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Protein

Tripartite motif-containing protein 29

Gene

TRIM29

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a crucial role in the regulation of macrophage activation in response to viral or bacterial infections within the respiratory tract. Mechanistically, TRIM29 interacts with IKBKG/NEMO in the lysosome where it induces its 'Lys-48' ubiquitination and subsequent degradation. In turn, the expression of type I interferons and the production of proinflammatory cytokines are inhibited. Additionally, induces the 'Lys-48' ubiquitination of TMEM173/STING in a similar way, leading to its degradation.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri220 – 260B box-typePROSITE-ProRule annotationAdd BLAST41

GO - Molecular functioni

  • cadherin binding involved in cell-cell adhesion Source: BHF-UCL
  • DNA-binding transcription factor activity Source: ProtInc
  • identical protein binding Source: IntAct
  • p53 binding Source: Ensembl
  • zinc ion binding Source: InterPro

GO - Biological processi

Keywordsi

Biological processImmunity, Innate immunity
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-877300 Interferon gamma signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Tripartite motif-containing protein 29
Alternative name(s):
Ataxia telangiectasia group D-associated protein
Gene namesi
Name:TRIM29
Synonyms:ATDC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000137699.16
HGNCiHGNC:17274 TRIM29
MIMi610658 gene
neXtProtiNX_Q14134

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Lysosome

Pathology & Biotechi

Organism-specific databases

DisGeNETi23650
OpenTargetsiENSG00000137699
PharmGKBiPA38218

Polymorphism and mutation databases

BioMutaiTRIM29
DMDMi116242825

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000562421 – 588Tripartite motif-containing protein 29Add BLAST588

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei21PhosphoserineCombined sources1
Modified residuei28PhosphoserineCombined sources1
Modified residuei58PhosphoserineCombined sources1
Modified residuei104PhosphoserineCombined sources1
Modified residuei106PhosphotyrosineCombined sources1
Modified residuei476PhosphothreonineCombined sources1
Modified residuei489PhosphoserineCombined sources1

Post-translational modificationi

Constitutively phosphorylated by PKC on serine/threonine in A431 cells.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ14134
MaxQBiQ14134
PaxDbiQ14134
PeptideAtlasiQ14134
PRIDEiQ14134
ProteomicsDBi59831
59832 [Q14134-2]

PTM databases

iPTMnetiQ14134
PhosphoSitePlusiQ14134

Expressioni

Tissue specificityi

Expressed in placenta, prostate and thymus.1 Publication

Gene expression databases

BgeeiENSG00000137699 Expressed in 158 organ(s), highest expression level in esophagus mucosa
CleanExiHS_TRIM29
ExpressionAtlasiQ14134 baseline and differential
GenevisibleiQ14134 HS

Organism-specific databases

HPAiHPA020053

Interactioni

Subunit structurei

Interacts with VIM and HINT1 (PubMed:7644499). Interacts with IKBKG/NEMO (PubMed:27695001). Interacts with TMEM173/STING (PubMed:29038422).3 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi117177, 115 interactors
IntActiQ14134, 53 interactors
MINTiQ14134
STRINGi9606.ENSP00000343129

Structurei

Secondary structure

1588
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ14134
SMRiQ14134
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ14134

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili259 – 352Sequence analysisAdd BLAST94

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri220 – 260B box-typePROSITE-ProRule annotationAdd BLAST41

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IK88 Eukaryota
ENOG410YEFV LUCA
GeneTreeiENSGT00760000118995
HOGENOMiHOG000154677
HOVERGENiHBG061597
InParanoidiQ14134
KOiK12010
OMAiCMRHVEK
OrthoDBiEOG091G056X
PhylomeDBiQ14134
TreeFamiTF351086

Family and domain databases

CDDicd00021 BBOX, 1 hit
InterProiView protein in InterPro
IPR000315 Znf_B-box
PfamiView protein in Pfam
PF00643 zf-B_box, 1 hit
SMARTiView protein in SMART
SM00336 BBOX, 1 hit
PROSITEiView protein in PROSITE
PS50119 ZF_BBOX, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 10 potential isoforms that are computationally mapped.iShow all

Isoform Alpha (identifier: Q14134-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEAADASRSN GSSPEARDAR SPSGPSGSLE NGTKADGKDA KTTNGHGGEA
60 70 80 90 100
AEGKSLGSAL KPGEGRSALF AGNEWRRPII QFVESGDDKN SNYFSMDSME
110 120 130 140 150
GKRSPYAGLQ LGAAKKPPVT FAEKGELRKS IFSESRKPTV SIMEPGETRR
160 170 180 190 200
NSYPRADTGL FSRSKSGSEE VLCDSCIGNK QKAVKSCLVC QASFCELHLK
210 220 230 240 250
PHLEGAAFRD HQLLEPIRDF EARKCPVHGK TMELFCQTDQ TCICYLCMFQ
260 270 280 290 300
EHKNHSTVTV EEAKAEKETE LSLQKEQLQL KIIEIEDEAE KWQKEKDRIK
310 320 330 340 350
SFTTNEKAIL EQNFRDLVRD LEKQKEEVRA ALEQREQDAV DQVKVIMDAL
360 370 380 390 400
DERAKVLHED KQTREQLHSI SDSVLFLQEF GALMSNYSLP PPLPTYHVLL
410 420 430 440 450
EGEGLGQSLG NFKDDLLNVC MRHVEKMCKA DLSRNFIERN HMENGGDHRY
460 470 480 490 500
VNNYTNSFGG EWSAPDTMKR YSMYLTPKGG VRTSYQPSSP GRFTKETTQK
510 520 530 540 550
NFNNLYGTKG NYTSRVWEYS SSIQNSDNDL PVVQGSSSFS LKGYPSLMRS
560 570 580
QSPKAQPQTW KSGKQTMLSH YRPFYVNKGN GIGSNEAP
Length:588
Mass (Da):65,835
Last modified:October 17, 2006 - v2
Checksum:i7CBAD7A4C43A311C
GO
Isoform Beta (identifier: Q14134-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     569-588: SHYRPFYVNKGNGIGSNEAP → VV

Note: No experimental confirmation available.
Show »
Length:570
Mass (Da):63,844
Checksum:iD5A14625B49E5FAC
GO

Computationally mapped potential isoform sequencesi

There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PRL4E9PRL4_HUMAN
Tripartite motif-containing protein...
TRIM29
327Annotation score:
E9PIQ2E9PIQ2_HUMAN
Tripartite motif-containing protein...
TRIM29
121Annotation score:
H0YD78H0YD78_HUMAN
Tripartite motif-containing protein...
TRIM29
119Annotation score:
E9PLI4E9PLI4_HUMAN
Tripartite motif-containing protein...
TRIM29
95Annotation score:
E9PJ94E9PJ94_HUMAN
Tripartite motif-containing protein...
TRIM29
97Annotation score:
E9PI31E9PI31_HUMAN
Tripartite motif-containing protein...
TRIM29
89Annotation score:
E9PJD4E9PJD4_HUMAN
Tripartite motif-containing protein...
TRIM29
169Annotation score:
E9PPX1E9PPX1_HUMAN
Tripartite motif-containing protein...
TRIM29
94Annotation score:
E9PM74E9PM74_HUMAN
Tripartite motif-containing protein...
TRIM29
38Annotation score:
H0YF27H0YF27_HUMAN
Tripartite motif-containing protein...
TRIM29
169Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti126 – 127EL → DV (PubMed:8188213).Curated2
Sequence conflicti126 – 127EL → DV (PubMed:11331580).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_035962514S → F in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs112973609Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_011999569 – 588SHYRP…SNEAP → VV in isoform Beta. 1 PublicationAdd BLAST20

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L24203 mRNA Translation: AAA35762.1
AF230388 mRNA Translation: AAG50167.1
AF230389 mRNA Translation: AAG50168.1
BC017352 mRNA Translation: AAH17352.1
CCDSiCCDS8428.1 [Q14134-1]
PIRiA49618
RefSeqiNP_036233.2, NM_012101.3 [Q14134-1]
UniGeneiHs.504115

Genome annotation databases

EnsembliENST00000341846; ENSP00000343129; ENSG00000137699 [Q14134-1]
GeneIDi23650
KEGGihsa:23650
UCSCiuc001pwz.4 human [Q14134-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiTRI29_HUMAN
AccessioniPrimary (citable) accession number: Q14134
Secondary accession number(s): Q96AA9, Q9BZY7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: October 17, 2006
Last modified: September 12, 2018
This is version 169 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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