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Entry version 136 (08 May 2019)
Sequence version 1 (01 Nov 1997)
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Protein

Cylicin-2

Gene

CYLC2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Possible architectural role during spermatogenesis. May be involved in spermatid differentiation.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • structural constituent of cytoskeleton Source: ProtInc

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation, Spermatogenesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cylicin-2
Alternative name(s):
Cylicin II
Multiple-band polypeptide II
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CYLC2
Synonyms:CYL2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:2583 CYLC2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
604035 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q14093

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
1539

Open Targets

More...
OpenTargetsi
ENSG00000155833

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA27083

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CYLC2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
2498278

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000797551 – 348Cylicin-2Add BLAST348

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q14093

PeptideAtlas

More...
PeptideAtlasi
Q14093

PRoteomics IDEntifications database

More...
PRIDEi
Q14093

ProteomicsDB human proteome resource

More...
ProteomicsDBi
59808

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q14093

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q14093

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Testis.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000155833 Expressed in 66 organ(s), highest expression level in testis

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q14093 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q14093 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
107919, 2 interactors

Protein interaction database and analysis system

More...
IntActi
Q14093, 15 interactors

Molecular INTeraction database

More...
MINTi
Q14093

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000420256

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati157 – 1841Add BLAST28
Repeati185 – 2122Add BLAST28
Repeati213 – 2403Add BLAST28

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni25 – 34731 X 3 AA repeats of K-K-XAdd BLAST323
Regioni157 – 2403 X approximate tandem repeatsAdd BLAST84

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410J18N Eukaryota
ENOG4111C35 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00730000111075

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000112131

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q14093

Identification of Orthologs from Complete Genome Data

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OMAi
PLWMYRS

Database of Orthologous Groups

More...
OrthoDBi
1524900at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q14093

TreeFam database of animal gene trees

More...
TreeFami
TF337809

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026189 CYLC
IPR029354 Cylicin_N

The PANTHER Classification System

More...
PANTHERi
PTHR16742 PTHR16742, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15241 Cylicin_N, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q14093-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSLPRFQRVN FGPYDNYIPV SELSKKSWNQ QHFALLFPKP QRPGTKRRSK
60 70 80 90 100
PSQIRDNTVS IIDEEQLRGD RRQPLWMYRS LMRISERPSV YLAARRQPLK
110 120 130 140 150
PTRTVEVDSK AAEIGKKGED KTTQKDTTDS ESELKQGKKD SKKGKDIEKG
160 170 180 190 200
KEEKLDAKKD SKKGKKDAEK GKDSATESED EKGGAKKDNK KDKKDSNKGK
210 220 230 240 250
DSATESEGEK GGTEKDSKKG KKDSKKGKDS AIELQAVKAD EKKDEDGKKD
260 270 280 290 300
ANKGDESKDA KKDAKEIKKG KKDKKKPSST DSDSKDDVKK ESKKDATKDA
310 320 330 340
KKVAKKDTEK ESADSKKDAK KNAKKDAKKD AKKNAKKDEK KDAKKKGK
Length:348
Mass (Da):39,079
Last modified:November 1, 1997 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD86766599C1809E7
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_050938146D → Y. Corresponds to variant dbSNP:rs13293961Ensembl.1
Natural variantiVAR_050939184G → D. Corresponds to variant dbSNP:rs10990424Ensembl.1
Natural variantiVAR_020100190K → E. Corresponds to variant dbSNP:rs2298050Ensembl.1
Natural variantiVAR_020101208G → D. Corresponds to variant dbSNP:rs2298051Ensembl.1
Natural variantiVAR_020102319A → E. Corresponds to variant dbSNP:rs3763636Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Z46788 mRNA Translation: CAA86752.1
AK313349 mRNA Translation: BAG36151.1
AL449304 Genomic DNA No translation available.
BC114547 mRNA Translation: AAI14548.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS35085.1

Protein sequence database of the Protein Information Resource

More...
PIRi
I37271

NCBI Reference Sequences

More...
RefSeqi
NP_001331.1, NM_001340.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000374798; ENSP00000420256; ENSG00000155833
ENST00000487798; ENSP00000417674; ENSG00000155833
ENST00000612124; ENSP00000478399; ENSG00000155833

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
1539

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:1539

UCSC genome browser

More...
UCSCi
uc004bbs.2 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46788 mRNA Translation: CAA86752.1
AK313349 mRNA Translation: BAG36151.1
AL449304 Genomic DNA No translation available.
BC114547 mRNA Translation: AAI14548.1
CCDSiCCDS35085.1
PIRiI37271
RefSeqiNP_001331.1, NM_001340.4

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi107919, 2 interactors
IntActiQ14093, 15 interactors
MINTiQ14093
STRINGi9606.ENSP00000420256

PTM databases

iPTMnetiQ14093
PhosphoSitePlusiQ14093

Polymorphism and mutation databases

BioMutaiCYLC2
DMDMi2498278

Proteomic databases

PaxDbiQ14093
PeptideAtlasiQ14093
PRIDEiQ14093
ProteomicsDBi59808

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000374798; ENSP00000420256; ENSG00000155833
ENST00000487798; ENSP00000417674; ENSG00000155833
ENST00000612124; ENSP00000478399; ENSG00000155833
GeneIDi1539
KEGGihsa:1539
UCSCiuc004bbs.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1539
DisGeNETi1539

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CYLC2
HGNCiHGNC:2583 CYLC2
MIMi604035 gene
neXtProtiNX_Q14093
OpenTargetsiENSG00000155833
PharmGKBiPA27083

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410J18N Eukaryota
ENOG4111C35 LUCA
GeneTreeiENSGT00730000111075
HOGENOMiHOG000112131
InParanoidiQ14093
OMAiPLWMYRS
OrthoDBi1524900at2759
PhylomeDBiQ14093
TreeFamiTF337809

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CYLC2 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
1539

Protein Ontology

More...
PROi
PR:Q14093

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000155833 Expressed in 66 organ(s), highest expression level in testis
ExpressionAtlasiQ14093 baseline and differential
GenevisibleiQ14093 HS

Family and domain databases

InterProiView protein in InterPro
IPR026189 CYLC
IPR029354 Cylicin_N
PANTHERiPTHR16742 PTHR16742, 2 hits
PfamiView protein in Pfam
PF15241 Cylicin_N, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCYLC2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q14093
Secondary accession number(s): B2R8F4, Q5VVJ9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: May 8, 2019
This is version 136 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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