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UniProtKB - Q14192 (FHL2_HUMAN)

Entry version 203 (02 Jun 2021)
Sequence version 3 (17 Oct 2006)
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Protein

Four and a half LIM domains protein 2

Gene

FHL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May function as a molecular transmitter linking various signaling pathways to transcriptional regulation. Negatively regulates the transcriptional repressor E4F1 and may function in cell growth. Inhibits the transcriptional activity of FOXO1 and its apoptotic function by enhancing the interaction of FOXO1 with SIRT1 and FOXO1 deacetylation. Negatively regulates the calcineurin/NFAT signaling pathway in cardiomyocytes (PubMed:28717008).

4 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri7 – 31C4-typeSequence analysisAdd BLAST25

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q14192

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-1989781, PPARA activates gene expression

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q14192

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Four and a half LIM domains protein 2
Short name:
FHL-2
Alternative name(s):
LIM domain protein DRAL
Skeletal muscle LIM-protein 3
Short name:
SLIM-3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FHL2
Synonyms:DRAL, SLIM3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:3703, FHL2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		602633, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q14192

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000115641.18

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		2274

MalaCards human disease database

More...MalaCardsi		FHL2

Open Targets

More...OpenTargetsi		ENSG00000115641

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		154, Familial isolated dilated cardiomyopathy

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA164

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q14192, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		FHL2

Domain mapping of disease mutations (DMDM)

More...DMDMi		116241364

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000757371 – 279Four and a half LIM domains protein 2Add BLAST279

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki78Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki167Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki220Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei238PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q14192

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q14192

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q14192

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q14192

PeptideAtlas

More...PeptideAtlasi		Q14192

PRoteomics IDEntifications database

More...PRIDEi		Q14192

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		59914 [Q14192-1]
65204

2D gel databases

University College Dublin 2-DE Proteome Database

More...UCD-2DPAGEi		Q14192

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q14192

MetOSite database of methionine sulfoxide sites

More...MetOSitei		Q14192

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q14192

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q14192

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in skeletal muscle and heart.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000115641, Expressed in myocardium and 226 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q14192, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q14192, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000115641, Group enriched (heart muscle, ovary)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with ZNF638 and TTN/titin (PubMed:11813260, PubMed:12432079).

Interacts with E4F1 (PubMed:16652157).

Interacts with GRB7 (PubMed:18853468).

Interacts with SIRT1 and FOXO1 (PubMed:15692560).

Interacts with CEFIP (PubMed:28717008).

Interacts with calcineurin (By similarity).

Interacts with FOXK1 (By similarity).

By similarity6 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q14192
With#Exp.IntAct
A1CF [Q9NQ94]3EBI-701903,EBI-2809489
ABI1 - isoform 5 [Q8IZP0-5]3EBI-701903,EBI-11743294
ABLIM1 - isoform 4 [O14639-4]3EBI-701903,EBI-11030084
AKIP1 [Q9NQ31]3EBI-701903,EBI-517035
AMOT [A2BDD9]3EBI-701903,EBI-17286414
ANKRD55 [Q3KP44]3EBI-701903,EBI-14493093
ARHGAP9 [Q9BRR9]3EBI-701903,EBI-750254
ATF3 [P18847]3EBI-701903,EBI-712767
BANP [A0A0S2Z5G4]3EBI-701903,EBI-16429704
BANP [B4DE54]4EBI-701903,EBI-16429313
BANP [Q8N9N5]5EBI-701903,EBI-744695
BANP - isoform 2 [Q8N9N5-2]6EBI-701903,EBI-11524452
BANP - isoform 7 [Q8N9N5-7]3EBI-701903,EBI-16429296
BARX2 [Q9UMQ3]3EBI-701903,EBI-12053927
BLZF1 [Q9H2G9]10EBI-701903,EBI-2548012
BRCA1 [P38398]6EBI-701903,EBI-349905
C20orf85 [Q9H1P6]3EBI-701903,EBI-12155483
C2CD6 [Q53TS8]3EBI-701903,EBI-739879
CAND2 [O75155]3EBI-701903,EBI-5656182
CCDC198 [E9PSE9]3EBI-701903,EBI-11748295
CCDC92 [Q53HC0]10EBI-701903,EBI-719994
CSN2 [P05814]4EBI-701903,EBI-1642112
CSN2 [W5RWE1]3EBI-701903,EBI-10330381
DAPL1 [A0PJW8]3EBI-701903,EBI-12840152
DCP1A [Q9NPI6]10EBI-701903,EBI-374238
DDIT4L [Q96D03]3EBI-701903,EBI-742054
DEAF1 [O75398]3EBI-701903,EBI-718185
DLGAP1 [Q6IS01]3EBI-701903,EBI-11961832
DTX2 [Q86UW9]6EBI-701903,EBI-740376
FAM204A [Q9H8W3]3EBI-701903,EBI-8465160
FAM214B [Q7L5A3]3EBI-701903,EBI-745689
itself3EBI-701903,EBI-701903
FOXO1 [Q12778]8EBI-701903,EBI-1108782
GAS8 [O95995]3EBI-701903,EBI-1052570
GATAD2B [Q8WXI9]3EBI-701903,EBI-923440
GLYR1 [Q49A26]4EBI-701903,EBI-2804292
GLYR1 - isoform 4 [Q49A26-4]3EBI-701903,EBI-12143817
GMEB2 [Q9UKD1]3EBI-701903,EBI-948296
GNG12 [Q9UBI6]11EBI-701903,EBI-358636
GNG4 [P50150]3EBI-701903,EBI-6395970
GOLGA6A [Q9NYA3]3EBI-701903,EBI-11163335
GTF2F2 [P13984]3EBI-701903,EBI-1030560
GTF2H1 [P32780]3EBI-701903,EBI-715539
HCFC1 - isoform 1 [P51610-1]5EBI-701903,EBI-396188
hCG_1987119 [A0A024R8L2]5EBI-701903,EBI-14103818
HSF2BP [O75031]3EBI-701903,EBI-7116203
ID3 [Q02535]4EBI-701903,EBI-1387094
IFI35 - isoform 2 [P80217-2]5EBI-701903,EBI-12823003
IKZF1 - isoform Ik7 [Q13422-7]3EBI-701903,EBI-11522367
IL16 - isoform 2 [Q14005-2]3EBI-701903,EBI-17178971
INCA1 [Q0VD86]5EBI-701903,EBI-6509505
JUP [P14923]7EBI-701903,EBI-702484
KANK2 [Q63ZY3]6EBI-701903,EBI-2556193
KIAA1217 - isoform 6 [Q5T5P2-6]3EBI-701903,EBI-10188326
KIF5B [P33176]3EBI-701903,EBI-355878
KLF12 [Q9Y4X4]3EBI-701903,EBI-750750
KPRP [Q5T749]3EBI-701903,EBI-10981970
LDLRAP1 [Q5SW96]3EBI-701903,EBI-747813
LRIF1 [Q5T3J3]3EBI-701903,EBI-473196
MAGEL2 [Q9UJ55]3EBI-701903,EBI-5668174
MBD3L1 [Q8WWY6]3EBI-701903,EBI-12516603
MISP [Q8IVT2]3EBI-701903,EBI-2555085
NIBAN1 [Q9BZQ8]6EBI-701903,EBI-6916466
NRF1 [Q16656]3EBI-701903,EBI-2547810
NRF1 - isoform 4 [Q16656-4]3EBI-701903,EBI-11742836
PHF1 [O43189]3EBI-701903,EBI-530034
PHF21A [Q96BD5]3EBI-701903,EBI-745085
PICALM [Q13492]8EBI-701903,EBI-2803688
PKNOX1 [P55347]3EBI-701903,EBI-1373569
PKNOX2 [Q96KN3]3EBI-701903,EBI-2692890
POGZ [Q7Z3K3]3EBI-701903,EBI-1389308
POU6F2 [P78424]3EBI-701903,EBI-12029004
PPP1R32 - isoform 2 [Q7Z5V6-2]3EBI-701903,EBI-12000762
PRDM11 [Q9NQV5]3EBI-701903,EBI-12941246
PRDM6 [Q9NQX0]3EBI-701903,EBI-11320284
PRR5L [Q6MZQ0]3EBI-701903,EBI-1567866
QRICH1 [Q2TAL8]3EBI-701903,EBI-2798044
RAI2 [Q9Y5P3]7EBI-701903,EBI-746228
RASL12 [Q9NYN1]4EBI-701903,EBI-12917066
REL [Q04864]3EBI-701903,EBI-307352
RFX3 [P48380]10EBI-701903,EBI-742557
RIPPLY1 [Q0D2K3]3EBI-701903,EBI-10226430
SAXO1 [Q8IYX7]4EBI-701903,EBI-3957636
SAXO2 [Q658L1]3EBI-701903,EBI-18394432
SCNM1 [Q9BWG6]3EBI-701903,EBI-748391
SIGLEC6 [O43699]3EBI-701903,EBI-2814604
SIRT1 [Q96EB6]2EBI-701903,EBI-1802965
SLAIN1 [Q8ND83]3EBI-701903,EBI-10269374
SNAI1 [O95863]3EBI-701903,EBI-1045459
SOX30 [O94993]3EBI-701903,EBI-742973
SP2 [Q02086]3EBI-701903,EBI-8651703
SP2 - isoform 2 [Q02086-2]3EBI-701903,EBI-9088579
SPHK1 [Q9NYA1]7EBI-701903,EBI-985303
SPRY4 [Q9C004]3EBI-701903,EBI-354861
SREBF2 [Q12772]3EBI-701903,EBI-465059
TCP10L [Q8TDR4]3EBI-701903,EBI-3923210
TRIM74 - isoform 2 [Q86UV6-2]3EBI-701903,EBI-10259086
TXNRD3NB [Q6F5E7]3EBI-701903,EBI-18122152
VXN [Q8TAG6]3EBI-701903,EBI-12071548
YY1 [P25490]5EBI-701903,EBI-765538
ZFP64 [Q9NTW7]8EBI-701903,EBI-711679
ZMYM4 [Q5VZL5]3EBI-701903,EBI-2514659
ZNF131 - isoform 2 [P52739-2]6EBI-701903,EBI-10213055
ZNF143 [P52747]3EBI-701903,EBI-2849334
ZNF200 [P98182]3EBI-701903,EBI-3913354
ZNF23 [P17027]3EBI-701903,EBI-5657766
ZNF408 [Q9H9D4]3EBI-701903,EBI-347633
ZNF410 - isoform 3 [Q86VK4-3]3EBI-701903,EBI-11741890
ZNF417 [Q8TAU3]3EBI-701903,EBI-740727
ZNF620 [Q6ZNG0]3EBI-701903,EBI-4395669
ZNF655 [Q8N720]3EBI-701903,EBI-625509
ZNF76 [P36508]3EBI-701903,EBI-7254550
ZNF85 [Q49A12]3EBI-701903,EBI-18141506
ZSCAN9 [O15535]3EBI-701903,EBI-751531
Trim54 [Q9ERP3] from Mus musculus.2EBI-701903,EBI-15626796

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		108565, 250 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q14192

Database of interacting proteins

More...DIPi		DIP-5980N

Protein interaction database and analysis system

More...IntActi		Q14192, 209 interactors

Molecular INTeraction database

More...MINTi		Q14192

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000386665

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q14192, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1279
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q14192

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q14192

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini40 – 92LIM zinc-binding 1PROSITE-ProRule annotationAdd BLAST53
Domaini101 – 153LIM zinc-binding 2PROSITE-ProRule annotationAdd BLAST53
Domaini162 – 212LIM zinc-binding 3PROSITE-ProRule annotationAdd BLAST51
Domaini221 – 275LIM zinc-binding 4PROSITE-ProRule annotationAdd BLAST55

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The third LIM zinc-binding mediates interaction with E4F1.1 Publication

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri7 – 31C4-typeSequence analysisAdd BLAST25

Keywords - Domaini

LIM domain, Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1704, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00950000183028

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_001357_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q14192

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q14192

TreeFam database of animal gene trees

More...TreeFami		TF321684

Family and domain databases

Intrinsically Disordered proteins with Extensive Annotations and Literature

More...IDEALi		IID00473

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR037987, FHL2/3/5
IPR001781, Znf_LIM

The PANTHER Classification System

More...PANTHERi		PTHR24205, PTHR24205, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00412, LIM, 4 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00132, LIM, 4 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00478, LIM_DOMAIN_1, 4 hits
PS50023, LIM_DOMAIN_2, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q14192-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTERFDCHHC NESLFGKKYI LREESPYCVV CFETLFANTC EECGKPIGCD 
        60         70         80         90        100
CKDLSYKDRH WHEACFHCSQ CRNSLVDKPF AAKEDQLLCT DCYSNEYSSK 
       110        120        130        140        150
CQECKKTIMP GTRKMEYKGS SWHETCFICH RCQQPIGTKS FIPKDNQNFC 
       160        170        180        190        200
VPCYEKQHAM QCVQCKKPIT TGGVTYREQP WHKECFVCTA CRKQLSGQRF 
       210        220        230        240        250
TARDDFAYCL NCFCDLYAKK CAGCTNPISG LGGTKYISFE ERQWHNDCFN 
       260        270 
CKKCSLSLVG RGFLTERDDI LCPDCGKDI
Length:279
Mass (Da):32,193
Last modified:October 17, 2006 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE94E3A7F6601F9F3
GO
Isoform 2 (identifier: Q14192-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     53-151: DLSYKDRHWH...IPKDNQNFCV → VPARWSTRAA...SQLAMTLPTA
     152-279: Missing.

Show »
Length:151
Mass (Da):15,890
Checksum:i72F31D2DB830DB20
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8WDA8F8WDA8_HUMAN
Four and a half LIM domains protein...
FHL2
54Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
U3KQT4U3KQT4_HUMAN
Four and a half LIM domains protein...
FHL2
65Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J3S8C9J3S8_HUMAN
Four and a half LIM domains protein...
FHL2
19Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_067455167K → M3 Publications1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_05699953 – 151DLSYK…QNFCV → VPARWSTRAAAGMRPASSAT AASSQLEPRVSSPKTIRISV CPAMRNNMPCSAFSAKSPSP REGSLTGSSPGTRSASCAPP AGSSCLGSASQLAMTLPTA in isoform 2. 1 PublicationAdd BLAST99
Alternative sequenceiVSP_057000152 – 279Missing in isoform 2. 1 PublicationAdd BLAST128

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
L42176 mRNA Translation: AAA85333.1
U29332 mRNA Translation: AAC52073.1
AB038794 Genomic DNA Translation: BAA92253.1
AB158503 mRNA Translation: BAD69710.1
DQ307067 mRNA Translation: ABC25549.1
AC012360 Genomic DNA No translation available.
AC068273 Genomic DNA No translation available.
AC108058 Genomic DNA No translation available.
BC014397 mRNA Translation: AAH14397.1
U60117 mRNA Translation: AAC50794.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS2070.1 [Q14192-1]

Protein sequence database of the Protein Information Resource

More...PIRi		JC6565

NCBI Reference Sequences

More...RefSeqi		NP_001034581.1, NM_001039492.2 [Q14192-1]
NP_001305823.1, NM_001318894.1 [Q14192-1]
NP_001305824.1, NM_001318895.1 [Q14192-1]
NP_001305825.1, NM_001318896.1 [Q14192-1]
NP_001305826.1, NM_001318897.1
NP_001441.4, NM_001450.3 [Q14192-1]
NP_963849.1, NM_201555.1 [Q14192-1]
NP_963851.2, NM_201557.3 [Q14192-1]
XP_011509100.1, XM_011510798.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000322142; ENSP00000322909; ENSG00000115641 [Q14192-1]
ENST00000344213; ENSP00000344266; ENSG00000115641 [Q14192-1]
ENST00000358129; ENSP00000350846; ENSG00000115641 [Q14192-2]
ENST00000393352; ENSP00000377020; ENSG00000115641 [Q14192-1]
ENST00000393353; ENSP00000377021; ENSG00000115641 [Q14192-1]
ENST00000408995; ENSP00000386633; ENSG00000115641 [Q14192-1]
ENST00000409177; ENSP00000386892; ENSG00000115641 [Q14192-1]
ENST00000409807; ENSP00000386665; ENSG00000115641 [Q14192-1]
ENST00000530340; ENSP00000433567; ENSG00000115641 [Q14192-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		2274

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:2274

UCSC genome browser

More...UCSCi		uc061mpc.1, human [Q14192-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42176 mRNA Translation: AAA85333.1
U29332 mRNA Translation: AAC52073.1
AB038794 Genomic DNA Translation: BAA92253.1
AB158503 mRNA Translation: BAD69710.1
DQ307067 mRNA Translation: ABC25549.1
AC012360 Genomic DNA No translation available.
AC068273 Genomic DNA No translation available.
AC108058 Genomic DNA No translation available.
BC014397 mRNA Translation: AAH14397.1
U60117 mRNA Translation: AAC50794.1
CCDSiCCDS2070.1 [Q14192-1]
PIRiJC6565
RefSeqiNP_001034581.1, NM_001039492.2 [Q14192-1]
NP_001305823.1, NM_001318894.1 [Q14192-1]
NP_001305824.1, NM_001318895.1 [Q14192-1]
NP_001305825.1, NM_001318896.1 [Q14192-1]
NP_001305826.1, NM_001318897.1
NP_001441.4, NM_001450.3 [Q14192-1]
NP_963849.1, NM_201555.1 [Q14192-1]
NP_963851.2, NM_201557.3 [Q14192-1]
XP_011509100.1, XM_011510798.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1X4KNMR-A101-159[»]
1X4LNMR-A221-279[»]
2D8ZNMR-A162-218[»]
2MIUNMR-A1-98[»]
SMRiQ14192
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi108565, 250 interactors
CORUMiQ14192
DIPiDIP-5980N
IntActiQ14192, 209 interactors
MINTiQ14192
STRINGi9606.ENSP00000386665

PTM databases

iPTMnetiQ14192
MetOSiteiQ14192
PhosphoSitePlusiQ14192
SwissPalmiQ14192

Genetic variation databases

BioMutaiFHL2
DMDMi116241364

2D gel databases

UCD-2DPAGEiQ14192

Proteomic databases

EPDiQ14192
jPOSTiQ14192
MassIVEiQ14192
PaxDbiQ14192
PeptideAtlasiQ14192
PRIDEiQ14192
ProteomicsDBi59914 [Q14192-1]
65204

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		949, 345 antibodies

The DNASU plasmid repository

More...DNASUi		2274

Genome annotation databases

EnsembliENST00000322142; ENSP00000322909; ENSG00000115641 [Q14192-1]
ENST00000344213; ENSP00000344266; ENSG00000115641 [Q14192-1]
ENST00000358129; ENSP00000350846; ENSG00000115641 [Q14192-2]
ENST00000393352; ENSP00000377020; ENSG00000115641 [Q14192-1]
ENST00000393353; ENSP00000377021; ENSG00000115641 [Q14192-1]
ENST00000408995; ENSP00000386633; ENSG00000115641 [Q14192-1]
ENST00000409177; ENSP00000386892; ENSG00000115641 [Q14192-1]
ENST00000409807; ENSP00000386665; ENSG00000115641 [Q14192-1]
ENST00000530340; ENSP00000433567; ENSG00000115641 [Q14192-1]
GeneIDi2274
KEGGihsa:2274
UCSCiuc061mpc.1, human [Q14192-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		2274
DisGeNETi2274

GeneCards: human genes, protein and diseases

More...GeneCardsi		FHL2
HGNCiHGNC:3703, FHL2
HPAiENSG00000115641, Group enriched (heart muscle, ovary)
MalaCardsiFHL2
MIMi602633, gene
neXtProtiNX_Q14192
OpenTargetsiENSG00000115641
Orphaneti154, Familial isolated dilated cardiomyopathy
PharmGKBiPA164
VEuPathDBiHostDB:ENSG00000115641.18

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1704, Eukaryota
GeneTreeiENSGT00950000183028
HOGENOMiCLU_001357_2_0_1
InParanoidiQ14192
PhylomeDBiQ14192
TreeFamiTF321684

Enzyme and pathway databases

PathwayCommonsiQ14192
ReactomeiR-HSA-1989781, PPARA activates gene expression
SIGNORiQ14192

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		2274, 9 hits in 1004 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		FHL2, human
EvolutionaryTraceiQ14192

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		FHL2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		2274
PharosiQ14192, Tbio

Protein Ontology

More...PROi		PR:Q14192
RNActiQ14192, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000115641, Expressed in myocardium and 226 other tissues
ExpressionAtlasiQ14192, baseline and differential
GenevisibleiQ14192, HS

Family and domain databases

IDEALiIID00473
InterProiView protein in InterPro
IPR037987, FHL2/3/5
IPR001781, Znf_LIM
PANTHERiPTHR24205, PTHR24205, 1 hit
PfamiView protein in Pfam
PF00412, LIM, 4 hits
SMARTiView protein in SMART
SM00132, LIM, 4 hits
PROSITEiView protein in PROSITE
PS00478, LIM_DOMAIN_1, 4 hits
PS50023, LIM_DOMAIN_2, 4 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFHL2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q14192
Secondary accession number(s): Q13229
, Q13644, Q2I5I4, Q5TM15, Q9P294
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: October 17, 2006
Last modified: June 2, 2021
This is version 203 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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