UniProtKB - Q14119 (VEZF1_HUMAN)
Protein
Vascular endothelial zinc finger 1
Gene
VEZF1
Organism
Homo sapiens (Human)
Status
Functioni
Possible transcription factor. Specifically binds to the CT/GC-rich region of the interleukin-3 promoter and mediates tax transactivation of IL-3.1 Publication
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 74 – 96 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 174 – 196 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 202 – 224 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 232 – 255 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 261 – 283 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 287 – 308 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 22 |
GO - Molecular functioni
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: NTNU_SB
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: NTNU_SB
GO - Biological processi
- angiogenesis Source: Ensembl
- cellular defense response Source: ProtInc
- endothelial cell development Source: Ensembl
- positive regulation of endothelial cell differentiation Source: BHF-UCL
- positive regulation of transcription by RNA polymerase II Source: NTNU_SB
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | Activator, DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q14119 |
Names & Taxonomyi
Protein namesi | Recommended name: Vascular endothelial zinc finger 1Alternative name(s): Putative transcription factor DB1 Zinc finger protein 161 |
Gene namesi | Name:VEZF1 Synonyms:DB1, ZNF161 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000136451.8 |
HGNCi | HGNC:12949, VEZF1 |
MIMi | 606747, gene |
neXtProti | NX_Q14119 |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
Nucleus
- nucleoplasm Source: HPA
- nucleus Source: GO_Central
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 7716 |
OpenTargetsi | ENSG00000136451 |
PharmGKBi | PA162408823 |
Miscellaneous databases
Pharosi | Q14119, Tbio |
Polymorphism and mutation databases
BioMutai | VEZF1 |
DMDMi | 317373301 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047435 | 1 – 521 | Vascular endothelial zinc finger 1Add BLAST | 521 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 362 | N6-acetyllysineCombined sources | 1 |
Keywords - PTMi
AcetylationProteomic databases
EPDi | Q14119 |
jPOSTi | Q14119 |
MassIVEi | Q14119 |
MaxQBi | Q14119 |
PaxDbi | Q14119 |
PeptideAtlasi | Q14119 |
PRIDEi | Q14119 |
ProteomicsDBi | 59826 |
PTM databases
GlyGeni | Q14119, 5 sites, 1 O-linked glycan (5 sites) |
iPTMneti | Q14119 |
PhosphoSitePlusi | Q14119 |
Expressioni
Tissue specificityi
Ubiquitously expressed. Highest levels in skeletal muscle and kidney.1 Publication
Gene expression databases
Bgeei | ENSG00000136451, Expressed in epithelium of mammary gland and 245 other tissues |
ExpressionAtlasi | Q14119, baseline and differential |
Genevisiblei | Q14119, HS |
Organism-specific databases
HPAi | ENSG00000136451, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with ARHGAP22.
By similarityBinary interactionsi
Q14119
Protein-protein interaction databases
BioGRIDi | 113509, 73 interactors |
IntActi | Q14119, 63 interactors |
STRINGi | 9606.ENSP00000462337 |
Miscellaneous databases
RNActi | Q14119, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 394 – 400 | 1 | 7 | |
Repeati | 445 – 451 | 2 | 7 | |
Repeati | 457 – 463 | 3 | 7 | |
Repeati | 479 – 485 | 4 | 7 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 394 – 485 | 4 X 7 AA repeats of P-[LV]-T-[IL]-T-[ST]-PAdd BLAST | 92 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 340 – 354 | Poly-GlnAdd BLAST | 15 |
Sequence similaritiesi
Belongs to the krueppel C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 74 – 96 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 174 – 196 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 202 – 224 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 232 – 255 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 261 – 283 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 287 – 308 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 22 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000155932 |
InParanoidi | Q14119 |
OMAi | VDSMPFL |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q14119 |
TreeFami | TF331686 |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 3 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 6 hits |
SUPFAMi | SSF57667, SSF57667, 3 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 5 hits PS50157, ZINC_FINGER_C2H2_2, 5 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
Q14119-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEANWTAFLF QAHEASHHQQ QAAQNSLLPL LSSAVEPPDQ KPLLPIPITQ
60 70 80 90 100
KPQGAPETLK DAIGIKKEKP KTSFVCTYCS KAFRDSYHLR RHESCHTGIK
110 120 130 140 150
LVSRPKKTPT TVVPLISTIA GDSSRTSLVS TIAGILSTVT TSSSGTNPSS
160 170 180 190 200
SASTTAMPVT QSVKKPSKPV KKNHACEMCG KAFRDVYHLN RHKLSHSDEK
210 220 230 240 250
PFECPICNQR FKRKDRMTYH VRSHEGGITK PYTCSVCGKG FSRPDHLSCH
260 270 280 290 300
VKHVHSTERP FKCQTCTAAF ATKDRLRTHM VRHEGKVSCN ICGKLLSAAY
310 320 330 340 350
ITSHLKTHGQ SQSINCNTCK QGISKTCMSE ETSNQKQQQQ QQQQQQQQQQ
360 370 380 390 400
QQQQHVTSWP GKQVETLRLW EEAVKARKKE AANLCQTSTA ATTPVTLTTP
410 420 430 440 450
FSITSSVSSG TMSNPVTVAA AMSMRSPVNV SSAVNITSPM NIGHPVTITS
460 470 480 490 500
PLSMTSPLTL TTPVNLPTPV TAPVNIAHPV TITSPMNLPT PMTLAAPLNI
510 520
AMRPVESMPF LPQALPTSPP W
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketJ3QSH4 | J3QSH4_HUMAN | Vascular endothelial zinc finger 1 | VEZF1 | 512 | Annotation score: | ||
J9JIC7 | J9JIC7_HUMAN | Vascular endothelial zinc finger 1 | VEZF1 | 340 | Annotation score: | ||
J3QLN5 | J3QLN5_HUMAN | Vascular endothelial zinc finger 1 | VEZF1 | 16 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 350 – 354 | Missing in BAA05663 (PubMed:8035792).Curated | 5 | |
Sequence conflicti | 410 | G → E in BAA05663 (PubMed:8035792).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D28118 mRNA Translation: BAA05663.1 AC015813 Genomic DNA No translation available. |
CCDSi | CCDS32687.1 |
PIRi | A53772 |
RefSeqi | NP_009077.2, NM_007146.2 |
Genome annotation databases
Ensembli | ENST00000581208; ENSP00000462337; ENSG00000136451 |
GeneIDi | 7716 |
KEGGi | hsa:7716 |
UCSCi | uc002ivf.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D28118 mRNA Translation: BAA05663.1 AC015813 Genomic DNA No translation available. |
CCDSi | CCDS32687.1 |
PIRi | A53772 |
RefSeqi | NP_009077.2, NM_007146.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 113509, 73 interactors |
IntActi | Q14119, 63 interactors |
STRINGi | 9606.ENSP00000462337 |
PTM databases
GlyGeni | Q14119, 5 sites, 1 O-linked glycan (5 sites) |
iPTMneti | Q14119 |
PhosphoSitePlusi | Q14119 |
Polymorphism and mutation databases
BioMutai | VEZF1 |
DMDMi | 317373301 |
Proteomic databases
EPDi | Q14119 |
jPOSTi | Q14119 |
MassIVEi | Q14119 |
MaxQBi | Q14119 |
PaxDbi | Q14119 |
PeptideAtlasi | Q14119 |
PRIDEi | Q14119 |
ProteomicsDBi | 59826 |
Protocols and materials databases
Antibodypediai | 18343, 102 antibodies |
DNASUi | 7716 |
Genome annotation databases
Ensembli | ENST00000581208; ENSP00000462337; ENSG00000136451 |
GeneIDi | 7716 |
KEGGi | hsa:7716 |
UCSCi | uc002ivf.2, human |
Organism-specific databases
CTDi | 7716 |
DisGeNETi | 7716 |
EuPathDBi | HostDB:ENSG00000136451.8 |
GeneCardsi | VEZF1 |
HGNCi | HGNC:12949, VEZF1 |
HPAi | ENSG00000136451, Low tissue specificity |
MIMi | 606747, gene |
neXtProti | NX_Q14119 |
OpenTargetsi | ENSG00000136451 |
PharmGKBi | PA162408823 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000155932 |
InParanoidi | Q14119 |
OMAi | VDSMPFL |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q14119 |
TreeFami | TF331686 |
Enzyme and pathway databases
PathwayCommonsi | Q14119 |
Miscellaneous databases
BioGRID-ORCSi | 7716, 73 hits in 866 CRISPR screens |
ChiTaRSi | VEZF1, human |
GenomeRNAii | 7716 |
Pharosi | Q14119, Tbio |
PROi | PR:Q14119 |
RNActi | Q14119, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000136451, Expressed in epithelium of mammary gland and 245 other tissues |
ExpressionAtlasi | Q14119, baseline and differential |
Genevisiblei | Q14119, HS |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 3 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 6 hits |
SUPFAMi | SSF57667, SSF57667, 3 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 5 hits PS50157, ZINC_FINGER_C2H2_2, 5 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | VEZF1_HUMAN | |
Accessioni | Q14119Primary (citable) accession number: Q14119 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1999 |
Last sequence update: | January 11, 2011 | |
Last modified: | December 2, 2020 | |
This is version 183 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM