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Entry version 165 (26 Feb 2020)
Sequence version 2 (01 Dec 2000)
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Protein

Zinc finger MYM-type protein 3

Gene

ZMYM3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a role in the regulation of cell morphology and cytoskeletal organization.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri332 – 366MYM-type 1Add BLAST35
Zinc fingeri378 – 422MYM-type 2Add BLAST45
Zinc fingeri429 – 464MYM-type 3Add BLAST36
Zinc fingeri477 – 511MYM-type 4Add BLAST35
Zinc fingeri521 – 559MYM-type 5Add BLAST39
Zinc fingeri567 – 604MYM-type 6Add BLAST38
Zinc fingeri612 – 646MYM-type 7Add BLAST35
Zinc fingeri653 – 692MYM-type 8Add BLAST40
Zinc fingeri699 – 733MYM-type 9Add BLAST35

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger MYM-type protein 3
Alternative name(s):
Zinc finger protein 261
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZMYM3
Synonyms:DXS6673E, KIAA0385, ZNF261
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:13054 ZMYM3

Online Mendelian Inheritance in Man (OMIM)

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MIMi
300061 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q14202

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

A chromosomal aberration involving ZMYM3 may be a cause of X-linked mental retardation in Xq13.1. Translocation t(X;13)(q13.1;?).1 Publication

Organism-specific databases

DisGeNET

More...
DisGeNETi
9203

Open Targets

More...
OpenTargetsi
ENSG00000147130

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA37632

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q14202 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZMYM3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
12644413

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001913781 – 1370Zinc finger MYM-type protein 3Add BLAST1370

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei263PhosphoserineCombined sources1
Modified residuei267PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki308Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki320Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki328Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei464PhosphoserineCombined sources1
Cross-linki778Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki786Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei795PhosphothreonineCombined sources1
Cross-linki804Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei817PhosphothreonineCombined sources1
Modified residuei826PhosphothreonineCombined sources1
Cross-linki847Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki861Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki920Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1275Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Isoform 2 (identifier: Q14202-2)
Cross-linki786Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q14202

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q14202

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q14202

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q14202

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q14202

PeptideAtlas

More...
PeptideAtlasi
Q14202

PRoteomics IDEntifications database

More...
PRIDEi
Q14202

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
59922 [Q14202-1]
59923 [Q14202-2]
59924 [Q14202-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q14202

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q14202

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Most abundant in brain, moderate in muscle and heart, low in other tissues except placenta.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000147130 Expressed in left ovary and 224 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q14202 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q14202 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA003211
HPA075255

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

May be a component of a BHC histone deacetylase complex that contains HDAC1, HDAC2, HMG20B/BRAF35, KDM1A, RCOR1/CoREST, PHF21A/BHC80, ZMYM2, ZNF217, ZMYM3, GSE1 and GTF2I.

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
114637, 71 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q14202

Protein interaction database and analysis system

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IntActi
Q14202, 38 interactors

Molecular INTeraction database

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MINTi
Q14202

STRING: functional protein association networks

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STRINGi
9606.ENSP00000322845

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q14202 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q14202

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri332 – 366MYM-type 1Add BLAST35
Zinc fingeri378 – 422MYM-type 2Add BLAST45
Zinc fingeri429 – 464MYM-type 3Add BLAST36
Zinc fingeri477 – 511MYM-type 4Add BLAST35
Zinc fingeri521 – 559MYM-type 5Add BLAST39
Zinc fingeri567 – 604MYM-type 6Add BLAST38
Zinc fingeri612 – 646MYM-type 7Add BLAST35
Zinc fingeri653 – 692MYM-type 8Add BLAST40
Zinc fingeri699 – 733MYM-type 9Add BLAST35

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IE8I Eukaryota
ENOG410XQR6 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160693

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_004099_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q14202

Database of Orthologous Groups

More...
OrthoDBi
587724at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q14202

TreeFam database of animal gene trees

More...
TreeFami
TF336988

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR021893 DUF3504
IPR011017 TRASH_dom
IPR010507 Znf_MYM

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12012 DUF3504, 1 hit
PF06467 zf-FCS, 8 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00746 TRASH, 10 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q14202-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDPSDFPSPF DPLTLPEKPL AGDLPVDMEF GEDLLESQTA PTRGWAPPGP
60 70 80 90 100
SPSSGALDLL DTPAGLEKDP GVLDGATELL GLGGLLYKAP SPPEVDHGPE
110 120 130 140 150
GTLAWDAGDQ TLEPGPGGQT PEVVPPDPGA GANSCSPEGL LEPLAPDSPI
160 170 180 190 200
TLQSPHIEEE ETTSIATARR GSPGQEEELP QGQPQSPNAP PSPSVGETLG
210 220 230 240 250
DGINSSQTKP GGSSPPAHPS LPGDGLTAKA SEKPPERKRS ERVRRAEPPK
260 270 280 290 300
PEVVDSTESI PVSDEDSDAM VDDPNDEDFV PFRPRRSPRM SLRSSVSQRA
310 320 330 340 350
GRSAVGTKMT CAHCRTPLQK GQTAYQRKGL PQLFCSSSCL TTFSKKPSGK
360 370 380 390 400
KTCTFCKKEI WNTKDSVVAQ TGSGGSFHEF CTSVCLSLYE AQQQRPIPQS
410 420 430 440 450
GDPADATRCS ICQKTGEVLH EVSNGSVVHR LCSDSCFSKF RANKGLKTNC
460 470 480 490 500
CDQCGAYIYT KTGSPGPELL FHEGQQKRFC NTTCLGAYKK KNTRVYPCVW
510 520 530 540 550
CKTLCKNFEM LSHVDRNGKT SLFCSLCCTT SYKVKQAGLT GPPRPCSFCR
560 570 580 590 600
RSLSDPCYYN KVDRTVYQFC SPSCWTKFQR TSPEGGIHLS CHYCHSLFSG
610 620 630 640 650
KPEVLDWQDQ VFQFCCRDCC EDFKRLRGVV SQCEHCRQEK LLHEKLRFSG
660 670 680 690 700
VEKSFCSEGC VLLYKQDFTK KLGLCCITCT YCSQTCQRGV TEQLDGSTWD
710 720 730 740 750
FCSEDCKSKY LLWYCKAARC HACKRQGKLL ETIHWRGQIR HFCNQQCLLR
760 770 780 790 800
FYSQQNQPNL DTQSGPESLL NSQSPESKPQ TPSQTKVENS NTVRTPEENG
810 820 830 840 850
NLGKIPVKTR SAPTAPTPPP PPPPATPRKN KAAMCKPLMQ NRGVSCKVEM
860 870 880 890 900
KSKGSQTEEW KPQVIVLPIP VPIFVPVPMH LYCQKVPVPF SMPIPVPVPM
910 920 930 940 950
FLPTTLESTD KIVETIEELK VKIPSNPLEA DILAMAEMIA EAEELDKASS
960 970 980 990 1000
DLCDLVSNQS AEGLLEDCDL FGPARDDVLA MAVKMANVLD EPGQDLEADF
1010 1020 1030 1040 1050
PKNPLDINPS VDFLFDCGLV GPEDVSTEQD LPRTMRKGQK RLVLSESCSR
1060 1070 1080 1090 1100
DSMSSQPSCT GLNYSYGVNA WKCWVQSKYA NGETSKGDEL RFGPKPMRIK
1110 1120 1130 1140 1150
EDILACSAAE LNYGLAQFVR EITRPNGERY EPDSIYYLCL GIQQYLLENN
1160 1170 1180 1190 1200
RMVNIFTDLY YLTFVQELNK SLSTWQPTLL PNNTVFSRVE EEHLWECKQL
1210 1220 1230 1240 1250
GVYSPFVLLN TLMFFNTKFF GLQTAEEHMQ LSFTNVVRQS RKCTTPRGTT
1260 1270 1280 1290 1300
KVVSIRYYAP VRQRKGRDTG PGKRKREDEA PILEQRENRM NPLRCPVKFY
1310 1320 1330 1340 1350
EFYLSKCPES LRTRNDVFYL QPERSCIAES PLWYSVIPMD RSMLESMLNR
1360 1370
ILAVREIYEE LGRPGEEDLD
Length:1,370
Mass (Da):152,379
Last modified:December 1, 2000 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i088B5E01E7EE9C30
GO
Isoform 2 (identifier: Q14202-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     793-804: Missing.

Show »
Length:1,358
Mass (Da):151,084
Checksum:i8B636620F05DF82F
GO
Isoform 3 (identifier: Q14202-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     491-495: KNTRV → VGPRE
     496-1370: Missing.

Show »
Length:495
Mass (Da):52,485
Checksum:iAC0D49C9F3D9CC15
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A6NHB5A6NHB5_HUMAN
Zinc finger MYM-type protein 3
ZMYM3
1,372Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A6NHN7A6NHN7_HUMAN
Zinc finger MYM-type protein 3
ZMYM3
1,280Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A6NL54A6NL54_HUMAN
Zinc finger MYM-type protein 3
ZMYM3
497Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A6NC58A6NC58_HUMAN
Zinc finger MYM-type protein 3
ZMYM3
349Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA20839 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_043262491 – 495KNTRV → VGPRE in isoform 3. 2 Publications5
Alternative sequenceiVSP_043263496 – 1370Missing in isoform 3. 2 PublicationsAdd BLAST875
Alternative sequenceiVSP_004492793 – 804Missing in isoform 2. 1 PublicationAdd BLAST12

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
X95808 mRNA Translation: CAA65075.1
AB002383 mRNA Translation: BAA20839.2 Different initiation.
BT007095 mRNA Translation: AAP35759.1
AL590762 Genomic DNA No translation available.
CH471132 Genomic DNA Translation: EAX05302.1
CH471132 Genomic DNA Translation: EAX05303.1
BC069057 mRNA Translation: AAH69057.1
BC013009 mRNA Translation: AAH13009.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS14409.1 [Q14202-1]
CCDS55443.1 [Q14202-3]
CCDS55444.1 [Q14202-2]

NCBI Reference Sequences

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RefSeqi
NP_001164633.1, NM_001171162.1 [Q14202-2]
NP_001164634.1, NM_001171163.1 [Q14202-3]
NP_005087.1, NM_005096.3 [Q14202-1]
NP_963893.1, NM_201599.2 [Q14202-1]
XP_005262366.1, XM_005262309.3 [Q14202-1]
XP_005262367.1, XM_005262310.2 [Q14202-2]
XP_011529364.1, XM_011531062.2 [Q14202-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000314425; ENSP00000322845; ENSG00000147130 [Q14202-1]
ENST00000373981; ENSP00000363093; ENSG00000147130 [Q14202-3]
ENST00000373998; ENSP00000363110; ENSG00000147130 [Q14202-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
9203

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:9203

UCSC genome browser

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UCSCi
uc004dzh.3 human [Q14202-1]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X95808 mRNA Translation: CAA65075.1
AB002383 mRNA Translation: BAA20839.2 Different initiation.
BT007095 mRNA Translation: AAP35759.1
AL590762 Genomic DNA No translation available.
CH471132 Genomic DNA Translation: EAX05302.1
CH471132 Genomic DNA Translation: EAX05303.1
BC069057 mRNA Translation: AAH69057.1
BC013009 mRNA Translation: AAH13009.1
CCDSiCCDS14409.1 [Q14202-1]
CCDS55443.1 [Q14202-3]
CCDS55444.1 [Q14202-2]
RefSeqiNP_001164633.1, NM_001171162.1 [Q14202-2]
NP_001164634.1, NM_001171163.1 [Q14202-3]
NP_005087.1, NM_005096.3 [Q14202-1]
NP_963893.1, NM_201599.2 [Q14202-1]
XP_005262366.1, XM_005262309.3 [Q14202-1]
XP_005262367.1, XM_005262310.2 [Q14202-2]
XP_011529364.1, XM_011531062.2 [Q14202-1]

3D structure databases

SMRiQ14202
ModBaseiSearch...

Protein-protein interaction databases

BioGridi114637, 71 interactors
CORUMiQ14202
IntActiQ14202, 38 interactors
MINTiQ14202
STRINGi9606.ENSP00000322845

PTM databases

iPTMnetiQ14202
PhosphoSitePlusiQ14202

Polymorphism and mutation databases

BioMutaiZMYM3
DMDMi12644413

Proteomic databases

EPDiQ14202
jPOSTiQ14202
MassIVEiQ14202
MaxQBiQ14202
PaxDbiQ14202
PeptideAtlasiQ14202
PRIDEiQ14202
ProteomicsDBi59922 [Q14202-1]
59923 [Q14202-2]
59924 [Q14202-3]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
9203

Genome annotation databases

EnsembliENST00000314425; ENSP00000322845; ENSG00000147130 [Q14202-1]
ENST00000373981; ENSP00000363093; ENSG00000147130 [Q14202-3]
ENST00000373998; ENSP00000363110; ENSG00000147130 [Q14202-2]
GeneIDi9203
KEGGihsa:9203
UCSCiuc004dzh.3 human [Q14202-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
9203
DisGeNETi9203

GeneCards: human genes, protein and diseases

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GeneCardsi
ZMYM3
HGNCiHGNC:13054 ZMYM3
HPAiHPA003211
HPA075255
MIMi300061 gene
neXtProtiNX_Q14202
OpenTargetsiENSG00000147130
PharmGKBiPA37632

Human Unidentified Gene-Encoded large proteins database

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HUGEi
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GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410IE8I Eukaryota
ENOG410XQR6 LUCA
GeneTreeiENSGT00940000160693
HOGENOMiCLU_004099_1_0_1
InParanoidiQ14202
OrthoDBi587724at2759
PhylomeDBiQ14202
TreeFamiTF336988

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ZMYM3 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
ZMYM3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
9203
PharosiQ14202 Tbio

Protein Ontology

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PROi
PR:Q14202
RNActiQ14202 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000147130 Expressed in left ovary and 224 other tissues
ExpressionAtlasiQ14202 baseline and differential
GenevisibleiQ14202 HS

Family and domain databases

InterProiView protein in InterPro
IPR021893 DUF3504
IPR011017 TRASH_dom
IPR010507 Znf_MYM
PfamiView protein in Pfam
PF12012 DUF3504, 1 hit
PF06467 zf-FCS, 8 hits
SMARTiView protein in SMART
SM00746 TRASH, 10 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZMYM3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q14202
Secondary accession number(s): D3DVV3, O15089, Q96E26
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: December 1, 2000
Last modified: February 26, 2020
This is version 165 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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