UniProtKB - Q14157 (UBP2L_HUMAN)
Protein
Ubiquitin-associated protein 2-like
Gene
UBAP2L
Organism
Homo sapiens (Human)
Status
Functioni
Plays an important role in the activity of long-term repopulating hematopoietic stem cells (LT-HSCs). Required for efficient formation of stress granules (PubMed:29395067).By similarity1 Publication
GO - Molecular functioni
- RNA binding Source: UniProtKB
GO - Biological processi
- binding of sperm to zona pellucida Source: UniProtKB
- hematopoietic stem cell homeostasis Source: MGI
- stress granule assembly Source: UniProtKB
Enzyme and pathway databases
PathwayCommonsi | Q14157 |
SIGNORi | Q14157 |
Names & Taxonomyi
Protein namesi | Recommended name: Ubiquitin-associated protein 2-likeCuratedAlternative name(s): Protein NICE-4 |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:29877, UBAP2L |
MIMi | 616472, gene |
neXtProti | NX_Q14157 |
VEuPathDBi | HostDB:ENSG00000143569.18 |
Subcellular locationi
Other locations
- Stress granule 1 Publication
Nucleus
- nucleus Source: GO_Central
- PcG protein complex Source: MGI
Other locations
- cytoplasm Source: GO_Central
- cytoplasmic stress granule Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Organism-specific databases
DisGeNETi | 9898 |
OpenTargetsi | ENSG00000143569 |
PharmGKBi | PA134883839 |
Miscellaneous databases
Pharosi | Q14157, Tbio |
Chemistry databases
ChEMBLi | CHEMBL4295819 |
Genetic variation databases
BioMutai | UBAP2L |
DMDMi | 109940042 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000211020 | 1 – 1087 | Ubiquitin-associated protein 2-likeAdd BLAST | 1087 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineCombined sources | 1 | ||
Modified residuei | 187 | Asymmetric dimethylarginineCombined sources | 1 | ||
Modified residuei | 190 | Asymmetric dimethylarginineCombined sources | 1 | ||
Modified residuei | 356 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 360 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 410 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 416 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 425 | PhosphothreonineCombined sources | 1 | ||
Modified residuei | 439 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 454 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 467 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 470 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 471 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 477 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 604 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 605 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 608 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 609 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 852 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 859 | PhosphoserineCombined sources | 1 | ||
Isoform 4 (identifier: Q14157-4) | |||||
Modified residuei | 962 | Omega-N-methylarginineCombined sources | 1 | ||
Modified residuei | 969 | N6-acetyllysineCombined sources | 1 | ||
Isoform 2 (identifier: Q14157-1) | |||||
Modified residuei | 969 | Omega-N-methylarginineCombined sources | 1 | ||
Modified residuei | 976 | N6-acetyllysineCombined sources | 1 |
Post-translational modificationi
Acetylated.
Keywords - PTMi
Acetylation, Methylation, PhosphoproteinProteomic databases
CPTACi | CPTAC-599 CPTAC-600 |
EPDi | Q14157 |
jPOSTi | Q14157 |
MassIVEi | Q14157 |
PaxDbi | Q14157 |
PeptideAtlasi | Q14157 |
PRIDEi | Q14157 |
ProteomicsDBi | 59867 [Q14157-2] 59868 [Q14157-1] 59869 [Q14157-3] 59870 [Q14157-4] 59871 [Q14157-5] |
PTM databases
GlyConnecti | 2895, 1 O-Linked glycan (2 sites) |
GlyGeni | Q14157, 11 sites, 1 O-linked glycan (9 sites) |
iPTMneti | Q14157 |
MetOSitei | Q14157 |
PhosphoSitePlusi | Q14157 |
Expressioni
Tissue specificityi
Ubiquitous.1 Publication
Gene expression databases
Bgeei | ENSG00000143569, Expressed in left lobe of thyroid gland and 241 other tissues |
ExpressionAtlasi | Q14157, baseline and differential |
Genevisiblei | Q14157, HS |
Organism-specific databases
HPAi | ENSG00000143569, Low tissue specificity |
Interactioni
Subunit structurei
Binary interactionsi
Hide detailsQ14157
With | #Exp. | IntAct |
---|---|---|
FXR1 - isoform 2 [P51114-2] | 3 | EBI-347762,EBI-11022345 |
FXR2 [P51116] | 4 | EBI-347762,EBI-740459 |
Protein-protein interaction databases
BioGRIDi | 115227, 199 interactors |
CORUMi | Q14157 |
IntActi | Q14157, 34 interactors |
MINTi | Q14157 |
STRINGi | 9606.ENSP00000389445 |
Miscellaneous databases
RNActi | Q14157, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 49 – 89 | UBAPROSITE-ProRule annotationAdd BLAST | 41 |
Phylogenomic databases
eggNOGi | ENOG502QPRH, Eukaryota |
GeneTreei | ENSGT00390000003453 |
HOGENOMi | CLU_009850_0_0_1 |
InParanoidi | Q14157 |
OMAi | VKTEWEV |
OrthoDBi | 234795at2759 |
PhylomeDBi | Q14157 |
TreeFami | TF328468 |
Family and domain databases
InterProi | View protein in InterPro IPR015940, UBA IPR009060, UBA-like_sf IPR022166, UBAP2/Lig |
Pfami | View protein in Pfam PF12478, DUF3697, 1 hit |
SMARTi | View protein in SMART SM00165, UBA, 1 hit |
SUPFAMi | SSF46934, SSF46934, 1 hit |
PROSITEi | View protein in PROSITE PS50030, UBA, 1 hit |
s (5+)i Sequence
Sequence statusi: Complete.
This entry describes 5 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 5 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q14157-2) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MMTSVGTNRA RGNWEQPQNQ NQTQHKQRPQ ATAEQIRLAQ MISDHNDADF
60 70 80 90 100
EEKVKQLIDI TGKNQDECVI ALHDCNGDVN RAINVLLEGN PDTHSWEMVG
110 120 130 140 150
KKKGVSGQKD GGQTESNEEG KENRDRDRDY SRRRGGPPRR GRGASRGREF
160 170 180 190 200
RGQENGLDGT KSGGPSGRGT ERGRRGRGRG RGGSGRRGGR FSAQGMGTFN
210 220 230 240 250
PADYAEPANT DDNYGNSSGN TWNNTGHFEP DDGTSAWRTA TEEWGTEDWN
260 270 280 290 300
EDLSETKIFT ASNVSSVPLP AENVTITAGQ RIDLAVLLGK TPSTMENDSS
310 320 330 340 350
NLDPSQAPSL AQPLVFSNSK QTAISQPASG NTFSHHSMVS MLGKGFGDVG
360 370 380 390 400
EAKGGSTTGS QFLEQFKTAQ ALAQLAAQHS QSGSTTTSSW DMGSTTQSPS
410 420 430 440 450
LVQYDLKNPS DSAVHSPFTK RQAFTPSSTM MEVFLQEKSP AVATSTAAPP
460 470 480 490 500
PPSSPLPSKS TSAPQMSPGS SDNQSSSPQP AQQKLKQQKK KASLTSKIPA
510 520 530 540 550
LAVEMPGSAD ISGLNLQFGA LQFGSEPVLS DYESTPTTSA SSSQAPSSLY
560 570 580 590 600
TSTASESSST ISSNQSQESG YQSGPIQSTT YTSQNNAQGP LYEQRSTQTR
610 620 630 640 650
RYPSSISSSP QKDLTQAKNG FSSVQATQLQ TTQSVEGATG SAVKSDSPST
660 670 680 690 700
SSIPPLNETV SAASLLTTTN QHSSSLGGLS HSEEIPNTTT TQHSSTLSTQ
710 720 730 740 750
QNTLSSSTSS GRTSTSTLLH TSVESEANLH SSSSTFSTTS STVSAPPPVV
760 770 780 790 800
SVSSSLNSGS SLGLSLGSNS TVTASTRSSV ATTSGKAPPN LPPGVPPLLP
810 820 830 840 850
NPYIMAPGLL HAYPPQVYGY DDLQMLQTRF PLDYYSIPFP TPTTPLTGRD
860 870 880 890 900
GSLASNPYSG DLTKFGRGDA SSPAPATTLA QPQQNQTQTH HTTQQTFLNP
910 920 930 940 950
ALPPGYSYTS LPYYTGVPGL PSTFQYGPAV FPVAPTSSKQ HGVNVSVNAS
960 970 980 990 1000
ATPFQQPSGY GSHGYNTGVS VTSSNTGVPD ISGSVYSKTQ QSFEKQGFHS
1010 1020 1030 1040 1050
GTPAASFNLP SALGSGGPIN PATAAAYPPA PFMHILTPHQ QPHSQILHHH
1060 1070 1080
LQQDGQTGSG QRSQTSSIPQ KPQTNKSAYN SYSWGAN
Computationally mapped potential isoform sequencesi
There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF8W726 | F8W726_HUMAN | Ubiquitin-associated protein 2-like | UBAP2L | 1,079 | Annotation score: | ||
Q5VU77 | Q5VU77_HUMAN | Ubiquitin-associated protein 2-like | UBAP2L | 350 | Annotation score: | ||
Q5VU80 | Q5VU80_HUMAN | Ubiquitin-associated protein 2-like | UBAP2L | 234 | Annotation score: | ||
Q5VU78 | Q5VU78_HUMAN | Ubiquitin-associated protein 2-like | UBAP2L | 280 | Annotation score: | ||
Q5VU79 | Q5VU79_HUMAN | Ubiquitin-associated protein 2-like | UBAP2L | 265 | Annotation score: | ||
Q5VU81 | Q5VU81_HUMAN | Ubiquitin-associated protein 2-like | UBAP2L | 182 | Annotation score: | ||
H0Y5H6 | H0Y5H6_HUMAN | Ubiquitin-associated protein 2-like | UBAP2L | 383 | Annotation score: | ||
H7C2T8 | H7C2T8_HUMAN | Ubiquitin-associated protein 2-like | UBAP2L | 399 | Annotation score: |
Sequence cautioni
The sequence CAB65100 differs from that shown. Reason: Frameshift.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 91 | P → S in BAG64560 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_026829 | 482 | Q → H. Corresponds to variant dbSNP:rs17849745Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_038235 | 143 – 150 | GASRGREF → V in isoform 4. 1 Publication | 8 | |
Alternative sequenceiVSP_019417 | 969 – 1087 | VSVTS…SWGAN → RKYPPPYKHFWTAES in isoform 2 and isoform 4. 2 PublicationsAdd BLAST | 119 | |
Alternative sequenceiVSP_042167 | 1055 | G → GQLPYLQMILCCQRQQEE in isoform 5. 1 Publication | 1 | |
Alternative sequenceiVSP_021728 | 1057 – 1087 | TGSGQ…SWGAN → DILNFVDDQLGE in isoform 3. 1 PublicationAdd BLAST | 31 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D63478 mRNA Translation: BAA09765.1 AK303533 mRNA Translation: BAG64560.1 AL590431 Genomic DNA No translation available. BC003170 mRNA Translation: AAH03170.1 AJ243668 mRNA Translation: CAB65099.1 AJ243670 mRNA Translation: CAB65101.2 AJ243669 mRNA Translation: CAB65100.2 Frameshift. |
CCDSi | CCDS1063.1 [Q14157-2] CCDS44229.1 [Q14157-1] CCDS72925.1 [Q14157-4] |
RefSeqi | NP_001120792.1, NM_001127320.2 [Q14157-1] NP_001274744.1, NM_001287815.1 [Q14157-4] NP_001274745.1, NM_001287816.1 NP_055662.3, NM_014847.3 [Q14157-2] XP_005245731.1, XM_005245674.1 XP_011508518.1, XM_011510216.1 XP_016858467.1, XM_017002978.1 XP_016858468.1, XM_017002979.1 XP_016858475.1, XM_017002986.1 XP_016858476.1, XM_017002987.1 XP_016858478.1, XM_017002989.1 XP_016858479.1, XM_017002990.1 |
Genome annotation databases
Ensembli | ENST00000343815; ENSP00000345308; ENSG00000143569 [Q14157-1] ENST00000361546; ENSP00000355343; ENSG00000143569 [Q14157-2] ENST00000428931; ENSP00000389445; ENSG00000143569 [Q14157-2] ENST00000613315; ENSP00000478447; ENSG00000143569 [Q14157-4] |
GeneIDi | 9898 |
KEGGi | hsa:9898 |
UCSCi | uc001fep.5, human [Q14157-2] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D63478 mRNA Translation: BAA09765.1 AK303533 mRNA Translation: BAG64560.1 AL590431 Genomic DNA No translation available. BC003170 mRNA Translation: AAH03170.1 AJ243668 mRNA Translation: CAB65099.1 AJ243670 mRNA Translation: CAB65101.2 AJ243669 mRNA Translation: CAB65100.2 Frameshift. |
CCDSi | CCDS1063.1 [Q14157-2] CCDS44229.1 [Q14157-1] CCDS72925.1 [Q14157-4] |
RefSeqi | NP_001120792.1, NM_001127320.2 [Q14157-1] NP_001274744.1, NM_001287815.1 [Q14157-4] NP_001274745.1, NM_001287816.1 NP_055662.3, NM_014847.3 [Q14157-2] XP_005245731.1, XM_005245674.1 XP_011508518.1, XM_011510216.1 XP_016858467.1, XM_017002978.1 XP_016858468.1, XM_017002979.1 XP_016858475.1, XM_017002986.1 XP_016858476.1, XM_017002987.1 XP_016858478.1, XM_017002989.1 XP_016858479.1, XM_017002990.1 |
3D structure databases
SMRi | Q14157 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 115227, 199 interactors |
CORUMi | Q14157 |
IntActi | Q14157, 34 interactors |
MINTi | Q14157 |
STRINGi | 9606.ENSP00000389445 |
Chemistry databases
ChEMBLi | CHEMBL4295819 |
PTM databases
GlyConnecti | 2895, 1 O-Linked glycan (2 sites) |
GlyGeni | Q14157, 11 sites, 1 O-linked glycan (9 sites) |
iPTMneti | Q14157 |
MetOSitei | Q14157 |
PhosphoSitePlusi | Q14157 |
Genetic variation databases
BioMutai | UBAP2L |
DMDMi | 109940042 |
Proteomic databases
CPTACi | CPTAC-599 CPTAC-600 |
EPDi | Q14157 |
jPOSTi | Q14157 |
MassIVEi | Q14157 |
PaxDbi | Q14157 |
PeptideAtlasi | Q14157 |
PRIDEi | Q14157 |
ProteomicsDBi | 59867 [Q14157-2] 59868 [Q14157-1] 59869 [Q14157-3] 59870 [Q14157-4] 59871 [Q14157-5] |
Protocols and materials databases
Antibodypediai | 34148, 184 antibodies |
Genome annotation databases
Ensembli | ENST00000343815; ENSP00000345308; ENSG00000143569 [Q14157-1] ENST00000361546; ENSP00000355343; ENSG00000143569 [Q14157-2] ENST00000428931; ENSP00000389445; ENSG00000143569 [Q14157-2] ENST00000613315; ENSP00000478447; ENSG00000143569 [Q14157-4] |
GeneIDi | 9898 |
KEGGi | hsa:9898 |
UCSCi | uc001fep.5, human [Q14157-2] |
Organism-specific databases
CTDi | 9898 |
DisGeNETi | 9898 |
GeneCardsi | UBAP2L |
HGNCi | HGNC:29877, UBAP2L |
HPAi | ENSG00000143569, Low tissue specificity |
MIMi | 616472, gene |
neXtProti | NX_Q14157 |
OpenTargetsi | ENSG00000143569 |
PharmGKBi | PA134883839 |
VEuPathDBi | HostDB:ENSG00000143569.18 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QPRH, Eukaryota |
GeneTreei | ENSGT00390000003453 |
HOGENOMi | CLU_009850_0_0_1 |
InParanoidi | Q14157 |
OMAi | VKTEWEV |
OrthoDBi | 234795at2759 |
PhylomeDBi | Q14157 |
TreeFami | TF328468 |
Enzyme and pathway databases
PathwayCommonsi | Q14157 |
SIGNORi | Q14157 |
Miscellaneous databases
BioGRID-ORCSi | 9898, 73 hits in 1008 CRISPR screens |
ChiTaRSi | UBAP2L, human |
GeneWikii | UBAP2L |
GenomeRNAii | 9898 |
Pharosi | Q14157, Tbio |
PROi | PR:Q14157 |
RNActi | Q14157, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000143569, Expressed in left lobe of thyroid gland and 241 other tissues |
ExpressionAtlasi | Q14157, baseline and differential |
Genevisiblei | Q14157, HS |
Family and domain databases
InterProi | View protein in InterPro IPR015940, UBA IPR009060, UBA-like_sf IPR022166, UBAP2/Lig |
Pfami | View protein in Pfam PF12478, DUF3697, 1 hit |
SMARTi | View protein in SMART SM00165, UBA, 1 hit |
SUPFAMi | SSF46934, SSF46934, 1 hit |
PROSITEi | View protein in PROSITE PS50030, UBA, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | UBP2L_HUMAN | |
Accessioni | Q14157Primary (citable) accession number: Q14157 Secondary accession number(s): B4E0U8 Q9UGL5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | June 27, 2006 | |
Last modified: | April 7, 2021 | |
This is version 181 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot