UniProtKB - Q14145 (KEAP1_HUMAN)
Kelch-like ECH-associated protein 1
KEAP1
Functioni
Caution
Activity regulationi
: protein ubiquitination Pathwayi
This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.5 PublicationsView all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 151 | Sensor for electrophilic agents2 Publications | 1 | |
Sitei | 257 | Sensor for electrophilic agents1 Publication | 1 | |
Sitei | 273 | Sensor for electrophilic agents1 Publication | 1 | |
Sitei | 288 | Sensor for electrophilic agents1 Publication | 1 | |
Sitei | 434 | Sensor for electrophilic agentsBy similarity | 1 |
GO - Molecular functioni
- disordered domain specific binding Source: Ensembl
- identical protein binding Source: Ensembl
- transcription factor binding Source: ParkinsonsUK-UCL
GO - Biological processi
- cellular response to interleukin-4 Source: Ensembl
- cellular response to oxidative stress Source: UniProtKB
- cytoplasmic sequestering of transcription factor Source: GO_Central
- in utero embryonic development Source: Ensembl
- negative regulation of DNA-binding transcription factor activity Source: ParkinsonsUK-UCL
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process Source: ParkinsonsUK-UCL
- post-translational protein modification Source: Reactome
- protein deubiquitination Source: Reactome
- protein ubiquitination Source: UniProtKB
- regulation of autophagy Source: UniProtKB
- regulation of epidermal cell differentiation Source: Ensembl
- ubiquitin-dependent protein catabolic process Source: UniProtKB
- viral process Source: UniProtKB-KW
Keywordsi
Biological process | Host-virus interaction, Ubl conjugation pathway |
Enzyme and pathway databases
PathwayCommonsi | Q14145 |
Reactomei | R-HSA-5689880, Ub-specific processing proteases R-HSA-8951664, Neddylation R-HSA-983168, Antigen processing: Ubiquitination & Proteasome degradation |
SIGNORi | Q14145 |
UniPathwayi | UPA00143 |
Names & Taxonomyi
Protein namesi | Recommended name: Kelch-like ECH-associated protein 11 PublicationAlternative name(s): Cytosolic inhibitor of Nrf21 Publication Short name: INrf21 Publication Kelch-like protein 19Imported |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000079999.13 |
HGNCi | HGNC:23177, KEAP1 |
MIMi | 606016, gene |
neXtProti | NX_Q14145 |
Subcellular locationi
Cytoskeleton
- actin filament Source: Ensembl
- centriolar satellite Source: HPA
Cytosol
- cytosol Source: HPA
Endoplasmic reticulum
- endoplasmic reticulum Source: Ensembl
Nucleus
- nucleoplasm Source: HPA
Other locations
- Cul3-RING ubiquitin ligase complex Source: UniProtKB
- cytoplasm Source: UniProtKB
- inclusion body Source: UniProtKB
- midbody Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 15 | R → A: Reduced formation of a high-molecular mass KEAP1 molecule when methylglyoxal accumulates. 1 Publication | 1 | |
Mutagenesisi | 123 – 127 | VSIEG → ASAEA: Abolished interaction with NFE2L2/NRF2; when associated with 161-A-A-162. 1 Publication | 5 | |
Mutagenesisi | 125 – 127 | IEG → AAA: Increases ubiquitination and proteolytic degradation. 1 Publication | 3 | |
Mutagenesisi | 135 | R → A: Reduced formation of a high-molecular mass KEAP1 molecule when methylglyoxal accumulates. 1 Publication | 1 | |
Mutagenesisi | 151 | C → S, N, D or L: Substitution with a small side chain that prevents covalent modification by an electrophile; promotes constitutive ubiquitination of NFE2L2/NRF2 and subsequent repression of phase 2 detoxifying enzymes. Resistance of ubiquitination of PGAM5 to inhibition by oxidative stress and sulforaphane. Impaired interaction with CUL3. Reduced formation of a high-molecular mass KEAP1 molecule when methylglyoxal accumulates. 7 Publications | 1 | |
Mutagenesisi | 151 | C → W or Y: Substitution with a bulky side chain that mimicks covalent modification by an electrophile; prevents ubiquitination and degradation of NFE2L2/NRF2, leading to constitutive activation of NFE2L2/NRF2 and subsequent expression of phase 2 detoxifying enzymes. 2 Publications | 1 | |
Mutagenesisi | 161 – 162 | MY → AA: Abolished interaction with NFE2L2/NRF2; when associated with 123-A--A-127. 1 Publication | 2 | |
Mutagenesisi | 162 – 164 | YQI → AAA: Increases ubiquitination and proteolytic degradation. 1 Publication | 3 | |
Mutagenesisi | 273 | C → S: Abolishes repression of NFE2L2/NRF2-dependent gene expression. Slows down degradation of NFE2L2/NRF2. 1 Publication | 1 | |
Mutagenesisi | 288 | C → S: Abolishes repression of NFE2L2/NRF2-dependent gene expression. Slows down degradation of NFE2L2/NRF2. 1 Publication | 1 | |
Mutagenesisi | 308 | L → A: Loss of export from nucleus; when associated with A-310. 1 Publication | 1 | |
Mutagenesisi | 310 | L → A: Loss of export from nucleus; when associated with A-308. 1 Publication | 1 | |
Mutagenesisi | 334 | Y → A: Loss of interaction with NFE2L2/NRF2. Strongly reduces repression of NFE2L2/NRF2-dependent gene expression. Loss of interaction with PGAM5. 2 Publications | 1 | |
Mutagenesisi | 380 | R → A: Loss of interaction with NFE2L2/NRF2. Abolishes repression of NFE2L2/NRF2-dependent gene expression. Impaired interaction with SQSTM1/p62. 2 Publications | 1 | |
Mutagenesisi | 382 | N → A: Loss of interaction with NFE2L2/NRF2. Strongly reduces repression of NFE2L2/NRF2-dependent gene expression. Impaired interaction with SQSTM1/p62. 2 Publications | 1 | |
Mutagenesisi | 415 | R → A: Loss of interaction with NFE2L2/NRF2. Abolishes repression of NFE2L2/NRF2-dependent gene expression. Loss of interaction with PGAM5. Does not affect interaction with SQSTM1/p62. 3 Publications | 1 | |
Mutagenesisi | 436 | H → A: Loss of interaction with NFE2L2/NRF2. Abolishes repression of NFE2L2/NRF2-dependent gene expression. Does not affect interaction with SQSTM1/p62. 2 Publications | 1 | |
Mutagenesisi | 478 | F → A: Abolishes repression of NFE2L2/NRF2-dependent gene expression. 1 Publication | 1 | |
Mutagenesisi | 483 | R → A: Loss of interaction with NFE2L2/NRF2. Abolishes repression of NFE2L2/NRF2-dependent gene expression. Loss of interaction with PGAM5. Does not affect interaction with SQSTM1/p62. 3 Publications | 1 | |
Mutagenesisi | 525 | Y → A: Loss of interaction with NFE2L2/NRF2. Strongly reduces repression of NFE2L2/NRF2-dependent gene expression. Abolishes interaction with SQSTM1/p62. 2 Publications | 1 | |
Mutagenesisi | 572 | Y → A: Loss of interaction with NFE2L2/NRF2. Strongly reduces repression of NFE2L2/NRF2-dependent gene expression. Loss of interaction with PGAM5. Abolishes interaction with SQSTM1/p62. 3 Publications | 1 |
Organism-specific databases
DisGeNETi | 9817 |
MalaCardsi | KEAP1 |
OpenTargetsi | ENSG00000079999 |
Orphaneti | 276399, Familial multinodular goiter |
PharmGKBi | PA134887774 |
Miscellaneous databases
Pharosi | Q14145, Tclin |
Chemistry databases
ChEMBLi | CHEMBL2069156 |
DrugBanki | DB08908, Dimethyl fumarate |
DrugCentrali | Q14145 |
GuidetoPHARMACOLOGYi | 2757 |
Polymorphism and mutation databases
BioMutai | KEAP1 |
DMDMi | 146345444 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000119093 | 1 – 624 | Kelch-like ECH-associated protein 1Add BLAST | 624 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 38 | S-(2-succinyl)cysteineBy similarity | 1 | |
Cross-linki | 135 | N5-[4-(S-L-cysteinyl)-5-methyl-1H-imidazol-2-yl]-L-ornithine (Arg-Cys) (interchain with C-151 in KEAP1)1 Publication | ||
Modified residuei | 151 | S-(2,3-dicarboxypropyl)cysteine; alternate1 Publication | 1 | |
Modified residuei | 151 | S-(2-succinyl)cysteine; alternateBy similarity | 1 | |
Modified residuei | 151 | S-nitrosocysteine; alternateBy similarity | 1 | |
Cross-linki | 151 | N5-[4-(S-L-cysteinyl)-5-methyl-1H-imidazol-2-yl]-L-ornithine (Cys-Arg) (interchain with R-135 in KEAP1)1 Publication | ||
Modified residuei | 241 | S-(2-succinyl)cysteineBy similarity | 1 | |
Modified residuei | 257 | S-(2,3-dicarboxypropyl)cysteine1 Publication | 1 | |
Modified residuei | 273 | S-(2,3-dicarboxypropyl)cysteine1 Publication | 1 | |
Modified residuei | 288 | S-(2,3-dicarboxypropyl)cysteine; alternate1 Publication | 1 | |
Modified residuei | 288 | S-(2-succinyl)cysteine; alternateBy similarity | 1 | |
Modified residuei | 319 | S-(2-succinyl)cysteineBy similarity | 1 | |
Modified residuei | 434 | S-cGMP-cysteineBy similarity | 1 | |
Modified residuei | 613 | S-(2-succinyl)cysteineBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
S-nitrosylation, Ubl conjugationProteomic databases
EPDi | Q14145 |
jPOSTi | Q14145 |
MassIVEi | Q14145 |
MaxQBi | Q14145 |
PaxDbi | Q14145 |
PeptideAtlasi | Q14145 |
PRIDEi | Q14145 |
ProteomicsDBi | 59849 |
PTM databases
iPTMneti | Q14145 |
PhosphoSitePlusi | Q14145 |
SwissPalmi | Q14145 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000079999, Expressed in hindlimb stylopod muscle and 244 other tissues |
ExpressionAtlasi | Q14145, baseline and differential |
Genevisiblei | Q14145, HS |
Organism-specific databases
HPAi | ENSG00000079999, Low tissue specificity |
Interactioni
Subunit structurei
Component of the BCR(KEAP1) E3 ubiquitin ligase complex, at least composed of 2 molecules of CUL3, 2 molecules of KEAP1, and RBX1 (PubMed:15572695, PubMed:15983046, PubMed:15601839, PubMed:17127771, PubMed:18251510, PubMed:24896564).
Interacts with NFE2L2/NRF2; the interaction is direct (PubMed:15379550, PubMed:15601839, PubMed:16006525, PubMed:18387606, PubMed:16888629).
Forms a ternary complex with NFE2L2/NRF2 and PGAM5 (PubMed:17046835).
Interacts with (phosphorylated) SQSTM1/p62; the interaction is direct and inactivates the BCR(KEAP1) complex by sequestering it in inclusion bodies, promoting its degradation (PubMed:20495340, PubMed:20452972).
Interacts with NFE2L1 (PubMed:16687406).
Interacts with BPTF and PTMA (PubMed:15657435).
Interacts with MAP1LC3B (PubMed:24089205).
Interacts indirectly with ENC1 (PubMed:19424503).
Interacts with SESN1 and SESN2 (PubMed:23274085).
Interacts with HSP90AA1 and HSP90AB1 (PubMed:26517842).
19 Publications(Microbial infection) Interacts with ebolavirus protein VP24; this interaction activates transcription factor NFE2L2/NRF2 by blocking its interaction with KEAP1.
1 PublicationBinary interactionsi
Q14145
GO - Molecular functioni
- disordered domain specific binding Source: Ensembl
- identical protein binding Source: Ensembl
- transcription factor binding Source: ParkinsonsUK-UCL
Protein-protein interaction databases
BioGRIDi | 115156, 190 interactors |
CORUMi | Q14145 |
DIPi | DIP-42134N |
ELMi | Q14145 |
IntActi | Q14145, 141 interactors |
MINTi | Q14145 |
STRINGi | 9606.ENSP00000171111 |
Chemistry databases
BindingDBi | Q14145 |
Miscellaneous databases
RNActi | Q14145, protein |
Structurei
Secondary structure
3D structure databases
BMRBi | Q14145 |
SMRi | Q14145 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q14145 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 77 – 149 | BTBPROSITE-ProRule annotationAdd BLAST | 73 | |
Domaini | 184 – 286 | BACKAdd BLAST | 103 | |
Repeati | 327 – 372 | Kelch 1Add BLAST | 46 | |
Repeati | 373 – 423 | Kelch 2Add BLAST | 51 | |
Repeati | 424 – 470 | Kelch 3Add BLAST | 47 | |
Repeati | 471 – 517 | Kelch 4Add BLAST | 47 | |
Repeati | 518 – 564 | Kelch 5Add BLAST | 47 | |
Repeati | 565 – 611 | Kelch 6Add BLAST | 47 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Kelch repeat, RepeatPhylogenomic databases
eggNOGi | KOG4441, Eukaryota |
GeneTreei | ENSGT00940000159543 |
HOGENOMi | CLU_004253_14_2_1 |
InParanoidi | Q14145 |
OMAi | CYHPEND |
OrthoDBi | 746011at2759 |
PhylomeDBi | Q14145 |
TreeFami | TF329218 |
Family and domain databases
Gene3Di | 2.120.10.80, 1 hit |
IDEALi | IID00384 |
InterProi | View protein in InterPro IPR011705, BACK IPR017096, BTB-kelch_protein IPR000210, BTB/POZ_dom IPR030563, KEAP1 IPR015915, Kelch-typ_b-propeller IPR006652, Kelch_1 IPR011333, SKP1/BTB/POZ_sf |
PANTHERi | PTHR24412:SF162, PTHR24412:SF162, 1 hit |
Pfami | View protein in Pfam PF07707, BACK, 1 hit PF00651, BTB, 1 hit PF01344, Kelch_1, 6 hits |
PIRSFi | PIRSF037037, Kelch-like_protein_gigaxonin, 1 hit |
SMARTi | View protein in SMART SM00875, BACK, 1 hit SM00225, BTB, 1 hit SM00612, Kelch, 6 hits |
SUPFAMi | SSF117281, SSF117281, 1 hit SSF54695, SSF54695, 1 hit |
PROSITEi | View protein in PROSITE PS50097, BTB, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MQPDPRPSGA GACCRFLPLQ SQCPEGAGDA VMYASTECKA EVTPSQHGNR
60 70 80 90 100
TFSYTLEDHT KQAFGIMNEL RLSQQLCDVT LQVKYQDAPA AQFMAHKVVL
110 120 130 140 150
ASSSPVFKAM FTNGLREQGM EVVSIEGIHP KVMERLIEFA YTASISMGEK
160 170 180 190 200
CVLHVMNGAV MYQIDSVVRA CSDFLVQQLD PSNAIGIANF AEQIGCVELH
210 220 230 240 250
QRAREYIYMH FGEVAKQEEF FNLSHCQLVT LISRDDLNVR CESEVFHACI
260 270 280 290 300
NWVKYDCEQR RFYVQALLRA VRCHSLTPNF LQMQLQKCEI LQSDSRCKDY
310 320 330 340 350
LVKIFEELTL HKPTQVMPCR APKVGRLIYT AGGYFRQSLS YLEAYNPSDG
360 370 380 390 400
TWLRLADLQV PRSGLAGCVV GGLLYAVGGR NNSPDGNTDS SALDCYNPMT
410 420 430 440 450
NQWSPCAPMS VPRNRIGVGV IDGHIYAVGG SHGCIHHNSV ERYEPERDEW
460 470 480 490 500
HLVAPMLTRR IGVGVAVLNR LLYAVGGFDG TNRLNSAECY YPERNEWRMI
510 520 530 540 550
TAMNTIRSGA GVCVLHNCIY AAGGYDGQDQ LNSVERYDVE TETWTFVAPM
560 570 580 590 600
KHRRSALGIT VHQGRIYVLG GYDGHTFLDS VECYDPDTDT WSEVTRMTSG
610 620
RSGVGVAVTM EPCRKQIDQQ NCTC
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketK7EJ49 | K7EJ49_HUMAN | Kelch-like ECH-associated protein 1 | KEAP1 | 212 | Annotation score: | ||
K7ESE0 | K7ESE0_HUMAN | Kelch-like ECH-associated protein 1 | KEAP1 | 279 | Annotation score: | ||
K7EJD8 | K7EJD8_HUMAN | Kelch-like ECH-associated protein 1 | KEAP1 | 213 | Annotation score: | ||
K7EQX2 | K7EQX2_HUMAN | Kelch-like ECH-associated protein 1 | KEAP1 | 172 | Annotation score: | ||
K7EMY1 | K7EMY1_HUMAN | Kelch-like ECH-associated protein 1 | KEAP1 | 129 | Annotation score: | ||
K7EPZ3 | K7EPZ3_HUMAN | Kelch-like ECH-associated protein 1 | KEAP1 | 116 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 504 | N → S in BAG51647 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_036084 | 23 | C → Y in a breast cancer sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_032102 | 167 | V → F in a lung adenocarcinoma patient. 1 Publication | 1 | |
Natural variantiVAR_032103 | 236 | D → H in a NSCLC cell line. 1 Publication | 1 | |
Natural variantiVAR_032104 | 284 | Q → L in a lung adenocarcinoma patient. 1 Publication | 1 | |
Natural variantiVAR_032105 | 333 | G → C in a NSCLC cell line; strongly reduces interaction with NFE2L2/NRF2 and reduces repression of NFE2L2/NRF2-dependent gene expression. 1 Publication | 1 | |
Natural variantiVAR_032106 | 349 | D → N1 PublicationCorresponds to variant dbSNP:rs1048289Ensembl. | 1 | |
Natural variantiVAR_032107 | 350 | G → S in a NSCLC cell line. 1 PublicationCorresponds to variant dbSNP:rs777308626Ensembl. | 1 | |
Natural variantiVAR_032108 | 364 | G → C in a lung adenocarcinoma cell line; also in NSCLC cell lines; may be a polymorphism; strongly reduces interaction with NFE2L2/NRF2 and reduces repression of NFE2L2/NRF2-dependent gene expression. 1 PublicationCorresponds to variant dbSNP:rs1397945617Ensembl. | 1 | |
Natural variantiVAR_032109 | 430 | G → C in a lung adenocarcinoma patient; somatic mutation; strongly reduces interaction with NFE2L2/NRF2 and reduces repression of NFE2L2/NRF2-dependent gene expression. 1 Publication | 1 | |
Natural variantiVAR_036085 | 522 | A → V in a breast cancer sample; somatic mutation. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF361892 , AF361888, AF361889, AF361890, AF361891 Genomic DNA Translation: AAK43722.1 AF361886 mRNA Translation: AAK51082.1 D50922 mRNA Translation: BAA09481.3 Different initiation. AK056204 mRNA Translation: BAG51647.1 AC011461 Genomic DNA No translation available. BC002417 mRNA Translation: AAH02417.1 BC002930 mRNA Translation: AAH02930.1 BC015945 mRNA Translation: AAH15945.1 BC021957 mRNA Translation: AAH21957.2 |
CCDSi | CCDS12239.1 |
RefSeqi | NP_036421.2, NM_012289.3 NP_987096.1, NM_203500.1 XP_005260230.1, XM_005260173.1 XP_005260231.1, XM_005260174.1 XP_011526754.1, XM_011528452.1 |
Genome annotation databases
Ensembli | ENST00000171111; ENSP00000171111; ENSG00000079999 ENST00000393623; ENSP00000377245; ENSG00000079999 |
GeneIDi | 9817 |
KEGGi | hsa:9817 |
UCSCi | uc002moq.2, human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF361892 , AF361888, AF361889, AF361890, AF361891 Genomic DNA Translation: AAK43722.1 AF361886 mRNA Translation: AAK51082.1 D50922 mRNA Translation: BAA09481.3 Different initiation. AK056204 mRNA Translation: BAG51647.1 AC011461 Genomic DNA No translation available. BC002417 mRNA Translation: AAH02417.1 BC002930 mRNA Translation: AAH02930.1 BC015945 mRNA Translation: AAH15945.1 BC021957 mRNA Translation: AAH21957.2 |
CCDSi | CCDS12239.1 |
RefSeqi | NP_036421.2, NM_012289.3 NP_987096.1, NM_203500.1 XP_005260230.1, XM_005260173.1 XP_005260231.1, XM_005260174.1 XP_011526754.1, XM_011528452.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1U6D | X-ray | 1.85 | X | 321-609 | [»] | |
1ZGK | X-ray | 1.35 | A | 321-609 | [»] | |
2FLU | X-ray | 1.50 | X | 321-609 | [»] | |
3VNG | X-ray | 2.10 | A | 321-609 | [»] | |
3VNH | X-ray | 2.10 | A | 321-609 | [»] | |
3ZGC | X-ray | 2.20 | A/B | 321-609 | [»] | |
3ZGD | X-ray | 1.98 | A/B | 321-609 | [»] | |
4CXI | X-ray | 2.35 | A | 48-180 | [»] | |
4CXJ | X-ray | 2.80 | A | 48-180 | [»] | |
4CXT | X-ray | 2.66 | A | 48-180 | [»] | |
4IFJ | X-ray | 1.80 | A | 321-609 | [»] | |
4IFL | X-ray | 1.80 | X | 321-609 | [»] | |
4IFN | X-ray | 2.40 | X | 321-609 | [»] | |
4IN4 | X-ray | 2.59 | A/B/C | 321-609 | [»] | |
4IQK | X-ray | 1.97 | A | 321-609 | [»] | |
4L7B | X-ray | 2.41 | A/B | 321-609 | [»] | |
4L7C | X-ray | 2.40 | A/B/C | 321-609 | [»] | |
4L7D | X-ray | 2.25 | A/B/C | 321-609 | [»] | |
4N1B | X-ray | 2.55 | A/B/C | 321-609 | [»] | |
4XMB | X-ray | 2.43 | A | 321-609 | [»] | |
5DAD | X-ray | 2.61 | A | 49-182 | [»] | |
5DAF | X-ray | 2.37 | A | 49-182 | [»] | |
5F72 | X-ray | 1.85 | C/K | 321-611 | [»] | |
5GIT | X-ray | 2.19 | A | 48-180 | [»] | |
5NLB | X-ray | 3.45 | A | 51-204 | [»] | |
5WFL | X-ray | 1.93 | A/B | 312-624 | [»] | |
5WFV | X-ray | 1.91 | A/B | 320-612 | [»] | |
5WG1 | X-ray | 2.02 | A/B | 320-612 | [»] | |
5WHL | X-ray | 2.50 | A/B | 312-624 | [»] | |
5WHO | X-ray | 2.23 | A/B | 312-624 | [»] | |
5WIY | X-ray | 2.23 | A/B | 312-624 | [»] | |
5X54 | X-ray | 2.30 | A/B | 321-609 | [»] | |
6FFM | X-ray | 2.20 | A | 48-180 | [»] | |
6FMP | X-ray | 2.92 | A/B | 321-609 | [»] | |
6FMQ | X-ray | 2.10 | A/B | 321-609 | [»] | |
6HWS | X-ray | 1.75 | A | 321-609 | [»] | |
6ROG | X-ray | 2.16 | A/X | 321-609 | [»] | |
6SP1 | X-ray | 2.57 | A/B | 321-609 | [»] | |
6SP4 | X-ray | 2.59 | A/B/C/D/E/F | 321-609 | [»] | |
6T7V | X-ray | 2.60 | A | 321-609 | [»] | |
6T7Z | X-ray | 2.00 | A | 321-609 | [»] | |
6TYM | X-ray | 1.42 | A | 321-609 | [»] | |
6TYP | X-ray | 2.50 | A | 321-609 | [»] | |
6UF0 | X-ray | 1.96 | A/B | 321-609 | [»] | |
6V6Z | X-ray | 1.60 | A/B/C/D | 321-609 | [»] | |
6W66 | X-ray | 3.21 | C | 48-180 | [»] | |
6W67 | X-ray | 2.20 | A | 48-180 | [»] | |
6W68 | X-ray | 2.55 | A | 48-180 | [»] | |
6W69 | X-ray | 2.50 | A | 48-180 | [»] | |
6WCQ | electron microscopy | 8.50 | C | 1-624 | [»] | |
BMRBi | Q14145 | |||||
SMRi | Q14145 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 115156, 190 interactors |
CORUMi | Q14145 |
DIPi | DIP-42134N |
ELMi | Q14145 |
IntActi | Q14145, 141 interactors |
MINTi | Q14145 |
STRINGi | 9606.ENSP00000171111 |
Chemistry databases
BindingDBi | Q14145 |
ChEMBLi | CHEMBL2069156 |
DrugBanki | DB08908, Dimethyl fumarate |
DrugCentrali | Q14145 |
GuidetoPHARMACOLOGYi | 2757 |
PTM databases
iPTMneti | Q14145 |
PhosphoSitePlusi | Q14145 |
SwissPalmi | Q14145 |
Polymorphism and mutation databases
BioMutai | KEAP1 |
DMDMi | 146345444 |
Proteomic databases
EPDi | Q14145 |
jPOSTi | Q14145 |
MassIVEi | Q14145 |
MaxQBi | Q14145 |
PaxDbi | Q14145 |
PeptideAtlasi | Q14145 |
PRIDEi | Q14145 |
ProteomicsDBi | 59849 |
Protocols and materials databases
ABCDi | Q14145, 5 sequenced antibodies |
Antibodypediai | 1418, 670 antibodies |
DNASUi | 9817 |
Genome annotation databases
Ensembli | ENST00000171111; ENSP00000171111; ENSG00000079999 ENST00000393623; ENSP00000377245; ENSG00000079999 |
GeneIDi | 9817 |
KEGGi | hsa:9817 |
UCSCi | uc002moq.2, human |
Organism-specific databases
CTDi | 9817 |
DisGeNETi | 9817 |
EuPathDBi | HostDB:ENSG00000079999.13 |
GeneCardsi | KEAP1 |
HGNCi | HGNC:23177, KEAP1 |
HPAi | ENSG00000079999, Low tissue specificity |
MalaCardsi | KEAP1 |
MIMi | 606016, gene |
neXtProti | NX_Q14145 |
OpenTargetsi | ENSG00000079999 |
Orphaneti | 276399, Familial multinodular goiter |
PharmGKBi | PA134887774 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4441, Eukaryota |
GeneTreei | ENSGT00940000159543 |
HOGENOMi | CLU_004253_14_2_1 |
InParanoidi | Q14145 |
OMAi | CYHPEND |
OrthoDBi | 746011at2759 |
PhylomeDBi | Q14145 |
TreeFami | TF329218 |
Enzyme and pathway databases
UniPathwayi | UPA00143 |
PathwayCommonsi | Q14145 |
Reactomei | R-HSA-5689880, Ub-specific processing proteases R-HSA-8951664, Neddylation R-HSA-983168, Antigen processing: Ubiquitination & Proteasome degradation |
SIGNORi | Q14145 |
Miscellaneous databases
BioGRID-ORCSi | 9817, 135 hits in 864 CRISPR screens |
ChiTaRSi | KEAP1, human |
EvolutionaryTracei | Q14145 |
GeneWikii | KEAP1 |
GenomeRNAii | 9817 |
Pharosi | Q14145, Tclin |
PROi | PR:Q14145 |
RNActi | Q14145, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000079999, Expressed in hindlimb stylopod muscle and 244 other tissues |
ExpressionAtlasi | Q14145, baseline and differential |
Genevisiblei | Q14145, HS |
Family and domain databases
Gene3Di | 2.120.10.80, 1 hit |
IDEALi | IID00384 |
InterProi | View protein in InterPro IPR011705, BACK IPR017096, BTB-kelch_protein IPR000210, BTB/POZ_dom IPR030563, KEAP1 IPR015915, Kelch-typ_b-propeller IPR006652, Kelch_1 IPR011333, SKP1/BTB/POZ_sf |
PANTHERi | PTHR24412:SF162, PTHR24412:SF162, 1 hit |
Pfami | View protein in Pfam PF07707, BACK, 1 hit PF00651, BTB, 1 hit PF01344, Kelch_1, 6 hits |
PIRSFi | PIRSF037037, Kelch-like_protein_gigaxonin, 1 hit |
SMARTi | View protein in SMART SM00875, BACK, 1 hit SM00225, BTB, 1 hit SM00612, Kelch, 6 hits |
SUPFAMi | SSF117281, SSF117281, 1 hit SSF54695, SSF54695, 1 hit |
PROSITEi | View protein in PROSITE PS50097, BTB, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | KEAP1_HUMAN | |
Accessioni | Q14145Primary (citable) accession number: Q14145 Secondary accession number(s): B3KPD5 Q9BPY9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 27, 2001 |
Last sequence update: | May 1, 2007 | |
Last modified: | December 2, 2020 | |
This is version 211 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PATHWAY comments
Index of metabolic and biosynthesis pathways - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations