UniProtKB - Q14008 (CKAP5_HUMAN)
Cytoskeleton-associated protein 5
CKAP5
Functioni
GO - Molecular functioni
- cadherin binding Source: BHF-UCL
- microtubule binding Source: MGI
- microtubule plus end polymerase Source: GO_Central
- ribonucleoprotein complex binding Source: MGI
GO - Biological processi
- cell division Source: UniProtKB-KW
- centrosome cycle Source: HGNC-UCL
- centrosome duplication Source: GO_Central
- ciliary basal body-plasma membrane docking Source: Reactome
- establishment or maintenance of microtubule cytoskeleton polarity Source: HGNC-UCL
- G2/M transition of mitotic cell cycle Source: Reactome
- microtubule depolymerization Source: ARUK-UCL
- microtubule polymerization Source: GO_Central
- mitotic spindle organization Source: GO_Central
- positive regulation of microtubule nucleation Source: CACAO
- regulation of G2/M transition of mitotic cell cycle Source: Reactome
- RNA transport Source: HGNC-UCL
- spindle organization Source: UniProtKB
Keywordsi
Biological process | Cell cycle, Cell division, Mitosis |
Enzyme and pathway databases
PathwayCommonsi | Q14008 |
Reactomei | R-HSA-141444, Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-2467813, Separation of Sister Chromatids R-HSA-2500257, Resolution of Sister Chromatid Cohesion R-HSA-2565942, Regulation of PLK1 Activity at G2/M Transition R-HSA-380259, Loss of Nlp from mitotic centrosomes R-HSA-380270, Recruitment of mitotic centrosome proteins and complexes R-HSA-380284, Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380320, Recruitment of NuMA to mitotic centrosomes R-HSA-5620912, Anchoring of the basal body to the plasma membrane R-HSA-5663220, RHO GTPases Activate Formins R-HSA-68877, Mitotic Prometaphase R-HSA-8854518, AURKA Activation by TPX2 R-HSA-9648025, EML4 and NUDC in mitotic spindle formation |
Names & Taxonomyi
Protein namesi | Recommended name: Cytoskeleton-associated protein 5Alternative name(s): Colonic and hepatic tumor overexpressed gene protein Short name: Ch-TOG |
Gene namesi | Name:CKAP5 Synonyms:KIAA0097 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:28959, CKAP5 |
MIMi | 611142, gene |
neXtProti | NX_Q14008 |
VEuPathDBi | HostDB:ENSG00000175216.14 |
Subcellular locationi
Cytoskeleton
- centrosome 4 Publications
- spindle pole 1 Publication
- spindle 3 Publications
Other locations
- kinetochore 1 Publication
Note: Detected on centrosomes and kinetochores during interphase and mitosis independently from TACC3 and clathrin. Located to spindle poles and microtubules during mitosis. In complex with TACC3 localized to microtubule plus-ends in mitosis and interphase. In complex with TACC3 and clathrin localized to inter-microtubule bridges in mitotic spindles. Accumulation sites at microtubule plus ends protruded approximately 100 nm from MAPRE1/EB1 sites in interphase cells.3 Publications
Cytoskeleton
- centrosome Source: UniProtKB
- spindle pole Source: UniProtKB
Cytosol
- cytosol Source: Reactome
Nucleus
- nucleolus Source: HPA
Plasma Membrane
- plasma membrane Source: HPA
Other locations
- condensed chromosome kinetochore Source: UniProtKB-SubCell
- cytoplasm Source: MGI
- kinetochore Source: UniProtKB
- membrane Source: UniProtKB
- protein-containing complex Source: MGI
Keywords - Cellular componenti
Centromere, Chromosome, Cytoplasm, Cytoskeleton, KinetochorePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 1939 | L → A or R: Disrupts interaction with TACC3. 1 Publication | 1 | |
Mutagenesisi | 1939 | L → A: Abolishes localization to spindle microtubules, no effect on localization to centrosomes and kinetochores; when associated with A-1942. 1 Publication | 1 | |
Mutagenesisi | 1942 | L → A or R: Disrupts interaction with TACC3. 1 Publication | 1 | |
Mutagenesisi | 1942 | L → A: Abolishes localization to spindle microtubules, no effect on localization to centrosomes and kinetochores; when associated with A-1939. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 9793 |
OpenTargetsi | ENSG00000175216 |
PharmGKBi | PA142672107 |
Miscellaneous databases
Pharosi | Q14008, Tbio |
Genetic variation databases
BioMutai | CKAP5 |
DMDMi | 212276513 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000089663 | 1 – 2032 | Cytoskeleton-associated protein 5Add BLAST | 2032 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 48 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 816 | PhosphoserineCombined sources | 1 | |
Modified residuei | 845 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1469 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1861 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | Q14008 |
jPOSTi | Q14008 |
MassIVEi | Q14008 |
MaxQBi | Q14008 |
PaxDbi | Q14008 |
PeptideAtlasi | Q14008 |
PRIDEi | Q14008 |
ProteomicsDBi | 59791 [Q14008-1] 59792 [Q14008-2] 59793 [Q14008-3] |
PTM databases
CarbonylDBi | Q14008 |
GlyGeni | Q14008, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q14008 |
MetOSitei | Q14008 |
PhosphoSitePlusi | Q14008 |
SwissPalmi | Q14008 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000175216, Expressed in ventricular zone and 242 other tissues |
ExpressionAtlasi | Q14008, baseline and differential |
Genevisiblei | Q14008, HS |
Organism-specific databases
HPAi | ENSG00000175216, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with TACC1 (PubMed:11903063).
Interacts with SLAIN2 and SLAIN1 (PubMed:21646404).
Interacts with HNRNPA2B1 (PubMed:15703215).
Interacts with TACC3 independently of clathrin (PubMed:25596274).
Interacts with TACC3 and clathrin forming the TACC3/ch-TOG/clathrin complex located at spindle inter-microtubules bridges (PubMed:21297582, PubMed:23532825).
Interacts with NDC80; indicative for an association with the NDC80 complex (PubMed:27156448).
7 PublicationsBinary interactionsi
Hide detailsQ14008
GO - Molecular functioni
- cadherin binding Source: BHF-UCL
- microtubule binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 115137, 176 interactors |
CORUMi | Q14008 |
IntActi | Q14008, 89 interactors |
MINTi | Q14008 |
STRINGi | 9606.ENSP00000432768 |
Miscellaneous databases
RNActi | Q14008, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q14008 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 159 – 197 | HEAT 1Add BLAST | 39 | |
Repeati | 356 – 394 | HEAT 2Add BLAST | 39 | |
Repeati | 434 – 472 | HEAT 3Add BLAST | 39 | |
Repeati | 750 – 788 | HEAT 4Add BLAST | 39 | |
Repeati | 855 – 893 | HEAT 5Add BLAST | 39 | |
Repeati | 936 – 974 | HEAT 6Add BLAST | 39 | |
Repeati | 1013 – 1051 | HEAT 7Add BLAST | 39 | |
Repeati | 1284 – 1322 | HEAT 8Add BLAST | 39 | |
Repeati | 1324 – 1357 | HEAT 9Add BLAST | 34 | |
Repeati | 1361 – 1399 | HEAT 10Add BLAST | 39 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 223 | TOG 11 PublicationAdd BLAST | 223 | |
Regioni | 268 – 502 | TOG 21 PublicationAdd BLAST | 235 | |
Regioni | 588 – 817 | TOG 31 PublicationAdd BLAST | 230 | |
Regioni | 853 – 1081 | TOG 41 PublicationAdd BLAST | 229 | |
Regioni | 1193 – 1428 | TOG 51 PublicationAdd BLAST | 236 | |
Regioni | 1932 – 1957 | Interaction with TACC31 PublicationAdd BLAST | 26 |
Domaini
Sequence similaritiesi
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG1820, Eukaryota |
GeneTreei | ENSGT00390000014757 |
HOGENOMi | CLU_000539_2_1_1 |
InParanoidi | Q14008 |
OMAi | KWIRDAL |
OrthoDBi | 33681at2759 |
PhylomeDBi | Q14008 |
TreeFami | TF105639 |
Family and domain databases
Gene3Di | 1.25.10.10, 5 hits |
InterProi | View protein in InterPro IPR011989, ARM-like IPR016024, ARM-type_fold IPR024395, CLASP_N_dom IPR021133, HEAT_type_2 IPR034085, TOG |
Pfami | View protein in Pfam PF12348, CLASP_N, 3 hits |
SMARTi | View protein in SMART SM01349, TOG, 5 hits |
SUPFAMi | SSF48371, SSF48371, 2 hits |
PROSITEi | View protein in PROSITE PS50077, HEAT_REPEAT, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MGDDSEWLKL PVDQKCEHKL WKARLSGYEE ALKIFQKIKD EKSPEWSKFL
60 70 80 90 100
GLIKKFVTDS NAVVQLKGLE AALVYVENAH VAGKTTGEVV SGVVSKVFNQ
110 120 130 140 150
PKAKAKELGI EICLMYIEIE KGEAVQEELL KGLDNKNPKI IVACIETLRK
160 170 180 190 200
ALSEFGSKII LLKPIIKVLP KLFESREKAV RDEAKLIAVE IYRWIRDALR
210 220 230 240 250
PPLQNINSVQ LKELEEEWVK LPTSAPRPTR FLRSQQELEA KLEQQQSAGG
260 270 280 290 300
DAEGGGDDGD EVPQIDAYEL LEAVEILSKL PKDFYDKIEA KKWQERKEAL
310 320 330 340 350
ESVEVLIKNP KLEAGDYADL VKALKKVVGK DTNVMLVALA AKCLTGLAVG
360 370 380 390 400
LRKKFGQYAG HVVPTILEKF KEKKPQVVQA LQEAIDAIFL TTTLQNISED
410 420 430 440 450
VLAVMDNKNP TIKQQTSLFI ARSFRHCTAS TLPKSLLKPF CAALLKHIND
460 470 480 490 500
SAPEVRDAAF EALGTALKVV GEKAVNPFLA DVDKLKLDKI KECSEKVELI
510 520 530 540 550
HGKKAGLAAD KKEFKPLPGR TAASGAAGDK DTKDISAPKP GPLKKAPAAK
560 570 580 590 600
AGGPPKKGKP AAPGGAGNTG TKNKKGLETK EIVEPELSIE VCEEKASAVL
610 620 630 640 650
PPTCIQLLDS SNWKERLACM EEFQKAVELM DRTEMPCQAL VRMLAKKPGW
660 670 680 690 700
KETNFQVMQM KLHIVALIAQ KGNFSKTSAQ VVLDGLVDKI GDVKCGNNAK
710 720 730 740 750
EAMTAIAEAC MLPWTAEQVV SMAFSQKNPK NQSETLNWLS NAIKEFGFSG
760 770 780 790 800
LNVKAFISNV KTALAATNPA VRTAAITLLG VMYLYVGPSL RMFFEDEKPA
810 820 830 840 850
LLSQIDAEFE KMQGQSPPAP TRGISKHSTS GTDEGEDGDE PDDGSNDVVD
860 870 880 890 900
LLPRTEISDK ITSELVSKIG DKNWKIRKEG LDEVAGIIND AKFIQPNIGE
910 920 930 940 950
LPTALKGRLN DSNKILVQQT LNILQQLAVA MGPNIKQHVK NLGIPIITVL
960 970 980 990 1000
GDSKNNVRAA ALATVNAWAE QTGMKEWLEG EDLSEELKKE NPFLRQELLG
1010 1020 1030 1040 1050
WLAEKLPTLR STPTDLILCV PHLYSCLEDR NGDVRKKAQD ALPFFMMHLG
1060 1070 1080 1090 1100
YEKMAKATGK LKPTSKDQVL AMLEKAKVNM PAKPAPPTKA TSKPMGGSAP
1110 1120 1130 1140 1150
AKFQPASAPA EDCISSSTEP KPDPKKAKAP GLSSKAKSAQ GKKMPSKTSL
1160 1170 1180 1190 1200
KEDEDKSGPI FIVVPNGKEQ RMKDEKGLKV LKWNFTTPRD EYIEQLKTQM
1210 1220 1230 1240 1250
SSCVAKWLQD EMFHSDFQHH NKALAVMVDH LESEKEGVIG CLDLILKWLT
1260 1270 1280 1290 1300
LRFFDTNTSV LMKALEYLKL LFTLLSEEEY HLTENEASSF IPYLVVKVGE
1310 1320 1330 1340 1350
PKDVIRKDVR AILNRMCLVY PASKMFPFIM EGTKSKNSKQ RAECLEELGC
1360 1370 1380 1390 1400
LVESYGMNVC QPTPGKALKE IAVHIGDRDN AVRNAALNTI VTVYNVHGDQ
1410 1420 1430 1440 1450
VFKLIGNLSE KDMSMLEERI KRSAKRPSAA PIKQVEEKPQ RAQNISSNAN
1460 1470 1480 1490 1500
MLRKGPAEDM SSKLNQARSM SGHPEAAQMV RREFQLDLDE IENDNGTVRC
1510 1520 1530 1540 1550
EMPELVQHKL DDIFEPVLIP EPKIRAVSPH FDDMHSNTAS TINFIISQVA
1560 1570 1580 1590 1600
SGDINTSIQA LTQIDEVLRQ EDKAEAMSGH IDQFLIATFM QLRLIYNTHM
1610 1620 1630 1640 1650
ADEKLEKDEI IKLYSCIIGN MISLFQIESL AREASTGVLK DLMHGLITLM
1660 1670 1680 1690 1700
LDSRIEDLEE GQQVIRSVNL LVVKVLEKSD QTNILSALLV LLQDSLLATA
1710 1720 1730 1740 1750
SSPKFSELVM KCLWRMVRLL PDTINSINLD RILLDIHIFM KVFPKEKLKQ
1760 1770 1780 1790 1800
CKSEFPIRTL KTLLHTLCKL KGPKILDHLT MIDNKNESEL EAHLCRMMKH
1810 1820 1830 1840 1850
SMDQTGSKSD KETEKGASRI DEKSSKAKVN DFLAEIFKKI GSKENTKEGL
1860 1870 1880 1890 1900
AELYEYKKKY SDADIEPFLK NSSQFFQSYV ERGLRVIEME REGKGRISTS
1910 1920 1930 1940 1950
TGISPQMEVT CVPTPTSTVS SIGNTNGEEV GPSVYLERLK ILRQRCGLDN
1960 1970 1980 1990 2000
TKQDDRPPLT SLLSKPAVPT VASSTDMLHS KLSQLRESRE QHQHSDLDSN
2010 2020 2030
QTHSSGTVTS SSSTANIDDL KKRLERIKSS RK
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH0YCF6 | H0YCF6_HUMAN | Cytoskeleton-associated protein 5 | CKAP5 | 166 | Annotation score: | ||
H0YEK7 | H0YEK7_HUMAN | Cytoskeleton-associated protein 5 | CKAP5 | 190 | Annotation score: | ||
H0YDX5 | H0YDX5_HUMAN | Cytoskeleton-associated protein 5 | CKAP5 | 203 | Annotation score: | ||
E9PQH5 | E9PQH5_HUMAN | Cytoskeleton-associated protein 5 | CKAP5 | 151 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 476 | N → K in CAA63212 (PubMed:8536682).Curated | 1 | |
Sequence conflicti | 476 | N → K in BAA07892 (PubMed:7788527).Curated | 1 | |
Sequence conflicti | 1814 | E → A in CAA63212 (PubMed:8536682).Curated | 1 | |
Sequence conflicti | 1822 | E → A in CAA63212 (PubMed:8536682).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_045627 | 785 | Y → C. Corresponds to variant dbSNP:rs11038988Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_035668 | 1564 – 1623 | Missing in isoform 2. 1 PublicationAdd BLAST | 60 | |
Alternative sequenceiVSP_036400 | 1774 | K → KSCMCLPQ in isoform 3. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X92474 mRNA Translation: CAA63212.1 D43948 mRNA Translation: BAA07892.2 Different initiation. AC115088 Genomic DNA No translation available. BC017856 mRNA Translation: AAH17856.1 Sequence problems. BC070136 mRNA Translation: AAH70136.1 Sequence problems. BC111043 mRNA Translation: AAI11044.1 Sequence problems. BC120869 mRNA Translation: AAI20870.1 BC120870 mRNA Translation: AAI20871.1 Frameshift. |
CCDSi | CCDS31477.1 [Q14008-1] CCDS7924.1 [Q14008-2] |
PIRi | S68176 |
RefSeqi | NP_001008938.1, NM_001008938.3 [Q14008-1] NP_055571.2, NM_014756.3 [Q14008-2] |
Genome annotation databases
Ensembli | ENST00000312055; ENSP00000310227; ENSG00000175216 [Q14008-2] ENST00000354558; ENSP00000346566; ENSG00000175216 [Q14008-2] ENST00000529230; ENSP00000432768; ENSG00000175216 [Q14008-1] |
GeneIDi | 9793 |
KEGGi | hsa:9793 |
UCSCi | uc001ndi.3, human [Q14008-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X92474 mRNA Translation: CAA63212.1 D43948 mRNA Translation: BAA07892.2 Different initiation. AC115088 Genomic DNA No translation available. BC017856 mRNA Translation: AAH17856.1 Sequence problems. BC070136 mRNA Translation: AAH70136.1 Sequence problems. BC111043 mRNA Translation: AAI11044.1 Sequence problems. BC120869 mRNA Translation: AAI20870.1 BC120870 mRNA Translation: AAI20871.1 Frameshift. |
CCDSi | CCDS31477.1 [Q14008-1] CCDS7924.1 [Q14008-2] |
PIRi | S68176 |
RefSeqi | NP_001008938.1, NM_001008938.3 [Q14008-1] NP_055571.2, NM_014756.3 [Q14008-2] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4QMI | X-ray | 1.90 | A/B | 846-1081 | [»] | |
4QMJ | X-ray | 2.50 | A | 846-1081 | [»] | |
SMRi | Q14008 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 115137, 176 interactors |
CORUMi | Q14008 |
IntActi | Q14008, 89 interactors |
MINTi | Q14008 |
STRINGi | 9606.ENSP00000432768 |
PTM databases
CarbonylDBi | Q14008 |
GlyGeni | Q14008, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q14008 |
MetOSitei | Q14008 |
PhosphoSitePlusi | Q14008 |
SwissPalmi | Q14008 |
Genetic variation databases
BioMutai | CKAP5 |
DMDMi | 212276513 |
Proteomic databases
EPDi | Q14008 |
jPOSTi | Q14008 |
MassIVEi | Q14008 |
MaxQBi | Q14008 |
PaxDbi | Q14008 |
PeptideAtlasi | Q14008 |
PRIDEi | Q14008 |
ProteomicsDBi | 59791 [Q14008-1] 59792 [Q14008-2] 59793 [Q14008-3] |
Protocols and materials databases
Antibodypediai | 26445, 128 antibodies |
Genome annotation databases
Ensembli | ENST00000312055; ENSP00000310227; ENSG00000175216 [Q14008-2] ENST00000354558; ENSP00000346566; ENSG00000175216 [Q14008-2] ENST00000529230; ENSP00000432768; ENSG00000175216 [Q14008-1] |
GeneIDi | 9793 |
KEGGi | hsa:9793 |
UCSCi | uc001ndi.3, human [Q14008-1] |
Organism-specific databases
CTDi | 9793 |
DisGeNETi | 9793 |
GeneCardsi | CKAP5 |
HGNCi | HGNC:28959, CKAP5 |
HPAi | ENSG00000175216, Low tissue specificity |
MIMi | 611142, gene |
neXtProti | NX_Q14008 |
OpenTargetsi | ENSG00000175216 |
PharmGKBi | PA142672107 |
VEuPathDBi | HostDB:ENSG00000175216.14 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1820, Eukaryota |
GeneTreei | ENSGT00390000014757 |
HOGENOMi | CLU_000539_2_1_1 |
InParanoidi | Q14008 |
OMAi | KWIRDAL |
OrthoDBi | 33681at2759 |
PhylomeDBi | Q14008 |
TreeFami | TF105639 |
Enzyme and pathway databases
PathwayCommonsi | Q14008 |
Reactomei | R-HSA-141444, Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-2467813, Separation of Sister Chromatids R-HSA-2500257, Resolution of Sister Chromatid Cohesion R-HSA-2565942, Regulation of PLK1 Activity at G2/M Transition R-HSA-380259, Loss of Nlp from mitotic centrosomes R-HSA-380270, Recruitment of mitotic centrosome proteins and complexes R-HSA-380284, Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380320, Recruitment of NuMA to mitotic centrosomes R-HSA-5620912, Anchoring of the basal body to the plasma membrane R-HSA-5663220, RHO GTPases Activate Formins R-HSA-68877, Mitotic Prometaphase R-HSA-8854518, AURKA Activation by TPX2 R-HSA-9648025, EML4 and NUDC in mitotic spindle formation |
Miscellaneous databases
BioGRID-ORCSi | 9793, 783 hits in 1000 CRISPR screens |
ChiTaRSi | CKAP5, human |
GeneWikii | CKAP5 |
GenomeRNAii | 9793 |
Pharosi | Q14008, Tbio |
PROi | PR:Q14008 |
RNActi | Q14008, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000175216, Expressed in ventricular zone and 242 other tissues |
ExpressionAtlasi | Q14008, baseline and differential |
Genevisiblei | Q14008, HS |
Family and domain databases
Gene3Di | 1.25.10.10, 5 hits |
InterProi | View protein in InterPro IPR011989, ARM-like IPR016024, ARM-type_fold IPR024395, CLASP_N_dom IPR021133, HEAT_type_2 IPR034085, TOG |
Pfami | View protein in Pfam PF12348, CLASP_N, 3 hits |
SMARTi | View protein in SMART SM01349, TOG, 5 hits |
SUPFAMi | SSF48371, SSF48371, 2 hits |
PROSITEi | View protein in PROSITE PS50077, HEAT_REPEAT, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CKAP5_HUMAN | |
Accessioni | Q14008Primary (citable) accession number: Q14008 Secondary accession number(s): Q05D70 Q6NSH4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1998 |
Last sequence update: | November 4, 2008 | |
Last modified: | April 7, 2021 | |
This is version 197 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families