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Protein

Dihydropyrimidinase-related protein 1

Gene

CRMP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. May participate in cytokinesis.2 Publications

Caution

Lacks most of the conserved residues that are essential for binding the metal cofactor and hence for dihydropyrimidinase activity. Its enzyme activity is therefore unsure.Curated

GO - Molecular functioni

GO - Biological processi

  • axon guidance Source: InterPro
  • microtubule cytoskeleton organization Source: InterPro
  • negative regulation of actin filament binding Source: WormBase
  • negative regulation of neuron projection development Source: WormBase
  • nervous system development Source: ProtInc
  • nucleobase-containing compound metabolic process Source: ProtInc

Enzyme and pathway databases

ReactomeiR-HSA-399956 CRMPs in Sema3A signaling
SIGNORiQ14194

Protein family/group databases

MEROPSiM38.974

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydropyrimidinase-related protein 1
Short name:
DRP-1
Alternative name(s):
Collapsin response mediator protein 1
Short name:
CRMP-1
Unc-33-like phosphoprotein 3
Short name:
ULIP-3
Gene namesi
Name:CRMP1
Synonyms:DPYSL1, ULIP3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000072832.14
HGNCiHGNC:2365 CRMP1
MIMi602462 gene
neXtProtiNX_Q14194

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi101 – 102TT → AA: 2.5-fold increase in cells with a defect of cytokinesis. 1 Publication2

Organism-specific databases

DisGeNETi1400
OpenTargetsiENSG00000072832
PharmGKBiPA26885

Polymorphism and mutation databases

BioMutaiCRMP1
DMDMi3122031

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001659091 – 572Dihydropyrimidinase-related protein 1Add BLAST572

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei8PhosphoserineBy similarity1
Modified residuei101Phosphothreonine; by AURKA1 Publication1
Modified residuei102Phosphothreonine; by AURKA1 Publication1
Modified residuei316Nitrated tyrosineBy similarity1
Modified residuei504PhosphotyrosineBy similarity1
Modified residuei509PhosphothreonineBy similarity1
Modified residuei521PhosphoserineBy similarity1
Modified residuei522PhosphoserineBy similarity1
Modified residuei537PhosphoserineBy similarity1
Modified residuei540PhosphoserineBy similarity1
Modified residuei542PhosphoserineBy similarity1

Keywords - PTMi

Nitration, Phosphoprotein

Proteomic databases

EPDiQ14194
MaxQBiQ14194
PaxDbiQ14194
PeptideAtlasiQ14194
PRIDEiQ14194
ProteomicsDBi59915
59916 [Q14194-2]

PTM databases

iPTMnetiQ14194
PhosphoSitePlusiQ14194

Expressioni

Tissue specificityi

Brain.

Gene expression databases

BgeeiENSG00000072832 Expressed in 177 organ(s), highest expression level in frontal cortex
CleanExiHS_CRMP1
ExpressionAtlasiQ14194 baseline and differential
GenevisibleiQ14194 HS

Organism-specific databases

HPAiCAB037313
HPA035640

Interactioni

Subunit structurei

Homotetramer, and heterotetramer with DPYSL2, DPYSL3, DPYSL4 or DPYSL5. Interacts with PLXNA1 (By similarity).By similarity

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi107790, 108 interactors
CORUMiQ14194
IntActiQ14194, 75 interactors
MINTiQ14194
STRINGi9606.ENSP00000321606

Structurei

Secondary structure

1572
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ14194
SMRiQ14194
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2584 Eukaryota
COG0044 LUCA
GeneTreeiENSGT00760000119241
HOGENOMiHOG000219145
HOVERGENiHBG000806
InParanoidiQ14194
OMAiPEYLYQR
PhylomeDBiQ14194
TreeFamiTF314706

Family and domain databases

CDDicd01314 D-HYD, 1 hit
Gene3Di2.30.40.10, 1 hit
InterProiView protein in InterPro
IPR006680 Amidohydro-rel
IPR030624 CRMP1
IPR011778 Hydantoinase/dihydroPyrase
IPR011059 Metal-dep_hydrolase_composite
IPR032466 Metal_Hydrolase
PANTHERiPTHR11647:SF54 PTHR11647:SF54, 1 hit
PfamiView protein in Pfam
PF01979 Amidohydro_1, 1 hit
SUPFAMiSSF51338 SSF51338, 2 hits
SSF51556 SSF51556, 1 hit
TIGRFAMsiTIGR02033 D-hydantoinase, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q14194-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSYQGKKSIP HITSDRLLIK GGRIINDDQS LYADVYLEDG LIKQIGENLI
60 70 80 90 100
VPGGVKTIEA NGRMVIPGGI DVNTYLQKPS QGMTAADDFF QGTRAALVGG
110 120 130 140 150
TTMIIDHVVP EPGSSLLTSF EKWHEAADTK SCCDYSLHVD ITSWYDGVRE
160 170 180 190 200
ELEVLVQDKG VNSFQVYMAY KDVYQMSDSQ LYEAFTFLKG LGAVILVHAE
210 220 230 240 250
NGDLIAQEQK RILEMGITGP EGHALSRPEE LEAEAVFRAI TIAGRINCPV
260 270 280 290 300
YITKVMSKSA ADIIALARKK GPLVFGEPIA ASLGTDGTHY WSKNWAKAAA
310 320 330 340 350
FVTSPPLSPD PTTPDYLTSL LACGDLQVTG SGHCPYSTAQ KAVGKDNFTL
360 370 380 390 400
IPEGVNGIEE RMTVVWDKAV ATGKMDENQF VAVTSTNAAK IFNLYPRKGR
410 420 430 440 450
IAVGSDADVV IWDPDKLKTI TAKSHKSAVE YNIFEGMECH GSPLVVISQG
460 470 480 490 500
KIVFEDGNIN VNKGMGRFIP RKAFPEHLYQ RVKIRNKVFG LQGVSRGMYD
510 520 530 540 550
GPVYEVPATP KYATPAPSAK SSPSKHQPPP IRNLHQSNFS LSGAQIDDNN
560 570
PRRTGHRIVA PPGGRSNITS LG
Length:572
Mass (Da):62,184
Last modified:November 1, 1996 - v1
Checksum:iA5385FCC79328A30
GO
Isoform LCRMP-1 (identifier: Q14194-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-13: MSYQGKKSIPHIT → MADRRRAWNT...DLPLGRDNGQ

Show »
Length:686
Mass (Da):74,262
Checksum:i2C897F656E5F34FA
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PD68E9PD68_HUMAN
Dihydropyrimidinase-related protein...
CRMP1
570Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti351 – 370Missing in AAK55500 (PubMed:10048489).CuratedAdd BLAST20
Sequence conflicti504Y → H in AAA93201 (PubMed:7637782).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_037745461V → I. Corresponds to variant dbSNP:rs34611001Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0425451 – 13MSYQG…IPHIT → MADRRRAWNTEDDLPVYLAR PGSAAQTPRQKYGGMFAAVE GAYENKTIDFDAYSVGRRGS ARTPRSAGRPDAVGLPGPGG SEDTASDVSEPSGSAVSSPG ERDERPPTLRIRRPAPRDLP LGRDNGQ in isoform LCRMP-1. 1 PublicationAdd BLAST13

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D78012 mRNA Translation: BAA11190.1
DQ206871 mRNA Translation: ABB22046.1
BT006806 mRNA Translation: AAP35452.1
AC105915 Genomic DNA Translation: AAY40959.1
CH471131 Genomic DNA Translation: EAW82405.1
CH471131 Genomic DNA Translation: EAW82407.1
BC000252 mRNA Translation: AAH00252.1
BC007613 mRNA Translation: AAH07613.1
AH010780 Genomic DNA Translation: AAK55500.1
U17278 mRNA Translation: AAA93201.1
CCDSiCCDS33950.1 [Q14194-2]
CCDS43207.1 [Q14194-1]
PIRiJC5316
RefSeqiNP_001014809.1, NM_001014809.2 [Q14194-2]
NP_001275590.1, NM_001288661.1
NP_001275591.1, NM_001288662.1
NP_001304.1, NM_001313.4 [Q14194-1]
UniGeneiHs.135270

Genome annotation databases

EnsembliENST00000324989; ENSP00000321606; ENSG00000072832 [Q14194-2]
ENST00000397890; ENSP00000380987; ENSG00000072832 [Q14194-1]
GeneIDi1400
KEGGihsa:1400
UCSCiuc003giq.5 human [Q14194-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D78012 mRNA Translation: BAA11190.1
DQ206871 mRNA Translation: ABB22046.1
BT006806 mRNA Translation: AAP35452.1
AC105915 Genomic DNA Translation: AAY40959.1
CH471131 Genomic DNA Translation: EAW82405.1
CH471131 Genomic DNA Translation: EAW82407.1
BC000252 mRNA Translation: AAH00252.1
BC007613 mRNA Translation: AAH07613.1
AH010780 Genomic DNA Translation: AAK55500.1
U17278 mRNA Translation: AAA93201.1
CCDSiCCDS33950.1 [Q14194-2]
CCDS43207.1 [Q14194-1]
PIRiJC5316
RefSeqiNP_001014809.1, NM_001014809.2 [Q14194-2]
NP_001275590.1, NM_001288661.1
NP_001275591.1, NM_001288662.1
NP_001304.1, NM_001313.4 [Q14194-1]
UniGeneiHs.135270

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4B3ZX-ray3.05A/B/C/D1-572[»]
ProteinModelPortaliQ14194
SMRiQ14194
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107790, 108 interactors
CORUMiQ14194
IntActiQ14194, 75 interactors
MINTiQ14194
STRINGi9606.ENSP00000321606

Protein family/group databases

MEROPSiM38.974

PTM databases

iPTMnetiQ14194
PhosphoSitePlusiQ14194

Polymorphism and mutation databases

BioMutaiCRMP1
DMDMi3122031

Proteomic databases

EPDiQ14194
MaxQBiQ14194
PaxDbiQ14194
PeptideAtlasiQ14194
PRIDEiQ14194
ProteomicsDBi59915
59916 [Q14194-2]

Protocols and materials databases

DNASUi1400
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000324989; ENSP00000321606; ENSG00000072832 [Q14194-2]
ENST00000397890; ENSP00000380987; ENSG00000072832 [Q14194-1]
GeneIDi1400
KEGGihsa:1400
UCSCiuc003giq.5 human [Q14194-1]

Organism-specific databases

CTDi1400
DisGeNETi1400
EuPathDBiHostDB:ENSG00000072832.14
GeneCardsiCRMP1
HGNCiHGNC:2365 CRMP1
HPAiCAB037313
HPA035640
MIMi602462 gene
neXtProtiNX_Q14194
OpenTargetsiENSG00000072832
PharmGKBiPA26885
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2584 Eukaryota
COG0044 LUCA
GeneTreeiENSGT00760000119241
HOGENOMiHOG000219145
HOVERGENiHBG000806
InParanoidiQ14194
OMAiPEYLYQR
PhylomeDBiQ14194
TreeFamiTF314706

Enzyme and pathway databases

ReactomeiR-HSA-399956 CRMPs in Sema3A signaling
SIGNORiQ14194

Miscellaneous databases

ChiTaRSiCRMP1 human
GeneWikiiCRMP1
GenomeRNAii1400
PROiPR:Q14194
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000072832 Expressed in 177 organ(s), highest expression level in frontal cortex
CleanExiHS_CRMP1
ExpressionAtlasiQ14194 baseline and differential
GenevisibleiQ14194 HS

Family and domain databases

CDDicd01314 D-HYD, 1 hit
Gene3Di2.30.40.10, 1 hit
InterProiView protein in InterPro
IPR006680 Amidohydro-rel
IPR030624 CRMP1
IPR011778 Hydantoinase/dihydroPyrase
IPR011059 Metal-dep_hydrolase_composite
IPR032466 Metal_Hydrolase
PANTHERiPTHR11647:SF54 PTHR11647:SF54, 1 hit
PfamiView protein in Pfam
PF01979 Amidohydro_1, 1 hit
SUPFAMiSSF51338 SSF51338, 2 hits
SSF51556 SSF51556, 1 hit
TIGRFAMsiTIGR02033 D-hydantoinase, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDPYL1_HUMAN
AccessioniPrimary (citable) accession number: Q14194
Secondary accession number(s): A0EJG6
, Q13024, Q4W5F1, Q96TC8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: November 7, 2018
This is version 181 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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