Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 146 (18 Sep 2019)
Sequence version 4 (21 Jun 2005)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Transcription cofactor vestigial-like protein 4

Gene

VGLL4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May act as a specific coactivator for the mammalian TEFs.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTranscription, Transcription regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transcription cofactor vestigial-like protein 4
Short name:
Vgl-4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:VGLL4
Synonyms:KIAA0121
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:28966 VGLL4

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q14135

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
9686

Open Targets

More...
OpenTargetsi
ENSG00000144560

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA128394553

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
VGLL4

Domain mapping of disease mutations (DMDM)

More...
DMDMi
68068037

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001913511 – 290Transcription cofactor vestigial-like protein 4Add BLAST290

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
Modified residuei52PhosphoserineCombined sources1
Modified residuei149PhosphoserineCombined sources1
Modified residuei153PhosphothreonineCombined sources1
Modified residuei274PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q14135

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q14135

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q14135

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q14135

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q14135

PeptideAtlas

More...
PeptideAtlasi
Q14135

PRoteomics IDEntifications database

More...
PRIDEi
Q14135

ProteomicsDB human proteome resource

More...
ProteomicsDBi
59833 [Q14135-1]
59834 [Q14135-2]
59835 [Q14135-3]
59836 [Q14135-4]
59837 [Q14135-5]
59838 [Q14135-6]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q14135

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q14135

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000144560 Expressed in 236 organ(s), highest expression level in oviduct epithelium

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q14135 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q14135 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA038225
HPA038614

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with TEFs (By similarity).

Interacts with IRF2BP2.

By similarity1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
115039, 19 interactors

Protein interaction database and analysis system

More...
IntActi
Q14135, 16 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000404251

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q14135

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the vestigial family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IFGD Eukaryota
ENOG410XX71 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000003282

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000290700

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q14135

Database of Orthologous Groups

More...
OrthoDBi
1275581at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q14135

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006627 TDU_repeat
IPR028184 VGLL4

The PANTHER Classification System

More...
PANTHERi
PTHR17604 PTHR17604, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15245 VGLL4, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00711 TDU, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 6 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 14 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q14135-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
METPLDVLSR AASLVHADDE KREAALRGEP RMQTLPVASA LSSHRTGPPP
60 70 80 90 100
ISPSKRKFSM EPGDEDLDCD NDHVSKMSRI FNPHLNKTAN GDCRRDPRER
110 120 130 140 150
SRSPIERAVA PTMSLHGSHL YTSLPSLGLE QPLALTKNSL DASRPAGLSP
160 170 180 190 200
TLTPGERQQN RPSVITCASA GARNCNLSHC PIAHSGCAAP GPASYRRPPS
210 220 230 240 250
AATTCDPVVE EHFRRSLGKN YKEPEPAPNS VSITGSVDDH FAKALGDTWL
260 270 280 290
QIKAAKDGAS SSPESASRRG QPASPSAHMV SHSHSPSVVS
Length:290
Mass (Da):30,948
Last modified:June 21, 2005 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA5EA4C167CC8F0B4
GO
Isoform 2 (identifier: Q14135-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-31: Missing.

Show »
Length:259
Mass (Da):27,532
Checksum:i5FA3C906694B6801
GO
Isoform 3 (identifier: Q14135-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     22-41: REAALRGEPRMQTLPVASAL → PSPGNLLEMQNRSPRCGTDD
     42-290: Missing.

Note: Probable target of nonsense-mediated mRNA decay.
Show »
Length:41
Mass (Da):4,467
Checksum:iE2D1E5A12429DEC6
GO
Isoform 4 (identifier: Q14135-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-22: METPLDVLSRAASLVHADDEKR → MLFMKMDLLNYQYLDKMNNNIGILCYEG

Show »
Length:296
Mass (Da):31,883
Checksum:iDFA06E193A0EBF56
GO
Isoform 5 (identifier: Q14135-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-84: Missing.
     85-85: L → M

Show »
Length:206
Mass (Da):21,705
Checksum:i3B2999D263D25A12
GO
Isoform 6 (identifier: Q14135-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-80: Missing.
     81-85: FNPHL → MIKVR

Show »
Length:210
Mass (Da):22,202
Checksum:i69F674B9C9D8D9EE
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 14 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A075B6E4A0A075B6E4_HUMAN
Transcription cofactor vestigial-li...
VGLL4
290Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G5E9M7G5E9M7_HUMAN
Transcription cofactor vestigial-li...
VGLL4 hCG_1777277
296Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G5E9M9G5E9M9_HUMAN
Transcription cofactor vestigial-li...
VGLL4 hCG_1777277
231Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A6YYI5A0A0A6YYI5_HUMAN
Transcription cofactor vestigial-li...
VGLL4 hCG_1777277
295Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JBN2C9JBN2_HUMAN
Transcription cofactor vestigial-li...
VGLL4
81Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7ERW0E7ERW0_HUMAN
Transcription cofactor vestigial-li...
VGLL4
190Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EUJ2E7EUJ2_HUMAN
Transcription cofactor vestigial-li...
VGLL4
127Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EWF5E7EWF5_HUMAN
Transcription cofactor vestigial-li...
VGLL4
223Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8W708F8W708_HUMAN
Transcription cofactor vestigial-li...
VGLL4
169Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JX59C9JX59_HUMAN
Transcription cofactor vestigial-li...
VGLL4
60Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH03038 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated
The sequence BAA09470 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02468932M → I2 PublicationsCorresponds to variant dbSNP:rs2276749Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0402101 – 84Missing in isoform 5. 1 PublicationAdd BLAST84
Alternative sequenceiVSP_0402111 – 80Missing in isoform 6. 1 PublicationAdd BLAST80
Alternative sequenceiVSP_0107761 – 31Missing in isoform 2. 1 PublicationAdd BLAST31
Alternative sequenceiVSP_0402121 – 22METPL…DDEKR → MLFMKMDLLNYQYLDKMNNN IGILCYEG in isoform 4. 1 PublicationAdd BLAST22
Alternative sequenceiVSP_04021322 – 41REAAL…VASAL → PSPGNLLEMQNRSPRCGTDD in isoform 3. 1 PublicationAdd BLAST20
Alternative sequenceiVSP_04021442 – 290Missing in isoform 3. 1 PublicationAdd BLAST249
Alternative sequenceiVSP_04021581 – 85FNPHL → MIKVR in isoform 6. 1 Publication5
Alternative sequenceiVSP_04021685L → M in isoform 5. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
D50911 mRNA Translation: BAA09470.3 Different initiation.
AK130542 mRNA Translation: BAC85375.1
AK300344 mRNA Translation: BAG62089.1
AK307708 mRNA No translation available.
AK308761 mRNA No translation available.
DA770257 mRNA No translation available.
AC022001 Genomic DNA No translation available.
AC090939 Genomic DNA No translation available.
CH471055 Genomic DNA Translation: EAW64104.1
BC001514 mRNA Translation: AAH01514.2
BC003038 mRNA Translation: AAH03038.1 Sequence problems.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS2606.1 [Q14135-1]
CCDS46754.1 [Q14135-4]
CCDS46755.1 [Q14135-6]
CCDS46756.1 [Q14135-5]

NCBI Reference Sequences

More...
RefSeqi
NP_001121691.1, NM_001128219.2
NP_001121692.1, NM_001128220.2 [Q14135-6]
NP_001121693.1, NM_001128221.2 [Q14135-5]
NP_001271319.1, NM_001284390.1
NP_001271320.1, NM_001284391.1
NP_055482.2, NM_014667.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000424529; ENSP00000402878; ENSG00000144560 [Q14135-5]
ENST00000451674; ENSP00000416615; ENSG00000144560 [Q14135-6]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
9686

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:9686

UCSC genome browser

More...
UCSCi
uc010hdv.3 human [Q14135-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50911 mRNA Translation: BAA09470.3 Different initiation.
AK130542 mRNA Translation: BAC85375.1
AK300344 mRNA Translation: BAG62089.1
AK307708 mRNA No translation available.
AK308761 mRNA No translation available.
DA770257 mRNA No translation available.
AC022001 Genomic DNA No translation available.
AC090939 Genomic DNA No translation available.
CH471055 Genomic DNA Translation: EAW64104.1
BC001514 mRNA Translation: AAH01514.2
BC003038 mRNA Translation: AAH03038.1 Sequence problems.
CCDSiCCDS2606.1 [Q14135-1]
CCDS46754.1 [Q14135-4]
CCDS46755.1 [Q14135-6]
CCDS46756.1 [Q14135-5]
RefSeqiNP_001121691.1, NM_001128219.2
NP_001121692.1, NM_001128220.2 [Q14135-6]
NP_001121693.1, NM_001128221.2 [Q14135-5]
NP_001271319.1, NM_001284390.1
NP_001271320.1, NM_001284391.1
NP_055482.2, NM_014667.3

3D structure databases

SMRiQ14135
ModBaseiSearch...

Protein-protein interaction databases

BioGridi115039, 19 interactors
IntActiQ14135, 16 interactors
STRINGi9606.ENSP00000404251

PTM databases

iPTMnetiQ14135
PhosphoSitePlusiQ14135

Polymorphism and mutation databases

BioMutaiVGLL4
DMDMi68068037

Proteomic databases

EPDiQ14135
jPOSTiQ14135
MassIVEiQ14135
MaxQBiQ14135
PaxDbiQ14135
PeptideAtlasiQ14135
PRIDEiQ14135
ProteomicsDBi59833 [Q14135-1]
59834 [Q14135-2]
59835 [Q14135-3]
59836 [Q14135-4]
59837 [Q14135-5]
59838 [Q14135-6]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
9686
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000424529; ENSP00000402878; ENSG00000144560 [Q14135-5]
ENST00000451674; ENSP00000416615; ENSG00000144560 [Q14135-6]
GeneIDi9686
KEGGihsa:9686
UCSCiuc010hdv.3 human [Q14135-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9686
DisGeNETi9686

GeneCards: human genes, protein and diseases

More...
GeneCardsi
VGLL4
HGNCiHGNC:28966 VGLL4
HPAiHPA038225
HPA038614
neXtProtiNX_Q14135
OpenTargetsiENSG00000144560
PharmGKBiPA128394553

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IFGD Eukaryota
ENOG410XX71 LUCA
GeneTreeiENSGT00390000003282
HOGENOMiHOG000290700
InParanoidiQ14135
OrthoDBi1275581at2759
PhylomeDBiQ14135

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
VGLL4 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
9686

Pharos

More...
Pharosi
Q14135

Protein Ontology

More...
PROi
PR:Q14135

Gene expression databases

BgeeiENSG00000144560 Expressed in 236 organ(s), highest expression level in oviduct epithelium
ExpressionAtlasiQ14135 baseline and differential
GenevisibleiQ14135 HS

Family and domain databases

InterProiView protein in InterPro
IPR006627 TDU_repeat
IPR028184 VGLL4
PANTHERiPTHR17604 PTHR17604, 1 hit
PfamiView protein in Pfam
PF15245 VGLL4, 1 hit
SMARTiView protein in SMART
SM00711 TDU, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiVGLL4_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q14135
Secondary accession number(s): B4DTS7
, J3KN68, Q7L5V0, Q9BQ78
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: June 21, 2005
Last modified: September 18, 2019
This is version 146 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again