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Protein

Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C

Gene

PDE1C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a high affinity for both cAMP and cGMP.

Catalytic activityi

Nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate.

Cofactori

a divalent metal cationBy similarityNote: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.By similarity

Activity regulationi

Type I PDE are activated by the binding of calmodulin in the presence of Ca2+.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei228Proton donorBy similarity1
Metal bindingi232Divalent metal cation 1; via tele nitrogenBy similarity1
Metal bindingi268Divalent metal cation 1; via tele nitrogenBy similarity1
Metal bindingi269Divalent metal cation 1By similarity1
Metal bindingi269Divalent metal cation 2By similarity1
Metal bindingi376Divalent metal cation 1By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCalmodulin-binding, Hydrolase
LigandcAMP, cGMP, Metal-binding

Enzyme and pathway databases

BRENDAi3.1.4.17 2681
ReactomeiR-HSA-111957 Cam-PDE 1 activation

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (EC:3.1.4.17)
Short name:
Cam-PDE 1C
Alternative name(s):
hCam-3
Gene namesi
Name:PDE1C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000154678.16
HGNCiHGNC:8776 PDE1C
MIMi602987 gene
neXtProtiNX_Q14123

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi5137
OpenTargetsiENSG00000154678
PharmGKBiPA33124

Chemistry databases

ChEMBLiCHEMBL4619
DrugBankiDB00201 Caffeine
GuidetoPHARMACOLOGYi1296

Polymorphism and mutation databases

BioMutaiPDE1C
DMDMi2499445

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001987921 – 709Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1CAdd BLAST709

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ14123
PaxDbiQ14123
PeptideAtlasiQ14123
PRIDEiQ14123
ProteomicsDBi59827
59828 [Q14123-2]

PTM databases

iPTMnetiQ14123
PhosphoSitePlusiQ14123

Expressioni

Tissue specificityi

Expressed in several tissues, including brain and heart.

Gene expression databases

BgeeiENSG00000154678 Expressed in 160 organ(s), highest expression level in corpus callosum
CleanExiHS_PDE1C
ExpressionAtlasiQ14123 baseline and differential
GenevisibleiQ14123 HS

Organism-specific databases

HPAiHPA021751
HPA052375

Interactioni

Subunit structurei

Homodimer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi111163, 4 interactors
STRINGi9606.ENSP00000379496

Chemistry databases

BindingDBiQ14123

Structurei

3D structure databases

ProteinModelPortaliQ14123
SMRiQ14123
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini151 – 528PDEasePROSITE-ProRule annotationAdd BLAST378

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3688 Eukaryota
ENOG410XQDD LUCA
GeneTreeiENSGT00760000118889
HOGENOMiHOG000231888
HOVERGENiHBG056120
KOiK13755
PhylomeDBiQ14123
TreeFamiTF314638

Family and domain databases

CDDicd00077 HDc, 1 hit
Gene3Di1.10.1300.10, 1 hit
InterProiView protein in InterPro
IPR003607 HD/PDEase_dom
IPR023088 PDEase
IPR002073 PDEase_catalytic_dom
IPR036971 PDEase_catalytic_dom_sf
IPR023174 PDEase_CS
IPR013706 PDEase_N
PfamiView protein in Pfam
PF00233 PDEase_I, 1 hit
PF08499 PDEase_I_N, 1 hit
PRINTSiPR00387 PDIESTERASE1
SMARTiView protein in SMART
SM00471 HDc, 1 hit
PROSITEiView protein in PROSITE
PS00126 PDEASE_I_1, 1 hit
PS51845 PDEASE_I_2, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform PDE1C2 (identifier: Q14123-1) [UniParc]FASTAAdd to basket
Also known as: HCam-3A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MESPTKEIEE FESNSLKYLQ PEQIEKIWLR LRGLRKYKKT SQRLRSLVKQ
60 70 80 90 100
LERGEASVVD LKKNLEYAAT VLESVYIDET RRLLDTEDEL SDIQSDAVPS
110 120 130 140 150
EVRDWLASTF TRQMGMMLRR SDEKPRFKSI VHAVQAGIFV ERMYRRTSNM
160 170 180 190 200
VGLSYPPAVI EALKDVDKWS FDVFSLNEAS GDHALKFIFY ELLTRYDLIS
210 220 230 240 250
RFKIPISALV SFVEALEVGY SKHKNPYHNL MHAADVTQTV HYLLYKTGVA
260 270 280 290 300
NWLTELEIFA IIFSAAIHDY EHTGTTNNFH IQTRSDPAIL YNDRSVLENH
310 320 330 340 350
HLSAAYRLLQ DDEEMNILIN LSKDDWREFR TLVIEMVMAT DMSCHFQQIK
360 370 380 390 400
AMKTALQQPE AIEKPKALSL MLHTADISHP AKAWDLHHRW TMSLLEEFFR
410 420 430 440 450
QGDREAELGL PFSPLCDRKS TMVAQSQVGF IDFIVEPTFT VLTDMTEKIV
460 470 480 490 500
SPLIDETSQT GGTGQRRSSL NSISSSDAKR SGVKTSGSEG SAPINNSVIS
510 520 530 540 550
VDYKSFKATW TEVVHINRER WRAKVPKEEK AKKEAEEKAR LAAEEQQKEM
560 570 580 590 600
EAKSQAEEGA SGKAEKKTSG ETKNQVNGTR ANKSDNPRGK NSKAEKSSGE
610 620 630 640 650
QQQNGDFKDG KNKTDKKDHS NIGNDSKKTD GTKQRSHGSP APSTSSTCRL
660 670 680 690 700
TLPVIKPPLR HFKRPAYASS SYAPSVSKKT DEHPARYKML DQRIKMKKIQ

NISHNWNRK
Length:709
Mass (Da):80,760
Last modified:November 1, 1997 - v1
Checksum:i77133D4DDBE5F7C0
GO
Isoform PDE1C1 (identifier: Q14123-2) [UniParc]FASTAAdd to basket
Also known as: HCam-3B

The sequence of this isoform differs from the canonical sequence as follows:
     631-634: GTKQ → DSQE
     635-709: Missing.

Show »
Length:634
Mass (Da):72,208
Checksum:i73F9A72EDCEAF6F7
GO
Isoform 3 (identifier: Q14123-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-38: MESPTKEIEE...LRLRGLRKYK → MTDAGNRKEG...PQLDSSEVLV

Note: No experimental confirmation available.Curated
Show »
Length:769
Mass (Da):86,896
Checksum:i47B4A412522129DA
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MS69A0A0A0MS69_HUMAN
Phosphodiesterase
PDE1C
769Annotation score:
F8W905F8W905_HUMAN
Calcium/calmodulin-dependent 3',5'-...
PDE1C
46Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti42Q → F in BAC03734 (PubMed:14702039).Curated1
Sequence conflicti126R → L in BAC03734 (PubMed:14702039).Curated1
Isoform 3 (identifier: Q14123-3)
Sequence conflicti4A → V in BAC03734 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0444681 – 38MESPT…LRKYK → MTDAGNRKEGFKKCRSATFS IDGYSFTIVANEAGDKNARP LARFSRSKSQNCLWNSLIDG LTGNVKEKPRPTIVHDPRPP EEILADELPQLDSSEVLV in isoform 3. 1 PublicationAdd BLAST38
Alternative sequenceiVSP_004552631 – 634GTKQ → DSQE in isoform PDE1C1. 1 Publication4
Alternative sequenceiVSP_004553635 – 709Missing in isoform PDE1C1. 1 PublicationAdd BLAST75

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U40371 mRNA Translation: AAC50437.1
U40372 mRNA Translation: AAA96961.1
AK056170 mRNA Translation: BAG51638.1
AK091734 mRNA Translation: BAC03734.1
AC004931 Genomic DNA No translation available.
AC005589 Genomic DNA No translation available.
AC006377 Genomic DNA No translation available.
AC007033 Genomic DNA No translation available.
AC007093 Genomic DNA No translation available.
AC018637 Genomic DNA No translation available.
CCDSiCCDS5437.1 [Q14123-2]
CCDS55099.1 [Q14123-1]
CCDS55100.1 [Q14123-3]
RefSeqiNP_001177985.1, NM_001191056.3 [Q14123-2]
NP_001177986.1, NM_001191057.3 [Q14123-1]
NP_001177987.2, NM_001191058.3
NP_001177988.1, NM_001191059.3 [Q14123-1]
NP_001308984.1, NM_001322055.1 [Q14123-1]
NP_001308985.1, NM_001322056.1 [Q14123-2]
NP_001308986.1, NM_001322057.1 [Q14123-2]
NP_001308987.1, NM_001322058.1
NP_001308988.1, NM_001322059.1
NP_005011.1, NM_005020.4 [Q14123-2]
XP_016867756.1, XM_017012267.1 [Q14123-1]
UniGeneiHs.143821
Hs.290550
Hs.595197
Hs.728862

Genome annotation databases

EnsembliENST00000321453; ENSP00000318105; ENSG00000154678 [Q14123-1]
ENST00000396182; ENSP00000379485; ENSG00000154678 [Q14123-2]
ENST00000396184; ENSP00000379487; ENSG00000154678 [Q14123-2]
ENST00000396191; ENSP00000379494; ENSG00000154678 [Q14123-1]
GeneIDi5137
KEGGihsa:5137
UCSCiuc003tcm.3 human [Q14123-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U40371 mRNA Translation: AAC50437.1
U40372 mRNA Translation: AAA96961.1
AK056170 mRNA Translation: BAG51638.1
AK091734 mRNA Translation: BAC03734.1
AC004931 Genomic DNA No translation available.
AC005589 Genomic DNA No translation available.
AC006377 Genomic DNA No translation available.
AC007033 Genomic DNA No translation available.
AC007093 Genomic DNA No translation available.
AC018637 Genomic DNA No translation available.
CCDSiCCDS5437.1 [Q14123-2]
CCDS55099.1 [Q14123-1]
CCDS55100.1 [Q14123-3]
RefSeqiNP_001177985.1, NM_001191056.3 [Q14123-2]
NP_001177986.1, NM_001191057.3 [Q14123-1]
NP_001177987.2, NM_001191058.3
NP_001177988.1, NM_001191059.3 [Q14123-1]
NP_001308984.1, NM_001322055.1 [Q14123-1]
NP_001308985.1, NM_001322056.1 [Q14123-2]
NP_001308986.1, NM_001322057.1 [Q14123-2]
NP_001308987.1, NM_001322058.1
NP_001308988.1, NM_001322059.1
NP_005011.1, NM_005020.4 [Q14123-2]
XP_016867756.1, XM_017012267.1 [Q14123-1]
UniGeneiHs.143821
Hs.290550
Hs.595197
Hs.728862

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1LXSmodel-A163-460[»]
ProteinModelPortaliQ14123
SMRiQ14123
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111163, 4 interactors
STRINGi9606.ENSP00000379496

Chemistry databases

BindingDBiQ14123
ChEMBLiCHEMBL4619
DrugBankiDB00201 Caffeine
GuidetoPHARMACOLOGYi1296

PTM databases

iPTMnetiQ14123
PhosphoSitePlusiQ14123

Polymorphism and mutation databases

BioMutaiPDE1C
DMDMi2499445

Proteomic databases

MaxQBiQ14123
PaxDbiQ14123
PeptideAtlasiQ14123
PRIDEiQ14123
ProteomicsDBi59827
59828 [Q14123-2]

Protocols and materials databases

DNASUi5137
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000321453; ENSP00000318105; ENSG00000154678 [Q14123-1]
ENST00000396182; ENSP00000379485; ENSG00000154678 [Q14123-2]
ENST00000396184; ENSP00000379487; ENSG00000154678 [Q14123-2]
ENST00000396191; ENSP00000379494; ENSG00000154678 [Q14123-1]
GeneIDi5137
KEGGihsa:5137
UCSCiuc003tcm.3 human [Q14123-1]

Organism-specific databases

CTDi5137
DisGeNETi5137
EuPathDBiHostDB:ENSG00000154678.16
GeneCardsiPDE1C
HGNCiHGNC:8776 PDE1C
HPAiHPA021751
HPA052375
MIMi602987 gene
neXtProtiNX_Q14123
OpenTargetsiENSG00000154678
PharmGKBiPA33124
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3688 Eukaryota
ENOG410XQDD LUCA
GeneTreeiENSGT00760000118889
HOGENOMiHOG000231888
HOVERGENiHBG056120
KOiK13755
PhylomeDBiQ14123
TreeFamiTF314638

Enzyme and pathway databases

BRENDAi3.1.4.17 2681
ReactomeiR-HSA-111957 Cam-PDE 1 activation

Miscellaneous databases

ChiTaRSiPDE1C human
GeneWikiiPDE1C
GenomeRNAii5137
PROiPR:Q14123
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000154678 Expressed in 160 organ(s), highest expression level in corpus callosum
CleanExiHS_PDE1C
ExpressionAtlasiQ14123 baseline and differential
GenevisibleiQ14123 HS

Family and domain databases

CDDicd00077 HDc, 1 hit
Gene3Di1.10.1300.10, 1 hit
InterProiView protein in InterPro
IPR003607 HD/PDEase_dom
IPR023088 PDEase
IPR002073 PDEase_catalytic_dom
IPR036971 PDEase_catalytic_dom_sf
IPR023174 PDEase_CS
IPR013706 PDEase_N
PfamiView protein in Pfam
PF00233 PDEase_I, 1 hit
PF08499 PDEase_I_N, 1 hit
PRINTSiPR00387 PDIESTERASE1
SMARTiView protein in SMART
SM00471 HDc, 1 hit
PROSITEiView protein in PROSITE
PS00126 PDEASE_I_1, 1 hit
PS51845 PDEASE_I_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPDE1C_HUMAN
AccessioniPrimary (citable) accession number: Q14123
Secondary accession number(s): B3KPC6
, E9PE92, Q14124, Q8NB10
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: September 12, 2018
This is version 153 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
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