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Protein

Cyclic nucleotide-gated cation channel beta-1

Gene

CNGB1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Subunit of cyclic nucleotide-gated (CNG) channels, nonselective cation channels, which play important roles in both visual and olfactory signal transduction. When associated with CNGA1, it is involved in the regulation of ion flow into the rod photoreceptor outer segment (ROS), in response to light-induced alteration of the levels of intracellular cGMP.
Isoform GARP2 is a high affinity rod photoreceptor phosphodiesterase (PDE6)-binding protein that modulates its catalytic properties: it is a regulator of spontaneous activation of rod PDE6, thereby serving to lower rod photoreceptor 'dark noise' and allowing these sensory cells to operate at the single photon detection limit.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei1030cAMPSequence analysis1
Binding sitei1042cAMPSequence analysis1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi970 – 1109cAMPBy similarityAdd BLAST140

GO - Molecular functioni

  • cAMP binding Source: UniProtKB-KW
  • cGMP binding Source: UniProtKB
  • intracellular cAMP-activated cation channel activity Source: GO_Central
  • intracellular cGMP-activated cation channel activity Source: UniProtKB
  • ligand-gated ion channel activity Source: ProtInc

GO - Biological processi

Keywordsi

Molecular functionIon channel, Ligand-gated ion channel
Biological processIon transport, Olfaction, Sensory transduction, Transport, Vision
LigandcAMP, cAMP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-2485179 Activation of the phototransduction cascade
R-HSA-2514859 Inactivation, recovery and regulation of the phototransduction cascade
R-HSA-5620916 VxPx cargo-targeting to cilium

Protein family/group databases

TCDBi1.A.1.5.3 the voltage-gated ion channel (vic) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclic nucleotide-gated cation channel beta-1
Alternative name(s):
Cyclic nucleotide-gated cation channel 4
Short name:
CNG channel 4
Short name:
CNG-4
Short name:
CNG4
Cyclic nucleotide-gated cation channel gamma
Cyclic nucleotide-gated cation channel modulatory subunit
Cyclic nucleotide-gated channel beta-1
Short name:
CNG channel beta-1
Glutamic acid-rich protein
Short name:
GARP
Gene namesi
Name:CNGB1
Synonyms:CNCG2, CNCG3L, CNCG4, RCNC2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000070729.13
HGNCiHGNC:2151 CNGB1
MIMi600724 gene
neXtProtiNX_Q14028

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini343 – 656CytoplasmicSequence analysisAdd BLAST314
Transmembranei657 – 675Helical; Name=H1Sequence analysisAdd BLAST19
Topological domaini676 – 689ExtracellularSequence analysisAdd BLAST14
Transmembranei690 – 708Helical; Name=H2Sequence analysisAdd BLAST19
Topological domaini709 – 733CytoplasmicSequence analysisAdd BLAST25
Transmembranei734 – 753Helical; Name=H3Sequence analysisAdd BLAST20
Topological domaini754 – 790ExtracellularSequence analysisAdd BLAST37
Transmembranei791 – 813Helical; Name=H4Sequence analysisAdd BLAST23
Topological domaini814 – 857CytoplasmicSequence analysisAdd BLAST44
Transmembranei858 – 877Helical; Name=H5Sequence analysisAdd BLAST20
Topological domaini878 – 961ExtracellularSequence analysisAdd BLAST84
Transmembranei962 – 982Helical; Name=H6Sequence analysisAdd BLAST21
Topological domaini983 – 1251CytoplasmicSequence analysisAdd BLAST269

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Involvement in diseasei

Retinitis pigmentosa 45 (RP45)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.
See also OMIM:613767
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_060491993G → V in RP45. 1 PublicationCorresponds to variant dbSNP:rs121918532EnsemblClinVar.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi568L → E: Loss of calcium/calmodulin modulation. 1 Publication1

Keywords - Diseasei

Disease mutation, Retinitis pigmentosa

Organism-specific databases

DisGeNETi1258
GeneReviewsiCNGB1
MalaCardsiCNGB1
MIMi613767 phenotype
OpenTargetsiENSG00000070729
Orphaneti791 Retinitis pigmentosa
PharmGKBiPA26662

Polymorphism and mutation databases

BioMutaiCNGB1
DMDMi257051004

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002193231 – 1251Cyclic nucleotide-gated cation channel beta-1Add BLAST1251

Proteomic databases

EPDiQ14028
PaxDbiQ14028
PeptideAtlasiQ14028
PRIDEiQ14028
ProteomicsDBi59797
59798 [Q14028-2]
59799 [Q14028-3]

PTM databases

iPTMnetiQ14028
PhosphoSitePlusiQ14028

Expressioni

Gene expression databases

BgeeiENSG00000070729 Expressed in 137 organ(s), highest expression level in myocardium
CleanExiHS_CNGB1
ExpressionAtlasiQ14028 baseline and differential
GenevisibleiQ14028 HS

Organism-specific databases

HPAiHPA039159
HPA060355

Interactioni

Subunit structurei

Tetramer formed of three CNGA1 and one CNGB1 modulatory subunits.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
GRB14Q5ICW42EBI-7959609,EBI-7639273From Bos taurus.

Protein-protein interaction databases

BioGridi107658, 2 interactors
IntActiQ14028, 2 interactors
MINTiQ14028
STRINGi9606.ENSP00000251102

Structurei

3D structure databases

ProteinModelPortaliQ14028
SMRiQ14028
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi568 – 578IQ-likeAdd BLAST11

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi23 – 63Glu-richAdd BLAST41
Compositional biasi171 – 252Pro-richAdd BLAST82
Compositional biasi351 – 371Poly-GluAdd BLAST21

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0499 Eukaryota
ENOG410ZJ5U LUCA
GeneTreeiENSGT00900000140801
HOGENOMiHOG000231425
HOVERGENiHBG051038
InParanoidiQ14028
KOiK04952
OMAiTDKKDMR
OrthoDBiEOG091G03EW
PhylomeDBiQ14028
TreeFamiTF318250

Family and domain databases

CDDicd00038 CAP_ED, 1 hit
Gene3Di2.60.120.10, 1 hit
InterProiView protein in InterPro
IPR032944 CNGB1
IPR018490 cNMP-bd-like
IPR018488 cNMP-bd_CS
IPR000595 cNMP-bd_dom
IPR014710 RmlC-like_jellyroll
PANTHERiPTHR10217:SF386 PTHR10217:SF386, 1 hit
PfamiView protein in Pfam
PF00027 cNMP_binding, 1 hit
SMARTiView protein in SMART
SM00100 cNMP, 1 hit
SUPFAMiSSF51206 SSF51206, 1 hit
PROSITEiView protein in PROSITE
PS00888 CNMP_BINDING_1, 1 hit
PS00889 CNMP_BINDING_2, 1 hit
PS50042 CNMP_BINDING_3, 1 hit

Sequences (4+)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket
Note: There is no evidence for an ortholog to bovine GARP1 in the human genome.

This entry has 4 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform RCNC2B (identifier: Q14028-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLGWVQRVLP QPPGTPRKTK MQEEEEVEPE PEMEAEVEPE PNPEEAETES
60 70 80 90 100
ESMPPEESFK EEEVAVADPS PQETKEAALT STISLRAQGA EISEMNSPSR
110 120 130 140 150
RVLTWLMKGV EKVIPQPVHS ITEDPAQILG HGSTGDTGCT DEPNEALEAQ
160 170 180 190 200
DTRPGLRLLL WLEQNLERVL PQPPKSSEVW RDEPAVATGA ASDPAPPGRP
210 220 230 240 250
QEMGPKLQAR ETPSLPTPIP LQPKEEPKEA PAPEPQPGSQ AQTSSLPPTR
260 270 280 290 300
DPARLVAWVL HRLEMALPQP VLHGKIGEQE PDSPGICDVQ TISILPGGQV
310 320 330 340 350
EPDLVLEEVE PPWEDAHQDV STSPQGTEVV PAYEEENKAV EKMPRELSRI
360 370 380 390 400
EEEKEDEEEE EEEEEEEEEE EVTEVLLDSC VVSQVGVGQS EEDGTRPQST
410 420 430 440 450
SDQKLWEEVG EEAKKEAEEK AKEEAEEVAE EEAEKEPQDW AETKEEPEAE
460 470 480 490 500
AEAASSGVPA TKQHPEVQVE DTDADSCPLM AEENPPSTVL PPPSPAKSDT
510 520 530 540 550
LIVPSSASGT HRKKLPSEDD EAEELKALSP AESPVVAWSD PTTPKDTDGQ
560 570 580 590 600
DRAASTASTN SAIINDRLQE LVKLFKERTE KVKEKLIDPD VTSDEESPKP
610 620 630 640 650
SPAKKAPEPA PDTKPAEAEP VEEEHYCDML CCKFKHRPWK KYQFPQSIDP
660 670 680 690 700
LTNLMYVLWL FFVVMAWNWN CWLIPVRWAF PYQTPDNIHH WLLMDYLCDL
710 720 730 740 750
IYFLDITVFQ TRLQFVRGGD IITDKKDMRN NYLKSRRFKM DLLSLLPLDF
760 770 780 790 800
LYLKVGVNPL LRLPRCLKYM AFFEFNSRLE SILSKAYVYR VIRTTAYLLY
810 820 830 840 850
SLHLNSCLYY WASAYQGLGS THWVYDGVGN SYIRCYYFAV KTLITIGGLP
860 870 880 890 900
DPKTLFEIVF QLLNYFTGVF AFSVMIGQMR DVVGAATAGQ TYYRSCMDST
910 920 930 940 950
VKYMNFYKIP KSVQNRVKTW YEYTWHSQGM LDESELMVQL PDKMRLDLAI
960 970 980 990 1000
DVNYNIVSKV ALFQGCDRQM IFDMLKRLRS VVYLPNDYVC KKGEIGREMY
1010 1020 1030 1040 1050
IIQAGQVQVL GGPDGKSVLV TLKAGSVFGE ISLLAVGGGN RRTANVVAHG
1060 1070 1080 1090 1100
FTNLFILDKK DLNEILVHYP ESQKLLRKKA RRMLRSNNKP KEEKSVLILP
1110 1120 1130 1140 1150
PRAGTPKLFN AALAMTGKMG GKGAKGGKLA HLRARLKELA ALEAAAKQQE
1160 1170 1180 1190 1200
LVEQAKSSQD VKGEEGSAAP DQHTHPKEAA TDPPAPRTPP EPPGSPPSSP
1210 1220 1230 1240 1250
PPASLGRPEG EEEGPAEPEE HSVRICMSPG PEPGEQILSV KMPEEREEKA

E
Length:1,251
Mass (Da):139,678
Last modified:September 1, 2009 - v2
Checksum:i7A45CB399EB2B20C
GO
Isoform RCNC2A (identifier: Q14028-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-628: Missing.

Show »
Length:623
Mass (Da):70,901
Checksum:i19FD335A37A9BD8A
GO
Isoform GARP2 (identifier: Q14028-3) [UniParc]FASTAAdd to basket
Also known as: GARP

The sequence of this isoform differs from the canonical sequence as follows:
     292-299: ISILPGGQ → RVMGAGGL
     300-1251: Missing.

Note: In the rod cells, the CNGB1 locus encodes the cyclic nucleotide-gated cation channel beta-1 subunit and several glutamic-acid-rich proteins (GARPs).
Show »
Length:299
Mass (Da):32,531
Checksum:i1B07296CA8ECB655
GO
Isoform 4 (identifier: Q14028-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     189-194: Missing.

Show »
Length:1,245
Mass (Da):139,179
Checksum:iE99F22376984493D
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BQW3H3BQW3_HUMAN
Cyclic nucleotide-gated cation chan...
CNGB1
126Annotation score:
A0A2R8Y6Y0A0A2R8Y6Y0_HUMAN
Cyclic nucleotide-gated cation chan...
CNGB1
112Annotation score:
H3BQC3H3BQC3_HUMAN
Cyclic nucleotide-gated cation chan...
CNGB1
214Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti128I → V in AC010543 (PubMed:15616553).Curated1
Sequence conflicti1148 – 1149QQ → HE in AAB63387 (PubMed:7590744).Curated2
Sequence conflicti1148 – 1149QQ → HE in AAA65619 (PubMed:7682292).Curated2
Sequence conflicti1148 – 1149QQ → HE in AAA65620 (PubMed:7682292).Curated2
Sequence conflicti1207 – 1208RP → SC in AAB63387 (PubMed:7590744).Curated2
Sequence conflicti1207 – 1208RP → SC in AAA65619 (PubMed:7682292).Curated2
Sequence conflicti1207 – 1208RP → SC in AAA65620 (PubMed:7682292).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_058691100R → H3 PublicationsCorresponds to variant dbSNP:rs13336595EnsemblClinVar.1
Natural variantiVAR_059225479L → I. Corresponds to variant dbSNP:rs2303783EnsemblClinVar.1
Natural variantiVAR_059226535V → A. Corresponds to variant dbSNP:rs12927214EnsemblClinVar.1
Natural variantiVAR_059227731N → K. Corresponds to variant dbSNP:rs376270Ensembl.1
Natural variantiVAR_059228745L → I. Corresponds to variant dbSNP:rs10459809EnsemblClinVar.1
Natural variantiVAR_059229911K → R. Corresponds to variant dbSNP:rs2303785EnsemblClinVar.1
Natural variantiVAR_059230961A → S. Corresponds to variant dbSNP:rs16942445EnsemblClinVar.1
Natural variantiVAR_060491993G → V in RP45. 1 PublicationCorresponds to variant dbSNP:rs121918532EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0011101 – 628Missing in isoform RCNC2A. CuratedAdd BLAST628
Alternative sequenceiVSP_053421189 – 194Missing in isoform 4. Curated6
Alternative sequenceiVSP_037921292 – 299ISILPGGQ → RVMGAGGL in isoform GARP2. 1 Publication8
Alternative sequenceiVSP_037922300 – 1251Missing in isoform GARP2. 1 PublicationAdd BLAST952

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L15296 Genomic DNA Translation: AAA65620.1
L15297 Genomic DNA Translation: AAA65619.1
U18945 mRNA Translation: AAA91633.1
U58837 mRNA Translation: AAB63387.1
AF042498 mRNA Translation: AAC04830.1
AC010543 Genomic DNA No translation available.
CH471092 Genomic DNA Translation: EAW82957.1
CCDSiCCDS42169.1 [Q14028-1]
CCDS45495.1 [Q14028-3]
CCDS67042.1 [Q14028-4]
PIRiA57652
S32538
S69275
RefSeqiNP_001129111.1, NM_001135639.1 [Q14028-3]
NP_001273059.1, NM_001286130.1 [Q14028-4]
NP_001288.3, NM_001297.4 [Q14028-1]
UniGeneiHs.147062

Genome annotation databases

EnsembliENST00000251102; ENSP00000251102; ENSG00000070729 [Q14028-1]
ENST00000311183; ENSP00000311670; ENSG00000070729 [Q14028-3]
ENST00000564448; ENSP00000454633; ENSG00000070729 [Q14028-4]
GeneIDi1258
KEGGihsa:1258
UCSCiuc002emt.3 human [Q14028-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L15296 Genomic DNA Translation: AAA65620.1
L15297 Genomic DNA Translation: AAA65619.1
U18945 mRNA Translation: AAA91633.1
U58837 mRNA Translation: AAB63387.1
AF042498 mRNA Translation: AAC04830.1
AC010543 Genomic DNA No translation available.
CH471092 Genomic DNA Translation: EAW82957.1
CCDSiCCDS42169.1 [Q14028-1]
CCDS45495.1 [Q14028-3]
CCDS67042.1 [Q14028-4]
PIRiA57652
S32538
S69275
RefSeqiNP_001129111.1, NM_001135639.1 [Q14028-3]
NP_001273059.1, NM_001286130.1 [Q14028-4]
NP_001288.3, NM_001297.4 [Q14028-1]
UniGeneiHs.147062

3D structure databases

ProteinModelPortaliQ14028
SMRiQ14028
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107658, 2 interactors
IntActiQ14028, 2 interactors
MINTiQ14028
STRINGi9606.ENSP00000251102

Protein family/group databases

TCDBi1.A.1.5.3 the voltage-gated ion channel (vic) superfamily

PTM databases

iPTMnetiQ14028
PhosphoSitePlusiQ14028

Polymorphism and mutation databases

BioMutaiCNGB1
DMDMi257051004

Proteomic databases

EPDiQ14028
PaxDbiQ14028
PeptideAtlasiQ14028
PRIDEiQ14028
ProteomicsDBi59797
59798 [Q14028-2]
59799 [Q14028-3]

Protocols and materials databases

DNASUi1258
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000251102; ENSP00000251102; ENSG00000070729 [Q14028-1]
ENST00000311183; ENSP00000311670; ENSG00000070729 [Q14028-3]
ENST00000564448; ENSP00000454633; ENSG00000070729 [Q14028-4]
GeneIDi1258
KEGGihsa:1258
UCSCiuc002emt.3 human [Q14028-1]

Organism-specific databases

CTDi1258
DisGeNETi1258
EuPathDBiHostDB:ENSG00000070729.13
GeneCardsiCNGB1
GeneReviewsiCNGB1
H-InvDBiHIX0038536
HGNCiHGNC:2151 CNGB1
HPAiHPA039159
HPA060355
MalaCardsiCNGB1
MIMi600724 gene
613767 phenotype
neXtProtiNX_Q14028
OpenTargetsiENSG00000070729
Orphaneti791 Retinitis pigmentosa
PharmGKBiPA26662
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0499 Eukaryota
ENOG410ZJ5U LUCA
GeneTreeiENSGT00900000140801
HOGENOMiHOG000231425
HOVERGENiHBG051038
InParanoidiQ14028
KOiK04952
OMAiTDKKDMR
OrthoDBiEOG091G03EW
PhylomeDBiQ14028
TreeFamiTF318250

Enzyme and pathway databases

ReactomeiR-HSA-2485179 Activation of the phototransduction cascade
R-HSA-2514859 Inactivation, recovery and regulation of the phototransduction cascade
R-HSA-5620916 VxPx cargo-targeting to cilium

Miscellaneous databases

ChiTaRSiCNGB1 human
GeneWikiiCNGB1
GenomeRNAii1258
PROiPR:Q14028
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000070729 Expressed in 137 organ(s), highest expression level in myocardium
CleanExiHS_CNGB1
ExpressionAtlasiQ14028 baseline and differential
GenevisibleiQ14028 HS

Family and domain databases

CDDicd00038 CAP_ED, 1 hit
Gene3Di2.60.120.10, 1 hit
InterProiView protein in InterPro
IPR032944 CNGB1
IPR018490 cNMP-bd-like
IPR018488 cNMP-bd_CS
IPR000595 cNMP-bd_dom
IPR014710 RmlC-like_jellyroll
PANTHERiPTHR10217:SF386 PTHR10217:SF386, 1 hit
PfamiView protein in Pfam
PF00027 cNMP_binding, 1 hit
SMARTiView protein in SMART
SM00100 cNMP, 1 hit
SUPFAMiSSF51206 SSF51206, 1 hit
PROSITEiView protein in PROSITE
PS00888 CNMP_BINDING_1, 1 hit
PS00889 CNMP_BINDING_2, 1 hit
PS50042 CNMP_BINDING_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCNGB1_HUMAN
AccessioniPrimary (citable) accession number: Q14028
Secondary accession number(s): H3BN09
, O43636, Q13059, Q14029, Q9UMG2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: September 1, 2009
Last modified: November 7, 2018
This is version 164 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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