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UniProtKB - Q14157 (UBP2L_HUMAN)

Protein

Ubiquitin-associated protein 2-like

Gene

UBAP2L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays an important role in the activity of long-term repopulating hematopoietic stem cells (LT-HSCs).By similarity

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

  • binding of sperm to zona pellucida Source: UniProtKB
  • hematopoietic stem cell homeostasis Source: MGI
View the complete GO annotation on QuickGO ...

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-associated protein 2-like
Alternative name(s):
Protein NICE-4
Gene namesi
Name:UBAP2L
Synonyms:KIAA0144, NICE4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000143569.18
HGNCiHGNC:29877 UBAP2L
MIMi616472 gene
neXtProtiNX_Q14157

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi9898
OpenTargetsiENSG00000143569
PharmGKBiPA134883839

Polymorphism and mutation databases

BioMutaiUBAP2L
DMDMi109940042

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002110201 – 1087Ubiquitin-associated protein 2-likeAdd BLAST1087

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei187Asymmetric dimethylarginineCombined sources1
Modified residuei190Asymmetric dimethylarginineCombined sources1
Modified residuei356PhosphoserineCombined sources1
Modified residuei360PhosphoserineCombined sources1
Modified residuei410PhosphoserineCombined sources1
Modified residuei416PhosphoserineCombined sources1
Modified residuei425PhosphothreonineCombined sources1
Modified residuei439PhosphoserineCombined sources1
Modified residuei454PhosphoserineCombined sources1
Modified residuei467PhosphoserineCombined sources1
Modified residuei470PhosphoserineCombined sources1
Modified residuei471PhosphoserineCombined sources1
Modified residuei477PhosphoserineCombined sources1
Modified residuei604PhosphoserineCombined sources1
Modified residuei605PhosphoserineCombined sources1
Modified residuei608PhosphoserineCombined sources1
Modified residuei609PhosphoserineCombined sources1
Modified residuei852PhosphoserineCombined sources1
Modified residuei859PhosphoserineCombined sources1
Isoform 4 (identifier: Q14157-4)
Modified residuei962Omega-N-methylarginineCombined sources1
Modified residuei969N6-acetyllysineCombined sources1
Isoform 2 (identifier: Q14157-1)
Modified residuei969Omega-N-methylarginineCombined sources1
Modified residuei976N6-acetyllysineCombined sources1

Post-translational modificationi

Acetylated.

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

EPDiQ14157
PaxDbiQ14157
PeptideAtlasiQ14157
PRIDEiQ14157
ProteomicsDBi59867
59868 [Q14157-1]
59869 [Q14157-3]
59870 [Q14157-4]
59871 [Q14157-5]

PTM databases

iPTMnetiQ14157
PhosphoSitePlusiQ14157

Miscellaneous databases

PMAP-CutDBiQ14157

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

BgeeiENSG00000143569 Expressed in 232 organ(s), highest expression level in left lobe of thyroid gland
CleanExiHS_UBAP2L
ExpressionAtlasiQ14157 baseline and differential
GenevisibleiQ14157 HS

Organism-specific databases

HPAiHPA035068

Interactioni

Subunit structurei

Interacts with BMI1 (PubMed:25185265). Part of a complex consisting of UBAP2L, BMI1 and RNF2(PubMed:25185265).1 Publication

Protein-protein interaction databases

BioGridi115227, 60 interactors
CORUMiQ14157
IntActiQ14157, 21 interactors
MINTiQ14157
STRINGi9606.ENSP00000355343

Structurei

3D structure databases

ProteinModelPortaliQ14157
SMRiQ14157
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini49 – 89UBAPROSITE-ProRule annotationAdd BLAST41

Phylogenomic databases

eggNOGiENOG410IGWX Eukaryota
ENOG4110RI8 LUCA
GeneTreeiENSGT00390000003453
HOGENOMiHOG000138192
HOVERGENiHBG090480
InParanoidiQ14157
OMAiQTRRYPN
OrthoDBiEOG091G0GRY
PhylomeDBiQ14157
TreeFamiTF328468

Family and domain databases

InterProiView protein in InterPro
IPR022166 DUF3697_Uba2
IPR015940 UBA
IPR009060 UBA-like_sf
PfamiView protein in Pfam
PF12478 DUF3697, 1 hit
SMARTiView protein in SMART
SM00165 UBA, 1 hit
SUPFAMiSSF46934 SSF46934, 1 hit
PROSITEiView protein in PROSITE
PS50030 UBA, 1 hit

Sequences (5+)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q14157-2) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MMTSVGTNRA RGNWEQPQNQ NQTQHKQRPQ ATAEQIRLAQ MISDHNDADF 
        60         70         80         90        100
EEKVKQLIDI TGKNQDECVI ALHDCNGDVN RAINVLLEGN PDTHSWEMVG 
       110        120        130        140        150
KKKGVSGQKD GGQTESNEEG KENRDRDRDY SRRRGGPPRR GRGASRGREF 
       160        170        180        190        200
RGQENGLDGT KSGGPSGRGT ERGRRGRGRG RGGSGRRGGR FSAQGMGTFN 
       210        220        230        240        250
PADYAEPANT DDNYGNSSGN TWNNTGHFEP DDGTSAWRTA TEEWGTEDWN 
       260        270        280        290        300
EDLSETKIFT ASNVSSVPLP AENVTITAGQ RIDLAVLLGK TPSTMENDSS 
       310        320        330        340        350
NLDPSQAPSL AQPLVFSNSK QTAISQPASG NTFSHHSMVS MLGKGFGDVG 
       360        370        380        390        400
EAKGGSTTGS QFLEQFKTAQ ALAQLAAQHS QSGSTTTSSW DMGSTTQSPS 
       410        420        430        440        450
LVQYDLKNPS DSAVHSPFTK RQAFTPSSTM MEVFLQEKSP AVATSTAAPP 
       460        470        480        490        500
PPSSPLPSKS TSAPQMSPGS SDNQSSSPQP AQQKLKQQKK KASLTSKIPA 
       510        520        530        540        550
LAVEMPGSAD ISGLNLQFGA LQFGSEPVLS DYESTPTTSA SSSQAPSSLY 
       560        570        580        590        600
TSTASESSST ISSNQSQESG YQSGPIQSTT YTSQNNAQGP LYEQRSTQTR 
       610        620        630        640        650
RYPSSISSSP QKDLTQAKNG FSSVQATQLQ TTQSVEGATG SAVKSDSPST 
       660        670        680        690        700
SSIPPLNETV SAASLLTTTN QHSSSLGGLS HSEEIPNTTT TQHSSTLSTQ 
       710        720        730        740        750
QNTLSSSTSS GRTSTSTLLH TSVESEANLH SSSSTFSTTS STVSAPPPVV 
       760        770        780        790        800
SVSSSLNSGS SLGLSLGSNS TVTASTRSSV ATTSGKAPPN LPPGVPPLLP 
       810        820        830        840        850
NPYIMAPGLL HAYPPQVYGY DDLQMLQTRF PLDYYSIPFP TPTTPLTGRD 
       860        870        880        890        900
GSLASNPYSG DLTKFGRGDA SSPAPATTLA QPQQNQTQTH HTTQQTFLNP 
       910        920        930        940        950
ALPPGYSYTS LPYYTGVPGL PSTFQYGPAV FPVAPTSSKQ HGVNVSVNAS 
       960        970        980        990       1000
ATPFQQPSGY GSHGYNTGVS VTSSNTGVPD ISGSVYSKTQ QSFEKQGFHS 
      1010       1020       1030       1040       1050
GTPAASFNLP SALGSGGPIN PATAAAYPPA PFMHILTPHQ QPHSQILHHH 
      1060       1070       1080 
LQQDGQTGSG QRSQTSSIPQ KPQTNKSAYN SYSWGAN
Length:1,087
Mass (Da):114,535
Last modified:June 27, 2006 - v2
Checksum:iFED18847387AA1F5
GO
Isoform 2 (identifier: Q14157-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     969-1087: VSVTSSNTGV...AYNSYSWGAN → RKYPPPYKHFWTAES

Show »
Length:983
Mass (Da):103,930
Checksum:i50579CFA293EEA68
GO
Isoform 3 (identifier: Q14157-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1057-1087: TGSGQRSQTSSIPQKPQTNKSAYNSYSWGAN → DILNFVDDQLGE

Show »
Length:1,068
Mass (Da):112,580
Checksum:i86703186E7D5FC73
GO
Isoform 4 (identifier: Q14157-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     143-150: GASRGREF → V
     969-1087: VSVTSSNTGV...AYNSYSWGAN → RKYPPPYKHFWTAES

Note: No experimental confirmation available.Combined sources
Show »
Length:976
Mass (Da):103,168
Checksum:iBF593BEA38DF9579
GO
Isoform 5 (identifier: Q14157-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1055-1055: G → GQLPYLQMILCCQRQQEE

Show »
Length:1,104
Mass (Da):116,640
Checksum:iA361FC99B94E0988
GO

Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8W726F8W726_HUMAN
Ubiquitin-associated protein 2-like
UBAP2L
1,079Annotation score:
Q5VU77Q5VU77_HUMAN
Ubiquitin-associated protein 2-like
UBAP2L
350Annotation score:
Q5VU81Q5VU81_HUMAN
Ubiquitin-associated protein 2-like
UBAP2L
182Annotation score:
Q5VU80Q5VU80_HUMAN
Ubiquitin-associated protein 2-like
UBAP2L
234Annotation score:
Q5VU78Q5VU78_HUMAN
Ubiquitin-associated protein 2-like
UBAP2L
280Annotation score:
Q5VU79Q5VU79_HUMAN
Ubiquitin-associated protein 2-like
UBAP2L
265Annotation score:
H0Y5H6H0Y5H6_HUMAN
Ubiquitin-associated protein 2-like
UBAP2L
383Annotation score:
H7C2T8H7C2T8_HUMAN
Ubiquitin-associated protein 2-like
UBAP2L
399Annotation score:

Sequence cautioni

The sequence CAB65100 differs from that shown. Reason: Frameshift at position 1085.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti91P → S in BAG64560 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_026829482Q → H. Corresponds to variant dbSNP:rs17849745Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_038235143 – 150GASRGREF → V in isoform 4. 1 Publication8
Alternative sequenceiVSP_019417969 – 1087VSVTS…SWGAN → RKYPPPYKHFWTAES in isoform 2 and isoform 4. 2 PublicationsAdd BLAST119
Alternative sequenceiVSP_0421671055G → GQLPYLQMILCCQRQQEE in isoform 5. 1 Publication1
Alternative sequenceiVSP_0217281057 – 1087TGSGQ…SWGAN → DILNFVDDQLGE in isoform 3. 1 PublicationAdd BLAST31

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D63478 mRNA Translation: BAA09765.1
AK303533 mRNA Translation: BAG64560.1
AL590431 Genomic DNA No translation available.
BC003170 mRNA Translation: AAH03170.1
AJ243668 mRNA Translation: CAB65099.1
AJ243670 mRNA Translation: CAB65101.2
AJ243669 mRNA Translation: CAB65100.2 Frameshift.
CCDSiCCDS1063.1 [Q14157-2]
CCDS44229.1 [Q14157-1]
CCDS72925.1 [Q14157-4]
RefSeqiNP_001120792.1, NM_001127320.2 [Q14157-1]
NP_001274744.1, NM_001287815.1 [Q14157-4]
NP_001274745.1, NM_001287816.1
NP_055662.3, NM_014847.3 [Q14157-2]
XP_005245731.1, XM_005245674.1 [Q14157-1]
XP_011508518.1, XM_011510216.1 [Q14157-5]
XP_016858467.1, XM_017002978.1 [Q14157-2]
XP_016858468.1, XM_017002979.1 [Q14157-2]
XP_016858475.1, XM_017002986.1 [Q14157-3]
XP_016858476.1, XM_017002987.1 [Q14157-3]
XP_016858478.1, XM_017002989.1 [Q14157-1]
XP_016858479.1, XM_017002990.1 [Q14157-1]
UniGeneiHs.490551

Genome annotation databases

EnsembliENST00000343815; ENSP00000345308; ENSG00000143569 [Q14157-1]
ENST00000361546; ENSP00000355343; ENSG00000143569 [Q14157-2]
ENST00000428931; ENSP00000389445; ENSG00000143569 [Q14157-2]
ENST00000613315; ENSP00000478447; ENSG00000143569 [Q14157-4]
GeneIDi9898
KEGGihsa:9898
UCSCiuc001fep.5 human [Q14157-2]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D63478 mRNA Translation: BAA09765.1
AK303533 mRNA Translation: BAG64560.1
AL590431 Genomic DNA No translation available.
BC003170 mRNA Translation: AAH03170.1
AJ243668 mRNA Translation: CAB65099.1
AJ243670 mRNA Translation: CAB65101.2
AJ243669 mRNA Translation: CAB65100.2 Frameshift.
CCDSiCCDS1063.1 [Q14157-2]
CCDS44229.1 [Q14157-1]
CCDS72925.1 [Q14157-4]
RefSeqiNP_001120792.1, NM_001127320.2 [Q14157-1]
NP_001274744.1, NM_001287815.1 [Q14157-4]
NP_001274745.1, NM_001287816.1
NP_055662.3, NM_014847.3 [Q14157-2]
XP_005245731.1, XM_005245674.1 [Q14157-1]
XP_011508518.1, XM_011510216.1 [Q14157-5]
XP_016858467.1, XM_017002978.1 [Q14157-2]
XP_016858468.1, XM_017002979.1 [Q14157-2]
XP_016858475.1, XM_017002986.1 [Q14157-3]
XP_016858476.1, XM_017002987.1 [Q14157-3]
XP_016858478.1, XM_017002989.1 [Q14157-1]
XP_016858479.1, XM_017002990.1 [Q14157-1]
UniGeneiHs.490551

3D structure databases

ProteinModelPortaliQ14157
SMRiQ14157
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115227, 60 interactors
CORUMiQ14157
IntActiQ14157, 21 interactors
MINTiQ14157
STRINGi9606.ENSP00000355343

PTM databases

iPTMnetiQ14157
PhosphoSitePlusiQ14157

Polymorphism and mutation databases

BioMutaiUBAP2L
DMDMi109940042

Proteomic databases

EPDiQ14157
PaxDbiQ14157
PeptideAtlasiQ14157
PRIDEiQ14157
ProteomicsDBi59867
59868 [Q14157-1]
59869 [Q14157-3]
59870 [Q14157-4]
59871 [Q14157-5]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000343815; ENSP00000345308; ENSG00000143569 [Q14157-1]
ENST00000361546; ENSP00000355343; ENSG00000143569 [Q14157-2]
ENST00000428931; ENSP00000389445; ENSG00000143569 [Q14157-2]
ENST00000613315; ENSP00000478447; ENSG00000143569 [Q14157-4]
GeneIDi9898
KEGGihsa:9898
UCSCiuc001fep.5 human [Q14157-2]

Organism-specific databases

CTDi9898
DisGeNETi9898
EuPathDBiHostDB:ENSG00000143569.18
GeneCardsiUBAP2L
H-InvDBiHIX0001103
HGNCiHGNC:29877 UBAP2L
HPAiHPA035068
MIMi616472 gene
neXtProtiNX_Q14157
OpenTargetsiENSG00000143569
PharmGKBiPA134883839
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGWX Eukaryota
ENOG4110RI8 LUCA
GeneTreeiENSGT00390000003453
HOGENOMiHOG000138192
HOVERGENiHBG090480
InParanoidiQ14157
OMAiQTRRYPN
OrthoDBiEOG091G0GRY
PhylomeDBiQ14157
TreeFamiTF328468

Miscellaneous databases

ChiTaRSiUBAP2L human
GeneWikiiUBAP2L
GenomeRNAii9898
PMAP-CutDBiQ14157
PROiPR:Q14157
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000143569 Expressed in 232 organ(s), highest expression level in left lobe of thyroid gland
CleanExiHS_UBAP2L
ExpressionAtlasiQ14157 baseline and differential
GenevisibleiQ14157 HS

Family and domain databases

InterProiView protein in InterPro
IPR022166 DUF3697_Uba2
IPR015940 UBA
IPR009060 UBA-like_sf
PfamiView protein in Pfam
PF12478 DUF3697, 1 hit
SMARTiView protein in SMART
SM00165 UBA, 1 hit
SUPFAMiSSF46934 SSF46934, 1 hit
PROSITEiView protein in PROSITE
PS50030 UBA, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiUBP2L_HUMAN
AccessioniPrimary (citable) accession number: Q14157
Secondary accession number(s): B4E0U8
, Q5VU75, Q5VU76, Q9BTU3, Q9UGL2, Q9UGL3, Q9UGL4, Q9UGL5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: June 27, 2006
Last modified: November 7, 2018
This is version 162 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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