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Protein

Heterogeneous nuclear ribonucleoprotein D0

Gene

HNRNPD

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binds with high affinity to RNA molecules that contain AU-rich elements (AREs) found within the 3'-UTR of many proto-oncogenes and cytokine mRNAs. Also binds to double- and single-stranded DNA sequences in a specific manner and functions a transcription factor. Each of the RNA-binding domains specifically can bind solely to a single-stranded non-monotonous 5'-UUAG-3' sequence and also weaker to the single-stranded 5'-TTAGGG-3' telomeric DNA repeat. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats. Binding of RRM1 to DNA inhibits the formation of DNA quadruplex structure which may play a role in telomere elongation. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. May play a role in the regulation of the rhythmic expression of circadian clock core genes. Directly binds to the 3'UTR of CRY1 mRNA and induces CRY1 rhythmic translation. May also be involved in the regulation of PER2 translation.3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Ribonucleoprotein, RNA-binding
Biological processBiological rhythms, Transcription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA
R-HSA-72163 mRNA Splicing - Major Pathway
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q14103

Protein family/group databases

MoonDB Database of extreme multifunctional and moonlighting proteins

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MoonDBi
Q14103 Predicted

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Heterogeneous nuclear ribonucleoprotein D0
Short name:
hnRNP D0
Alternative name(s):
AU-rich element RNA-binding protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HNRNPD
Synonyms:AUF1, HNRPD
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000138668.18

Human Gene Nomenclature Database

More...
HGNCi
HGNC:5036 HNRNPD

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
601324 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q14103

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
3184

Open Targets

More...
OpenTargetsi
ENSG00000138668

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA29361

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
HNRNPD

Domain mapping of disease mutations (DMDM)

More...
DMDMi
13124489

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000818492 – 355Heterogeneous nuclear ribonucleoprotein D0Add BLAST354

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylserineCombined sources1
Modified residuei71PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki72Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei80PhosphoserineCombined sources1
Modified residuei82PhosphoserineCombined sources1
Modified residuei83PhosphoserineCombined sources1
Modified residuei91PhosphothreonineCombined sources1
Modified residuei119N6-methyllysine1 Publication1
Modified residuei127PhosphothreonineCombined sources1
Cross-linki129Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei165N6-acetyllysineCombined sources1
Modified residuei190PhosphoserineCombined sources1
Modified residuei193PhosphothreonineCombined sources1
Cross-linki197Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei243N6-acetyllysineBy similarity1
Modified residuei251N6-acetyllysineCombined sources1
Modified residuei271PhosphoserineCombined sources1
Modified residuei272Omega-N-methylarginineCombined sources1
Modified residuei278Omega-N-methylarginineCombined sources1
Modified residuei280Omega-N-methylarginineCombined sources1
Modified residuei282Omega-N-methylarginineBy similarity1
Modified residuei345Asymmetric dimethylarginine; alternateBy similarity1
Modified residuei345Dimethylated arginine; alternateCombined sources1
Modified residuei345Omega-N-methylarginine; alternateCombined sources1
Isoform 4 (identifier: Q14103-4)
Modified residuei263Omega-N-methylarginineCombined sources1
Modified residuei273N6-acetyllysineCombined sources1
Isoform 3 (identifier: Q14103-3)
Modified residuei282Omega-N-methylarginineCombined sources1
Modified residuei292N6-acetyllysineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Arg-345 is dimethylated, probably to asymmetric dimethylarginine.
Methylated by PRMT1, in an insulin-dependent manner. The PRMT1-mediated methylation regulates tyrosine phosphorylation (By similarity).By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q14103

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q14103

MaxQB - The MaxQuant DataBase

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MaxQBi
Q14103

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q14103

PeptideAtlas

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PeptideAtlasi
Q14103

PRoteomics IDEntifications database

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PRIDEi
Q14103

ProteomicsDB human proteome resource

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ProteomicsDBi
59811
59812 [Q14103-2]
59813 [Q14103-3]
59814 [Q14103-4]

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
Q14103-1 [Q14103-1]
Q14103-2 [Q14103-2]
Q14103-3 [Q14103-3]

2D gel databases

Two-dimensional polyacrylamide gel electrophoresis database from the Geneva University Hospital

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SWISS-2DPAGEi
Q14103

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q14103

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q14103

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q14103

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
Q14103

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000138668 Expressed in 238 organ(s), highest expression level in metanephros

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q14103 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q14103 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA004911

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Part of a complex associated with the FOS mCRD domain and consisting of PABPC1, PAIP1, CSDE1/UNR and SYNCRIP. Interacts with IGF2BP2. Interacts with GTPBP1. Interacts with EIF4G1; the interaction requires RNA. Interacts with EIF3B and RPS3.5 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
109425, 281 interactors

ComplexPortal: manually curated resource of macromolecular complexes

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ComplexPortali
CPX-1076 mCRD-poly(A)-bridging complex

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q14103

Database of interacting proteins

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DIPi
DIP-31163N

Protein interaction database and analysis system

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IntActi
Q14103, 151 interactors

Molecular INTeraction database

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MINTi
Q14103

STRING: functional protein association networks

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STRINGi
9606.ENSP00000313199

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1355
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1HD0NMR-A98-172[»]
1HD1NMR-A98-172[»]
1IQTNMR-A183-257[»]
1WTBNMR-A181-259[»]
1X0FNMR-A181-259[»]
2Z5NX-ray3.20B332-355[»]
5IM0X-ray1.70A71-175[»]
B96-175[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q14103

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q14103

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
Q14103

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini97 – 179RRM 1PROSITE-ProRule annotationAdd BLAST83
Domaini182 – 261RRM 2PROSITE-ProRule annotationAdd BLAST80

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi11 – 45Ala-richAdd BLAST35
Compositional biasi270 – 347Gly-richAdd BLAST78
Compositional biasi294 – 332Tyr-richAdd BLAST39

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0118 Eukaryota
COG0724 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000158010

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG002295

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q14103

KEGG Orthology (KO)

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KOi
K13044

Identification of Orthologs from Complete Genome Data

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OMAi
KKYHNIG

Database of Orthologous Groups

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OrthoDBi
1055256at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q14103

TreeFam database of animal gene trees

More...
TreeFami
TF314808

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.30.70.330, 2 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR012956 CARG-binding_factor_N
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08143 CBFNT, 1 hit
PF00076 RRM_1, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00360 RRM, 2 hits

Superfamily database of structural and functional annotation

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SUPFAMi
SSF54928 SSF54928, 2 hits

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS50102 RRM, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q14103-1) [UniParc]FASTAAdd to basket
Also known as: p45, Dx9

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSEEQFGGDG AAAAATAAVG GSAGEQEGAM VAATQGAAAA AGSGAGTGGG
60 70 80 90 100
TASGGTEGGS AESEGAKIDA SKNEEDEGHS NSSPRHSEAA TAQREEWKMF
110 120 130 140 150
IGGLSWDTTK KDLKDYFSKF GEVVDCTLKL DPITGRSRGF GFVLFKESES
160 170 180 190 200
VDKVMDQKEH KLNGKVIDPK RAKAMKTKEP VKKIFVGGLS PDTPEEKIRE
210 220 230 240 250
YFGGFGEVES IELPMDNKTN KRRGFCFITF KEEEPVKKIM EKKYHNVGLS
260 270 280 290 300
KCEIKVAMSK EQYQQQQQWG SRGGFAGRAR GRGGGPSQNW NQGYSNYWNQ
310 320 330 340 350
GYGNYGYNSQ GYGGYGGYDY TGYNNYYGYG DYSNQQSGYG KVSRRGGHQN

SYKPY
Length:355
Mass (Da):38,434
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD0B6EA177BEF789E
GO
Isoform 2 (identifier: Q14103-2) [UniParc]FASTAAdd to basket
Also known as: p42, Dx4

The sequence of this isoform differs from the canonical sequence as follows:
     79-97: Missing.

Show »
Length:336
Mass (Da):36,272
Checksum:iFEE18D61B7714B51
GO
Isoform 3 (identifier: Q14103-3) [UniParc]FASTAAdd to basket
Also known as: p40, Dx7

The sequence of this isoform differs from the canonical sequence as follows:
     285-334: GPSQNWNQGYSNYWNQGYGNYGYNSQGYGGYGGYDYTGYNNYYGYGDYSN → D

Show »
Length:306
Mass (Da):32,835
Checksum:iABCDD6ACF812F647
GO
Isoform 4 (identifier: Q14103-4) [UniParc]FASTAAdd to basket
Also known as: p37

The sequence of this isoform differs from the canonical sequence as follows:
     79-97: Missing.
     285-334: GPSQNWNQGYSNYWNQGYGNYGYNSQGYGGYGGYDYTGYNNYYGYGDYSN → D

Show »
Length:287
Mass (Da):30,672
Checksum:i98DF6E78EAF3BBC1
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y8G5H0Y8G5_HUMAN
Heterogeneous nuclear ribonucleopro...
HNRNPD
260Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RAF8D6RAF8_HUMAN
Heterogeneous nuclear ribonucleopro...
HNRNPD
221Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RF44D6RF44_HUMAN
Heterogeneous nuclear ribonucleopro...
HNRNPD
111Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RBQ9D6RBQ9_HUMAN
Heterogeneous nuclear ribonucleopro...
HNRNPD
155Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YA96H0YA96_HUMAN
Heterogeneous nuclear ribonucleopro...
HNRNPD
210Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RD83D6RD83_HUMAN
Heterogeneous nuclear ribonucleopro...
HNRNPD
92Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RBP9D6RBP9_HUMAN
Heterogeneous nuclear ribonucleopro...
HNRNPD
86Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA35781 differs from that shown. Contaminating sequence. Sequence of unknown origin in the N-terminal part.Curated
The sequence AAA35781 differs from that shown. Reason: Frameshift at positions 45, 59 and 355.Curated
The sequence CAA27544 differs from that shown. Several sequence conflicts.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti150S → R AA sequence (PubMed:8321232).Curated1
Sequence conflicti225F → L in AAA35781 (PubMed:1433497).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_00583479 – 97Missing in isoform 2 and isoform 4. 2 PublicationsAdd BLAST19
Alternative sequenceiVSP_005835285 – 334GPSQN…GDYSN → D in isoform 3 and isoform 4. 4 PublicationsAdd BLAST50

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
D55671 mRNA Translation: BAA09522.1
D55672 mRNA Translation: BAA09523.1
D55673 mRNA Translation: BAA09524.1
D55674 mRNA Translation: BAA09525.1
AF026126 Genomic DNA Translation: AAC23474.1
AF026126 Genomic DNA Translation: AAC23475.1
AF026126 Genomic DNA Translation: AAC23476.1
AK292707 mRNA Translation: BAF85396.1
AC124016 Genomic DNA Translation: AAY40913.1
CH471057 Genomic DNA Translation: EAX05874.1
BC002401 mRNA Translation: AAH02401.1
BC023977 mRNA Translation: AAH23977.1
BC026015 mRNA Translation: AAH26015.1
X03910 mRNA Translation: CAA27544.1 Sequence problems.
AF039575 mRNA Translation: AAB96683.1
M94630 mRNA Translation: AAA35781.1 Sequence problems.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS3590.1 [Q14103-3]
CCDS3591.1 [Q14103-2]
CCDS3592.1 [Q14103-1]

Protein sequence database of the Protein Information Resource

More...
PIRi
A24016
A44192
B48138

NCBI Reference Sequences

More...
RefSeqi
NP_001003810.1, NM_001003810.1 [Q14103-4]
NP_002129.2, NM_002138.3 [Q14103-3]
NP_112737.1, NM_031369.2 [Q14103-2]
NP_112738.1, NM_031370.2 [Q14103-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.480073

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000313899; ENSP00000313199; ENSG00000138668 [Q14103-1]
ENST00000352301; ENSP00000305860; ENSG00000138668 [Q14103-2]
ENST00000353341; ENSP00000313327; ENSG00000138668 [Q14103-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
3184

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:3184

UCSC genome browser

More...
UCSCi
uc003hmm.2 human [Q14103-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D55671 mRNA Translation: BAA09522.1
D55672 mRNA Translation: BAA09523.1
D55673 mRNA Translation: BAA09524.1
D55674 mRNA Translation: BAA09525.1
AF026126 Genomic DNA Translation: AAC23474.1
AF026126 Genomic DNA Translation: AAC23475.1
AF026126 Genomic DNA Translation: AAC23476.1
AK292707 mRNA Translation: BAF85396.1
AC124016 Genomic DNA Translation: AAY40913.1
CH471057 Genomic DNA Translation: EAX05874.1
BC002401 mRNA Translation: AAH02401.1
BC023977 mRNA Translation: AAH23977.1
BC026015 mRNA Translation: AAH26015.1
X03910 mRNA Translation: CAA27544.1 Sequence problems.
AF039575 mRNA Translation: AAB96683.1
M94630 mRNA Translation: AAA35781.1 Sequence problems.
CCDSiCCDS3590.1 [Q14103-3]
CCDS3591.1 [Q14103-2]
CCDS3592.1 [Q14103-1]
PIRiA24016
A44192
B48138
RefSeqiNP_001003810.1, NM_001003810.1 [Q14103-4]
NP_002129.2, NM_002138.3 [Q14103-3]
NP_112737.1, NM_031369.2 [Q14103-2]
NP_112738.1, NM_031370.2 [Q14103-1]
UniGeneiHs.480073

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1HD0NMR-A98-172[»]
1HD1NMR-A98-172[»]
1IQTNMR-A183-257[»]
1WTBNMR-A181-259[»]
1X0FNMR-A181-259[»]
2Z5NX-ray3.20B332-355[»]
5IM0X-ray1.70A71-175[»]
B96-175[»]
ProteinModelPortaliQ14103
SMRiQ14103
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109425, 281 interactors
ComplexPortaliCPX-1076 mCRD-poly(A)-bridging complex
CORUMiQ14103
DIPiDIP-31163N
IntActiQ14103, 151 interactors
MINTiQ14103
STRINGi9606.ENSP00000313199

Protein family/group databases

MoonDBiQ14103 Predicted

PTM databases

iPTMnetiQ14103
PhosphoSitePlusiQ14103
SwissPalmiQ14103

Polymorphism and mutation databases

BioMutaiHNRNPD
DMDMi13124489

2D gel databases

SWISS-2DPAGEiQ14103

Proteomic databases

EPDiQ14103
jPOSTiQ14103
MaxQBiQ14103
PaxDbiQ14103
PeptideAtlasiQ14103
PRIDEiQ14103
ProteomicsDBi59811
59812 [Q14103-2]
59813 [Q14103-3]
59814 [Q14103-4]
TopDownProteomicsiQ14103-1 [Q14103-1]
Q14103-2 [Q14103-2]
Q14103-3 [Q14103-3]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
3184
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000313899; ENSP00000313199; ENSG00000138668 [Q14103-1]
ENST00000352301; ENSP00000305860; ENSG00000138668 [Q14103-2]
ENST00000353341; ENSP00000313327; ENSG00000138668 [Q14103-3]
GeneIDi3184
KEGGihsa:3184
UCSCiuc003hmm.2 human [Q14103-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3184
DisGeNETi3184
EuPathDBiHostDB:ENSG00000138668.18

GeneCards: human genes, protein and diseases

More...
GeneCardsi
HNRNPD
HGNCiHGNC:5036 HNRNPD
HPAiHPA004911
MIMi601324 gene
neXtProtiNX_Q14103
OpenTargetsiENSG00000138668
PharmGKBiPA29361

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0118 Eukaryota
COG0724 LUCA
GeneTreeiENSGT00940000158010
HOVERGENiHBG002295
InParanoidiQ14103
KOiK13044
OMAiKKYHNIG
OrthoDBi1055256at2759
PhylomeDBiQ14103
TreeFamiTF314808

Enzyme and pathway databases

ReactomeiR-HSA-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA
R-HSA-72163 mRNA Splicing - Major Pathway
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA
SIGNORiQ14103

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
HNRNPD human
EvolutionaryTraceiQ14103

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
HNRPD

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
3184
PMAP-CutDBiQ14103

Protein Ontology

More...
PROi
PR:Q14103

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000138668 Expressed in 238 organ(s), highest expression level in metanephros
ExpressionAtlasiQ14103 baseline and differential
GenevisibleiQ14103 HS

Family and domain databases

Gene3Di3.30.70.330, 2 hits
InterProiView protein in InterPro
IPR012956 CARG-binding_factor_N
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
PfamiView protein in Pfam
PF08143 CBFNT, 1 hit
PF00076 RRM_1, 2 hits
SMARTiView protein in SMART
SM00360 RRM, 2 hits
SUPFAMiSSF54928 SSF54928, 2 hits
PROSITEiView protein in PROSITE
PS50102 RRM, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHNRPD_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q14103
Secondary accession number(s): A8K9J2
, P07029, Q01858, Q14100, Q14101, Q14102, Q4W5A1, Q9UCE8, Q9UCE9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: November 1, 1996
Last modified: January 16, 2019
This is version 215 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
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