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Protein

Rho guanine nucleotide exchange factor 7

Gene

ARHGEF7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling. Functions in cell migration, attachment and cell spreading. Promotes targeting of RAC1 to focal adhesions (By similarity). May function as a positive regulator of apoptosis. Downstream of NMDA receptors and CaMKK-CaMK1 signaling cascade, promotes the formation of spines and synapses in hippocampal neurons.By similarity3 Publications

GO - Molecular functioni

  • guanyl-nucleotide exchange factor activity Source: BHF-UCL
  • protein kinase binding Source: BHF-UCL
  • Rho guanyl-nucleotide exchange factor activity Source: Reactome

GO - Biological processi

Keywordsi

Molecular functionGuanine-nucleotide releasing factor
Biological processNeurogenesis

Enzyme and pathway databases

ReactomeiR-HSA-182971 EGFR downregulation
R-HSA-193648 NRAGE signals death through JNK
R-HSA-194840 Rho GTPase cycle
R-HSA-3928664 Ephrin signaling
R-HSA-416482 G alpha (12/13) signalling events
SignaLinkiQ14155
SIGNORiQ14155

Names & Taxonomyi

Protein namesi
Recommended name:
Rho guanine nucleotide exchange factor 7
Alternative name(s):
Beta-Pix
COOL-1
PAK-interacting exchange factor beta
p85
Gene namesi
Name:ARHGEF7
Synonyms:COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
ORF Names:Nbla10314
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

EuPathDBiHostDB:ENSG00000102606.17
HGNCiHGNC:15607 ARHGEF7
MIMi605477 gene
neXtProtiNX_Q14155

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell projection, Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi8874
OpenTargetsiENSG00000102606
PharmGKBiPA24977

Polymorphism and mutation databases

BioMutaiARHGEF7
DMDMi50403776

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000809211 – 803Rho guanine nucleotide exchange factor 7Add BLAST803
Isoform 1 (identifier: Q14155-1)
Initiator methionineiRemovedCombined sources
Isoform 6 (identifier: Q14155-6)
Initiator methionineiRemovedCombined sources

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei153PhosphoserineBy similarity1
Modified residuei176PhosphoserineBy similarity1
Modified residuei249PhosphoserineCombined sources1
Modified residuei257PhosphoserineCombined sources1
Modified residuei518PhosphoserineCombined sources1
Modified residuei694Phosphoserine; by CaMK1Combined sources1 Publication1
Isoform 1 (identifier: Q14155-1)
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei2N-acetylthreonineCombined sources1
Modified residuei560PhosphoserineCombined sources1
Modified residuei579PhosphoserineCombined sources1
Isoform 6 (identifier: Q14155-6)
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei2N-acetylthreonineCombined sources1
Isoform 5 (identifier: Q14155-5)
Modified residuei645PhosphoserineCombined sources1
Modified residuei664PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated by PTK2/FAK1; this promotes interaction with RAC1 (By similarity). Phosphorylated on Ser-694 by CaMK1; enhancement of GEF activity and downstream activation of RAC1.By similarity1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ14155
PaxDbiQ14155
PeptideAtlasiQ14155
PRIDEiQ14155
ProteomicsDBi59858
59859 [Q14155-1]
59860 [Q14155-2]
59861 [Q14155-3]
59862 [Q14155-5]
59863 [Q14155-6]

PTM databases

iPTMnetiQ14155
PhosphoSitePlusiQ14155

Expressioni

Gene expression databases

BgeeiENSG00000102606 Expressed in 224 organ(s), highest expression level in corpus callosum
ExpressionAtlasiQ14155 baseline and differential
GenevisibleiQ14155 HS

Organism-specific databases

HPAiHPA004744

Interactioni

Subunit structurei

Interacts with PAK kinases through the SH3 domain. Interacts with GIT1 and TGFB1I1. Interacts with PTK2/FAK1 and RAC1. Interacts with ITCH and PARVB (By similarity). Interacts with unphosphorylated PAK1. Interacts with SCRIB; interaction is direct and may play a role in regulation of apoptosis. Interacts with FRMPD4 (via N-terminus). Interacts with CaMK1. Interacts with BIN2. Isoform 1 and isoform 5 interact with SNX27.By similarity6 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi114393, 50 interactors
CORUMiQ14155
DIPiDIP-40794N
IntActiQ14155, 27 interactors
MINTiQ14155
STRINGi9606.ENSP00000364893

Structurei

Secondary structure

1803
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ14155
SMRiQ14155
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ14155

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 133Calponin-homology (CH)PROSITE-ProRule annotationAdd BLAST133
Domaini184 – 243SH3PROSITE-ProRule annotationAdd BLAST60
Domaini271 – 451DHPROSITE-ProRule annotationAdd BLAST181
Domaini473 – 578PHPROSITE-ProRule annotationAdd BLAST106

Keywords - Domaini

SH3 domain

Phylogenomic databases

eggNOGiKOG2070 Eukaryota
ENOG410XNNP LUCA
GeneTreeiENSGT00930000150955
HOVERGENiHBG050569
InParanoidiQ14155
KOiK13710
OrthoDBiEOG091G04XA
PhylomeDBiQ14155
TreeFamiTF316105

Family and domain databases

CDDicd00160 RhoGEF, 1 hit
cd12061 SH3_betaPIX, 1 hit
Gene3Di1.10.418.10, 1 hit
1.20.900.10, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR035789 BetaPIX_SH3
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR001331 GDS_CDC24_CS
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PfamiView protein in Pfam
PF00307 CH, 1 hit
PF00169 PH, 1 hit
PF00621 RhoGEF, 1 hit
PF07653 SH3_2, 1 hit
PRINTSiPR00452 SH3DOMAIN
SMARTiView protein in SMART
SM00033 CH, 1 hit
SM00233 PH, 1 hit
SM00325 RhoGEF, 1 hit
SM00326 SH3, 1 hit
SUPFAMiSSF47576 SSF47576, 1 hit
SSF48065 SSF48065, 1 hit
SSF50044 SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS50021 CH, 1 hit
PS00741 DH_1, 1 hit
PS50010 DH_2, 1 hit
PS50003 PH_DOMAIN, 1 hit
PS50002 SH3, 1 hit

Sequences (6+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 10 potential isoforms that are computationally mapped.Show allAlign All

Isoform 4 (identifier: Q14155-4) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNSAEQTVTW LITLGVLESP KKTISDPEGF LQASLKDGVV LCRLLERLLP
60 70 80 90 100
GTIEKVYPEP RSESECLSNI REFLRGCGAS LRLELLFPPS QPPQHLVTTI
110 120 130 140 150
LLSASTFDAN DLYQGQNFNK VLSSLVTLNK VTADIGLGSD SVCARPSSHR
160 170 180 190 200
IKSFDSLGSQ SLHTRTSKLF QGQYRSLDMT DNSNNQLVVR AKFNFQQTNE
210 220 230 240 250
DELSFSKGDV IHVTRVEEGG WWEGTLNGRT GWFPSNYVRE VKASEKPVSP
260 270 280 290 300
KSGTLKSPPK GFDTTAINKS YYNVVLQNIL ETENEYSKEL QTVLSTYLRP
310 320 330 340 350
LQTSEKLSSA NISYLMGNLE EICSFQQMLV QSLEECTKLP EAQQRVGGCF
360 370 380 390 400
LNLMPQMKTL YLTYCANHPS AVNVLTEHSE ELGEFMETKG ASSPGILVLT
410 420 430 440 450
TGLSKPFMRL DKYPTLLKEL ERHMEDYHTD RQDIQKSMAA FKNLSAQCQE
460 470 480 490 500
VRKRKELELQ ILTEAIRNWE GDDIKTLGNV TYMSQVLIQC AGSEEKNERY
510 520 530 540 550
LLLFPNVLLM LSASPRMSGF IYQGKLPTTG MTITKLEDSE NHRNAFEISG
560 570 580 590 600
SMIERILVSC NNQQDLQEWV EHLQKQTKVT SVGNPTIKPH SVPSHTLPSH
610 620 630 640 650
PVTPSSKHAD SKPAPLTPAY HTLPHPSHHG TPHTTINWGP LEPPKTPKPW
660 670 680 690 700
SLSCLRPAPP LRPSAALCYK EDLSKSPKTM KKLLPKRKPE RKPSDEEFAS
710 720 730 740 750
RKSTAALEED AQILKVIEAY CTSAKTRQTL NSTWQGTDLM HNHVLADDDQ
760 770 780 790 800
PSLDSLGRRS SLSRLEPSDL SEDSDYDSIW TAHSYRMGST SRKSCCSYIS

HQN
Length:803
Mass (Da):90,012
Last modified:July 19, 2004 - v2
Checksum:i613EBA839E6FDBFD
GO
Isoform 1 (identifier: Q14155-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-178: Missing.
     733-803: TWQGTDLMHN...SCCSYISHQN → SSRKESAPQV...NDPAWDETNL

Show »
Length:646
Mass (Da):73,140
Checksum:iB5B5A83F0EBC28D2
GO
Isoform 2 (identifier: Q14155-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     56-105: Missing.

Show »
Length:753
Mass (Da):84,477
Checksum:i04178E64ACF43846
GO
Isoform 3 (identifier: Q14155-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     85-105: Missing.

Show »
Length:782
Mass (Da):87,770
Checksum:i9C602026D90A6D01
GO
Isoform 5 (identifier: Q14155-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     85-177: Missing.
     733-803: TWQGTDLMHN...SCCSYISHQN → SSRKESAPQV...NDPAWDETNL

Show »
Length:731
Mass (Da):82,571
Checksum:iE82D55E6187DADB2
GO
Isoform 6 (identifier: Q14155-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-178: Missing.

Show »
Length:625
Mass (Da):70,450
Checksum:i25DAD75DD4B0AC2E
GO

Computationally mapped potential isoform sequencesi

There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B1ALK7B1ALK7_HUMAN
Rho guanine nucleotide exchange fac...
ARHGEF7
705Annotation score:
E9PDQ5E9PDQ5_HUMAN
Rho guanine nucleotide exchange fac...
ARHGEF7
547Annotation score:
E7EUY6E7EUY6_HUMAN
Rho guanine nucleotide exchange fac...
ARHGEF7
447Annotation score:
A0A2R8YG42A0A2R8YG42_HUMAN
Rho guanine nucleotide exchange fac...
ARHGEF7
862Annotation score:
E7ENL8E7ENL8_HUMAN
Rho guanine nucleotide exchange fac...
ARHGEF7
143Annotation score:
E7EU80E7EU80_HUMAN
Rho guanine nucleotide exchange fac...
ARHGEF7
151Annotation score:
B1ANY6B1ANY6_HUMAN
Rho guanine nucleotide exchange fac...
ARHGEF7
66Annotation score:
C9JDI6C9JDI6_HUMAN
Rho guanine nucleotide exchange fac...
ARHGEF7
61Annotation score:
F6SJA5F6SJA5_HUMAN
Rho guanine nucleotide exchange fac...
ARHGEF7
130Annotation score:
C9JAD7C9JAD7_HUMAN
Rho guanine nucleotide exchange fac...
ARHGEF7
39Annotation score:

Sequence cautioni

The sequence AAH50521 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAA09763 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAD38906 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti52 – 55TIEK → EEKR in BAD66827 (PubMed:15491607).Curated4
Sequence conflicti343Q → K in AAH33905 (PubMed:15489334).Curated1
Sequence conflicti552M → V in AAH33905 (PubMed:15489334).Curated1
Sequence conflicti595H → D in BAD66827 (PubMed:15491607).Curated1
Sequence conflicti636I → T in AAH50521 (PubMed:15489334).Curated1
Sequence conflicti740M → L in AAH33905 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_064694790T → A Found in a clear cell renal carcinoma case; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0110321 – 178Missing in isoform 1 and isoform 6. 3 PublicationsAdd BLAST178
Alternative sequenceiVSP_01103356 – 105Missing in isoform 2. 1 PublicationAdd BLAST50
Alternative sequenceiVSP_03463985 – 177Missing in isoform 5. 1 PublicationAdd BLAST93
Alternative sequenceiVSP_01103485 – 105Missing in isoform 3. 1 PublicationAdd BLAST21
Alternative sequenceiVSP_011035733 – 803TWQGT…ISHQN → SSRKESAPQVLLPEEEKIIV EETKSNGQTVIEEKSLVDTV YALKDEVQELRQDNKKMKKS LEEEQRARKDLEKLVRKVLK NMNDPAWDETNL in isoform 1 and isoform 5. 4 PublicationsAdd BLAST71

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D63476 mRNA Translation: BAA09763.2 Different initiation.
AL834228 mRNA Translation: CAD38906.1 Different initiation.
AL139086 Genomic DNA No translation available.
AL390754 Genomic DNA No translation available.
CH471085 Genomic DNA Translation: EAX09143.1
BC033905 mRNA Translation: AAH33905.1
BC050521 mRNA Translation: AAH50521.1 Different initiation.
BC060776 mRNA Translation: AAH60776.1
AB177849 mRNA Translation: BAD66827.1
AB075521 mRNA Translation: BAE45764.1
CCDSiCCDS32009.1 [Q14155-3]
CCDS45068.1 [Q14155-4]
CCDS45069.1 [Q14155-2]
CCDS86362.1 [Q14155-6]
CCDS9521.1 [Q14155-1]
RefSeqiNP_001106983.1, NM_001113511.2 [Q14155-4]
NP_001106984.1, NM_001113512.2 [Q14155-2]
NP_001106985.1, NM_001113513.1 [Q14155-1]
NP_001307780.1, NM_001320851.1 [Q14155-1]
NP_001307782.1, NM_001320853.1
NP_001307783.1, NM_001320854.1
NP_001317526.1, NM_001330597.1 [Q14155-6]
NP_001317527.1, NM_001330598.1 [Q14155-6]
NP_003890.1, NM_003899.3 [Q14155-1]
NP_663788.1, NM_145735.3 [Q14155-3]
XP_016876313.1, XM_017020824.1
XP_016876314.1, XM_017020825.1
UniGeneiHs.508738

Genome annotation databases

EnsembliENST00000317133; ENSP00000325994; ENSG00000102606 [Q14155-3]
ENST00000375723; ENSP00000364875; ENSG00000102606 [Q14155-6]
ENST00000375736; ENSP00000364888; ENSG00000102606 [Q14155-1]
ENST00000375739; ENSP00000364891; ENSG00000102606 [Q14155-2]
ENST00000375741; ENSP00000364893; ENSG00000102606 [Q14155-4]
ENST00000426073; ENSP00000397068; ENSG00000102606 [Q14155-1]
GeneIDi8874
KEGGihsa:8874
UCSCiuc001vrr.3 human [Q14155-4]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D63476 mRNA Translation: BAA09763.2 Different initiation.
AL834228 mRNA Translation: CAD38906.1 Different initiation.
AL139086 Genomic DNA No translation available.
AL390754 Genomic DNA No translation available.
CH471085 Genomic DNA Translation: EAX09143.1
BC033905 mRNA Translation: AAH33905.1
BC050521 mRNA Translation: AAH50521.1 Different initiation.
BC060776 mRNA Translation: AAH60776.1
AB177849 mRNA Translation: BAD66827.1
AB075521 mRNA Translation: BAE45764.1
CCDSiCCDS32009.1 [Q14155-3]
CCDS45068.1 [Q14155-4]
CCDS45069.1 [Q14155-2]
CCDS86362.1 [Q14155-6]
CCDS9521.1 [Q14155-1]
RefSeqiNP_001106983.1, NM_001113511.2 [Q14155-4]
NP_001106984.1, NM_001113512.2 [Q14155-2]
NP_001106985.1, NM_001113513.1 [Q14155-1]
NP_001307780.1, NM_001320851.1 [Q14155-1]
NP_001307782.1, NM_001320853.1
NP_001307783.1, NM_001320854.1
NP_001317526.1, NM_001330597.1 [Q14155-6]
NP_001317527.1, NM_001330598.1 [Q14155-6]
NP_003890.1, NM_003899.3 [Q14155-1]
NP_663788.1, NM_145735.3 [Q14155-3]
XP_016876313.1, XM_017020824.1
XP_016876314.1, XM_017020825.1
UniGeneiHs.508738

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BY1NMR-A260-467[»]
1ZSGNMR-A179-243[»]
2L3GNMR-A1-137[»]
5SXPX-ray1.65A/B/C/D183-243[»]
ProteinModelPortaliQ14155
SMRiQ14155
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114393, 50 interactors
CORUMiQ14155
DIPiDIP-40794N
IntActiQ14155, 27 interactors
MINTiQ14155
STRINGi9606.ENSP00000364893

PTM databases

iPTMnetiQ14155
PhosphoSitePlusiQ14155

Polymorphism and mutation databases

BioMutaiARHGEF7
DMDMi50403776

Proteomic databases

EPDiQ14155
PaxDbiQ14155
PeptideAtlasiQ14155
PRIDEiQ14155
ProteomicsDBi59858
59859 [Q14155-1]
59860 [Q14155-2]
59861 [Q14155-3]
59862 [Q14155-5]
59863 [Q14155-6]

Protocols and materials databases

DNASUi8874
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000317133; ENSP00000325994; ENSG00000102606 [Q14155-3]
ENST00000375723; ENSP00000364875; ENSG00000102606 [Q14155-6]
ENST00000375736; ENSP00000364888; ENSG00000102606 [Q14155-1]
ENST00000375739; ENSP00000364891; ENSG00000102606 [Q14155-2]
ENST00000375741; ENSP00000364893; ENSG00000102606 [Q14155-4]
ENST00000426073; ENSP00000397068; ENSG00000102606 [Q14155-1]
GeneIDi8874
KEGGihsa:8874
UCSCiuc001vrr.3 human [Q14155-4]

Organism-specific databases

CTDi8874
DisGeNETi8874
EuPathDBiHostDB:ENSG00000102606.17
GeneCardsiARHGEF7
H-InvDBiHIX0037536
HGNCiHGNC:15607 ARHGEF7
HPAiHPA004744
MIMi605477 gene
neXtProtiNX_Q14155
OpenTargetsiENSG00000102606
PharmGKBiPA24977
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2070 Eukaryota
ENOG410XNNP LUCA
GeneTreeiENSGT00930000150955
HOVERGENiHBG050569
InParanoidiQ14155
KOiK13710
OrthoDBiEOG091G04XA
PhylomeDBiQ14155
TreeFamiTF316105

Enzyme and pathway databases

ReactomeiR-HSA-182971 EGFR downregulation
R-HSA-193648 NRAGE signals death through JNK
R-HSA-194840 Rho GTPase cycle
R-HSA-3928664 Ephrin signaling
R-HSA-416482 G alpha (12/13) signalling events
SignaLinkiQ14155
SIGNORiQ14155

Miscellaneous databases

ChiTaRSiARHGEF7 human
EvolutionaryTraceiQ14155
GeneWikiiARHGEF7
GenomeRNAii8874
PROiPR:Q14155
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000102606 Expressed in 224 organ(s), highest expression level in corpus callosum
ExpressionAtlasiQ14155 baseline and differential
GenevisibleiQ14155 HS

Family and domain databases

CDDicd00160 RhoGEF, 1 hit
cd12061 SH3_betaPIX, 1 hit
Gene3Di1.10.418.10, 1 hit
1.20.900.10, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR035789 BetaPIX_SH3
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR001331 GDS_CDC24_CS
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PfamiView protein in Pfam
PF00307 CH, 1 hit
PF00169 PH, 1 hit
PF00621 RhoGEF, 1 hit
PF07653 SH3_2, 1 hit
PRINTSiPR00452 SH3DOMAIN
SMARTiView protein in SMART
SM00033 CH, 1 hit
SM00233 PH, 1 hit
SM00325 RhoGEF, 1 hit
SM00326 SH3, 1 hit
SUPFAMiSSF47576 SSF47576, 1 hit
SSF48065 SSF48065, 1 hit
SSF50044 SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS50021 CH, 1 hit
PS00741 DH_1, 1 hit
PS50010 DH_2, 1 hit
PS50003 PH_DOMAIN, 1 hit
PS50002 SH3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiARHG7_HUMAN
AccessioniPrimary (citable) accession number: Q14155
Secondary accession number(s): B1ALK6
, B1ALK8, Q3LIA4, Q5W9H0, Q6P9G3, Q6PII2, Q86W63, Q8N3M1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 19, 2004
Last modified: November 7, 2018
This is version 204 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
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