UniProtKB - Q14149 (MORC3_HUMAN)

BLAST

>sp|Q14149|MORC3_HUMAN MORC family CW-type zinc finger protein 3 OS=Homo sapiens OX=9606 GN=MORC3 PE=1 SV=3
MAAQPPRGIRLSALCPKFLHTNSTSHTWPFSAVAELIDNAYDPDVNAKQIWIDKTVINDH
ICLTFTDNGNGMTSDKLHKMLSFGFSDKVTMNGHVPVGLYGNGFKSGSMRLGKDAIVFTK
NGESMSVGLLSQTYLEVIKAEHVVVPIVAFNKHRQMINLAESKASLAAILEHSLFSTEQK
LLAELDAIIGKKGTRIIIWNLRSYKNATEFDFEKDKYDIRIPEDLDEITGKKGYKKQERM
DQIAPESDYSLRAYCSILYLKPRMQIILRGQKVKTQLVSKSLAYIERDVYRPKFLSKTVR
ITFGFNCRNKDHYGIMMYHRNRLIKAYEKVGCQLRANNMGVGVVGIIECNFLKPTHNKQD
FDYTNEYRLTITALGEKLNDYWNEMKVKKNTEYPLNLPVEDIQKRPDQTWVQCDACLKWR
KLPDGMDQLPEKWYCSNNPDPQFRNCEVPEEPEDEDLVHPTYEKTYKKTNKEKFRIRQPE
MIPRINAELLFRPTALSTPSFSSPKESVPRRHLSEGTNSYATRLLNNHQVPPQSEPESNS
LKRRLSTRSSILNAKNRRLSSQFENSVYKGDDDDEDVIILEENSTPKPAVDHDIDMKSEQ
SHVEQGGVQVEFVGDSEPCGQTGSTSTSSSRCDQGNTAATQTEVPSLVVKKEETVEDEID
VRNDAVILPSCVEAEAKIHETQETTDKSADDAGCQLQELRNQLLLVTEEKENYKRQCHMF
TDQIKVLQQRILEMNDKYVKKETCHQSTETDAVFLLESINGKSESPDHMVSQYQQALEEI
ERLKKQCSALQHVKAECSQCSNNESKSEMDEMAVQLDDVFRQLDKCSIERDQYKSEVELL
EMEKSQIRSQCEELKTEVEQLKSTNQQTATDVSTSSNIEESVNHMDGESLKLRSLRVNVG
QLLAMIVPDLDLQQVNYDVDVVDEILGQVVEQMSEISST

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History
Entry version 138 (07 Nov 2018)
Sequence version 3 (13 Jun 2006)
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Protein

MORC family CW-type zinc finger protein 3

Gene

MORC3

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Nuclear factor which forms MORC3-NBs (nuclear bodies) via an ATP-dependent mechanism (PubMed:20501696). Sumoylated MORC3-NBs can also associate with PML-NBs (PubMed:20501696). Recruits TP53 and SP100 to PML-NBs, thus regulating TP53 activity (PubMed:17332504). Binds RNA in vitro (PubMed:11927593). May be required for influenza A transcription during viral infection (PubMed:26202233).4 Publications

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	404 – 454	CW-typePROSITE-ProRule annotationAdd BLAST		51

GO - Molecular functionⁱ

RNA binding Source: UniProtKB-KW
zinc ion binding Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell aging
Source: MGI
Inferred from direct assayⁱ
- 17332504
maintenance of protein location in nucleus
Source: MGI
Inferred from direct assayⁱ
- 17332504
negative regulation of fibroblast proliferation
Source: MGI
Inferred from direct assayⁱ
- 17332504
peptidyl-serine phosphorylation
Source: MGI
Inferred from direct assayⁱ
- 17332504
post-embryonic development Source: Ensembl
protein phosphorylation
Source: MGI
Inferred from direct assayⁱ
- 17332504
protein stabilization
Source: MGI
Inferred from direct assayⁱ
- 17332504
viral process Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	RNA-binding
Biological process	Host-virus interaction
Ligand	Metal-binding, Zinc

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: MORC family CW-type zinc finger protein 3 Alternative name(s): Nuclear matrix protein 21 Publication Zinc finger CW-type coiled-coil domain protein 3
Gene namesⁱ	Name:MORC3Imported Synonyms:KIAA0136Imported, NXP2Imported, ZCWCC3Imported
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 21

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000159256.12
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:23572 MORC3
MIMⁱ	610078 gene
neXtProtⁱ	NX_Q14149

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	35	E → A: Fails to localize to PML nuclear bodies and activate TP53. 1 Publication	1
Mutagenesisⁱ	67	D → N: Forms nuclear bodies, but rapidly diffuses throughout the nucleus under conditions of ATP depletion. 1 Publication	1
Mutagenesisⁱ	101	G → A: Diffuse nuclear localization. Fails to form nuclear bodies in the presence of ATP. 1 Publication	1
Mutagenesisⁱ	419	W → A: Diffuse nuclear localization, possibly due to loss of DNA or nucleosome binding. 1 Publication	1
Mutagenesisⁱ	597	K → R: Loss of sumoylation; when associated with R-650; R-651; R-740 and R-794. 1 Publication	1
Mutagenesisⁱ	650	K → R: Loss of sumoylation; when associated with R-597; R-651; R-740 and R-794. 1 Publication	1
Mutagenesisⁱ	651	K → R: Loss of sumoylation; when associated with R-597; R-650; R-740 and R-794. 1 Publication	1
Mutagenesisⁱ	740	K → R: Loss of sumoylation; when associated with R-597; R-650; R-651 and R-794. 1 Publication	1
Mutagenesisⁱ	794	K → R: Loss of sumoylation; when associated with R-597; R-650; R-651 and R-740. 1 Publication	1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	23515
Open Targets More...OpenTargetsⁱ	ENSG00000159256
PharmGKBⁱ	PA128394632

Polymorphism and mutation databases

BioMutaⁱ	MORC3
DMDMⁱ	108935853

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000096538	1 – 939	MORC family CW-type zinc finger protein 3Add BLAST		939

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Cross-linkⁱ	191	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	205	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	231	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	280	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	293	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	503	PhosphoserineCombined sources	1
Modified residueⁱ	514	PhosphoserineCombined sources	1
Modified residueⁱ	540	PhosphoserineCombined sources	1
Cross-linkⁱ	555	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	560	PhosphoserineCombined sources	1
Cross-linkⁱ	597	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternate1 Publication
Cross-linkⁱ	597	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Cross-linkⁱ	650	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternate1 Publication
Cross-linkⁱ	650	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Cross-linkⁱ	651	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternate1 Publication
Cross-linkⁱ	651	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Cross-linkⁱ	740	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternate1 Publication
Cross-linkⁱ	740	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residueⁱ	765	PhosphoserineCombined sources	1
Cross-linkⁱ	794	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternate1 Publication
Cross-linkⁱ	794	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Cross-linkⁱ	855	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Post-translational modificationⁱ

Sumoylation is involved in interaction with PML and localization to PML nuclear bodies.1 Publication

Keywords - PTMⁱ

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	Q14149
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q14149
PaxDbⁱ	Q14149
PeptideAtlas More...PeptideAtlasⁱ	Q14149
PRIDEⁱ	Q14149
ProteomicsDBⁱ	59852

PTM databases

iPTMnetⁱ	Q14149
PhosphoSitePlusⁱ	Q14149

Expressionⁱ

Tissue specificityⁱ

Expressed in heart, placenta, skeletal muscle, brain, pancreas, lung, liver, but not kidney.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000159256 Expressed in 225 organ(s), highest expression level in corpus callosum
CleanExⁱ	HS_MORC3
ExpressionAtlasⁱ	Q14149 baseline and differential
Genevisibleⁱ	Q14149 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA018406 HPA034848

HPAⁱ

HPA018406
HPA034848

Interactionⁱ

Subunit structureⁱ

Homodimer (PubMed:17332504). The sumoylated form interacts with PML (via SUMO-interacting motif) (PubMed:20501696, PubMed:17332504). Interacts with PT53 (PubMed:17332504). Interacts with influenza A virus PA and PB1 polymerase subunits during infection (PubMed:26202233).3 Publications

(Microbial infection) Interacts with influenza A virus PA and PB1 polymerase subunits during infection.1 Publication

Protein-protein interaction databases

BioGridⁱ	117062, 21 interactors
IntActⁱ	Q14149, 17 interactors
STRINGⁱ	9606.ENSP00000383333

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	408 – 412	Combined sources	5
Turnⁱ	414 – 416	Combined sources	3
Beta strandⁱ	419 – 422	Combined sources	4
Helixⁱ	435 – 437	Combined sources	3
Helixⁱ	441 – 443	Combined sources	3

Show more details

3D structure databases

ProteinModelPortalⁱ	Q14149
SMRⁱ	Q14149
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	326 – 353	Nuclear matrix binding1 PublicationAdd BLAST		28
Regionⁱ	500 – 591	RNA binding1 PublicationAdd BLAST		92

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	686 – 877	Sequence analysisAdd BLAST		192

Zinc finger

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	404 – 454	CW-typePROSITE-ProRule annotationAdd BLAST		51

Keywords - Domainⁱ

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG1845 Eukaryota ENOG411033B LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000062983
HOGENOMⁱ	HOG000246950
HOVERGENⁱ	HBG055625
InParanoidⁱ	Q14149
OMAⁱ	AFNKHRQ
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G018P
PhylomeDBⁱ	Q14149
TreeFamⁱ	TF329118

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00075 HATPase_c, 1 hit
Gene3Dⁱ	3.30.565.10, 1 hit
InterProⁱ	View protein in InterPro IPR003594 HATPase_C IPR036890 HATPase_C_sf IPR011124 Znf_CW
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF07496 zf-CW, 1 hit
SUPFAMⁱ	SSF55874 SSF55874, 1 hit
PROSITEⁱ	View protein in PROSITE PS51050 ZF_CW, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show all Align All

Q14149-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAAQPPRGIR LSALCPKFLH TNSTSHTWPF SAVAELIDNA YDPDVNAKQI 
        60         70         80         90        100
WIDKTVINDH ICLTFTDNGN GMTSDKLHKM LSFGFSDKVT MNGHVPVGLY 
       110        120        130        140        150
GNGFKSGSMR LGKDAIVFTK NGESMSVGLL SQTYLEVIKA EHVVVPIVAF 
       160        170        180        190        200
NKHRQMINLA ESKASLAAIL EHSLFSTEQK LLAELDAIIG KKGTRIIIWN 
       210        220        230        240        250
LRSYKNATEF DFEKDKYDIR IPEDLDEITG KKGYKKQERM DQIAPESDYS 
       260        270        280        290        300
LRAYCSILYL KPRMQIILRG QKVKTQLVSK SLAYIERDVY RPKFLSKTVR 
       310        320        330        340        350
ITFGFNCRNK DHYGIMMYHR NRLIKAYEKV GCQLRANNMG VGVVGIIECN 
       360        370        380        390        400
FLKPTHNKQD FDYTNEYRLT ITALGEKLND YWNEMKVKKN TEYPLNLPVE 
       410        420        430        440        450
DIQKRPDQTW VQCDACLKWR KLPDGMDQLP EKWYCSNNPD PQFRNCEVPE 
       460        470        480        490        500
EPEDEDLVHP TYEKTYKKTN KEKFRIRQPE MIPRINAELL FRPTALSTPS 
       510        520        530        540        550
FSSPKESVPR RHLSEGTNSY ATRLLNNHQV PPQSEPESNS LKRRLSTRSS 
       560        570        580        590        600
ILNAKNRRLS SQFENSVYKG DDDDEDVIIL EENSTPKPAV DHDIDMKSEQ 
       610        620        630        640        650
SHVEQGGVQV EFVGDSEPCG QTGSTSTSSS RCDQGNTAAT QTEVPSLVVK 
       660        670        680        690        700
KEETVEDEID VRNDAVILPS CVEAEAKIHE TQETTDKSAD DAGCQLQELR 
       710        720        730        740        750
NQLLLVTEEK ENYKRQCHMF TDQIKVLQQR ILEMNDKYVK KETCHQSTET 
       760        770        780        790        800
DAVFLLESIN GKSESPDHMV SQYQQALEEI ERLKKQCSAL QHVKAECSQC 
       810        820        830        840        850
SNNESKSEMD EMAVQLDDVF RQLDKCSIER DQYKSEVELL EMEKSQIRSQ 
       860        870        880        890        900
CEELKTEVEQ LKSTNQQTAT DVSTSSNIEE SVNHMDGESL KLRSLRVNVG 
       910        920        930 
QLLAMIVPDL DLQQVNYDVD VVDEILGQVV EQMSEISST

Length:939

Mass (Da):107,113

Last modified:June 13, 2006 - v3

Checksum:ⁱ7DF0EC31936BF5FF

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

H0YIR5	H0YIR5_HUMAN	MORC family CW-type zinc finger pro... MORC family CW-type zinc finger protein 3	MORC3	226	Annotation score:
H0YHQ4	H0YHQ4_HUMAN	MORC family CW-type zinc finger pro... MORC family CW-type zinc finger protein 3	MORC3	191	Annotation score:

Sequence cautionⁱ

The sequence BAA09485 differs from that shown. Reason: Erroneous initiation.Curated

The sequence BAA89432 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	D50926 mRNA Translation: BAA09485.2 Different initiation. AK292957 mRNA Translation: BAF85646.1 AP000693, AP000692 Genomic DNA Translation: BAA89432.1 Different initiation.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS42924.1
NCBI Reference Sequences More...RefSeqⁱ	NP_056173.1, NM_015358.2
UniGeneⁱ	Hs.421150

Genome annotation databases

Ensemblⁱ	ENST00000400485; ENSP00000383333; ENSG00000159256
GeneIDⁱ	23515
KEGGⁱ	hsa:23515
UCSC genome browser More...UCSCⁱ	uc002yvi.3 human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q14149	cDNA FLJ57931, highly similar to MORC family CW-type zinc finger 3		HUMAN		868	UniRef100_Q14149
MORC3 isoform 10 (Fragment)		PANTR		191
MORC3 protein (Fragment)		HUMAN		250
MORC family CW-type zinc finger protein 3		HUMAN		191
UPI0000206E47		HUMAN		555

Protein	Similar proteins		Species	Score	Length	Source
Q14149	cDNA FLJ57931, highly similar to MORC family CW-type zinc finger 3		HUMAN		868	UniRef90_Q14149
MORC3 isoform 10 (Fragment)		PANTR		191
MORC family CW-type zinc finger 3		AILME		990
MORC family CW-type zinc finger protein 3		URSMA		962
Uncharacterized protein		MACMU		941
+79

Protein	Similar proteins		Species	Score	Length	Source
Q14149	MORC family CW-type zinc finger protein 3	)	MOUSE		942	UniRef50_Q14149
cDNA FLJ57931, highly similar to MORC family CW-type zinc finger 3		HUMAN		868
MORC3 isoform 10 (Fragment)		PANTR		191
MORC family CW-type zinc finger 3		AILME		990
MORC family CW-type zinc finger protein 3		URSMA		962
+356

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	D50926 mRNA Translation: BAA09485.2 Different initiation. AK292957 mRNA Translation: BAF85646.1 AP000693, AP000692 Genomic DNA Translation: BAA89432.1 Different initiation.
CCDSⁱ	CCDS42924.1
RefSeqⁱ	NP_056173.1, NM_015358.2
UniGeneⁱ	Hs.421150

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	4QQ4	X-ray	1.75	A/B	400-460	[»]
	5SVI	X-ray	1.61	A	407-453	[»]
	5SVX	X-ray	1.56	A	407-454	[»]
	5SVY	X-ray	1.05	A	407-455	[»]
ProteinModelPortalⁱ	Q14149
SMRⁱ	Q14149
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	117062, 21 interactors
IntActⁱ	Q14149, 17 interactors
STRINGⁱ	9606.ENSP00000383333

PTM databases

iPTMnetⁱ	Q14149
PhosphoSitePlusⁱ	Q14149

Polymorphism and mutation databases

BioMutaⁱ	MORC3
DMDMⁱ	108935853

Proteomic databases

EPDⁱ	Q14149
MaxQBⁱ	Q14149
PaxDbⁱ	Q14149
PeptideAtlasⁱ	Q14149
PRIDEⁱ	Q14149
ProteomicsDBⁱ	59852

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000400485; ENSP00000383333; ENSG00000159256
GeneIDⁱ	23515
KEGGⁱ	hsa:23515
UCSCⁱ	uc002yvi.3 human

Organism-specific databases

CTDⁱ	23515
DisGeNETⁱ	23515
EuPathDBⁱ	HostDB:ENSG00000159256.12
GeneCardsⁱ	MORC3
HGNCⁱ	HGNC:23572 MORC3
HPAⁱ	HPA018406 HPA034848
MIMⁱ	610078 gene
neXtProtⁱ	NX_Q14149
OpenTargetsⁱ	ENSG00000159256
PharmGKBⁱ	PA128394632
HUGEⁱ	Search...
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1845 Eukaryota ENOG411033B LUCA
GeneTreeⁱ	ENSGT00530000062983
HOGENOMⁱ	HOG000246950
HOVERGENⁱ	HBG055625
InParanoidⁱ	Q14149
OMAⁱ	AFNKHRQ
OrthoDBⁱ	EOG091G018P
PhylomeDBⁱ	Q14149
TreeFamⁱ	TF329118

Miscellaneous databases

ChiTaRSⁱ	MORC3 human
GeneWikiⁱ	MORC3
GenomeRNAiⁱ	23515
Protein Ontology More...PROⁱ	PR:Q14149
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000159256 Expressed in 225 organ(s), highest expression level in corpus callosum
CleanExⁱ	HS_MORC3
ExpressionAtlasⁱ	Q14149 baseline and differential
Genevisibleⁱ	Q14149 HS

Family and domain databases

CDDⁱ	cd00075 HATPase_c, 1 hit
Gene3Dⁱ	3.30.565.10, 1 hit
InterProⁱ	View protein in InterPro IPR003594 HATPase_C IPR036890 HATPase_C_sf IPR011124 Znf_CW
Pfamⁱ	View protein in Pfam PF07496 zf-CW, 1 hit
SUPFAMⁱ	SSF55874 SSF55874, 1 hit
PROSITEⁱ	View protein in PROSITE PS51050 ZF_CW, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	MORC3_HUMAN
Accessionⁱ	Q14149Primary (citable) accession number: Q14149 Secondary accession number(s): A8KA92, Q9UEZ2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
	Last sequence update:	June 13, 2006
	Last modified:	November 7, 2018
	This is version 138 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 21
Human chromosome 21: entries, gene names and cross-references to MIM
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q14149 (MORC3_HUMAN)

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MORC family CW-type zinc finger protein 3

MORC3

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Coiled coil

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ