UniProtKB - Q14192 (FHL2_HUMAN)
Four and a half LIM domains protein 2
FHL2
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 7 – 31 | C4-typeSequence analysisAdd BLAST | 25 |
GO - Molecular functioni
- bHLH transcription factor binding Source: BHF-UCL
- identical protein binding Source: IntAct
- metal ion binding Source: UniProtKB-KW
- transcription coregulator activity Source: GO_Central
- transcription corepressor activity Source: BHF-UCL
- transcription factor binding Source: UniProtKB
GO - Biological processi
- atrial cardiac muscle cell development Source: Ensembl
- heart trabecula formation Source: Ensembl
- negative regulation of apoptotic process Source: UniProtKB
- negative regulation of calcineurin-NFAT signaling cascade Source: UniProtKB
- negative regulation of transcription by RNA polymerase II Source: UniProtKB
- osteoblast differentiation Source: Ensembl
- regulation of lipid metabolic process Source: Reactome
- response to hormone Source: BHF-UCL
- ventricular cardiac muscle cell development Source: Ensembl
Keywordsi
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q14192 |
Reactomei | R-HSA-1989781, PPARA activates gene expression |
SIGNORi | Q14192 |
Names & Taxonomyi
Protein namesi | Recommended name: Four and a half LIM domains protein 2Short name: FHL-2 Alternative name(s): LIM domain protein DRAL Skeletal muscle LIM-protein 3 Short name: SLIM-3 |
Gene namesi | Name:FHL2 Synonyms:DRAL, SLIM3 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:3703, FHL2 |
MIMi | 602633, gene |
neXtProti | NX_Q14192 |
VEuPathDBi | HostDB:ENSG00000115641.18 |
Subcellular locationi
Nucleus
- nucleoplasm Source: Reactome
- nucleus Source: GO_Central
Other locations
- focal adhesion Source: UniProtKB
- M band Source: Ensembl
- Z disc Source: GO_Central
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 2274 |
MalaCardsi | FHL2 |
OpenTargetsi | ENSG00000115641 |
Orphaneti | 154, Familial isolated dilated cardiomyopathy |
PharmGKBi | PA164 |
Miscellaneous databases
Pharosi | Q14192, Tbio |
Genetic variation databases
BioMutai | FHL2 |
DMDMi | 116241364 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000075737 | 1 – 279 | Four and a half LIM domains protein 2Add BLAST | 279 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 78 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 167 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 220 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 238 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q14192 |
jPOSTi | Q14192 |
MassIVEi | Q14192 |
PaxDbi | Q14192 |
PeptideAtlasi | Q14192 |
PRIDEi | Q14192 |
ProteomicsDBi | 59914 [Q14192-1] 65204 |
2D gel databases
UCD-2DPAGEi | Q14192 |
PTM databases
iPTMneti | Q14192 |
MetOSitei | Q14192 |
PhosphoSitePlusi | Q14192 |
SwissPalmi | Q14192 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000115641, Expressed in myocardium and 225 other tissues |
ExpressionAtlasi | Q14192, baseline and differential |
Genevisiblei | Q14192, HS |
Organism-specific databases
HPAi | ENSG00000115641, Group enriched (heart muscle, ovary) |
Interactioni
Subunit structurei
Interacts with ZNF638 and TTN/titin (PubMed:11813260, PubMed:12432079).
Interacts with E4F1 (PubMed:16652157).
Interacts with GRB7 (PubMed:18853468).
Interacts with SIRT1 and FOXO1 (PubMed:15692560).
Interacts with CEFIP (PubMed:28717008).
Interacts with calcineurin (By similarity).
Interacts with FOXK1 (By similarity).
By similarity6 PublicationsBinary interactionsi
Q14192
GO - Molecular functioni
- bHLH transcription factor binding Source: BHF-UCL
- identical protein binding Source: IntAct
- transcription factor binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 108565, 246 interactors |
CORUMi | Q14192 |
DIPi | DIP-5980N |
IntActi | Q14192, 208 interactors |
MINTi | Q14192 |
STRINGi | 9606.ENSP00000386665 |
Miscellaneous databases
RNActi | Q14192, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q14192 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q14192 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 40 – 92 | LIM zinc-binding 1PROSITE-ProRule annotationAdd BLAST | 53 | |
Domaini | 101 – 153 | LIM zinc-binding 2PROSITE-ProRule annotationAdd BLAST | 53 | |
Domaini | 162 – 212 | LIM zinc-binding 3PROSITE-ProRule annotationAdd BLAST | 51 | |
Domaini | 221 – 275 | LIM zinc-binding 4PROSITE-ProRule annotationAdd BLAST | 55 |
Domaini
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 7 – 31 | C4-typeSequence analysisAdd BLAST | 25 |
Keywords - Domaini
LIM domain, Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1704, Eukaryota |
GeneTreei | ENSGT00950000183028 |
HOGENOMi | CLU_001357_2_0_1 |
InParanoidi | Q14192 |
PhylomeDBi | Q14192 |
TreeFami | TF321684 |
Family and domain databases
IDEALi | IID00473 |
InterProi | View protein in InterPro IPR037987, FHL2/3/5 IPR001781, Znf_LIM |
PANTHERi | PTHR24205, PTHR24205, 1 hit |
Pfami | View protein in Pfam PF00412, LIM, 4 hits |
SMARTi | View protein in SMART SM00132, LIM, 4 hits |
PROSITEi | View protein in PROSITE PS00478, LIM_DOMAIN_1, 4 hits PS50023, LIM_DOMAIN_2, 4 hits |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MTERFDCHHC NESLFGKKYI LREESPYCVV CFETLFANTC EECGKPIGCD
60 70 80 90 100
CKDLSYKDRH WHEACFHCSQ CRNSLVDKPF AAKEDQLLCT DCYSNEYSSK
110 120 130 140 150
CQECKKTIMP GTRKMEYKGS SWHETCFICH RCQQPIGTKS FIPKDNQNFC
160 170 180 190 200
VPCYEKQHAM QCVQCKKPIT TGGVTYREQP WHKECFVCTA CRKQLSGQRF
210 220 230 240 250
TARDDFAYCL NCFCDLYAKK CAGCTNPISG LGGTKYISFE ERQWHNDCFN
260 270
CKKCSLSLVG RGFLTERDDI LCPDCGKDI
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF8WDA8 | F8WDA8_HUMAN | Four and a half LIM domains protein... | FHL2 | 54 | Annotation score: | ||
C9J3S8 | C9J3S8_HUMAN | Four and a half LIM domains protein... | FHL2 | 19 | Annotation score: | ||
U3KQT4 | U3KQT4_HUMAN | Four and a half LIM domains protein... | FHL2 | 65 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_067455 | 167 | K → M3 Publications | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_056999 | 53 – 151 | DLSYK…QNFCV → VPARWSTRAAAGMRPASSAT AASSQLEPRVSSPKTIRISV CPAMRNNMPCSAFSAKSPSP REGSLTGSSPGTRSASCAPP AGSSCLGSASQLAMTLPTA in isoform 2. 1 PublicationAdd BLAST | 99 | |
Alternative sequenceiVSP_057000 | 152 – 279 | Missing in isoform 2. 1 PublicationAdd BLAST | 128 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L42176 mRNA Translation: AAA85333.1 U29332 mRNA Translation: AAC52073.1 AB038794 Genomic DNA Translation: BAA92253.1 AB158503 mRNA Translation: BAD69710.1 DQ307067 mRNA Translation: ABC25549.1 AC012360 Genomic DNA No translation available. AC068273 Genomic DNA No translation available. AC108058 Genomic DNA No translation available. BC014397 mRNA Translation: AAH14397.1 U60117 mRNA Translation: AAC50794.1 |
CCDSi | CCDS2070.1 [Q14192-1] |
PIRi | JC6565 |
RefSeqi | NP_001034581.1, NM_001039492.2 [Q14192-1] NP_001305823.1, NM_001318894.1 [Q14192-1] NP_001305824.1, NM_001318895.1 [Q14192-1] NP_001305825.1, NM_001318896.1 [Q14192-1] NP_001305826.1, NM_001318897.1 NP_001441.4, NM_001450.3 [Q14192-1] NP_963849.1, NM_201555.1 [Q14192-1] NP_963851.2, NM_201557.3 [Q14192-1] XP_011509100.1, XM_011510798.2 |
Genome annotation databases
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L42176 mRNA Translation: AAA85333.1 U29332 mRNA Translation: AAC52073.1 AB038794 Genomic DNA Translation: BAA92253.1 AB158503 mRNA Translation: BAD69710.1 DQ307067 mRNA Translation: ABC25549.1 AC012360 Genomic DNA No translation available. AC068273 Genomic DNA No translation available. AC108058 Genomic DNA No translation available. BC014397 mRNA Translation: AAH14397.1 U60117 mRNA Translation: AAC50794.1 |
CCDSi | CCDS2070.1 [Q14192-1] |
PIRi | JC6565 |
RefSeqi | NP_001034581.1, NM_001039492.2 [Q14192-1] NP_001305823.1, NM_001318894.1 [Q14192-1] NP_001305824.1, NM_001318895.1 [Q14192-1] NP_001305825.1, NM_001318896.1 [Q14192-1] NP_001305826.1, NM_001318897.1 NP_001441.4, NM_001450.3 [Q14192-1] NP_963849.1, NM_201555.1 [Q14192-1] NP_963851.2, NM_201557.3 [Q14192-1] XP_011509100.1, XM_011510798.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1X4K | NMR | - | A | 101-159 | [»] | |
1X4L | NMR | - | A | 221-279 | [»] | |
2D8Z | NMR | - | A | 162-218 | [»] | |
2MIU | NMR | - | A | 1-98 | [»] | |
SMRi | Q14192 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 108565, 246 interactors |
CORUMi | Q14192 |
DIPi | DIP-5980N |
IntActi | Q14192, 208 interactors |
MINTi | Q14192 |
STRINGi | 9606.ENSP00000386665 |
PTM databases
iPTMneti | Q14192 |
MetOSitei | Q14192 |
PhosphoSitePlusi | Q14192 |
SwissPalmi | Q14192 |
Genetic variation databases
BioMutai | FHL2 |
DMDMi | 116241364 |
2D gel databases
UCD-2DPAGEi | Q14192 |
Proteomic databases
EPDi | Q14192 |
jPOSTi | Q14192 |
MassIVEi | Q14192 |
PaxDbi | Q14192 |
PeptideAtlasi | Q14192 |
PRIDEi | Q14192 |
ProteomicsDBi | 59914 [Q14192-1] 65204 |
Protocols and materials databases
Antibodypediai | 949, 335 antibodies |
DNASUi | 2274 |
Genome annotation databases
Organism-specific databases
CTDi | 2274 |
DisGeNETi | 2274 |
GeneCardsi | FHL2 |
HGNCi | HGNC:3703, FHL2 |
HPAi | ENSG00000115641, Group enriched (heart muscle, ovary) |
MalaCardsi | FHL2 |
MIMi | 602633, gene |
neXtProti | NX_Q14192 |
OpenTargetsi | ENSG00000115641 |
Orphaneti | 154, Familial isolated dilated cardiomyopathy |
PharmGKBi | PA164 |
VEuPathDBi | HostDB:ENSG00000115641.18 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1704, Eukaryota |
GeneTreei | ENSGT00950000183028 |
HOGENOMi | CLU_001357_2_0_1 |
InParanoidi | Q14192 |
PhylomeDBi | Q14192 |
TreeFami | TF321684 |
Enzyme and pathway databases
PathwayCommonsi | Q14192 |
Reactomei | R-HSA-1989781, PPARA activates gene expression |
SIGNORi | Q14192 |
Miscellaneous databases
BioGRID-ORCSi | 2274, 6 hits in 882 CRISPR screens |
ChiTaRSi | FHL2, human |
EvolutionaryTracei | Q14192 |
GeneWikii | FHL2 |
GenomeRNAii | 2274 |
Pharosi | Q14192, Tbio |
PROi | PR:Q14192 |
RNActi | Q14192, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000115641, Expressed in myocardium and 225 other tissues |
ExpressionAtlasi | Q14192, baseline and differential |
Genevisiblei | Q14192, HS |
Family and domain databases
IDEALi | IID00473 |
InterProi | View protein in InterPro IPR037987, FHL2/3/5 IPR001781, Znf_LIM |
PANTHERi | PTHR24205, PTHR24205, 1 hit |
Pfami | View protein in Pfam PF00412, LIM, 4 hits |
SMARTi | View protein in SMART SM00132, LIM, 4 hits |
PROSITEi | View protein in PROSITE PS00478, LIM_DOMAIN_1, 4 hits PS50023, LIM_DOMAIN_2, 4 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | FHL2_HUMAN | |
Accessioni | Q14192Primary (citable) accession number: Q14192 Secondary accession number(s): Q13229 Q9P294 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | October 17, 2006 | |
Last modified: | February 10, 2021 | |
This is version 201 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references