UniProtKB - Q14004 (CDK13_HUMAN)
Cyclin-dependent kinase 13
CDK13
Functioni
Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, probably by phosphorylating SRSF1/SF2. Required during hematopoiesis. In case of infection by HIV-1 virus, interacts with HIV-1 Tat protein acetylated at 'Lys-50' and 'Lys-51', thereby increasing HIV-1 mRNA splicing and promoting the production of the doubly spliced HIV-1 protein Nef.
4 PublicationsCatalytic activityi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 734 | ATPPROSITE-ProRule annotation | 1 | |
Active sitei | 837 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 711 – 719 | ATPPROSITE-ProRule annotation | 9 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- cyclin binding Source: MGI
- cyclin-dependent protein serine/threonine kinase activity Source: GO_Central
- protein kinase activity Source: ProtInc
- protein kinase binding Source: Ensembl
- protein serine/threonine/tyrosine kinase activity Source: RHEA
- protein serine kinase activity Source: RHEA
- RNA binding Source: UniProtKB
- RNA polymerase II CTD heptapeptide repeat kinase activity Source: UniProtKB
GO - Biological processi
- alternative mRNA splicing, via spliceosome Source: UniProtKB
- hemopoiesis Source: UniProtKB
- multicellular organism development Source: ProtInc
- negative regulation of stem cell differentiation Source: Ensembl
- phosphorylation of RNA polymerase II C-terminal domain Source: UniProtKB
- positive regulation of cell population proliferation Source: ProtInc
- positive regulation of transcription elongation from RNA polymerase II promoter Source: ComplexPortal
- protein phosphorylation Source: GO_Central
- regulation of mitotic nuclear division Source: ProtInc
- regulation of signal transduction Source: ComplexPortal
- transcription elongation from RNA polymerase II promoter Source: GO_Central
Keywordsi
Molecular function | Kinase, Serine/threonine-protein kinase, Transferase |
Biological process | Host-virus interaction, mRNA processing, mRNA splicing |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BRENDAi | 2.7.11.22, 2681 2.7.11.23, 2681 |
PathwayCommonsi | Q14004 |
Reactomei | R-HSA-6796648, TP53 Regulates Transcription of DNA Repair Genes R-HSA-6798695, Neutrophil degranulation |
SignaLinki | Q14004 |
SIGNORi | Q14004 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:CDK13 Synonyms:CDC2L, CDC2L5, CHED, KIAA1791 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:1733, CDK13 |
MIMi | 603309, gene |
neXtProti | NX_Q14004 |
VEuPathDBi | HostDB:ENSG00000065883 |
Subcellular locationi
Nucleus
- Nucleus speckle 1 Publication
Cytosol
- cytosol Source: HPA
Extracellular region or secreted
- extracellular region Source: Reactome
- extracellular space Source: UniProtKB
Golgi apparatus
- Golgi apparatus Source: HPA
Nucleus
- cyclin/CDK positive transcription elongation factor complex Source: GO_Central
- nuclear cyclin-dependent protein kinase holoenzyme complex Source: UniProtKB
- nuclear speck Source: UniProtKB
- nucleoplasm Source: Reactome
- nucleus Source: GO_Central
Other locations
- cyclin K-CDK13 complex Source: MGI
- cyclin-dependent protein kinase holoenzyme complex Source: GO_Central
- ficolin-1-rich granule lumen Source: Reactome
Keywords - Cellular componenti
NucleusPathology & Biotechi
Involvement in diseasei
Congenital heart defects, dysmorphic facial features, and intellectual developmental disorder (CHDFIDD)2 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_078598 | 714 | G → R in CHDFIDD. 1 PublicationCorresponds to variant dbSNP:rs1057519633EnsemblClinVar. | 1 | |
Natural variantiVAR_078599 | 717 | G → R in CHDFIDD. 1 PublicationCorresponds to variant dbSNP:rs1057519632EnsemblClinVar. | 1 | |
Natural variantiVAR_079422 | 734 | K → E in CHDFIDD. 1 PublicationCorresponds to variant dbSNP:rs1064795731EnsemblClinVar. | 1 | |
Natural variantiVAR_078600 | 751 | R → Q in CHDFIDD. 1 PublicationCorresponds to variant dbSNP:rs1057519634EnsemblClinVar. | 1 | |
Natural variantiVAR_079423 | 842 | N → D in CHDFIDD. 1 PublicationCorresponds to variant dbSNP:rs1554333853EnsemblClinVar. | 1 | |
Natural variantiVAR_078601 | 842 | N → S in CHDFIDD. 2 PublicationsCorresponds to variant dbSNP:rs878853160EnsemblClinVar. | 1 |
Keywords - Diseasei
Disease variant, Mental retardationOrganism-specific databases
DisGeNETi | 8621 |
GeneReviewsi | CDK13 |
MalaCardsi | CDK13 |
MIMi | 617360, phenotype |
OpenTargetsi | ENSG00000065883 |
PharmGKBi | PA26264 |
Miscellaneous databases
Pharosi | Q14004, Tchem |
Chemistry databases
ChEMBLi | CHEMBL1795192 |
GuidetoPHARMACOLOGYi | 1966 |
Genetic variation databases
BioMutai | CDK13 |
DMDMi | 66774048 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000085711 | 1 – 1512 | Cyclin-dependent kinase 13Add BLAST | 1512 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 315 | PhosphoserineCombined sources | 1 | |
Modified residuei | 317 | PhosphoserineCombined sources | 1 | |
Modified residuei | 325 | PhosphoserineCombined sources | 1 | |
Modified residuei | 340 | PhosphoserineCombined sources | 1 | |
Modified residuei | 342 | PhosphoserineCombined sources | 1 | |
Modified residuei | 358 | PhosphoserineCombined sources | 1 | |
Modified residuei | 360 | PhosphoserineCombined sources | 1 | |
Modified residuei | 383 | PhosphoserineCombined sources | 1 | |
Modified residuei | 395 | PhosphoserineCombined sources | 1 | |
Modified residuei | 397 | PhosphoserineCombined sources | 1 | |
Modified residuei | 400 | PhosphoserineCombined sources | 1 | |
Modified residuei | 437 | PhosphoserineCombined sources | 1 | |
Modified residuei | 439 | PhosphoserineCombined sources | 1 | |
Cross-linki | 519 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 525 | PhosphoserineCombined sources | 1 | |
Cross-linki | 547 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 556 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 588 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 871 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 1048 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1058 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 1246 | PhosphothreonineCombined sources | 1 |
Keywords - PTMi
Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q14004 |
jPOSTi | Q14004 |
MassIVEi | Q14004 |
MaxQBi | Q14004 |
PaxDbi | Q14004 |
PeptideAtlasi | Q14004 |
PRIDEi | Q14004 |
ProteomicsDBi | 59786 [Q14004-1] 59787 [Q14004-2] |
PTM databases
GlyGeni | Q14004, 6 sites, 2 O-linked glycans (6 sites) |
iPTMneti | Q14004 |
PhosphoSitePlusi | Q14004 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000065883, Expressed in inferior vagus X ganglion and 258 other tissues |
ExpressionAtlasi | Q14004, baseline and differential |
Genevisiblei | Q14004, HS |
Organism-specific databases
HPAi | ENSG00000065883, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with CCNL1 and CCNL2 (By similarity).
Interacts with CCNK.
Interacts with C1QBP.
By similarity2 Publications(Microbial infection) Interacts with HIV-1 Tat.
1 PublicationBinary interactionsi
Q14004
With | #Exp. | IntAct |
---|---|---|
CCNK [O75909] | 6 | EBI-968626,EBI-739806 |
Isoform 2 [Q14004-2]
With | #Exp. | IntAct |
---|---|---|
C1QBP [Q07021] | 6 | EBI-6375898,EBI-347528 |
GO - Molecular functioni
- cyclin binding Source: MGI
- protein kinase binding Source: Ensembl
Protein-protein interaction databases
BioGRIDi | 114176, 108 interactors |
ComplexPortali | CPX-359, Cyclin K-CDK13 complex |
IntActi | Q14004, 47 interactors |
MINTi | Q14004 |
STRINGi | 9606.ENSP00000181839 |
Chemistry databases
BindingDBi | Q14004 |
Miscellaneous databases
RNActi | Q14004, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q14004 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 705 – 998 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 294 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 20 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 30 – 60 | DisorderedSequence analysisAdd BLAST | 31 | |
Regioni | 75 – 545 | DisorderedSequence analysisAdd BLAST | 471 | |
Regioni | 566 – 596 | DisorderedSequence analysisAdd BLAST | 31 | |
Regioni | 654 – 685 | DisorderedSequence analysisAdd BLAST | 32 | |
Regioni | 1025 – 1084 | DisorderedSequence analysisAdd BLAST | 60 | |
Regioni | 1138 – 1170 | DisorderedSequence analysisAdd BLAST | 33 | |
Regioni | 1201 – 1231 | DisorderedSequence analysisAdd BLAST | 31 | |
Regioni | 1245 – 1273 | DisorderedSequence analysisAdd BLAST | 29 | |
Regioni | 1379 – 1400 | DisorderedSequence analysisAdd BLAST | 22 | |
Regioni | 1468 – 1512 | DisorderedSequence analysisAdd BLAST | 45 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 39 – 60 | Pro residuesSequence analysisAdd BLAST | 22 | |
Compositional biasi | 190 – 205 | Basic and acidic residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 218 – 244 | Basic and acidic residuesSequence analysisAdd BLAST | 27 | |
Compositional biasi | 245 – 269 | Polar residuesSequence analysisAdd BLAST | 25 | |
Compositional biasi | 270 – 319 | Basic and acidic residuesSequence analysisAdd BLAST | 50 | |
Compositional biasi | 327 – 347 | Polar residuesSequence analysisAdd BLAST | 21 | |
Compositional biasi | 362 – 410 | Polar residuesSequence analysisAdd BLAST | 49 | |
Compositional biasi | 411 – 433 | Basic residuesSequence analysisAdd BLAST | 23 | |
Compositional biasi | 434 – 451 | Polar residuesSequence analysisAdd BLAST | 18 | |
Compositional biasi | 487 – 511 | Polar residuesSequence analysisAdd BLAST | 25 | |
Compositional biasi | 569 – 592 | Basic and acidic residuesSequence analysisAdd BLAST | 24 | |
Compositional biasi | 1052 – 1081 | Polar residuesSequence analysisAdd BLAST | 30 | |
Compositional biasi | 1140 – 1170 | Polar residuesSequence analysisAdd BLAST | 31 | |
Compositional biasi | 1468 – 1499 | Polar residuesSequence analysisAdd BLAST | 32 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0600, Eukaryota |
GeneTreei | ENSGT00940000157852 |
HOGENOMi | CLU_004166_3_0_1 |
InParanoidi | Q14004 |
OrthoDBi | 925637at2759 |
PhylomeDBi | Q14004 |
TreeFami | TF101060 |
Family and domain databases
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 11 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MPSSSDTALG GGGGLSWAEK KLEERRKRRR FLSPQQPPLL LPLLQPQLLQ
60 70 80 90 100
PPPPPPPLLF LAAPGTAAAA AAAAAASSSC FSPGPPLEVK RLARGKRRAG
110 120 130 140 150
GRQKRRRGPR AGQEAEKRRV FSLPQPQQDG GGGASSGGGV TPLVEYEDVS
160 170 180 190 200
SQSEQGLLLG GASAATAATA AGGTGGSGGS PASSSGTQRR GEGSERRPRR
210 220 230 240 250
DRRSSSGRSK ERHREHRRRD GQRGGSEASK SRSRHSHSGE ERAEVAKSGS
260 270 280 290 300
SSSSGGRRKS ASATSSSSSS RKDRDSKAHR SRTKSSKEPP SAYKEPPKAY
310 320 330 340 350
REDKTEPKAY RRRRSLSPLG GRDDSPVSHR ASQSLRSRKS PSPAGGGSSP
360 370 380 390 400
YSRRLPRSPS PYSRRRSPSY SRHSSYERGG DVSPSPYSSS SWRRSRSPYS
410 420 430 440 450
PVLRRSGKSR SRSPYSSRHS RSRSRHRLSR SRSRHSSISP STLTLKSSLA
460 470 480 490 500
AELNKNKKAR AAEAARAAEA AKAAEATKAA EAAAKAAKAS NTSTPTKGNT
510 520 530 540 550
ETSASASQTN HVKDVKKIKI EHAPSPSSGG TLKNDKAKTK PPLQVTKVEN
560 570 580 590 600
NLIVDKATKK AVIVGKESKS AATKEESVSL KEKTKPLTPS IGAKEKEQHV
610 620 630 640 650
ALVTSTLPPL PLPPMLPEDK EADSLRGNIS VKAVKKEVEK KLRCLLADLP
660 670 680 690 700
LPPELPGGDD LSKSPEEKKT ATQLHSKRRP KICGPRYGET KEKDIDWGKR
710 720 730 740 750
CVDKFDIIGI IGEGTYGQVY KARDKDTGEM VALKKVRLDN EKEGFPITAI
760 770 780 790 800
REIKILRQLT HQSIINMKEI VTDKEDALDF KKDKGAFYLV FEYMDHDLMG
810 820 830 840 850
LLESGLVHFN ENHIKSFMRQ LMEGLDYCHK KNFLHRDIKC SNILLNNRGQ
860 870 880 890 900
IKLADFGLAR LYSSEESRPY TNKVITLWYR PPELLLGEER YTPAIDVWSC
910 920 930 940 950
GCILGELFTK KPIFQANQEL AQLELISRIC GSPCPAVWPD VIKLPYFNTM
960 970 980 990 1000
KPKKQYRRKL REEFVFIPAA ALDLFDYMLA LDPSKRCTAE QALQCEFLRD
1010 1020 1030 1040 1050
VEPSKMPPPD LPLWQDCHEL WSKKRRRQKQ MGMTDDVSTI KAPRKDLSLG
1060 1070 1080 1090 1100
LDDSRTNTPQ GVLPSSQLKS QGSSNVAPVK TGPGQHLNHS ELAILLNLLQ
1110 1120 1130 1140 1150
SKTSVNMADF VQVLNIKVNS ETQQQLNKIN LPAGILATGE KQTDPSTPQQ
1160 1170 1180 1190 1200
ESSKPLGGIQ PSSQTIQPKV ETDAAQAAVQ SAFAVLLTQL IKAQQSKQKD
1210 1220 1230 1240 1250
VLLEERENGS GHEASLQLRP PPEPSTPVSG QDDLIQHQDM RILELTPEPD
1260 1270 1280 1290 1300
RPRILPPDQR PPEPPEPPPV TEEDLDYRTE NQHVPTTSSS LTDPHAGVKA
1310 1320 1330 1340 1350
ALLQLLAQHQ PQDDPKREGG IDYQAGDTYV STSDYKDNFG SSSFSSAPYV
1360 1370 1380 1390 1400
SNDGLGSSSA PPLERRSFIG NSDIQSLDNY STASSHSGGP PQPSAFSESF
1410 1420 1430 1440 1450
PSSVAGYGDI YLNAGPMLFS GDKDHRFEYS HGPIAVLANS SDPSTGPEST
1460 1470 1480 1490 1500
HPLPAKMHNY NYGGNLQENP SGPSLMHGQT WTSPAQGPGY SQGYRGHIST
1510
STGRGRGRGL PY
Computationally mapped potential isoform sequencesi
There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A2R8YD28 | A0A2R8YD28_HUMAN | Cyclin-dependent kinase 13 | CDK13 | 456 | Annotation score: | ||
Q9BVE2 | Q9BVE2_HUMAN | CDC2L5 protein | CDK13 | 324 | Annotation score: | ||
A0A087X209 | A0A087X209_HUMAN | Cyclin-dependent kinase 13 | CDK13 | 418 | Annotation score: | ||
A0A2R8Y4Z0 | A0A2R8Y4Z0_HUMAN | Cyclin-dependent kinase 13 | CDK13 | 1,308 | Annotation score: | ||
A0A2R8YF61 | A0A2R8YF61_HUMAN | Cyclin-dependent kinase 13 | CDK13 | 915 | Annotation score: | ||
A0A2R8Y7W5 | A0A2R8Y7W5_HUMAN | Cyclin-dependent kinase 13 | CDK13 | 1,099 | Annotation score: | ||
A0A2R8Y644 | A0A2R8Y644_HUMAN | Cyclin-dependent kinase 13 | CDK13 | 239 | Annotation score: | ||
A0A2R8Y7Y0 | A0A2R8Y7Y0_HUMAN | Cyclin-dependent kinase 13 | CDK13 | 257 | Annotation score: | ||
A0A2R8YCQ1 | A0A2R8YCQ1_HUMAN | Cyclin-dependent kinase 13 | CDK13 | 288 | Annotation score: | ||
A0A2R8YFE7 | A0A2R8YFE7_HUMAN | Cyclin-dependent kinase 13 | CDK13 | 279 | Annotation score: | ||
There is more potential isoformShow all |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 21 | K → R in CAC10400 (PubMed:11162436).Curated | 1 | |
Sequence conflicti | 21 | K → R in CAC10401 (PubMed:11162436).Curated | 1 | |
Sequence conflicti | 671 | A → T in CAC10400 (PubMed:11162436).Curated | 1 | |
Sequence conflicti | 671 | A → T in CAC10401 (PubMed:11162436).Curated | 1 | |
Sequence conflicti | 671 | A → T in AAA58424 (PubMed:1731328).Curated | 1 | |
Sequence conflicti | 810 | N → Y in AAA58424 (PubMed:1731328).Curated | 1 | |
Sequence conflicti | 862 – 866 | YSSEE → FSVFF in BAB47420 (Ref. 5) Curated | 5 | |
Sequence conflicti | 1180 | Q → R in BAD96773 (Ref. 5) Curated | 1 | |
Sequence conflicti | 1356 | G → E in BAD96773 (Ref. 5) Curated | 1 |
RNA editingi
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_066526 | 103 | Q → R in RNA edited version. | 1 | |
Natural variantiVAR_053926 | 340 | S → F. Corresponds to variant dbSNP:rs13622Ensembl. | 1 | |
Natural variantiVAR_022381 | 356 | P → A1 PublicationCorresponds to variant dbSNP:rs17537669EnsemblClinVar. | 1 | |
Natural variantiVAR_022382 | 403 | L → F1 PublicationCorresponds to variant dbSNP:rs3735137EnsemblClinVar. | 1 | |
Natural variantiVAR_022383 | 410 | R → Q1 PublicationCorresponds to variant dbSNP:rs17496261Ensembl. | 1 | |
Natural variantiVAR_041965 | 494 | T → A1 PublicationCorresponds to variant dbSNP:rs34624759Ensembl. | 1 | |
Natural variantiVAR_022384 | 500 | T → A2 PublicationsCorresponds to variant dbSNP:rs3735135Ensembl. | 1 | |
Natural variantiVAR_022385 | 624 | S → G1 PublicationCorresponds to variant dbSNP:rs17496275EnsemblClinVar. | 1 | |
Natural variantiVAR_041966 | 670 | T → R1 PublicationCorresponds to variant dbSNP:rs34775357EnsemblClinVar. | 1 | |
Natural variantiVAR_022386 | 700 | R → L2 PublicationsCorresponds to variant dbSNP:rs1057000Ensembl. | 1 | |
Natural variantiVAR_078598 | 714 | G → R in CHDFIDD. 1 PublicationCorresponds to variant dbSNP:rs1057519633EnsemblClinVar. | 1 | |
Natural variantiVAR_078599 | 717 | G → R in CHDFIDD. 1 PublicationCorresponds to variant dbSNP:rs1057519632EnsemblClinVar. | 1 | |
Natural variantiVAR_079422 | 734 | K → E in CHDFIDD. 1 PublicationCorresponds to variant dbSNP:rs1064795731EnsemblClinVar. | 1 | |
Natural variantiVAR_078600 | 751 | R → Q in CHDFIDD. 1 PublicationCorresponds to variant dbSNP:rs1057519634EnsemblClinVar. | 1 | |
Natural variantiVAR_079423 | 842 | N → D in CHDFIDD. 1 PublicationCorresponds to variant dbSNP:rs1554333853EnsemblClinVar. | 1 | |
Natural variantiVAR_078601 | 842 | N → S in CHDFIDD. 2 PublicationsCorresponds to variant dbSNP:rs878853160EnsemblClinVar. | 1 | |
Natural variantiVAR_022387 | 1062 | V → M1 PublicationCorresponds to variant dbSNP:rs17496712EnsemblClinVar. | 1 | |
Natural variantiVAR_041967 | 1170 | V → M2 PublicationsCorresponds to variant dbSNP:rs3204309EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_013579 | 1079 – 1138 | Missing in isoform 2. 2 PublicationsAdd BLAST | 60 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ297709 mRNA Translation: CAC10400.1 AJ297710 mRNA Translation: CAC10401.1 AY679523 Genomic DNA Translation: AAT74623.1 AC072061 Genomic DNA Translation: AAS07490.1 Sequence problems. AC072061 Genomic DNA Translation: AAS07491.1 AC006023 Genomic DNA Translation: AAD54514.1 M80629 mRNA Translation: AAA58424.1 Frameshift. AK223053 mRNA Translation: BAD96773.1 AB058694 mRNA Translation: BAB47420.1 |
CCDSi | CCDS5461.1 [Q14004-1] CCDS5462.1 [Q14004-2] |
PIRi | A38197 |
RefSeqi | NP_003709.3, NM_003718.4 [Q14004-1] NP_112557.2, NM_031267.3 [Q14004-2] |
Genome annotation databases
Ensembli | ENST00000181839; ENSP00000181839; ENSG00000065883 ENST00000340829; ENSP00000340557; ENSG00000065883 [Q14004-2] |
GeneIDi | 8621 |
KEGGi | hsa:8621 |
MANE-Selecti | ENST00000181839.10; ENSP00000181839.4; NM_003718.5; NP_003709.3 |
UCSCi | uc003thh.5, human [Q14004-1] |
Keywords - Coding sequence diversityi
Alternative splicing, RNA editingSimilar proteinsi
Cross-referencesi
Web resourcesi
NIEHS-SNPs |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ297709 mRNA Translation: CAC10400.1 AJ297710 mRNA Translation: CAC10401.1 AY679523 Genomic DNA Translation: AAT74623.1 AC072061 Genomic DNA Translation: AAS07490.1 Sequence problems. AC072061 Genomic DNA Translation: AAS07491.1 AC006023 Genomic DNA Translation: AAD54514.1 M80629 mRNA Translation: AAA58424.1 Frameshift. AK223053 mRNA Translation: BAD96773.1 AB058694 mRNA Translation: BAB47420.1 |
CCDSi | CCDS5461.1 [Q14004-1] CCDS5462.1 [Q14004-2] |
PIRi | A38197 |
RefSeqi | NP_003709.3, NM_003718.4 [Q14004-1] NP_112557.2, NM_031267.3 [Q14004-2] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5EFQ | X-ray | 2.00 | A/C | 694-1039 | [»] | |
7NXJ | X-ray | 2.36 | A/C | 694-1039 | [»] | |
SMRi | Q14004 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 114176, 108 interactors |
ComplexPortali | CPX-359, Cyclin K-CDK13 complex |
IntActi | Q14004, 47 interactors |
MINTi | Q14004 |
STRINGi | 9606.ENSP00000181839 |
Chemistry databases
BindingDBi | Q14004 |
ChEMBLi | CHEMBL1795192 |
GuidetoPHARMACOLOGYi | 1966 |
PTM databases
GlyGeni | Q14004, 6 sites, 2 O-linked glycans (6 sites) |
iPTMneti | Q14004 |
PhosphoSitePlusi | Q14004 |
Genetic variation databases
BioMutai | CDK13 |
DMDMi | 66774048 |
Proteomic databases
EPDi | Q14004 |
jPOSTi | Q14004 |
MassIVEi | Q14004 |
MaxQBi | Q14004 |
PaxDbi | Q14004 |
PeptideAtlasi | Q14004 |
PRIDEi | Q14004 |
ProteomicsDBi | 59786 [Q14004-1] 59787 [Q14004-2] |
Protocols and materials databases
Antibodypediai | 26726, 205 antibodies from 28 providers |
DNASUi | 8621 |
Genome annotation databases
Ensembli | ENST00000181839; ENSP00000181839; ENSG00000065883 ENST00000340829; ENSP00000340557; ENSG00000065883 [Q14004-2] |
GeneIDi | 8621 |
KEGGi | hsa:8621 |
MANE-Selecti | ENST00000181839.10; ENSP00000181839.4; NM_003718.5; NP_003709.3 |
UCSCi | uc003thh.5, human [Q14004-1] |
Organism-specific databases
CTDi | 8621 |
DisGeNETi | 8621 |
GeneCardsi | CDK13 |
GeneReviewsi | CDK13 |
HGNCi | HGNC:1733, CDK13 |
HPAi | ENSG00000065883, Low tissue specificity |
MalaCardsi | CDK13 |
MIMi | 603309, gene 617360, phenotype |
neXtProti | NX_Q14004 |
OpenTargetsi | ENSG00000065883 |
PharmGKBi | PA26264 |
VEuPathDBi | HostDB:ENSG00000065883 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0600, Eukaryota |
GeneTreei | ENSGT00940000157852 |
HOGENOMi | CLU_004166_3_0_1 |
InParanoidi | Q14004 |
OrthoDBi | 925637at2759 |
PhylomeDBi | Q14004 |
TreeFami | TF101060 |
Enzyme and pathway databases
BRENDAi | 2.7.11.22, 2681 2.7.11.23, 2681 |
PathwayCommonsi | Q14004 |
Reactomei | R-HSA-6796648, TP53 Regulates Transcription of DNA Repair Genes R-HSA-6798695, Neutrophil degranulation |
SignaLinki | Q14004 |
SIGNORi | Q14004 |
Miscellaneous databases
BioGRID-ORCSi | 8621, 63 hits in 1078 CRISPR screens |
ChiTaRSi | CDK13, human |
GeneWikii | CDC2L5 |
GenomeRNAii | 8621 |
Pharosi | Q14004, Tchem |
PROi | PR:Q14004 |
RNActi | Q14004, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000065883, Expressed in inferior vagus X ganglion and 258 other tissues |
ExpressionAtlasi | Q14004, baseline and differential |
Genevisiblei | Q14004, HS |
Family and domain databases
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CDK13_HUMAN | |
Accessioni | Q14004Primary (citable) accession number: Q14004 Secondary accession number(s): Q53G78 Q9UDR4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 2000 |
Last sequence update: | May 10, 2005 | |
Last modified: | February 23, 2022 | |
This is version 206 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human and mouse protein kinases
Human and mouse protein kinases: classification and index - Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families