Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 177 (08 May 2019)
Sequence version 1 (01 Nov 1996)
Previous versions | rss
Other tutorials and videosHelp videoFeedback
Protein

Interleukin-18

Gene

IL18

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

A proinflammatory cytokine primarily involved in polarized T-helper 1 (Th1) cell and natural killer (NK) cell immune responses (Probable). Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators (PubMed:14528293, PubMed:25500532). Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells and natural killer (NK) cells (Probable) (PubMed:10653850).Curated3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCytokine
Biological processInflammatory response

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-448706 Interleukin-1 processing
R-HSA-6783783 Interleukin-10 signaling
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling
R-HSA-9012546 Interleukin-18 signaling

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q14116

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Interleukin-183 Publications
Short name:
IL-183 Publications
Alternative name(s):
Iboctadekin
Interferon gamma-inducing factor2 Publications
Short name:
IFN-gamma-inducing factor2 Publications
Interleukin-1 gamma
Short name:
IL-1 gamma
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:IL18Imported
Synonyms:IGIF, IL1F4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:5986 IL18

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
600953 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q14116

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi40K → A: Reduces binding to IL18R1 and the ability to induce IFNG production. 1 Publication1
Mutagenesisi41L → A: Impairs binding to IL18R1 and the ability to induce IFNG production. 1 Publication1
Mutagenesisi44K → A: Reduces binding to IL18R1 and the ability to induce IFNG production. 1 Publication1
Mutagenesisi49R → A: Reduces binding to IL18R1 and the ability to induce IFNG production. 1 Publication1
Mutagenesisi53D → A: Reduces binding to IL18R1 and the ability to induce IFNG production. 1 Publication1
Mutagenesisi69M → A: Impairs binding to IL18R1 and the ability to induce IFNG production. 1 Publication1
Mutagenesisi71D → A: Impairs binding to IL18R1 and the ability to induce IFNG production. 1 Publication1
Mutagenesisi94R → A: Impairs binding to IL18R1 and the ability to induce IFNG production. 1 Publication1
Mutagenesisi96M → A: Impairs binding to IL18R1 and the ability to induce IFNG production. 1 Publication1
Mutagenesisi115K → A: Reduces binding of the preformed binary complex of IL18 and IL18R1 to IL18RAP resulting in impaired IFNG production. 1 Publication1
Mutagenesisi120K → A: Reduces binding of the preformed binary complex of IL18 and IL18R1 to IL18RAP resulting in impaired IFNG production. 1 Publication1
Mutagenesisi134D → A: Reduces binding of the preformed binary complex of IL18 and IL18R1 to IL18RAP resulting in impaired IFNG production. 1 Publication1
Mutagenesisi140R → A: Reduces binding to IL18R1 and the ability to induce IFNG production. 1 Publication1
Mutagenesisi144G → A: Abolishes binding of the preformed binary complex of IL18 and IL18R1 to IL18RAP. 1 Publication1
Mutagenesisi145H → A: Abolishes binding of the preformed binary complex of IL18 and IL18R1 to IL18RAP. 1 Publication1
Mutagenesisi146D → A: Reduces binding of the preformed binary complex of IL18 and IL18R1 to IL18RAP. 1 Publication1
Mutagenesisi148K → A: Abolishes binding of the preformed binary complex of IL18 and IL18R1 to IL18RAP. 1 Publication1
Mutagenesisi168D → A: Reduces binding to IL18R1 and the ability to induce IFNG production. 1 Publication1
Mutagenesisi183R → A: Reduces binding of the preformed binary complex of IL18 and IL18R1 to IL18RAP. 1 Publication1
Mutagenesisi186M → A: Reduces binding of the preformed binary complex of IL18 and IL18R1 to IL18RAP. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
3606

Open Targets

More...
OpenTargetsi
ENSG00000150782

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA29802

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL1741305

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
IL18

Domain mapping of disease mutations (DMDM)

More...
DMDMi
3219817

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_00000153431 – 36By similarityAdd BLAST36
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001534437 – 193Interleukin-18Add BLAST157

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

The pro-IL-18 precursor is processed by CASP1 or CASP4 to yield the active form.2 Publications

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q14116

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q14116

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q14116

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q14116

PeptideAtlas

More...
PeptideAtlasi
Q14116

PRoteomics IDEntifications database

More...
PRIDEi
Q14116

ProteomicsDB human proteome resource

More...
ProteomicsDBi
59823

2D gel databases

USC-OGP 2-DE database

More...
OGPi
Q14116

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q14116

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q14116

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
Q14116

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

In macrophages, release is increased by endocannabinoid anandamide/AEA.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000150782 Expressed in 194 organ(s), highest expression level in lower esophagus mucosa

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q14116 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q14116 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB007772
HPA003980

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Forms a ternary complex with ligand-binding receptor subunit IL18R1 and signaling receptor subunit IL18RAP at the plasma membrane. Mature IL18 first binds to IL18R1 forming a low affinity binary complex, which then interacts with IL18RAP to form a high affinity ternary complex that signals inside the cell (PubMed:25261253, PubMed:14528293, PubMed:25500532).3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
109819, 12 interactors

Database of interacting proteins

More...
DIPi
DIP-3785N

Protein interaction database and analysis system

More...
IntActi
Q14116, 5 interactors

Molecular INTeraction database

More...
MINTi
Q14116

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000280357

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1193
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1J0SNMR-A37-193[»]
2VXTX-ray1.49I37-193[»]
3F62X-ray2.00B37-193[»]
3WO2X-ray2.33A/B/C/D37-193[»]
3WO3X-ray3.10A/C/E/G/I/K37-193[»]
3WO4X-ray3.10A37-193[»]
4EEEX-ray2.71B/D37-193[»]
4EKXX-ray1.75B/D37-193[»]
4HJJX-ray2.10A37-192[»]
4R6UX-ray2.80B/D37-193[»]
4XFSX-ray1.91A/B37-193[»]
4XFTX-ray2.00A/B37-193[»]
4XFUX-ray2.85A/B37-193[»]

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q14116

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q14116

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the IL-1 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410J3U9 Eukaryota
ENOG410ZGS8 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000001053

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000048723

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q14116

KEGG Orthology (KO)

More...
KOi
K05482

Identification of Orthologs from Complete Genome Data

More...
OMAi
LESDHFG

Database of Orthologous Groups

More...
OrthoDBi
1190337at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q14116

TreeFam database of animal gene trees

More...
TreeFami
TF336297

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR015529 IL-18
IPR000975 IL-1_fam
IPR008996 IL1/FGF

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00340 IL1, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF015162 Interleukin_18, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01933 INTRLEUKIN18

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50353 SSF50353, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q14116-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAEPVEDNC INFVAMKFID NTLYFIAEDD ENLESDYFGK LESKLSVIRN
60 70 80 90 100
LNDQVLFIDQ GNRPLFEDMT DSDCRDNAPR TIFIISMYKD SQPRGMAVTI
110 120 130 140 150
SVKCEKISTL SCENKIISFK EMNPPDNIKD TKSDIIFFQR SVPGHDNKMQ
160 170 180 190
FESSSYEGYF LACEKERDLF KLILKKEDEL GDRSIMFTVQ NED
Length:193
Mass (Da):22,326
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i323C62C203788D55
GO
Isoform 2 (identifier: Q14116-2) [UniParc]FASTAAdd to basket
Also known as: Delta3pro-IL-18

The sequence of this isoform differs from the canonical sequence as follows:
     27-30: Missing.

Note: Expressed in ovarian carcinoma but undetectable in normal ovarian epithelial cells. Resistant to proteolytic activation by caspase-1 and -4.
Show »
Length:189
Mass (Da):21,896
Checksum:iA8BA275CF713A4B6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti66F → L in AAC27787 (Ref. 3) Curated1
Sequence conflicti86S → R in AAC27787 (Ref. 3) Curated1
Sequence conflicti191N → S in AAC27787 (Ref. 3) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_04493427 – 30Missing in isoform 2. 1 Publication4

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
D49950 mRNA Translation: BAA08706.1
AY266351 mRNA Translation: AAP92112.1
AF077611 mRNA Translation: AAC27787.1
AY044641 mRNA Translation: AAK95950.1
CR541973 mRNA Translation: CAG46771.1
CR542001 mRNA Translation: CAG46798.1
AP002007 Genomic DNA No translation available.
AP002884 Genomic DNA No translation available.
CH471065 Genomic DNA Translation: EAW67184.1
BC007007 mRNA Translation: AAH07007.1
BC007461 mRNA Translation: AAH07461.1
U90434 mRNA Translation: AAB50010.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS44731.1 [Q14116-1]
CCDS58180.1 [Q14116-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001230140.1, NM_001243211.1 [Q14116-2]
NP_001553.1, NM_001562.3 [Q14116-1]
XP_011541107.1, XM_011542805.1 [Q14116-2]
XP_011541108.1, XM_011542806.2 [Q14116-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000280357; ENSP00000280357; ENSG00000150782 [Q14116-1]
ENST00000524595; ENSP00000434561; ENSG00000150782 [Q14116-2]
ENST00000528832; ENSP00000434161; ENSG00000150782 [Q14116-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
3606

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:3606

UCSC genome browser

More...
UCSCi
uc001pnb.2 human [Q14116-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Wikipedia

Interleukin-1 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D49950 mRNA Translation: BAA08706.1
AY266351 mRNA Translation: AAP92112.1
AF077611 mRNA Translation: AAC27787.1
AY044641 mRNA Translation: AAK95950.1
CR541973 mRNA Translation: CAG46771.1
CR542001 mRNA Translation: CAG46798.1
AP002007 Genomic DNA No translation available.
AP002884 Genomic DNA No translation available.
CH471065 Genomic DNA Translation: EAW67184.1
BC007007 mRNA Translation: AAH07007.1
BC007461 mRNA Translation: AAH07461.1
U90434 mRNA Translation: AAB50010.1
CCDSiCCDS44731.1 [Q14116-1]
CCDS58180.1 [Q14116-2]
RefSeqiNP_001230140.1, NM_001243211.1 [Q14116-2]
NP_001553.1, NM_001562.3 [Q14116-1]
XP_011541107.1, XM_011542805.1 [Q14116-2]
XP_011541108.1, XM_011542806.2 [Q14116-1]

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1J0SNMR-A37-193[»]
2VXTX-ray1.49I37-193[»]
3F62X-ray2.00B37-193[»]
3WO2X-ray2.33A/B/C/D37-193[»]
3WO3X-ray3.10A/C/E/G/I/K37-193[»]
3WO4X-ray3.10A37-193[»]
4EEEX-ray2.71B/D37-193[»]
4EKXX-ray1.75B/D37-193[»]
4HJJX-ray2.10A37-192[»]
4R6UX-ray2.80B/D37-193[»]
4XFSX-ray1.91A/B37-193[»]
4XFTX-ray2.00A/B37-193[»]
4XFUX-ray2.85A/B37-193[»]
SMRiQ14116
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109819, 12 interactors
DIPiDIP-3785N
IntActiQ14116, 5 interactors
MINTiQ14116
STRINGi9606.ENSP00000280357

Chemistry databases

ChEMBLiCHEMBL1741305

PTM databases

iPTMnetiQ14116
PhosphoSitePlusiQ14116

Polymorphism and mutation databases

BioMutaiIL18
DMDMi3219817

2D gel databases

OGPiQ14116

Proteomic databases

EPDiQ14116
jPOSTiQ14116
MaxQBiQ14116
PaxDbiQ14116
PeptideAtlasiQ14116
PRIDEiQ14116
ProteomicsDBi59823

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
3606
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000280357; ENSP00000280357; ENSG00000150782 [Q14116-1]
ENST00000524595; ENSP00000434561; ENSG00000150782 [Q14116-2]
ENST00000528832; ENSP00000434161; ENSG00000150782 [Q14116-1]
GeneIDi3606
KEGGihsa:3606
UCSCiuc001pnb.2 human [Q14116-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3606
DisGeNETi3606

GeneCards: human genes, protein and diseases

More...
GeneCardsi
IL18
HGNCiHGNC:5986 IL18
HPAiCAB007772
HPA003980
MIMi600953 gene
neXtProtiNX_Q14116
OpenTargetsiENSG00000150782
PharmGKBiPA29802

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410J3U9 Eukaryota
ENOG410ZGS8 LUCA
GeneTreeiENSGT00390000001053
HOGENOMiHOG000048723
InParanoidiQ14116
KOiK05482
OMAiLESDHFG
OrthoDBi1190337at2759
PhylomeDBiQ14116
TreeFamiTF336297

Enzyme and pathway databases

ReactomeiR-HSA-448706 Interleukin-1 processing
R-HSA-6783783 Interleukin-10 signaling
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling
R-HSA-9012546 Interleukin-18 signaling
SIGNORiQ14116

Miscellaneous databases

EvolutionaryTraceiQ14116

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Interleukin_18

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
3606
PMAP-CutDBiQ14116

Protein Ontology

More...
PROi
PR:Q14116

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000150782 Expressed in 194 organ(s), highest expression level in lower esophagus mucosa
ExpressionAtlasiQ14116 baseline and differential
GenevisibleiQ14116 HS

Family and domain databases

InterProiView protein in InterPro
IPR015529 IL-18
IPR000975 IL-1_fam
IPR008996 IL1/FGF
PfamiView protein in Pfam
PF00340 IL1, 1 hit
PIRSFiPIRSF015162 Interleukin_18, 1 hit
PRINTSiPR01933 INTRLEUKIN18
SUPFAMiSSF50353 SSF50353, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIL18_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q14116
Secondary accession number(s): O75599, Q6FGY3, Q6WWJ7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: May 8, 2019
This is version 177 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again