS AEGLLEDCDL FGPARDDVLA MAVKMANVLD EPGQDLEADF
1010 1020 1030 1040 1050
PKNPLDINPS VDFLFDCGLV GPEDVSTEQD LPRTMRKGQK RLVLSESCSR
1060 1070 1080 1090 1100
DSMSSQPSCT GLNYSYGVNA WKCWVQSKYA NGETSKGDEL RFGPKPMRIK
1110 1120 1130 1140 1150
EDILACSAAE LNYGLAQFVR EITRPNGERY EPDSIYYLCL GIQQYLLENN
1160 1170 1180 1190 1200
RMVNIFTDLY YLTFVQELNK SLSTWQPTLL PNNTVFSRVE EEHLWECKQL
1210 1220 1230 1240 1250
GVYSPFVLLN TLMFFNTKFF GLQTAEEHMQ LSFTNVVRQS RKCTTPRGTT
1260 1270 1280 1290 1300
KVVSIRYYAP VRQRKGRDTG PGKRKREDEA PILEQRENRM NPLRCPVKFY
1310 1320 1330 1340 1350
EFYLSKCPES LRTRNDVFYL QPERSCIAES PLWYSVIPMD RSMLESMLNR
1360 1370
ILAVREIYEE LGRPGEEDLD
Length:1,370
Mass (Da):152,379
Last modified:December 1, 2000 - v2
Checksum:i088B5E01E7EE9C30
GO
Isoform 2 (identifier: Q14202-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     793-804: Missing.

Note: No experimental confirmation available.Combined sources
Show »
Length:1,358
Mass (Da):151,084
Checksum:i8B636620F05DF82F
GO
Isoform 3 (identifier: Q14202-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     491-495: KNTRV → VGPRE
     496-1370: Missing.

Show »
Length:495
Mass (Da):52,485
Checksum:iAC0D49C9F3D9CC15
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A6NHB5A6NHB5_HUMAN
Zinc finger MYM-type protein 3
ZMYM3
1,372Annotation score:
A6NHN7A6NHN7_HUMAN
Zinc finger MYM-type protein 3
ZMYM3
1,280Annotation score:
A6NL54A6NL54_HUMAN
Zinc finger MYM-type protein 3
ZMYM3
497Annotation score:
A6NC58A6NC58_HUMAN
Zinc finger MYM-type protein 3
ZMYM3
349Annotation score:

Sequence cautioni

The sequence BAA20839 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_043262491 – 495KNTRV → VGPRE in isoform 3. 2 Publications5
Alternative sequenceiVSP_043263496 – 1370Missing in isoform 3. 2 PublicationsAdd BLAST875
Alternative sequenceiVSP_004492793 – 804Missing in isoform 2. 1 PublicationAdd BLAST12

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X95808 mRNA Translation: CAA65075.1
AB002383 mRNA Translation: BAA20839.2 Different initiation.
BT007095 mRNA Translation: AAP35759.1
AL590762 Genomic DNA No translation available.
CH471132 Genomic DNA Translation: EAX05302.1
CH471132 Genomic DNA Translation: EAX05303.1
BC069057 mRNA Translation: AAH69057.1
BC013009 mRNA Translation: AAH13009.1
CCDSiCCDS14409.1 [Q14202-1]
CCDS55443.1 [Q14202-3]
CCDS55444.1 [Q14202-2]
RefSeqiNP_001164633.1, NM_001171162.1 [Q14202-2]
NP_001164634.1, NM_001171163.1 [Q14202-3]
NP_005087.1, NM_005096.3 [Q14202-1]
NP_963893.1, NM_201599.2 [Q14202-1]
XP_005262366.1, XM_005262309.3 [Q14202-1]
XP_005262367.1, XM_005262310.2 [Q14202-2]
XP_011529364.1, XM_011531062.2 [Q14202-1]
UniGeneiHs.522684

Genome annotation databases

EnsembliENST00000314425; ENSP00000322845; ENSG00000147130 [Q14202-1]
ENST00000373981; ENSP00000363093; ENSG00000147130 [Q14202-3]
ENST00000373998; ENSP00000363110; ENSG00000147130 [Q14202-2]
GeneIDi9203
KEGGihsa:9203
UCSCiuc004dzh.3 human [Q14202-1]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement

Similar proteinsi

Entry informationi

Entry nameiZMYM3_HUMAN
AccessioniPrimary (citable) accession number: Q14202
Secondary accession number(s): D3DVV3, O15089, Q96E26
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: December 1, 2000
Last modified: September 12, 2018
This is version 152 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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