Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 168 (10 Apr 2019)
Sequence version 3 (02 Nov 2010)
Previous versions | rss
Other tutorials and videosHelp videoFeedback
Protein

Scavenger receptor class F member 1

Gene

SCARF1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Mediates the binding and degradation of acetylated low density lipoprotein (Ac-LDL). Mediates heterophilic interactions, suggesting a function as adhesion protein. Plays a role in the regulation of neurite-like outgrowth (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor
Biological processCell adhesion

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-3000484 Scavenging by Class F Receptors

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Scavenger receptor class F member 1
Alternative name(s):
Acetyl LDL receptor
Scavenger receptor expressed by endothelial cells 1
Short name:
SREC-I
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SCARF1
Synonyms:KIAA0149, SREC
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000074660.15

Human Gene Nomenclature Database

More...
HGNCi
HGNC:16820 SCARF1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
607873 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q14162

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini20 – 421ExtracellularSequence analysisAdd BLAST402
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei422 – 442HelicalSequence analysisAdd BLAST21
Topological domaini443 – 830CytoplasmicSequence analysisAdd BLAST388

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000074660

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA38420

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SCARF1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
311033530

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 19Sequence analysisAdd BLAST19
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000773820 – 830Scavenger receptor class F member 1Add BLAST811

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi57 ↔ 69PROSITE-ProRule annotation
Disulfide bondi63 ↔ 75PROSITE-ProRule annotation
Disulfide bondi77 ↔ 86PROSITE-ProRule annotation
Disulfide bondi99 ↔ 111PROSITE-ProRule annotation
Disulfide bondi105 ↔ 118PROSITE-ProRule annotation
Disulfide bondi120 ↔ 129PROSITE-ProRule annotation
Disulfide bondi159 ↔ 172PROSITE-ProRule annotation
Disulfide bondi165 ↔ 179PROSITE-ProRule annotation
Disulfide bondi181 ↔ 190PROSITE-ProRule annotation
Disulfide bondi219 ↔ 230PROSITE-ProRule annotation
Disulfide bondi225 ↔ 237PROSITE-ProRule annotation
Disulfide bondi239 ↔ 248PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi289N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi306 ↔ 319PROSITE-ProRule annotation
Disulfide bondi313 ↔ 326PROSITE-ProRule annotation
Disulfide bondi329 ↔ 338PROSITE-ProRule annotation
Disulfide bondi355 ↔ 363PROSITE-ProRule annotation
Disulfide bondi358 ↔ 370PROSITE-ProRule annotation
Disulfide bondi372 ↔ 381PROSITE-ProRule annotation
Glycosylationi382N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi393N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei589PhosphoserineBy similarity1
Modified residuei606PhosphoserineCombined sources1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q14162

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q14162

PeptideAtlas

More...
PeptideAtlasi
Q14162

PRoteomics IDEntifications database

More...
PRIDEi
Q14162

ProteomicsDB human proteome resource

More...
ProteomicsDBi
59887
59888 [Q14162-2]
59889 [Q14162-3]
59890 [Q14162-4]
59891 [Q14162-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q14162

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q14162

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q14162

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Endothelial cells.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000074660 Expressed in 159 organ(s), highest expression level in spleen

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q14162 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q14162 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA072936

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterophilic interaction with SREC2 via its extracellular domain. The heterophilic interaction is suppressed by the presence of ligand such as Ac-LDL. Interacts with AVIL (By similarity).By similarity

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q14162, 17 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000263071

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q14162

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q14162

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini53 – 87EGF-like 1PROSITE-ProRule annotationAdd BLAST35
Domaini95 – 130EGF-like 2PROSITE-ProRule annotationAdd BLAST36
Domaini155 – 191EGF-like 3PROSITE-ProRule annotationAdd BLAST37
Domaini215 – 249EGF-like 4PROSITE-ProRule annotationAdd BLAST35
Domaini302 – 339EGF-like 5PROSITE-ProRule annotationAdd BLAST38
Domaini351 – 382EGF-like 6PROSITE-ProRule annotationAdd BLAST32

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi431 – 438Poly-Leu8
Compositional biasi476 – 620Pro/Ser-richAdd BLAST145
Compositional biasi622 – 798Gly-richAdd BLAST177

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1218 Eukaryota
ENOG410XQWV LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000183101

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000015093

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG099941

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q14162

Identification of Orthologs from Complete Genome Data

More...
OMAi
CVPPQEG

Database of Orthologous Groups

More...
OrthoDBi
110992at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q14162

TreeFam database of animal gene trees

More...
TreeFami
TF332598

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR009030 Growth_fac_rcpt_cys_sf
IPR002049 Laminin_EGF
IPR033329 SCARF1

The PANTHER Classification System

More...
PANTHERi
PTHR24043:SF0 PTHR24043:SF0, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00053 Laminin_EGF, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00181 EGF, 9 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57184 SSF57184, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00022 EGF_1, 6 hits
PS01186 EGF_2, 6 hits
PS50026 EGF_3, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q14162-1) [UniParc]FASTAAdd to basket
Also known as: SREC-1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGLGLLLPLL LLWTRGTQGS ELDPKGQHVC VASSPSAELQ CCAGWRQKDQ
60 70 80 90 100
ECTIPICEGP DACQKDEVCV KPGLCRCKPG FFGAHCSSRC PGQYWGPDCR
110 120 130 140 150
ESCPCHPHGQ CEPATGACQC QADRWGARCE FPCACGPHGR CDPATGVCHC
160 170 180 190 200
EPGWWSSTCR RPCQCNTAAA RCEQATGACV CKPGWWGRRC SFRCNCHGSP
210 220 230 240 250
CEQDSGRCAC RPGWWGPECQ QQCECVRGRC SAASGECTCP PGFRGARCEL
260 270 280 290 300
PCPAGSHGVQ CAHSCGRCKH NEPCSPDTGS CESCEPGWNG TQCQQPCLPG
310 320 330 340 350
TFGESCEQQC PHCRHGEACE PDTGHCQRCD PGWLGPRCED PCPTGTFGED
360 370 380 390 400
CGSTCPTCVQ GSCDTVTGDC VCSAGYWGPS CNASCPAGFH GNNCSVPCEC
410 420 430 440 450
PEGLCHPVSG SCQPGSGSRD TALIAGSLVP LLLLFLGLAC CACCCWAPRS
460 470 480 490 500
DLKDRPARDG ATVSRMKLQV WGTLTSLGST LPCRSLSSHK LPWVTVSHHD
510 520 530 540 550
PEVPFNHSFI EPPSAGWATD DSFSSDPESG EADEVPAYCV PPQEGMVPVA
560 570 580 590 600
QAGSSEASLA AGAFPPPEDA STPFAIPRTS SLARAKRPSV SFAEGTKFAP
610 620 630 640 650
QSRRSSGELS SPLRKPKRLS RGAQSGPEGR EAEESTGPEE AEAPESFPAA
660 670 680 690 700
ASPGDSATGH RRPPLGGRTV AEHVEAIEGS VQESSGPVTT IYMLAGKPRG
710 720 730 740 750
SEGPVRSVFR HFGSFQKGQA EAKVKRAIPK PPRQALNRKK GSPGLASGSV
760 770 780 790 800
GQSPNSAPKA GLPGATGPMA VRPEEAVRGL GAGTESSRRA QEPVSGCGSP
810 820 830
EQDPQKQAEE ERQEEPEYEN VVPISRPPEP
Length:830
Mass (Da):87,387
Last modified:November 2, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3D1CBF0D6F2BA055
GO
Isoform 2 (identifier: Q14162-2) [UniParc]FASTAAdd to basket
Also known as: SREC-5

The sequence of this isoform differs from the canonical sequence as follows:
     330-415: Missing.

Show »
Length:744
Mass (Da):78,783
Checksum:iA924B3B4B76D6948
GO
Isoform 3 (identifier: Q14162-3) [UniParc]FASTAAdd to basket
Also known as: SREC-3

The sequence of this isoform differs from the canonical sequence as follows:
     496-569: VSHHDPEVPF...AAGAFPPPED → ASSSRPLPAG...RHSPSRAPPA
     570-830: Missing.

Show »
Length:569
Mass (Da):60,820
Checksum:i3ACECF49DBC21675
GO
Isoform 4 (identifier: Q14162-4) [UniParc]FASTAAdd to basket
Also known as: SREC-4

The sequence of this isoform differs from the canonical sequence as follows:
     338-830: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:337
Mass (Da):36,240
Checksum:iB5F0FAE77445A44D
GO
Isoform 5 (identifier: Q14162-5) [UniParc]FASTAAdd to basket
Also known as: SREC-2

The sequence of this isoform differs from the canonical sequence as follows:
     338-342: CEDPC → GPVIL
     343-830: Missing.

Note: No experimental confirmation available.
Show »
Length:342
Mass (Da):36,720
Checksum:iE177E94FCE55F0FA
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MR54A0A0A0MR54_HUMAN
Scavenger receptor class F member 1
SCARF1
744Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L4R9I3L4R9_HUMAN
Scavenger receptor class F member 1
SCARF1
49Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti328 – 329RC → PG in BAC02696 (PubMed:11978792).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_047249425A → V5 PublicationsCorresponds to variant dbSNP:rs2272011Ensembl.1
Natural variantiVAR_047250618R → K. Corresponds to variant dbSNP:rs35455643Ensembl.1
Natural variantiVAR_047251639E → D4 PublicationsCorresponds to variant dbSNP:rs3744644Ensembl.1
Natural variantiVAR_047252662R → W2 PublicationsCorresponds to variant dbSNP:rs8072430Ensembl.1
Natural variantiVAR_047253667G → S4 PublicationsCorresponds to variant dbSNP:rs4790250Ensembl.1
Natural variantiVAR_047254748G → V. Corresponds to variant dbSNP:rs3760460Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_039956330 – 415Missing in isoform 2. 1 PublicationAdd BLAST86
Alternative sequenceiVSP_039957338 – 830Missing in isoform 4. 1 PublicationAdd BLAST493
Alternative sequenceiVSP_039958338 – 342CEDPC → GPVIL in isoform 5. 1 Publication5
Alternative sequenceiVSP_039959343 – 830Missing in isoform 5. 1 PublicationAdd BLAST488
Alternative sequenceiVSP_039960496 – 569VSHHD…PPPED → ASSSRPLPAGPLMTPSHPIL SLERQMRFLPTVCHPKKGWS LWPRQGRQRPAWLQVLSRPL RTPPRHSPSRAPPA in isoform 3. 1 PublicationAdd BLAST74
Alternative sequenceiVSP_039961570 – 830Missing in isoform 3. 1 PublicationAdd BLAST261

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
D86864 mRNA Translation: BAA24070.1
AB052946 Genomic DNA Translation: BAC02692.1
AB052947 mRNA Translation: BAC02693.1
AB052948 mRNA Translation: BAC02694.1
AB052949 mRNA Translation: BAC02695.1
AB052950 mRNA Translation: BAC02696.1
D63483 mRNA Translation: BAA09770.1
AC130343 Genomic DNA No translation available.
CH471108 Genomic DNA Translation: EAW90596.1
BC039735 mRNA Translation: AAH39735.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS11007.1 [Q14162-1]
CCDS45564.1 [Q14162-3]

NCBI Reference Sequences

More...
RefSeqi
NP_003684.2, NM_003693.3 [Q14162-1]
NP_663325.1, NM_145350.2 [Q14162-3]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.647430

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000263071; ENSP00000263071; ENSG00000074660 [Q14162-1]
ENST00000434376; ENSP00000411167; ENSG00000074660 [Q14162-5]
ENST00000571272; ENSP00000458174; ENSG00000074660 [Q14162-3]
ENST00000621348; ENSP00000481595; ENSG00000276336 [Q14162-1]
ENST00000631462; ENSP00000487665; ENSG00000276336 [Q14162-5]
ENST00000632317; ENSP00000488776; ENSG00000276336 [Q14162-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
8578

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:8578

UCSC genome browser

More...
UCSCi
uc002fsy.3 human [Q14162-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D86864 mRNA Translation: BAA24070.1
AB052946 Genomic DNA Translation: BAC02692.1
AB052947 mRNA Translation: BAC02693.1
AB052948 mRNA Translation: BAC02694.1
AB052949 mRNA Translation: BAC02695.1
AB052950 mRNA Translation: BAC02696.1
D63483 mRNA Translation: BAA09770.1
AC130343 Genomic DNA No translation available.
CH471108 Genomic DNA Translation: EAW90596.1
BC039735 mRNA Translation: AAH39735.1
CCDSiCCDS11007.1 [Q14162-1]
CCDS45564.1 [Q14162-3]
RefSeqiNP_003684.2, NM_003693.3 [Q14162-1]
NP_663325.1, NM_145350.2 [Q14162-3]
UniGeneiHs.647430

3D structure databases

ProteinModelPortaliQ14162
SMRiQ14162
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ14162, 17 interactors
STRINGi9606.ENSP00000263071

PTM databases

iPTMnetiQ14162
PhosphoSitePlusiQ14162
SwissPalmiQ14162

Polymorphism and mutation databases

BioMutaiSCARF1
DMDMi311033530

Proteomic databases

jPOSTiQ14162
PaxDbiQ14162
PeptideAtlasiQ14162
PRIDEiQ14162
ProteomicsDBi59887
59888 [Q14162-2]
59889 [Q14162-3]
59890 [Q14162-4]
59891 [Q14162-5]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000263071; ENSP00000263071; ENSG00000074660 [Q14162-1]
ENST00000434376; ENSP00000411167; ENSG00000074660 [Q14162-5]
ENST00000571272; ENSP00000458174; ENSG00000074660 [Q14162-3]
ENST00000621348; ENSP00000481595; ENSG00000276336 [Q14162-1]
ENST00000631462; ENSP00000487665; ENSG00000276336 [Q14162-5]
ENST00000632317; ENSP00000488776; ENSG00000276336 [Q14162-3]
GeneIDi8578
KEGGihsa:8578
UCSCiuc002fsy.3 human [Q14162-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
8578
EuPathDBiHostDB:ENSG00000074660.15

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SCARF1

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0013404
HGNCiHGNC:16820 SCARF1
HPAiHPA072936
MIMi607873 gene
neXtProtiNX_Q14162
OpenTargetsiENSG00000074660
PharmGKBiPA38420

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1218 Eukaryota
ENOG410XQWV LUCA
GeneTreeiENSGT00950000183101
HOGENOMiHOG000015093
HOVERGENiHBG099941
InParanoidiQ14162
OMAiCVPPQEG
OrthoDBi110992at2759
PhylomeDBiQ14162
TreeFamiTF332598

Enzyme and pathway databases

ReactomeiR-HSA-3000484 Scavenging by Class F Receptors

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
8578

Protein Ontology

More...
PROi
PR:Q14162

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000074660 Expressed in 159 organ(s), highest expression level in spleen
ExpressionAtlasiQ14162 baseline and differential
GenevisibleiQ14162 HS

Family and domain databases

InterProiView protein in InterPro
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR009030 Growth_fac_rcpt_cys_sf
IPR002049 Laminin_EGF
IPR033329 SCARF1
PANTHERiPTHR24043:SF0 PTHR24043:SF0, 1 hit
PfamiView protein in Pfam
PF00053 Laminin_EGF, 2 hits
SMARTiView protein in SMART
SM00181 EGF, 9 hits
SUPFAMiSSF57184 SSF57184, 1 hit
PROSITEiView protein in PROSITE
PS00022 EGF_1, 6 hits
PS01186 EGF_2, 6 hits
PS50026 EGF_3, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSREC_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q14162
Secondary accession number(s): A8MQ05
, O43701, Q8NHD2, Q8NHD3, Q8NHD4, Q8NHD5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: November 2, 2010
Last modified: April 10, 2019
This is version 168 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again