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Protein

MORC family CW-type zinc finger protein 3

Gene

MORC3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Nuclear factor which forms MORC3-NBs (nuclear bodies) via an ATP-dependent mechanism (PubMed:20501696). Sumoylated MORC3-NBs can also associate with PML-NBs (PubMed:20501696). Recruits TP53 and SP100 to PML-NBs, thus regulating TP53 activity (PubMed:17332504). Binds RNA in vitro (PubMed:11927593). May be required for influenza A transcription during viral infection (PubMed:26202233).4 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri404 – 454CW-typePROSITE-ProRule annotationAdd BLAST51

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRNA-binding
Biological processHost-virus interaction
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
MORC family CW-type zinc finger protein 3
Alternative name(s):
Nuclear matrix protein 21 Publication
Zinc finger CW-type coiled-coil domain protein 3
Gene namesi
Name:MORC3Imported
Synonyms:KIAA0136Imported, NXP2Imported, ZCWCC3Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

EuPathDBiHostDB:ENSG00000159256.12
HGNCiHGNC:23572 MORC3
MIMi610078 gene
neXtProtiNX_Q14149

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi35E → A: Fails to localize to PML nuclear bodies and activate TP53. 1 Publication1
Mutagenesisi67D → N: Forms nuclear bodies, but rapidly diffuses throughout the nucleus under conditions of ATP depletion. 1 Publication1
Mutagenesisi101G → A: Diffuse nuclear localization. Fails to form nuclear bodies in the presence of ATP. 1 Publication1
Mutagenesisi419W → A: Diffuse nuclear localization, possibly due to loss of DNA or nucleosome binding. 1 Publication1
Mutagenesisi597K → R: Loss of sumoylation; when associated with R-650; R-651; R-740 and R-794. 1 Publication1
Mutagenesisi650K → R: Loss of sumoylation; when associated with R-597; R-651; R-740 and R-794. 1 Publication1
Mutagenesisi651K → R: Loss of sumoylation; when associated with R-597; R-650; R-740 and R-794. 1 Publication1
Mutagenesisi740K → R: Loss of sumoylation; when associated with R-597; R-650; R-651 and R-794. 1 Publication1
Mutagenesisi794K → R: Loss of sumoylation; when associated with R-597; R-650; R-651 and R-740. 1 Publication1

Organism-specific databases

DisGeNETi23515
OpenTargetsiENSG00000159256
PharmGKBiPA128394632

Polymorphism and mutation databases

BioMutaiMORC3
DMDMi108935853

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000965381 – 939MORC family CW-type zinc finger protein 3Add BLAST939

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki191Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki205Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki231Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki280Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki293Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei503PhosphoserineCombined sources1
Modified residuei514PhosphoserineCombined sources1
Modified residuei540PhosphoserineCombined sources1
Cross-linki555Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei560PhosphoserineCombined sources1
Cross-linki597Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternate1 Publication
Cross-linki597Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Cross-linki650Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternate1 Publication
Cross-linki650Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Cross-linki651Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternate1 Publication
Cross-linki651Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Cross-linki740Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternate1 Publication
Cross-linki740Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei765PhosphoserineCombined sources1
Cross-linki794Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternate1 Publication
Cross-linki794Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Cross-linki855Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Post-translational modificationi

Sumoylation is involved in interaction with PML and localization to PML nuclear bodies.1 Publication

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ14149
MaxQBiQ14149
PaxDbiQ14149
PeptideAtlasiQ14149
PRIDEiQ14149
ProteomicsDBi59852

PTM databases

iPTMnetiQ14149
PhosphoSitePlusiQ14149

Expressioni

Tissue specificityi

Expressed in heart, placenta, skeletal muscle, brain, pancreas, lung, liver, but not kidney.1 Publication

Gene expression databases

BgeeiENSG00000159256 Expressed in 225 organ(s), highest expression level in corpus callosum
CleanExiHS_MORC3
ExpressionAtlasiQ14149 baseline and differential
GenevisibleiQ14149 HS

Organism-specific databases

HPAiHPA018406
HPA034848

Interactioni

Subunit structurei

Homodimer (PubMed:17332504). The sumoylated form interacts with PML (via SUMO-interacting motif) (PubMed:20501696, PubMed:17332504). Interacts with PT53 (PubMed:17332504). Interacts with influenza A virus PA and PB1 polymerase subunits during infection (PubMed:26202233).3 Publications
(Microbial infection) Interacts with influenza A virus PA and PB1 polymerase subunits during infection.1 Publication

Protein-protein interaction databases

BioGridi117062, 21 interactors
IntActiQ14149, 17 interactors
STRINGi9606.ENSP00000383333

Structurei

Secondary structure

1939
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ14149
SMRiQ14149
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni326 – 353Nuclear matrix binding1 PublicationAdd BLAST28
Regioni500 – 591RNA binding1 PublicationAdd BLAST92

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili686 – 877Sequence analysisAdd BLAST192

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri404 – 454CW-typePROSITE-ProRule annotationAdd BLAST51

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiKOG1845 Eukaryota
ENOG411033B LUCA
GeneTreeiENSGT00530000062983
HOGENOMiHOG000246950
HOVERGENiHBG055625
InParanoidiQ14149
OMAiAFNKHRQ
OrthoDBiEOG091G018P
PhylomeDBiQ14149
TreeFamiTF329118

Family and domain databases

CDDicd00075 HATPase_c, 1 hit
Gene3Di3.30.565.10, 1 hit
InterProiView protein in InterPro
IPR003594 HATPase_C
IPR036890 HATPase_C_sf
IPR011124 Znf_CW
PfamiView protein in Pfam
PF07496 zf-CW, 1 hit
SUPFAMiSSF55874 SSF55874, 1 hit
PROSITEiView protein in PROSITE
PS51050 ZF_CW, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q14149-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAQPPRGIR LSALCPKFLH TNSTSHTWPF SAVAELIDNA YDPDVNAKQI
60 70 80 90 100
WIDKTVINDH ICLTFTDNGN GMTSDKLHKM LSFGFSDKVT MNGHVPVGLY
110 120 130 140 150
GNGFKSGSMR LGKDAIVFTK NGESMSVGLL SQTYLEVIKA EHVVVPIVAF
160 170 180 190 200
NKHRQMINLA ESKASLAAIL EHSLFSTEQK LLAELDAIIG KKGTRIIIWN
210 220 230 240 250
LRSYKNATEF DFEKDKYDIR IPEDLDEITG KKGYKKQERM DQIAPESDYS
260 270 280 290 300
LRAYCSILYL KPRMQIILRG QKVKTQLVSK SLAYIERDVY RPKFLSKTVR
310 320 330 340 350
ITFGFNCRNK DHYGIMMYHR NRLIKAYEKV GCQLRANNMG VGVVGIIECN
360 370 380 390 400
FLKPTHNKQD FDYTNEYRLT ITALGEKLND YWNEMKVKKN TEYPLNLPVE
410 420 430 440 450
DIQKRPDQTW VQCDACLKWR KLPDGMDQLP EKWYCSNNPD PQFRNCEVPE
460 470 480 490 500
EPEDEDLVHP TYEKTYKKTN KEKFRIRQPE MIPRINAELL FRPTALSTPS
510 520 530 540 550
FSSPKESVPR RHLSEGTNSY ATRLLNNHQV PPQSEPESNS LKRRLSTRSS
560 570 580 590 600
ILNAKNRRLS SQFENSVYKG DDDDEDVIIL EENSTPKPAV DHDIDMKSEQ
610 620 630 640 650
SHVEQGGVQV EFVGDSEPCG QTGSTSTSSS RCDQGNTAAT QTEVPSLVVK
660 670 680 690 700
KEETVEDEID VRNDAVILPS CVEAEAKIHE TQETTDKSAD DAGCQLQELR
710 720 730 740 750
NQLLLVTEEK ENYKRQCHMF TDQIKVLQQR ILEMNDKYVK KETCHQSTET
760 770 780 790 800
DAVFLLESIN GKSESPDHMV SQYQQALEEI ERLKKQCSAL QHVKAECSQC
810 820 830 840 850
SNNESKSEMD EMAVQLDDVF RQLDKCSIER DQYKSEVELL EMEKSQIRSQ
860 870 880 890 900
CEELKTEVEQ LKSTNQQTAT DVSTSSNIEE SVNHMDGESL KLRSLRVNVG
910 920 930
QLLAMIVPDL DLQQVNYDVD VVDEILGQVV EQMSEISST
Length:939
Mass (Da):107,113
Last modified:June 13, 2006 - v3
Checksum:i7DF0EC31936BF5FF
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YIR5H0YIR5_HUMAN
MORC family CW-type zinc finger pro...
MORC3
226Annotation score:
H0YHQ4H0YHQ4_HUMAN
MORC family CW-type zinc finger pro...
MORC3
191Annotation score:

Sequence cautioni

The sequence BAA09485 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAA89432 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50926 mRNA Translation: BAA09485.2 Different initiation.
AK292957 mRNA Translation: BAF85646.1
AP000693, AP000692 Genomic DNA Translation: BAA89432.1 Different initiation.
CCDSiCCDS42924.1
RefSeqiNP_056173.1, NM_015358.2
UniGeneiHs.421150

Genome annotation databases

EnsembliENST00000400485; ENSP00000383333; ENSG00000159256
GeneIDi23515
KEGGihsa:23515
UCSCiuc002yvi.3 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50926 mRNA Translation: BAA09485.2 Different initiation.
AK292957 mRNA Translation: BAF85646.1
AP000693, AP000692 Genomic DNA Translation: BAA89432.1 Different initiation.
CCDSiCCDS42924.1
RefSeqiNP_056173.1, NM_015358.2
UniGeneiHs.421150

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4QQ4X-ray1.75A/B400-460[»]
5SVIX-ray1.61A407-453[»]
5SVXX-ray1.56A407-454[»]
5SVYX-ray1.05A407-455[»]
ProteinModelPortaliQ14149
SMRiQ14149
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117062, 21 interactors
IntActiQ14149, 17 interactors
STRINGi9606.ENSP00000383333

PTM databases

iPTMnetiQ14149
PhosphoSitePlusiQ14149

Polymorphism and mutation databases

BioMutaiMORC3
DMDMi108935853

Proteomic databases

EPDiQ14149
MaxQBiQ14149
PaxDbiQ14149
PeptideAtlasiQ14149
PRIDEiQ14149
ProteomicsDBi59852

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000400485; ENSP00000383333; ENSG00000159256
GeneIDi23515
KEGGihsa:23515
UCSCiuc002yvi.3 human

Organism-specific databases

CTDi23515
DisGeNETi23515
EuPathDBiHostDB:ENSG00000159256.12
GeneCardsiMORC3
HGNCiHGNC:23572 MORC3
HPAiHPA018406
HPA034848
MIMi610078 gene
neXtProtiNX_Q14149
OpenTargetsiENSG00000159256
PharmGKBiPA128394632
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1845 Eukaryota
ENOG411033B LUCA
GeneTreeiENSGT00530000062983
HOGENOMiHOG000246950
HOVERGENiHBG055625
InParanoidiQ14149
OMAiAFNKHRQ
OrthoDBiEOG091G018P
PhylomeDBiQ14149
TreeFamiTF329118

Miscellaneous databases

ChiTaRSiMORC3 human
GeneWikiiMORC3
GenomeRNAii23515
PROiPR:Q14149
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000159256 Expressed in 225 organ(s), highest expression level in corpus callosum
CleanExiHS_MORC3
ExpressionAtlasiQ14149 baseline and differential
GenevisibleiQ14149 HS

Family and domain databases

CDDicd00075 HATPase_c, 1 hit
Gene3Di3.30.565.10, 1 hit
InterProiView protein in InterPro
IPR003594 HATPase_C
IPR036890 HATPase_C_sf
IPR011124 Znf_CW
PfamiView protein in Pfam
PF07496 zf-CW, 1 hit
SUPFAMiSSF55874 SSF55874, 1 hit
PROSITEiView protein in PROSITE
PS51050 ZF_CW, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMORC3_HUMAN
AccessioniPrimary (citable) accession number: Q14149
Secondary accession number(s): A8KA92, Q9UEZ2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: June 13, 2006
Last modified: November 7, 2018
This is version 138 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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