FHL2

Functionⁱ

May function as a molecular transmitter linking various signaling pathways to transcriptional regulation. Negatively regulates the transcriptional repressor E4F1 and may function in cell growth. Inhibits the transcriptional activity of FOXO1 and its apoptotic function by enhancing the interaction of FOXO1 with SIRT1 and FOXO1 deacetylation. Negatively regulates the calcineurin/NFAT signaling pathway in cardiomyocytes (PubMed:28717008).4 Publications

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	7 – 31	C4-typeSequence analysisAdd BLAST		25

GO - Molecular functionⁱ

androgen receptor binding
Source: UniProtKB
Non-traceable author statementⁱ
- 15572661
identical protein binding
Source: IntAct
Inferred from physical interactionⁱ
- 10906324
- 18255255
metal ion binding Source: UniProtKB-KW
transcription coactivator activity
Source: UniProtKB
Non-traceable author statementⁱ
- 15572661
transcription factor binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 15692560

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

androgen receptor signaling pathway
Source: UniProtKB
Non-traceable author statementⁱ
- 15572661
atrial cardiac muscle cell development Source: Ensembl
heart trabecula formation Source: Ensembl
negative regulation of apoptotic process
Source: UniProtKB
Inferred from direct assayⁱ
- 15692560
negative regulation of calcineurin-NFAT signaling cascade
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 22851699
negative regulation of transcription by RNA polymerase II
Source: UniProtKB
Inferred from direct assayⁱ
- 15692560
osteoblast differentiation Source: Ensembl
positive regulation of transcription, DNA-templated
Source: UniProtKB
Non-traceable author statementⁱ
- 15572661
regulation of lipid metabolic process Source: Reactome
response to hormone
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 17975004
ventricular cardiac muscle cell development Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Transcription, Transcription regulation
Ligand	Metal-binding, Zinc

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1989781 PPARA activates gene expression
SIGNORⁱ	Q14192

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Four and a half LIM domains protein 2 Short name: FHL-2 Alternative name(s): LIM domain protein DRAL Skeletal muscle LIM-protein 3 Short name: SLIM-3
Gene namesⁱ	Name:FHL2 Synonyms:DRAL, SLIM3
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 2

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000115641.18
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:3703 FHL2
MIMⁱ	602633 gene
neXtProtⁱ	NX_Q14192

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	2274
MalaCards human disease database More...MalaCardsⁱ	FHL2
Open Targets More...OpenTargetsⁱ	ENSG00000115641
Orphanetⁱ	154 Familial isolated dilated cardiomyopathy
PharmGKBⁱ	PA164

Polymorphism and mutation databases

BioMutaⁱ	FHL2
DMDMⁱ	116241364

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000075737	1 – 279	Four and a half LIM domains protein 2Add BLAST		279

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Cross-linkⁱ	78	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	167	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	220	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	238	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	Q14192
PaxDbⁱ	Q14192
PeptideAtlas More...PeptideAtlasⁱ	Q14192
PRIDEⁱ	Q14192
ProteomicsDBⁱ	59914

2D gel databases

UCD-2DPAGEⁱ	Q14192

UCD-2DPAGEⁱ

Q14192

PTM databases

iPTMnetⁱ	Q14192
PhosphoSitePlusⁱ	Q14192
SwissPalmⁱ	Q14192

Expressionⁱ

Tissue specificityⁱ

Expressed in skeletal muscle and heart.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000115641 Expressed in 215 organ(s), highest expression level in myocardium
CleanExⁱ	HS_FHL2
ExpressionAtlasⁱ	Q14192 baseline and differential
Genevisibleⁱ	Q14192 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB008368 HPA005922 HPA006028

HPAⁱ

CAB008368
HPA005922
HPA006028

Interactionⁱ

Subunit structureⁱ

Interacts with ZNF638 and TTN/titin. Interacts with E4F1. Interacts with GRB7. Interacts with SIRT1 and FOXO1. Interacts with CEFIP (PubMed:28717008). Interacts with calcineurin (By similarity).By similarity6 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
itself		3	EBI-701903,EBI-701903
ARHGAP9	Q9BRR9	3	EBI-701903,EBI-750254
ATF3	P18847	3	EBI-701903,EBI-712767
BANP	A0A0S2Z5G4	3	EBI-701903,EBI-16429704
BANP	B4DE54	4	EBI-701903,EBI-16429313
BANP	Q8N9N5	3	EBI-701903,EBI-744695
BANP	Q8N9N5-2	5	EBI-701903,EBI-11524452
BANP	Q8N9N5-7	3	EBI-701903,EBI-16429296
BLZF1	Q9H2G9	5	EBI-701903,EBI-2548012
BRCA1	P38398	6	EBI-701903,EBI-349905
CCDC92	Q53HC0	9	EBI-701903,EBI-719994
CSN2	W5RWE1	3	EBI-701903,EBI-10330381
DCP1A	Q9NPI6	5	EBI-701903,EBI-374238
DTX2	Q86UW9	6	EBI-701903,EBI-740376
FAM129A	Q9BZQ8	5	EBI-701903,EBI-6916466
FOXO1	Q12778	8	EBI-701903,EBI-1108782
GLYR1	Q49A26	3	EBI-701903,EBI-2804292
GMEB2	Q9UKD1	4	EBI-701903,EBI-948296
GNG12	Q9UBI6	6	EBI-701903,EBI-358636
HCFC1	P51610-1	5	EBI-701903,EBI-396188
INCA1	Q0VD86	3	EBI-701903,EBI-6509505
JUP	P14923	5	EBI-701903,EBI-702484
KANK2	Q63ZY3	5	EBI-701903,EBI-2556193
KIAA1217	Q5T5P2-6	3	EBI-701903,EBI-10188326
NRF1	Q16656	3	EBI-701903,EBI-2547810
NRF1	Q16656-4	4	EBI-701903,EBI-11742836
PICALM	Q13492	8	EBI-701903,EBI-2803688
POU6F2	P78424	4	EBI-701903,EBI-12029004
RAI2	Q9Y5P3	5	EBI-701903,EBI-746228
REL	Q04864	3	EBI-701903,EBI-307352
RFX3	P48380	6	EBI-701903,EBI-742557
SAXO1	Q8IYX7	3	EBI-701903,EBI-3957636
SIGLEC6	O43699	3	EBI-701903,EBI-2814604
SIRT1	Q96EB6	2	EBI-701903,EBI-1802965
SP2	Q02086	3	EBI-701903,EBI-8651703
SPHK1	Q9NYA1	7	EBI-701903,EBI-985303
Trim54	Q9ERP3	2	EBI-701903,EBI-15626796	From Mus musculus.
ZFP64	Q9NPA5	3	EBI-701903,EBI-711679
ZFP64	Q9NTW7	3	EBI-701903,EBI-745730
ZMYM4	Q5VZL5	3	EBI-701903,EBI-2514659
ZNF131	P52739-2	5	EBI-701903,EBI-10213055
ZNF408	Q9H9D4	3	EBI-701903,EBI-347633
ZNF417	Q8TAU3	3	EBI-701903,EBI-740727

GO - Molecular functionⁱ

androgen receptor binding
Source: UniProtKB
Non-traceable author statementⁱ
- 15572661
identical protein binding
Source: IntAct
Inferred from physical interactionⁱ
- 10906324
- 18255255
transcription factor binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 15692560

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	108565, 154 interactors
CORUMⁱ	Q14192
Database of interacting proteins More...DIPⁱ	DIP-5980N
IntActⁱ	Q14192, 171 interactors
Molecular INTeraction database More...MINTⁱ	Q14192
STRINGⁱ	9606.ENSP00000322909

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Turnⁱ	8 – 10	Combined sources	3
Beta strandⁱ	20 – 22	Combined sources	3
Beta strandⁱ	25 – 27	Combined sources	3
Helixⁱ	29 – 36	Combined sources	8
Turnⁱ	41 – 43	Combined sources	3
Beta strandⁱ	45 – 47	Combined sources	3
Beta strandⁱ	53 – 56	Combined sources	4
Beta strandⁱ	59 – 62	Combined sources	4
Turnⁱ	63 – 65	Combined sources	3
Turnⁱ	69 – 71	Combined sources	3
Beta strandⁱ	76 – 78	Combined sources	3
Helixⁱ	90 – 97	Combined sources	8
Beta strandⁱ	101 – 104	Combined sources	4
Beta strandⁱ	110 – 112	Combined sources	3
Beta strandⁱ	114 – 117	Combined sources	4
Beta strandⁱ	120 – 123	Combined sources	4
Turnⁱ	124 – 127	Combined sources	4
Beta strandⁱ	130 – 132	Combined sources	3
Beta strandⁱ	138 – 144	Combined sources	7
Beta strandⁱ	147 – 150	Combined sources	4
Helixⁱ	151 – 157	Combined sources	7
Beta strandⁱ	163 – 165	Combined sources	3
Beta strandⁱ	171 – 182	Combined sources	12
Turnⁱ	183 – 185	Combined sources	3
Beta strandⁱ	189 – 191	Combined sources	3
Beta strandⁱ	201 – 208	Combined sources	8
Helixⁱ	210 – 216	Combined sources	7
Turnⁱ	222 – 225	Combined sources	4
Beta strandⁱ	231 – 233	Combined sources	3
Turnⁱ	246 – 248	Combined sources	3
Beta strandⁱ	252 – 254	Combined sources	3
Beta strandⁱ	267 – 271	Combined sources	5
Helixⁱ	273 – 277	Combined sources	5

Show more details

3D structure databases

ProteinModelPortalⁱ	Q14192
SMRⁱ	Q14192
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q14192

EvolutionaryTraceⁱ

Q14192

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	40 – 92	LIM zinc-binding 1PROSITE-ProRule annotationAdd BLAST	53
Domainⁱ	101 – 153	LIM zinc-binding 2PROSITE-ProRule annotationAdd BLAST	53
Domainⁱ	162 – 212	LIM zinc-binding 3PROSITE-ProRule annotationAdd BLAST	51
Domainⁱ	221 – 275	LIM zinc-binding 4PROSITE-ProRule annotationAdd BLAST	55

Domainⁱ

The third LIM zinc-binding mediates interaction with E4F1.

Zinc finger

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	7 – 31	C4-typeSequence analysisAdd BLAST		25

Keywords - Domainⁱ

LIM domain, Repeat, Zinc-finger

Phylogenomic databases

eggNOGⁱ	ENOG410KCU4 Eukaryota ENOG410XRFY LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118910
HOGENOMⁱ	HOG000231075
HOVERGENⁱ	HBG074526
InParanoidⁱ	Q14192
KEGG Orthology (KO) More...KOⁱ	K14380
PhylomeDBⁱ	Q14192
TreeFamⁱ	TF321684

Family and domain databases

InterProⁱ	View protein in InterPro IPR037987 FHL2/3/5 IPR001781 Znf_LIM
PANTHERⁱ	PTHR24205 PTHR24205, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00412 LIM, 4 hits
SMARTⁱ	View protein in SMART SM00132 LIM, 4 hits
PROSITEⁱ	View protein in PROSITE PS00478 LIM_DOMAIN_1, 4 hits PS50023 LIM_DOMAIN_2, 4 hits

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q14192-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTERFDCHHC NESLFGKKYI LREESPYCVV CFETLFANTC EECGKPIGCD 
        60         70         80         90        100
CKDLSYKDRH WHEACFHCSQ CRNSLVDKPF AAKEDQLLCT DCYSNEYSSK 
       110        120        130        140        150
CQECKKTIMP GTRKMEYKGS SWHETCFICH RCQQPIGTKS FIPKDNQNFC 
       160        170        180        190        200
VPCYEKQHAM QCVQCKKPIT TGGVTYREQP WHKECFVCTA CRKQLSGQRF 
       210        220        230        240        250
TARDDFAYCL NCFCDLYAKK CAGCTNPISG LGGTKYISFE ERQWHNDCFN 
       260        270 
CKKCSLSLVG RGFLTERDDI LCPDCGKDI

Length:279

Mass (Da):32,193

Last modified:October 17, 2006 - v3

Checksum:ⁱE94E3A7F6601F9F3

GO

Isoform 2 (identifier: Q14192-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
53-151: DLSYKDRHWH...IPKDNQNFCV → VPARWSTRAA...SQLAMTLPTA
152-279: Missing.

« Hide

        10         20         30         40         50
MTERFDCHHC NESLFGKKYI LREESPYCVV CFETLFANTC EECGKPIGCD 
        60         70         80         90        100
CKVPARWSTR AAAGMRPASS ATAASSQLEP RVSSPKTIRI SVCPAMRNNM 
       110        120        130        140        150
PCSAFSAKSP SPREGSLTGS SPGTRSASCA PPAGSSCLGS ASQLAMTLPT 

A

Show »

Length:151

Mass (Da):15,890

Checksum:ⁱ72F31D2DB830DB20

GO

Computationally mapped potential isoform sequencesⁱ

There are 6 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

J3KNW4	J3KNW4_HUMAN	Four and a half LIM domains protein... Four and a half LIM domains protein 2	FHL2	389	Annotation score:
A0A0A0MSG2	A0A0A0MSG2_HUMAN	Four and a half LIM domains protein... Four and a half LIM domains protein 2	FHL2	395	Annotation score:
U3KQT4	U3KQT4_HUMAN	Four and a half LIM domains protein... Four and a half LIM domains protein 2	FHL2	65	Annotation score:
F8WDA8	F8WDA8_HUMAN	Four and a half LIM domains protein... Four and a half LIM domains protein 2	FHL2	54	Annotation score:
C9J3S8	C9J3S8_HUMAN	Four and a half LIM domains protein... Four and a half LIM domains protein 2	FHL2	19	Annotation score:
E9PKF4	E9PKF4_HUMAN	Four and a half LIM domains protein... Four and a half LIM domains protein 2	FHL2	144	Annotation score:

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_067455	167	K → M3 Publications		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_056999	53 – 151	DLSYK…QNFCV → VPARWSTRAAAGMRPASSAT AASSQLEPRVSSPKTIRISV CPAMRNNMPCSAFSAKSPSP REGSLTGSSPGTRSASCAPP AGSSCLGSASQLAMTLPTA in isoform 2. 1 PublicationAdd BLAST		99
Alternative sequenceⁱVSP_057000	152 – 279	Missing in isoform 2. 1 PublicationAdd BLAST		128

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L42176 mRNA Translation: AAA85333.1 U29332 mRNA Translation: AAC52073.1 AB038794 Genomic DNA Translation: BAA92253.1 AB158503 mRNA Translation: BAD69710.1 DQ307067 mRNA Translation: ABC25549.1 AC012360 Genomic DNA No translation available. AC068273 Genomic DNA No translation available. AC108058 Genomic DNA No translation available. BC014397 mRNA Translation: AAH14397.1 U60117 mRNA Translation: AAC50794.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS2070.1 [Q14192-1]
PIRⁱ	JC6565
NCBI Reference Sequences More...RefSeqⁱ	NP_001034581.1, NM_001039492.2 [Q14192-1] NP_001305823.1, NM_001318894.1 [Q14192-1] NP_001305824.1, NM_001318895.1 [Q14192-1] NP_001305825.1, NM_001318896.1 [Q14192-1] NP_001305826.1, NM_001318897.1 NP_001441.4, NM_001450.3 [Q14192-1] NP_963849.1, NM_201555.1 [Q14192-1] NP_963851.2, NM_201557.3 [Q14192-1] XP_011509100.1, XM_011510798.2 [Q14192-1]
UniGeneⁱ	Hs.443687

Genome annotation databases

Ensemblⁱ	ENST00000322142; ENSP00000322909; ENSG00000115641 [Q14192-1] ENST00000358129; ENSP00000350846; ENSG00000115641 [Q14192-2] ENST00000393352; ENSP00000377020; ENSG00000115641 [Q14192-1] ENST00000393353; ENSP00000377021; ENSG00000115641 [Q14192-1] ENST00000408995; ENSP00000386633; ENSG00000115641 [Q14192-1] ENST00000409807; ENSP00000386665; ENSG00000115641 [Q14192-1]
GeneIDⁱ	2274
KEGGⁱ	hsa:2274
UCSC genome browser More...UCSCⁱ	uc061mpc.1 human [Q14192-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q14192	Four and a half LIM domains protein 2		HUMAN		395	UniRef100_Q14192
Uncharacterized protein		NOMLE		279
Uncharacterized protein FHL2 (Fragment)		HUMAN		110
FHL2 protein		HUMAN		279
Uncharacterized protein FHL2 (Fragment)		HUMAN		168
+3

Protein	Similar proteins		Species	Score	Length	Source
Q14192	Four and a half LIM domains protein 2		HUMAN		395	UniRef90_Q14192
Uncharacterized protein		NOMLE		279
Uncharacterized protein		GORGO		395
Uncharacterized protein		PAPAN		378
Uncharacterized protein		MACFA		377
+12
Q14192-2	FHL2 isoform 6		PANTR		151	UniRef90_Q14192-2
Four and a half LIM domains 2		SAIBB		151
Uncharacterized protein		MACMU		151
Uncharacterized protein		COLAP		151
Uncharacterized protein		CERAT		151
+12

Protein	Similar proteins		Species	Score	Length	Source
Q14192	Four and a half LIM domains protein 2		HUMAN		395	UniRef50_Q14192
Uncharacterized protein		NOMLE		279
Uncharacterized protein		GORGO		395
Uncharacterized protein		PAPAN		378
Uncharacterized protein		MACNE		377
+71
Q14192-2	Uncharacterized protein		RHIBE		151	UniRef50_Q14192-2
Four and a half LIM domains 2		SAIBB		151
FHL2 isoform 6		PANTR		151
Uncharacterized protein		MANLE		151
Uncharacterized protein		MACMU		151
+13

Cross-referencesⁱ

Web resourcesⁱ

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L42176 mRNA Translation: AAA85333.1 U29332 mRNA Translation: AAC52073.1 AB038794 Genomic DNA Translation: BAA92253.1 AB158503 mRNA Translation: BAD69710.1 DQ307067 mRNA Translation: ABC25549.1 AC012360 Genomic DNA No translation available. AC068273 Genomic DNA No translation available. AC108058 Genomic DNA No translation available. BC014397 mRNA Translation: AAH14397.1 U60117 mRNA Translation: AAC50794.1
CCDSⁱ	CCDS2070.1 [Q14192-1]
PIRⁱ	JC6565
RefSeqⁱ	NP_001034581.1, NM_001039492.2 [Q14192-1] NP_001305823.1, NM_001318894.1 [Q14192-1] NP_001305824.1, NM_001318895.1 [Q14192-1] NP_001305825.1, NM_001318896.1 [Q14192-1] NP_001305826.1, NM_001318897.1 NP_001441.4, NM_001450.3 [Q14192-1] NP_963849.1, NM_201555.1 [Q14192-1] NP_963851.2, NM_201557.3 [Q14192-1] XP_011509100.1, XM_011510798.2 [Q14192-1]
UniGeneⁱ	Hs.443687

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1X4K	NMR	-	A	101-159	[»]
	1X4L	NMR	-	A	221-279	[»]
	2D8Z	NMR	-	A	162-218	[»]
	2MIU	NMR	-	A	1-98	[»]
ProteinModelPortalⁱ	Q14192
SMRⁱ	Q14192
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	108565, 154 interactors
CORUMⁱ	Q14192
DIPⁱ	DIP-5980N
IntActⁱ	Q14192, 171 interactors
MINTⁱ	Q14192
STRINGⁱ	9606.ENSP00000322909

PTM databases

iPTMnetⁱ	Q14192
PhosphoSitePlusⁱ	Q14192
SwissPalmⁱ	Q14192

Polymorphism and mutation databases

BioMutaⁱ	FHL2
DMDMⁱ	116241364

2D gel databases

UCD-2DPAGEⁱ	Q14192

UCD-2DPAGEⁱ

Q14192

Proteomic databases

EPDⁱ	Q14192
PaxDbⁱ	Q14192
PeptideAtlasⁱ	Q14192
PRIDEⁱ	Q14192
ProteomicsDBⁱ	59914

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	2274
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000322142; ENSP00000322909; ENSG00000115641 [Q14192-1] ENST00000358129; ENSP00000350846; ENSG00000115641 [Q14192-2] ENST00000393352; ENSP00000377020; ENSG00000115641 [Q14192-1] ENST00000393353; ENSP00000377021; ENSG00000115641 [Q14192-1] ENST00000408995; ENSP00000386633; ENSG00000115641 [Q14192-1] ENST00000409807; ENSP00000386665; ENSG00000115641 [Q14192-1]
GeneIDⁱ	2274
KEGGⁱ	hsa:2274
UCSCⁱ	uc061mpc.1 human [Q14192-1]

Organism-specific databases

CTDⁱ	2274
DisGeNETⁱ	2274
EuPathDBⁱ	HostDB:ENSG00000115641.18
GeneCardsⁱ	FHL2
HGNCⁱ	HGNC:3703 FHL2
HPAⁱ	CAB008368 HPA005922 HPA006028
MalaCardsⁱ	FHL2
MIMⁱ	602633 gene
neXtProtⁱ	NX_Q14192
OpenTargetsⁱ	ENSG00000115641
Orphanetⁱ	154 Familial isolated dilated cardiomyopathy
PharmGKBⁱ	PA164
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410KCU4 Eukaryota ENOG410XRFY LUCA
GeneTreeⁱ	ENSGT00760000118910
HOGENOMⁱ	HOG000231075
HOVERGENⁱ	HBG074526
InParanoidⁱ	Q14192
KOⁱ	K14380
PhylomeDBⁱ	Q14192
TreeFamⁱ	TF321684

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1989781 PPARA activates gene expression
SIGNORⁱ	Q14192

Miscellaneous databases

ChiTaRSⁱ	FHL2 human
EvolutionaryTraceⁱ	Q14192
GeneWikiⁱ	FHL2
GenomeRNAiⁱ	2274
Protein Ontology More...PROⁱ	PR:Q14192
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000115641 Expressed in 215 organ(s), highest expression level in myocardium
CleanExⁱ	HS_FHL2
ExpressionAtlasⁱ	Q14192 baseline and differential
Genevisibleⁱ	Q14192 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR037987 FHL2/3/5 IPR001781 Znf_LIM
PANTHERⁱ	PTHR24205 PTHR24205, 1 hit
Pfamⁱ	View protein in Pfam PF00412 LIM, 4 hits
SMARTⁱ	View protein in SMART SM00132 LIM, 4 hits
PROSITEⁱ	View protein in PROSITE PS00478 LIM_DOMAIN_1, 4 hits PS50023 LIM_DOMAIN_2, 4 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	FHL2_HUMAN
Accessionⁱ	Q14192Primary (citable) accession number: Q14192 Secondary accession number(s): Q13229 , Q13644, Q2I5I4, Q5TM15, Q9P294
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
	Last sequence update:	October 17, 2006
	Last modified:	November 7, 2018
	This is version 183 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

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UniProtKB - Q14192 (FHL2_HUMAN)

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Four and a half LIM domains protein 2

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

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GO - Biological processi

Enzyme and pathway databases

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Organism-specific databases

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Nucleus

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Keywords - Cellular componenti

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Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

2D gel databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Zinc finger

Keywords - Domaini

Phylogenomic databases

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Natural variant

Alternative sequence

Sequence databases

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Keywords - Coding sequence diversityi

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Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

2D gel databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

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<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ