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Protein

Vascular endothelial zinc finger 1

Gene

VEZF1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Possible transcription factor. Specifically binds to the CT/GC-rich region of the interleukin-3 promoter and mediates tax transactivation of IL-3.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri74 – 96C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri174 – 196C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri202 – 224C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri232 – 255C2H2-type 4PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri261 – 283C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri287 – 308C2H2-type 6PROSITE-ProRule annotationAdd BLAST22

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Vascular endothelial zinc finger 1
Alternative name(s):
Putative transcription factor DB1
Zinc finger protein 161
Gene namesi
Name:VEZF1
Synonyms:DB1, ZNF161
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000136451.8
HGNCiHGNC:12949 VEZF1
MIMi606747 gene
neXtProtiNX_Q14119

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi7716
OpenTargetsiENSG00000136451
PharmGKBiPA162408823

Polymorphism and mutation databases

BioMutaiVEZF1
DMDMi317373301

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000474351 – 521Vascular endothelial zinc finger 1Add BLAST521

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei362N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ14119
MaxQBiQ14119
PaxDbiQ14119
PeptideAtlasiQ14119
PRIDEiQ14119
ProteomicsDBi59826

PTM databases

iPTMnetiQ14119
PhosphoSitePlusiQ14119

Expressioni

Tissue specificityi

Ubiquitously expressed. Highest levels in skeletal muscle and kidney.1 Publication

Gene expression databases

BgeeiENSG00000136451 Expressed in 232 organ(s), highest expression level in epithelium of mammary gland
CleanExiHS_VEZF1
ExpressionAtlasiQ14119 baseline and differential
GenevisibleiQ14119 HS

Organism-specific databases

HPAiHPA027520
HPA048315

Interactioni

Subunit structurei

Interacts with ARHGAP22.By similarity

Protein-protein interaction databases

BioGridi113509, 5 interactors
IntActiQ14119, 57 interactors
STRINGi9606.ENSP00000462337

Structurei

3D structure databases

ProteinModelPortaliQ14119
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati394 – 40017
Repeati445 – 45127
Repeati457 – 46337
Repeati479 – 48547

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni394 – 4854 X 7 AA repeats of P-[LV]-T-[IL]-T-[ST]-PAdd BLAST92

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi340 – 354Poly-GlnAdd BLAST15

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri74 – 96C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri174 – 196C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri202 – 224C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri232 – 255C2H2-type 4PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri261 – 283C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri287 – 308C2H2-type 6PROSITE-ProRule annotationAdd BLAST22

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00530000063522
HOGENOMiHOG000294183
HOVERGENiHBG058083
InParanoidiQ14119
OMAiKQGINKT
OrthoDBiEOG091G06L9
PhylomeDBiQ14119
TreeFamiTF331686

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 3 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 6 hits
SUPFAMiSSF57667 SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 5 hits
PS50157 ZINC_FINGER_C2H2_2, 5 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q14119-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEANWTAFLF QAHEASHHQQ QAAQNSLLPL LSSAVEPPDQ KPLLPIPITQ
60 70 80 90 100
KPQGAPETLK DAIGIKKEKP KTSFVCTYCS KAFRDSYHLR RHESCHTGIK
110 120 130 140 150
LVSRPKKTPT TVVPLISTIA GDSSRTSLVS TIAGILSTVT TSSSGTNPSS
160 170 180 190 200
SASTTAMPVT QSVKKPSKPV KKNHACEMCG KAFRDVYHLN RHKLSHSDEK
210 220 230 240 250
PFECPICNQR FKRKDRMTYH VRSHEGGITK PYTCSVCGKG FSRPDHLSCH
260 270 280 290 300
VKHVHSTERP FKCQTCTAAF ATKDRLRTHM VRHEGKVSCN ICGKLLSAAY
310 320 330 340 350
ITSHLKTHGQ SQSINCNTCK QGISKTCMSE ETSNQKQQQQ QQQQQQQQQQ
360 370 380 390 400
QQQQHVTSWP GKQVETLRLW EEAVKARKKE AANLCQTSTA ATTPVTLTTP
410 420 430 440 450
FSITSSVSSG TMSNPVTVAA AMSMRSPVNV SSAVNITSPM NIGHPVTITS
460 470 480 490 500
PLSMTSPLTL TTPVNLPTPV TAPVNIAHPV TITSPMNLPT PMTLAAPLNI
510 520
AMRPVESMPF LPQALPTSPP W
Length:521
Mass (Da):56,931
Last modified:January 11, 2011 - v2
Checksum:iB16095D95094E385
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3QSH4J3QSH4_HUMAN
Vascular endothelial zinc finger 1
VEZF1
512Annotation score:
J9JIC7J9JIC7_HUMAN
Vascular endothelial zinc finger 1
VEZF1
340Annotation score:
J3QLN5J3QLN5_HUMAN
Vascular endothelial zinc finger 1
VEZF1
16Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti350 – 354Missing in BAA05663 (PubMed:8035792).Curated5
Sequence conflicti410G → E in BAA05663 (PubMed:8035792).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D28118 mRNA Translation: BAA05663.1
AC015813 Genomic DNA No translation available.
CCDSiCCDS32687.1
PIRiA53772
RefSeqiNP_009077.2, NM_007146.2
UniGeneiHs.463569

Genome annotation databases

EnsembliENST00000581208; ENSP00000462337; ENSG00000136451
GeneIDi7716
KEGGihsa:7716
UCSCiuc002ivf.2 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D28118 mRNA Translation: BAA05663.1
AC015813 Genomic DNA No translation available.
CCDSiCCDS32687.1
PIRiA53772
RefSeqiNP_009077.2, NM_007146.2
UniGeneiHs.463569

3D structure databases

ProteinModelPortaliQ14119
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113509, 5 interactors
IntActiQ14119, 57 interactors
STRINGi9606.ENSP00000462337

PTM databases

iPTMnetiQ14119
PhosphoSitePlusiQ14119

Polymorphism and mutation databases

BioMutaiVEZF1
DMDMi317373301

Proteomic databases

EPDiQ14119
MaxQBiQ14119
PaxDbiQ14119
PeptideAtlasiQ14119
PRIDEiQ14119
ProteomicsDBi59826

Protocols and materials databases

DNASUi7716
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000581208; ENSP00000462337; ENSG00000136451
GeneIDi7716
KEGGihsa:7716
UCSCiuc002ivf.2 human

Organism-specific databases

CTDi7716
DisGeNETi7716
EuPathDBiHostDB:ENSG00000136451.8
GeneCardsiVEZF1
HGNCiHGNC:12949 VEZF1
HPAiHPA027520
HPA048315
MIMi606747 gene
neXtProtiNX_Q14119
OpenTargetsiENSG00000136451
PharmGKBiPA162408823
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00530000063522
HOGENOMiHOG000294183
HOVERGENiHBG058083
InParanoidiQ14119
OMAiKQGINKT
OrthoDBiEOG091G06L9
PhylomeDBiQ14119
TreeFamiTF331686

Miscellaneous databases

ChiTaRSiVEZF1 human
GenomeRNAii7716
PROiPR:Q14119
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000136451 Expressed in 232 organ(s), highest expression level in epithelium of mammary gland
CleanExiHS_VEZF1
ExpressionAtlasiQ14119 baseline and differential
GenevisibleiQ14119 HS

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 3 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 6 hits
SUPFAMiSSF57667 SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 5 hits
PS50157 ZINC_FINGER_C2H2_2, 5 hits
ProtoNetiSearch...

Entry informationi

Entry nameiVEZF1_HUMAN
AccessioniPrimary (citable) accession number: Q14119
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: January 11, 2011
Last modified: October 10, 2018
This is version 168 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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