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UniProtKB - Q14185 (DOCK1_HUMAN)

Entry version 185 (10 Feb 2021)
Sequence version 2 (14 Oct 2008)
Previous versions | rss
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Protein

Dedicator of cytokinesis protein 1

Gene

DOCK1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Along with DOCK1, mediates CRK/CRKL regulation of epithelial and endothelial cell spreading and migration on type IV collagen (PubMed:19004829). Functions as a guanine nucleotide exchange factor (GEF), which activates Rac Rho small GTPases by exchanging bound GDP for free GTP. Its GEF activity may be enhanced by ELMO1 (PubMed:8657152).2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGuanine-nucleotide releasing factor
Biological processApoptosis, Phagocytosis

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q14185

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-2029482, Regulation of actin dynamics for phagocytic cup formation
R-HSA-418885, DCC mediated attractive signaling
R-HSA-4420097, VEGFA-VEGFR2 Pathway
R-HSA-8849471, PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
R-HSA-9664422, FCGR3A-mediated phagocytosis
R-HSA-983231, Factors involved in megakaryocyte development and platelet production

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Dedicator of cytokinesis protein 1
Alternative name(s):
180 kDa protein downstream of CRK
Short name:
DOCK180
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DOCK1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:2987, DOCK1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		601403, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q14185

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000150760.12

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi1401 – 1402YI → AA: Abolishes Rac GEF activity. 1 Publication2
Mutagenesisi1487 – 1489ISP → AAA: Abolishes Rac GEF activity. 1 Publication3

Organism-specific databases

DisGeNET

More...DisGeNETi		1793

Open Targets

More...OpenTargetsi		ENSG00000150760

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA27453

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q14185, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		DOCK1

Domain mapping of disease mutations (DMDM)

More...DMDMi		209572608

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001899841 – 1865Dedicator of cytokinesis protein 1Add BLAST1865

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1681PhosphoserineCombined sources1
Modified residuei1743PhosphoserineBy similarity1
Modified residuei1751PhosphoserineCombined sources1
Modified residuei1756PhosphoserineBy similarity1
Modified residuei1761PhosphoserineBy similarity1
Modified residuei1764PhosphoserineBy similarity1
Modified residuei1767PhosphothreonineBy similarity1
Modified residuei1772PhosphothreonineBy similarity1
Modified residuei1858PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q14185

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q14185

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q14185

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q14185

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q14185

PeptideAtlas

More...PeptideAtlasi		Q14185

PRoteomics IDEntifications database

More...PRIDEi		Q14185

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		59903

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q14185

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q14185

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in placenta, lung, kidney, pancreas and ovary. Expressed at intermediate level in thymus, testes and colon.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000150760, Expressed in lung and 239 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q14185, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q14185, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000150760, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with the SH3 domains of CRK and NCK2 via multiple sites (PubMed:8657152, PubMed:8662907, PubMed:11240126).

Interacts with nucleotide-free RAC1 via its DOCKER domain (PubMed:9808620, PubMed:12134158).

Interacts with ELMO1, ELMO2 and probably ELMO3 via its SH3 domain (PubMed:12134158).

Interacts with ADGRB1.

Identified in a complex with AUTS2 and ELMO2 (By similarity).

By similarity6 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		108128, 29 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q14185

Database of interacting proteins

More...DIPi		DIP-29391N

Protein interaction database and analysis system

More...IntActi		Q14185, 25 interactors

Molecular INTeraction database

More...MINTi		Q14185

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000280333

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q14185, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11865
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Biological Magnetic Resonance Data Bank

More...BMRBi		Q14185

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q14185

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q14185

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini9 – 70SH3PROSITE-ProRule annotationAdd BLAST62
Domaini425 – 609C2 DOCK-typePROSITE-ProRule annotationAdd BLAST185
Domaini1207 – 1617DOCKERPROSITE-ProRule annotationAdd BLAST411

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1687 – 1695Phosphoinositide-bindingSequence analysis9
Regioni1793 – 1819Interaction with NCK2 second and third SH3 domain (minor)Add BLAST27
Regioni1820 – 1836Interaction with NCK2 third SH3 domain (major)Add BLAST17
Regioni1837 – 1852Interaction with NCK2 (minor)Add BLAST16

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi1799 – 1805SH3-binding; interaction with CRKSequence analysis7
Motifi1838 – 1843SH3-binding; interaction with CRKSequence analysis6

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The DOCKER domain is necessary and sufficient for the GEF activity.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the DOCK family.PROSITE-ProRule annotation

Keywords - Domaini

SH3 domain, SH3-binding

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1998, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000154974

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_000595_2_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q14185

Database of Orthologous Groups

More...OrthoDBi		102580at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q14185

TreeFam database of animal gene trees

More...TreeFami		TF300423

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.20.1270.350, 1 hit
1.20.58.740, 1 hit
1.25.40.410, 1 hit
2.60.40.150, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR016024, ARM-type_fold
IPR035892, C2_domain_sf
IPR027007, DHR-1_domain
IPR027357, DHR-2
IPR026791, DOCK
IPR010703, DOCK_C
IPR043161, DOCK_C_lobe_A
IPR043162, DOCK_C_lobe_C
IPR032376, DOCK_N
IPR042455, DOCK_N_sub1
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain

The PANTHER Classification System

More...PANTHERi		PTHR45653, PTHR45653, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF06920, DHR-2, 1 hit
PF14429, DOCK-C2, 1 hit
PF16172, DOCK_N, 1 hit
PF00018, SH3_1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00326, SH3, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48371, SSF48371, 1 hit
SSF50044, SSF50044, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51650, C2_DOCK, 1 hit
PS51651, DOCKER, 1 hit
PS50002, SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q14185-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTRWVPTKRE EKYGVAFYNY DARGADELSL QIGDTVHILE TYEGWYRGYT 
        60         70         80         90        100
LRKKSKKGIF PASYIHLKEA IVEGKGQHET VIPGDLPLIQ EVTTTLREWS 
       110        120        130        140        150
TIWRQLYVQD NREMFRSVRH MIYDLIEWRS QILSGTLPQD ELKELKKKVT 
       160        170        180        190        200
AKIDYGNRIL DLDLVVRDED GNILDPELTS TISLFRAHEI ASKQVEERLQ 
       210        220        230        240        250
EEKSQKQNID INRQAKFAAT PSLALFVNLK NVVCKIGEDA EVLMSLYDPV 
       260        270        280        290        300
ESKFISENYL VRWSSSGLPK DIDRLHNLRA VFTDLGSKDL KREKISFVCQ 
       310        320        330        340        350
IVRVGRMELR DNNTRKLTSG LRRPFGVAVM DVTDIINGKV DDEDKQHFIP 
       360        370        380        390        400
FQPVAGENDF LQTVINKVIA AKEVNHKGQG LWVTLKLLPG DIHQIRKEFP 
       410        420        430        440        450
HLVDRTTAVA RKTGFPEIIM PGDVRNDIYV TLVQGDFDKG SKTTAKNVEV 
       460        470        480        490        500
TVSVYDEDGK RLEHVIFPGA GDEAISEYKS VIYYQVKQPR WFETVKVAIP 
       510        520        530        540        550
IEDVNRSHLR FTFRHRSSQD SKDKSEKIFA LAFVKLMRYD GTTLRDGEHD 
       560        570        580        590        600
LIVYKAEAKK LEDAATYLSL PSTKAELEEK GHSATGKSMQ SLGSCTISKD 
       610        620        630        640        650
SFQISTLVCS TKLTQNVDLL GLLKWRSNTS LLQQNLRQLM KVDGGEVVKF 
       660        670        680        690        700
LQDTLDALFN IMMENSESET FDTLVFDALV FIIGLIADRK FQHFNPVLET 
       710        720        730        740        750
YIKKHFSATL AYTKLTKVLK NYVDGAEKPG VNEQLYKAMK ALESIFKFIV 
       760        770        780        790        800
RSRILFNQLY ENKGEADFVE SLLQLFRSIN DMMSSMSDQT VRVKGAALKY 
       810        820        830        840        850
LPTIVNDVKL VFDPKELSKM FTEFILNVPM GLLTIQKLYC LIEIVHSDLF 
       860        870        880        890        900
TQHDCREILL PMMTDQLKYH LERQEDLEAC CQLLSHILEV LYRKDVGPTQ 
       910        920        930        940        950
RHVQIIMEKL LRTVNRTVIS MGRDSELIGN FVACMTAILR QMEDYHYAHL 
       960        970        980        990       1000
IKTFGKMRTD VVDFLMETFI MFKNLIGKNV YPFDWVIMNM VQNKVFLRAI 
      1010       1020       1030       1040       1050
NQYADMLNKK FLDQANFELQ LWNNYFHLAV AFLTQESLQL ENFSSAKRAK 
      1060       1070       1080       1090       1100
ILNKYGDMRR QIGFEIRDMW YNLGQHKIKF IPEMVGPILE MTLIPETELR 
      1110       1120       1130       1140       1150
KATIPIFFDM MQCEFHSTRS FQMFENEIIT KLDHEVEGGR GDEQYKVLFD 
      1160       1170       1180       1190       1200
KILLEHCRKH KYLAKTGETF VKLVVRLMER LLDYRTIMHD ENKENRMSCT 
      1210       1220       1230       1240       1250
VNVLNFYKEI EREEMYIRYL YKLCDLHKEC DNYTEAAYTL LLHAKLLKWS 
      1260       1270       1280       1290       1300
EDVCVAHLTQ RDGYQATTQG QLKEQLYQEI IHYFDKGKMW EEAIALGKEL 
      1310       1320       1330       1340       1350
AEQYENEMFD YEQLSELLKK QAQFYENIVK VIRPKPDYFA VGYYGQGFPT 
      1360       1370       1380       1390       1400
FLRGKVFIYR GKEYERREDF EARLLTQFPN AEKMKTTSPP GDDIKNSPGQ 
      1410       1420       1430       1440       1450
YIQCFTVKPK LDLPPKFHRP VSEQIVSFYR VNEVQRFEYS RPIRKGEKNP 
      1460       1470       1480       1490       1500
DNEFANMWIE RTIYTTAYKL PGILRWFEVK SVFMVEISPL ENAIETMQLT 
      1510       1520       1530       1540       1550
NDKINSMVQQ HLDDPSLPIN PLSMLLNGIV DPAVMGGFAN YEKAFFTDRY 
      1560       1570       1580       1590       1600
LQEHPEAHEK IEKLKDLIAW QIPFLAEGIR IHGDKVTEAL RPFHERMEAC 
      1610       1620       1630       1640       1650
FKQLKEKVEK EYGVRIMPSS LDDRRGSRPR SMVRSFTMPS SSRPLSVASV 
      1660       1670       1680       1690       1700
SSLSSDSTPS RPGSDGFALE PLLPKKMHSR SQDKLDKDDL EKEKKDKKKE 
      1710       1720       1730       1740       1750
KRNSKHQEIF EKEFKPTDIS LQQSEAVILS ETISPLRPQR PKSQVMNVIG 
      1760       1770       1780       1790       1800
SERRFSVSPS SPSSQQTPPP VTPRAKLSFS MQSSLELNGM TGADVADVPP 
      1810       1820       1830       1840       1850
PLPLKGSVAD YGNLMENQDL LGSPTPPPPP PHQRHLPPPL PSKTPPPPPP 
      1860 
KTTRKQASVD SGIVQ
Length:1,865
Mass (Da):215,346
Last modified:October 14, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i940C5AFD047EBEDE
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A096LNH6A0A096LNH6_HUMAN
Dedicator of cytokinesis protein 1
DOCK1
1,886Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1857A → T in BAA09454 (PubMed:8657152).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0599711793A → T. Corresponds to variant dbSNP:rs869801Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
D50857 mRNA Translation: BAA09454.1
AL157711 Genomic DNA No translation available.
AL359094 Genomic DNA No translation available.
BX470201 Genomic DNA No translation available.
AL390920 Genomic DNA No translation available.
AL607029 Genomic DNA No translation available.
AL355316 Genomic DNA No translation available.
BX470155 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS73222.1

NCBI Reference Sequences

More...RefSeqi		NP_001371.1, NM_001380.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000280333; ENSP00000280333; ENSG00000150760

Database of genes from NCBI RefSeq genomes

More...GeneIDi		1793

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:1793

UCSC genome browser

More...UCSCi		uc001ljt.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50857 mRNA Translation: BAA09454.1
AL157711 Genomic DNA No translation available.
AL359094 Genomic DNA No translation available.
BX470201 Genomic DNA No translation available.
AL390920 Genomic DNA No translation available.
AL607029 Genomic DNA No translation available.
AL355316 Genomic DNA No translation available.
BX470155 Genomic DNA No translation available.
CCDSiCCDS73222.1
RefSeqiNP_001371.1, NM_001380.4

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3L4CX-ray2.37A/B422-619[»]
BMRBiQ14185
SMRiQ14185
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi108128, 29 interactors
CORUMiQ14185
DIPiDIP-29391N
IntActiQ14185, 25 interactors
MINTiQ14185
STRINGi9606.ENSP00000280333

PTM databases

iPTMnetiQ14185
PhosphoSitePlusiQ14185

Genetic variation databases

BioMutaiDOCK1
DMDMi209572608

Proteomic databases

EPDiQ14185
jPOSTiQ14185
MassIVEiQ14185
MaxQBiQ14185
PaxDbiQ14185
PeptideAtlasiQ14185
PRIDEiQ14185
ProteomicsDBi59903

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		3822, 257 antibodies

Genome annotation databases

EnsembliENST00000280333; ENSP00000280333; ENSG00000150760
GeneIDi1793
KEGGihsa:1793
UCSCiuc001ljt.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		1793
DisGeNETi1793

GeneCards: human genes, protein and diseases

More...GeneCardsi		DOCK1
HGNCiHGNC:2987, DOCK1
HPAiENSG00000150760, Low tissue specificity
MIMi601403, gene
neXtProtiNX_Q14185
OpenTargetsiENSG00000150760
PharmGKBiPA27453
VEuPathDBiHostDB:ENSG00000150760.12

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1998, Eukaryota
GeneTreeiENSGT00940000154974
HOGENOMiCLU_000595_2_1_1
InParanoidiQ14185
OrthoDBi102580at2759
PhylomeDBiQ14185
TreeFamiTF300423

Enzyme and pathway databases

PathwayCommonsiQ14185
ReactomeiR-HSA-2029482, Regulation of actin dynamics for phagocytic cup formation
R-HSA-418885, DCC mediated attractive signaling
R-HSA-4420097, VEGFA-VEGFR2 Pathway
R-HSA-8849471, PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
R-HSA-9664422, FCGR3A-mediated phagocytosis
R-HSA-983231, Factors involved in megakaryocyte development and platelet production

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		1793, 6 hits in 143 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		DOCK1, human
EvolutionaryTraceiQ14185

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Dock180

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		1793
PharosiQ14185, Tbio

Protein Ontology

More...PROi		PR:Q14185
RNActiQ14185, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000150760, Expressed in lung and 239 other tissues
ExpressionAtlasiQ14185, baseline and differential
GenevisibleiQ14185, HS

Family and domain databases

Gene3Di1.20.1270.350, 1 hit
1.20.58.740, 1 hit
1.25.40.410, 1 hit
2.60.40.150, 1 hit
InterProiView protein in InterPro
IPR016024, ARM-type_fold
IPR035892, C2_domain_sf
IPR027007, DHR-1_domain
IPR027357, DHR-2
IPR026791, DOCK
IPR010703, DOCK_C
IPR043161, DOCK_C_lobe_A
IPR043162, DOCK_C_lobe_C
IPR032376, DOCK_N
IPR042455, DOCK_N_sub1
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain
PANTHERiPTHR45653, PTHR45653, 1 hit
PfamiView protein in Pfam
PF06920, DHR-2, 1 hit
PF14429, DOCK-C2, 1 hit
PF16172, DOCK_N, 1 hit
PF00018, SH3_1, 1 hit
SMARTiView protein in SMART
SM00326, SH3, 1 hit
SUPFAMiSSF48371, SSF48371, 1 hit
SSF50044, SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS51650, C2_DOCK, 1 hit
PS51651, DOCKER, 1 hit
PS50002, SH3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDOCK1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q14185
Secondary accession number(s): A9Z1Z5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 3, 2003
Last sequence update: October 14, 2008
Last modified: February 10, 2021
This is version 185 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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