UniProtKB - Q14003 (KCNC3_HUMAN)
Potassium voltage-gated channel subfamily C member 3
KCNC3
Functioni
Voltage-gated potassium channel that plays an important role in the rapid repolarization of fast-firing brain neurons. The channel opens in response to the voltage difference across the membrane, forming a potassium-selective channel through which potassium ions pass in accordance with their electrochemical gradient. The channel displays rapid activation and inactivation kinetics (PubMed:10712820, PubMed:26997484, PubMed:22289912, PubMed:23734863, PubMed:16501573, PubMed:19953606, PubMed:21479265, PubMed:25756792).
It plays a role in the regulation of the frequency, shape and duration of action potentials in Purkinje cells. Required for normal survival of cerebellar neurons, probably via its role in regulating the duration and frequency of action potentials that in turn regulate the activity of voltage-gated Ca2+ channels and cellular Ca2+ homeostasis (By similarity).
Required for normal motor function (PubMed:23734863, PubMed:16501573, PubMed:19953606, PubMed:21479265, PubMed:25756792).
Plays a role in the reorganization of the cortical actin cytoskeleton and the formation of actin veil structures in neuronal growth cones via its interaction with HAX1 and the Arp2/3 complex (PubMed:26997484).
By similarity8 PublicationsGO - Molecular functioni
- delayed rectifier potassium channel activity Source: GO_Central
- voltage-gated potassium channel activity Source: UniProtKB
GO - Biological processi
- potassium ion transmembrane transport Source: UniProtKB
- protein homooligomerization Source: InterPro
- protein tetramerization Source: UniProtKB
- regulation of ion transmembrane transport Source: UniProtKB-KW
Keywordsi
Molecular function | Ion channel, Potassium channel, Voltage-gated channel |
Biological process | Ion transport, Potassium transport, Transport |
Ligand | Potassium |
Enzyme and pathway databases
PathwayCommonsi | Q14003 |
Reactomei | R-HSA-1296072, Voltage gated Potassium channels |
SignaLinki | Q14003 |
SIGNORi | Q14003 |
Protein family/group databases
TCDBi | 1.A.1.2.13, the voltage-gated ion channel (vic) superfamily |
Names & Taxonomyi
Protein namesi | Recommended name: Potassium voltage-gated channel subfamily C member 3Alternative name(s): KSHIIID Voltage-gated potassium channel subunit Kv3.3 |
Gene namesi | Name:KCNC3 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:6235, KCNC3 |
MIMi | 176264, gene |
neXtProti | NX_Q14003 |
VEuPathDBi | HostDB:ENSG00000131398 |
Subcellular locationi
Plasma membrane
- Cell membrane 9 Publications; Multi-pass membrane protein Sequence analysis
- presynaptic cell membrane By similarity; Multi-pass membrane protein Sequence analysis
- dendritic spine membrane By similarity; Multi-pass membrane protein Sequence analysis
Cytoskeleton
- cytoskeleton 1 Publication
Other locations
- Perikaryon By similarity
- axon By similarity
- dendrite By similarity
- cell cortex 1 Publication
Note: Detected on Purkinje cell dendritic spines, positioned perisynaptically but also in extrasynaptic positions along the spine membranes (By similarity). Detected at presynaptic calices of Held (By similarity). Colocalizes with the cortical actin cytoskeleton and the Arp2/3 complex (PubMed:26997484).By similarity1 Publication
Cytoskeleton
- cytoskeleton Source: UniProtKB-SubCell
Plasma Membrane
- dendrite membrane Source: GO_Central
- dendritic spine membrane Source: UniProtKB-SubCell
- neuronal cell body membrane Source: GO_Central
- plasma membrane Source: UniProtKB
- postsynaptic membrane Source: UniProtKB-KW
- presynaptic membrane Source: UniProtKB-SubCell
- voltage-gated potassium channel complex Source: UniProtKB
Other locations
- axon Source: GO_Central
- cell cortex Source: UniProtKB-SubCell
- integral component of membrane Source: GO_Central
- perikaryon Source: UniProtKB-SubCell
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 290 | CytoplasmicCuratedAdd BLAST | 290 | |
Transmembranei | 291 – 309 | Helical; Name=Segment S1Sequence analysisAdd BLAST | 19 | |
Transmembranei | 351 – 370 | Helical; Name=Segment S2Sequence analysisAdd BLAST | 20 | |
Topological domaini | 371 – 379 | CytoplasmicSequence analysis | 9 | |
Transmembranei | 380 – 398 | Helical; Name=Segment S3Sequence analysisAdd BLAST | 19 | |
Transmembranei | 412 – 434 | Helical; Voltage-sensor; Name=Segment S4Sequence analysisAdd BLAST | 23 | |
Topological domaini | 435 – 447 | CytoplasmicSequence analysisAdd BLAST | 13 | |
Transmembranei | 448 – 469 | Helical; Name=Segment S5Sequence analysisAdd BLAST | 22 | |
Transmembranei | 518 – 539 | Helical; Name=Segment S6Sequence analysisAdd BLAST | 22 | |
Topological domaini | 540 – 757 | CytoplasmicCuratedAdd BLAST | 218 |
Keywords - Cellular componenti
Cell junction, Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Membrane, Postsynaptic cell membrane, SynapsePathology & Biotechi
Involvement in diseasei
Spinocerebellar ataxia 13 (SCA13)7 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_074194 | 129 | D → N in SCA13; unknown pathological significance; changes channel activity; shifts the voltage dependence of activation. 1 Publication | 1 | |
Natural variantiVAR_074196 | 366 | R → H in SCA13; unknown pathological significance; dominant negative that decreases channel activity; decreases protein abundance; decreases protein stability; decreases localization to the plasma membrane; no effect on tetramerization. 2 PublicationsCorresponds to variant dbSNP:rs769502387Ensembl. | 1 | |
Natural variantiVAR_029530 | 420 | R → H in SCA13; dominant negative that induces loss of channel activity; decreases protein abundance; decreases protein stability; decreases localization to the plasma membrane and alters the localization of the wild-type protein; impairs N-glycosylation; no effect on tetramerization. 6 PublicationsCorresponds to variant dbSNP:rs104894699EnsemblClinVar. | 1 | |
Natural variantiVAR_074197 | 423 | R → H in SCA13; dominant negative that reduces channel activity; alters gating; decreases protein abundance; decreases localization to the plasma membrane; no effect on tetramerization. 5 PublicationsCorresponds to variant dbSNP:rs797044872EnsemblClinVar. | 1 | |
Natural variantiVAR_029531 | 448 | F → L in SCA13; alters gating; slows channel closing; decreases protein abundance; no effect on localization to the plasma membrane; no effect on N-glycosylation; no effect on tetramerization. 4 PublicationsCorresponds to variant dbSNP:rs104894700EnsemblClinVar. | 1 | |
Natural variantiVAR_074198 | 477 | D → N in SCA13; unknown pathological significance; no effect on channel activity. 1 PublicationCorresponds to variant dbSNP:rs148033381EnsemblClinVar. | 1 | |
Natural variantiVAR_074199 | 535 | V → M in SCA13; changes channel activity; shifts the voltage dependence of activation. 1 Publication | 1 | |
Natural variantiVAR_074200 | 591 | S → G in SCA13; unknown pathological significance; reduces channel activity; shifts the voltage dependence of activation. 1 PublicationCorresponds to variant dbSNP:rs549394447EnsemblClinVar. | 1 | |
Natural variantiVAR_074201 | 643 | G → S in SCA13; unknown pathological significance; no effect on channel activity. 1 PublicationCorresponds to variant dbSNP:rs778523009Ensembl. | 1 | |
Natural variantiVAR_074202 | 645 | P → R in SCA13; unknown pathological significance; no effect on channel activity. 1 PublicationCorresponds to variant dbSNP:rs1460306526Ensembl. | 1 | |
Natural variantiVAR_074203 | 746 | D → N in SCA13; unknown pathological significance; no effect on channel activity. 1 PublicationCorresponds to variant dbSNP:rs958323371Ensembl. | 1 |
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 1 – 78 | Missing : Loss of N-type inactivation. 1 PublicationAdd BLAST | 78 | |
Mutagenesisi | 366 | R → K or A: Decreases protein abundance. 1 Publication | 1 | |
Mutagenesisi | 420 | R → K or A: Decreases protein abundance. 1 Publication | 1 | |
Mutagenesisi | 423 | R → K or A: Decreases protein abundance. 1 Publication | 1 | |
Mutagenesisi | 592 | G → R: Loss of interaction with ACTR3. No effect on voltage-dependent channel opening or current amplitude, but decreased rate of inactivation during prolonged depolarization. 1 Publication | 1 |
Keywords - Diseasei
Disease variant, Neurodegeneration, Spinocerebellar ataxiaOrganism-specific databases
DisGeNETi | 3748 |
GeneReviewsi | KCNC3 |
MalaCardsi | KCNC3 |
MIMi | 605259, phenotype |
OpenTargetsi | ENSG00000131398 |
Orphaneti | 98768, Spinocerebellar ataxia type 13 |
PharmGKBi | PA30027 |
Miscellaneous databases
Pharosi | Q14003, Tclin |
Chemistry databases
ChEMBLi | CHEMBL2362996 |
DrugBanki | DB06637, Dalfampridine DB00228, Enflurane DB01110, Miconazole DB01069, Promethazine |
DrugCentrali | Q14003 |
Genetic variation databases
BioMutai | KCNC3 |
DMDMi | 212276500 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000054055 | 1 – 757 | Potassium voltage-gated channel subfamily C member 3Add BLAST | 757 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 320 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 336 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 483 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 625 | Omega-N-methylarginineBy similarity | 1 | |
Modified residuei | 686 | PhosphoserineBy similarity | 1 | |
Modified residuei | 691 | PhosphoserineBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
Glycoprotein, Methylation, PhosphoproteinProteomic databases
jPOSTi | Q14003 |
MassIVEi | Q14003 |
MaxQBi | Q14003 |
PaxDbi | Q14003 |
PeptideAtlasi | Q14003 |
PRIDEi | Q14003 |
ProteomicsDBi | 59785 |
PTM databases
GlyGeni | Q14003, 3 sites |
iPTMneti | Q14003 |
PhosphoSitePlusi | Q14003 |
Expressioni
Gene expression databases
Bgeei | ENSG00000131398, Expressed in cerebellar vermis and 175 other tissues |
ExpressionAtlasi | Q14003, baseline and differential |
Genevisiblei | Q14003, HS |
Organism-specific databases
HPAi | ENSG00000131398, Tissue enhanced (brain, thyroid gland) |
Interactioni
Subunit structurei
Homotetramer. Heterotetramer with KCNC1 (PubMed:23734863).
Interacts (via C-terminus) with HAX1 (PubMed:26997484).
Identified in a complex with ACTR3, a subunit of the Arp2/3 complex; this interaction is indirect and depends on the presence of HAX1 (PubMed:26997484). Interaction with HAX1 modulates channel gating (PubMed:26997484).
2 PublicationsProtein-protein interaction databases
BioGRIDi | 109950, 27 interactors |
IntActi | Q14003, 1 interactor |
STRINGi | 9606.ENSP00000434241 |
Miscellaneous databases
RNActi | Q14003, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 87 | DisorderedSequence analysisAdd BLAST | 87 | |
Regioni | 1 – 78 | Important for normal N-type inactivation1 PublicationAdd BLAST | 78 | |
Regioni | 210 – 232 | DisorderedSequence analysisAdd BLAST | 23 | |
Regioni | 556 – 613 | DisorderedSequence analysisAdd BLAST | 58 | |
Regioni | 682 – 746 | DisorderedSequence analysisAdd BLAST | 65 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 503 – 508 | Selectivity filterBy similarity | 6 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1 – 16 | Polar residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 20 – 63 | Pro residuesSequence analysisAdd BLAST | 44 | |
Compositional biasi | 565 – 604 | Pro residuesSequence analysisAdd BLAST | 40 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3713, Eukaryota |
GeneTreei | ENSGT00940000163131 |
InParanoidi | Q14003 |
OMAi | CPDKVDF |
OrthoDBi | 818306at2759 |
PhylomeDBi | Q14003 |
TreeFami | TF352511 |
Family and domain databases
Gene3Di | 1.20.120.350, 1 hit 3.30.710.10, 1 hit |
InterProi | View protein in InterPro IPR000210, BTB/POZ_dom IPR005821, Ion_trans_dom IPR003968, K_chnl_volt-dep_Kv IPR003974, K_chnl_volt-dep_Kv3 IPR005404, K_chnl_volt-dep_Kv3.3 IPR021105, K_chnl_volt-dep_Kv3_ID IPR011333, SKP1/BTB/POZ_sf IPR003131, T1-type_BTB IPR028325, VG_K_chnl IPR027359, Volt_channel_dom_sf |
PANTHERi | PTHR11537, PTHR11537, 1 hit |
Pfami | View protein in Pfam PF02214, BTB_2, 1 hit PF00520, Ion_trans, 1 hit PF11404, Potassium_chann, 1 hit |
PRINTSi | PR01582, KV33CHANNEL PR01491, KVCHANNEL PR01498, SHAWCHANNEL |
SMARTi | View protein in SMART SM00225, BTB, 1 hit |
SUPFAMi | SSF54695, SSF54695, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MLSSVCVSSF RGRQGASKQQ PAPPPQPPES PPPPPLPPQQ QQPAQPGPAA
60 70 80 90 100
SPAGPPAPRG PGDRRAEPCP GLPAAAMGRH GGGGGDSGKI VINVGGVRHE
110 120 130 140 150
TYRSTLRTLP GTRLAGLTEP EAAARFDYDP GADEFFFDRH PGVFAYVLNY
160 170 180 190 200
YRTGKLHCPA DVCGPLFEEE LGFWGIDETD VEACCWMTYR QHRDAEEALD
210 220 230 240 250
SFEAPDPAGA ANAANAAGAH DGGLDDEAGA GGGGLDGAGG ELKRLCFQDA
260 270 280 290 300
GGGAGGPPGG AGGAGGTWWR RWQPRVWALF EDPYSSRAAR YVAFASLFFI
310 320 330 340 350
LISITTFCLE THEGFIHISN KTVTQASPIP GAPPENITNV EVETEPFLTY
360 370 380 390 400
VEGVCVVWFT FEFLMRITFC PDKVEFLKSS LNIIDCVAIL PFYLEVGLSG
410 420 430 440 450
LSSKAAKDVL GFLRVVRFVR ILRIFKLTRH FVGLRVLGHT LRASTNEFLL
460 470 480 490 500
LIIFLALGVL IFATMIYYAE RIGADPDDIL GSNHTYFKNI PIGFWWAVVT
510 520 530 540 550
MTTLGYGDMY PKTWSGMLVG ALCALAGVLT IAMPVPVIVN NFGMYYSLAM
560 570 580 590 600
AKQKLPKKKN KHIPRPPQPG SPNYCKPDPP PPPPPHPHHG SGGISPPPPI
610 620 630 640 650
TPPSMGVTVA GAYPAGPHTH PGLLRGGAGG LGIMGLPPLP APGEPCPLAQ
660 670 680 690 700
EEVIEINRAD PRPNGDPAAA ALAHEDCPAI DQPAMSPEDK SPITPGSRGR
710 720 730 740 750
YSRDRACFLL TDYAPSPDGS IRKATGAPPL PPQDWRKPGP PSFLPDLNAN
AAAWISP
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE7ETH1 | E7ETH1_HUMAN | Potassium voltage-gated channel sub... | KCNC3 | 728 | Annotation score: | ||
A0A590UJ62 | A0A590UJ62_HUMAN | Potassium voltage-gated channel sub... | KCNC3 | 768 | Annotation score: | ||
E9PQY4 | E9PQY4_HUMAN | Potassium voltage-gated channel sub... | KCNC3 | 44 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_074192 | 41 | Q → H1 PublicationCorresponds to variant dbSNP:rs185017345EnsemblClinVar. | 1 | |
Natural variantiVAR_074193 | 63 | D → G2 PublicationsCorresponds to variant dbSNP:rs375912738EnsemblClinVar. | 1 | |
Natural variantiVAR_074194 | 129 | D → N in SCA13; unknown pathological significance; changes channel activity; shifts the voltage dependence of activation. 1 Publication | 1 | |
Natural variantiVAR_074195 | 263 | G → D Variant of uncertain significance; changes channel activity; activates more quickly and deactivates more slowly. 1 Publication | 1 | |
Natural variantiVAR_074196 | 366 | R → H in SCA13; unknown pathological significance; dominant negative that decreases channel activity; decreases protein abundance; decreases protein stability; decreases localization to the plasma membrane; no effect on tetramerization. 2 PublicationsCorresponds to variant dbSNP:rs769502387Ensembl. | 1 | |
Natural variantiVAR_029530 | 420 | R → H in SCA13; dominant negative that induces loss of channel activity; decreases protein abundance; decreases protein stability; decreases localization to the plasma membrane and alters the localization of the wild-type protein; impairs N-glycosylation; no effect on tetramerization. 6 PublicationsCorresponds to variant dbSNP:rs104894699EnsemblClinVar. | 1 | |
Natural variantiVAR_074197 | 423 | R → H in SCA13; dominant negative that reduces channel activity; alters gating; decreases protein abundance; decreases localization to the plasma membrane; no effect on tetramerization. 5 PublicationsCorresponds to variant dbSNP:rs797044872EnsemblClinVar. | 1 | |
Natural variantiVAR_029531 | 448 | F → L in SCA13; alters gating; slows channel closing; decreases protein abundance; no effect on localization to the plasma membrane; no effect on N-glycosylation; no effect on tetramerization. 4 PublicationsCorresponds to variant dbSNP:rs104894700EnsemblClinVar. | 1 | |
Natural variantiVAR_074198 | 477 | D → N in SCA13; unknown pathological significance; no effect on channel activity. 1 PublicationCorresponds to variant dbSNP:rs148033381EnsemblClinVar. | 1 | |
Natural variantiVAR_074199 | 535 | V → M in SCA13; changes channel activity; shifts the voltage dependence of activation. 1 Publication | 1 | |
Natural variantiVAR_074200 | 591 | S → G in SCA13; unknown pathological significance; reduces channel activity; shifts the voltage dependence of activation. 1 PublicationCorresponds to variant dbSNP:rs549394447EnsemblClinVar. | 1 | |
Natural variantiVAR_074201 | 643 | G → S in SCA13; unknown pathological significance; no effect on channel activity. 1 PublicationCorresponds to variant dbSNP:rs778523009Ensembl. | 1 | |
Natural variantiVAR_074202 | 645 | P → R in SCA13; unknown pathological significance; no effect on channel activity. 1 PublicationCorresponds to variant dbSNP:rs1460306526Ensembl. | 1 | |
Natural variantiVAR_074203 | 746 | D → N in SCA13; unknown pathological significance; no effect on channel activity. 1 PublicationCorresponds to variant dbSNP:rs958323371Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF055989 mRNA Translation: AAC24118.1 AC008655 Genomic DNA No translation available. Z11585 Genomic DNA Translation: CAA77671.1 |
CCDSi | CCDS12793.1 |
PIRi | S19552 |
RefSeqi | NP_004968.2, NM_004977.2 XP_006723266.1, XM_006723203.2 XP_011525228.1, XM_011526926.1 |
Genome annotation databases
Ensembli | ENST00000477616; ENSP00000434241; ENSG00000131398 |
GeneIDi | 3748 |
KEGGi | hsa:3748 |
MANE-Selecti | ENST00000477616.2; ENSP00000434241.1; NM_004977.3; NP_004968.2 |
UCSCi | uc002pru.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF055989 mRNA Translation: AAC24118.1 AC008655 Genomic DNA No translation available. Z11585 Genomic DNA Translation: CAA77671.1 |
CCDSi | CCDS12793.1 |
PIRi | S19552 |
RefSeqi | NP_004968.2, NM_004977.2 XP_006723266.1, XM_006723203.2 XP_011525228.1, XM_011526926.1 |
3D structure databases
SMRi | Q14003 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 109950, 27 interactors |
IntActi | Q14003, 1 interactor |
STRINGi | 9606.ENSP00000434241 |
Chemistry databases
ChEMBLi | CHEMBL2362996 |
DrugBanki | DB06637, Dalfampridine DB00228, Enflurane DB01110, Miconazole DB01069, Promethazine |
DrugCentrali | Q14003 |
Protein family/group databases
TCDBi | 1.A.1.2.13, the voltage-gated ion channel (vic) superfamily |
PTM databases
GlyGeni | Q14003, 3 sites |
iPTMneti | Q14003 |
PhosphoSitePlusi | Q14003 |
Genetic variation databases
BioMutai | KCNC3 |
DMDMi | 212276500 |
Proteomic databases
jPOSTi | Q14003 |
MassIVEi | Q14003 |
MaxQBi | Q14003 |
PaxDbi | Q14003 |
PeptideAtlasi | Q14003 |
PRIDEi | Q14003 |
ProteomicsDBi | 59785 |
Protocols and materials databases
ABCDi | Q14003, 1 sequenced antibody |
Antibodypediai | 18827, 305 antibodies from 30 providers |
DNASUi | 3748 |
Genome annotation databases
Ensembli | ENST00000477616; ENSP00000434241; ENSG00000131398 |
GeneIDi | 3748 |
KEGGi | hsa:3748 |
MANE-Selecti | ENST00000477616.2; ENSP00000434241.1; NM_004977.3; NP_004968.2 |
UCSCi | uc002pru.1, human |
Organism-specific databases
CTDi | 3748 |
DisGeNETi | 3748 |
GeneCardsi | KCNC3 |
GeneReviewsi | KCNC3 |
HGNCi | HGNC:6235, KCNC3 |
HPAi | ENSG00000131398, Tissue enhanced (brain, thyroid gland) |
MalaCardsi | KCNC3 |
MIMi | 176264, gene 605259, phenotype |
neXtProti | NX_Q14003 |
OpenTargetsi | ENSG00000131398 |
Orphaneti | 98768, Spinocerebellar ataxia type 13 |
PharmGKBi | PA30027 |
VEuPathDBi | HostDB:ENSG00000131398 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3713, Eukaryota |
GeneTreei | ENSGT00940000163131 |
InParanoidi | Q14003 |
OMAi | CPDKVDF |
OrthoDBi | 818306at2759 |
PhylomeDBi | Q14003 |
TreeFami | TF352511 |
Enzyme and pathway databases
PathwayCommonsi | Q14003 |
Reactomei | R-HSA-1296072, Voltage gated Potassium channels |
SignaLinki | Q14003 |
SIGNORi | Q14003 |
Miscellaneous databases
BioGRID-ORCSi | 3748, 121 hits in 1049 CRISPR screens |
ChiTaRSi | KCNC3, human |
GeneWikii | KCNC3 |
GenomeRNAii | 3748 |
Pharosi | Q14003, Tclin |
PROi | PR:Q14003 |
RNActi | Q14003, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000131398, Expressed in cerebellar vermis and 175 other tissues |
ExpressionAtlasi | Q14003, baseline and differential |
Genevisiblei | Q14003, HS |
Family and domain databases
Gene3Di | 1.20.120.350, 1 hit 3.30.710.10, 1 hit |
InterProi | View protein in InterPro IPR000210, BTB/POZ_dom IPR005821, Ion_trans_dom IPR003968, K_chnl_volt-dep_Kv IPR003974, K_chnl_volt-dep_Kv3 IPR005404, K_chnl_volt-dep_Kv3.3 IPR021105, K_chnl_volt-dep_Kv3_ID IPR011333, SKP1/BTB/POZ_sf IPR003131, T1-type_BTB IPR028325, VG_K_chnl IPR027359, Volt_channel_dom_sf |
PANTHERi | PTHR11537, PTHR11537, 1 hit |
Pfami | View protein in Pfam PF02214, BTB_2, 1 hit PF00520, Ion_trans, 1 hit PF11404, Potassium_chann, 1 hit |
PRINTSi | PR01582, KV33CHANNEL PR01491, KVCHANNEL PR01498, SHAWCHANNEL |
SMARTi | View protein in SMART SM00225, BTB, 1 hit |
SUPFAMi | SSF54695, SSF54695, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | KCNC3_HUMAN | |
Accessioni | Q14003Primary (citable) accession number: Q14003 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1998 |
Last sequence update: | November 4, 2008 | |
Last modified: | February 23, 2022 | |
This is version 191 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families