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Protein

SERTA domain-containing protein 2

Gene

SERTAD2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts at E2F-responsive promoters as coregulator to integrate signals provided by PHD- and/or bromodomain-containing transcription factors. May act as coactivator as well as corepressor of E2F1-TFDP1 and E2F4-TFDP1 complexes on E2F consensus binding sites, which would activate or inhibit E2F-target genes expression. Modulates fat storage by down-regulating the expression of key genes involved in adipocyte lipolysis, thermogenesis and oxidative metabolism.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
SERTA domain-containing protein 2
Alternative name(s):
Transcriptional regulator interacting with the PHD-bromodomain 2
Short name:
TRIP-Br2
Gene namesi
Name:SERTAD2
Synonyms:KIAA0127, TRIPBR2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000179833.4
HGNCiHGNC:30784 SERTAD2
MIMi617851 gene
neXtProtiNX_Q14140

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi238L → A: Abolishes the interaction with XPO1 as well as the nuclear export and the subsequent proteasomal degradation. 1 Publication1
Mutagenesisi241L → A: Slight resistance to proteasomal degradation, no effect on the interaction with XPO1 neither on nuclear export. 1 Publication1
Mutagenesisi243L → A: Slight decrease of interaction with XPO1 and resistance to proteasomal degradation, no effect on nuclear export. 1 Publication1

Organism-specific databases

DisGeNETi9792
OpenTargetsiENSG00000179833
PharmGKBiPA134948884

Polymorphism and mutation databases

BioMutaiSERTAD2
DMDMi3123047

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001916131 – 314SERTA domain-containing protein 2Add BLAST314

Post-translational modificationi

Polyubiquitinated, which promotes proteasomal degradation.1 Publication

Keywords - PTMi

Ubl conjugation

Proteomic databases

PaxDbiQ14140
PeptideAtlasiQ14140
PRIDEiQ14140
ProteomicsDBi59842

PTM databases

iPTMnetiQ14140
PhosphoSitePlusiQ14140

Expressioni

Tissue specificityi

Expressed in adipose tissue.1 Publication

Developmental stagei

Transcript levels remain constant in all phases of the cell cycle. In contrast, protein levels accumulate at the G1/S phase boundary and decrease progressively through S phase until G2/M phase is reached, residual expression is observed in the G2/M and early G1 phases.1 Publication

Gene expression databases

BgeeiENSG00000179833
CleanExiHS_SERTAD2
GenevisibleiQ14140 HS

Organism-specific databases

HPAiHPA019021
HPA020904

Interactioni

Subunit structurei

Interacts with XPO1; which mediates nuclear export. Interacts with TFDP1; modulates transactivation activity of TFDP1/E2F complexes.2 Publications

Protein-protein interaction databases

BioGridi115136, 9 interactors
IntActiQ14140, 20 interactors

Structurei

3D structure databases

ProteinModelPortaliQ14140
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 80SERTAPROSITE-ProRule annotationAdd BLAST48

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni235 – 311Required for transactivation activityAdd BLAST77

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi238 – 243Nuclear export signal (NES)6

Phylogenomic databases

eggNOGiENOG410IEG3 Eukaryota
ENOG4110A16 LUCA
GeneTreeiENSGT00530000063867
HOGENOMiHOG000111497
HOVERGENiHBG097654
InParanoidiQ14140
OMAiDSLPGNF
OrthoDBiEOG091G0F8L
PhylomeDBiQ14140
TreeFamiTF331620

Family and domain databases

InterProiView protein in InterPro
IPR009263 SERTA_dom
PfamiView protein in Pfam
PF06031 SERTA, 1 hit
PROSITEiView protein in PROSITE
PS51053 SERTA, 1 hit

Sequencei

Sequence statusi: Complete.

Q14140-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGKGGKRKF DEHEDGLEGK IVSPCDGPSK VSYTLQRQTI FNISLMKLYN
60 70 80 90 100
HRPLTEPSLQ KTVLINNMLR RIQEELKQEG SLRPMFTPSS QPTTEPSDSY
110 120 130 140 150
REAPPAFSHL ASPSSHPCDL GSTTPLEACL TPASLLEDDD DTFCTSQAMQ
160 170 180 190 200
PTAPTKLSPP ALLPEKDSFS SALDEIEELC PTSTSTEAAT AATDSVKGTS
210 220 230 240 250
SEAGTQKLDG PQESRADDSK LMDSLPGNFE ITTSTGFLTD LTLDDILFAD
260 270 280 290 300
IDTSMYDFDP CTSSSGTASK MAPVSADDLL KTLAPYSSQP VTPSQPFKMD
310
LTELDHIMEV LVGS
Length:314
Mass (Da):33,897
Last modified:November 1, 1996 - v1
Checksum:iE43107FC565AAC31
GO

Sequence cautioni

The sequence BAA09476 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50917 mRNA Translation: BAA09476.2 Different initiation.
AC007365 Genomic DNA Translation: AAY14766.1
BC074788 mRNA Translation: AAH74788.1
BC074789 mRNA Translation: AAH74789.1
BC101639 mRNA Translation: AAI01640.1
BC101641 mRNA Translation: AAI01642.1
CCDSiCCDS33210.1
RefSeqiNP_055570.1, NM_014755.2
XP_005264726.1, XM_005264669.2
XP_011531507.1, XM_011533205.2
UniGeneiHs.591569
Hs.662573

Genome annotation databases

EnsembliENST00000313349; ENSP00000326933; ENSG00000179833
GeneIDi9792
KEGGihsa:9792
UCSCiuc002sde.3 human

Similar proteinsi

Entry informationi

Entry nameiSRTD2_HUMAN
AccessioniPrimary (citable) accession number: Q14140
Secondary accession number(s): Q53TS2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: July 18, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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