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Protein

Ras-related protein Rab-33A

Gene

RAB33A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi43 – 50GTPBy similarity8
Nucleotide bindingi91 – 95GTPBy similarity5
Nucleotide bindingi151 – 154GTPBy similarity4

GO - Molecular functioni

GO - Biological processi

  • antigen processing and presentation Source: UniProtKB
  • regulation of autophagosome assembly Source: GO_Central

Keywordsi

LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-8854214 TBC/RABGAPs
R-HSA-8873719 RAB geranylgeranylation

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-33A
Alternative name(s):
Small GTP-binding protein S10
Gene namesi
Name:RAB33A
Synonyms:RABS10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000134594.4
HGNCiHGNC:9773 RAB33A
MIMi300333 gene
neXtProtiNX_Q14088

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi9363
OpenTargetsiENSG00000134594
PharmGKBiPA34124

Polymorphism and mutation databases

BioMutaiRAB33A
DMDMi2500071

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001212371 – 237Ras-related protein Rab-33AAdd BLAST237

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi235S-geranylgeranyl cysteineBy similarity1
Modified residuei237Cysteine methyl esterBy similarity1
Lipidationi237S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

EPDiQ14088
MaxQBiQ14088
PaxDbiQ14088
PeptideAtlasiQ14088
PRIDEiQ14088
ProteomicsDBi59807

PTM databases

iPTMnetiQ14088
PhosphoSitePlusiQ14088

Expressioni

Tissue specificityi

Expressed only in lymphoid cell lines.

Gene expression databases

BgeeiENSG00000134594 Expressed in 140 organ(s), highest expression level in C1 segment of cervical spinal cord
CleanExiHS_RAB33A
GenevisibleiQ14088 HS

Organism-specific databases

HPAiHPA059737

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi114764, 17 interactors
IntActiQ14088, 15 interactors
STRINGi9606.ENSP00000257017

Structurei

3D structure databases

ProteinModelPortaliQ14088
SMRiQ14088
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0084 Eukaryota
ENOG410XQN5 LUCA
GeneTreeiENSGT00900000140786
HOGENOMiHOG000233968
HOVERGENiHBG009351
InParanoidiQ14088
KOiK07919
OMAiWIEECNG
OrthoDBiEOG091G0FVM
PhylomeDBiQ14088
TreeFamiTF300097

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51419 RAB, 1 hit

Sequencei

Sequence statusi: Complete.

Q14088-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAQPILGHGS LQPASAAGLA SLELDSSLDQ YVQIRIFKII VIGDSNVGKT
60 70 80 90 100
CLTFRFCGGT FPDKTEATIG VDFREKTVEI EGEKIKVQVW DTAGQERFRK
110 120 130 140 150
SMVEHYYRNV HAVVFVYDVT KMTSFTNLKM WIQECNGHAV PPLVPKVLVG
160 170 180 190 200
NKCDLREQIQ VPSNLALKFA DAHNMLLFET SAKDPKESQN VESIFMCLAC
210 220 230
RLKAQKSLLY RDAERQQGKV QKLEFPQEAN SKTSCPC
Length:237
Mass (Da):26,593
Last modified:May 1, 1997 - v2
Checksum:i2EE23B8237225F4A
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_006849102M → T. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D14889 mRNA Translation: BAA03606.1
AF498959 mRNA Translation: AAM21107.1
BT007038 mRNA Translation: AAP35687.1
AL139234 Genomic DNA No translation available.
BC001157 mRNA Translation: AAH01157.1
BC009996 mRNA Translation: AAH09996.1
CCDSiCCDS14621.1
PIRiS35058
RefSeqiNP_004785.1, NM_004794.2
UniGeneiHs.654356

Genome annotation databases

EnsembliENST00000257017; ENSP00000257017; ENSG00000134594
GeneIDi9363
KEGGihsa:9363
UCSCiuc004evl.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D14889 mRNA Translation: BAA03606.1
AF498959 mRNA Translation: AAM21107.1
BT007038 mRNA Translation: AAP35687.1
AL139234 Genomic DNA No translation available.
BC001157 mRNA Translation: AAH01157.1
BC009996 mRNA Translation: AAH09996.1
CCDSiCCDS14621.1
PIRiS35058
RefSeqiNP_004785.1, NM_004794.2
UniGeneiHs.654356

3D structure databases

ProteinModelPortaliQ14088
SMRiQ14088
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114764, 17 interactors
IntActiQ14088, 15 interactors
STRINGi9606.ENSP00000257017

PTM databases

iPTMnetiQ14088
PhosphoSitePlusiQ14088

Polymorphism and mutation databases

BioMutaiRAB33A
DMDMi2500071

Proteomic databases

EPDiQ14088
MaxQBiQ14088
PaxDbiQ14088
PeptideAtlasiQ14088
PRIDEiQ14088
ProteomicsDBi59807

Protocols and materials databases

DNASUi9363
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000257017; ENSP00000257017; ENSG00000134594
GeneIDi9363
KEGGihsa:9363
UCSCiuc004evl.4 human

Organism-specific databases

CTDi9363
DisGeNETi9363
EuPathDBiHostDB:ENSG00000134594.4
GeneCardsiRAB33A
HGNCiHGNC:9773 RAB33A
HPAiHPA059737
MIMi300333 gene
neXtProtiNX_Q14088
OpenTargetsiENSG00000134594
PharmGKBiPA34124
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0084 Eukaryota
ENOG410XQN5 LUCA
GeneTreeiENSGT00900000140786
HOGENOMiHOG000233968
HOVERGENiHBG009351
InParanoidiQ14088
KOiK07919
OMAiWIEECNG
OrthoDBiEOG091G0FVM
PhylomeDBiQ14088
TreeFamiTF300097

Enzyme and pathway databases

ReactomeiR-HSA-8854214 TBC/RABGAPs
R-HSA-8873719 RAB geranylgeranylation

Miscellaneous databases

GeneWikiiRAB33A
GenomeRNAii9363
PROiPR:Q14088
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000134594 Expressed in 140 organ(s), highest expression level in C1 segment of cervical spinal cord
CleanExiHS_RAB33A
GenevisibleiQ14088 HS

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51419 RAB, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRB33A_HUMAN
AccessioniPrimary (citable) accession number: Q14088
Secondary accession number(s): Q5JUZ6, Q92465
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 1, 1997
Last modified: September 12, 2018
This is version 168 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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