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Entry version 157 (16 Oct 2019)
Sequence version 2 (02 May 2002)
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Protein

Tubulin--tyrosine ligase-like protein 12

Gene

TTLL12

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Negatively regulates post-translational modifications of tubulin, including detyrosination of the C-terminus and polyglutamylation of glutamate residues (PubMed:20162578, PubMed:23251473). Also, indirectly promotes histone H4 trimethylation at 'Lys-20' (H4K20me3) (PubMed:23251473). Probably by controlling tubulin and/or histone H4 post-translational modifications, plays a role in mitosis and in maintaining chromosome number stability (PubMed:20162578, PubMed:23251473). During RNA virus-mediated infection, acts as a negative regulator of the DDX58/RIG-I pathway by preventing MAVS binding to TBK1 and IKBKE (PubMed:28011935).3 Publications

Caution

Although it belongs to the tubulin--tyrosine ligase family, the TTL domain lacks some of the ATP binding sites predicted to be essential for TTL activity (PubMed:23251473). Lacks tyrosine ligase activity in vitro (PubMed:23251473). Lacks glutamylation activity in vitro (By similarity). Although TTLL12 contains a potential SET-like domain in the N-terminus, it does not have lysine methyltransferase activity towards histone in vitro (PubMed:23251473).By similarity1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei468ATPBy similarity1
Binding sitei470ATPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi450 – 453ATP bindingBy similarity4

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processImmunity, Innate immunity
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-8955332 Carboxyterminal post-translational modifications of tubulin

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tubulin--tyrosine ligase-like protein 12
Alternative name(s):
Inactive tubulin--tyrosine ligase-like protein 12Curated
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TTLL12
Synonyms:KIAA0153
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 22

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:28974 TTLL12

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q14166

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi244Y → A: Decreases expression of IFNB1 mRNA following infection with Sendai virus. 1 Publication1
Mutagenesisi605E → A: Decreases expression of IFNB1 mRNA following infection with Sendai virus. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
23170

Open Targets

More...
OpenTargetsi
ENSG00000100304

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA143485663

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q14166

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TTLL12

Domain mapping of disease mutations (DMDM)

More...
DMDMi
20455527

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002124461 – 644Tubulin--tyrosine ligase-like protein 12Add BLAST644

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q14166

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q14166

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q14166

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q14166

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q14166

PeptideAtlas

More...
PeptideAtlasi
Q14166

PRoteomics IDEntifications database

More...
PRIDEi
Q14166

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
59894

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q14166

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q14166

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q14166

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the basal layer of prostate and endothelial cells. Increased expression in prostatic intraepithelial neoplasia and metastatic lesions.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000100304 Expressed in 205 organ(s), highest expression level in vagina

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q14166 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q14166 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB046029
HPA003054

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with MAVS; the interaction prevents MAVS binding to TBK1 and IKBKE (PubMed:28011935).

Interacts (via N-terminus) with TBK1 (via protein kinase domain) (PubMed:28011935).

Interacts (via TTL domain) with IKBKE (via protein kinase domain) (PubMed:28011935).

Interacts with tubulin alpha (PubMed:23251473).

Interacts with histone H3 and histone H4 (when trimethylated at 'Lys-20' (H4K20me3)) (PubMed:23251473).

Interacts with CBX3 (PubMed:23251473).

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
116782, 65 interactors

Protein interaction database and analysis system

More...
IntActi
Q14166, 22 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000216129

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini300 – 644TTLPROSITE-ProRule annotationAdd BLAST345

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the tubulin--tyrosine ligase family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2155 Eukaryota
ENOG410XQ0A LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000006760

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000006517

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q14166

KEGG Orthology (KO)

More...
KOi
K16609

Identification of Orthologs from Complete Genome Data

More...
OMAi
YAADIML

Database of Orthologous Groups

More...
OrthoDBi
611643at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q14166

TreeFam database of animal gene trees

More...
TreeFami
TF313037

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.1490.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013815 ATP_grasp_subdomain_1
IPR004344 TTL/TTLL_fam
IPR027749 TTLL12

The PANTHER Classification System

More...
PANTHERi
PTHR46088 PTHR46088, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03133 TTL, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51221 TTL, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q14166-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEAERGPERR PAERSSPGQT PEEGAQALAE FAALHGPALR ASGVPERYWG
60 70 80 90 100
RLLHKLEHEV FDAGEVFGIM QVEEVEEEED EAAREVRKQQ PNPGNELCYK
110 120 130 140 150
VIVTRESGLQ AAHPNSIFLI DHAWTCRVEH ARQQLQQVPG LLHRMANLMG
160 170 180 190 200
IEFHGELPST EAVALVLEEM WKFNQTYQLA HGTAEEKMPV WYIMDEFGSR
210 220 230 240 250
IQHADVPSFA TAPFFYMPQQ VAYTLLWPLR DLDTGEEVTR DFAYGETDPL
260 270 280 290 300
IRKCMLLPWA PTDMLDLSSC TPEPPAEHYQ AILEENKEKL PLDINPVVHP
310 320 330 340 350
HGHIFKVYTD VQQVASSLTH PRFTLTQSEA DADILFNFSH FKDYRKLSQE
360 370 380 390 400
RPGVLLNQFP CENLLTVKDC LASIARRAGG PEGPPWLPRT FNLRTELPQF
410 420 430 440 450
VSYFQQRERW GEDNHWICKP WNLARSLDTH VTKSLHSIIR HRESTPKVVS
460 470 480 490 500
KYIESPVLFL REDVGKVKFD IRYIVLLRSV RPLRLFVYDV FWLRFSNRAF
510 520 530 540 550
ALNDLDDYEK HFTVMNYDPD VVLKQVHCEE FIPEFEKQYP EFPWTDVQAE
560 570 580 590 600
IFRAFTELFQ VACAKPPPLG LCDYPSSRAM YAVDLMLKWD NGPDGRRVMQ
610 620 630 640
PQILEVNFNP DCERACRYHP TFFNDVFSTL FLDQPGGCHV TCLV
Length:644
Mass (Da):74,404
Last modified:May 2, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBFF552774DF500EF
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
V9GY16V9GY16_HUMAN
Tubulin--tyrosine ligase-like prote...
TTLL12
65Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05241384R → W. Corresponds to variant dbSNP:rs138951Ensembl.1
Natural variantiVAR_05241495N → S. Corresponds to variant dbSNP:rs13058467Ensembl.1
Natural variantiVAR_052415297V → M. Corresponds to variant dbSNP:rs11704935Ensembl.1
Natural variantiVAR_052416464V → M. Corresponds to variant dbSNP:rs34074034Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CT841516 mRNA Translation: CAJ86446.1
Z82214 Genomic DNA No translation available.
CH471138 Genomic DNA Translation: EAW73291.1
BC001070 mRNA Translation: AAH01070.1
D63487 mRNA Translation: BAA09774.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS14047.1

NCBI Reference Sequences

More...
RefSeqi
NP_055955.1, NM_015140.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000216129; ENSP00000216129; ENSG00000100304

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
23170

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:23170

UCSC genome browser

More...
UCSCi
uc003bdq.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT841516 mRNA Translation: CAJ86446.1
Z82214 Genomic DNA No translation available.
CH471138 Genomic DNA Translation: EAW73291.1
BC001070 mRNA Translation: AAH01070.1
D63487 mRNA Translation: BAA09774.1
CCDSiCCDS14047.1
RefSeqiNP_055955.1, NM_015140.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi116782, 65 interactors
IntActiQ14166, 22 interactors
STRINGi9606.ENSP00000216129

PTM databases

iPTMnetiQ14166
PhosphoSitePlusiQ14166
SwissPalmiQ14166

Polymorphism and mutation databases

BioMutaiTTLL12
DMDMi20455527

Proteomic databases

EPDiQ14166
jPOSTiQ14166
MassIVEiQ14166
MaxQBiQ14166
PaxDbiQ14166
PeptideAtlasiQ14166
PRIDEiQ14166
ProteomicsDBi59894

Genome annotation databases

EnsembliENST00000216129; ENSP00000216129; ENSG00000100304
GeneIDi23170
KEGGihsa:23170
UCSCiuc003bdq.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23170
DisGeNETi23170

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TTLL12
HGNCiHGNC:28974 TTLL12
HPAiCAB046029
HPA003054
neXtProtiNX_Q14166
OpenTargetsiENSG00000100304
PharmGKBiPA143485663

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2155 Eukaryota
ENOG410XQ0A LUCA
GeneTreeiENSGT00390000006760
HOGENOMiHOG000006517
InParanoidiQ14166
KOiK16609
OMAiYAADIML
OrthoDBi611643at2759
PhylomeDBiQ14166
TreeFamiTF313037

Enzyme and pathway databases

ReactomeiR-HSA-8955332 Carboxyterminal post-translational modifications of tubulin

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
TTLL12 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
23170
PharosiQ14166

Protein Ontology

More...
PROi
PR:Q14166

Gene expression databases

BgeeiENSG00000100304 Expressed in 205 organ(s), highest expression level in vagina
ExpressionAtlasiQ14166 baseline and differential
GenevisibleiQ14166 HS

Family and domain databases

Gene3Di3.30.1490.20, 1 hit
InterProiView protein in InterPro
IPR013815 ATP_grasp_subdomain_1
IPR004344 TTL/TTLL_fam
IPR027749 TTLL12
PANTHERiPTHR46088 PTHR46088, 1 hit
PfamiView protein in Pfam
PF03133 TTL, 1 hit
PROSITEiView protein in PROSITE
PS51221 TTL, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTTL12_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q14166
Secondary accession number(s): Q20WK5, Q9UGU3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 2, 2002
Last modified: October 16, 2019
This is version 157 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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