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Protein

Chemotaxis response regulator protein-glutamate methylesterase

Gene

cheB

Organism
Paraburkholderia xenovorans (strain LB400)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the modulation of the chemotaxis system; catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR.UniRule annotation

Catalytic activityi

Protein L-glutamate O5-methyl ester + H2O = protein L-glutamate + methanol.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei175UniRule annotation1
Active sitei201UniRule annotation1
Active sitei297UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processChemotaxis

Names & Taxonomyi

Protein namesi
Recommended name:
Chemotaxis response regulator protein-glutamate methylesteraseUniRule annotation (EC:3.1.1.61UniRule annotation)
Gene namesi
Name:cheBUniRule annotation
Ordered Locus Names:Bxeno_A4269
ORF Names:Bxe_A0124
OrganismiParaburkholderia xenovorans (strain LB400)
Taxonomic identifieri266265 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeParaburkholderia
Proteomesi
  • UP000001817 Componenti: Chromosome 1

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002642711 – 362Chemotaxis response regulator protein-glutamate methylesteraseAdd BLAST362

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei564-aspartylphosphateUniRule annotation1

Post-translational modificationi

Phosphorylated by CheA. Phosphorylation suppresses the inhibitory activity of the N-terminal domain.UniRule annotation

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi266265.Bxe_A0124

Structurei

3D structure databases

ProteinModelPortaliQ13SY2
SMRiQ13SY2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 122Response regulatoryPROSITE-ProRule annotationAdd BLAST118
Domaini163 – 355CheB-type methylesteraseUniRule annotationAdd BLAST193

Domaini

The N-terminal regulatory domain inhibits the activity of the C-terminal effector domain.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CMP Bacteria
COG2201 LUCA
HOGENOMiHOG000151423
KOiK03412
OMAiMLEMHRA
OrthoDBiPOG091H045J

Family and domain databases

CDDicd16432 CheB_Rec, 1 hit
cd00156 REC, 1 hit
Gene3Di3.40.50.180, 1 hit
HAMAPiMF_00099 CheB_methylest, 1 hit
InterProiView protein in InterPro
IPR035909 CheB_C
IPR011006 CheY-like_superfamily
IPR008248 Sig_transdc_resp-reg_CheB
IPR000673 Sig_transdc_resp-reg_Me-estase
IPR001789 Sig_transdc_resp-reg_receiver
PfamiView protein in Pfam
PF01339 CheB_methylest, 1 hit
PF00072 Response_reg, 1 hit
PIRSFiPIRSF000876 RR_chemtxs_CheB, 1 hit
SMARTiView protein in SMART
SM00448 REC, 1 hit
SUPFAMiSSF52172 SSF52172, 1 hit
SSF52738 SSF52738, 1 hit
PROSITEiView protein in PROSITE
PS50122 CHEB, 1 hit
PS50110 RESPONSE_REGULATORY, 1 hit

Sequencei

Sequence statusi: Complete.

Q13SY2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQKIKVLCVD DSALIRSLMT EIINGQPDMT VVATAPDPLV ARELIKQHNP
60 70 80 90 100
DVLTLDVEMP RMDGLDFLEK LMRLRPMPVV MVSSLTERGN EITLRALELG
110 120 130 140 150
AVDFVTKPKV GIRDGMLDYS EKLADKIRAA ARARVRQSAP VQHAAAHAAH
160 170 180 190 200
APVGAAPLFN NPLLSTEKLI IVGASTGGTE AIREVLVPLP PDAPAVLIAQ
210 220 230 240 250
HMPPGFTKSF AQRLNGLCRI TVKEAEHGER VLPGHAYIAP GHAHLLLARS
260 270 280 290 300
GANYIAHLSD EPPVNRHRPS VDVLFRSAAQ HAGKNAVGVI LTGMGRDGAA
310 320 330 340 350
GLLDMKKAGA YTLAQDEASC IVFGMPREAI ALGAADEIAS LPEMSRRVMA
360
RLSSMGDRVQ RV
Length:362
Mass (Da):38,843
Last modified:August 22, 2006 - v1
Checksum:i50F6149AADB202CB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000270 Genomic DNA Translation: ABE32807.1

Genome annotation databases

EnsemblBacteriaiABE32807; ABE32807; Bxe_A0124
KEGGibxb:DR64_2299
bxe:Bxe_A0124
PATRICifig|266265.5.peg.4488

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000270 Genomic DNA Translation: ABE32807.1

3D structure databases

ProteinModelPortaliQ13SY2
SMRiQ13SY2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi266265.Bxe_A0124

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABE32807; ABE32807; Bxe_A0124
KEGGibxb:DR64_2299
bxe:Bxe_A0124
PATRICifig|266265.5.peg.4488

Phylogenomic databases

eggNOGiENOG4105CMP Bacteria
COG2201 LUCA
HOGENOMiHOG000151423
KOiK03412
OMAiMLEMHRA
OrthoDBiPOG091H045J

Family and domain databases

CDDicd16432 CheB_Rec, 1 hit
cd00156 REC, 1 hit
Gene3Di3.40.50.180, 1 hit
HAMAPiMF_00099 CheB_methylest, 1 hit
InterProiView protein in InterPro
IPR035909 CheB_C
IPR011006 CheY-like_superfamily
IPR008248 Sig_transdc_resp-reg_CheB
IPR000673 Sig_transdc_resp-reg_Me-estase
IPR001789 Sig_transdc_resp-reg_receiver
PfamiView protein in Pfam
PF01339 CheB_methylest, 1 hit
PF00072 Response_reg, 1 hit
PIRSFiPIRSF000876 RR_chemtxs_CheB, 1 hit
SMARTiView protein in SMART
SM00448 REC, 1 hit
SUPFAMiSSF52172 SSF52172, 1 hit
SSF52738 SSF52738, 1 hit
PROSITEiView protein in PROSITE
PS50122 CHEB, 1 hit
PS50110 RESPONSE_REGULATORY, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCHEB_PARXL
AccessioniPrimary (citable) accession number: Q13SY2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: August 22, 2006
Last modified: October 10, 2018
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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