UniProtKB - Q14140 (SRTD2_HUMAN)
Protein
SERTA domain-containing protein 2
Gene
SERTAD2
Organism
Homo sapiens (Human)
Status
Functioni
Acts at E2F-responsive promoters as coregulator to integrate signals provided by PHD- and/or bromodomain-containing transcription factors. May act as coactivator as well as corepressor of E2F1-TFDP1 and E2F4-TFDP1 complexes on E2F consensus binding sites, which would activate or inhibit E2F-target genes expression. Modulates fat storage by down-regulating the expression of key genes involved in adipocyte lipolysis, thermogenesis and oxidative metabolism.1 Publication
GO - Molecular functioni
- transcription coactivator activity Source: Ensembl
GO - Biological processi
- chromatin-mediated maintenance of transcription Source: GO_Central
- negative regulation of cell growth Source: MGI
Keywordsi
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | Q14140 |
Names & Taxonomyi
Protein namesi | Recommended name: SERTA domain-containing protein 2Alternative name(s): Transcriptional regulator interacting with the PHD-bromodomain 2 Short name: TRIP-Br2 |
Gene namesi | Name:SERTAD2 Synonyms:KIAA0127, TRIPBR2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:30784, SERTAD2 |
MIMi | 617851, gene |
neXtProti | NX_Q14140 |
VEuPathDBi | HostDB:ENSG00000179833.4 |
Subcellular locationi
Cytosol
- cytosol Source: HPA
Nucleus
- nucleoplasm Source: HPA
- nucleus Source: MGI
Other locations
- cytoplasm Source: MGI
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 238 | L → A: Abolishes the interaction with XPO1 as well as the nuclear export and the subsequent proteasomal degradation. 1 Publication | 1 | |
Mutagenesisi | 241 | L → A: Slight resistance to proteasomal degradation, no effect on the interaction with XPO1 neither on nuclear export. 1 Publication | 1 | |
Mutagenesisi | 243 | L → A: Slight decrease of interaction with XPO1 and resistance to proteasomal degradation, no effect on nuclear export. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 9792 |
OpenTargetsi | ENSG00000179833 |
PharmGKBi | PA134948884 |
Miscellaneous databases
Pharosi | Q14140, Tbio |
Genetic variation databases
BioMutai | SERTAD2 |
DMDMi | 3123047 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000191613 | 1 – 314 | SERTA domain-containing protein 2Add BLAST | 314 |
Post-translational modificationi
Polyubiquitinated, which promotes proteasomal degradation.1 Publication
Keywords - PTMi
Ubl conjugationProteomic databases
MassIVEi | Q14140 |
PaxDbi | Q14140 |
PeptideAtlasi | Q14140 |
PRIDEi | Q14140 |
ProteomicsDBi | 59842 |
PTM databases
iPTMneti | Q14140 |
PhosphoSitePlusi | Q14140 |
Expressioni
Tissue specificityi
Expressed in adipose tissue.1 Publication
Developmental stagei
Transcript levels remain constant in all phases of the cell cycle. In contrast, protein levels accumulate at the G1/S phase boundary and decrease progressively through S phase until G2/M phase is reached, residual expression is observed in the G2/M and early G1 phases.1 Publication
Gene expression databases
Bgeei | ENSG00000179833, Expressed in cartilage tissue and 249 other tissues |
Genevisiblei | Q14140, HS |
Organism-specific databases
HPAi | ENSG00000179833, Tissue enhanced (lymphoid) |
Interactioni
Subunit structurei
Interacts with XPO1; which mediates nuclear export.
Interacts with TFDP1; modulates transactivation activity of TFDP1/E2F complexes.
2 PublicationsBinary interactionsi
Hide detailsQ14140
Protein-protein interaction databases
BioGRIDi | 115136, 27 interactors |
IntActi | Q14140, 19 interactors |
STRINGi | 9606.ENSP00000326933 |
Miscellaneous databases
RNActi | Q14140, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 33 – 80 | SERTAPROSITE-ProRule annotationAdd BLAST | 48 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 235 – 311 | Required for transactivation activityAdd BLAST | 77 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 238 – 243 | Nuclear export signal (NES) | 6 |
Phylogenomic databases
eggNOGi | ENOG502QUG8, Eukaryota |
GeneTreei | ENSGT00530000063867 |
HOGENOMi | CLU_065586_0_0_1 |
InParanoidi | Q14140 |
OMAi | AHPCDLG |
OrthoDBi | 1188137at2759 |
PhylomeDBi | Q14140 |
TreeFami | TF331620 |
Family and domain databases
InterProi | View protein in InterPro IPR009263, SERTA_dom |
Pfami | View protein in Pfam PF06031, SERTA, 1 hit |
PROSITEi | View protein in PROSITE PS51053, SERTA, 1 hit |
i Sequence
Sequence statusi: Complete.
Q14140-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLGKGGKRKF DEHEDGLEGK IVSPCDGPSK VSYTLQRQTI FNISLMKLYN
60 70 80 90 100
HRPLTEPSLQ KTVLINNMLR RIQEELKQEG SLRPMFTPSS QPTTEPSDSY
110 120 130 140 150
REAPPAFSHL ASPSSHPCDL GSTTPLEACL TPASLLEDDD DTFCTSQAMQ
160 170 180 190 200
PTAPTKLSPP ALLPEKDSFS SALDEIEELC PTSTSTEAAT AATDSVKGTS
210 220 230 240 250
SEAGTQKLDG PQESRADDSK LMDSLPGNFE ITTSTGFLTD LTLDDILFAD
260 270 280 290 300
IDTSMYDFDP CTSSSGTASK MAPVSADDLL KTLAPYSSQP VTPSQPFKMD
310
LTELDHIMEV LVGS
Sequence cautioni
The sequence BAA09476 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D50917 mRNA Translation: BAA09476.2 Different initiation. AC007365 Genomic DNA Translation: AAY14766.1 BC074788 mRNA Translation: AAH74788.1 BC074789 mRNA Translation: AAH74789.1 BC101639 mRNA Translation: AAI01640.1 BC101641 mRNA Translation: AAI01642.1 |
CCDSi | CCDS33210.1 |
RefSeqi | NP_055570.1, NM_014755.2 XP_005264726.1, XM_005264669.2 XP_011531507.1, XM_011533205.2 |
Genome annotation databases
Ensembli | ENST00000313349; ENSP00000326933; ENSG00000179833 |
GeneIDi | 9792 |
KEGGi | hsa:9792 |
UCSCi | uc002sde.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D50917 mRNA Translation: BAA09476.2 Different initiation. AC007365 Genomic DNA Translation: AAY14766.1 BC074788 mRNA Translation: AAH74788.1 BC074789 mRNA Translation: AAH74789.1 BC101639 mRNA Translation: AAI01640.1 BC101641 mRNA Translation: AAI01642.1 |
CCDSi | CCDS33210.1 |
RefSeqi | NP_055570.1, NM_014755.2 XP_005264726.1, XM_005264669.2 XP_011531507.1, XM_011533205.2 |
3D structure databases
SMRi | Q14140 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 115136, 27 interactors |
IntActi | Q14140, 19 interactors |
STRINGi | 9606.ENSP00000326933 |
PTM databases
iPTMneti | Q14140 |
PhosphoSitePlusi | Q14140 |
Genetic variation databases
BioMutai | SERTAD2 |
DMDMi | 3123047 |
Proteomic databases
MassIVEi | Q14140 |
PaxDbi | Q14140 |
PeptideAtlasi | Q14140 |
PRIDEi | Q14140 |
ProteomicsDBi | 59842 |
Protocols and materials databases
Antibodypediai | 16073, 140 antibodies |
DNASUi | 9792 |
Genome annotation databases
Ensembli | ENST00000313349; ENSP00000326933; ENSG00000179833 |
GeneIDi | 9792 |
KEGGi | hsa:9792 |
UCSCi | uc002sde.3, human |
Organism-specific databases
CTDi | 9792 |
DisGeNETi | 9792 |
GeneCardsi | SERTAD2 |
HGNCi | HGNC:30784, SERTAD2 |
HPAi | ENSG00000179833, Tissue enhanced (lymphoid) |
MIMi | 617851, gene |
neXtProti | NX_Q14140 |
OpenTargetsi | ENSG00000179833 |
PharmGKBi | PA134948884 |
VEuPathDBi | HostDB:ENSG00000179833.4 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QUG8, Eukaryota |
GeneTreei | ENSGT00530000063867 |
HOGENOMi | CLU_065586_0_0_1 |
InParanoidi | Q14140 |
OMAi | AHPCDLG |
OrthoDBi | 1188137at2759 |
PhylomeDBi | Q14140 |
TreeFami | TF331620 |
Enzyme and pathway databases
PathwayCommonsi | Q14140 |
Miscellaneous databases
BioGRID-ORCSi | 9792, 9 hits in 1000 CRISPR screens |
ChiTaRSi | SERTAD2, human |
GenomeRNAii | 9792 |
Pharosi | Q14140, Tbio |
PROi | PR:Q14140 |
RNActi | Q14140, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000179833, Expressed in cartilage tissue and 249 other tissues |
Genevisiblei | Q14140, HS |
Family and domain databases
InterProi | View protein in InterPro IPR009263, SERTA_dom |
Pfami | View protein in Pfam PF06031, SERTA, 1 hit |
PROSITEi | View protein in PROSITE PS51053, SERTA, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SRTD2_HUMAN | |
Accessioni | Q14140Primary (citable) accession number: Q14140 Secondary accession number(s): Q53TS2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1998 |
Last sequence update: | November 1, 1996 | |
Last modified: | April 7, 2021 | |
This is version 146 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot