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UniProtKB - Q14114 (LRP8_HUMAN)

Entry version 202 (23 Feb 2022)
Sequence version 4 (22 Sep 2009)
Previous versions | rss
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Protein

Low-density lipoprotein receptor-related protein 8

Gene

LRP8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Cell surface receptor for Reelin (RELN) and apolipoprotein E (apoE)-containing ligands. LRP8 participates in transmitting the extracellular Reelin signal to intracellular signaling processes, by binding to DAB1 on its cytoplasmic tail. Reelin acts via both the VLDL receptor (VLDLR) and LRP8 to regulate DAB1 tyrosine phosphorylation and microtubule function in neurons. LRP8 has higher affinity for Reelin than VLDLR. LRP8 is thus a key component of the Reelin pathway which governs neuronal layering of the forebrain during embryonic brain development. Binds the endoplasmic reticulum resident receptor-associated protein (RAP). Binds dimers of beta 2-glycoprotein I and may be involved in the suppression of platelet aggregation in the vasculature. Highly expressed in the initial segment of the epididymis, where it affects the functional expression of clusterin and phospholipid hydroperoxide glutathione peroxidase (PHGPx), two proteins required for sperm maturation. May also function as an endocytic receptor. Not required for endocytic uptake of SEPP1 in the kidney which is mediated by LRP2 (By similarity).

Together with its ligand, apolipoprotein E (apoE), may indirectly play a role in the suppression of the innate immune response by controlling the survival of myeloid-derived suppressor cells (By similarity).

By similarity3 Publications

Miscellaneous

Natural isoforms of apoE (E2, E3, E4) have similar affinities for LRP8.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor
Biological processEndocytosis
LigandCalcium

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q14114

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-432142, Platelet sensitization by LDL
R-HSA-975634, Retinoid metabolism and transport

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q14114

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q14114

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Low-density lipoprotein receptor-related protein 8
Short name:
LRP-8
Alternative name(s):
Apolipoprotein E receptor 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LRP8
Synonyms:APOER2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:6700, LRP8

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		602600, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q14114

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000157193

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini42 – 826ExtracellularSequence analysisAdd BLAST785
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei827 – 847HelicalSequence analysisAdd BLAST21
Topological domaini848 – 963CytoplasmicSequence analysisAdd BLAST116

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Myocardial infarction 1 (MCI1)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA condition defined by the irreversible necrosis of heart muscle secondary to prolonged ischemia.
Related information in OMIM

Organism-specific databases

DisGeNET

More...DisGeNETi		7804

MalaCards human disease database

More...MalaCardsi		LRP8
MIMi608446, phenotype

Open Targets

More...OpenTargetsi		ENSG00000157193

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA30457

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q14114, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		LRP8

Domain mapping of disease mutations (DMDM)

More...DMDMi		259016389

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 32Sequence analysisAdd BLAST32
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001733233 – 963Low-density lipoprotein receptor-related protein 8Add BLAST931

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi47 ↔ 59By similarity
Disulfide bondi54 ↔ 72By similarity
Disulfide bondi66 ↔ 81By similarity
Disulfide bondi86 ↔ 98By similarity
Disulfide bondi93 ↔ 111By similarity
Disulfide bondi105 ↔ 122By similarity
Disulfide bondi127 ↔ 141By similarity
Disulfide bondi134 ↔ 154By similarity
Disulfide bondi148 ↔ 163By similarity
Disulfide bondi167 ↔ 179By similarity
Disulfide bondi174 ↔ 192By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi176N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi186 ↔ 201By similarity
Disulfide bondi206 ↔ 221By similarity
Disulfide bondi213 ↔ 234By similarity
Disulfide bondi228 ↔ 245By similarity
Disulfide bondi259 ↔ 272By similarity
Disulfide bondi267 ↔ 285By similarity
Disulfide bondi279 ↔ 294By similarity
Disulfide bondi299 ↔ 311By similarity
Disulfide bondi306 ↔ 324By similarity
Disulfide bondi318 ↔ 333By similarity
Disulfide bondi340 ↔ 351By similarity
Disulfide bondi347 ↔ 360By similarity
Disulfide bondi362 ↔ 374By similarity
Disulfide bondi380 ↔ 390By similarity
Disulfide bondi386 ↔ 399By similarity
Disulfide bondi401 ↔ 414By similarity
Glycosylationi441N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi518N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi538N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi772N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi807N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

O-glycosylated. Some alternatively spliced isoforms lack the O-linked sugar domain (By similarity).By similarity
Undergoes sequential, furin and gamma-secretase dependent, proteolytic processing, resulting in the extracellular release of the entire ligand-binding domain as a soluble polypeptide and in the intracellular domain (ICD) release into the cytoplasm. The gamma-secretase-dependent proteolytical processing occurs after the bulk of the extracellular domain has been shed, in a furin-dependent manner, in alternatively spliced isoforms carrying the furin cleavage site. Hypoglycosylation (mainly hypo-O-glycosylation) leads to increased extracellular cleavage, which in turn results in accelerating release of the intracellular domain (ICD) by the gamma-secretase. The resulting receptor fragment is able to inhibit Reelin signaling and in particular the Reelin-induced DAB1 phosphorylation (By similarity).By similarity
Tyrosine phosphorylated upon apoE binding.1 Publication
Ubiquitinated by MYLIP leading to degradation.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q14114

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q14114

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q14114

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q14114

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q14114

PeptideAtlas

More...PeptideAtlasi		Q14114

PRoteomics IDEntifications database

More...PRIDEi		Q14114

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		59819 [Q14114-1]
59820 [Q14114-2]
59821 [Q14114-3]
59822 [Q14114-4]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q14114, 7 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q14114

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q14114

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q14114

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed mainly in brain and placenta. Also expressed in platelets and megakaryocytic cells. Not expressed in the liver.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000157193, Expressed in pigmented layer of retina and 214 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q14114, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q14114, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000157193, Tissue enhanced (testis, thyroid gland)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Reelin associates with two or more receptor molecules.

Interacts with DAB1 and JNK-interacting proteins.

Interacts with SNX17 (By similarity).

Interacts with PCSK9.

Interacts with MDK; this interaction is calcium dependent (By similarity).

By similarity1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		113579, 76 interactors

Database of interacting proteins

More...DIPi		DIP-48670N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...ELMi		Q14114

Protein interaction database and analysis system

More...IntActi		Q14114, 35 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000303634

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q14114, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1963
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q14114

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q14114

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini46 – 82LDL-receptor class A 1PROSITE-ProRule annotationAdd BLAST37
Domaini85 – 123LDL-receptor class A 2PROSITE-ProRule annotationAdd BLAST39
Domaini126 – 164LDL-receptor class A 3PROSITE-ProRule annotationAdd BLAST39
Domaini166 – 202LDL-receptor class A 4PROSITE-ProRule annotationAdd BLAST37
Domaini205 – 246LDL-receptor class A 5PROSITE-ProRule annotationAdd BLAST42
Domaini258 – 295LDL-receptor class A 6PROSITE-ProRule annotationAdd BLAST38
Domaini298 – 334LDL-receptor class A 7PROSITE-ProRule annotationAdd BLAST37
Domaini336 – 375EGF-like 1PROSITE-ProRule annotationAdd BLAST40
Domaini376 – 415EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd BLAST40
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati462 – 508LDL-receptor class B 1Add BLAST47
Repeati509 – 551LDL-receptor class B 2Add BLAST43
Repeati552 – 595LDL-receptor class B 3Add BLAST44
Repeati596 – 639LDL-receptor class B 4Add BLAST44
Repeati640 – 681LDL-receptor class B 5Add BLAST42

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni740 – 798Clustered O-linked oligosaccharidesAdd BLAST59
Regioni754 – 815DisorderedSequence analysisAdd BLAST62

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The cytoplasmic domain is involved in the binding of DAB1 and in the recruitment of JNK-interacting proteins. Isoforms, which lack part of the cytoplasmic domain, are unable to recruit members of the family of JNK interacting proteins (JIP) to the cytoplasmic tail (By similarity).By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the LDLR family.Curated

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1215, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000154819

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_008163_4_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q14114

Identification of Orthologs from Complete Genome Data

More...OMAi		PRKFQCK

Database of Orthologous Groups

More...OrthoDBi		359795at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q14114

TreeFam database of animal gene trees

More...TreeFami		TF351700

Family and domain databases

Conserved Domains Database

More...CDDi		cd00112, LDLa, 6 hits

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.120.10.30, 1 hit
4.10.400.10, 7 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011042, 6-blade_b-propeller_TolB-like
IPR001881, EGF-like_Ca-bd_dom
IPR000742, EGF-like_dom
IPR000152, EGF-type_Asp/Asn_hydroxyl_site
IPR018097, EGF_Ca-bd_CS
IPR036055, LDL_receptor-like_sf
IPR023415, LDLR_class-A_CS
IPR000033, LDLR_classB_rpt
IPR002172, LDrepeatLR_classA_rpt

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00057, Ldl_recept_a, 7 hits
PF00058, Ldl_recept_b, 5 hits

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00261, LDLRECEPTOR

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00181, EGF, 4 hits
SM00179, EGF_CA, 2 hits
SM00192, LDLa, 7 hits
SM00135, LY, 5 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF57424, SSF57424, 7 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00010, ASX_HYDROXYL, 2 hits
PS01186, EGF_2, 2 hits
PS50026, EGF_3, 2 hits
PS01187, EGF_CA, 1 hit
PS01209, LDLRA_1, 7 hits
PS50068, LDLRA_2, 7 hits
PS51120, LDLRB, 5 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist. No differences were observed in the pattern splicing between control and Alzheimer brains.

This entry has 5 described isoforms and 22 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q14114-1) [UniParc]FASTAAdd to basket
Also known as: ApoER2 922

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGLPEPGPLR LLALLLLLLL LLLLQLQHLA AAAADPLLGG QGPAKDCEKD 
        60         70         80         90        100
QFQCRNERCI PSVWRCDEDD DCLDHSDEDD CPKKTCADSD FTCDNGHCIH 
       110        120        130        140        150
ERWKCDGEEE CPDGSDESEA TCTKQVCPAE KLSCGPTSHK CVPASWRCDG 
       160        170        180        190        200
EKDCEGGADE AGCATLCAPH EFQCGNRSCL AAVFVCDGDD DCGDGSDERG 
       210        220        230        240        250
CADPACGPRE FRCGGDGGGA CIPERWVCDR QFDCEDRSDE AAELCGRPGP 
       260        270        280        290        300
GATSAPAACA TASQFACRSG ECVHLGWRCD GDRDCKDKSD EADCPLGTCR 
       310        320        330        340        350
GDEFQCGDGT CVLAIKHCNQ EQDCPDGSDE AGCLQGLNEC LHNNGGCSHI 
       360        370        380        390        400
CTDLKIGFEC TCPAGFQLLD QKTCGDIDEC KDPDACSQIC VNYKGYFKCE 
       410        420        430        440        450
CYPGYEMDLL TKNCKAAAGK SPSLIFTNRH EVRRIDLVKR NYSRLIPMLK 
       460        470        480        490        500
NVVALDVEVA TNRIYWCDLS YRKIYSAYMD KASDPKEQEV LIDEQLHSPE 
       510        520        530        540        550
GLAVDWVHKH IYWTDSGNKT ISVATVDGGR RRTLFSRNLS EPRAIAVDPL 
       560        570        580        590        600
RGFMYWSDWG DQAKIEKSGL NGVDRQTLVS DNIEWPNGIT LDLLSQRLYW 
       610        620        630        640        650
VDSKLHQLSS IDFSGGNRKT LISSTDFLSH PFGIAVFEDK VFWTDLENEA 
       660        670        680        690        700
IFSANRLNGL EISILAENLN NPHDIVIFHE LKQPRAPDAC ELSVQPNGGC 
       710        720        730        740        750
EYLCLPAPQI SSHSPKYTCA CPDTMWLGPD MKRCYRAPQS TSTTTLASTM 
       760        770        780        790        800
TRTVPATTRA PGTTVHRSTY QNHSTETPSL TAAVPSSVSV PRAPSISPST 
       810        820        830        840        850
LSPATSNHSQ HYANEDSKMG STVTAAVIGI IVPIVVIALL CMSGYLIWRN 
       860        870        880        890        900
WKRKNTKSMN FDNPVYRKTT EEEDEDELHI GRTAQIGHVY PAAISSFDRP 
       910        920        930        940        950
LWAEPCLGET REPEDPAPAL KELFVLPGEP RSQLHQLPKN PLSELPVVKS 
       960 
KRVALSLEDD GLP
Length:963
Mass (Da):105,634
Last modified:September 22, 2009 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB10DCF72F62DE71C
GO
Isoform 2 (identifier: Q14114-2) [UniParc]FASTAAdd to basket
Also known as: ApoER2 906

The sequence of this isoform differs from the canonical sequence as follows:
     166-295: LCAPHEFQCG...KDKSDEADCP → S
     737-812: APQSTSTTTL...PATSNHSQHY → D
     893-951: Missing.

Show »
Length:700
Mass (Da):77,845
Checksum:iB996C9CAEC69C1E9
GO
Isoform 3 (identifier: Q14114-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     893-951: Missing.

Show »
Length:904
Mass (Da):99,092
Checksum:i043E708314261E3C
GO
Isoform 4 (identifier: Q14114-4) [UniParc]FASTAAdd to basket
Also known as: ApoER2delta4-7

The sequence of this isoform differs from the canonical sequence as follows:
     166-166: L → W
     167-336: Missing.

Show »
Length:793
Mass (Da):87,959
Checksum:i1A414B09D40BA1BC
GO
Isoform 5 (identifier: Q14114-5)
Sequence is not available
Note: Contains an insert in the extracellular part which carries a furin cleavage site.Curated
Length:–
Mass (Da):–

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 22 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PP15E9PP15_HUMAN
Low-density lipoprotein receptor-re...
LRP8
841Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A590UJ98A0A590UJ98_HUMAN
Low-density lipoprotein receptor-re...
LRP8
834Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A590UJF9A0A590UJF9_HUMAN
Low-density lipoprotein receptor-re...
LRP8
926Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A590UJJ8A0A590UJJ8_HUMAN
Low-density lipoprotein receptor-re...
LRP8
732Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A590UJT0A0A590UJT0_HUMAN
Low-density lipoprotein receptor-re...
LRP8
708Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A590UK97A0A590UK97_HUMAN
Low-density lipoprotein receptor-re...
LRP8
790Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A590UK84A0A590UK84_HUMAN
Low-density lipoprotein receptor-re...
LRP8
766Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A590UJ57A0A590UJ57_HUMAN
Low-density lipoprotein receptor-re...
LRP8
888Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A590UK45A0A590UK45_HUMAN
Low-density lipoprotein receptor-re...
LRP8
888Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A590UK53A0A590UK53_HUMAN
Low-density lipoprotein receptor-re...
LRP8
673Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAA99509 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti262A → V in BAA09328 (PubMed:8626535).Curated1
Sequence conflicti262A → V in BAA21824 (PubMed:9079678).Curated1
Sequence conflicti405Y → C in CAA99509 (PubMed:11152697).Curated1
Sequence conflicti418A → G in BAA09328 (PubMed:8626535).Curated1
Sequence conflicti418A → G in BAA21824 (PubMed:9079678).Curated1
Sequence conflicti418A → G in BAA21825 (PubMed:9079678).Curated1
Sequence conflicti430H → Y in BAA09328 (PubMed:8626535).Curated1
Sequence conflicti430H → Y in BAA21824 (PubMed:9079678).Curated1
Sequence conflicti430H → Y in BAA21825 (PubMed:9079678).Curated1
Sequence conflicti430H → Y in CAA99509 (PubMed:11152697).Curated1
Sequence conflicti488Q → R in CAA99509 (PubMed:11152697).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04697425Q → R4 PublicationsCorresponds to variant dbSNP:rs4926972Ensembl.1
Natural variantiVAR_01846846D → E5 PublicationsCorresponds to variant dbSNP:rs3820198Ensembl.1
Natural variantiVAR_037624453V → M. Corresponds to variant dbSNP:rs5180Ensembl.1
Natural variantiVAR_037625466W → C. Corresponds to variant dbSNP:rs5181Ensembl.1
Natural variantiVAR_037626607Q → R. Corresponds to variant dbSNP:rs5172EnsemblClinVar.1
Natural variantiVAR_037627611I → L. Corresponds to variant dbSNP:rs5170Ensembl.1
Natural variantiVAR_037628653S → T. Corresponds to variant dbSNP:rs5171Ensembl.1
Natural variantiVAR_059079736R → Q. Corresponds to variant dbSNP:rs5172EnsemblClinVar.1
Natural variantiVAR_018469952R → Q Associated with susceptibility to myocardial infarction type 1; increases activation of MAPK14 by oxidized low density lipoprotein. 2 PublicationsCorresponds to variant dbSNP:rs5174EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_010305166 – 295LCAPH…EADCP → S in isoform 2. 1 PublicationAdd BLAST130
Alternative sequenceiVSP_038181166L → W in isoform 4. Curated1
Alternative sequenceiVSP_010306167 – 336Missing in isoform 4. CuratedAdd BLAST170
Alternative sequenceiVSP_010307737 – 812APQST…HSQHY → D in isoform 2. 1 PublicationAdd BLAST76
Alternative sequenceiVSP_010308893 – 951Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST59

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
D50678 mRNA Translation: BAA09328.1
D86407 Genomic DNA Translation: BAA21824.1
D86407 Genomic DNA Translation: BAA21825.1
Z75190 mRNA Translation: CAA99509.1 Frameshift.
AL355483 Genomic DNA No translation available.
AL606760 Genomic DNA No translation available.
BC006443 mRNA Translation: AAH06443.1
BC051836 mRNA Translation: AAH51836.2

The Consensus CDS (CCDS) project

More...CCDSi		CCDS30720.1 [Q14114-3]
CCDS578.1 [Q14114-1]
CCDS579.1 [Q14114-2]
CCDS580.1 [Q14114-4]

NCBI Reference Sequences

More...RefSeqi		NP_001018064.1, NM_001018054.2 [Q14114-3]
NP_004622.2, NM_004631.4 [Q14114-1]
NP_059992.3, NM_017522.4 [Q14114-2]
NP_150643.2, NM_033300.3 [Q14114-4]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000306052; ENSP00000303634; ENSG00000157193
ENST00000347547; ENSP00000334522; ENSG00000157193 [Q14114-4]
ENST00000354412; ENSP00000346391; ENSG00000157193 [Q14114-2]
ENST00000371454; ENSP00000360509; ENSG00000157193 [Q14114-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		7804

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:7804

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000306052.12; ENSP00000303634.6; NM_004631.5; NP_004622.2

UCSC genome browser

More...UCSCi		uc001cvi.4, human [Q14114-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50678 mRNA Translation: BAA09328.1
D86407 Genomic DNA Translation: BAA21824.1
D86407 Genomic DNA Translation: BAA21825.1
Z75190 mRNA Translation: CAA99509.1 Frameshift.
AL355483 Genomic DNA No translation available.
AL606760 Genomic DNA No translation available.
BC006443 mRNA Translation: AAH06443.1
BC051836 mRNA Translation: AAH51836.2
CCDSiCCDS30720.1 [Q14114-3]
CCDS578.1 [Q14114-1]
CCDS579.1 [Q14114-2]
CCDS580.1 [Q14114-4]
RefSeqiNP_001018064.1, NM_001018054.2 [Q14114-3]
NP_004622.2, NM_004631.4 [Q14114-1]
NP_059992.3, NM_017522.4 [Q14114-2]
NP_150643.2, NM_033300.3 [Q14114-4]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3A7QX-ray2.60B42-83[»]
5B4XX-ray3.20B/D42-736[»]
5B4YX-ray1.90B42-124[»]
SMRiQ14114
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi113579, 76 interactors
DIPiDIP-48670N
ELMiQ14114
IntActiQ14114, 35 interactors
STRINGi9606.ENSP00000303634

PTM databases

GlyGeniQ14114, 7 sites
iPTMnetiQ14114
PhosphoSitePlusiQ14114
SwissPalmiQ14114

Genetic variation databases

BioMutaiLRP8
DMDMi259016389

Proteomic databases

EPDiQ14114
jPOSTiQ14114
MassIVEiQ14114
MaxQBiQ14114
PaxDbiQ14114
PeptideAtlasiQ14114
PRIDEiQ14114
ProteomicsDBi59819 [Q14114-1]
59820 [Q14114-2]
59821 [Q14114-3]
59822 [Q14114-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		33078, 419 antibodies from 33 providers

The DNASU plasmid repository

More...DNASUi		7804

Genome annotation databases

EnsembliENST00000306052; ENSP00000303634; ENSG00000157193
ENST00000347547; ENSP00000334522; ENSG00000157193 [Q14114-4]
ENST00000354412; ENSP00000346391; ENSG00000157193 [Q14114-2]
ENST00000371454; ENSP00000360509; ENSG00000157193 [Q14114-3]
GeneIDi7804
KEGGihsa:7804
MANE-SelectiENST00000306052.12; ENSP00000303634.6; NM_004631.5; NP_004622.2
UCSCiuc001cvi.4, human [Q14114-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		7804
DisGeNETi7804

GeneCards: human genes, protein and diseases

More...GeneCardsi		LRP8
HGNCiHGNC:6700, LRP8
HPAiENSG00000157193, Tissue enhanced (testis, thyroid gland)
MalaCardsiLRP8
MIMi602600, gene
608446, phenotype
neXtProtiNX_Q14114
OpenTargetsiENSG00000157193
PharmGKBiPA30457
VEuPathDBiHostDB:ENSG00000157193

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1215, Eukaryota
GeneTreeiENSGT00940000154819
HOGENOMiCLU_008163_4_0_1
InParanoidiQ14114
OMAiPRKFQCK
OrthoDBi359795at2759
PhylomeDBiQ14114
TreeFamiTF351700

Enzyme and pathway databases

PathwayCommonsiQ14114
ReactomeiR-HSA-432142, Platelet sensitization by LDL
R-HSA-975634, Retinoid metabolism and transport
SignaLinkiQ14114
SIGNORiQ14114

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		7804, 29 hits in 1044 CRISPR screens
EvolutionaryTraceiQ14114

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Low_density_lipoprotein_receptor-related_protein_8

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		7804
PharosiQ14114, Tbio

Protein Ontology

More...PROi		PR:Q14114
RNActiQ14114, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000157193, Expressed in pigmented layer of retina and 214 other tissues
ExpressionAtlasiQ14114, baseline and differential
GenevisibleiQ14114, HS

Family and domain databases

CDDicd00112, LDLa, 6 hits
Gene3Di2.120.10.30, 1 hit
4.10.400.10, 7 hits
InterProiView protein in InterPro
IPR011042, 6-blade_b-propeller_TolB-like
IPR001881, EGF-like_Ca-bd_dom
IPR000742, EGF-like_dom
IPR000152, EGF-type_Asp/Asn_hydroxyl_site
IPR018097, EGF_Ca-bd_CS
IPR036055, LDL_receptor-like_sf
IPR023415, LDLR_class-A_CS
IPR000033, LDLR_classB_rpt
IPR002172, LDrepeatLR_classA_rpt
PfamiView protein in Pfam
PF00057, Ldl_recept_a, 7 hits
PF00058, Ldl_recept_b, 5 hits
PRINTSiPR00261, LDLRECEPTOR
SMARTiView protein in SMART
SM00181, EGF, 4 hits
SM00179, EGF_CA, 2 hits
SM00192, LDLa, 7 hits
SM00135, LY, 5 hits
SUPFAMiSSF57424, SSF57424, 7 hits
PROSITEiView protein in PROSITE
PS00010, ASX_HYDROXYL, 2 hits
PS01186, EGF_2, 2 hits
PS50026, EGF_3, 2 hits
PS01187, EGF_CA, 1 hit
PS01209, LDLRA_1, 7 hits
PS50068, LDLRA_2, 7 hits
PS51120, LDLRB, 5 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLRP8_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q14114
Secondary accession number(s): B1AMT6
, B1AMT7, B1AMT8, O14968, Q86V27, Q99876, Q9BR78
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: September 22, 2009
Last modified: February 23, 2022
This is version 202 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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