SERTAD2

Functionⁱ

Acts at E2F-responsive promoters as coregulator to integrate signals provided by PHD- and/or bromodomain-containing transcription factors. May act as coactivator as well as corepressor of E2F1-TFDP1 and E2F4-TFDP1 complexes on E2F consensus binding sites, which would activate or inhibit E2F-target genes expression. Modulates fat storage by down-regulating the expression of key genes involved in adipocyte lipolysis, thermogenesis and oxidative metabolism.1 Publication

GO - Molecular functionⁱ

transcription coactivator activity Source: Ensembl

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

negative regulation of cell growth
Source: MGI
Inferred from direct assayⁱ
- 16098148
positive regulation of transcription, DNA-templated Source: Ensembl
transcription, DNA-templated Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Transcription, Transcription regulation

Biological process

Transcription, Transcription regulation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: SERTA domain-containing protein 2 Alternative name(s): Transcriptional regulator interacting with the PHD-bromodomain 2 Short name: TRIP-Br2
Gene namesⁱ	Name:SERTAD2 Synonyms:KIAA0127, TRIPBR2
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 2

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000179833.4
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:30784 SERTAD2
MIMⁱ	617851 gene
neXtProtⁱ	NX_Q14140

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	238	L → A: Abolishes the interaction with XPO1 as well as the nuclear export and the subsequent proteasomal degradation. 1 Publication	1
Mutagenesisⁱ	241	L → A: Slight resistance to proteasomal degradation, no effect on the interaction with XPO1 neither on nuclear export. 1 Publication	1
Mutagenesisⁱ	243	L → A: Slight decrease of interaction with XPO1 and resistance to proteasomal degradation, no effect on nuclear export. 1 Publication	1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	9792
Open Targets More...OpenTargetsⁱ	ENSG00000179833
PharmGKBⁱ	PA134948884

Polymorphism and mutation databases

BioMutaⁱ	SERTAD2
DMDMⁱ	3123047

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000191613	1 – 314	SERTA domain-containing protein 2Add BLAST		314

Post-translational modificationⁱ

Polyubiquitinated, which promotes proteasomal degradation.1 Publication

Keywords - PTMⁱ

Ubl conjugation

Proteomic databases

PaxDbⁱ	Q14140
PeptideAtlas More...PeptideAtlasⁱ	Q14140
PRIDEⁱ	Q14140
ProteomicsDBⁱ	59842

PTM databases

iPTMnetⁱ	Q14140
PhosphoSitePlusⁱ	Q14140

Expressionⁱ

Tissue specificityⁱ

Developmental stageⁱ

Transcript levels remain constant in all phases of the cell cycle. In contrast, protein levels accumulate at the G1/S phase boundary and decrease progressively through S phase until G2/M phase is reached, residual expression is observed in the G2/M and early G1 phases.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000179833
CleanExⁱ	HS_SERTAD2
Genevisibleⁱ	Q14140 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA019021 HPA020904

HPAⁱ

HPA019021
HPA020904

Interactionⁱ

Subunit structureⁱ

Interacts with XPO1; which mediates nuclear export. Interacts with TFDP1; modulates transactivation activity of TFDP1/E2F complexes.2 Publications

Protein-protein interaction databases

BioGridⁱ	115136, 9 interactors
IntActⁱ	Q14140, 20 interactors

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q14140
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	33 – 80	SERTAPROSITE-ProRule annotationAdd BLAST		48

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	235 – 311	Required for transactivation activityAdd BLAST		77

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	238 – 243	Nuclear export signal (NES)		6

Phylogenomic databases

eggNOGⁱ	ENOG410IEG3 Eukaryota ENOG4110A16 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063867
HOGENOMⁱ	HOG000111497
HOVERGENⁱ	HBG097654
InParanoidⁱ	Q14140
OMAⁱ	DSLPGNF
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0F8L
PhylomeDBⁱ	Q14140
TreeFamⁱ	TF331620

Family and domain databases

InterProⁱ	View protein in InterPro IPR009263 SERTA_dom
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF06031 SERTA, 1 hit
PROSITEⁱ	View protein in PROSITE PS51053 SERTA, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q14140-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MLGKGGKRKF DEHEDGLEGK IVSPCDGPSK VSYTLQRQTI FNISLMKLYN 
        60         70         80         90        100
HRPLTEPSLQ KTVLINNMLR RIQEELKQEG SLRPMFTPSS QPTTEPSDSY 
       110        120        130        140        150
REAPPAFSHL ASPSSHPCDL GSTTPLEACL TPASLLEDDD DTFCTSQAMQ 
       160        170        180        190        200
PTAPTKLSPP ALLPEKDSFS SALDEIEELC PTSTSTEAAT AATDSVKGTS 
       210        220        230        240        250
SEAGTQKLDG PQESRADDSK LMDSLPGNFE ITTSTGFLTD LTLDDILFAD 
       260        270        280        290        300
IDTSMYDFDP CTSSSGTASK MAPVSADDLL KTLAPYSSQP VTPSQPFKMD 
       310 
LTELDHIMEV LVGS

Length:314

Mass (Da):33,897

Last modified:November 1, 1996 - v1

Checksum:ⁱE43107FC565AAC31

GO

Sequence cautionⁱ

The sequence BAA09476 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	D50917 mRNA Translation: BAA09476.2 Different initiation. AC007365 Genomic DNA Translation: AAY14766.1 BC074788 mRNA Translation: AAH74788.1 BC074789 mRNA Translation: AAH74789.1 BC101639 mRNA Translation: AAI01640.1 BC101641 mRNA Translation: AAI01642.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS33210.1
NCBI Reference Sequences More...RefSeqⁱ	NP_055570.1, NM_014755.2 XP_005264726.1, XM_005264669.2 XP_011531507.1, XM_011533205.2
UniGeneⁱ	Hs.591569 Hs.662573

Genome annotation databases

Ensemblⁱ	ENST00000313349; ENSP00000326933; ENSG00000179833
GeneIDⁱ	9792
KEGGⁱ	hsa:9792
UCSC genome browser More...UCSCⁱ	uc002sde.3 human

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
Q14140	UPI000809ED92		Cebus capucinus imitator		375
SERTA domain containing 2		GORGO		325
UPI00083BE435		RHIBE		321
SERTA domain containing 2		MACFA		320
SERTA domain-containing protein 2		CASCN		317
+24

Protein	Similar proteins		Species	Score	Length
Q14140	UPI000809ED92		Cebus capucinus imitator		375
SERTA domain containing 2		GORGO		325
UPI00083BE435		RHIBE		321
SERTA domain containing 2		MACFA		320
SERTA domain-containing protein 2		CASCN		317
+192

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	D50917 mRNA Translation: BAA09476.2 Different initiation. AC007365 Genomic DNA Translation: AAY14766.1 BC074788 mRNA Translation: AAH74788.1 BC074789 mRNA Translation: AAH74789.1 BC101639 mRNA Translation: AAI01640.1 BC101641 mRNA Translation: AAI01642.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS33210.1
NCBI Reference Sequences More...RefSeqⁱ	NP_055570.1, NM_014755.2 XP_005264726.1, XM_005264669.2 XP_011531507.1, XM_011533205.2
UniGeneⁱ	Hs.591569 Hs.662573

3D structure databases

ProteinModelPortalⁱ	Q14140
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	115136, 9 interactors
IntActⁱ	Q14140, 20 interactors

PTM databases

iPTMnetⁱ	Q14140
PhosphoSitePlusⁱ	Q14140

Polymorphism and mutation databases

BioMutaⁱ	SERTAD2
DMDMⁱ	3123047

Proteomic databases

PaxDbⁱ	Q14140
PeptideAtlas More...PeptideAtlasⁱ	Q14140
PRIDEⁱ	Q14140
ProteomicsDBⁱ	59842

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	9792
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000313349; ENSP00000326933; ENSG00000179833
GeneIDⁱ	9792
KEGGⁱ	hsa:9792
UCSC genome browser More...UCSCⁱ	uc002sde.3 human

Organism-specific databases

CTDⁱ	9792
DisGeNET More...DisGeNETⁱ	9792
EuPathDBⁱ	HostDB:ENSG00000179833.4
GeneCardsⁱ	SERTAD2
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:30784 SERTAD2
Human Protein Atlas More...HPAⁱ	HPA019021 HPA020904
MIMⁱ	617851 gene
neXtProtⁱ	NX_Q14140
Open Targets More...OpenTargetsⁱ	ENSG00000179833
PharmGKBⁱ	PA134948884
HUGEⁱ	Search...
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IEG3 Eukaryota ENOG4110A16 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063867
HOGENOMⁱ	HOG000111497
HOVERGENⁱ	HBG097654
InParanoidⁱ	Q14140
OMAⁱ	DSLPGNF
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0F8L
PhylomeDBⁱ	Q14140
TreeFamⁱ	TF331620

Miscellaneous databases

GenomeRNAiⁱ	9792
Protein Ontology More...PROⁱ	PR:Q14140
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000179833
CleanExⁱ	HS_SERTAD2
Genevisibleⁱ	Q14140 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR009263 SERTA_dom
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF06031 SERTA, 1 hit
PROSITEⁱ	View protein in PROSITE PS51053 SERTA, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SRTD2_HUMAN
Accessionⁱ	Q14140Primary (citable) accession number: Q14140 Secondary accession number(s): Q53TS2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
	Last sequence update:	November 1, 1996
	Last modified:	July 18, 2018
	This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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UniProtKB - Q14140 (SRTD2_HUMAN)

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SERTA domain-containing protein 2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Cytosol

Nucleus

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Motif

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ