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Protein

Rho guanine nucleotide exchange factor 7

Gene

ARHGEF7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling. Functions in cell migration, attachment and cell spreading. Promotes targeting of RAC1 to focal adhesions (By similarity). May function as a positive regulator of apoptosis. Downstream of NMDA receptors and CaMKK-CaMK1 signaling cascade, promotes the formation of spines and synapses in hippocampal neurons.By similarity3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • guanyl-nucleotide exchange factor activity Source: BHF-UCL
  • protein kinase binding Source: BHF-UCL
  • Rho guanyl-nucleotide exchange factor activity Source: Reactome

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGuanine-nucleotide releasing factor
Biological processNeurogenesis

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-182971 EGFR downregulation
R-HSA-193648 NRAGE signals death through JNK
R-HSA-194840 Rho GTPase cycle
R-HSA-3928664 Ephrin signaling
R-HSA-416482 G alpha (12/13) signalling events

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q14155

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q14155

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Rho guanine nucleotide exchange factor 7
Alternative name(s):
Beta-Pix
COOL-1
PAK-interacting exchange factor beta
p85
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ARHGEF7
Synonyms:COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
ORF Names:Nbla10314
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 13

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000102606.17

Human Gene Nomenclature Database

More...
HGNCi
HGNC:15607 ARHGEF7

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
605477 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q14155

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell projection, Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
8874

Open Targets

More...
OpenTargetsi
ENSG00000102606

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA24977

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ARHGEF7

Domain mapping of disease mutations (DMDM)

More...
DMDMi
50403776

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000809211 – 803Rho guanine nucleotide exchange factor 7Add BLAST803
Isoform 1 (identifier: Q14155-1)
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
Isoform 6 (identifier: Q14155-6)
Initiator methionineiRemovedCombined sources

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei153PhosphoserineBy similarity1
Modified residuei176PhosphoserineBy similarity1
Modified residuei249PhosphoserineCombined sources1
Modified residuei257PhosphoserineCombined sources1
Modified residuei518PhosphoserineCombined sources1
Modified residuei694Phosphoserine; by CaMK1Combined sources1 Publication1
Isoform 1 (identifier: Q14155-1)
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei2N-acetylthreonineCombined sources1
Modified residuei560PhosphoserineCombined sources1
Modified residuei579PhosphoserineCombined sources1
Isoform 6 (identifier: Q14155-6)
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei2N-acetylthreonineCombined sources1
Isoform 5 (identifier: Q14155-5)
Modified residuei645PhosphoserineCombined sources1
Modified residuei664PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by PTK2/FAK1; this promotes interaction with RAC1 (By similarity). Phosphorylated on Ser-694 by CaMK1; enhancement of GEF activity and downstream activation of RAC1.By similarity1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q14155

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q14155

PeptideAtlas

More...
PeptideAtlasi
Q14155

PRoteomics IDEntifications database

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PRIDEi
Q14155

ProteomicsDB human proteome resource

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ProteomicsDBi
59858
59859 [Q14155-1]
59860 [Q14155-2]
59861 [Q14155-3]
59862 [Q14155-5]
59863 [Q14155-6]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q14155

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q14155

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000102606 Expressed in 224 organ(s), highest expression level in corpus callosum

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q14155 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q14155 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA004744

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with PAK kinases through the SH3 domain. Interacts with GIT1 and TGFB1I1. Interacts with PTK2/FAK1 and RAC1. Interacts with ITCH and PARVB (By similarity). Interacts with unphosphorylated PAK1. Interacts with SCRIB; interaction is direct and may play a role in regulation of apoptosis. Interacts with FRMPD4 (via N-terminus). Interacts with CaMK1. Interacts with BIN2. Isoform 1 and isoform 5 interact with SNX27.By similarity6 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
114393, 50 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q14155

Database of interacting proteins

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DIPi
DIP-40794N

Protein interaction database and analysis system

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IntActi
Q14155, 27 interactors

Molecular INTeraction database

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MINTi
Q14155

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000364893

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1803
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q14155

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q14155

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q14155

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 133Calponin-homology (CH)PROSITE-ProRule annotationAdd BLAST133
Domaini184 – 243SH3PROSITE-ProRule annotationAdd BLAST60
Domaini271 – 451DHPROSITE-ProRule annotationAdd BLAST181
Domaini473 – 578PHPROSITE-ProRule annotationAdd BLAST106

Keywords - Domaini

SH3 domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2070 Eukaryota
ENOG410XNNP LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155360

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG050569

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q14155

KEGG Orthology (KO)

More...
KOi
K13710

Database of Orthologous Groups

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OrthoDBi
EOG091G04XA

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q14155

TreeFam database of animal gene trees

More...
TreeFami
TF316105

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00160 RhoGEF, 1 hit
cd12061 SH3_betaPIX, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.418.10, 1 hit
1.20.900.10, 1 hit
2.30.29.30, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR035789 BetaPIX_SH3
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR001331 GDS_CDC24_CS
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00307 CH, 1 hit
PF00169 PH, 1 hit
PF00621 RhoGEF, 1 hit
PF07653 SH3_2, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00452 SH3DOMAIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00033 CH, 1 hit
SM00233 PH, 1 hit
SM00325 RhoGEF, 1 hit
SM00326 SH3, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47576 SSF47576, 1 hit
SSF48065 SSF48065, 1 hit
SSF50044 SSF50044, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50021 CH, 1 hit
PS00741 DH_1, 1 hit
PS50010 DH_2, 1 hit
PS50003 PH_DOMAIN, 1 hit
PS50002 SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 6 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 10 potential isoforms that are computationally mapped.Show allAlign All

Isoform 4 (identifier: Q14155-4) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNSAEQTVTW LITLGVLESP KKTISDPEGF LQASLKDGVV LCRLLERLLP
60 70 80 90 100
GTIEKVYPEP RSESECLSNI REFLRGCGAS LRLELLFPPS QPPQHLVTTI
110 120 130 140 150
LLSASTFDAN DLYQGQNFNK VLSSLVTLNK VTADIGLGSD SVCARPSSHR
160 170 180 190 200
IKSFDSLGSQ SLHTRTSKLF QGQYRSLDMT DNSNNQLVVR AKFNFQQTNE
210 220 230 240 250
DELSFSKGDV IHVTRVEEGG WWEGTLNGRT GWFPSNYVRE VKASEKPVSP
260 270 280 290 300
KSGTLKSPPK GFDTTAINKS YYNVVLQNIL ETENEYSKEL QTVLSTYLRP
310 320 330 340 350
LQTSEKLSSA NISYLMGNLE EICSFQQMLV QSLEECTKLP EAQQRVGGCF
360 370 380 390 400
LNLMPQMKTL YLTYCANHPS AVNVLTEHSE ELGEFMETKG ASSPGILVLT
410 420 430 440 450
TGLSKPFMRL DKYPTLLKEL ERHMEDYHTD RQDIQKSMAA FKNLSAQCQE
460 470 480 490 500
VRKRKELELQ ILTEAIRNWE GDDIKTLGNV TYMSQVLIQC AGSEEKNERY
510 520 530 540 550
LLLFPNVLLM LSASPRMSGF IYQGKLPTTG MTITKLEDSE NHRNAFEISG
560 570 580 590 600
SMIERILVSC NNQQDLQEWV EHLQKQTKVT SVGNPTIKPH SVPSHTLPSH
610 620 630 640 650
PVTPSSKHAD SKPAPLTPAY HTLPHPSHHG TPHTTINWGP LEPPKTPKPW
660 670 680 690 700
SLSCLRPAPP LRPSAALCYK EDLSKSPKTM KKLLPKRKPE RKPSDEEFAS
710 720 730 740 750
RKSTAALEED AQILKVIEAY CTSAKTRQTL NSTWQGTDLM HNHVLADDDQ
760 770 780 790 800
PSLDSLGRRS SLSRLEPSDL SEDSDYDSIW TAHSYRMGST SRKSCCSYIS

HQN
Length:803
Mass (Da):90,012
Last modified:July 19, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i613EBA839E6FDBFD
GO
Isoform 1 (identifier: Q14155-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-178: Missing.
     733-803: TWQGTDLMHN...SCCSYISHQN → SSRKESAPQV...NDPAWDETNL

Show »
Length:646
Mass (Da):73,140
Checksum:iB5B5A83F0EBC28D2
GO
Isoform 2 (identifier: Q14155-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     56-105: Missing.

Show »
Length:753
Mass (Da):84,477
Checksum:i04178E64ACF43846
GO
Isoform 3 (identifier: Q14155-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     85-105: Missing.

Show »
Length:782
Mass (Da):87,770
Checksum:i9C602026D90A6D01
GO
Isoform 5 (identifier: Q14155-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     85-177: Missing.
     733-803: TWQGTDLMHN...SCCSYISHQN → SSRKESAPQV...NDPAWDETNL

Show »
Length:731
Mass (Da):82,571
Checksum:iE82D55E6187DADB2
GO
Isoform 6 (identifier: Q14155-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-178: Missing.

Show »
Length:625
Mass (Da):70,450
Checksum:i25DAD75DD4B0AC2E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B1ALK7B1ALK7_HUMAN
Rho guanine nucleotide exchange fac...
ARHGEF7
705Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PDQ5E9PDQ5_HUMAN
Rho guanine nucleotide exchange fac...
ARHGEF7
547Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EUY6E7EUY6_HUMAN
Rho guanine nucleotide exchange fac...
ARHGEF7
447Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8YG42A0A2R8YG42_HUMAN
Rho guanine nucleotide exchange fac...
ARHGEF7
862Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7ENL8E7ENL8_HUMAN
Rho guanine nucleotide exchange fac...
ARHGEF7
143Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B1ANY6B1ANY6_HUMAN
Rho guanine nucleotide exchange fac...
ARHGEF7
66Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EU80E7EU80_HUMAN
Rho guanine nucleotide exchange fac...
ARHGEF7
151Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JDI6C9JDI6_HUMAN
Rho guanine nucleotide exchange fac...
ARHGEF7
61Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JAD7C9JAD7_HUMAN
Rho guanine nucleotide exchange fac...
ARHGEF7
39Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6SJA5F6SJA5_HUMAN
Rho guanine nucleotide exchange fac...
ARHGEF7
130Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH50521 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAA09763 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAD38906 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti52 – 55TIEK → EEKR in BAD66827 (PubMed:15491607).Curated4
Sequence conflicti343Q → K in AAH33905 (PubMed:15489334).Curated1
Sequence conflicti552M → V in AAH33905 (PubMed:15489334).Curated1
Sequence conflicti595H → D in BAD66827 (PubMed:15491607).Curated1
Sequence conflicti636I → T in AAH50521 (PubMed:15489334).Curated1
Sequence conflicti740M → L in AAH33905 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_064694790T → A Found in a clear cell renal carcinoma case; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0110321 – 178Missing in isoform 1 and isoform 6. 3 PublicationsAdd BLAST178
Alternative sequenceiVSP_01103356 – 105Missing in isoform 2. 1 PublicationAdd BLAST50
Alternative sequenceiVSP_03463985 – 177Missing in isoform 5. 1 PublicationAdd BLAST93
Alternative sequenceiVSP_01103485 – 105Missing in isoform 3. 1 PublicationAdd BLAST21
Alternative sequenceiVSP_011035733 – 803TWQGT…ISHQN → SSRKESAPQVLLPEEEKIIV EETKSNGQTVIEEKSLVDTV YALKDEVQELRQDNKKMKKS LEEEQRARKDLEKLVRKVLK NMNDPAWDETNL in isoform 1 and isoform 5. 4 PublicationsAdd BLAST71

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
D63476 mRNA Translation: BAA09763.2 Different initiation.
AL834228 mRNA Translation: CAD38906.1 Different initiation.
AL139086 Genomic DNA No translation available.
AL390754 Genomic DNA No translation available.
CH471085 Genomic DNA Translation: EAX09143.1
BC033905 mRNA Translation: AAH33905.1
BC050521 mRNA Translation: AAH50521.1 Different initiation.
BC060776 mRNA Translation: AAH60776.1
AB177849 mRNA Translation: BAD66827.1
AB075521 mRNA Translation: BAE45764.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS32009.1 [Q14155-3]
CCDS45068.1 [Q14155-4]
CCDS45069.1 [Q14155-2]
CCDS86362.1 [Q14155-6]
CCDS9521.1 [Q14155-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001106983.1, NM_001113511.2 [Q14155-4]
NP_001106984.1, NM_001113512.2 [Q14155-2]
NP_001106985.1, NM_001113513.1 [Q14155-1]
NP_001307780.1, NM_001320851.1 [Q14155-1]
NP_001307782.1, NM_001320853.1
NP_001307783.1, NM_001320854.1
NP_001317526.1, NM_001330597.1 [Q14155-6]
NP_001317527.1, NM_001330598.1 [Q14155-6]
NP_003890.1, NM_003899.3 [Q14155-1]
NP_663788.1, NM_145735.3 [Q14155-3]
XP_016876313.1, XM_017020824.1
XP_016876314.1, XM_017020825.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.508738

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000317133; ENSP00000325994; ENSG00000102606 [Q14155-3]
ENST00000375723; ENSP00000364875; ENSG00000102606 [Q14155-6]
ENST00000375736; ENSP00000364888; ENSG00000102606 [Q14155-1]
ENST00000375739; ENSP00000364891; ENSG00000102606 [Q14155-2]
ENST00000375741; ENSP00000364893; ENSG00000102606 [Q14155-4]
ENST00000426073; ENSP00000397068; ENSG00000102606 [Q14155-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
8874

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:8874

UCSC genome browser

More...
UCSCi
uc001vrr.3 human [Q14155-4]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D63476 mRNA Translation: BAA09763.2 Different initiation.
AL834228 mRNA Translation: CAD38906.1 Different initiation.
AL139086 Genomic DNA No translation available.
AL390754 Genomic DNA No translation available.
CH471085 Genomic DNA Translation: EAX09143.1
BC033905 mRNA Translation: AAH33905.1
BC050521 mRNA Translation: AAH50521.1 Different initiation.
BC060776 mRNA Translation: AAH60776.1
AB177849 mRNA Translation: BAD66827.1
AB075521 mRNA Translation: BAE45764.1
CCDSiCCDS32009.1 [Q14155-3]
CCDS45068.1 [Q14155-4]
CCDS45069.1 [Q14155-2]
CCDS86362.1 [Q14155-6]
CCDS9521.1 [Q14155-1]
RefSeqiNP_001106983.1, NM_001113511.2 [Q14155-4]
NP_001106984.1, NM_001113512.2 [Q14155-2]
NP_001106985.1, NM_001113513.1 [Q14155-1]
NP_001307780.1, NM_001320851.1 [Q14155-1]
NP_001307782.1, NM_001320853.1
NP_001307783.1, NM_001320854.1
NP_001317526.1, NM_001330597.1 [Q14155-6]
NP_001317527.1, NM_001330598.1 [Q14155-6]
NP_003890.1, NM_003899.3 [Q14155-1]
NP_663788.1, NM_145735.3 [Q14155-3]
XP_016876313.1, XM_017020824.1
XP_016876314.1, XM_017020825.1
UniGeneiHs.508738

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BY1NMR-A260-467[»]
1ZSGNMR-A179-243[»]
2L3GNMR-A1-137[»]
5SXPX-ray1.65A/B/C/D183-243[»]
ProteinModelPortaliQ14155
SMRiQ14155
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114393, 50 interactors
CORUMiQ14155
DIPiDIP-40794N
IntActiQ14155, 27 interactors
MINTiQ14155
STRINGi9606.ENSP00000364893

PTM databases

iPTMnetiQ14155
PhosphoSitePlusiQ14155

Polymorphism and mutation databases

BioMutaiARHGEF7
DMDMi50403776

Proteomic databases

EPDiQ14155
PaxDbiQ14155
PeptideAtlasiQ14155
PRIDEiQ14155
ProteomicsDBi59858
59859 [Q14155-1]
59860 [Q14155-2]
59861 [Q14155-3]
59862 [Q14155-5]
59863 [Q14155-6]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
8874
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000317133; ENSP00000325994; ENSG00000102606 [Q14155-3]
ENST00000375723; ENSP00000364875; ENSG00000102606 [Q14155-6]
ENST00000375736; ENSP00000364888; ENSG00000102606 [Q14155-1]
ENST00000375739; ENSP00000364891; ENSG00000102606 [Q14155-2]
ENST00000375741; ENSP00000364893; ENSG00000102606 [Q14155-4]
ENST00000426073; ENSP00000397068; ENSG00000102606 [Q14155-1]
GeneIDi8874
KEGGihsa:8874
UCSCiuc001vrr.3 human [Q14155-4]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
8874
DisGeNETi8874
EuPathDBiHostDB:ENSG00000102606.17

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ARHGEF7

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0037536
HGNCiHGNC:15607 ARHGEF7
HPAiHPA004744
MIMi605477 gene
neXtProtiNX_Q14155
OpenTargetsiENSG00000102606
PharmGKBiPA24977

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2070 Eukaryota
ENOG410XNNP LUCA
GeneTreeiENSGT00940000155360
HOVERGENiHBG050569
InParanoidiQ14155
KOiK13710
OrthoDBiEOG091G04XA
PhylomeDBiQ14155
TreeFamiTF316105

Enzyme and pathway databases

ReactomeiR-HSA-182971 EGFR downregulation
R-HSA-193648 NRAGE signals death through JNK
R-HSA-194840 Rho GTPase cycle
R-HSA-3928664 Ephrin signaling
R-HSA-416482 G alpha (12/13) signalling events
SignaLinkiQ14155
SIGNORiQ14155

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ARHGEF7 human
EvolutionaryTraceiQ14155

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
ARHGEF7

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
8874

Protein Ontology

More...
PROi
PR:Q14155

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000102606 Expressed in 224 organ(s), highest expression level in corpus callosum
ExpressionAtlasiQ14155 baseline and differential
GenevisibleiQ14155 HS

Family and domain databases

CDDicd00160 RhoGEF, 1 hit
cd12061 SH3_betaPIX, 1 hit
Gene3Di1.10.418.10, 1 hit
1.20.900.10, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR035789 BetaPIX_SH3
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR001331 GDS_CDC24_CS
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PfamiView protein in Pfam
PF00307 CH, 1 hit
PF00169 PH, 1 hit
PF00621 RhoGEF, 1 hit
PF07653 SH3_2, 1 hit
PRINTSiPR00452 SH3DOMAIN
SMARTiView protein in SMART
SM00033 CH, 1 hit
SM00233 PH, 1 hit
SM00325 RhoGEF, 1 hit
SM00326 SH3, 1 hit
SUPFAMiSSF47576 SSF47576, 1 hit
SSF48065 SSF48065, 1 hit
SSF50044 SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS50021 CH, 1 hit
PS00741 DH_1, 1 hit
PS50010 DH_2, 1 hit
PS50003 PH_DOMAIN, 1 hit
PS50002 SH3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiARHG7_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q14155
Secondary accession number(s): B1ALK6
, B1ALK8, Q3LIA4, Q5W9H0, Q6P9G3, Q6PII2, Q86W63, Q8N3M1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 19, 2004
Last modified: December 5, 2018
This is version 205 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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