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UniProtKB - Q14004 (CDK13_HUMAN)

Entry version 200 (07 Oct 2020)
Sequence version 2 (10 May 2005)
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Protein

Cyclin-dependent kinase 13

Gene

CDK13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, probably by phosphorylating SRSF1/SF2. Required during hematopoiesis. In case of infection by HIV-1 virus, interacts with HIV-1 Tat protein acetylated at 'Lys-50' and 'Lys-51', thereby increasing HIV-1 mRNA splicing and promoting the production of the doubly spliced HIV-1 protein Nef.4 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei734ATPPROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei837Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi711 – 719ATPPROSITE-ProRule annotation9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
Biological processHost-virus interaction, mRNA processing, mRNA splicing
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q14004

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-6796648, TP53 Regulates Transcription of DNA Repair Genes
R-HSA-6798695, Neutrophil degranulation

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q14004

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q14004

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cyclin-dependent kinase 13 (EC:2.7.11.22, EC:2.7.11.23)
Alternative name(s):
CDC2-related protein kinase 5
Cell division cycle 2-like protein kinase 5
Cell division protein kinase 13
Short name:
hCDK13
Cholinesterase-related cell division controller
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CDK13
Synonyms:CDC2L, CDC2L5, CHED, KIAA1791
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000065883.14

Human Gene Nomenclature Database

More...HGNCi		HGNC:1733, CDK13

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		603309, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q14004

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Congenital heart defects, dysmorphic facial features, and intellectual developmental disorder (CHDFIDD)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal dominant syndrome characterized by atrial and/or ventricular septal congenital heart defects, facial dysmorphism with hypertelorism, upslanted palpebral fissures, epicanthal folds, ptosis, strabismus, posteriorly rotated ears, thin upper lip, and small mouth. Patients manifest global developmental delay, delayed walking and speech acquisition, and intellectual disability. Some patients have mild microcephaly, a small cerebral cortex, and agenesis of corpus callosum. More variable features include clinodactyly and/or camptodactyly of the fingers, hypotonia, and joint hypermobility.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_078598714G → R in CHDFIDD. 1 PublicationCorresponds to variant dbSNP:rs1057519633EnsemblClinVar.1
Natural variantiVAR_078599717G → R in CHDFIDD. 1 PublicationCorresponds to variant dbSNP:rs1057519632EnsemblClinVar.1
Natural variantiVAR_079422734K → E in CHDFIDD. 1 PublicationCorresponds to variant dbSNP:rs1064795731EnsemblClinVar.1
Natural variantiVAR_078600751R → Q in CHDFIDD. 1 PublicationCorresponds to variant dbSNP:rs1057519634EnsemblClinVar.1
Natural variantiVAR_079423842N → D in CHDFIDD. 1 PublicationCorresponds to variant dbSNP:rs1554333853EnsemblClinVar.1
Natural variantiVAR_078601842N → S in CHDFIDD. 2 PublicationsCorresponds to variant dbSNP:rs878853160EnsemblClinVar.1

Keywords - Diseasei

Disease mutation, Mental retardation

Organism-specific databases

DisGeNET

More...DisGeNETi		8621

MalaCards human disease database

More...MalaCardsi		CDK13
MIMi617360, phenotype

Open Targets

More...OpenTargetsi		ENSG00000065883

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA26264

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q14004, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL1795192

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		1966

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		CDK13

Domain mapping of disease mutations (DMDM)

More...DMDMi		66774048

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000857111 – 1512Cyclin-dependent kinase 13Add BLAST1512

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei315PhosphoserineCombined sources1
Modified residuei317PhosphoserineCombined sources1
Modified residuei325PhosphoserineCombined sources1
Modified residuei340PhosphoserineCombined sources1
Modified residuei342PhosphoserineCombined sources1
Modified residuei358PhosphoserineCombined sources1
Modified residuei360PhosphoserineCombined sources1
Modified residuei383PhosphoserineCombined sources1
Modified residuei395PhosphoserineCombined sources1
Modified residuei397PhosphoserineCombined sources1
Modified residuei400PhosphoserineCombined sources1
Modified residuei437PhosphoserineCombined sources1
Modified residuei439PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki519Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei525PhosphoserineCombined sources1
Cross-linki547Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei556N6-acetyllysineCombined sources1
Modified residuei588PhosphothreonineCombined sources1
Modified residuei871PhosphothreonineCombined sources1
Modified residuei1048PhosphoserineCombined sources1
Modified residuei1058PhosphothreonineBy similarity1
Modified residuei1246PhosphothreonineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q14004

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q14004

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q14004

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q14004

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q14004

PeptideAtlas

More...PeptideAtlasi		Q14004

PRoteomics IDEntifications database

More...PRIDEi		Q14004

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		59786 [Q14004-1]
59787 [Q14004-2]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q14004, 3 sites, 1 O-linked glycan (3 sites)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q14004

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q14004

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in fetal brain, liver, muscle and in adult brain. Also expressed in neuroblastoma and glioblastoma tumors.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000065883, Expressed in inferior vagus X ganglion and 257 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q14004, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q14004, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000065883, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with CCNL1 and CCNL2 (By similarity).

Interacts with CCNK.

Interacts with C1QBP.

By similarity2 Publications

(Microbial infection) Interacts with HIV-1 Tat.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		114176, 76 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-359, Cyclin K-CDK13 complex

Protein interaction database and analysis system

More...IntActi		Q14004, 47 interactors

Molecular INTeraction database

More...MINTi		Q14004

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000181839

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		Q14004

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q14004, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11512
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q14004

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini705 – 998Protein kinasePROSITE-ProRule annotationAdd BLAST294

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0600, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000157852

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_004166_3_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q14004

KEGG Orthology (KO)

More...KOi		K08819

Identification of Orthologs from Complete Genome Data

More...OMAi		QSMSTKV

Database of Orthologous Groups

More...OrthoDBi		925637at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q14004

TreeFam database of animal gene trees

More...TreeFami		TF101060

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011009, Kinase-like_dom_sf
IPR000719, Prot_kinase_dom
IPR017441, Protein_kinase_ATP_BS
IPR008271, Ser/Thr_kinase_AS

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00069, Pkinase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00220, S_TKc, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF56112, SSF56112, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00107, PROTEIN_KINASE_ATP, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00108, PROTEIN_KINASE_ST, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 11 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q14004-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPSSSDTALG GGGGLSWAEK KLEERRKRRR FLSPQQPPLL LPLLQPQLLQ 
        60         70         80         90        100
PPPPPPPLLF LAAPGTAAAA AAAAAASSSC FSPGPPLEVK RLARGKRRAG 
       110        120        130        140        150
GRQKRRRGPR AGQEAEKRRV FSLPQPQQDG GGGASSGGGV TPLVEYEDVS 
       160        170        180        190        200
SQSEQGLLLG GASAATAATA AGGTGGSGGS PASSSGTQRR GEGSERRPRR 
       210        220        230        240        250
DRRSSSGRSK ERHREHRRRD GQRGGSEASK SRSRHSHSGE ERAEVAKSGS 
       260        270        280        290        300
SSSSGGRRKS ASATSSSSSS RKDRDSKAHR SRTKSSKEPP SAYKEPPKAY 
       310        320        330        340        350
REDKTEPKAY RRRRSLSPLG GRDDSPVSHR ASQSLRSRKS PSPAGGGSSP 
       360        370        380        390        400
YSRRLPRSPS PYSRRRSPSY SRHSSYERGG DVSPSPYSSS SWRRSRSPYS 
       410        420        430        440        450
PVLRRSGKSR SRSPYSSRHS RSRSRHRLSR SRSRHSSISP STLTLKSSLA 
       460        470        480        490        500
AELNKNKKAR AAEAARAAEA AKAAEATKAA EAAAKAAKAS NTSTPTKGNT 
       510        520        530        540        550
ETSASASQTN HVKDVKKIKI EHAPSPSSGG TLKNDKAKTK PPLQVTKVEN 
       560        570        580        590        600
NLIVDKATKK AVIVGKESKS AATKEESVSL KEKTKPLTPS IGAKEKEQHV 
       610        620        630        640        650
ALVTSTLPPL PLPPMLPEDK EADSLRGNIS VKAVKKEVEK KLRCLLADLP 
       660        670        680        690        700
LPPELPGGDD LSKSPEEKKT ATQLHSKRRP KICGPRYGET KEKDIDWGKR 
       710        720        730        740        750
CVDKFDIIGI IGEGTYGQVY KARDKDTGEM VALKKVRLDN EKEGFPITAI 
       760        770        780        790        800
REIKILRQLT HQSIINMKEI VTDKEDALDF KKDKGAFYLV FEYMDHDLMG 
       810        820        830        840        850
LLESGLVHFN ENHIKSFMRQ LMEGLDYCHK KNFLHRDIKC SNILLNNRGQ 
       860        870        880        890        900
IKLADFGLAR LYSSEESRPY TNKVITLWYR PPELLLGEER YTPAIDVWSC 
       910        920        930        940        950
GCILGELFTK KPIFQANQEL AQLELISRIC GSPCPAVWPD VIKLPYFNTM 
       960        970        980        990       1000
KPKKQYRRKL REEFVFIPAA ALDLFDYMLA LDPSKRCTAE QALQCEFLRD 
      1010       1020       1030       1040       1050
VEPSKMPPPD LPLWQDCHEL WSKKRRRQKQ MGMTDDVSTI KAPRKDLSLG 
      1060       1070       1080       1090       1100
LDDSRTNTPQ GVLPSSQLKS QGSSNVAPVK TGPGQHLNHS ELAILLNLLQ 
      1110       1120       1130       1140       1150
SKTSVNMADF VQVLNIKVNS ETQQQLNKIN LPAGILATGE KQTDPSTPQQ 
      1160       1170       1180       1190       1200
ESSKPLGGIQ PSSQTIQPKV ETDAAQAAVQ SAFAVLLTQL IKAQQSKQKD 
      1210       1220       1230       1240       1250
VLLEERENGS GHEASLQLRP PPEPSTPVSG QDDLIQHQDM RILELTPEPD 
      1260       1270       1280       1290       1300
RPRILPPDQR PPEPPEPPPV TEEDLDYRTE NQHVPTTSSS LTDPHAGVKA 
      1310       1320       1330       1340       1350
ALLQLLAQHQ PQDDPKREGG IDYQAGDTYV STSDYKDNFG SSSFSSAPYV 
      1360       1370       1380       1390       1400
SNDGLGSSSA PPLERRSFIG NSDIQSLDNY STASSHSGGP PQPSAFSESF 
      1410       1420       1430       1440       1450
PSSVAGYGDI YLNAGPMLFS GDKDHRFEYS HGPIAVLANS SDPSTGPEST 
      1460       1470       1480       1490       1500
HPLPAKMHNY NYGGNLQENP SGPSLMHGQT WTSPAQGPGY SQGYRGHIST 
      1510 
STGRGRGRGL PY
Length:1,512
Mass (Da):164,923
Last modified:May 10, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3CA54A3585A2943D
GO
Isoform 2 (identifier: Q14004-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1079-1138: Missing.

Show »
Length:1,452
Mass (Da):158,435
Checksum:i8A8B712D8621EEA3
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2R8YD28A0A2R8YD28_HUMAN
Cyclin-dependent kinase 13
CDK13
456Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q9BVE2Q9BVE2_HUMAN
CDC2L5 protein
CDK13
324Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087X209A0A087X209_HUMAN
Cyclin-dependent kinase 13
CDK13
418Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Y4Z0A0A2R8Y4Z0_HUMAN
Cyclin-dependent kinase 13
CDK13
1,308Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Y7W5A0A2R8Y7W5_HUMAN
Cyclin-dependent kinase 13
CDK13
1,099Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8YF61A0A2R8YF61_HUMAN
Cyclin-dependent kinase 13
CDK13
915Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Y644A0A2R8Y644_HUMAN
Cyclin-dependent kinase 13
CDK13
239Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Y7Y0A0A2R8Y7Y0_HUMAN
Cyclin-dependent kinase 13
CDK13
257Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8YCQ1A0A2R8YCQ1_HUMAN
Cyclin-dependent kinase 13
CDK13
288Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8YFE7A0A2R8YFE7_HUMAN
Cyclin-dependent kinase 13
CDK13
279Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There is more potential isoformShow all

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA58424 differs from that shown. Reason: Frameshift.Curated
The sequence AAS07490 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti21K → R in CAC10400 (PubMed:11162436).Curated1
Sequence conflicti21K → R in CAC10401 (PubMed:11162436).Curated1
Sequence conflicti671A → T in CAC10400 (PubMed:11162436).Curated1
Sequence conflicti671A → T in CAC10401 (PubMed:11162436).Curated1
Sequence conflicti671A → T in AAA58424 (PubMed:1731328).Curated1
Sequence conflicti810N → Y in AAA58424 (PubMed:1731328).Curated1
Sequence conflicti862 – 866YSSEE → FSVFF in BAB47420 (Ref. 5) Curated5
Sequence conflicti1180Q → R in BAD96773 (Ref. 5) Curated1
Sequence conflicti1356G → E in BAD96773 (Ref. 5) Curated1

<p>This subsection of the 'Sequence' section provides information relevant to all types of RNA editing events (conversion, insertion, deletion of nucleotides) that lead to one or more amino acid changes compared to the translation of the non-edited RNA version.<p><a href='/help/rna_editing' target='_top'>More...</a></p>RNA editingi

Edited at position 103.1 Publication
Edited at about 88%.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_066526103Q → R in RNA edited version. 1
Natural variantiVAR_053926340S → F. Corresponds to variant dbSNP:rs13622Ensembl.1
Natural variantiVAR_022381356P → A1 PublicationCorresponds to variant dbSNP:rs17537669EnsemblClinVar.1
Natural variantiVAR_022382403L → F1 PublicationCorresponds to variant dbSNP:rs3735137EnsemblClinVar.1
Natural variantiVAR_022383410R → Q1 PublicationCorresponds to variant dbSNP:rs17496261Ensembl.1
Natural variantiVAR_041965494T → A1 PublicationCorresponds to variant dbSNP:rs34624759Ensembl.1
Natural variantiVAR_022384500T → A2 PublicationsCorresponds to variant dbSNP:rs3735135Ensembl.1
Natural variantiVAR_022385624S → G1 PublicationCorresponds to variant dbSNP:rs17496275EnsemblClinVar.1
Natural variantiVAR_041966670T → R1 PublicationCorresponds to variant dbSNP:rs34775357EnsemblClinVar.1
Natural variantiVAR_022386700R → L2 PublicationsCorresponds to variant dbSNP:rs1057000Ensembl.1
Natural variantiVAR_078598714G → R in CHDFIDD. 1 PublicationCorresponds to variant dbSNP:rs1057519633EnsemblClinVar.1
Natural variantiVAR_078599717G → R in CHDFIDD. 1 PublicationCorresponds to variant dbSNP:rs1057519632EnsemblClinVar.1
Natural variantiVAR_079422734K → E in CHDFIDD. 1 PublicationCorresponds to variant dbSNP:rs1064795731EnsemblClinVar.1
Natural variantiVAR_078600751R → Q in CHDFIDD. 1 PublicationCorresponds to variant dbSNP:rs1057519634EnsemblClinVar.1
Natural variantiVAR_079423842N → D in CHDFIDD. 1 PublicationCorresponds to variant dbSNP:rs1554333853EnsemblClinVar.1
Natural variantiVAR_078601842N → S in CHDFIDD. 2 PublicationsCorresponds to variant dbSNP:rs878853160EnsemblClinVar.1
Natural variantiVAR_0223871062V → M1 PublicationCorresponds to variant dbSNP:rs17496712EnsemblClinVar.1
Natural variantiVAR_0419671170V → M2 PublicationsCorresponds to variant dbSNP:rs3204309EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0135791079 – 1138Missing in isoform 2. 2 PublicationsAdd BLAST60

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AJ297709 mRNA Translation: CAC10400.1
AJ297710 mRNA Translation: CAC10401.1
AY679523 Genomic DNA Translation: AAT74623.1
AC072061 Genomic DNA Translation: AAS07490.1 Sequence problems.
AC072061 Genomic DNA Translation: AAS07491.1
AC006023 Genomic DNA Translation: AAD54514.1
M80629 mRNA Translation: AAA58424.1 Frameshift.
AK223053 mRNA Translation: BAD96773.1
AB058694 mRNA Translation: BAB47420.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS5461.1 [Q14004-1]
CCDS5462.1 [Q14004-2]

Protein sequence database of the Protein Information Resource

More...PIRi		A38197

NCBI Reference Sequences

More...RefSeqi		NP_003709.3, NM_003718.4 [Q14004-1]
NP_112557.2, NM_031267.3 [Q14004-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000181839; ENSP00000181839; ENSG00000065883 [Q14004-1]
ENST00000340829; ENSP00000340557; ENSG00000065883 [Q14004-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		8621

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:8621

UCSC genome browser

More...UCSCi		uc003thh.5, human [Q14004-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism, RNA editing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ297709 mRNA Translation: CAC10400.1
AJ297710 mRNA Translation: CAC10401.1
AY679523 Genomic DNA Translation: AAT74623.1
AC072061 Genomic DNA Translation: AAS07490.1 Sequence problems.
AC072061 Genomic DNA Translation: AAS07491.1
AC006023 Genomic DNA Translation: AAD54514.1
M80629 mRNA Translation: AAA58424.1 Frameshift.
AK223053 mRNA Translation: BAD96773.1
AB058694 mRNA Translation: BAB47420.1
CCDSiCCDS5461.1 [Q14004-1]
CCDS5462.1 [Q14004-2]
PIRiA38197
RefSeqiNP_003709.3, NM_003718.4 [Q14004-1]
NP_112557.2, NM_031267.3 [Q14004-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5EFQX-ray2.00A/C694-1039[»]
SMRiQ14004
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi114176, 76 interactors
ComplexPortaliCPX-359, Cyclin K-CDK13 complex
IntActiQ14004, 47 interactors
MINTiQ14004
STRINGi9606.ENSP00000181839

Chemistry databases

BindingDBiQ14004
ChEMBLiCHEMBL1795192
GuidetoPHARMACOLOGYi1966

PTM databases

GlyGeniQ14004, 3 sites, 1 O-linked glycan (3 sites)
iPTMnetiQ14004
PhosphoSitePlusiQ14004

Polymorphism and mutation databases

BioMutaiCDK13
DMDMi66774048

Proteomic databases

EPDiQ14004
jPOSTiQ14004
MassIVEiQ14004
MaxQBiQ14004
PaxDbiQ14004
PeptideAtlasiQ14004
PRIDEiQ14004
ProteomicsDBi59786 [Q14004-1]
59787 [Q14004-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		26726, 189 antibodies

The DNASU plasmid repository

More...DNASUi		8621

Genome annotation databases

EnsembliENST00000181839; ENSP00000181839; ENSG00000065883 [Q14004-1]
ENST00000340829; ENSP00000340557; ENSG00000065883 [Q14004-2]
GeneIDi8621
KEGGihsa:8621
UCSCiuc003thh.5, human [Q14004-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		8621
DisGeNETi8621
EuPathDBiHostDB:ENSG00000065883.14

GeneCards: human genes, protein and diseases

More...GeneCardsi		CDK13
HGNCiHGNC:1733, CDK13
HPAiENSG00000065883, Low tissue specificity
MalaCardsiCDK13
MIMi603309, gene
617360, phenotype
neXtProtiNX_Q14004
OpenTargetsiENSG00000065883
PharmGKBiPA26264

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0600, Eukaryota
GeneTreeiENSGT00940000157852
HOGENOMiCLU_004166_3_0_1
InParanoidiQ14004
KOiK08819
OMAiQSMSTKV
OrthoDBi925637at2759
PhylomeDBiQ14004
TreeFamiTF101060

Enzyme and pathway databases

PathwayCommonsiQ14004
ReactomeiR-HSA-6796648, TP53 Regulates Transcription of DNA Repair Genes
R-HSA-6798695, Neutrophil degranulation
SignaLinkiQ14004
SIGNORiQ14004

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		8621, 58 hits in 901 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		CDK13, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		CDC2L5

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		8621
PharosiQ14004, Tchem

Protein Ontology

More...PROi		PR:Q14004
RNActiQ14004, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000065883, Expressed in inferior vagus X ganglion and 257 other tissues
ExpressionAtlasiQ14004, baseline and differential
GenevisibleiQ14004, HS

Family and domain databases

InterProiView protein in InterPro
IPR011009, Kinase-like_dom_sf
IPR000719, Prot_kinase_dom
IPR017441, Protein_kinase_ATP_BS
IPR008271, Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069, Pkinase, 1 hit
SMARTiView protein in SMART
SM00220, S_TKc, 1 hit
SUPFAMiSSF56112, SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107, PROTEIN_KINASE_ATP, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00108, PROTEIN_KINASE_ST, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCDK13_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q14004
Secondary accession number(s): Q53G78
, Q6DKQ9, Q75MH4, Q75MH5, Q96JN4, Q9H4A0, Q9H4A1, Q9UDR4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 10, 2005
Last modified: October 7, 2020
This is version 200 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families
  6. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  7. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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