UniProtKB - Q14152 (EIF3A_HUMAN)

BLAST

>sp|Q14152|EIF3A_HUMAN Eukaryotic translation initiation factor 3 subunit A OS=Homo sapiens OX=9606 GN=EIF3A PE=1 SV=1
MPAYFQRPENALKRANEFLEVGKKQPALDVLYDVMKSKKHRTWQKIHEPIMLKYLELCVD
LRKSHLAKEGLYQYKNICQQVNIKSLEDVVRAYLKMAEEKTEAAKEESQQMVLDIEDLDN
IQTPESVLLSAVSGEDTQDRTDRLLLTPWVKFLWESYRQCLDLLRNNSRVERLYHDIAQQ
AFKFCLQYTRKAEFRKLCDNLRMHLSQIQRHHNQSTAINLNNPESQSMHLETRLVQLDSA
ISMELWQEAFKAVEDIHGLFSLSKKPPKPQLMANYYNKVSTVFWKSGNALFHASTLHRLY
HLSREMRKNLTQDEMQRMSTRVLLATLSIPITPERTDIARLLDMDGIIVEKQRRLATLLG
LQAPPTRIGLINDMVRFNVLQYVVPEVKDLYNWLEVEFNPLKLCERVTKVLNWVREQPEK
EPELQQYVPQLQNNTILRLLQQVSQIYQSIEFSRLTSLVPFVDAFQLERAIVDAARHCDL
QVRIDHTSRTLSFGSDLNYATREDAPIGPHLQSMPSEQIRNQLTAMSSVLAKALEVIKPA
HILQEKEEQHQLAVTAYLKNSRKEHQRILARRQTIEERKERLESLNIQREKEELEQREAE
LQKVRKAEEERLRQEAKEREKERILQEHEQIKKKTVRERLEQIKKTELGAKAFKDIDIED
LEELDPDFIMAKQVEQLEKEKKELQERLKNQEKKIDYFERAKRLEEIPLIKSAYEEQRIK
DMDLWEQQEEERITTMQLEREKALEHKNRMSRMLEDRDLFVMRLKAARQSVYEEKLKQFE
ERLAEERHNRLEERKRQRKEERRITYYREKEEEEQRRAEEQMLKEREERERAERAKREEE
LREYQERVKKLEEVERKKRQRELEIEERERRREEERRLGDSSLSRKDSRWGDRDSEGTWR
KGPEADSEWRRGPPEKEWRRGEGRDEDRSHRRDEERPRRLGDDEDREPSLRPDDDRVPRR
GMDDDRGPRRGPEEDRFSRRGADDDRPSWRNTDDDRPPRRIADEDRGNWRHADDDRPPRR
GLDEDRGSWRTADEDRGPRRGMDDDRGPRRGGADDERSSWRNADDDRGPRRGLDDDRGPR
RGMDDDRGPRRGMDDDRGPRRGMDDDRGPRRGLDDDRGPWRNADDDRIPRRGAEDDRGPW
RNMDDDRLSRRADDDRFPRRGDDSRPGPWRPLVKPGGWREKEKAREESWGPPRESRPSEE
REWDREKERDRDNQDREENDKDPERERDRERDVDREDRFRRPRDEGGWRRGPAEESSSWR
DSSRRDDRDRDDRRRERDDRRDLRERRDLRDDRDRRGPPLRSEREEVSSWRRADDRKDDR
VEERDPPRRVPPPALSRDRERDRDREREGEKEKASWRAEKDRESLRRTKNETDEDGWTTV
RR

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History
Entry version 184 (12 Sep 2018)
Sequence version 1 (01 Nov 1996)
Previous versions | rss
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Protein

Eukaryotic translation initiation factor 3 subunit A

Gene

EIF3A

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632, PubMed:11169732). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773, PubMed:27462815).UniRule annotation4 Publications

(Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 (PubMed:18056426).1 Publication

GO - Molecular functionⁱ

mRNA binding Source: GO_Central
receptor tyrosine kinase binding Source: Ensembl
RNA binding
Source: UniProtKB
Inferred from direct assayⁱ
- 25849773
- 27462815
structural molecule activity
Source: UniProtKB
Non-traceable author statementⁱ
- 9150439
translation initiation factor activity Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

formation of cytoplasmic translation initiation complex
Source: UniProtKB
Inferred from direct assayⁱ
- 17581632
IRES-dependent viral translational initiation
Source: UniProtKB
Inferred from direct assayⁱ
negative regulation of ERK1 and ERK2 cascade Source: Ensembl
translational initiation Source: Reactome
translation reinitiation Source: GO_Central
viral translational termination-reinitiation
Source: UniProtKB
Inferred from direct assayⁱ
- 21347434

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Initiation factor, RNA-binding
Biological process	Protein biosynthesis

Enzyme and pathway databases

Reactomeⁱ	R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-72649 Translation initiation complex formation R-HSA-72689 Formation of a pool of free 40S subunits R-HSA-72695 Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72702 Ribosomal scanning and start codon recognition R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit

Reactomeⁱ

R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-72649 Translation initiation complex formation
R-HSA-72689 Formation of a pool of free 40S subunits
R-HSA-72695 Formation of the ternary complex, and subsequently, the 43S complex
R-HSA-72702 Ribosomal scanning and start codon recognition
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit

Protein family/group databases

MoonProtⁱ	Q14152

MoonProtⁱ

Q14152

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Eukaryotic translation initiation factor 3 subunit AUniRule annotation Short name: eIF3aUniRule annotation Alternative name(s): Eukaryotic translation initiation factor 3 subunit 10UniRule annotation eIF-3-thetaUniRule annotation eIF3 p167 eIF3 p180 eIF3 p185
Gene namesⁱ	Name:EIF3AUniRule annotation Synonyms:EIF3S10UniRule annotation, KIAA0139
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 10

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000107581.12
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:3271 EIF3A
MIMⁱ	602039 gene
neXtProtⁱ	NX_Q14152

Keywords - Cellular componentⁱ

Cytoplasm

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	8661
Open Targets More...OpenTargetsⁱ	ENSG00000107581
PharmGKBⁱ	PA27699

Polymorphism and mutation databases

BioMutaⁱ	EIF3A
DMDMⁱ	6685537

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedUniRule annotation2 Publications
ChainⁱPRO_0000123537	2 – 1382	Eukaryotic translation initiation factor 3 subunit AAdd BLAST		1381

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	68	N6-acetyllysineCombined sources	1
Modified residueⁱ	492	PhosphoserineCombined sources	1
Modified residueⁱ	584	PhosphoserineCombined sources	1
Modified residueⁱ	881	PhosphoserineUniRule annotationCombined sources1 Publication	1
Modified residueⁱ	882	PhosphoserineCombined sources	1
Modified residueⁱ	895	PhosphoserineCombined sources	1
Modified residueⁱ	949	PhosphoserineCombined sources	1
Modified residueⁱ	1028	PhosphoserineCombined sources	1
Modified residueⁱ	1188	PhosphoserineCombined sources	1
Modified residueⁱ	1198	PhosphoserineUniRule annotationCombined sources1 Publication	1
Modified residueⁱ	1262	PhosphoserineCombined sources	1
Modified residueⁱ	1336	PhosphoserineUniRule annotationCombined sources1 Publication	1
Modified residueⁱ	1364	PhosphoserineUniRule annotation1 Publication	1

Post-translational modificationⁱ

Phosphorylated. Phosphorylation is enhanced upon serum stimulation.UniRule annotation1 Publication

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

EPDⁱ	Q14152
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q14152
PaxDbⁱ	Q14152
PeptideAtlas More...PeptideAtlasⁱ	Q14152
PRIDEⁱ	Q14152
ProteomicsDBⁱ	59854

2D gel databases

UCD-2DPAGEⁱ	Q14152

UCD-2DPAGEⁱ

Q14152

PTM databases

iPTMnetⁱ	Q14152
PhosphoSitePlusⁱ	Q14152
SwissPalmⁱ	Q14152

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000107581 Expressed in 239 organ(s), highest expression level in substantia nigra
CleanExⁱ	HS_EIF3A
Genevisibleⁱ	Q14152 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA038315 HPA038316

HPAⁱ

HPA038315
HPA038316

Interactionⁱ

Subunit structureⁱ

Interacts with EIF4G1 (By similarity). Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3L and EIF3K. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Also interacts with KRT7 and PIWIL2.By similarity8 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
EIF1	P41567	2	EBI-366617,EBI-726200
EIF1AX	P47813	2	EBI-366617,EBI-1045377
EIF3B	P55884	9	EBI-366617,EBI-366696
EIF3C	Q99613	14	EBI-366617,EBI-353741
Eif3f	Q9DCH4	4	EBI-366617,EBI-1634316	From Mus musculus.
KRT7	P08729	3	EBI-366617,EBI-297833
ORF	Q9Q2G4	5	EBI-366617,EBI-6248094	From Human immunodeficiency virus 1.
UPF1	Q92900-2	5	EBI-366617,EBI-373492

GO - Molecular functionⁱ

receptor tyrosine kinase binding Source: Ensembl

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	114210, 123 interactors
CORUMⁱ	Q14152
Database of interacting proteins More...DIPⁱ	DIP-31114N
IntActⁱ	Q14152, 71 interactors
Molecular INTeraction database More...MINTⁱ	Q14152
STRINGⁱ	9606.ENSP00000358140

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	10 – 20	Combined sources	11
Helixⁱ	24 – 35	Combined sources	12
Helixⁱ	38 – 40	Combined sources	3
Helixⁱ	47 – 60	Combined sources	14
Helixⁱ	64 – 78	Combined sources	15
Helixⁱ	84 – 107	Combined sources	24
Helixⁱ	147 – 164	Combined sources	18
Helixⁱ	168 – 170	Combined sources	3
Helixⁱ	171 – 187	Combined sources	17
Helixⁱ	191 – 213	Combined sources	23
Helixⁱ	223 – 242	Combined sources	20
Helixⁱ	246 – 262	Combined sources	17
Helixⁱ	269 – 286	Combined sources	18
Helixⁱ	289 – 305	Combined sources	17
Beta strandⁱ	306 – 309	Combined sources	4
Helixⁱ	312 – 327	Combined sources	16
Helixⁱ	336 – 342	Combined sources	7
Beta strandⁱ	346 – 348	Combined sources	3
Helixⁱ	354 – 358	Combined sources	5
Helixⁱ	367 – 375	Combined sources	9
Helixⁱ	377 – 381	Combined sources	5
Helixⁱ	385 – 395	Combined sources	11
Helixⁱ	400 – 416	Combined sources	17
Helixⁱ	420 – 425	Combined sources	6
Helixⁱ	428 – 446	Combined sources	19
Beta strandⁱ	448 – 451	Combined sources	4
Helixⁱ	452 – 458	Combined sources	7
Helixⁱ	464 – 476	Combined sources	13
Beta strandⁱ	483 – 485	Combined sources	3
Turnⁱ	486 – 489	Combined sources	4
Beta strandⁱ	490 – 492	Combined sources	3

Show more details

3D structure databases

ProteinModelPortalⁱ	Q14152
SMRⁱ	Q14152
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	315 – 498	PCIPROSITE-ProRule annotationAdd BLAST	184
Repeatⁱ	925 – 934	1	10
Repeatⁱ	935 – 942	2; truncated	8
Repeatⁱ	943 – 952	3	10
Repeatⁱ	953 – 962	4	10
Repeatⁱ	963 – 972	5	10
Repeatⁱ	973 – 982	6	10
Repeatⁱ	983 – 992	7	10
Repeatⁱ	993 – 1002	8	10
Repeatⁱ	1003 – 1012	9	10
Repeatⁱ	1013 – 1022	10	10
Repeatⁱ	1023 – 1032	11	10
Repeatⁱ	1033 – 1042	12	10
Repeatⁱ	1043 – 1052	13	10
Repeatⁱ	1054 – 1063	14	10
Repeatⁱ	1064 – 1073	15	10
Repeatⁱ	1074 – 1083	16	10
Repeatⁱ	1084 – 1093	17	10
Repeatⁱ	1094 – 1103	18	10
Repeatⁱ	1104 – 1113	19	10
Repeatⁱ	1114 – 1123	20	10
Repeatⁱ	1124 – 1133	21	10
Repeatⁱ	1134 – 1143	22	10
Repeatⁱ	1144 – 1152	23; truncated	9
Repeatⁱ	1153 – 1162	24	10
Repeatⁱ	1163 – 1172	25; approximate	10

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	664 – 835	Interaction with EIF3BAdd BLAST		172
Regionⁱ	925 – 1172	25 X 10 AA approximate tandem repeats of [DE]-[DE]-[DE]-R-[SEVGFPILV]-[HPSN]-[RSW]-[RL]-[DRGTIHN]-[EPMANLGDT]Add BLAST		248

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	82 – 120	UniRule annotationAdd BLAST		39

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	576 – 875	Glu-richAdd BLAST		300
Compositional biasⁱ	925 – 1294	Asp-richAdd BLAST		370

Sequence similaritiesⁱ

Belongs to the eIF-3 subunit A family.UniRule annotation

Keywords - Domainⁱ

Coiled coil, Repeat

Phylogenomic databases

eggNOGⁱ	KOG2072 Eukaryota ENOG410XQ37 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00730000111063
HOGENOMⁱ	HOG000246822
HOVERGENⁱ	HBG006128
InParanoidⁱ	Q14152
KEGG Orthology (KO) More...KOⁱ	K03254
OMAⁱ	QDRDEND
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G01VW
PhylomeDBⁱ	Q14152
TreeFamⁱ	TF101522

Family and domain databases

HAMAPⁱ	MF_03000 eIF3a, 1 hit
InterProⁱ	View protein in InterPro IPR027512 EIF3A IPR000717 PCI_dom
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01399 PCI, 1 hit
SMARTⁱ	View protein in SMART SM00088 PINT, 1 hit
PROSITEⁱ	View protein in PROSITE PS50250 PCI, 1 hit

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform 1 (identifier: Q14152-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPAYFQRPEN ALKRANEFLE VGKKQPALDV LYDVMKSKKH RTWQKIHEPI 
        60         70         80         90        100
MLKYLELCVD LRKSHLAKEG LYQYKNICQQ VNIKSLEDVV RAYLKMAEEK 
       110        120        130        140        150
TEAAKEESQQ MVLDIEDLDN IQTPESVLLS AVSGEDTQDR TDRLLLTPWV 
       160        170        180        190        200
KFLWESYRQC LDLLRNNSRV ERLYHDIAQQ AFKFCLQYTR KAEFRKLCDN 
       210        220        230        240        250
LRMHLSQIQR HHNQSTAINL NNPESQSMHL ETRLVQLDSA ISMELWQEAF 
       260        270        280        290        300
KAVEDIHGLF SLSKKPPKPQ LMANYYNKVS TVFWKSGNAL FHASTLHRLY 
       310        320        330        340        350
HLSREMRKNL TQDEMQRMST RVLLATLSIP ITPERTDIAR LLDMDGIIVE 
       360        370        380        390        400
KQRRLATLLG LQAPPTRIGL INDMVRFNVL QYVVPEVKDL YNWLEVEFNP 
       410        420        430        440        450
LKLCERVTKV LNWVREQPEK EPELQQYVPQ LQNNTILRLL QQVSQIYQSI 
       460        470        480        490        500
EFSRLTSLVP FVDAFQLERA IVDAARHCDL QVRIDHTSRT LSFGSDLNYA 
       510        520        530        540        550
TREDAPIGPH LQSMPSEQIR NQLTAMSSVL AKALEVIKPA HILQEKEEQH 
       560        570        580        590        600
QLAVTAYLKN SRKEHQRILA RRQTIEERKE RLESLNIQRE KEELEQREAE 
       610        620        630        640        650
LQKVRKAEEE RLRQEAKERE KERILQEHEQ IKKKTVRERL EQIKKTELGA 
       660        670        680        690        700
KAFKDIDIED LEELDPDFIM AKQVEQLEKE KKELQERLKN QEKKIDYFER 
       710        720        730        740        750
AKRLEEIPLI KSAYEEQRIK DMDLWEQQEE ERITTMQLER EKALEHKNRM 
       760        770        780        790        800
SRMLEDRDLF VMRLKAARQS VYEEKLKQFE ERLAEERHNR LEERKRQRKE 
       810        820        830        840        850
ERRITYYREK EEEEQRRAEE QMLKEREERE RAERAKREEE LREYQERVKK 
       860        870        880        890        900
LEEVERKKRQ RELEIEERER RREEERRLGD SSLSRKDSRW GDRDSEGTWR 
       910        920        930        940        950
KGPEADSEWR RGPPEKEWRR GEGRDEDRSH RRDEERPRRL GDDEDREPSL 
       960        970        980        990       1000
RPDDDRVPRR GMDDDRGPRR GPEEDRFSRR GADDDRPSWR NTDDDRPPRR 
      1010       1020       1030       1040       1050
IADEDRGNWR HADDDRPPRR GLDEDRGSWR TADEDRGPRR GMDDDRGPRR 
      1060       1070       1080       1090       1100
GGADDERSSW RNADDDRGPR RGLDDDRGPR RGMDDDRGPR RGMDDDRGPR 
      1110       1120       1130       1140       1150
RGMDDDRGPR RGLDDDRGPW RNADDDRIPR RGAEDDRGPW RNMDDDRLSR 
      1160       1170       1180       1190       1200
RADDDRFPRR GDDSRPGPWR PLVKPGGWRE KEKAREESWG PPRESRPSEE 
      1210       1220       1230       1240       1250
REWDREKERD RDNQDREEND KDPERERDRE RDVDREDRFR RPRDEGGWRR 
      1260       1270       1280       1290       1300
GPAEESSSWR DSSRRDDRDR DDRRRERDDR RDLRERRDLR DDRDRRGPPL 
      1310       1320       1330       1340       1350
RSEREEVSSW RRADDRKDDR VEERDPPRRV PPPALSRDRE RDRDREREGE 
      1360       1370       1380 
KEKASWRAEK DRESLRRTKN ETDEDGWTTV RR

Length:1,382

Mass (Da):166,569

Last modified:November 1, 1996 - v1

Checksum:ⁱ485C01B28D67EBBA

Isoform 2 (identifier: Q14152-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-34: Missing.

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        10         20         30         40         50
MKSKKHRTWQ KIHEPIMLKY LELCVDLRKS HLAKEGLYQY KNICQQVNIK 
        60         70         80         90        100
SLEDVVRAYL KMAEEKTEAA KEESQQMVLD IEDLDNIQTP ESVLLSAVSG 
       110        120        130        140        150
EDTQDRTDRL LLTPWVKFLW ESYRQCLDLL RNNSRVERLY HDIAQQAFKF 
       160        170        180        190        200
CLQYTRKAEF RKLCDNLRMH LSQIQRHHNQ STAINLNNPE SQSMHLETRL 
       210        220        230        240        250
VQLDSAISME LWQEAFKAVE DIHGLFSLSK KPPKPQLMAN YYNKVSTVFW 
       260        270        280        290        300
KSGNALFHAS TLHRLYHLSR EMRKNLTQDE MQRMSTRVLL ATLSIPITPE 
       310        320        330        340        350
RTDIARLLDM DGIIVEKQRR LATLLGLQAP PTRIGLINDM VRFNVLQYVV 
       360        370        380        390        400
PEVKDLYNWL EVEFNPLKLC ERVTKVLNWV REQPEKEPEL QQYVPQLQNN 
       410        420        430        440        450
TILRLLQQVS QIYQSIEFSR LTSLVPFVDA FQLERAIVDA ARHCDLQVRI 
       460        470        480        490        500
DHTSRTLSFG SDLNYATRED APIGPHLQSM PSEQIRNQLT AMSSVLAKAL 
       510        520        530        540        550
EVIKPAHILQ EKEEQHQLAV TAYLKNSRKE HQRILARRQT IEERKERLES 
       560        570        580        590        600
LNIQREKEEL EQREAELQKV RKAEEERLRQ EAKEREKERI LQEHEQIKKK 
       610        620        630        640        650
TVRERLEQIK KTELGAKAFK DIDIEDLEEL DPDFIMAKQV EQLEKEKKEL 
       660        670        680        690        700
QERLKNQEKK IDYFERAKRL EEIPLIKSAY EEQRIKDMDL WEQQEEERIT 
       710        720        730        740        750
TMQLEREKAL EHKNRMSRML EDRDLFVMRL KAARQSVYEE KLKQFEERLA 
       760        770        780        790        800
EERHNRLEER KRQRKEERRI TYYREKEEEE QRRAEEQMLK EREERERAER 
       810        820        830        840        850
AKREEELREY QERVKKLEEV ERKKRQRELE IEERERRREE ERRLGDSSLS 
       860        870        880        890        900
RKDSRWGDRD SEGTWRKGPE ADSEWRRGPP EKEWRRGEGR DEDRSHRRDE 
       910        920        930        940        950
ERPRRLGDDE DREPSLRPDD DRVPRRGMDD DRGPRRGPEE DRFSRRGADD 
       960        970        980        990       1000
DRPSWRNTDD DRPPRRIADE DRGNWRHADD DRPPRRGLDE DRGSWRTADE 
      1010       1020       1030       1040       1050
DRGPRRGMDD DRGPRRGGAD DERSSWRNAD DDRGPRRGLD DDRGPRRGMD 
      1060       1070       1080       1090       1100
DDRGPRRGMD DDRGPRRGMD DDRGPRRGLD DDRGPWRNAD DDRIPRRGAE 
      1110       1120       1130       1140       1150
DDRGPWRNMD DDRLSRRADD DRFPRRGDDS RPGPWRPLVK PGGWREKEKA 
      1160       1170       1180       1190       1200
REESWGPPRE SRPSEEREWD REKERDRDNQ DREENDKDPE RERDRERDVD 
      1210       1220       1230       1240       1250
REDRFRRPRD EGGWRRGPAE ESSSWRDSSR RDDRDRDDRR RERDDRRDLR 
      1260       1270       1280       1290       1300
ERRDLRDDRD RRGPPLRSER EEVSSWRRAD DRKDDRVEER DPPRRVPPPA 
      1310       1320       1330       1340 
LSRDRERDRD REREGEKEKA SWRAEKDRES LRRTKNETDE DGWTTVRR

Note: No experimental confirmation available.

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Length:1,348

Mass (Da):162,636

Checksum:ⁱ97F42E357D8B5405

Sequence cautionⁱ

The sequence BAA09488 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	520	R → G in BAG63833 (PubMed:14702039).Curated	1
Sequence conflictⁱ	983	D → G in BAG63833 (PubMed:14702039).Curated	1
Sequence conflictⁱ	1272	D → G in BAG63833 (PubMed:14702039).Curated	1

Mass spectrometryⁱ

Molecular mass is 166758.3 Da from positions 1 - 1382. 1 Publication

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_024438	386	E → K1 PublicationCorresponds to variant dbSNP:rs967185Ensembl.	1
Natural variantⁱVAR_048921	694	K → N. Corresponds to variant dbSNP:rs431898Ensembl.	1
Natural variantⁱVAR_048922	993	D → E. Corresponds to variant dbSNP:rs532138Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_055471	1 – 34	Missing in isoform 2. 1 PublicationAdd BLAST		34

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U58046 mRNA Translation: AAB41584.1 U58047 Genomic DNA Translation: AAB41586.1 U78311 mRNA Translation: AAB80695.1 D50929 mRNA Translation: BAA09488.2 Different initiation. AK302575 mRNA Translation: BAG63833.1 AL355598 Genomic DNA No translation available. CH471066 Genomic DNA Translation: EAW49408.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS7608.1 [Q14152-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_003741.1, NM_003750.2 [Q14152-1]
UniGeneⁱ	Hs.523299 Hs.713331

Genome annotation databases

Ensemblⁱ	ENST00000369144; ENSP00000358140; ENSG00000107581 [Q14152-1] ENST00000541549; ENSP00000438178; ENSG00000107581 [Q14152-1]
GeneIDⁱ	8661
KEGGⁱ	hsa:8661
UCSC genome browser More...UCSCⁱ	uc001ldu.4 human [Q14152-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q14152	Isoform 2 of Eukaryotic translation initiation factor 3 subunit A		HUMAN		1348	UniRef90_Q14152
Eukaryotic translation initiation factor 3 subunit A		PONAB		1392
Eukaryotic translation initiation factor 3 subunit A		PAPAN		1392
Eukaryotic translation initiation factor 3 subunit A		MYOLU		1384
Eukaryotic translation initiation factor 3 subunit A		PANTR		1382
+47

Protein	Similar proteins		Species	Score	Length	Source
Q14152	Eukaryotic translation initiation factor 3 subunit A		XENTR		1391	UniRef50_Q14152
Eukaryotic translation initiation factor 3 subunit A		XENLA		1424
Eukaryotic translation initiation factor 3 subunit A		RAT		1354
Eukaryotic translation initiation factor 3 subunit A		MOUSE		1344
Eukaryotic translation initiation factor 3 subunit A		DANRE		1267
+425

Cross-referencesⁱ

Web resourcesⁱ

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U58046 mRNA Translation: AAB41584.1 U58047 Genomic DNA Translation: AAB41586.1 U78311 mRNA Translation: AAB80695.1 D50929 mRNA Translation: BAA09488.2 Different initiation. AK302575 mRNA Translation: BAG63833.1 AL355598 Genomic DNA No translation available. CH471066 Genomic DNA Translation: EAW49408.1
CCDSⁱ	CCDS7608.1 [Q14152-1]
RefSeqⁱ	NP_003741.1, NM_003750.2 [Q14152-1]
UniGeneⁱ	Hs.523299 Hs.713331

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	3J8B	electron microscopy	-	A	1-494	[»]
	3J8C	electron microscopy	-	A	1-494	[»]
ProteinModelPortalⁱ	Q14152
SMRⁱ	Q14152
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	114210, 123 interactors
CORUMⁱ	Q14152
DIPⁱ	DIP-31114N
IntActⁱ	Q14152, 71 interactors
MINTⁱ	Q14152
STRINGⁱ	9606.ENSP00000358140

Protein family/group databases

MoonProtⁱ	Q14152

MoonProtⁱ

Q14152

PTM databases

iPTMnetⁱ	Q14152
PhosphoSitePlusⁱ	Q14152
SwissPalmⁱ	Q14152

Polymorphism and mutation databases

BioMutaⁱ	EIF3A
DMDMⁱ	6685537

2D gel databases

UCD-2DPAGEⁱ	Q14152

UCD-2DPAGEⁱ

Q14152

Proteomic databases

EPDⁱ	Q14152
MaxQBⁱ	Q14152
PaxDbⁱ	Q14152
PeptideAtlasⁱ	Q14152
PRIDEⁱ	Q14152
ProteomicsDBⁱ	59854

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000369144; ENSP00000358140; ENSG00000107581 [Q14152-1] ENST00000541549; ENSP00000438178; ENSG00000107581 [Q14152-1]
GeneIDⁱ	8661
KEGGⁱ	hsa:8661
UCSCⁱ	uc001ldu.4 human [Q14152-1]

Organism-specific databases

CTDⁱ	8661
DisGeNETⁱ	8661
EuPathDBⁱ	HostDB:ENSG00000107581.12
GeneCardsⁱ	EIF3A
H-InvDBⁱ	HIX0170434
HGNCⁱ	HGNC:3271 EIF3A
HPAⁱ	HPA038315 HPA038316
MIMⁱ	602039 gene
neXtProtⁱ	NX_Q14152
OpenTargetsⁱ	ENSG00000107581
PharmGKBⁱ	PA27699
HUGEⁱ	Search...
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG2072 Eukaryota ENOG410XQ37 LUCA
GeneTreeⁱ	ENSGT00730000111063
HOGENOMⁱ	HOG000246822
HOVERGENⁱ	HBG006128
InParanoidⁱ	Q14152
KOⁱ	K03254
OMAⁱ	QDRDEND
OrthoDBⁱ	EOG091G01VW
PhylomeDBⁱ	Q14152
TreeFamⁱ	TF101522

Enzyme and pathway databases

Reactomeⁱ	R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-72649 Translation initiation complex formation R-HSA-72689 Formation of a pool of free 40S subunits R-HSA-72695 Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72702 Ribosomal scanning and start codon recognition R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit

Reactomeⁱ

Miscellaneous databases

ChiTaRSⁱ	EIF3A human
GeneWikiⁱ	EIF3A
GenomeRNAiⁱ	8661
Protein Ontology More...PROⁱ	PR:Q14152
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000107581 Expressed in 239 organ(s), highest expression level in substantia nigra
CleanExⁱ	HS_EIF3A
Genevisibleⁱ	Q14152 HS

Family and domain databases

HAMAPⁱ	MF_03000 eIF3a, 1 hit
InterProⁱ	View protein in InterPro IPR027512 EIF3A IPR000717 PCI_dom
Pfamⁱ	View protein in Pfam PF01399 PCI, 1 hit
SMARTⁱ	View protein in SMART SM00088 PINT, 1 hit
PROSITEⁱ	View protein in PROSITE PS50250 PCI, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	EIF3A_HUMAN
Accessionⁱ	Q14152Primary (citable) accession number: Q14152 Secondary accession number(s): B1AMV5 , B4DYS1, F5H335, O00653, Q15778
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
	Last sequence update:	November 1, 1996
	Last modified:	September 12, 2018
	This is version 184 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

UniProtKB

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Annotation systems

Supporting data

UniProtKB - Q14152 (EIF3A_HUMAN)

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Eukaryotic translation initiation factor 3 subunit A

EIF3A

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Cytoskeleton

Cytosol

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

2D gel databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Coiled coil

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

<p>This subsection of the ‘Sequence’ section reports information derived from mass spectrometry experiments done on the entire protein or on biologically active derived peptide(s).<p><a href='/help/mass_spectrometry' target='_top'>More...</a></p>Mass spectrometryi

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

2D gel databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Mass spectrometryⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ