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Protein

Ribosome biogenesis protein BOP1

Gene

BOP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.UniRule annotation2 Publications

GO - Molecular functioni

  • ribonucleoprotein complex binding Source: GO_Central
  • RNA binding Source: UniProtKB

GO - Biological processi

Keywordsi

Biological processRibosome biogenesis, rRNA processing

Enzyme and pathway databases

ReactomeiR-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
SignaLinkiQ14137

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosome biogenesis protein BOP1UniRule annotation
Alternative name(s):
Block of proliferation 1 proteinUniRule annotation
Gene namesi
Name:BOP1UniRule annotation
Synonyms:KIAA0124
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000261236.5
HGNCiHGNC:15519 BOP1
MIMi610596 gene
neXtProtiNX_Q14137

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi23246
OpenTargetsiENSG00000261236
PharmGKBiPA25398

Polymorphism and mutation databases

BioMutaiBOP1
DMDMi23830903

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000508851 – 746Ribosome biogenesis protein BOP1Add BLAST746

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei106PhosphothreonineCombined sources1
Modified residuei122PhosphotyrosineCombined sources1
Modified residuei126PhosphoserineCombined sources1
Modified residuei127PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ14137
MaxQBiQ14137
PaxDbiQ14137
PeptideAtlasiQ14137
PRIDEiQ14137
ProteomicsDBi59839

2D gel databases

SWISS-2DPAGEiQ14137

PTM databases

iPTMnetiQ14137
PhosphoSitePlusiQ14137
SwissPalmiQ14137

Expressioni

Inductioni

By MYC.1 Publication

Gene expression databases

BgeeiENSG00000261236 Expressed in 197 organ(s), highest expression level in right lobe of thyroid gland
CleanExiHS_BOP1
ExpressionAtlasiQ14137 baseline and differential
GenevisibleiQ14137 HS

Organism-specific databases

HPAiHPA047869
HPA066764

Interactioni

Subunit structurei

Component of the PeBoW complex, composed of BOP1, PES1 and WDR12 (PubMed:16043514, PubMed:16738141, PubMed:17189298, PubMed:17353269). The complex is held together by BOP1, which interacts with PES1 via its N-terminal domain and with WDR12 via a high-affinity interaction between the seven-bladed beta-propeller domains of the 2 proteins. The NOP7 complex associates with the 66S pre-ribosome (By similarity). The PeBoW complex associates with DDX27, BOP1 interacts directly with DDX27 (PubMed:25825154).UniRule annotation5 Publications

Binary interactionsi

Protein-protein interaction databases

BioGridi116850, 59 interactors
CORUMiQ14137
IntActiQ14137, 17 interactors
MINTiQ14137
STRINGi9606.ENSP00000304151

Structurei

3D structure databases

ProteinModelPortaliQ14137
SMRiQ14137
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati411 – 450WD 1Add BLAST40
Repeati452 – 492WD 2Add BLAST41
Repeati532 – 576WD 3Add BLAST45
Repeati577 – 615WD 4Add BLAST39
Repeati618 – 657WD 5Add BLAST40
Repeati661 – 700WD 6Add BLAST40
Repeati716 – 746WD 7Add BLAST31

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni265 – 427Sufficient for nucleolar localizationBy similarityAdd BLAST163

Sequence similaritiesi

Belongs to the WD repeat BOP1/ERB1 family.UniRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0650 Eukaryota
ENOG410XRBX LUCA
GeneTreeiENSGT00390000018422
HOGENOMiHOG000029368
HOVERGENiHBG008113
InParanoidiQ14137
KOiK14824
OMAiSHGMVYN
OrthoDBiEOG091G0389
PhylomeDBiQ14137
TreeFamiTF300437

Family and domain databases

Gene3Di2.130.10.10, 1 hit
HAMAPiMF_03027 BOP1, 1 hit
InterProiView protein in InterPro
IPR028598 BOP1/Erb1
IPR012953 BOP1_N_dom
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR17605 PTHR17605, 1 hit
PfamiView protein in Pfam
PF08145 BOP1NT, 1 hit
PF00400 WD40, 3 hits
SMARTiView protein in SMART
SM01035 BOP1NT, 1 hit
SM00320 WD40, 7 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 2 hits
PS50294 WD_REPEATS_REGION, 2 hits

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q14137-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAGSRGAGRT AAPSVRPEKR RSEPELEPEP EPEPPLLCTS PLSHSTGSDS
60 70 80 90 100
GVSDSEESVF SGLEDSGSDS SEDDDEGDEE GEDGALDDEG HSGIKKTTEE
110 120 130 140 150
QVQASTPCPR TEMASARIGD EYAEDSSDEE DIRNTVGNVP LEWYDDFPHV
160 170 180 190 200
GYDLDGRRIY KPLRTRDELD QFLDKMDDPD YWRTVQDPMT GRDLRLTDEQ
210 220 230 240 250
VALVRRLQSG QFGDVGFNPY EPAVDFFSGD VMIHPVTNRP ADKRSFIPSL
260 270 280 290 300
VEKEKVSRMV HAIKMGWIQP RRPRDPTPSF YDLWAQEDPN AVLGRHKMHV
310 320 330 340 350
PAPKLALPGH AESYNPPPEY LLSEEERLAW EQQEPGERKL SFLPRKFPSL
360 370 380 390 400
RAVPAYGRFI QERFERCLDL YLCPRQRKMR VNVDPEDLIP KLPRPRDLQP
410 420 430 440 450
FPTCQALVYR GHSDLVRCLS VSPGGQWLVS GSDDGSLRLW EVATARCVRT
460 470 480 490 500
VPVGGVVKSV AWNPSPAVCL VAAAVEDSVL LLNPALGDRL VAGSTDQLLS
510 520 530 540 550
AFVPPEEPPL QPARWLEASE EERQVGLRLR ICHGKPVTQV TWHGRGDYLA
560 570 580 590 600
VVLATQGHTQ VLIHQLSRRR SQSPFRRSHG QVQRVAFHPA RPFLLVASQR
610 620 630 640 650
SVRLYHLLRQ ELTKKLMPNC KWVSSLAVHP AGDNVICGSY DSKLVWFDLD
660 670 680 690 700
LSTKPYRMLR HHKKALRAVA FHPRYPLFAS GSDDGSVIVC HGMVYNDLLQ
710 720 730 740
NPLLVPVKVL KGHVLTRDLG VLDVIFHPTQ PWVFSSGADG TVRLFT
Length:746
Mass (Da):83,630
Last modified:October 10, 2002 - v2
Checksum:i49A97BE21B0EB3DD
GO
Isoform 2 (identifier: Q14137-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-112: Missing.

Show »
Length:634
Mass (Da):71,930
Checksum:iE7A5608B28D65C36
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A075B729A0A075B729_HUMAN
Ribosome biogenesis protein BOP1
BOP1
217Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti577R → H in BAA09473 (PubMed:8590280).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0563911 – 112Missing in isoform 2. 1 PublicationAdd BLAST112

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB060694 mRNA Translation: BAB70666.1
AC145291 Genomic DNA No translation available.
AC231662 Genomic DNA No translation available.
BC001086 mRNA Translation: AAH01086.2
BC005160 mRNA Translation: AAH05160.2
BC007274 mRNA Translation: AAH07274.1
BC013787 mRNA Translation: AAH13787.1
BC013980 mRNA Translation: AAH13980.1
BC017674 mRNA Translation: AAH17674.1
D50914 mRNA Translation: BAA09473.1
CCDSiCCDS6418.2 [Q14137-1]
RefSeqiNP_056016.1, NM_015201.4 [Q14137-1]
UniGeneiHs.535901
Hs.645279

Genome annotation databases

EnsembliENST00000569669; ENSP00000455106; ENSG00000261236 [Q14137-1]
ENST00000642409; ENSP00000495401; ENSG00000285301 [Q14137-1]
GeneIDi23246
KEGGihsa:23246
UCSCiuc033ccj.2 human [Q14137-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB060694 mRNA Translation: BAB70666.1
AC145291 Genomic DNA No translation available.
AC231662 Genomic DNA No translation available.
BC001086 mRNA Translation: AAH01086.2
BC005160 mRNA Translation: AAH05160.2
BC007274 mRNA Translation: AAH07274.1
BC013787 mRNA Translation: AAH13787.1
BC013980 mRNA Translation: AAH13980.1
BC017674 mRNA Translation: AAH17674.1
D50914 mRNA Translation: BAA09473.1
CCDSiCCDS6418.2 [Q14137-1]
RefSeqiNP_056016.1, NM_015201.4 [Q14137-1]
UniGeneiHs.535901
Hs.645279

3D structure databases

ProteinModelPortaliQ14137
SMRiQ14137
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116850, 59 interactors
CORUMiQ14137
IntActiQ14137, 17 interactors
MINTiQ14137
STRINGi9606.ENSP00000304151

PTM databases

iPTMnetiQ14137
PhosphoSitePlusiQ14137
SwissPalmiQ14137

Polymorphism and mutation databases

BioMutaiBOP1
DMDMi23830903

2D gel databases

SWISS-2DPAGEiQ14137

Proteomic databases

EPDiQ14137
MaxQBiQ14137
PaxDbiQ14137
PeptideAtlasiQ14137
PRIDEiQ14137
ProteomicsDBi59839

Protocols and materials databases

DNASUi23246
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000569669; ENSP00000455106; ENSG00000261236 [Q14137-1]
ENST00000642409; ENSP00000495401; ENSG00000285301 [Q14137-1]
GeneIDi23246
KEGGihsa:23246
UCSCiuc033ccj.2 human [Q14137-1]

Organism-specific databases

CTDi23246
DisGeNETi23246
EuPathDBiHostDB:ENSG00000261236.5
GeneCardsiBOP1
H-InvDBiHIX0168814
HGNCiHGNC:15519 BOP1
HPAiHPA047869
HPA066764
MIMi610596 gene
neXtProtiNX_Q14137
OpenTargetsiENSG00000261236
PharmGKBiPA25398
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0650 Eukaryota
ENOG410XRBX LUCA
GeneTreeiENSGT00390000018422
HOGENOMiHOG000029368
HOVERGENiHBG008113
InParanoidiQ14137
KOiK14824
OMAiSHGMVYN
OrthoDBiEOG091G0389
PhylomeDBiQ14137
TreeFamiTF300437

Enzyme and pathway databases

ReactomeiR-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
SignaLinkiQ14137

Miscellaneous databases

ChiTaRSiBOP1 human
GeneWikiiBOP1
GenomeRNAii23246
PROiPR:Q14137
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000261236 Expressed in 197 organ(s), highest expression level in right lobe of thyroid gland
CleanExiHS_BOP1
ExpressionAtlasiQ14137 baseline and differential
GenevisibleiQ14137 HS

Family and domain databases

Gene3Di2.130.10.10, 1 hit
HAMAPiMF_03027 BOP1, 1 hit
InterProiView protein in InterPro
IPR028598 BOP1/Erb1
IPR012953 BOP1_N_dom
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR17605 PTHR17605, 1 hit
PfamiView protein in Pfam
PF08145 BOP1NT, 1 hit
PF00400 WD40, 3 hits
SMARTiView protein in SMART
SM01035 BOP1NT, 1 hit
SM00320 WD40, 7 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 2 hits
PS50294 WD_REPEATS_REGION, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiBOP1_HUMAN
AccessioniPrimary (citable) accession number: Q14137
Secondary accession number(s): Q969Z6
, Q96IS8, Q96Q25, Q9BSA7, Q9BVM0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: October 10, 2002
Last modified: November 7, 2018
This is version 193 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
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