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UniProtKB - Q14002 (CEAM7_HUMAN)
Protein
Carcinoembryonic antigen-related cell adhesion molecule 7
Gene
CEACAM7
Organism
Homo sapiens (Human)
Status
Functioni
Enzyme and pathway databases
PathwayCommonsi | Q14002 |
Reactomei | R-HSA-163125, Post-translational modification: synthesis of GPI-anchored proteins |
SignaLinki | Q14002 |
Names & Taxonomyi
Protein namesi | Recommended name: Carcinoembryonic antigen-related cell adhesion molecule 7CuratedShort name: CEA cell adhesion molecule 7 Alternative name(s): Carcinoembryonic antigen CGM2 |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:1819, CEACAM7 |
MIMi | 619160, gene |
neXtProti | NX_Q14002 |
VEuPathDBi | HostDB:ENSG00000007306 |
Subcellular locationi
Plasma membrane
- Cell membrane Curated; GPI-anchor Curated
- Apical cell membrane 1 Publication
Note: Localized to the apical glycocalyx surface.1 Publication
Cytosol
- cytosol Source: HPA
Extracellular region or secreted
- extracellular region Source: Reactome
Plasma Membrane
- apical plasma membrane Source: UniProtKB
- plasma membrane Source: HPA
Other locations
- anchored component of membrane Source: UniProtKB-KW
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 1087 |
PharmGKBi | PA26363 |
Miscellaneous databases
Pharosi | Q14002, Tbio |
Genetic variation databases
BioMutai | CEACAM7 |
DMDMi | 5921734 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 35 | 1 PublicationAdd BLAST | 35 | |
ChainiPRO_0000014570 | 36 – 242 | Carcinoembryonic antigen-related cell adhesion molecule 7Add BLAST | 207 | |
PropeptideiPRO_0000014571 | 243 – 265 | Removed in mature formSequence analysisAdd BLAST | 23 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 57 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 85 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 105 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 112 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 168 ↔ 216 | PROSITE-ProRule annotation | ||
Glycosylationi | 174 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 183 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 198 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Lipidationi | 242 | GPI-anchor amidated serineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, Glycoprotein, GPI-anchor, LipoproteinProteomic databases
jPOSTi | Q14002 |
MassIVEi | Q14002 |
PaxDbi | Q14002 |
PeptideAtlasi | Q14002 |
PRIDEi | Q14002 |
ProteomicsDBi | 59783 [Q14002-1] 59784 [Q14002-2] |
PTM databases
GlyGeni | Q14002, 7 sites |
iPTMneti | Q14002 |
PhosphoSitePlusi | Q14002 |
Expressioni
Tissue specificityi
Expressed in columnar epithelial cells of the colon (at protein level) (PubMed:10436421). Strongly down-regulated in colonic adenocarcinomas.1 Publication
Gene expression databases
Bgeei | ENSG00000007306, Expressed in colon and 117 other tissues |
ExpressionAtlasi | Q14002, baseline and differential |
Genevisiblei | Q14002, HS |
Organism-specific databases
HPAi | ENSG00000007306, Tissue enriched (intestine) |
Interactioni
Subunit structurei
Homodimer.
1 PublicationProtein-protein interaction databases
BioGRIDi | 107513, 6 interactors |
IntActi | Q14002, 2 interactors |
STRINGi | 9606.ENSP00000006724 |
Miscellaneous databases
RNActi | Q14002, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
AlphaFoldDBi | Q14002 |
SMRi | Q14002 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 36 – 142 | Ig-like V-typeBy similarityAdd BLAST | 107 | |
Domaini | 146 – 233 | Ig-like C2-typePROSITE-ProRule annotationAdd BLAST | 88 |
Sequence similaritiesi
Keywords - Domaini
Immunoglobulin domain, Repeat, SignalPhylogenomic databases
eggNOGi | ENOG502RXPD, Eukaryota |
HOGENOMi | CLU_024555_4_0_1 |
InParanoidi | Q14002 |
OrthoDBi | 998214at2759 |
PhylomeDBi | Q14002 |
TreeFami | TF336859 |
Family and domain databases
Gene3Di | 2.60.40.10, 2 hits |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub IPR013106, Ig_V-set |
Pfami | View protein in Pfam PF07686, V-set, 1 hit |
SMARTi | View protein in SMART SM00409, IG, 2 hits |
SUPFAMi | SSF48726, SSF48726, 2 hits |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 2a (identifier: Q14002-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MGSPSACPYR VCIPWQGLLL TASLLTFWNL PNSAQTNIDV VPFNVAEGKE
60 70 80 90 100
VLLVVHNESQ NLYGYNWYKG ERVHANYRII GYVKNISQEN APGPAHNGRE
110 120 130 140 150
TIYPNGTLLI QNVTHNDAGI YTLHVIKENL VNEEVTRQFY VFSEPPKPSI
160 170 180 190 200
TSNNFNPVEN KDIVVLTCQP ETQNTTYLWW VNNQSLLVSP RLLLSTDNRT
210 220 230 240 250
LVLLSATKND IGPYECEIQN PVGASRSDPV TLNVRYESVQ ASSPDLSAGT
260
AVSIMIGVLA GMALI
Isoform 2b (identifier: Q14002-2) [UniParc]FASTAAdd to basket
The sequence of this isoform differs from the canonical sequence as follows:
143-235: Missing.
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0A0MTT6 | A0A0A0MTT6_HUMAN | Carcinoembryonic antigen-related ce... | CEACAM7 | 172 | Annotation score: | ||
A0A0G2JRA8 | A0A0G2JRA8_HUMAN | Carcinoembryonic antigen-related ce... | CEACAM7 | 30 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 40 | V → G in AAB62924 (Ref. 3) Curated | 1 | |
Sequence conflicti | 40 | V → G in AAB62925 (Ref. 3) Curated | 1 | |
Sequence conflicti | 71 | E → Q in AAB62924 (Ref. 3) Curated | 1 | |
Sequence conflicti | 71 | E → Q in AAB62925 (Ref. 3) Curated | 1 | |
Sequence conflicti | 235 | R → C in AAB62924 (Ref. 3) Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_024494 | 120 | I → F5 PublicationsCorresponds to variant dbSNP:rs8102488Ensembl. | 1 | |
Natural variantiVAR_059384 | 236 | Y → H. Corresponds to variant dbSNP:rs16975478Ensembl. | 1 | |
Natural variantiVAR_049848 | 263 | A → V. Corresponds to variant dbSNP:rs7259532Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_002488 | 143 – 235 | Missing in isoform 2b. CuratedAdd BLAST | 93 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L31792 mRNA Translation: AAA66186.1 X98311 mRNA Translation: CAA66955.1 AF006622 mRNA Translation: AAB62924.1 AF006623 mRNA Translation: AAB62925.1 AK292213 mRNA Translation: BAF84902.1 AK313108 mRNA Translation: BAG35930.1 AC005797 Genomic DNA Translation: AAC62825.1 AC005797 Genomic DNA Translation: AAC62826.1 BC121132 mRNA Translation: AAI21133.1 M22434 Genomic DNA Translation: AAA51966.1 |
CCDSi | CCDS12583.1 [Q14002-1] |
PIRi | A55811 |
RefSeqi | NP_001278414.1, NM_001291485.1 NP_008821.2, NM_006890.4 |
Genome annotation databases
Ensembli | ENST00000006724.7; ENSP00000006724.3; ENSG00000007306.15 ENST00000401731.6; ENSP00000385932.1; ENSG00000007306.15 ENST00000602225.1; ENSP00000469597.1; ENSG00000007306.15 [Q14002-2] |
GeneIDi | 1087 |
KEGGi | hsa:1087 |
MANE-Selecti | ENST00000401731.6; ENSP00000385932.1; NM_001291485.2; NP_001278414.1 |
UCSCi | uc002ori.2, human [Q14002-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L31792 mRNA Translation: AAA66186.1 X98311 mRNA Translation: CAA66955.1 AF006622 mRNA Translation: AAB62924.1 AF006623 mRNA Translation: AAB62925.1 AK292213 mRNA Translation: BAF84902.1 AK313108 mRNA Translation: BAG35930.1 AC005797 Genomic DNA Translation: AAC62825.1 AC005797 Genomic DNA Translation: AAC62826.1 BC121132 mRNA Translation: AAI21133.1 M22434 Genomic DNA Translation: AAA51966.1 |
CCDSi | CCDS12583.1 [Q14002-1] |
PIRi | A55811 |
RefSeqi | NP_001278414.1, NM_001291485.1 NP_008821.2, NM_006890.4 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4Y89 | X-ray | 1.47 | A/B/C/D | 34-142 | [»] | |
AlphaFoldDBi | Q14002 | |||||
SMRi | Q14002 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 107513, 6 interactors |
IntActi | Q14002, 2 interactors |
STRINGi | 9606.ENSP00000006724 |
PTM databases
GlyGeni | Q14002, 7 sites |
iPTMneti | Q14002 |
PhosphoSitePlusi | Q14002 |
Genetic variation databases
BioMutai | CEACAM7 |
DMDMi | 5921734 |
Proteomic databases
jPOSTi | Q14002 |
MassIVEi | Q14002 |
PaxDbi | Q14002 |
PeptideAtlasi | Q14002 |
PRIDEi | Q14002 |
ProteomicsDBi | 59783 [Q14002-1] 59784 [Q14002-2] |
Protocols and materials databases
Antibodypediai | 30805, 284 antibodies from 25 providers |
DNASUi | 1087 |
Genome annotation databases
Ensembli | ENST00000006724.7; ENSP00000006724.3; ENSG00000007306.15 ENST00000401731.6; ENSP00000385932.1; ENSG00000007306.15 ENST00000602225.1; ENSP00000469597.1; ENSG00000007306.15 [Q14002-2] |
GeneIDi | 1087 |
KEGGi | hsa:1087 |
MANE-Selecti | ENST00000401731.6; ENSP00000385932.1; NM_001291485.2; NP_001278414.1 |
UCSCi | uc002ori.2, human [Q14002-1] |
Organism-specific databases
CTDi | 1087 |
DisGeNETi | 1087 |
GeneCardsi | CEACAM7 |
HGNCi | HGNC:1819, CEACAM7 |
HPAi | ENSG00000007306, Tissue enriched (intestine) |
MIMi | 619160, gene |
neXtProti | NX_Q14002 |
PharmGKBi | PA26363 |
VEuPathDBi | HostDB:ENSG00000007306 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502RXPD, Eukaryota |
HOGENOMi | CLU_024555_4_0_1 |
InParanoidi | Q14002 |
OrthoDBi | 998214at2759 |
PhylomeDBi | Q14002 |
TreeFami | TF336859 |
Enzyme and pathway databases
PathwayCommonsi | Q14002 |
Reactomei | R-HSA-163125, Post-translational modification: synthesis of GPI-anchored proteins |
SignaLinki | Q14002 |
Miscellaneous databases
BioGRID-ORCSi | 1087, 8 hits in 1058 CRISPR screens |
ChiTaRSi | CEACAM7, human |
GeneWikii | CEACAM7 |
GenomeRNAii | 1087 |
Pharosi | Q14002, Tbio |
PROi | PR:Q14002 |
RNActi | Q14002, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000007306, Expressed in colon and 117 other tissues |
ExpressionAtlasi | Q14002, baseline and differential |
Genevisiblei | Q14002, HS |
Family and domain databases
Gene3Di | 2.60.40.10, 2 hits |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub IPR013106, Ig_V-set |
Pfami | View protein in Pfam PF07686, V-set, 1 hit |
SMARTi | View protein in SMART SM00409, IG, 2 hits |
SUPFAMi | SSF48726, SSF48726, 2 hits |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CEAM7_HUMAN | |
Accessioni | Q14002Primary (citable) accession number: Q14002 Secondary accession number(s): A8K848 Q9UPJ2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1999 |
Last sequence update: | February 23, 2022 | |
Last modified: | May 25, 2022 | |
This is version 171 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families