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Protein

Protein Tob2

Gene

TOB2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Anti-proliferative protein inhibits cell cycle progression from the G0/G1 to S phases.

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Protein Tob2
Alternative name(s):
Protein Tob4
Transducer of erbB-2 2
Gene namesi
Name:TOB2
Synonyms:KIAA1663, TOB4, TROB2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

EuPathDBiHostDB:ENSG00000183864.4
HGNCiHGNC:11980 TOB2
MIMi607396 gene
neXtProtiNX_Q14106

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi10766
OpenTargetsiENSG00000183864
PharmGKBiPA36664

Polymorphism and mutation databases

BioMutaiTOB2
DMDMi12643431

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001438151 – 344Protein Tob2Add BLAST344

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei254PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ14106
MaxQBiQ14106
PaxDbiQ14106
PeptideAtlasiQ14106
PRIDEiQ14106
ProteomicsDBi59815

PTM databases

iPTMnetiQ14106
PhosphoSitePlusiQ14106

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiENSG00000183864 Expressed in 214 organ(s), highest expression level in paraflocculus
CleanExiHS_TOB2
ExpressionAtlasiQ14106 baseline and differential
GenevisibleiQ14106 HS

Organism-specific databases

HPAiHPA016603
HPA054112

Interactioni

Subunit structurei

Associates with CAF1.

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi115985, 14 interactors
DIPiDIP-41990N
ELMiQ14106
IntActiQ14106, 11 interactors
MINTiQ14106
STRINGi9606.ENSP00000331305

Structurei

3D structure databases

ProteinModelPortaliQ14106
SMRiQ14106
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the BTG family.Curated

Phylogenomic databases

eggNOGiKOG4006 Eukaryota
ENOG410ZZC0 LUCA
GeneTreeiENSGT00550000074461
HOGENOMiHOG000253939
HOVERGENiHBG006617
InParanoidiQ14106
KOiK14443
OMAiMQYPSQS
OrthoDBiEOG091G0LEQ
PhylomeDBiQ14106
TreeFamiTF105274

Family and domain databases

Gene3Di1.20.120.1120, 1 hit
InterProiView protein in InterPro
IPR002087 Anti_prolifrtn
IPR009818 Ataxin-2_C
IPR036054 BTG-like_sf
IPR015676 Tob1/2
IPR015678 Tob2
PANTHERiPTHR17537 PTHR17537, 1 hit
PTHR17537:SF3 PTHR17537:SF3, 1 hit
PfamiView protein in Pfam
PF07742 BTG, 1 hit
PF07145 PAM2, 2 hits
PRINTSiPR00310 ANTIPRLFBTG1
SMARTiView protein in SMART
SM00099 btg1, 1 hit
SUPFAMiSSF160696 SSF160696, 1 hit
PROSITEiView protein in PROSITE
PS00960 BTG_1, 1 hit
PS01203 BTG_2, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q14106-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MQLEIKVALN FIISYLYNKL PRRRADLFGE ELERLLKKKY EGHWYPEKPL
60 70 80 90 100
KGSGFRCVHI GEMVDPVVEL AAKRSGLAVE DVRANVPEEL SVWIDPFEVS
110 120 130 140 150
YQIGEKGAVK VLYLDDSEGC GAPELDKEIK SSFNPDAQVF VPIGSQDSSL
160 170 180 190 200
SNSPSPSFGQ SPSPTFIPRS AQPITFTTAS FAATKFGSTK MKKGGGAASG
210 220 230 240 250
GGVASSGAGG QQPPQQPRMA RSPTNSLLKH KSLSLSMHSL NFITANPAPQ
260 270 280 290 300
SQLSPNAKEF VYNGGGSPSL FFDAADGQGS GTPGPFGGSG AGTCNSSSFD
310 320 330 340
MAQVFGGGAN SLFLEKTPFV EGLSYNLNTM QYPSQQFQPV VLAN
Length:344
Mass (Da):36,632
Last modified:January 24, 2001 - v2
Checksum:iACE4CD8939641BD5
GO
Isoform 2 (identifier: Q14106-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     245-344: ANPAPQSQLS...QQFQPVVLAN → DYNHDQ

Note: No experimental confirmation available.
Show »
Length:250
Mass (Da):27,192
Checksum:i70F83F6D4DF29526
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B0QXZ4B0QXZ4_HUMAN
Protein Tob2
TOB2
101Annotation score:

Sequence cautioni

The sequence BAB33333 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti34 – 35RL → QA in BAA10971 (PubMed:10602502).Curated2
Sequence conflicti214P → H in BAA10971 (PubMed:10602502).Curated1
Sequence conflicti278 – 317QGSGT…FLEKT → RAAAPQARLEAVGLAPATAA ALTWPRYLEVVPTASSWRRH in BAA10971 (PubMed:10602502).CuratedAdd BLAST40

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_055557245 – 344ANPAP…VVLAN → DYNHDQ in isoform 2. 1 PublicationAdd BLAST100

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D64109 mRNA Translation: BAA10971.1
AB035207 mRNA Translation: BAA87042.1
AB051450 mRNA Translation: BAB33333.1 Different initiation.
CR456594 mRNA Translation: CAG30480.1
CR541684 mRNA Translation: CAG46485.1
AL008582 Genomic DNA No translation available.
BC028919 mRNA Translation: AAH28919.1
BC038957 mRNA Translation: AAH38957.1
CCDSiCCDS14015.1 [Q14106-1]
RefSeqiNP_057356.1, NM_016272.3 [Q14106-1]
XP_005261372.1, XM_005261315.2 [Q14106-1]
XP_006724168.1, XM_006724105.3 [Q14106-1]
XP_016884028.1, XM_017028539.1 [Q14106-1]
UniGeneiHs.474978

Genome annotation databases

EnsembliENST00000327492; ENSP00000331305; ENSG00000183864 [Q14106-1]
GeneIDi10766
KEGGihsa:10766
UCSCiuc003azz.2 human [Q14106-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D64109 mRNA Translation: BAA10971.1
AB035207 mRNA Translation: BAA87042.1
AB051450 mRNA Translation: BAB33333.1 Different initiation.
CR456594 mRNA Translation: CAG30480.1
CR541684 mRNA Translation: CAG46485.1
AL008582 Genomic DNA No translation available.
BC028919 mRNA Translation: AAH28919.1
BC038957 mRNA Translation: AAH38957.1
CCDSiCCDS14015.1 [Q14106-1]
RefSeqiNP_057356.1, NM_016272.3 [Q14106-1]
XP_005261372.1, XM_005261315.2 [Q14106-1]
XP_006724168.1, XM_006724105.3 [Q14106-1]
XP_016884028.1, XM_017028539.1 [Q14106-1]
UniGeneiHs.474978

3D structure databases

ProteinModelPortaliQ14106
SMRiQ14106
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115985, 14 interactors
DIPiDIP-41990N
ELMiQ14106
IntActiQ14106, 11 interactors
MINTiQ14106
STRINGi9606.ENSP00000331305

PTM databases

iPTMnetiQ14106
PhosphoSitePlusiQ14106

Polymorphism and mutation databases

BioMutaiTOB2
DMDMi12643431

Proteomic databases

EPDiQ14106
MaxQBiQ14106
PaxDbiQ14106
PeptideAtlasiQ14106
PRIDEiQ14106
ProteomicsDBi59815

Protocols and materials databases

DNASUi10766
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000327492; ENSP00000331305; ENSG00000183864 [Q14106-1]
GeneIDi10766
KEGGihsa:10766
UCSCiuc003azz.2 human [Q14106-1]

Organism-specific databases

CTDi10766
DisGeNETi10766
EuPathDBiHostDB:ENSG00000183864.4
GeneCardsiTOB2
HGNCiHGNC:11980 TOB2
HPAiHPA016603
HPA054112
MIMi607396 gene
neXtProtiNX_Q14106
OpenTargetsiENSG00000183864
PharmGKBiPA36664
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4006 Eukaryota
ENOG410ZZC0 LUCA
GeneTreeiENSGT00550000074461
HOGENOMiHOG000253939
HOVERGENiHBG006617
InParanoidiQ14106
KOiK14443
OMAiMQYPSQS
OrthoDBiEOG091G0LEQ
PhylomeDBiQ14106
TreeFamiTF105274

Miscellaneous databases

ChiTaRSiTOB2 human
GeneWikiiTOB2
GenomeRNAii10766
PROiPR:Q14106
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000183864 Expressed in 214 organ(s), highest expression level in paraflocculus
CleanExiHS_TOB2
ExpressionAtlasiQ14106 baseline and differential
GenevisibleiQ14106 HS

Family and domain databases

Gene3Di1.20.120.1120, 1 hit
InterProiView protein in InterPro
IPR002087 Anti_prolifrtn
IPR009818 Ataxin-2_C
IPR036054 BTG-like_sf
IPR015676 Tob1/2
IPR015678 Tob2
PANTHERiPTHR17537 PTHR17537, 1 hit
PTHR17537:SF3 PTHR17537:SF3, 1 hit
PfamiView protein in Pfam
PF07742 BTG, 1 hit
PF07145 PAM2, 2 hits
PRINTSiPR00310 ANTIPRLFBTG1
SMARTiView protein in SMART
SM00099 btg1, 1 hit
SUPFAMiSSF160696 SSF160696, 1 hit
PROSITEiView protein in PROSITE
PS00960 BTG_1, 1 hit
PS01203 BTG_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTOB2_HUMAN
AccessioniPrimary (citable) accession number: Q14106
Secondary accession number(s): Q6FHR7
, Q6PIT9, Q9BY97, Q9UBI0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 24, 2001
Last modified: September 12, 2018
This is version 147 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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