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Protein

Unhealthy ribosome biogenesis protein 2 homolog

Gene

URB2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • ribosome biogenesis Source: GO_Central

Names & Taxonomyi

Protein namesi
Recommended name:
Unhealthy ribosome biogenesis protein 2 homolog
Gene namesi
Name:URB2
Synonyms:KIAA0133
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000135763.9
HGNCiHGNC:28967 URB2
neXtProtiNX_Q14146

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000135763
PharmGKBiPA164727496

Polymorphism and mutation databases

BioMutaiURB2
DMDMi209572635

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000507201 – 1524Unhealthy ribosome biogenesis protein 2 homologAdd BLAST1524

Proteomic databases

EPDiQ14146
MaxQBiQ14146
PaxDbiQ14146
PeptideAtlasiQ14146
PRIDEiQ14146
ProteomicsDBi59850

PTM databases

CarbonylDBiQ14146
iPTMnetiQ14146
PhosphoSitePlusiQ14146

Expressioni

Gene expression databases

BgeeiENSG00000135763 Expressed in 154 organ(s), highest expression level in pituitary gland
CleanExiHS_URB2
ExpressionAtlasiQ14146 baseline and differential
GenevisibleiQ14146 HS

Organism-specific databases

HPAiHPA008902
HPA046788

Interactioni

Protein-protein interaction databases

BioGridi115155, 29 interactors
IntActiQ14146, 8 interactors

Structurei

3D structure databases

ProteinModelPortaliQ14146
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IHVN Eukaryota
ENOG410ZP2S LUCA
GeneTreeiENSGT00390000009258
HOGENOMiHOG000154789
HOVERGENiHBG107151
InParanoidiQ14146
KOiK14862
OMAiILQCHPK
OrthoDBiEOG091G00DX
PhylomeDBiQ14146
TreeFamiTF328770

Family and domain databases

InterProiView protein in InterPro
IPR018849 Urb2/Npa2_C
PfamiView protein in Pfam
PF10441 Urb2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q14146-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAVYSGISL KLKSKTTSWE DKLKLAHFAW ISHQCFLPNK EQVLLDWARQ
60 70 80 90 100
SLVAFYKKKL ELKEDIVERL WIYIDNILHS RKLQNLLKNG KTINLQISLV
110 120 130 140 150
KIINERVAEF SLSGSQRNIC AVLRCCQGIL STPALAVIYT AKQELMVALL
160 170 180 190 200
SQLCWSACRQ PEGAVVAQLF EVIHLALGHY LLILQQQVNP RRAFGDVTAH
210 220 230 240 250
LLQPCLVLRH LLSGGTWTQA GQGQLRQVLS RDIRSQIEAM FRGGIFQPEL
260 270 280 290 300
LSSYKEGLLD QQQGDVKTGA MKNLLAPMDT VLNRLVDAGY CAASLHTSVV
310 320 330 340 350
ANSVALLYKL FLDSYFKEGN QLLCFQVLPR LFGCLKISHL QEEQSKALST
360 370 380 390 400
SDWTTELLVV EQLLNSVANN NIYNIAADRI RHEEAQFRFY RHVAELLINH
410 420 430 440 450
AQAPIPAWFR CLKTLISLNH LILEPDLDDL LASAWIDAEV TEFRTKKAQE
460 470 480 490 500
ALIRTVFQTY AKLRQVPRLF EEVLGVICRP AAEALRQPVL ASGPSTVLSA
510 520 530 540 550
CLLELPPSQI LDTWSLVLEK FQSLVLPYLQ SDADMALKSL SLSLLLHCIM
560 570 580 590 600
FNMRSLDSST PLPIVRRTQC MMERMMRELV QPLLALLPDT PGPEPELWLQ
610 620 630 640 650
KVSDSVLLLS YTWAQVDAMF SLNCSQYHSM SGPLIGVALE ISNLPSLLPG
660 670 680 690 700
VKTQHWKKIE KFTAQFSSLG TYCLEQLYLQ KMKRTLMQTS FRSEGAIQSL
710 720 730 740 750
RCDAAFIIGS GRKSLNQRTT ASWDGQVGMV SGLTYPVAHW HLIVSNLTIL
760 770 780 790 800
ISYLCPDDVG YLASVLLRTL PMGKAQEVSI DEEAYITLEK ISKAFLHSPL
810 820 830 840 850
FPEMQSLHSA FLTCVTTSCS SILCSGAQRD SGLVSQQLPW LFEKDHMVVG
860 870 880 890 900
HWENRFAKAG PEGIEPRGEI AQNLLSLVKS DFPIQLEGEQ LESILGLLEV
910 920 930 940 950
ISALQLDSLL PPYHVHYFLV LLSMAVTKLG CSCSSSLALK FLTTCYQLLG
960 970 980 990 1000
YLQKGKSARS VFKIMYGSDI FEVVLTSLFR ASSRFLIEMD DPAWLEFLQV
1010 1020 1030 1040 1050
IGTFLEELMQ MLIQMKLSLV LNFRKITAFL SSSKPYTEAA SSKQLENQNP
1060 1070 1080 1090 1100
QGRQLLLVSL TRLCHVLGPF LKEQKLGQEA PAALSELLQQ VVLQTGAVLQ
1110 1120 1130 1140 1150
LCSVPGARGW RLPSVLISSV STLLEADLGQ HCRDGGADIS QGSDRTLLSH
1160 1170 1180 1190 1200
VALYQGVYSQ ILLELPALAG HDQSFQAALQ FLTLFFLAPE LHPKKDSVFT
1210 1220 1230 1240 1250
SMFHSVRRVL ADPEIPVQVT QDIEPHLGAL FTQMLEVGTT EDLRLVMQCI
1260 1270 1280 1290 1300
LQGLDVSNMW KADVQAVVSA VTLLRLLLNC PLSGEKASLL WRACPQIVTA
1310 1320 1330 1340 1350
LTLLNREASQ EQPVSLTVVG PVLDVLAALL RQGEEAIGNP HHVSLAFSIL
1360 1370 1380 1390 1400
LTVPLDHLKP LEYGSVFPRL HNVLFSILQC HPKVMLKAIP SFLNSFNRLV
1410 1420 1430 1440 1450
FSVMREGRQK DKGSIDDLPT VLKCARLVER MYSHIAARAE EFAVFSPFMV
1460 1470 1480 1490 1500
AQYVLEVQKV TLYPAVKSLL QEGIYLILDL CIEPDVQFLR ASLQPGMRDI
1510 1520
FKELYNDYLK YHKAKHEGEK RYTA
Length:1,524
Mass (Da):170,544
Last modified:October 14, 2008 - v2
Checksum:iD27CFF42B0892679
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5VYD0Q5VYD0_HUMAN
Unhealthy ribosome biogenesis prote...
URB2
84Annotation score:

Sequence cautioni

The sequence BAA09482 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_034031778V → G. Corresponds to variant dbSNP:rs3811473Ensembl.1
Natural variantiVAR_0469751400V → M. Corresponds to variant dbSNP:rs12142450Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50923 mRNA Translation: BAA09482.3 Different initiation.
AL354983 Genomic DNA No translation available.
AL121990 Genomic DNA No translation available.
BC114559 mRNA Translation: AAI14560.1
BC114963 mRNA Translation: AAI14964.1
CCDSiCCDS31052.1
RefSeqiNP_001300950.1, NM_001314021.1
NP_055592.2, NM_014777.3
UniGeneiHs.533628

Genome annotation databases

EnsembliENST00000258243; ENSP00000258243; ENSG00000135763
GeneIDi9816
KEGGihsa:9816
UCSCiuc001hts.1 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50923 mRNA Translation: BAA09482.3 Different initiation.
AL354983 Genomic DNA No translation available.
AL121990 Genomic DNA No translation available.
BC114559 mRNA Translation: AAI14560.1
BC114963 mRNA Translation: AAI14964.1
CCDSiCCDS31052.1
RefSeqiNP_001300950.1, NM_001314021.1
NP_055592.2, NM_014777.3
UniGeneiHs.533628

3D structure databases

ProteinModelPortaliQ14146
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115155, 29 interactors
IntActiQ14146, 8 interactors

PTM databases

CarbonylDBiQ14146
iPTMnetiQ14146
PhosphoSitePlusiQ14146

Polymorphism and mutation databases

BioMutaiURB2
DMDMi209572635

Proteomic databases

EPDiQ14146
MaxQBiQ14146
PaxDbiQ14146
PeptideAtlasiQ14146
PRIDEiQ14146
ProteomicsDBi59850

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000258243; ENSP00000258243; ENSG00000135763
GeneIDi9816
KEGGihsa:9816
UCSCiuc001hts.1 human

Organism-specific databases

CTDi9816
EuPathDBiHostDB:ENSG00000135763.9
GeneCardsiURB2
HGNCiHGNC:28967 URB2
HPAiHPA008902
HPA046788
neXtProtiNX_Q14146
OpenTargetsiENSG00000135763
PharmGKBiPA164727496
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHVN Eukaryota
ENOG410ZP2S LUCA
GeneTreeiENSGT00390000009258
HOGENOMiHOG000154789
HOVERGENiHBG107151
InParanoidiQ14146
KOiK14862
OMAiILQCHPK
OrthoDBiEOG091G00DX
PhylomeDBiQ14146
TreeFamiTF328770

Miscellaneous databases

ChiTaRSiURB2 human
GenomeRNAii9816
PROiPR:Q14146

Gene expression databases

BgeeiENSG00000135763 Expressed in 154 organ(s), highest expression level in pituitary gland
CleanExiHS_URB2
ExpressionAtlasiQ14146 baseline and differential
GenevisibleiQ14146 HS

Family and domain databases

InterProiView protein in InterPro
IPR018849 Urb2/Npa2_C
PfamiView protein in Pfam
PF10441 Urb2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiURB2_HUMAN
AccessioniPrimary (citable) accession number: Q14146
Secondary accession number(s): Q5VYC9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: October 14, 2008
Last modified: November 7, 2018
This is version 131 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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