UniProtKB - Q14126 (DSG2_HUMAN)
Protein
Desmoglein-2
Gene
DSG2
Organism
Homo sapiens (Human)
Status
Functioni
Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
GO - Molecular functioni
- calcium ion binding Source: GO_Central
- cell adhesion molecule binding Source: BHF-UCL
- cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication Source: BHF-UCL
GO - Biological processi
- bundle of His cell-Purkinje myocyte adhesion involved in cell communication Source: BHF-UCL
- cell adhesion Source: UniProtKB
- cell-cell adhesion Source: GO_Central
- cornification Source: Reactome
- desmosome organization Source: BHF-UCL
- homophilic cell adhesion via plasma membrane adhesion molecules Source: BHF-UCL
- keratinization Source: Reactome
- maternal process involved in female pregnancy Source: Ensembl
- Purkinje myocyte development Source: BHF-UCL
- regulation of heart rate by cardiac conduction Source: BHF-UCL
- regulation of ventricular cardiac muscle cell action potential Source: BHF-UCL
- response to progesterone Source: Ensembl
Keywordsi
Biological process | Cell adhesion |
Ligand | Calcium, Metal-binding |
Enzyme and pathway databases
PathwayCommonsi | Q14126 |
Reactomei | R-HSA-351906, Apoptotic cleavage of cell adhesion proteins R-HSA-6805567, Keratinization R-HSA-6809371, Formation of the cornified envelope |
Names & Taxonomyi
Protein namesi | Recommended name: Desmoglein-2Alternative name(s): Cadherin family member 5 HDGC |
Gene namesi | Name:DSG2 Synonyms:CDHF5 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:3049, DSG2 |
MIMi | 125671, gene |
neXtProti | NX_Q14126 |
VEuPathDBi | HostDB:ENSG00000046604.12 |
Subcellular locationi
Plasma membrane
Other locations
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Plasma Membrane
- apical plasma membrane Source: Ensembl
- cornified envelope Source: Reactome
- lateral plasma membrane Source: Ensembl
- plasma membrane Source: UniProtKB
Other locations
- cell junction Source: HPA
- cell surface Source: UniProtKB
- cell-cell junction Source: GO_Central
- desmosome Source: BHF-UCL
- integral component of membrane Source: UniProtKB-KW
- intercalated disc Source: BHF-UCL
- intracellular membrane-bounded organelle Source: HPA
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 50 – 609 | ExtracellularSequence analysisAdd BLAST | 560 | |
Transmembranei | 610 – 634 | HelicalSequence analysisAdd BLAST | 25 | |
Topological domaini | 635 – 1118 | CytoplasmicSequence analysisAdd BLAST | 484 |
Keywords - Cellular componenti
Cell junction, Cell membrane, MembranePathology & Biotechi
Involvement in diseasei
Arrhythmogenic right ventricular dysplasia, familial, 10 (ARVD10)4 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA congenital heart disease characterized by infiltration of adipose and fibrous tissue into the right ventricle and loss of myocardial cells, resulting in ventricular and supraventricular arrhythmias.
Related information in OMIMFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_029365 | 46 | R → Q in ARVD10. 2 PublicationsCorresponds to variant dbSNP:rs121913008EnsemblClinVar. | 1 | |
Natural variantiVAR_029366 | 49 | R → H in ARVD10. 4 PublicationsCorresponds to variant dbSNP:rs121913006EnsemblClinVar. | 1 | |
Natural variantiVAR_065686 | 335 | T → A in ARVD10. 1 PublicationCorresponds to variant dbSNP:rs191564916EnsemblClinVar. | 1 | |
Natural variantiVAR_029367 | 507 | C → Y in ARVD10. 2 PublicationsCorresponds to variant dbSNP:rs121913009EnsemblClinVar. | 1 | |
Natural variantiVAR_029368 | 812 | G → C in ARVD10. 2 PublicationsCorresponds to variant dbSNP:rs121913010EnsemblClinVar. | 1 |
Cardiomyopathy, dilated 1BB (CMD1BB)1 Publication
Disease susceptibility is associated with variants affecting the gene represented in this entry.
Disease descriptionA disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
Related information in OMIMKeywords - Diseasei
Cardiomyopathy, Disease variantOrganism-specific databases
DisGeNETi | 1829 |
GeneReviewsi | DSG2 |
MalaCardsi | DSG2 |
MIMi | 610193, phenotype 612877, phenotype |
OpenTargetsi | ENSG00000046604 |
Orphaneti | 293899, Familial isolated arrhythmogenic ventricular dysplasia, biventricular form 293888, Familial isolated arrhythmogenic ventricular dysplasia, left dominant form 293910, Familial isolated arrhythmogenic ventricular dysplasia, right dominant form 154, Familial isolated dilated cardiomyopathy |
PharmGKBi | PA27502 |
Miscellaneous databases
Pharosi | Q14126, Tbio |
Genetic variation databases
BioMutai | DSG2 |
DMDMi | 148876773 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 23 | Sequence analysisAdd BLAST | 23 | |
PropeptideiPRO_0000003845 | 24 – 49 | Sequence analysisAdd BLAST | 26 | |
ChainiPRO_0000003846 | 50 – 1118 | Desmoglein-2Add BLAST | 1069 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 112 | N-linked (GlcNAc...) asparagine2 Publications | 1 | |
Glycosylationi | 182 | N-linked (GlcNAc...) asparagine3 Publications | 1 | |
Glycosylationi | 309 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 462 | N-linked (GlcNAc...) (complex) asparagine2 Publications | 1 | |
Glycosylationi | 514 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 680 | PhosphoserineCombined sources | 1 | |
Modified residuei | 700 | PhosphoserineCombined sources | 1 | |
Modified residuei | 703 | PhosphoserineCombined sources | 1 | |
Modified residuei | 723 | PhosphoserineCombined sources | 1 | |
Modified residuei | 726 | PhosphoserineCombined sources | 1 | |
Modified residuei | 804 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 806 | PhosphoserineCombined sources | 1 | |
Modified residuei | 810 | PhosphoserineCombined sources | 1 | |
Modified residuei | 815 | PhosphoserineCombined sources | 1 | |
Modified residuei | 922 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 1118 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Cleavage on pair of basic residues, Glycoprotein, PhosphoproteinProteomic databases
CPTACi | CPTAC-1307 |
EPDi | Q14126 |
jPOSTi | Q14126 |
MassIVEi | Q14126 |
MaxQBi | Q14126 |
PaxDbi | Q14126 |
PeptideAtlasi | Q14126 |
PRIDEi | Q14126 |
ProteomicsDBi | 59829 |
PTM databases
GlyConnecti | 1172, 41 N-Linked glycans (5 sites) |
GlyGeni | Q14126, 9 sites |
iPTMneti | Q14126 |
PhosphoSitePlusi | Q14126 |
SwissPalmi | Q14126 |
Expressioni
Tissue specificityi
All of the tissues tested and carcinomas.
Gene expression databases
Bgeei | ENSG00000046604, Expressed in mucosa of sigmoid colon and 192 other tissues |
ExpressionAtlasi | Q14126, baseline and differential |
Genevisiblei | Q14126, HS |
Organism-specific databases
HPAi | ENSG00000046604, Tissue enhanced (intestine) |
Interactioni
GO - Molecular functioni
- cell adhesion molecule binding Source: BHF-UCL
- cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication Source: BHF-UCL
Protein-protein interaction databases
BioGRIDi | 108163, 92 interactors |
DIPi | DIP-46250N |
IntActi | Q14126, 52 interactors |
MINTi | Q14126 |
STRINGi | 9606.ENSP00000261590 |
Miscellaneous databases
RNActi | Q14126, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SASBDBi | Q14126 |
SMRi | Q14126 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q14126 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 50 – 160 | Cadherin 1PROSITE-ProRule annotationAdd BLAST | 111 | |
Domaini | 161 – 273 | Cadherin 2PROSITE-ProRule annotationAdd BLAST | 113 | |
Domaini | 274 – 388 | Cadherin 3PROSITE-ProRule annotationAdd BLAST | 115 | |
Domaini | 389 – 503 | Cadherin 4PROSITE-ProRule annotationAdd BLAST | 115 | |
Repeati | 881 – 912 | Desmoglein repeat 1Add BLAST | 32 | |
Repeati | 913 – 942 | Desmoglein repeat 2Add BLAST | 30 | |
Repeati | 943 – 968 | Desmoglein repeat 3Add BLAST | 26 | |
Repeati | 969 – 992 | Desmoglein repeat 4Add BLAST | 24 | |
Repeati | 993 – 1021 | Desmoglein repeat 5Add BLAST | 29 | |
Repeati | 1022 – 1051 | Desmoglein repeat 6Add BLAST | 30 |
Domaini
Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.By similarity
Keywords - Domaini
Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3594, Eukaryota |
GeneTreei | ENSGT00950000182765 |
HOGENOMi | CLU_005284_0_1_1 |
InParanoidi | Q14126 |
OMAi | DQHYANE |
OrthoDBi | 250139at2759 |
PhylomeDBi | Q14126 |
TreeFami | TF331809 |
Family and domain databases
Gene3Di | 4.10.900.10, 1 hit |
InterProi | View protein in InterPro IPR002126, Cadherin-like_dom IPR015919, Cadherin-like_sf IPR020894, Cadherin_CS IPR027397, Catenin-bd_sf IPR009123, Desmoglein IPR009122, Desmosomal_cadherin |
Pfami | View protein in Pfam PF00028, Cadherin, 3 hits |
PRINTSi | PR00205, CADHERIN PR01818, DESMOCADHERN PR01819, DESMOGLEIN |
SMARTi | View protein in SMART SM00112, CA, 4 hits |
SUPFAMi | SSF49313, SSF49313, 5 hits |
PROSITEi | View protein in PROSITE PS00232, CADHERIN_1, 3 hits PS50268, CADHERIN_2, 4 hits |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q14126-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MARSPGRAYA LLLLLICFNV GSGLHLQVLS TRNENKLLPK HPHLVRQKRA
60 70 80 90 100
WITAPVALRE GEDLSKKNPI AKIHSDLAEE RGLKITYKYT GKGITEPPFG
110 120 130 140 150
IFVFNKDTGE LNVTSILDRE ETPFFLLTGY ALDARGNNVE KPLELRIKVL
160 170 180 190 200
DINDNEPVFT QDVFVGSVEE LSAAHTLVMK INATDADEPN TLNSKISYRI
210 220 230 240 250
VSLEPAYPPV FYLNKDTGEI YTTSVTLDRE EHSSYTLTVE ARDGNGEVTD
260 270 280 290 300
KPVKQAQVQI RILDVNDNIP VVENKVLEGM VEENQVNVEV TRIKVFDADE
310 320 330 340 350
IGSDNWLANF TFASGNEGGY FHIETDAQTN EGIVTLIKEV DYEEMKNLDF
360 370 380 390 400
SVIVANKAAF HKSIRSKYKP TPIPIKVKVK NVKEGIHFKS SVISIYVSES
410 420 430 440 450
MDRSSKGQII GNFQAFDEDT GLPAHARYVK LEDRDNWISV DSVTSEIKLA
460 470 480 490 500
KLPDFESRYV QNGTYTVKIV AISEDYPRKT ITGTVLINVE DINDNCPTLI
510 520 530 540 550
EPVQTICHDA EYVNVTAEDL DGHPNSGPFS FSVIDKPPGM AEKWKIARQE
560 570 580 590 600
STSVLLQQSE KKLGRSEIQF LISDNQGFSC PEKQVLTLTV CECLHGSGCR
610 620 630 640 650
EAQHDSYVGL GPAAIALMIL AFLLLLLVPL LLLMCHCGKG AKGFTPIPGT
660 670 680 690 700
IEMLHPWNNE GAPPEDKVVP SFLPVDQGGS LVGRNGVGGM AKEATMKGSS
710 720 730 740 750
SASIVKGQHE MSEMDGRWEE HRSLLSGRAT QFTGATGAIM TTETTKTARA
760 770 780 790 800
TGASRDMAGA QAAAVALNEE FLRNYFTDKA ASYTEEDENH TAKDCLLVYS
810 820 830 840 850
QEETESLNAS IGCCSFIEGE LDDRFLDDLG LKFKTLAEVC LGQKIDINKE
860 870 880 890 900
IEQRQKPATE TSMNTASHSL CEQTMVNSEN TYSSGSSFPV PKSLQEANAE
910 920 930 940 950
KVTQEIVTER SVSSRQAQKV ATPLPDPMAS RNVIATETSY VTGSTMPPTT
960 970 980 990 1000
VILGPSQPQS LIVTERVYAP ASTLVDQPYA NEGTVVVTER VIQPHGGGSN
1010 1020 1030 1040 1050
PLEGTQHLQD VPYVMVRERE SFLAPSSGVQ PTLAMPNIAV GQNVTVTERV
1060 1070 1080 1090 1100
LAPASTLQSS YQIPTENSMT ARNTTVSGAG VPGPLPDFGL EESGHSNSTI
1110
TTSSTRVTKH STVQHSYS
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketJ3KSI6 | J3KSI6_HUMAN | Desmoglein-2 | DSG2 | 232 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 4 – 10 | SPGRAYA → TRDRVR in CAA81226 (PubMed:8143788).Curated | 7 | |
Sequence conflicti | 593 | C → V in CAA81226 (PubMed:8143788).Curated | 1 | |
Sequence conflicti | 643 | G → A in CAA81226 (PubMed:8143788).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_029365 | 46 | R → Q in ARVD10. 2 PublicationsCorresponds to variant dbSNP:rs121913008EnsemblClinVar. | 1 | |
Natural variantiVAR_029366 | 49 | R → H in ARVD10. 4 PublicationsCorresponds to variant dbSNP:rs121913006EnsemblClinVar. | 1 | |
Natural variantiVAR_062387 | 56 | V → M Associated with CMD1BB and ARVD10 although it may not be sufficient by itself to result in cardiomyopathy. 2 PublicationsCorresponds to variant dbSNP:rs121913013EnsemblClinVar. | 1 | |
Natural variantiVAR_048508 | 89 | Y → C. Corresponds to variant dbSNP:rs2230232EnsemblClinVar. | 1 | |
Natural variantiVAR_062388 | 158 | V → G1 PublicationCorresponds to variant dbSNP:rs191143292EnsemblClinVar. | 1 | |
Natural variantiVAR_048509 | 293 | I → V2 PublicationsCorresponds to variant dbSNP:rs2230234EnsemblClinVar. | 1 | |
Natural variantiVAR_065686 | 335 | T → A in ARVD10. 1 PublicationCorresponds to variant dbSNP:rs191564916EnsemblClinVar. | 1 | |
Natural variantiVAR_029367 | 507 | C → Y in ARVD10. 2 PublicationsCorresponds to variant dbSNP:rs121913009EnsemblClinVar. | 1 | |
Natural variantiVAR_048510 | 515 | V → I. Corresponds to variant dbSNP:rs2230235EnsemblClinVar. | 1 | |
Natural variantiVAR_062389 | 713 | E → K2 PublicationsCorresponds to variant dbSNP:rs79241126EnsemblClinVar. | 1 | |
Natural variantiVAR_048511 | 773 | R → K2 PublicationsCorresponds to variant dbSNP:rs2278792EnsemblClinVar. | 1 | |
Natural variantiVAR_029368 | 812 | G → C in ARVD10. 2 PublicationsCorresponds to variant dbSNP:rs121913010EnsemblClinVar. | 1 | |
Natural variantiVAR_048512 | 863 | M → L. Corresponds to variant dbSNP:rs16962093EnsemblClinVar. | 1 | |
Natural variantiVAR_048513 | 903 | T → I. Corresponds to variant dbSNP:rs34065672EnsemblClinVar. | 1 | |
Natural variantiVAR_062390 | 920 | V → G2 PublicationsCorresponds to variant dbSNP:rs142841727EnsemblClinVar. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z26317 mRNA Translation: CAA81226.1 BC099655 mRNA Translation: AAH99655.1 BC099656 mRNA Translation: AAH99656.1 BC099657 mRNA Translation: AAH99657.1 |
CCDSi | CCDS42423.1 |
PIRi | S38673 |
RefSeqi | NP_001934.2, NM_001943.4 |
Genome annotation databases
Ensembli | ENST00000261590; ENSP00000261590; ENSG00000046604 |
GeneIDi | 1829 |
KEGGi | hsa:1829 |
UCSCi | uc002kwu.5, human |
Similar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z26317 mRNA Translation: CAA81226.1 BC099655 mRNA Translation: AAH99655.1 BC099656 mRNA Translation: AAH99656.1 BC099657 mRNA Translation: AAH99657.1 |
CCDSi | CCDS42423.1 |
PIRi | S38673 |
RefSeqi | NP_001934.2, NM_001943.4 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2YQG | NMR | - | A | 47-162 | [»] | |
5ERD | X-ray | 2.90 | A/B | 50-602 | [»] | |
5J5J | X-ray | 3.29 | A | 152-601 | [»] | |
6QNT | electron microscopy | 3.50 | D | 157-380 | [»] | |
6QNU | electron microscopy | 3.80 | D/E | 157-380 | [»] | |
6SIT | X-ray | 4.50 | D | 149-386 | [»] | |
7AGF | electron microscopy | 3.10 | D/E/F | 149-386 | [»] | |
7AGG | electron microscopy | 3.30 | D/F | 149-386 | [»] | |
SASBDBi | Q14126 | |||||
SMRi | Q14126 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 108163, 92 interactors |
DIPi | DIP-46250N |
IntActi | Q14126, 52 interactors |
MINTi | Q14126 |
STRINGi | 9606.ENSP00000261590 |
PTM databases
GlyConnecti | 1172, 41 N-Linked glycans (5 sites) |
GlyGeni | Q14126, 9 sites |
iPTMneti | Q14126 |
PhosphoSitePlusi | Q14126 |
SwissPalmi | Q14126 |
Genetic variation databases
BioMutai | DSG2 |
DMDMi | 148876773 |
Proteomic databases
CPTACi | CPTAC-1307 |
EPDi | Q14126 |
jPOSTi | Q14126 |
MassIVEi | Q14126 |
MaxQBi | Q14126 |
PaxDbi | Q14126 |
PeptideAtlasi | Q14126 |
PRIDEi | Q14126 |
ProteomicsDBi | 59829 |
Protocols and materials databases
Antibodypediai | 1349, 690 antibodies |
Genome annotation databases
Ensembli | ENST00000261590; ENSP00000261590; ENSG00000046604 |
GeneIDi | 1829 |
KEGGi | hsa:1829 |
UCSCi | uc002kwu.5, human |
Organism-specific databases
CTDi | 1829 |
DisGeNETi | 1829 |
GeneCardsi | DSG2 |
GeneReviewsi | DSG2 |
HGNCi | HGNC:3049, DSG2 |
HPAi | ENSG00000046604, Tissue enhanced (intestine) |
MalaCardsi | DSG2 |
MIMi | 125671, gene 610193, phenotype 612877, phenotype |
neXtProti | NX_Q14126 |
OpenTargetsi | ENSG00000046604 |
Orphaneti | 293899, Familial isolated arrhythmogenic ventricular dysplasia, biventricular form 293888, Familial isolated arrhythmogenic ventricular dysplasia, left dominant form 293910, Familial isolated arrhythmogenic ventricular dysplasia, right dominant form 154, Familial isolated dilated cardiomyopathy |
PharmGKBi | PA27502 |
VEuPathDBi | HostDB:ENSG00000046604.12 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3594, Eukaryota |
GeneTreei | ENSGT00950000182765 |
HOGENOMi | CLU_005284_0_1_1 |
InParanoidi | Q14126 |
OMAi | DQHYANE |
OrthoDBi | 250139at2759 |
PhylomeDBi | Q14126 |
TreeFami | TF331809 |
Enzyme and pathway databases
PathwayCommonsi | Q14126 |
Reactomei | R-HSA-351906, Apoptotic cleavage of cell adhesion proteins R-HSA-6805567, Keratinization R-HSA-6809371, Formation of the cornified envelope |
Miscellaneous databases
BioGRID-ORCSi | 1829, 13 hits in 880 CRISPR screens |
ChiTaRSi | DSG2, human |
EvolutionaryTracei | Q14126 |
GeneWikii | Desmoglein_2 |
GenomeRNAii | 1829 |
Pharosi | Q14126, Tbio |
PROi | PR:Q14126 |
RNActi | Q14126, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000046604, Expressed in mucosa of sigmoid colon and 192 other tissues |
ExpressionAtlasi | Q14126, baseline and differential |
Genevisiblei | Q14126, HS |
Family and domain databases
Gene3Di | 4.10.900.10, 1 hit |
InterProi | View protein in InterPro IPR002126, Cadherin-like_dom IPR015919, Cadherin-like_sf IPR020894, Cadherin_CS IPR027397, Catenin-bd_sf IPR009123, Desmoglein IPR009122, Desmosomal_cadherin |
Pfami | View protein in Pfam PF00028, Cadherin, 3 hits |
PRINTSi | PR00205, CADHERIN PR01818, DESMOCADHERN PR01819, DESMOGLEIN |
SMARTi | View protein in SMART SM00112, CA, 4 hits |
SUPFAMi | SSF49313, SSF49313, 5 hits |
PROSITEi | View protein in PROSITE PS00232, CADHERIN_1, 3 hits PS50268, CADHERIN_2, 4 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | DSG2_HUMAN | |
Accessioni | Q14126Primary (citable) accession number: Q14126 Secondary accession number(s): Q4KKU6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | May 29, 2007 | |
Last modified: | February 10, 2021 | |
This is version 197 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 18
Human chromosome 18: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references