Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 196 (16 Oct 2019)
Sequence version 2 (18 Oct 2001)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

ARF GTPase-activating protein GIT2

Gene

GIT2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

GTPase-activating protein for the ADP ribosylation factor family.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri11 – 34C4-typePROSITE-ProRule annotationAdd BLAST24

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGTPase activation
LigandMetal-binding, Zinc

Enzyme and pathway databases

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q14161

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
ARF GTPase-activating protein GIT2
Short name:
ARF GAP GIT2
Alternative name(s):
Cool-interacting tyrosine-phosphorylated protein 2
Short name:
CAT-2
Short name:
CAT2
G protein-coupled receptor kinase-interactor 2
GRK-interacting protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GIT2
Synonyms:KIAA0148
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:4273 GIT2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
608564 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q14161

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
9815

Open Targets

More...
OpenTargetsi
ENSG00000139436

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA28684

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q14161

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
GIT2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
17376322

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000742031 – 759ARF GTPase-activating protein GIT2Add BLAST759

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei394PhosphoserineCombined sources1
Modified residuei397PhosphoserineCombined sources1
Modified residuei401PhosphothreonineBy similarity1
Modified residuei415PhosphoserineCombined sources1
Modified residuei418PhosphoserineCombined sources1
Modified residuei421PhosphoserineCombined sources1
Modified residuei484PhosphotyrosineCombined sources1
Modified residuei559PhosphoserineCombined sources1
Modified residuei562PhosphoserineBy similarity1
Modified residuei570PhosphoserineBy similarity1
Modified residuei587PhosphothreonineBy similarity1
Modified residuei614PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q14161

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q14161

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q14161

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q14161

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q14161

PeptideAtlas

More...
PeptideAtlasi
Q14161

PRoteomics IDEntifications database

More...
PRIDEi
Q14161

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
59876 [Q14161-1]
59877 [Q14161-10]
59878 [Q14161-11]
59879 [Q14161-2]
59880 [Q14161-3]
59881 [Q14161-4]
59882 [Q14161-5]
59883 [Q14161-6]
59884 [Q14161-7]
59885 [Q14161-8]
59886 [Q14161-9]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q14161

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q14161

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000139436 Expressed in 207 organ(s), highest expression level in right hemisphere of cerebellum

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q14161 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q14161 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB004681

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with TGFB1I1 (By similarity).

Interacts with G protein-coupled receptor kinases. Associates with paxillin.

Also interacts with PIX exchange factors.

Identified in a complex with ARHGEF6 and BIN2.

By similarity2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
115154, 96 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q14161

Protein interaction database and analysis system

More...
IntActi
Q14161, 62 interactors

Molecular INTeraction database

More...
MINTi
Q14161

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000347464

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q14161

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 124Arf-GAPPROSITE-ProRule annotationAdd BLAST124
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati132 – 161ANK 1Add BLAST30
Repeati166 – 195ANK 2Add BLAST30
Repeati199 – 228ANK 3Add BLAST30

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri11 – 34C4-typePROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

ANK repeat, Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0818 Eukaryota
ENOG410XR8U LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156383

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000232135

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q14161

KEGG Orthology (KO)

More...
KOi
K12487

Identification of Orthologs from Complete Genome Data

More...
OMAi
PASMYER

Database of Orthologous Groups

More...
OrthoDBi
349344at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q14161

TreeFam database of animal gene trees

More...
TreeFami
TF317762

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.20, 1 hit
3.30.40.160, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR037278 ARFGAP/RecO
IPR001164 ArfGAP_dom
IPR038508 ArfGAP_dom_sf
IPR032352 GIT1/2_CC
IPR022018 GIT1_C
IPR013724 GIT_SHD

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12796 Ank_2, 1 hit
PF01412 ArfGap, 1 hit
PF12205 GIT1_C, 1 hit
PF16559 GIT_CC, 1 hit
PF08518 GIT_SHD, 2 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00405 REVINTRACTNG

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248 ANK, 3 hits
SM00105 ArfGap, 1 hit
SM00555 GIT, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48403 SSF48403, 1 hit
SSF57863 SSF57863, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 1 hit
PS50115 ARFGAP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (11+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 11 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 11 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q14161-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSKRLRSSEV CADCSGPDPS WASVNRGTFL CDECCSVHRS LGRHISQVRH
60 70 80 90 100
LKHTPWPPTL LQMVETLYNN GANSIWEHSL LDPASIMSGR RKANPQDKVH
110 120 130 140 150
PNKAEFIRAK YQMLAFVHRL PCRDDDSVTA KDLSKQLHSS VRTGNLETCL
160 170 180 190 200
RLLSLGAQAN FFHPEKGNTP LHVASKAGQI LQAELLAVYG ADPGTQDSSG
210 220 230 240 250
KTPVDYARQG GHHELAERLV EIQYELTDRL AFYLCGRKPD HKNGQHFIIP
260 270 280 290 300
QMADSSLDLS ELAKAAKKKL QSLSNHLFEE LAMDVYDEVD RRETDAVWLA
310 320 330 340 350
TQNHSALVTE TTVVPFLPVN PEYSSTRNQG RQKLARFNAH EFATLVIDIL
360 370 380 390 400
SDAKRRQQGS SLSGSKDNVE LILKTINNQH SVESQDNDQP DYDSVASDED
410 420 430 440 450
TDLETTASKT NRQKSLDSDL SDGPVTVQEF MEVKNALVAS EAKIQQLMKV
460 470 480 490 500
NNNLSDELRI MQKKLQTLQS ENSNLRKQAT TNVYQVQTGS EYTDTSNHSS
510 520 530 540 550
LKRRPSARGS RPMSMYETGS GQKPYLPMGE ASRPEESRMR LQPFPAHIGR
560 570 580 590 600
SALVTSSSSL PSFPSTLSWS RDESARRASR LEKQNSTPES DYDNTPNDME
610 620 630 640 650
PDGMGSSRKG RQRSMVWPGD GLVPDTAEPH VAPSPTLPST EDVIRKTEQI
660 670 680 690 700
TKNIQELLRA AQENKHDSYI PCSERIHVAV TEMAALFPKK PKSDMVRTSL
710 720 730 740 750
RLLTSSAYRL QSECKKTLPG DPGSPTDVQL VTQQVIQCAY DIAKAAKQLV

TITTKENNN
Length:759
Mass (Da):84,543
Last modified:October 18, 2001 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i07EFE266DB2F3258
GO
Isoform 2 (identifier: Q14161-2) [UniParc]FASTAAdd to basket
Also known as: GIT2-short

The sequence of this isoform differs from the canonical sequence as follows:
     466-471: QTLQSE → LGKDAN
     472-759: Missing.

Show »
Length:471
Mass (Da):52,577
Checksum:i4C82BB94EA3634DA
GO
Isoform 3 (identifier: Q14161-3) [UniParc]FASTAAdd to basket
Also known as: C-

The sequence of this isoform differs from the canonical sequence as follows:
     450-464: Missing.

Show »
Length:744
Mass (Da):82,759
Checksum:iFE6EB7D7BA75DF1D
GO
Isoform 4 (identifier: Q14161-4) [UniParc]FASTAAdd to basket
Also known as: BC-

The sequence of this isoform differs from the canonical sequence as follows:
     415-449: Missing.
     450-464: Missing.

Show »
Length:709
Mass (Da):78,954
Checksum:i5D6679379A84F684
GO
Isoform 5 (identifier: Q14161-5) [UniParc]FASTAAdd to basket
Also known as: E-

The sequence of this isoform differs from the canonical sequence as follows:
     548-577: Missing.

Show »
Length:729
Mass (Da):81,322
Checksum:i6B3A644B9F357C11
GO
Isoform 6 (identifier: Q14161-6) [UniParc]FASTAAdd to basket
Also known as: CD-

The sequence of this isoform differs from the canonical sequence as follows:
     450-464: Missing.
     465-547: Missing.

Show »
Length:661
Mass (Da):73,403
Checksum:iDD63B22D57DE9FAA
GO
Isoform 7 (identifier: Q14161-7) [UniParc]FASTAAdd to basket
Also known as: DE-

The sequence of this isoform differs from the canonical sequence as follows:
     465-547: Missing.
     548-577: Missing.

Show »
Length:646
Mass (Da):71,967
Checksum:i5A146DE59620E062
GO
Isoform 8 (identifier: Q14161-8) [UniParc]FASTAAdd to basket
Also known as: BE-

The sequence of this isoform differs from the canonical sequence as follows:
     415-449: Missing.
     548-577: Missing.

Show »
Length:694
Mass (Da):77,518
Checksum:i40D620FE62406931
GO
Isoform 9 (identifier: Q14161-9) [UniParc]FASTAAdd to basket
Also known as: AE-

The sequence of this isoform differs from the canonical sequence as follows:
     334-414: Missing.
     548-577: Missing.

Show »
Length:648
Mass (Da):72,318
Checksum:i3FE0E683427F3E09
GO
Isoform 10 (identifier: Q14161-10) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     255-255: S → RRL
     414-463: Missing.
     548-577: Missing.

Note: No experimental confirmation available.
Show »
Length:681
Mass (Da):76,072
Checksum:iDADC7AB863457F3D
GO
Isoform 11 (identifier: Q14161-11) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     450-464: Missing.
     465-547: Missing.
     548-577: Missing.

Note: No experimental confirmation available.
Show »
Length:631
Mass (Da):70,183
Checksum:iC14DEB3FF1A577CD
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8VXI9F8VXI9_HUMAN
ARF GTPase-activating protein GIT2
GIT2
708Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WAK2F8WAK2_HUMAN
ARF GTPase-activating protein GIT2
GIT2
681Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
R4GNG3R4GNG3_HUMAN
ARF GTPase-activating protein GIT2
GIT2
641Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8W822F8W822_HUMAN
ARF GTPase-activating protein GIT2
GIT2
421Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA09769 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti285V → M in AAP35976 (Ref. 4) Curated1
Sequence conflicti285V → M in AAH01379 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_048324338N → S. Corresponds to variant dbSNP:rs9804905Ensembl.1
Natural variantiVAR_024368387N → S. Corresponds to variant dbSNP:rs925368Ensembl.1
Natural variantiVAR_048325552A → V. Corresponds to variant dbSNP:rs11068997Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_026456255S → RRL in isoform 10. 1 Publication1
Alternative sequenceiVSP_000305334 – 414Missing in isoform 9. 1 PublicationAdd BLAST81
Alternative sequenceiVSP_008654414 – 463Missing in isoform 10. 1 PublicationAdd BLAST50
Alternative sequenceiVSP_000306415 – 449Missing in isoform 4 and isoform 8. 1 PublicationAdd BLAST35
Alternative sequenceiVSP_000307450 – 464Missing in isoform 3, isoform 4, isoform 6 and isoform 11. 2 PublicationsAdd BLAST15
Alternative sequenceiVSP_000308465 – 547Missing in isoform 6, isoform 7 and isoform 11. 2 PublicationsAdd BLAST83
Alternative sequenceiVSP_000303466 – 471QTLQSE → LGKDAN in isoform 2. 3 Publications6
Alternative sequenceiVSP_000304472 – 759Missing in isoform 2. 3 PublicationsAdd BLAST288
Alternative sequenceiVSP_000309548 – 577Missing in isoform 5, isoform 7, isoform 8, isoform 9, isoform 10 and isoform 11. 3 PublicationsAdd BLAST30

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF124491 mRNA Translation: AAD28047.1
D63482 mRNA Translation: BAA09769.2 Different initiation.
BT007312 mRNA Translation: AAP35976.1
BC001379 mRNA Translation: AAH01379.1
BC014223 mRNA Translation: AAH14223.2

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS44968.1 [Q14161-5]
CCDS44969.1 [Q14161-11]
CCDS55884.1 [Q14161-10]
CCDS9138.1 [Q14161-1]
CCDS9139.1 [Q14161-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001128685.1, NM_001135213.2 [Q14161-10]
NP_001128686.1, NM_001135214.2 [Q14161-5]
NP_001317082.1, NM_001330153.1
NP_055591.2, NM_014776.4
NP_476510.1, NM_057169.4 [Q14161-1]
NP_476511.1, NM_057170.4 [Q14161-11]
XP_006719770.1, XM_006719707.3 [Q14161-3]
XP_006719772.1, XM_006719709.3 [Q14161-4]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000355312; ENSP00000347464; ENSG00000139436 [Q14161-1]
ENST00000361006; ENSP00000354282; ENSG00000139436 [Q14161-5]
ENST00000457474; ENSP00000391813; ENSG00000139436 [Q14161-10]
ENST00000547815; ENSP00000450348; ENSG00000139436 [Q14161-2]
ENST00000553118; ENSP00000447465; ENSG00000139436 [Q14161-11]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
9815

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:9815

UCSC genome browser

More...
UCSCi
uc001tpq.3 human [Q14161-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF124491 mRNA Translation: AAD28047.1
D63482 mRNA Translation: BAA09769.2 Different initiation.
BT007312 mRNA Translation: AAP35976.1
BC001379 mRNA Translation: AAH01379.1
BC014223 mRNA Translation: AAH14223.2
CCDSiCCDS44968.1 [Q14161-5]
CCDS44969.1 [Q14161-11]
CCDS55884.1 [Q14161-10]
CCDS9138.1 [Q14161-1]
CCDS9139.1 [Q14161-2]
RefSeqiNP_001128685.1, NM_001135213.2 [Q14161-10]
NP_001128686.1, NM_001135214.2 [Q14161-5]
NP_001317082.1, NM_001330153.1
NP_055591.2, NM_014776.4
NP_476510.1, NM_057169.4 [Q14161-1]
NP_476511.1, NM_057170.4 [Q14161-11]
XP_006719770.1, XM_006719707.3 [Q14161-3]
XP_006719772.1, XM_006719709.3 [Q14161-4]

3D structure databases

SMRiQ14161
ModBaseiSearch...

Protein-protein interaction databases

BioGridi115154, 96 interactors
CORUMiQ14161
IntActiQ14161, 62 interactors
MINTiQ14161
STRINGi9606.ENSP00000347464

PTM databases

iPTMnetiQ14161
PhosphoSitePlusiQ14161

Polymorphism and mutation databases

BioMutaiGIT2
DMDMi17376322

Proteomic databases

EPDiQ14161
jPOSTiQ14161
MassIVEiQ14161
MaxQBiQ14161
PaxDbiQ14161
PeptideAtlasiQ14161
PRIDEiQ14161
ProteomicsDBi59876 [Q14161-1]
59877 [Q14161-10]
59878 [Q14161-11]
59879 [Q14161-2]
59880 [Q14161-3]
59881 [Q14161-4]
59882 [Q14161-5]
59883 [Q14161-6]
59884 [Q14161-7]
59885 [Q14161-8]
59886 [Q14161-9]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
9815

Genome annotation databases

EnsembliENST00000355312; ENSP00000347464; ENSG00000139436 [Q14161-1]
ENST00000361006; ENSP00000354282; ENSG00000139436 [Q14161-5]
ENST00000457474; ENSP00000391813; ENSG00000139436 [Q14161-10]
ENST00000547815; ENSP00000450348; ENSG00000139436 [Q14161-2]
ENST00000553118; ENSP00000447465; ENSG00000139436 [Q14161-11]
GeneIDi9815
KEGGihsa:9815
UCSCiuc001tpq.3 human [Q14161-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9815
DisGeNETi9815

GeneCards: human genes, protein and diseases

More...
GeneCardsi
GIT2
HGNCiHGNC:4273 GIT2
HPAiCAB004681
MIMi608564 gene
neXtProtiNX_Q14161
OpenTargetsiENSG00000139436
PharmGKBiPA28684

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0818 Eukaryota
ENOG410XR8U LUCA
GeneTreeiENSGT00940000156383
HOGENOMiHOG000232135
InParanoidiQ14161
KOiK12487
OMAiPASMYER
OrthoDBi349344at2759
PhylomeDBiQ14161
TreeFamiTF317762

Enzyme and pathway databases

SIGNORiQ14161

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
GIT2 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
GIT2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
9815
PharosiQ14161

Protein Ontology

More...
PROi
PR:Q14161

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000139436 Expressed in 207 organ(s), highest expression level in right hemisphere of cerebellum
ExpressionAtlasiQ14161 baseline and differential
GenevisibleiQ14161 HS

Family and domain databases

Gene3Di1.25.40.20, 1 hit
3.30.40.160, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR037278 ARFGAP/RecO
IPR001164 ArfGAP_dom
IPR038508 ArfGAP_dom_sf
IPR032352 GIT1/2_CC
IPR022018 GIT1_C
IPR013724 GIT_SHD
PfamiView protein in Pfam
PF12796 Ank_2, 1 hit
PF01412 ArfGap, 1 hit
PF12205 GIT1_C, 1 hit
PF16559 GIT_CC, 1 hit
PF08518 GIT_SHD, 2 hits
PRINTSiPR00405 REVINTRACTNG
SMARTiView protein in SMART
SM00248 ANK, 3 hits
SM00105 ArfGap, 1 hit
SM00555 GIT, 2 hits
SUPFAMiSSF48403 SSF48403, 1 hit
SSF57863 SSF57863, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 1 hit
PS50115 ARFGAP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGIT2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q14161
Secondary accession number(s): Q86U59
, Q96CI2, Q9BV91, Q9Y5V2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: October 18, 2001
Last modified: October 16, 2019
This is version 196 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again