UniProtKB - Q14149 (MORC3_HUMAN)
Protein
MORC family CW-type zinc finger protein 3
Gene
MORC3
Organism
Homo sapiens (Human)
Status
Functioni
Nuclear factor which forms MORC3-NBs (nuclear bodies) via an ATP-dependent mechanism (PubMed:20501696). Sumoylated MORC3-NBs can also associate with PML-NBs (PubMed:20501696). Recruits TP53 and SP100 to PML-NBs, thus regulating TP53 activity (PubMed:17332504). Binds RNA in vitro (PubMed:11927593). May be required for influenza A transcription during viral infection (PubMed:26202233).4 Publications
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 404 – 454 | CW-typePROSITE-ProRule annotationAdd BLAST | 51 |
GO - Molecular functioni
- RNA binding Source: UniProtKB-KW
- zinc ion binding Source: InterPro
GO - Biological processi
- cell aging Source: MGI
- maintenance of protein location in nucleus Source: MGI
- negative regulation of fibroblast proliferation Source: MGI
- peptidyl-serine phosphorylation Source: MGI
- post-embryonic development Source: Ensembl
- protein phosphorylation Source: MGI
- protein stabilization Source: MGI
- viral process Source: UniProtKB-KW
Keywordsi
Molecular function | RNA-binding |
Biological process | Host-virus interaction |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: MORC family CW-type zinc finger protein 3Alternative name(s): Nuclear matrix protein 21 Publication Zinc finger CW-type coiled-coil domain protein 3 |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:23572 MORC3 |
MIMi | 610078 gene |
neXtProti | NX_Q14149 |
Subcellular locationi
Nucleus
- nucleoplasm 2 Publications
- Nucleus matrix 2 Publications
- PML body 1 Publication
Note: Also found in PML-independent nuclear bodies. Localization to nuclear bodies is ATP-dependent.1 Publication
Nucleus
- nuclear matrix Source: UniProtKB-SubCell
- nucleoplasm Source: HPA
- PML body Source: MGI
Keywords - Cellular componenti
NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 35 | E → A: Fails to localize to PML nuclear bodies and activate TP53. 1 Publication | 1 | |
Mutagenesisi | 67 | D → N: Forms nuclear bodies, but rapidly diffuses throughout the nucleus under conditions of ATP depletion. 1 Publication | 1 | |
Mutagenesisi | 101 | G → A: Diffuse nuclear localization. Fails to form nuclear bodies in the presence of ATP. 1 Publication | 1 | |
Mutagenesisi | 419 | W → A: Diffuse nuclear localization, possibly due to loss of DNA or nucleosome binding. 1 Publication | 1 | |
Mutagenesisi | 597 | K → R: Loss of sumoylation; when associated with R-650; R-651; R-740 and R-794. 1 Publication | 1 | |
Mutagenesisi | 650 | K → R: Loss of sumoylation; when associated with R-597; R-651; R-740 and R-794. 1 Publication | 1 | |
Mutagenesisi | 651 | K → R: Loss of sumoylation; when associated with R-597; R-650; R-740 and R-794. 1 Publication | 1 | |
Mutagenesisi | 740 | K → R: Loss of sumoylation; when associated with R-597; R-650; R-651 and R-794. 1 Publication | 1 | |
Mutagenesisi | 794 | K → R: Loss of sumoylation; when associated with R-597; R-650; R-651 and R-740. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 23515 |
OpenTargetsi | ENSG00000159256 |
PharmGKBi | PA128394632 |
Miscellaneous databases
Pharosi | Q14149 |
Polymorphism and mutation databases
BioMutai | MORC3 |
DMDMi | 108935853 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000096538 | 1 – 939 | MORC family CW-type zinc finger protein 3Add BLAST | 939 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 191 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 205 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 231 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 280 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 293 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 503 | PhosphoserineCombined sources | 1 | |
Modified residuei | 514 | PhosphoserineCombined sources | 1 | |
Modified residuei | 540 | PhosphoserineCombined sources | 1 | |
Cross-linki | 555 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 560 | PhosphoserineCombined sources | 1 | |
Cross-linki | 597 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternate1 Publication | ||
Cross-linki | 597 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources | ||
Cross-linki | 650 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternate1 Publication | ||
Cross-linki | 650 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources | ||
Cross-linki | 651 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternate1 Publication | ||
Cross-linki | 651 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources | ||
Cross-linki | 740 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternate1 Publication | ||
Cross-linki | 740 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources | ||
Modified residuei | 765 | PhosphoserineCombined sources | 1 | |
Cross-linki | 794 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternate1 Publication | ||
Cross-linki | 794 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources | ||
Cross-linki | 855 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources |
Post-translational modificationi
Sumoylation is involved in interaction with PML and localization to PML nuclear bodies.1 Publication
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q14149 |
jPOSTi | Q14149 |
MassIVEi | Q14149 |
MaxQBi | Q14149 |
PaxDbi | Q14149 |
PeptideAtlasi | Q14149 |
PRIDEi | Q14149 |
ProteomicsDBi | 59852 |
PTM databases
iPTMneti | Q14149 |
PhosphoSitePlusi | Q14149 |
Expressioni
Tissue specificityi
Expressed in heart, placenta, skeletal muscle, brain, pancreas, lung, liver, but not kidney.1 Publication
Gene expression databases
Bgeei | ENSG00000159256 Expressed in 225 organ(s), highest expression level in corpus callosum |
ExpressionAtlasi | Q14149 baseline and differential |
Genevisiblei | Q14149 HS |
Organism-specific databases
HPAi | HPA018406 HPA034848 |
Interactioni
Subunit structurei
(Microbial infection) Interacts with influenza A virus PA and PB1 polymerase subunits during infection.
1 PublicationProtein-protein interaction databases
BioGridi | 117062, 26 interactors |
IntActi | Q14149, 18 interactors |
STRINGi | 9606.ENSP00000383333 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q14149 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 326 – 353 | Nuclear matrix binding1 PublicationAdd BLAST | 28 | |
Regioni | 500 – 591 | RNA binding1 PublicationAdd BLAST | 92 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 686 – 877 | Sequence analysisAdd BLAST | 192 |
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 404 – 454 | CW-typePROSITE-ProRule annotationAdd BLAST | 51 |
Keywords - Domaini
Coiled coil, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1845 Eukaryota ENOG411033B LUCA |
GeneTreei | ENSGT00940000160495 |
HOGENOMi | HOG000246950 |
InParanoidi | Q14149 |
OMAi | KKEMCHQ |
OrthoDBi | 193855at2759 |
PhylomeDBi | Q14149 |
TreeFami | TF329118 |
Family and domain databases
Gene3Di | 3.30.565.10, 1 hit |
InterProi | View protein in InterPro IPR036890 HATPase_C_sf IPR041006 Morc_S5 IPR011124 Znf_CW |
Pfami | View protein in Pfam PF17942 Morc6_S5, 1 hit PF07496 zf-CW, 1 hit |
SUPFAMi | SSF55874 SSF55874, 1 hit |
PROSITEi | View protein in PROSITE PS51050 ZF_CW, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
Q14149-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAAQPPRGIR LSALCPKFLH TNSTSHTWPF SAVAELIDNA YDPDVNAKQI
60 70 80 90 100
WIDKTVINDH ICLTFTDNGN GMTSDKLHKM LSFGFSDKVT MNGHVPVGLY
110 120 130 140 150
GNGFKSGSMR LGKDAIVFTK NGESMSVGLL SQTYLEVIKA EHVVVPIVAF
160 170 180 190 200
NKHRQMINLA ESKASLAAIL EHSLFSTEQK LLAELDAIIG KKGTRIIIWN
210 220 230 240 250
LRSYKNATEF DFEKDKYDIR IPEDLDEITG KKGYKKQERM DQIAPESDYS
260 270 280 290 300
LRAYCSILYL KPRMQIILRG QKVKTQLVSK SLAYIERDVY RPKFLSKTVR
310 320 330 340 350
ITFGFNCRNK DHYGIMMYHR NRLIKAYEKV GCQLRANNMG VGVVGIIECN
360 370 380 390 400
FLKPTHNKQD FDYTNEYRLT ITALGEKLND YWNEMKVKKN TEYPLNLPVE
410 420 430 440 450
DIQKRPDQTW VQCDACLKWR KLPDGMDQLP EKWYCSNNPD PQFRNCEVPE
460 470 480 490 500
EPEDEDLVHP TYEKTYKKTN KEKFRIRQPE MIPRINAELL FRPTALSTPS
510 520 530 540 550
FSSPKESVPR RHLSEGTNSY ATRLLNNHQV PPQSEPESNS LKRRLSTRSS
560 570 580 590 600
ILNAKNRRLS SQFENSVYKG DDDDEDVIIL EENSTPKPAV DHDIDMKSEQ
610 620 630 640 650
SHVEQGGVQV EFVGDSEPCG QTGSTSTSSS RCDQGNTAAT QTEVPSLVVK
660 670 680 690 700
KEETVEDEID VRNDAVILPS CVEAEAKIHE TQETTDKSAD DAGCQLQELR
710 720 730 740 750
NQLLLVTEEK ENYKRQCHMF TDQIKVLQQR ILEMNDKYVK KETCHQSTET
760 770 780 790 800
DAVFLLESIN GKSESPDHMV SQYQQALEEI ERLKKQCSAL QHVKAECSQC
810 820 830 840 850
SNNESKSEMD EMAVQLDDVF RQLDKCSIER DQYKSEVELL EMEKSQIRSQ
860 870 880 890 900
CEELKTEVEQ LKSTNQQTAT DVSTSSNIEE SVNHMDGESL KLRSLRVNVG
910 920 930
QLLAMIVPDL DLQQVNYDVD VVDEILGQVV EQMSEISST
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH0YHQ4 | H0YHQ4_HUMAN | MORC family CW-type zinc finger pro... | MORC3 | 191 | Annotation score: | ||
H0YIR5 | H0YIR5_HUMAN | MORC family CW-type zinc finger pro... | MORC3 | 226 | Annotation score: |
Sequence cautioni
The sequence BAA09485 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAA89432 differs from that shown. Reason: Erroneous initiation.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D50926 mRNA Translation: BAA09485.2 Different initiation. AK292957 mRNA Translation: BAF85646.1 AP000693, AP000692 Genomic DNA Translation: BAA89432.1 Different initiation. |
CCDSi | CCDS42924.1 |
RefSeqi | NP_056173.1, NM_015358.2 |
Genome annotation databases
Ensembli | ENST00000400485; ENSP00000383333; ENSG00000159256 |
GeneIDi | 23515 |
KEGGi | hsa:23515 |
UCSCi | uc002yvi.3 human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D50926 mRNA Translation: BAA09485.2 Different initiation. AK292957 mRNA Translation: BAF85646.1 AP000693, AP000692 Genomic DNA Translation: BAA89432.1 Different initiation. |
CCDSi | CCDS42924.1 |
RefSeqi | NP_056173.1, NM_015358.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4QQ4 | X-ray | 1.75 | A/B | 400-460 | [»] | |
5SVI | X-ray | 1.61 | A | 407-453 | [»] | |
5SVX | X-ray | 1.56 | A | 407-454 | [»] | |
5SVY | X-ray | 1.05 | A | 407-455 | [»] | |
6O1E | X-ray | 2.41 | A | 1-455 | [»] | |
6O5W | X-ray | 1.41 | A | 407-455 | [»] | |
SMRi | Q14149 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGridi | 117062, 26 interactors |
IntActi | Q14149, 18 interactors |
STRINGi | 9606.ENSP00000383333 |
PTM databases
iPTMneti | Q14149 |
PhosphoSitePlusi | Q14149 |
Polymorphism and mutation databases
BioMutai | MORC3 |
DMDMi | 108935853 |
Proteomic databases
EPDi | Q14149 |
jPOSTi | Q14149 |
MassIVEi | Q14149 |
MaxQBi | Q14149 |
PaxDbi | Q14149 |
PeptideAtlasi | Q14149 |
PRIDEi | Q14149 |
ProteomicsDBi | 59852 |
Genome annotation databases
Ensembli | ENST00000400485; ENSP00000383333; ENSG00000159256 |
GeneIDi | 23515 |
KEGGi | hsa:23515 |
UCSCi | uc002yvi.3 human |
Organism-specific databases
CTDi | 23515 |
DisGeNETi | 23515 |
GeneCardsi | MORC3 |
HGNCi | HGNC:23572 MORC3 |
HPAi | HPA018406 HPA034848 |
MIMi | 610078 gene |
neXtProti | NX_Q14149 |
OpenTargetsi | ENSG00000159256 |
PharmGKBi | PA128394632 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1845 Eukaryota ENOG411033B LUCA |
GeneTreei | ENSGT00940000160495 |
HOGENOMi | HOG000246950 |
InParanoidi | Q14149 |
OMAi | KKEMCHQ |
OrthoDBi | 193855at2759 |
PhylomeDBi | Q14149 |
TreeFami | TF329118 |
Miscellaneous databases
ChiTaRSi | MORC3 human |
GeneWikii | MORC3 |
GenomeRNAii | 23515 |
Pharosi | Q14149 |
PROi | PR:Q14149 |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000159256 Expressed in 225 organ(s), highest expression level in corpus callosum |
ExpressionAtlasi | Q14149 baseline and differential |
Genevisiblei | Q14149 HS |
Family and domain databases
Gene3Di | 3.30.565.10, 1 hit |
InterProi | View protein in InterPro IPR036890 HATPase_C_sf IPR041006 Morc_S5 IPR011124 Znf_CW |
Pfami | View protein in Pfam PF17942 Morc6_S5, 1 hit PF07496 zf-CW, 1 hit |
SUPFAMi | SSF55874 SSF55874, 1 hit |
PROSITEi | View protein in PROSITE PS51050 ZF_CW, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MORC3_HUMAN | |
Accessioni | Q14149Primary (citable) accession number: Q14149 Secondary accession number(s): A8KA92, Q9UEZ2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | June 13, 2006 | |
Last modified: | October 16, 2019 | |
This is version 147 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Complete proteome, Reference proteomeDocuments
- Human chromosome 21
Human chromosome 21: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references