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Entry version 191 (22 Apr 2020)
Sequence version 3 (04 Nov 2008)
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Protein

Cytoskeleton-associated protein 5

Gene

CKAP5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Acts as processive microtubule polymerase. Promotes cytoplasmic microtubule nucleation and elongation. Plays a major role in organizing spindle poles. In spindle formation protects kinetochore microtubules from depolymerization by KIF2C and has an essential role in centrosomal microtubule assembly independently of KIF2C activity. Contributes to centrosome integrity. Acts as component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:23532825). Enhances the strength of NDC80 complex-mediated kinetochore-tip microtubule attachments (PubMed:27156448).7 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell cycle, Cell division, Mitosis

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-HSA-2467813 Separation of Sister Chromatids
R-HSA-2500257 Resolution of Sister Chromatid Cohesion
R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition
R-HSA-380259 Loss of Nlp from mitotic centrosomes
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes
R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centrosome
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes
R-HSA-5620912 Anchoring of the basal body to the plasma membrane
R-HSA-5663220 RHO GTPases Activate Formins
R-HSA-68877 Mitotic Prometaphase
R-HSA-8854518 AURKA Activation by TPX2
R-HSA-9648025 EML4 and NUDC in mitotic spindle formation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cytoskeleton-associated protein 5
Alternative name(s):
Colonic and hepatic tumor overexpressed gene protein
Short name:
Ch-TOG
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CKAP5
Synonyms:KIAA0097
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:28959 CKAP5

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
611142 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q14008

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Centromere, Chromosome, Cytoplasm, Cytoskeleton, Kinetochore

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi1939L → A or R: Disrupts interaction with TACC3. 1 Publication1
Mutagenesisi1939L → A: Abolishes localization to spindle microtubules, no effect on localization to centrosomes and kinetochores; when associated with A-1942. 1 Publication1
Mutagenesisi1942L → A or R: Disrupts interaction with TACC3. 1 Publication1
Mutagenesisi1942L → A: Abolishes localization to spindle microtubules, no effect on localization to centrosomes and kinetochores; when associated with A-1939. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
9793

Open Targets

More...
OpenTargetsi
ENSG00000175216

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142672107

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q14008 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CKAP5

Domain mapping of disease mutations (DMDM)

More...
DMDMi
212276513

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000896631 – 2032Cytoskeleton-associated protein 5Add BLAST2032

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei48N6-acetyllysineCombined sources1
Modified residuei816PhosphoserineCombined sources1
Modified residuei845PhosphoserineCombined sources1
Modified residuei1469PhosphoserineCombined sources1
Modified residuei1861PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q14008

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q14008

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q14008

MaxQB - The MaxQuant DataBase

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MaxQBi
Q14008

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q14008

PeptideAtlas

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PeptideAtlasi
Q14008

PRoteomics IDEntifications database

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PRIDEi
Q14008

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
59791 [Q14008-1]
59792 [Q14008-2]
59793 [Q14008-3]

PTM databases

CarbonylDB database of protein carbonylation sites

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CarbonylDBi
Q14008

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q14008

MetOSite database of methionine sulfoxide sites

More...
MetOSitei
Q14008

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q14008

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q14008

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Overexpressed in hepatomas and colonic tumors. Also expressed in skeletal muscle, brain, heart, placenta, lung, liver, kidney and pancreas. Expression is elevated in the brain; highly expressed in the Purkinje cell bodies of the cerebellum.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000175216 Expressed in kidney and 231 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q14008 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q14008 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000175216 Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with TACC1 (PubMed:11903063).

Interacts with SLAIN2 and SLAIN1 (PubMed:21646404).

Interacts with HNRNPA2B1 (PubMed:15703215).

Interacts with TACC3 independently of clathrin (PubMed:25596274).

Interacts with TACC3 and clathrin forming the TACC3/ch-TOG/clathrin complex located at spindle inter-microtubules bridges (PubMed:21297582, PubMed:23532825).

Interacts with NDC80; indicative for an association with the NDC80 complex (PubMed:27156448).

7 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
115137, 143 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q14008

Protein interaction database and analysis system

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IntActi
Q14008, 85 interactors

Molecular INTeraction database

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MINTi
Q14008

STRING: functional protein association networks

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STRINGi
9606.ENSP00000432768

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q14008 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

12032
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q14008

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati159 – 197HEAT 1Add BLAST39
Repeati356 – 394HEAT 2Add BLAST39
Repeati434 – 472HEAT 3Add BLAST39
Repeati750 – 788HEAT 4Add BLAST39
Repeati855 – 893HEAT 5Add BLAST39
Repeati936 – 974HEAT 6Add BLAST39
Repeati1013 – 1051HEAT 7Add BLAST39
Repeati1284 – 1322HEAT 8Add BLAST39
Repeati1324 – 1357HEAT 9Add BLAST34
Repeati1361 – 1399HEAT 10Add BLAST39

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 223TOG 11 PublicationAdd BLAST223
Regioni268 – 502TOG 21 PublicationAdd BLAST235
Regioni588 – 817TOG 31 PublicationAdd BLAST230
Regioni853 – 1081TOG 41 PublicationAdd BLAST229
Regioni1193 – 1428TOG 51 PublicationAdd BLAST236
Regioni1932 – 1957Interaction with TACC31 PublicationAdd BLAST26

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The TOG (tumor overexpressed gene) domains are arranged in a N-terminal pentameric array with each domain composed of six (for the most part non-canonical) HEAT repeats forming a oblong paddle-like structure. Intra-HEAT loops are positioned along a face of the TOG domain and bind to a single alpha/beta-tubulin heterodimer. The TOG domains in the array seem to be structurally and functionally polarized. Differential functions may range from microtubule (MT) lattice binding and/or free tubulin heterodimer binding to potentiating stable incorporation of tubulin into the MT lattice.1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TOG/XMAP215 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1820 Eukaryota
ENOG410XPTW LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000014757

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_000539_2_1_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q14008

KEGG Orthology (KO)

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KOi
K16803

Identification of Orthologs from Complete Genome Data

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OMAi
KWIRDAL

Database of Orthologous Groups

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OrthoDBi
33681at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q14008

TreeFam database of animal gene trees

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TreeFami
TF105639

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.25.10.10, 5 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR024395 CLASP_N_dom
IPR021133 HEAT_type_2
IPR034085 TOG

Pfam protein domain database

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Pfami
View protein in Pfam
PF12348 CLASP_N, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01349 TOG, 5 hits

Superfamily database of structural and functional annotation

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SUPFAMi
SSF48371 SSF48371, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50077 HEAT_REPEAT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q14008-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGDDSEWLKL PVDQKCEHKL WKARLSGYEE ALKIFQKIKD EKSPEWSKFL
60 70 80 90 100
GLIKKFVTDS NAVVQLKGLE AALVYVENAH VAGKTTGEVV SGVVSKVFNQ
110 120 130 140 150
PKAKAKELGI EICLMYIEIE KGEAVQEELL KGLDNKNPKI IVACIETLRK
160 170 180 190 200
ALSEFGSKII LLKPIIKVLP KLFESREKAV RDEAKLIAVE IYRWIRDALR
210 220 230 240 250
PPLQNINSVQ LKELEEEWVK LPTSAPRPTR FLRSQQELEA KLEQQQSAGG
260 270 280 290 300
DAEGGGDDGD EVPQIDAYEL LEAVEILSKL PKDFYDKIEA KKWQERKEAL
310 320 330 340 350
ESVEVLIKNP KLEAGDYADL VKALKKVVGK DTNVMLVALA AKCLTGLAVG
360 370 380 390 400
LRKKFGQYAG HVVPTILEKF KEKKPQVVQA LQEAIDAIFL TTTLQNISED
410 420 430 440 450
VLAVMDNKNP TIKQQTSLFI ARSFRHCTAS TLPKSLLKPF CAALLKHIND
460 470 480 490 500
SAPEVRDAAF EALGTALKVV GEKAVNPFLA DVDKLKLDKI KECSEKVELI
510 520 530 540 550
HGKKAGLAAD KKEFKPLPGR TAASGAAGDK DTKDISAPKP GPLKKAPAAK
560 570 580 590 600
AGGPPKKGKP AAPGGAGNTG TKNKKGLETK EIVEPELSIE VCEEKASAVL
610 620 630 640 650
PPTCIQLLDS SNWKERLACM EEFQKAVELM DRTEMPCQAL VRMLAKKPGW
660 670 680 690 700
KETNFQVMQM KLHIVALIAQ KGNFSKTSAQ VVLDGLVDKI GDVKCGNNAK
710 720 730 740 750
EAMTAIAEAC MLPWTAEQVV SMAFSQKNPK NQSETLNWLS NAIKEFGFSG
760 770 780 790 800
LNVKAFISNV KTALAATNPA VRTAAITLLG VMYLYVGPSL RMFFEDEKPA
810 820 830 840 850
LLSQIDAEFE KMQGQSPPAP TRGISKHSTS GTDEGEDGDE PDDGSNDVVD
860 870 880 890 900
LLPRTEISDK ITSELVSKIG DKNWKIRKEG LDEVAGIIND AKFIQPNIGE
910 920 930 940 950
LPTALKGRLN DSNKILVQQT LNILQQLAVA MGPNIKQHVK NLGIPIITVL
960 970 980 990 1000
GDSKNNVRAA ALATVNAWAE QTGMKEWLEG EDLSEELKKE NPFLRQELLG
1010 1020 1030 1040 1050
WLAEKLPTLR STPTDLILCV PHLYSCLEDR NGDVRKKAQD ALPFFMMHLG
1060 1070 1080 1090 1100
YEKMAKATGK LKPTSKDQVL AMLEKAKVNM PAKPAPPTKA TSKPMGGSAP
1110 1120 1130 1140 1150
AKFQPASAPA EDCISSSTEP KPDPKKAKAP GLSSKAKSAQ GKKMPSKTSL
1160 1170 1180 1190 1200
KEDEDKSGPI FIVVPNGKEQ RMKDEKGLKV LKWNFTTPRD EYIEQLKTQM
1210 1220 1230 1240 1250
SSCVAKWLQD EMFHSDFQHH NKALAVMVDH LESEKEGVIG CLDLILKWLT
1260 1270 1280 1290 1300
LRFFDTNTSV LMKALEYLKL LFTLLSEEEY HLTENEASSF IPYLVVKVGE
1310 1320 1330 1340 1350
PKDVIRKDVR AILNRMCLVY PASKMFPFIM EGTKSKNSKQ RAECLEELGC
1360 1370 1380 1390 1400
LVESYGMNVC QPTPGKALKE IAVHIGDRDN AVRNAALNTI VTVYNVHGDQ
1410 1420 1430 1440 1450
VFKLIGNLSE KDMSMLEERI KRSAKRPSAA PIKQVEEKPQ RAQNISSNAN
1460 1470 1480 1490 1500
MLRKGPAEDM SSKLNQARSM SGHPEAAQMV RREFQLDLDE IENDNGTVRC
1510 1520 1530 1540 1550
EMPELVQHKL DDIFEPVLIP EPKIRAVSPH FDDMHSNTAS TINFIISQVA
1560 1570 1580 1590 1600
SGDINTSIQA LTQIDEVLRQ EDKAEAMSGH IDQFLIATFM QLRLIYNTHM
1610 1620 1630 1640 1650
ADEKLEKDEI IKLYSCIIGN MISLFQIESL AREASTGVLK DLMHGLITLM
1660 1670 1680 1690 1700
LDSRIEDLEE GQQVIRSVNL LVVKVLEKSD QTNILSALLV LLQDSLLATA
1710 1720 1730 1740 1750
SSPKFSELVM KCLWRMVRLL PDTINSINLD RILLDIHIFM KVFPKEKLKQ
1760 1770 1780 1790 1800
CKSEFPIRTL KTLLHTLCKL KGPKILDHLT MIDNKNESEL EAHLCRMMKH
1810 1820 1830 1840 1850
SMDQTGSKSD KETEKGASRI DEKSSKAKVN DFLAEIFKKI GSKENTKEGL
1860 1870 1880 1890 1900
AELYEYKKKY SDADIEPFLK NSSQFFQSYV ERGLRVIEME REGKGRISTS
1910 1920 1930 1940 1950
TGISPQMEVT CVPTPTSTVS SIGNTNGEEV GPSVYLERLK ILRQRCGLDN
1960 1970 1980 1990 2000
TKQDDRPPLT SLLSKPAVPT VASSTDMLHS KLSQLRESRE QHQHSDLDSN
2010 2020 2030
QTHSSGTVTS SSSTANIDDL KKRLERIKSS RK
Length:2,032
Mass (Da):225,495
Last modified:November 4, 2008 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB2BBFB1CF2ED688B
GO
Isoform 2 (identifier: Q14008-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1564-1623: Missing.

Show »
Length:1,972
Mass (Da):218,525
Checksum:i17596E610D1B7FC9
GO
Isoform 3 (identifier: Q14008-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1774-1774: K → KSCMCLPQ

Show »
Length:2,039
Mass (Da):226,258
Checksum:i94281848BC2A3952
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YEK7H0YEK7_HUMAN
Cytoskeleton-associated protein 5
CKAP5
190Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YCF6H0YCF6_HUMAN
Cytoskeleton-associated protein 5
CKAP5
166Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YDX5H0YDX5_HUMAN
Cytoskeleton-associated protein 5
CKAP5
203Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PQH5E9PQH5_HUMAN
Cytoskeleton-associated protein 5
CKAP5
151Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH17856 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAH70136 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAI11044 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAI20871 differs from that shown. Reason: Frameshift.Curated
The sequence BAA07892 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti476N → K in CAA63212 (PubMed:8536682).Curated1
Sequence conflicti476N → K in BAA07892 (PubMed:7788527).Curated1
Sequence conflicti1814E → A in CAA63212 (PubMed:8536682).Curated1
Sequence conflicti1822E → A in CAA63212 (PubMed:8536682).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_045627785Y → C. Corresponds to variant dbSNP:rs11038988Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0356681564 – 1623Missing in isoform 2. 1 PublicationAdd BLAST60
Alternative sequenceiVSP_0364001774K → KSCMCLPQ in isoform 3. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X92474 mRNA Translation: CAA63212.1
D43948 mRNA Translation: BAA07892.2 Different initiation.
AC115088 Genomic DNA No translation available.
BC017856 mRNA Translation: AAH17856.1 Sequence problems.
BC070136 mRNA Translation: AAH70136.1 Sequence problems.
BC111043 mRNA Translation: AAI11044.1 Sequence problems.
BC120869 mRNA Translation: AAI20870.1
BC120870 mRNA Translation: AAI20871.1 Frameshift.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS31477.1 [Q14008-1]
CCDS7924.1 [Q14008-2]

Protein sequence database of the Protein Information Resource

More...
PIRi
S68176

NCBI Reference Sequences

More...
RefSeqi
NP_001008938.1, NM_001008938.3 [Q14008-1]
NP_055571.2, NM_014756.3 [Q14008-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000312055; ENSP00000310227; ENSG00000175216 [Q14008-2]
ENST00000354558; ENSP00000346566; ENSG00000175216 [Q14008-2]
ENST00000529230; ENSP00000432768; ENSG00000175216 [Q14008-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
9793

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:9793

UCSC genome browser

More...
UCSCi
uc001ndi.3 human [Q14008-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X92474 mRNA Translation: CAA63212.1
D43948 mRNA Translation: BAA07892.2 Different initiation.
AC115088 Genomic DNA No translation available.
BC017856 mRNA Translation: AAH17856.1 Sequence problems.
BC070136 mRNA Translation: AAH70136.1 Sequence problems.
BC111043 mRNA Translation: AAI11044.1 Sequence problems.
BC120869 mRNA Translation: AAI20870.1
BC120870 mRNA Translation: AAI20871.1 Frameshift.
CCDSiCCDS31477.1 [Q14008-1]
CCDS7924.1 [Q14008-2]
PIRiS68176
RefSeqiNP_001008938.1, NM_001008938.3 [Q14008-1]
NP_055571.2, NM_014756.3 [Q14008-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4QMIX-ray1.90A/B846-1081[»]
4QMJX-ray2.50A846-1081[»]
SMRiQ14008
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi115137, 143 interactors
CORUMiQ14008
IntActiQ14008, 85 interactors
MINTiQ14008
STRINGi9606.ENSP00000432768

PTM databases

CarbonylDBiQ14008
iPTMnetiQ14008
MetOSiteiQ14008
PhosphoSitePlusiQ14008
SwissPalmiQ14008

Polymorphism and mutation databases

BioMutaiCKAP5
DMDMi212276513

Proteomic databases

EPDiQ14008
jPOSTiQ14008
MassIVEiQ14008
MaxQBiQ14008
PaxDbiQ14008
PeptideAtlasiQ14008
PRIDEiQ14008
ProteomicsDBi59791 [Q14008-1]
59792 [Q14008-2]
59793 [Q14008-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
26445 118 antibodies

Genome annotation databases

EnsembliENST00000312055; ENSP00000310227; ENSG00000175216 [Q14008-2]
ENST00000354558; ENSP00000346566; ENSG00000175216 [Q14008-2]
ENST00000529230; ENSP00000432768; ENSG00000175216 [Q14008-1]
GeneIDi9793
KEGGihsa:9793
UCSCiuc001ndi.3 human [Q14008-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9793
DisGeNETi9793

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CKAP5
HGNCiHGNC:28959 CKAP5
HPAiENSG00000175216 Low tissue specificity
MIMi611142 gene
neXtProtiNX_Q14008
OpenTargetsiENSG00000175216
PharmGKBiPA142672107

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1820 Eukaryota
ENOG410XPTW LUCA
GeneTreeiENSGT00390000014757
HOGENOMiCLU_000539_2_1_1
InParanoidiQ14008
KOiK16803
OMAiKWIRDAL
OrthoDBi33681at2759
PhylomeDBiQ14008
TreeFamiTF105639

Enzyme and pathway databases

ReactomeiR-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-HSA-2467813 Separation of Sister Chromatids
R-HSA-2500257 Resolution of Sister Chromatid Cohesion
R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition
R-HSA-380259 Loss of Nlp from mitotic centrosomes
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes
R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centrosome
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes
R-HSA-5620912 Anchoring of the basal body to the plasma membrane
R-HSA-5663220 RHO GTPases Activate Formins
R-HSA-68877 Mitotic Prometaphase
R-HSA-8854518 AURKA Activation by TPX2
R-HSA-9648025 EML4 and NUDC in mitotic spindle formation

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CKAP5 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
CKAP5

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
9793
PharosiQ14008 Tbio

Protein Ontology

More...
PROi
PR:Q14008
RNActiQ14008 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000175216 Expressed in kidney and 231 other tissues
ExpressionAtlasiQ14008 baseline and differential
GenevisibleiQ14008 HS

Family and domain databases

Gene3Di1.25.10.10, 5 hits
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR024395 CLASP_N_dom
IPR021133 HEAT_type_2
IPR034085 TOG
PfamiView protein in Pfam
PF12348 CLASP_N, 2 hits
SMARTiView protein in SMART
SM01349 TOG, 5 hits
SUPFAMiSSF48371 SSF48371, 2 hits
PROSITEiView protein in PROSITE
PS50077 HEAT_REPEAT, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCKAP5_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q14008
Secondary accession number(s): Q05D70
, Q0VAX7, Q0VAX8, Q14668, Q2TA89, Q6NSH4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 4, 2008
Last modified: April 22, 2020
This is version 191 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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