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Entry version 201 (16 Oct 2019)
Sequence version 2 (10 Oct 2002)
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Protein

Ribosome biogenesis protein BOP1

Gene

BOP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.UniRule annotation2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processRibosome biogenesis, rRNA processing

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q14137

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ribosome biogenesis protein BOP1UniRule annotation
Alternative name(s):
Block of proliferation 1 proteinUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:BOP1UniRule annotation
Synonyms:KIAA0124
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:15519 BOP1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
610596 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q14137

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
23246

Open Targets

More...
OpenTargetsi
ENSG00000261236

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA25398

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q14137

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
BOP1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
23830903

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000508851 – 746Ribosome biogenesis protein BOP1Add BLAST746

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei106PhosphothreonineCombined sources1
Modified residuei122PhosphotyrosineCombined sources1
Modified residuei126PhosphoserineCombined sources1
Modified residuei127PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q14137

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q14137

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q14137

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q14137

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q14137

PeptideAtlas

More...
PeptideAtlasi
Q14137

PRoteomics IDEntifications database

More...
PRIDEi
Q14137

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
59839 [Q14137-1]
77815

2D gel databases

Two-dimensional polyacrylamide gel electrophoresis database from the Geneva University Hospital

More...
SWISS-2DPAGEi
Q14137

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q14137

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q14137

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q14137

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By MYC.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000261236 Expressed in 197 organ(s), highest expression level in right lobe of thyroid gland

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q14137 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q14137 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA047869
HPA066764

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the PeBoW complex, composed of BOP1, PES1 and WDR12 (PubMed:16043514, PubMed:16738141, PubMed:17189298, PubMed:17353269). The complex is held together by BOP1, which interacts with PES1 via its N-terminal domain and with WDR12 via a high-affinity interaction between the seven-bladed beta-propeller domains of the 2 proteins. The NOP7 complex associates with the 66S pre-ribosome (By similarity). The PeBoW complex associates with DDX27, BOP1 interacts directly with DDX27 (PubMed:25825154).

UniRule annotation5 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
116850, 70 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q14137

Protein interaction database and analysis system

More...
IntActi
Q14137, 28 interactors

Molecular INTeraction database

More...
MINTi
Q14137

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000455106

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q14137

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati411 – 450WD 1Add BLAST40
Repeati452 – 492WD 2Add BLAST41
Repeati532 – 576WD 3Add BLAST45
Repeati577 – 615WD 4Add BLAST39
Repeati618 – 657WD 5Add BLAST40
Repeati661 – 700WD 6Add BLAST40
Repeati716 – 746WD 7Add BLAST31

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni265 – 427Sufficient for nucleolar localizationBy similarityAdd BLAST163

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the WD repeat BOP1/ERB1 family.UniRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0650 Eukaryota
ENOG410XRBX LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000018422

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000029368

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q14137

KEGG Orthology (KO)

More...
KOi
K14824

Identification of Orthologs from Complete Genome Data

More...
OMAi
SHGMVYN

Database of Orthologous Groups

More...
OrthoDBi
759498at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q14137

TreeFam database of animal gene trees

More...
TreeFami
TF300437

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.130.10.10, 1 hit

HAMAP database of protein families

More...
HAMAPi
MF_03027 BOP1, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR028598 BOP1/Erb1
IPR012953 BOP1_N_dom
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR17605 PTHR17605, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08145 BOP1NT, 1 hit
PF00400 WD40, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01035 BOP1NT, 1 hit
SM00320 WD40, 7 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50978 SSF50978, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 2 hits
PS50294 WD_REPEATS_REGION, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q14137-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAGSRGAGRT AAPSVRPEKR RSEPELEPEP EPEPPLLCTS PLSHSTGSDS
60 70 80 90 100
GVSDSEESVF SGLEDSGSDS SEDDDEGDEE GEDGALDDEG HSGIKKTTEE
110 120 130 140 150
QVQASTPCPR TEMASARIGD EYAEDSSDEE DIRNTVGNVP LEWYDDFPHV
160 170 180 190 200
GYDLDGRRIY KPLRTRDELD QFLDKMDDPD YWRTVQDPMT GRDLRLTDEQ
210 220 230 240 250
VALVRRLQSG QFGDVGFNPY EPAVDFFSGD VMIHPVTNRP ADKRSFIPSL
260 270 280 290 300
VEKEKVSRMV HAIKMGWIQP RRPRDPTPSF YDLWAQEDPN AVLGRHKMHV
310 320 330 340 350
PAPKLALPGH AESYNPPPEY LLSEEERLAW EQQEPGERKL SFLPRKFPSL
360 370 380 390 400
RAVPAYGRFI QERFERCLDL YLCPRQRKMR VNVDPEDLIP KLPRPRDLQP
410 420 430 440 450
FPTCQALVYR GHSDLVRCLS VSPGGQWLVS GSDDGSLRLW EVATARCVRT
460 470 480 490 500
VPVGGVVKSV AWNPSPAVCL VAAAVEDSVL LLNPALGDRL VAGSTDQLLS
510 520 530 540 550
AFVPPEEPPL QPARWLEASE EERQVGLRLR ICHGKPVTQV TWHGRGDYLA
560 570 580 590 600
VVLATQGHTQ VLIHQLSRRR SQSPFRRSHG QVQRVAFHPA RPFLLVASQR
610 620 630 640 650
SVRLYHLLRQ ELTKKLMPNC KWVSSLAVHP AGDNVICGSY DSKLVWFDLD
660 670 680 690 700
LSTKPYRMLR HHKKALRAVA FHPRYPLFAS GSDDGSVIVC HGMVYNDLLQ
710 720 730 740
NPLLVPVKVL KGHVLTRDLG VLDVIFHPTQ PWVFSSGADG TVRLFT
Length:746
Mass (Da):83,630
Last modified:October 10, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i49A97BE21B0EB3DD
GO
Isoform 2 (identifier: Q14137-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-112: Missing.

Show »
Length:634
Mass (Da):71,930
Checksum:iE7A5608B28D65C36
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A075B729A0A075B729_HUMAN
Ribosome biogenesis protein BOP1
BOP1
217Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti577R → H in BAA09473 (PubMed:8590280).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0563911 – 112Missing in isoform 2. 1 PublicationAdd BLAST112

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB060694 mRNA Translation: BAB70666.1
AC145291 Genomic DNA No translation available.
AC231662 Genomic DNA No translation available.
BC001086 mRNA Translation: AAH01086.2
BC005160 mRNA Translation: AAH05160.2
BC007274 mRNA Translation: AAH07274.1
BC013787 mRNA Translation: AAH13787.1
BC013980 mRNA Translation: AAH13980.1
BC017674 mRNA Translation: AAH17674.1
D50914 mRNA Translation: BAA09473.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS6418.2 [Q14137-1]

NCBI Reference Sequences

More...
RefSeqi
NP_056016.1, NM_015201.4 [Q14137-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000569669; ENSP00000455106; ENSG00000261236 [Q14137-1]
ENST00000642409; ENSP00000495401; ENSG00000285301 [Q14137-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
23246

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:23246

UCSC genome browser

More...
UCSCi
uc033ccj.2 human [Q14137-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB060694 mRNA Translation: BAB70666.1
AC145291 Genomic DNA No translation available.
AC231662 Genomic DNA No translation available.
BC001086 mRNA Translation: AAH01086.2
BC005160 mRNA Translation: AAH05160.2
BC007274 mRNA Translation: AAH07274.1
BC013787 mRNA Translation: AAH13787.1
BC013980 mRNA Translation: AAH13980.1
BC017674 mRNA Translation: AAH17674.1
D50914 mRNA Translation: BAA09473.1
CCDSiCCDS6418.2 [Q14137-1]
RefSeqiNP_056016.1, NM_015201.4 [Q14137-1]

3D structure databases

SMRiQ14137
ModBaseiSearch...

Protein-protein interaction databases

BioGridi116850, 70 interactors
CORUMiQ14137
IntActiQ14137, 28 interactors
MINTiQ14137
STRINGi9606.ENSP00000455106

PTM databases

iPTMnetiQ14137
PhosphoSitePlusiQ14137
SwissPalmiQ14137

Polymorphism and mutation databases

BioMutaiBOP1
DMDMi23830903

2D gel databases

SWISS-2DPAGEiQ14137

Proteomic databases

EPDiQ14137
jPOSTiQ14137
MassIVEiQ14137
MaxQBiQ14137
PaxDbiQ14137
PeptideAtlasiQ14137
PRIDEiQ14137
ProteomicsDBi59839 [Q14137-1]
77815

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
23246

Genome annotation databases

EnsembliENST00000569669; ENSP00000455106; ENSG00000261236 [Q14137-1]
ENST00000642409; ENSP00000495401; ENSG00000285301 [Q14137-1]
GeneIDi23246
KEGGihsa:23246
UCSCiuc033ccj.2 human [Q14137-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23246
DisGeNETi23246

GeneCards: human genes, protein and diseases

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GeneCardsi
BOP1
HGNCiHGNC:15519 BOP1
HPAiHPA047869
HPA066764
MIMi610596 gene
neXtProtiNX_Q14137
OpenTargetsiENSG00000261236
PharmGKBiPA25398

Human Unidentified Gene-Encoded large proteins database

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HUGEi
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GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG0650 Eukaryota
ENOG410XRBX LUCA
GeneTreeiENSGT00390000018422
HOGENOMiHOG000029368
InParanoidiQ14137
KOiK14824
OMAiSHGMVYN
OrthoDBi759498at2759
PhylomeDBiQ14137
TreeFamiTF300437

Enzyme and pathway databases

ReactomeiR-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
SignaLinkiQ14137

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
BOP1 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
BOP1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
23246
PharosiQ14137

Protein Ontology

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PROi
PR:Q14137

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000261236 Expressed in 197 organ(s), highest expression level in right lobe of thyroid gland
ExpressionAtlasiQ14137 baseline and differential
GenevisibleiQ14137 HS

Family and domain databases

Gene3Di2.130.10.10, 1 hit
HAMAPiMF_03027 BOP1, 1 hit
InterProiView protein in InterPro
IPR028598 BOP1/Erb1
IPR012953 BOP1_N_dom
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR17605 PTHR17605, 1 hit
PfamiView protein in Pfam
PF08145 BOP1NT, 1 hit
PF00400 WD40, 3 hits
SMARTiView protein in SMART
SM01035 BOP1NT, 1 hit
SM00320 WD40, 7 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 2 hits
PS50294 WD_REPEATS_REGION, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiBOP1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q14137
Secondary accession number(s): Q969Z6
, Q96IS8, Q96Q25, Q9BSA7, Q9BVM0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: October 10, 2002
Last modified: October 16, 2019
This is version 201 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
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