Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - Q14119 (VEZF1_HUMAN)

Entry version 182 (07 Oct 2020)
Sequence version 2 (11 Jan 2011)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Vascular endothelial zinc finger 1

Gene

VEZF1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Possible transcription factor. Specifically binds to the CT/GC-rich region of the interleukin-3 promoter and mediates tax transactivation of IL-3.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri74 – 96C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri174 – 196C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri202 – 224C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri232 – 255C2H2-type 4PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri261 – 283C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri287 – 308C2H2-type 6PROSITE-ProRule annotationAdd BLAST22

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q14119

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Vascular endothelial zinc finger 1
Alternative name(s):
Putative transcription factor DB1
Zinc finger protein 161
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:VEZF1
Synonyms:DB1, ZNF161
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000136451.8

Human Gene Nomenclature Database

More...HGNCi		HGNC:12949, VEZF1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		606747, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q14119

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		7716

Open Targets

More...OpenTargetsi		ENSG00000136451

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA162408823

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q14119, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		VEZF1

Domain mapping of disease mutations (DMDM)

More...DMDMi		317373301

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000474351 – 521Vascular endothelial zinc finger 1Add BLAST521

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei362N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q14119

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q14119

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q14119

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q14119

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q14119

PeptideAtlas

More...PeptideAtlasi		Q14119

PRoteomics IDEntifications database

More...PRIDEi		Q14119

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		59826

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q14119, 5 sites, 1 O-linked glycan (5 sites)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q14119

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q14119

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitously expressed. Highest levels in skeletal muscle and kidney.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000136451, Expressed in epithelium of mammary gland and 245 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q14119, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q14119, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000136451, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with ARHGAP22.

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q14119
With#Exp.IntAct
AGR2 [O95994]5EBI-11980193,EBI-712648
ARHGEF9 [O43307]3EBI-11980193,EBI-3447299
BANP - isoform 2 [Q8N9N5-2]3EBI-11980193,EBI-11524452
C10orf55 [Q5SWW7]5EBI-11980193,EBI-12809220
CAPN3 - isoform IV [P20807-4]3EBI-11980193,EBI-11532021
CEACAM6 [P40199]3EBI-11980193,EBI-4314501
CEP76 [Q8TAP6]3EBI-11980193,EBI-742887
DAZAP2 [Q15038]3EBI-11980193,EBI-724310
DDIT4L [Q96D03]3EBI-11980193,EBI-742054
EHMT2 [Q96KQ7]3EBI-11980193,EBI-744366
EIF3F [O00303]3EBI-11980193,EBI-711990
FAM153B - isoform 2 [P0C7A2-2]3EBI-11980193,EBI-12940382
FAM168B - isoform 2 [A1KXE4-2]3EBI-11980193,EBI-12193763
FOSB [P53539]3EBI-11980193,EBI-2806743
FSD2 [A1L4K1]3EBI-11980193,EBI-5661036
GOLGA2 [Q08379]3EBI-11980193,EBI-618309
GOLGA6L9 [A6NEM1]3EBI-11980193,EBI-5916454
GPSM1 - isoform 3 [Q86YR5-3]3EBI-11980193,EBI-10261098
HSF2BP [O75031]3EBI-11980193,EBI-7116203
HSPB2 [Q16082]3EBI-11980193,EBI-739395
INCA1 [Q0VD86]3EBI-11980193,EBI-6509505
KCTD7 - isoform 2 [Q96MP8-2]3EBI-11980193,EBI-11954971
KIAA1218 [A4D0Q3]3EBI-11980193,EBI-14308786
KRT40 [Q6A162]3EBI-11980193,EBI-10171697
KRTAP10-8 [P60410]3EBI-11980193,EBI-10171774
KRTAP19-5 [Q3LI72]3EBI-11980193,EBI-1048945
KRTAP8-1 [Q8IUC2]3EBI-11980193,EBI-10261141
LASP1 - isoform 2 [Q14847-2]3EBI-11980193,EBI-9088686
LCN2 [P80188]3EBI-11980193,EBI-11911016
LHX3 - isoform B [Q9UBR4-2]5EBI-11980193,EBI-12039345
LMO2 - isoform 3 [P25791-3]3EBI-11980193,EBI-11959475
LZTS2 [Q9BRK4]3EBI-11980193,EBI-741037
MEIS3 - isoform 3 [Q99687-3]3EBI-11980193,EBI-18582591
MLLT10 - isoform 2 [P55197-2]3EBI-11980193,EBI-12853322
MSX2 [P35548]3EBI-11980193,EBI-6447480
NCKIPSD - isoform 3 [Q9NZQ3-3]3EBI-11980193,EBI-10963850
NFYA - isoform Short [P23511-2]3EBI-11980193,EBI-11061759
NRF1 - isoform 4 [Q16656-4]3EBI-11980193,EBI-11742836
PFDN5 [Q99471]3EBI-11980193,EBI-357275
PICK1 [Q9NRD5]3EBI-11980193,EBI-79165
PLAGL2 [Q9UPG8]3EBI-11980193,EBI-2876622
POGZ [Q7Z3K3]3EBI-11980193,EBI-1389308
POU6F2 [P78424]3EBI-11980193,EBI-12029004
PRKAR1B [P31321]3EBI-11980193,EBI-2805516
PRR20D [P86480]3EBI-11980193,EBI-12754095
RBPMS - isoform C [Q93062-3]3EBI-11980193,EBI-740343
RUBCN [Q92622]3EBI-11980193,EBI-2952709
SF3A2 [Q15428]3EBI-11980193,EBI-2462271
SOX13 [Q9UN79]3EBI-11980193,EBI-3928516
SP4 [Q02446]3EBI-11980193,EBI-10198587
SPAG16 - isoform 4 [Q8N0X2-4]3EBI-11980193,EBI-11946259
TLE5 - isoform 2 [Q08117-2]3EBI-11980193,EBI-11741437
TRAF1 [Q13077]3EBI-11980193,EBI-359224
TRAF2 [Q12933]3EBI-11980193,EBI-355744
TRIM27 [P14373]3EBI-11980193,EBI-719493
TSC1 [Q86WV8]3EBI-11980193,EBI-12806590
UBE2I [Q7KZS0]3EBI-11980193,EBI-10180829
VBP1 [P61758]3EBI-11980193,EBI-357430
VPS52 [Q8N1B4]3EBI-11980193,EBI-2799833
WWOX - isoform 5 [Q9NZC7-5]3EBI-11980193,EBI-12040603
ZMYND12 [Q9H0C1]3EBI-11980193,EBI-12030590
ZRANB1 [Q9UGI0]3EBI-11980193,EBI-527853

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		113509, 73 interactors

Protein interaction database and analysis system

More...IntActi		Q14119, 63 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000462337

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q14119, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati394 – 40017
Repeati445 – 45127
Repeati457 – 46337
Repeati479 – 48547

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni394 – 4854 X 7 AA repeats of P-[LV]-T-[IL]-T-[ST]-PAdd BLAST92

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi340 – 354Poly-GlnAdd BLAST15

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the krueppel C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri74 – 96C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri174 – 196C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri202 – 224C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri232 – 255C2H2-type 4PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri261 – 283C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri287 – 308C2H2-type 6PROSITE-ProRule annotationAdd BLAST22

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1721, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155932

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q14119

Identification of Orthologs from Complete Genome Data

More...OMAi		VDSMPFL

Database of Orthologous Groups

More...OrthoDBi		1318335at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q14119

TreeFam database of animal gene trees

More...TreeFami		TF331686

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00096, zf-C2H2, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00355, ZnF_C2H2, 6 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF57667, SSF57667, 3 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00028, ZINC_FINGER_C2H2_1, 5 hits
PS50157, ZINC_FINGER_C2H2_2, 5 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q14119-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEANWTAFLF QAHEASHHQQ QAAQNSLLPL LSSAVEPPDQ KPLLPIPITQ 
        60         70         80         90        100
KPQGAPETLK DAIGIKKEKP KTSFVCTYCS KAFRDSYHLR RHESCHTGIK 
       110        120        130        140        150
LVSRPKKTPT TVVPLISTIA GDSSRTSLVS TIAGILSTVT TSSSGTNPSS 
       160        170        180        190        200
SASTTAMPVT QSVKKPSKPV KKNHACEMCG KAFRDVYHLN RHKLSHSDEK 
       210        220        230        240        250
PFECPICNQR FKRKDRMTYH VRSHEGGITK PYTCSVCGKG FSRPDHLSCH 
       260        270        280        290        300
VKHVHSTERP FKCQTCTAAF ATKDRLRTHM VRHEGKVSCN ICGKLLSAAY 
       310        320        330        340        350
ITSHLKTHGQ SQSINCNTCK QGISKTCMSE ETSNQKQQQQ QQQQQQQQQQ 
       360        370        380        390        400
QQQQHVTSWP GKQVETLRLW EEAVKARKKE AANLCQTSTA ATTPVTLTTP 
       410        420        430        440        450
FSITSSVSSG TMSNPVTVAA AMSMRSPVNV SSAVNITSPM NIGHPVTITS 
       460        470        480        490        500
PLSMTSPLTL TTPVNLPTPV TAPVNIAHPV TITSPMNLPT PMTLAAPLNI 
       510        520 
AMRPVESMPF LPQALPTSPP W
Length:521
Mass (Da):56,931
Last modified:January 11, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB16095D95094E385
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3QSH4J3QSH4_HUMAN
Vascular endothelial zinc finger 1
VEZF1
512Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J9JIC7J9JIC7_HUMAN
Vascular endothelial zinc finger 1
VEZF1
340Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QLN5J3QLN5_HUMAN
Vascular endothelial zinc finger 1
VEZF1
16Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti350 – 354Missing in BAA05663 (PubMed:8035792).Curated5
Sequence conflicti410G → E in BAA05663 (PubMed:8035792).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
D28118 mRNA Translation: BAA05663.1
AC015813 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS32687.1

Protein sequence database of the Protein Information Resource

More...PIRi		A53772

NCBI Reference Sequences

More...RefSeqi		NP_009077.2, NM_007146.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000581208; ENSP00000462337; ENSG00000136451

Database of genes from NCBI RefSeq genomes

More...GeneIDi		7716

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:7716

UCSC genome browser

More...UCSCi		uc002ivf.2, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D28118 mRNA Translation: BAA05663.1
AC015813 Genomic DNA No translation available.
CCDSiCCDS32687.1
PIRiA53772
RefSeqiNP_009077.2, NM_007146.2

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi113509, 73 interactors
IntActiQ14119, 63 interactors
STRINGi9606.ENSP00000462337

PTM databases

GlyGeniQ14119, 5 sites, 1 O-linked glycan (5 sites)
iPTMnetiQ14119
PhosphoSitePlusiQ14119

Polymorphism and mutation databases

BioMutaiVEZF1
DMDMi317373301

Proteomic databases

EPDiQ14119
jPOSTiQ14119
MassIVEiQ14119
MaxQBiQ14119
PaxDbiQ14119
PeptideAtlasiQ14119
PRIDEiQ14119
ProteomicsDBi59826

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		18343, 102 antibodies

The DNASU plasmid repository

More...DNASUi		7716

Genome annotation databases

EnsembliENST00000581208; ENSP00000462337; ENSG00000136451
GeneIDi7716
KEGGihsa:7716
UCSCiuc002ivf.2, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		7716
DisGeNETi7716
EuPathDBiHostDB:ENSG00000136451.8

GeneCards: human genes, protein and diseases

More...GeneCardsi		VEZF1
HGNCiHGNC:12949, VEZF1
HPAiENSG00000136451, Low tissue specificity
MIMi606747, gene
neXtProtiNX_Q14119
OpenTargetsiENSG00000136451
PharmGKBiPA162408823

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1721, Eukaryota
GeneTreeiENSGT00940000155932
InParanoidiQ14119
OMAiVDSMPFL
OrthoDBi1318335at2759
PhylomeDBiQ14119
TreeFamiTF331686

Enzyme and pathway databases

PathwayCommonsiQ14119

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		7716, 73 hits in 894 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		VEZF1, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		7716
PharosiQ14119, Tbio

Protein Ontology

More...PROi		PR:Q14119
RNActiQ14119, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000136451, Expressed in epithelium of mammary gland and 245 other tissues
ExpressionAtlasiQ14119, baseline and differential
GenevisibleiQ14119, HS

Family and domain databases

InterProiView protein in InterPro
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type
PfamiView protein in Pfam
PF00096, zf-C2H2, 3 hits
SMARTiView protein in SMART
SM00355, ZnF_C2H2, 6 hits
SUPFAMiSSF57667, SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS00028, ZINC_FINGER_C2H2_1, 5 hits
PS50157, ZINC_FINGER_C2H2_2, 5 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiVEZF1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q14119
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: January 11, 2011
Last modified: October 7, 2020
This is version 182 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again