KEAP1

Functionⁱ

Acts as a substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1 and targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. Retains NFE2L2/NRF2 and may also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome.5 Publications

Activity regulationⁱ

Ubiquitination and subsequent degradation of PGAM5 is inhibited by oxidative stress and sulforaphane. Sulforaphane also inhibits ubiquitination of NFE2L2/NRF2.2 Publications

Pathwayⁱ: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functionⁱ

disordered domain specific binding Source: Ensembl
protein homodimerization activity Source: Ensembl
transcription factor binding
Source: ParkinsonsUK-UCL
Inferred from physical interactionⁱ
- 17015834

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cellular response to interleukin-4 Source: Ensembl
cytoplasmic sequestering of transcription factor Source: GO_Central
in utero embryonic development Source: Ensembl
negative regulation of DNA-binding transcription factor activity
Source: ParkinsonsUK-UCL
Traceable author statementⁱ
- 17015834
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
Source: ParkinsonsUK-UCL
Traceable author statementⁱ
- 17015834
post-translational protein modification Source: Reactome
proteasomal ubiquitin-independent protein catabolic process
Source: UniProtKB
Inferred from direct assayⁱ
- 15983046
protein deubiquitination Source: Reactome
protein ubiquitination
Source: UniProtKB
Inferred from direct assayⁱ
- 15983046
regulation of epidermal cell differentiation Source: Ensembl
transcription, DNA-templated Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Transcription, Transcription regulation, Ubl conjugation pathway

Biological process

Transcription, Transcription regulation, Ubl conjugation pathway

Enzyme and pathway databases

Reactomeⁱ	R-HSA-5689880 Ub-specific processing proteases R-HSA-8951664 Neddylation R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation
SIGNORⁱ	Q14145
UniPathwayⁱ	UPA00143

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Kelch-like ECH-associated protein 1 Alternative name(s): Cytosolic inhibitor of Nrf2 Short name: INrf2 Kelch-like protein 19
Gene namesⁱ	Name:KEAP1 Synonyms:INRF2, KIAA0132, KLHL19
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 19

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000079999.13
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:23177 KEAP1
MIMⁱ	606016 gene
neXtProtⁱ	NX_Q14145

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	125 – 127	IEG → AAA: Increases ubiquitination and proteolytic degradation. 1 Publication	3
Mutagenesisⁱ	151	C → S: Constitutive repression of NFE2L2-dependent gene expression. Promotes increased degradation of NFE2L2. Resistance of ubiquitination of PGAM5 to inhibition by oxidative stress and sulforaphane. Does not prevent its ubiquitination and degradation in response to quinone-induced oxidative stress. 3 Publications	1
Mutagenesisⁱ	162 – 164	YQI → AAA: Increases ubiquitination and proteolytic degradation. 1 Publication	3
Mutagenesisⁱ	273	C → S: Abolishes repression of NFE2L2-dependent gene expression. Slows down degradation of NFE2L2. 1 Publication	1
Mutagenesisⁱ	288	C → S: Abolishes repression of NFE2L2-dependent gene expression. Slows down degradation of NFE2L2. 1 Publication	1
Mutagenesisⁱ	308	L → A: Loss of export from nucleus; when associated with A-310. 1 Publication	1
Mutagenesisⁱ	310	L → A: Loss of export from nucleus; when associated with A-308. 1 Publication	1
Mutagenesisⁱ	334	Y → A: Loss of interaction with NFE2L2. Strongly reduces repression of NFE2L2-dependent gene expression. Loss of interaction with PGAM5. 2 Publications	1
Mutagenesisⁱ	380	R → A: Loss of interaction with NFE2L2. Abolishes repression of NFE2L2-dependent gene expression. 1 Publication	1
Mutagenesisⁱ	382	N → A: Loss of interaction with NFE2L2. Strongly reduces repression of NFE2L2-dependent gene expression. 1 Publication	1
Mutagenesisⁱ	415	R → A: Loss of interaction with NFE2L2. Abolishes repression of NFE2L2-dependent gene expression. Loss of interaction with PGAM5. 2 Publications	1
Mutagenesisⁱ	436	H → A: Loss of interaction with NFE2L2. Abolishes repression of NFE2L2-dependent gene expression. 1 Publication	1
Mutagenesisⁱ	478	F → A: Abolishes repression of NFE2L2-dependent gene expression. 1 Publication	1
Mutagenesisⁱ	483	R → A: Loss of interaction with NFE2L2. Abolishes repression of NFE2L2-dependent gene expression. Loss of interaction with PGAM5. 2 Publications	1
Mutagenesisⁱ	525	Y → A: Loss of interaction with NFE2L2. Strongly reduces repression of NFE2L2-dependent gene expression. 1 Publication	1
Mutagenesisⁱ	572	Y → A: Loss of interaction with NFE2L2. Strongly reduces repression of NFE2L2-dependent gene expression. Loss of interaction with PGAM5. 2 Publications	1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	9817
MalaCards human disease database More...MalaCardsⁱ	KEAP1
Open Targets More...OpenTargetsⁱ	ENSG00000079999
PharmGKBⁱ	PA134887774

Chemistry databases

ChEMBLⁱ	CHEMBL2069156
Drug and drug target database More...DrugBankⁱ	DB08908 Dimethyl fumarate
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	2757

Polymorphism and mutation databases

BioMutaⁱ	KEAP1
DMDMⁱ	146345444

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000119093	1 – 624	Kelch-like ECH-associated protein 1Add BLAST		624

Post-translational modificationⁱ

Ubiquitinated by the E3 ubiquitin ligase complex formed by CUL3 and RBX1 and is subject to proteasomal-independent degradation. Quinone-induced oxidative stress, but not sulforaphane, increases its ubiquitination. Ubiquitination and subsequent degradation is most pronounced following prolonged exposure of cells to oxidative stress, particularly in glutathione-deficient cells that are highly susceptible to oxidative stress.2 Publications

Keywords - PTMⁱ

Ubl conjugation

Proteomic databases

EPDⁱ	Q14145
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q14145
PaxDbⁱ	Q14145
PeptideAtlas More...PeptideAtlasⁱ	Q14145
PRIDEⁱ	Q14145
ProteomicsDBⁱ	59849

PTM databases

iPTMnetⁱ	Q14145
PhosphoSitePlusⁱ	Q14145

Expressionⁱ

Tissue specificityⁱ

Broadly expressed, with highest levels in skeletal muscle.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000079999 Expressed in 229 organ(s), highest expression level in muscle of leg
CleanExⁱ	HS_KEAP1
ExpressionAtlasⁱ	Q14145 baseline and differential
Genevisibleⁱ	Q14145 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB025337 HPA005558

HPAⁱ

CAB025337
HPA005558

Interactionⁱ

Subunit structureⁱ

Homodimer. Forms a ternary complex with NFE2L2 and PGAM5. Interacts with the N-terminal regulatory domain of NFE2L2/NRF2. Interacts with BPTF and PTMA. Interacts with CUL3. Part of a complex that contains KEAP1, CUL3 and RBX1. Interacts with NFE2L1 and MAP1LC3B. Interacts indirectly with ENC1. Interacts with SESN1 and SESN2 (PubMed:23274085). Interacts with HSP90AA1 and HSP90AB1 (PubMed:26517842).12 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
AMER1	Q5JTC6	2	EBI-751001,EBI-6169747
ASPA	P45381	4	EBI-751001,EBI-750475
ATG5	A9UGY9	3	EBI-751001,EBI-10175276
CCNB1IP1	Q9NPC3	3	EBI-751001,EBI-745269
DPP3	Q9NY33	7	EBI-751001,EBI-718333
ETF1	P62495	7	EBI-751001,EBI-750990
FAM117B	Q6P1L5	5	EBI-751001,EBI-3893327
GPErik	Q14440	3	EBI-751001,EBI-10232920
GYPA	A0A0C4DFT7	3	EBI-751001,EBI-12044847
GYPA	B8Q183	4	EBI-751001,EBI-10176190
IKBKB	O14920	6	EBI-751001,EBI-81266
Ikbkb	O88351	2	EBI-751001,EBI-447960	From Mus musculus.
Irf1	P15314	2	EBI-751001,EBI-6115486	From Mus musculus.
KLHL3	Q8N4I8	3	EBI-751001,EBI-10230467
LSM3	P62310	5	EBI-751001,EBI-348239
MAD2L1	Q13257	6	EBI-751001,EBI-78203
MAPKBP1	O60336	3	EBI-751001,EBI-947402
NFE2L2	Q16236	22	EBI-751001,EBI-2007911
NUDT4	Q9NZJ9	3	EBI-751001,EBI-4280066
OXR1	Q8N573-5	3	EBI-751001,EBI-10265887
PALB2	Q86YC2	3	EBI-751001,EBI-1222653
PRKAG1	P54619	5	EBI-751001,EBI-1181439
PTMA	P06454-2	5	EBI-751001,EBI-10194874
RECK	Q6P9E2	5	EBI-751001,EBI-10253121
RELA	Q04206	4	EBI-751001,EBI-73886
SESN2	P58004	3	EBI-751001,EBI-3939642
SQSTM1	Q13501	16	EBI-751001,EBI-307104
Sqstm1	Q64337	2	EBI-751001,EBI-645025	From Mus musculus.
TERF1	P54274	2	EBI-751001,EBI-710997
TSC22D4	Q9Y3Q8	3	EBI-751001,EBI-739485
WDR83	Q9BRX9	5	EBI-751001,EBI-7705033
ZSCAN32	I3L3J2	3	EBI-751001,EBI-10178206

GO - Molecular functionⁱ

disordered domain specific binding Source: Ensembl
protein homodimerization activity Source: Ensembl
transcription factor binding
Source: ParkinsonsUK-UCL
Inferred from physical interactionⁱ
- 17015834

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	115156, 132 interactors
CORUMⁱ	Q14145
Database of interacting proteins More...DIPⁱ	DIP-42134N
ELMⁱ	Q14145
IntActⁱ	Q14145, 125 interactors
Molecular INTeraction database More...MINTⁱ	Q14145
STRINGⁱ	9606.ENSP00000171111

Chemistry databases

BindingDBⁱ

Q14145

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	59 – 72	Combined sources	14
Beta strandⁱ	79 – 83	Combined sources	5
Beta strandⁱ	86 – 88	Combined sources	3
Beta strandⁱ	91 – 95	Combined sources	5
Helixⁱ	97 – 103	Combined sources	7
Helixⁱ	105 – 111	Combined sources	7
Beta strandⁱ	121 – 125	Combined sources	5
Helixⁱ	130 – 142	Combined sources	13
Helixⁱ	149 – 151	Combined sources	3
Helixⁱ	152 – 161	Combined sources	10
Helixⁱ	165 – 177	Combined sources	13
Turnⁱ	181 – 183	Combined sources	3
Helixⁱ	184 – 194	Combined sources	11
Helixⁱ	199 – 202	Combined sources	4
Beta strandⁱ	327 – 331	Combined sources	5
Beta strandⁱ	334 – 338	Combined sources	5
Beta strandⁱ	342 – 345	Combined sources	4
Turnⁱ	347 – 349	Combined sources	3
Beta strandⁱ	352 – 354	Combined sources	3
Beta strandⁱ	362 – 364	Combined sources	3
Beta strandⁱ	366 – 370	Combined sources	5
Beta strandⁱ	373 – 377	Combined sources	5
Beta strandⁱ	380 – 383	Combined sources	4
Beta strandⁱ	386 – 389	Combined sources	4
Beta strandⁱ	393 – 396	Combined sources	4
Turnⁱ	398 – 400	Combined sources	3
Beta strandⁱ	403 – 405	Combined sources	3
Beta strandⁱ	417 – 421	Combined sources	5
Beta strandⁱ	424 – 428	Combined sources	5
Beta strandⁱ	440 – 444	Combined sources	5
Turnⁱ	445 – 448	Combined sources	4
Beta strandⁱ	449 – 452	Combined sources	4
Beta strandⁱ	464 – 468	Combined sources	5
Beta strandⁱ	471 – 475	Combined sources	5
Beta strandⁱ	480 – 483	Combined sources	4
Beta strandⁱ	487 – 491	Combined sources	5
Turnⁱ	492 – 495	Combined sources	4
Beta strandⁱ	496 – 499	Combined sources	4
Beta strandⁱ	511 – 515	Combined sources	5
Beta strandⁱ	518 – 522	Combined sources	5
Beta strandⁱ	527 – 530	Combined sources	4
Beta strandⁱ	534 – 538	Combined sources	5
Turnⁱ	539 – 542	Combined sources	4
Beta strandⁱ	543 – 547	Combined sources	5
Beta strandⁱ	558 – 562	Combined sources	5
Beta strandⁱ	565 – 569	Combined sources	5
Beta strandⁱ	574 – 577	Combined sources	4
Beta strandⁱ	580 – 585	Combined sources	6
Turnⁱ	586 – 589	Combined sources	4
Beta strandⁱ	590 – 596	Combined sources	7
Beta strandⁱ	605 – 609	Combined sources	5

Show more details

3D structure databases

ProteinModelPortalⁱ	Q14145
SMRⁱ	Q14145
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q14145

EvolutionaryTraceⁱ

Q14145

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	77 – 149	BTBPROSITE-ProRule annotationAdd BLAST	73
Domainⁱ	184 – 286	BACKAdd BLAST	103
Repeatⁱ	327 – 372	Kelch 1Add BLAST	46
Repeatⁱ	373 – 423	Kelch 2Add BLAST	51
Repeatⁱ	424 – 470	Kelch 3Add BLAST	47
Repeatⁱ	471 – 517	Kelch 4Add BLAST	47
Repeatⁱ	518 – 564	Kelch 5Add BLAST	47
Repeatⁱ	565 – 611	Kelch 6Add BLAST	47

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	301 – 310	Nuclear export signal		10

Domainⁱ

The Kelch repeats mediate interaction with NF2L2/NRF2, BPTF and PGAM5.1 Publication

Keywords - Domainⁱ

Kelch repeat, Repeat

Phylogenomic databases

eggNOGⁱ	KOG4441 Eukaryota ENOG410XNX8 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118931
HOGENOMⁱ	HOG000230814
HOVERGENⁱ	HBG014286
InParanoidⁱ	Q14145
KEGG Orthology (KO) More...KOⁱ	K10456
OMAⁱ	EQIGCTE
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G02T3
PhylomeDBⁱ	Q14145
TreeFamⁱ	TF329218

Family and domain databases

Gene3Dⁱ	2.120.10.80, 1 hit
InterProⁱ	View protein in InterPro IPR011705 BACK IPR017096 BTB-kelch_protein IPR000210 BTB/POZ_dom IPR030563 KEAP1 IPR015915 Kelch-typ_b-propeller IPR006652 Kelch_1 IPR011333 SKP1/BTB/POZ_sf
PANTHERⁱ	PTHR24412:SF162 PTHR24412:SF162, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF07707 BACK, 1 hit PF00651 BTB, 1 hit PF01344 Kelch_1, 6 hits
PIRSFⁱ	PIRSF037037 Kelch-like_protein_gigaxonin, 1 hit
SMARTⁱ	View protein in SMART SM00875 BACK, 1 hit SM00225 BTB, 1 hit SM00612 Kelch, 6 hits
SUPFAMⁱ	SSF117281 SSF117281, 1 hit SSF54695 SSF54695, 1 hit
PROSITEⁱ	View protein in PROSITE PS50097 BTB, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show all Align All

Q14145-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MQPDPRPSGA GACCRFLPLQ SQCPEGAGDA VMYASTECKA EVTPSQHGNR 
        60         70         80         90        100
TFSYTLEDHT KQAFGIMNEL RLSQQLCDVT LQVKYQDAPA AQFMAHKVVL 
       110        120        130        140        150
ASSSPVFKAM FTNGLREQGM EVVSIEGIHP KVMERLIEFA YTASISMGEK 
       160        170        180        190        200
CVLHVMNGAV MYQIDSVVRA CSDFLVQQLD PSNAIGIANF AEQIGCVELH 
       210        220        230        240        250
QRAREYIYMH FGEVAKQEEF FNLSHCQLVT LISRDDLNVR CESEVFHACI 
       260        270        280        290        300
NWVKYDCEQR RFYVQALLRA VRCHSLTPNF LQMQLQKCEI LQSDSRCKDY 
       310        320        330        340        350
LVKIFEELTL HKPTQVMPCR APKVGRLIYT AGGYFRQSLS YLEAYNPSDG 
       360        370        380        390        400
TWLRLADLQV PRSGLAGCVV GGLLYAVGGR NNSPDGNTDS SALDCYNPMT 
       410        420        430        440        450
NQWSPCAPMS VPRNRIGVGV IDGHIYAVGG SHGCIHHNSV ERYEPERDEW 
       460        470        480        490        500
HLVAPMLTRR IGVGVAVLNR LLYAVGGFDG TNRLNSAECY YPERNEWRMI 
       510        520        530        540        550
TAMNTIRSGA GVCVLHNCIY AAGGYDGQDQ LNSVERYDVE TETWTFVAPM 
       560        570        580        590        600
KHRRSALGIT VHQGRIYVLG GYDGHTFLDS VECYDPDTDT WSEVTRMTSG 
       610        620 
RSGVGVAVTM EPCRKQIDQQ NCTC

Length:624

Mass (Da):69,666

Last modified:May 1, 2007 - v2

Checksum:ⁱCE180F3897BB8C97

GO

Computationally mapped potential isoform sequencesⁱ

There are 6 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

K7EJ49	K7EJ49_HUMAN	Kelch-like ECH-associated protein 1 Kelch-like ECH-associated protein 1	KEAP1	212	Annotation score:
K7EJD8	K7EJD8_HUMAN	Kelch-like ECH-associated protein 1 Kelch-like ECH-associated protein 1	KEAP1	213	Annotation score:
K7ESE0	K7ESE0_HUMAN	Kelch-like ECH-associated protein 1 Kelch-like ECH-associated protein 1	KEAP1	279	Annotation score:
K7EQX2	K7EQX2_HUMAN	Kelch-like ECH-associated protein 1 Kelch-like ECH-associated protein 1	KEAP1	172	Annotation score:
K7EPZ3	K7EPZ3_HUMAN	Kelch-like ECH-associated protein 1 Kelch-like ECH-associated protein 1	KEAP1	116	Annotation score:
K7EMY1	K7EMY1_HUMAN	Kelch-like ECH-associated protein 1 Kelch-like ECH-associated protein 1	KEAP1	129	Annotation score:

Sequence cautionⁱ

The sequence BAA09481 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	504	N → S in BAG51647 (PubMed:14702039).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_036084	23	C → Y in a breast cancer sample; somatic mutation. 1 Publication	1
Natural variantⁱVAR_032102	167	V → F in a lung adenocarcinoma patient. 1 Publication	1
Natural variantⁱVAR_032103	236	D → H in a NSCLC cell line. 1 Publication	1
Natural variantⁱVAR_032104	284	Q → L in a lung adenocarcinoma patient. 1 Publication	1
Natural variantⁱVAR_032105	333	G → C in a NSCLC cell line; strongly reduces interaction with NFE2L2 and reduces repression of NFE2L2-dependent gene expression. 1 Publication	1
Natural variantⁱVAR_032106	349	D → N1 PublicationCorresponds to variant dbSNP:rs1048289Ensembl.	1
Natural variantⁱVAR_032107	350	G → S in a NSCLC cell line. 1 PublicationCorresponds to variant dbSNP:rs777308626Ensembl.	1
Natural variantⁱVAR_032108	364	G → C in a lung adenocarcinoma cell line; also in NSCLC cell lines; may be a polymorphism; strongly reduces interaction with NFE2L2 and reduces repression of NFE2L2-dependent gene expression. 1 PublicationCorresponds to variant dbSNP:rs1397945617Ensembl.	1
Natural variantⁱVAR_032109	430	G → C in a lung adenocarcinoma patient; somatic mutation; strongly reduces interaction with NFE2L2 and reduces repression of NFE2L2-dependent gene expression. 1 Publication	1
Natural variantⁱVAR_036085	522	A → V in a breast cancer sample; somatic mutation. 1 Publication	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF361892 AF361891 Genomic DNA Translation: AAK43722.1 AF361886 mRNA Translation: AAK51082.1 D50922 mRNA Translation: BAA09481.3 Different initiation. AK056204 mRNA Translation: BAG51647.1 AC011461 Genomic DNA No translation available. BC002417 mRNA Translation: AAH02417.1 BC002930 mRNA Translation: AAH02930.1 BC015945 mRNA Translation: AAH15945.1 BC021957 mRNA Translation: AAH21957.2
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS12239.1
NCBI Reference Sequences More...RefSeqⁱ	NP_036421.2, NM_012289.3 NP_987096.1, NM_203500.1 XP_005260230.1, XM_005260173.1 XP_005260231.1, XM_005260174.1 XP_011526754.1, XM_011528452.1
UniGeneⁱ	Hs.465870

Genome annotation databases

Ensemblⁱ	ENST00000171111; ENSP00000171111; ENSG00000079999 ENST00000393623; ENSP00000377245; ENSG00000079999
GeneIDⁱ	9817
KEGGⁱ	hsa:9817
UCSC genome browser More...UCSCⁱ	uc002moq.2 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q14145	Kelch-like ECH-associated protein 1, isoform CRA_a		HUMAN		624	UniRef100_Q14145
KEAP1 isoform 1		PANTR		624
Uncharacterized protein		PANPA		624
Kelch like ECH associated protein 1		GORGO		624
Kelch-like ECH-associated protein 1 (Fragment)		HUMAN		212
+6

Protein	Similar proteins		Species	Score	Length	Source
Q14145	Kelch-like ECH-associated protein 1	)	MOUSE		624	UniRef90_Q14145
Kelch-like ECH-associated protein 1		PIG		624
Kelch-like ECH-associated protein 1		PONAB		624
Kelch-like ECH-associated protein 1		RAT		624
Kelch-like ECH-associated protein 1, isoform CRA_a		HUMAN		624
+142

Protein	Similar proteins		Species	Score	Length	Source
Q14145	Kelch-like ECH-associated protein 1		PONAB		624	UniRef50_Q14145
Kelch-like ECH-associated protein 1		RAT		624
Kelch-like ECH-associated protein 1		PIG		624
Kelch-like ECH-associated protein 1	)	MOUSE		624
Kelch-like ECH-associated protein 1, isoform CRA_a		HUMAN		624
+262

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF361892 AF361891 Genomic DNA Translation: AAK43722.1 AF361886 mRNA Translation: AAK51082.1 D50922 mRNA Translation: BAA09481.3 Different initiation. AK056204 mRNA Translation: BAG51647.1 AC011461 Genomic DNA No translation available. BC002417 mRNA Translation: AAH02417.1 BC002930 mRNA Translation: AAH02930.1 BC015945 mRNA Translation: AAH15945.1 BC021957 mRNA Translation: AAH21957.2
CCDSⁱ	CCDS12239.1
RefSeqⁱ	NP_036421.2, NM_012289.3 NP_987096.1, NM_203500.1 XP_005260230.1, XM_005260173.1 XP_005260231.1, XM_005260174.1 XP_011526754.1, XM_011528452.1
UniGeneⁱ	Hs.465870

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1U6D	X-ray	1.85	X	321-609	[»]
	1ZGK	X-ray	1.35	A	321-609	[»]
	2FLU	X-ray	1.50	X	321-609	[»]
	3VNG	X-ray	2.10	A	321-609	[»]
	3VNH	X-ray	2.10	A	321-609	[»]
	3ZGC	X-ray	2.20	A/B	321-609	[»]
	3ZGD	X-ray	1.98	A/B	321-609	[»]
	4CXI	X-ray	2.35	A	48-180	[»]
	4CXJ	X-ray	2.80	A	48-180	[»]
	4CXT	X-ray	2.66	A	48-180	[»]
	4IFJ	X-ray	1.80	A	321-609	[»]
	4IFL	X-ray	1.80	X	321-609	[»]
	4IFN	X-ray	2.40	X	321-609	[»]
	4IN4	X-ray	2.59	A/B/C	321-609	[»]
	4IQK	X-ray	1.97	A	321-609	[»]
	4L7B	X-ray	2.41	A/B	321-609	[»]
	4L7C	X-ray	2.40	A/B/C	321-609	[»]
	4L7D	X-ray	2.25	A/B/C	321-609	[»]
	4N1B	X-ray	2.55	A/B/C	321-609	[»]
	4XMB	X-ray	2.43	A	321-609	[»]
	5DAD	X-ray	2.61	A	49-182	[»]
	5DAF	X-ray	2.37	A	49-182	[»]
	5F72	X-ray	1.85	C/K	321-611	[»]
	5GIT	X-ray	2.19	A	48-180	[»]
	5NLB	X-ray	3.45	A	51-204	[»]
	5X54	X-ray	2.30	A/B	321-609	[»]
	6FMP	X-ray	2.92	A/B	321-609	[»]
	6FMQ	X-ray	2.10	A/B	321-609	[»]
ProteinModelPortalⁱ	Q14145
SMRⁱ	Q14145
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	115156, 132 interactors
CORUMⁱ	Q14145
DIPⁱ	DIP-42134N
ELMⁱ	Q14145
IntActⁱ	Q14145, 125 interactors
MINTⁱ	Q14145
STRINGⁱ	9606.ENSP00000171111

Chemistry databases

BindingDBⁱ	Q14145
ChEMBLⁱ	CHEMBL2069156
DrugBankⁱ	DB08908 Dimethyl fumarate
GuidetoPHARMACOLOGYⁱ	2757

PTM databases

iPTMnetⁱ	Q14145
PhosphoSitePlusⁱ	Q14145

Polymorphism and mutation databases

BioMutaⁱ	KEAP1
DMDMⁱ	146345444

Proteomic databases

EPDⁱ	Q14145
MaxQBⁱ	Q14145
PaxDbⁱ	Q14145
PeptideAtlasⁱ	Q14145
PRIDEⁱ	Q14145
ProteomicsDBⁱ	59849

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	9817
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000171111; ENSP00000171111; ENSG00000079999 ENST00000393623; ENSP00000377245; ENSG00000079999
GeneIDⁱ	9817
KEGGⁱ	hsa:9817
UCSCⁱ	uc002moq.2 human

Organism-specific databases

CTDⁱ	9817
DisGeNETⁱ	9817
EuPathDBⁱ	HostDB:ENSG00000079999.13
GeneCardsⁱ	KEAP1
HGNCⁱ	HGNC:23177 KEAP1
HPAⁱ	CAB025337 HPA005558
MalaCardsⁱ	KEAP1
MIMⁱ	606016 gene
neXtProtⁱ	NX_Q14145
OpenTargetsⁱ	ENSG00000079999
PharmGKBⁱ	PA134887774
HUGEⁱ	Search...
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG4441 Eukaryota ENOG410XNX8 LUCA
GeneTreeⁱ	ENSGT00760000118931
HOGENOMⁱ	HOG000230814
HOVERGENⁱ	HBG014286
InParanoidⁱ	Q14145
KOⁱ	K10456
OMAⁱ	EQIGCTE
OrthoDBⁱ	EOG091G02T3
PhylomeDBⁱ	Q14145
TreeFamⁱ	TF329218

Enzyme and pathway databases

UniPathwayⁱ	UPA00143
Reactomeⁱ	R-HSA-5689880 Ub-specific processing proteases R-HSA-8951664 Neddylation R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation
SIGNORⁱ	Q14145

Miscellaneous databases

ChiTaRSⁱ	KEAP1 human
EvolutionaryTraceⁱ	Q14145
GeneWikiⁱ	KEAP1
GenomeRNAiⁱ	9817
Protein Ontology More...PROⁱ	PR:Q14145
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000079999 Expressed in 229 organ(s), highest expression level in muscle of leg
CleanExⁱ	HS_KEAP1
ExpressionAtlasⁱ	Q14145 baseline and differential
Genevisibleⁱ	Q14145 HS

Family and domain databases

Gene3Dⁱ	2.120.10.80, 1 hit
InterProⁱ	View protein in InterPro IPR011705 BACK IPR017096 BTB-kelch_protein IPR000210 BTB/POZ_dom IPR030563 KEAP1 IPR015915 Kelch-typ_b-propeller IPR006652 Kelch_1 IPR011333 SKP1/BTB/POZ_sf
PANTHERⁱ	PTHR24412:SF162 PTHR24412:SF162, 1 hit
Pfamⁱ	View protein in Pfam PF07707 BACK, 1 hit PF00651 BTB, 1 hit PF01344 Kelch_1, 6 hits
PIRSFⁱ	PIRSF037037 Kelch-like_protein_gigaxonin, 1 hit
SMARTⁱ	View protein in SMART SM00875 BACK, 1 hit SM00225 BTB, 1 hit SM00612 Kelch, 6 hits
SUPFAMⁱ	SSF117281 SSF117281, 1 hit SSF54695 SSF54695, 1 hit
PROSITEⁱ	View protein in PROSITE PS50097 BTB, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	KEAP1_HUMAN
Accessionⁱ	Q14145Primary (citable) accession number: Q14145 Secondary accession number(s): B3KPD5 , Q6LEP0, Q8WTX1, Q9BPY9
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 27, 2001
	Last sequence update:	May 1, 2007
	Last modified:	October 10, 2018
	This is version 194 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
PATHWAY comments
Index of metabolic and biosynthesis pathways
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

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Help

UniRef

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UniProtKB - Q14145 (KEAP1_HUMAN)

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Kelch-like ECH-associated protein 1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Cytoskeleton

Cytosol

Endoplasmic reticulum

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Motif

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

Pathwayⁱ: protein ubiquitination

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ