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Protein

Carcinoembryonic antigen-related cell adhesion molecule 7

Gene

CEACAM7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

ReactomeiR-HSA-163125 Post-translational modification: synthesis of GPI-anchored proteins

Names & Taxonomyi

Protein namesi
Recommended name:
Carcinoembryonic antigen-related cell adhesion molecule 7
Alternative name(s):
Carcinoembryonic antigen CGM2
Gene namesi
Name:CEACAM7
Synonyms:CGM2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000007306.14
HGNCiHGNC:1819 CEACAM7
neXtProtiNX_Q14002

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi1087
PharmGKBiPA26363

Polymorphism and mutation databases

BioMutaiCEACAM7
DMDMi5921734

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 351 PublicationAdd BLAST35
ChainiPRO_000001457036 – 242Carcinoembryonic antigen-related cell adhesion molecule 7Add BLAST207
PropeptideiPRO_0000014571243 – 265Removed in mature formSequence analysisAdd BLAST23

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi57N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi85N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi105N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi112N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi168 ↔ 216PROSITE-ProRule annotation
Glycosylationi174N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi183N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi198N-linked (GlcNAc...) asparagineSequence analysis1
Lipidationi242GPI-anchor amidated serineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiQ14002
PeptideAtlasiQ14002
PRIDEiQ14002
ProteomicsDBi59783
59784 [Q14002-2]

PTM databases

iPTMnetiQ14002
PhosphoSitePlusiQ14002

Expressioni

Tissue specificityi

Expressed in columnar epithelial cells of the colon (at protein level) (PubMed:10436421). Strongly down-regulated in colonic adenocarcinomas.1 Publication

Gene expression databases

BgeeiENSG00000007306 Expressed in 95 organ(s), highest expression level in colon
CleanExiHS_CEACAM7
ExpressionAtlasiQ14002 baseline and differential
GenevisibleiQ14002 HS

Organism-specific databases

HPAiHPA069621

Interactioni

Subunit structurei

Homodimer.1 Publication

Protein-protein interaction databases

BioGridi107513, 2 interactors
IntActiQ14002, 2 interactors
STRINGi9606.ENSP00000006724

Structurei

Secondary structure

1265
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ14002
SMRiQ14002
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini36 – 142Ig-like V-typeBy similarityAdd BLAST107
Domaini146 – 233Ig-like C2-typePROSITE-ProRule annotationAdd BLAST88

Sequence similaritiesi

Belongs to the immunoglobulin superfamily. CEA family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IFE1 Eukaryota
ENOG410YR1P LUCA
HOVERGENiHBG007922
InParanoidiQ14002
KOiK06499
OrthoDBiEOG091G0AMM
PhylomeDBiQ14002
TreeFamiTF336859

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF07686 V-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 2 hits
SUPFAMiSSF48726 SSF48726, 2 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 2a (identifier: Q14002-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGSPSACPYR VCIPWQGLLL TASLLTFWNL PNSAQTNIDV VPFNVAEGKE
60 70 80 90 100
VLLVVHNESQ NLYGYNWYKG ERVHANYRII GYVKNISQEN APGPAHNGRE
110 120 130 140 150
TIYPNGTLLI QNVTHNDAGF YTLHVIKENL VNEEVTRQFY VFSEPPKPSI
160 170 180 190 200
TSNNFNPVEN KDIVVLTCQP ETQNTTYLWW VNNQSLLVSP RLLLSTDNRT
210 220 230 240 250
LVLLSATKND IGPYECEIQN PVGASRSDPV TLNVRYESVQ ASSPDLSAGT
260
AVSIMIGVLA GMALI
Length:265
Mass (Da):29,379
Last modified:November 1, 1996 - v1
Checksum:iB6B836F66BD10D3B
GO
Isoform 2b (identifier: Q14002-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     143-235: Missing.

Show »
Length:172
Mass (Da):19,031
Checksum:iDE939FA24349681D
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MTT6A0A0A0MTT6_HUMAN
Carcinoembryonic antigen-related ce...
CEACAM7
172Annotation score:
A0A0G2JRA8A0A0G2JRA8_HUMAN
Carcinoembryonic antigen-related ce...
CEACAM7
30Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti40V → G in AAB62924 (Ref. 3) Curated1
Sequence conflicti40V → G in AAB62925 (Ref. 3) Curated1
Sequence conflicti71E → Q in AAB62924 (Ref. 3) Curated1
Sequence conflicti71E → Q in AAB62925 (Ref. 3) Curated1
Sequence conflicti235R → C in AAB62924 (Ref. 3) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_024494120F → I3 PublicationsCorresponds to variant dbSNP:rs8102488Ensembl.1
Natural variantiVAR_059384236Y → H. Corresponds to variant dbSNP:rs16975478Ensembl.1
Natural variantiVAR_049848263A → V. Corresponds to variant dbSNP:rs7259532Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_002488143 – 235Missing in isoform 2b. CuratedAdd BLAST93

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L31792 mRNA Translation: AAA66186.1
X98311 mRNA Translation: CAA66955.1
AF006622 mRNA Translation: AAB62924.1
AF006623 mRNA Translation: AAB62925.1
AK292213 mRNA Translation: BAF84902.1
AK313108 mRNA Translation: BAG35930.1
AC005797 Genomic DNA Translation: AAC62825.1
AC005797 Genomic DNA Translation: AAC62826.1
BC121132 mRNA Translation: AAI21133.1
M22434 Genomic DNA Translation: AAA51966.1
CCDSiCCDS12583.1 [Q14002-1]
PIRiA55811
RefSeqiNP_001278414.1, NM_001291485.1
NP_008821.2, NM_006890.4
UniGeneiHs.74466

Genome annotation databases

EnsembliENST00000006724; ENSP00000006724; ENSG00000007306
ENST00000401731; ENSP00000385932; ENSG00000007306
GeneIDi1087
KEGGihsa:1087
UCSCiuc002ori.2 human [Q14002-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L31792 mRNA Translation: AAA66186.1
X98311 mRNA Translation: CAA66955.1
AF006622 mRNA Translation: AAB62924.1
AF006623 mRNA Translation: AAB62925.1
AK292213 mRNA Translation: BAF84902.1
AK313108 mRNA Translation: BAG35930.1
AC005797 Genomic DNA Translation: AAC62825.1
AC005797 Genomic DNA Translation: AAC62826.1
BC121132 mRNA Translation: AAI21133.1
M22434 Genomic DNA Translation: AAA51966.1
CCDSiCCDS12583.1 [Q14002-1]
PIRiA55811
RefSeqiNP_001278414.1, NM_001291485.1
NP_008821.2, NM_006890.4
UniGeneiHs.74466

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4Y89X-ray1.47A/B/C/D34-142[»]
ProteinModelPortaliQ14002
SMRiQ14002
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107513, 2 interactors
IntActiQ14002, 2 interactors
STRINGi9606.ENSP00000006724

PTM databases

iPTMnetiQ14002
PhosphoSitePlusiQ14002

Polymorphism and mutation databases

BioMutaiCEACAM7
DMDMi5921734

Proteomic databases

PaxDbiQ14002
PeptideAtlasiQ14002
PRIDEiQ14002
ProteomicsDBi59783
59784 [Q14002-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000006724; ENSP00000006724; ENSG00000007306
ENST00000401731; ENSP00000385932; ENSG00000007306
GeneIDi1087
KEGGihsa:1087
UCSCiuc002ori.2 human [Q14002-1]

Organism-specific databases

CTDi1087
DisGeNETi1087
EuPathDBiHostDB:ENSG00000007306.14
GeneCardsiCEACAM7
HGNCiHGNC:1819 CEACAM7
HPAiHPA069621
neXtProtiNX_Q14002
PharmGKBiPA26363
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFE1 Eukaryota
ENOG410YR1P LUCA
HOVERGENiHBG007922
InParanoidiQ14002
KOiK06499
OrthoDBiEOG091G0AMM
PhylomeDBiQ14002
TreeFamiTF336859

Enzyme and pathway databases

ReactomeiR-HSA-163125 Post-translational modification: synthesis of GPI-anchored proteins

Miscellaneous databases

ChiTaRSiCEACAM7 human
GeneWikiiCEACAM7
GenomeRNAii1087
PROiPR:Q14002

Gene expression databases

BgeeiENSG00000007306 Expressed in 95 organ(s), highest expression level in colon
CleanExiHS_CEACAM7
ExpressionAtlasiQ14002 baseline and differential
GenevisibleiQ14002 HS

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF07686 V-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 2 hits
SUPFAMiSSF48726 SSF48726, 2 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCEAM7_HUMAN
AccessioniPrimary (citable) accession number: Q14002
Secondary accession number(s): A8K848
, O15148, O15149, Q0VAC1, Q13983, Q9UPJ2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1996
Last modified: September 12, 2018
This is version 154 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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