UniProtKB - Q13976 (KGP1_HUMAN)
cGMP-dependent protein kinase 1
PRKG1
Functioni
Serine/threonine protein kinase that acts as key mediator of the nitric oxide (NO)/cGMP signaling pathway. GMP binding activates PRKG1, which phosphorylates serines and threonines on many cellular proteins. Numerous protein targets for PRKG1 phosphorylation are implicated in modulating cellular calcium, but the contribution of each of these targets may vary substantially among cell types. Proteins that are phosphorylated by PRKG1 regulate platelet activation and adhesion, smooth muscle contraction, cardiac function, gene expression, feedback of the NO-signaling pathway, and other processes involved in several aspects of the CNS like axon guidance, hippocampal and cerebellar learning, circadian rhythm and nociception. Smooth muscle relaxation is mediated through lowering of intracellular free calcium, by desensitization of contractile proteins to calcium, and by decrease in the contractile state of smooth muscle or in platelet activation. Regulates intracellular calcium levels via several pathways: phosphorylates IRAG1 and inhibits IP3-induced Ca2+ release from intracellular stores, phosphorylation of KCNMA1 (BKCa) channels decreases intracellular Ca2+ levels, which leads to increased opening of this channel. PRKG1 phosphorylates the canonical transient receptor potential channel (TRPC) family which inactivates the associated inward calcium current. Another mode of action of NO/cGMP/PKGI signaling involves PKGI-mediated inactivation of the Ras homolog gene family member A (RhoA). Phosphorylation of RHOA by PRKG1 blocks the action of this protein in myriad processes: regulation of RHOA translocation; decreasing contraction; controlling vesicle trafficking, reduction of myosin light chain phosphorylation resulting in vasorelaxation. Activation of PRKG1 by NO signaling alters also gene expression in a number of tissues. In smooth muscle cells, increased cGMP and PRKG1 activity influence expression of smooth muscle-specific contractile proteins, levels of proteins in the NO/cGMP signaling pathway, down-regulation of the matrix proteins osteopontin and thrombospondin-1 to limit smooth muscle cell migration and phenotype. Regulates vasodilator-stimulated phosphoprotein (VASP) functions in platelets and smooth muscle.
8 PublicationsMiscellaneous
Catalytic activityi
Activity regulationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 282 | 3',5'-cGMP 2Combined sources2 Publications | 1 | |
Binding sitei | 336 | 3',5'-cAMP 2Combined sources1 Publication | 1 | |
Binding sitei | 336 | 3',5'-cGMP 2Combined sources2 Publications | 1 | |
Binding sitei | 390 | ATPPROSITE-ProRule annotation | 1 | |
Active sitei | 484 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 167 – 170 | 3',5'-cAMP 1Combined sources1 Publication | 4 | |
Nucleotide bindingi | 167 – 170 | 3',5'-cGMP 1Combined sources1 Publication | 4 | |
Nucleotide bindingi | 177 – 178 | 3',5'-cAMP 1Combined sources1 Publication | 2 | |
Nucleotide bindingi | 177 – 178 | 3',5'-cGMP 1Combined sources1 Publication | 2 | |
Nucleotide bindingi | 291 – 294 | 3',5'-cAMP 2Combined sources1 Publication | 4 | |
Nucleotide bindingi | 291 – 294 | 3',5'-cGMP 2Combined sources2 Publications | 4 | |
Nucleotide bindingi | 301 – 302 | 3',5'-cAMP 2Combined sources1 Publication | 2 | |
Nucleotide bindingi | 301 – 302 | 3',5'-cGMP 2Combined sources2 Publications | 2 | |
Nucleotide bindingi | 366 – 374 | ATPPROSITE-ProRule annotation | 9 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- calcium channel regulator activity Source: UniProtKB
- cGMP binding Source: UniProtKB-KW
- cGMP-dependent protein kinase activity Source: UniProtKB
- identical protein binding Source: IntAct
- protein kinase activity Source: BHF-UCL
GO - Biological processi
- actin cytoskeleton organization Source: ProtInc
- cGMP-mediated signaling Source: Ensembl
- dendrite development Source: Ensembl
- forebrain development Source: Ensembl
- negative regulation of platelet aggregation Source: UniProtKB
- negative regulation of vascular associated smooth muscle cell migration Source: BHF-UCL
- negative regulation of vascular associated smooth muscle cell proliferation Source: BHF-UCL
- neuron migration Source: Ensembl
- protein phosphorylation Source: ProtInc
- regulation of GTPase activity Source: UniProtKB
- relaxation of vascular associated smooth muscle Source: Ensembl
- signal transduction Source: ProtInc
Keywordsi
Molecular function | Allosteric enzyme, Kinase, Serine/threonine-protein kinase, Transferase |
Ligand | ATP-binding, cGMP, cGMP-binding, Nucleotide-binding |
Enzyme and pathway databases
BRENDAi | 2.7.11.12, 2681 |
PathwayCommonsi | Q13976 |
Reactomei | R-HSA-392517, Rap1 signalling [Q13976-1] R-HSA-4086398, Ca2+ pathway R-HSA-418457, cGMP effects [Q13976-1] |
SABIO-RKi | Q13976 |
SignaLinki | Q13976 |
SIGNORi | Q13976 |
Names & Taxonomyi
Protein namesi | Recommended name: cGMP-dependent protein kinase 1 (EC:2.7.11.12)Short name: cGK 1 Short name: cGK1 Alternative name(s): cGMP-dependent protein kinase I Short name: cGKI |
Gene namesi | Name:PRKG1 Synonyms:PRKG1B, PRKGR1A, PRKGR1B |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:9414, PRKG1 |
MIMi | 176894, gene |
neXtProti | NX_Q13976 |
VEuPathDBi | HostDB:ENSG00000185532 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm By similarity
Note: Colocalized with TRPC7 in the plasma membrane.By similarity
Cytosol
- cytosol Source: Reactome
Golgi apparatus
- Golgi apparatus Source: Ensembl
Plasma Membrane
- plasma membrane Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Involvement in diseasei
Aortic aneurysm, familial thoracic 8 (AAT8)1 Publication
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_070434 | 177 | R → Q in AAT8; impairs cGMP binding; the mutant protein is constitutively active. 1 PublicationCorresponds to variant dbSNP:rs397515330Ensembl. | 1 |
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 12 | L → A: Loss of binding to PPP1R12A. 1 Publication | 1 | |
Mutagenesisi | 19 | I → A: Loss of binding to PPP1R12A. 1 Publication | 1 | |
Mutagenesisi | 26 | L → P: Loss of binding to PPP1R12A. 1 Publication | 1 | |
Mutagenesisi | 33 | I → A: Loss of binding to PPP1R12A. 1 Publication | 1 | |
Mutagenesisi | 40 | L → A: Loss of binding to PPP1R12A. 1 Publication | 1 | |
Mutagenesisi | 281 | L → A: Reduces cGMP binding affinity. 1 Publication | 1 | |
Mutagenesisi | 282 | R → A: Reduces cGMP binding affinity. 1 Publication | 1 | |
Mutagenesisi | 302 | T → A: Reduces cGMP binding affinity. 1 Publication | 1 | |
Mutagenesisi | 336 | Y → A: Reduces cGMP binding affinity. 1 Publication | 1 |
Keywords - Diseasei
Aortic aneurysm, Disease variantOrganism-specific databases
DisGeNETi | 5592 |
MalaCardsi | PRKG1 |
MIMi | 615436, phenotype |
OpenTargetsi | ENSG00000185532 |
Orphaneti | 91387, Familial thoracic aortic aneurysm and aortic dissection |
PharmGKBi | PA33777 |
Miscellaneous databases
Pharosi | Q13976, Tchem |
Chemistry databases
ChEMBLi | CHEMBL4273 |
DrugCentrali | Q13976 |
GuidetoPHARMACOLOGYi | 1492 |
Genetic variation databases
BioMutai | PRKG1 |
DMDMi | 6225588 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000086115 | 2 – 671 | cGMP-dependent protein kinase 1Add BLAST | 670 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylserineCombined sources | 1 | |
Disulfide bondi | 43 | InterchainBy similarity | ||
Modified residuei | 59 | Phosphothreonine; by autocatalysisBy similarity | 1 | |
Modified residuei | 515 | PhosphothreonineBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, Disulfide bond, PhosphoproteinProteomic databases
EPDi | Q13976 |
jPOSTi | Q13976 |
MassIVEi | Q13976 |
MaxQBi | Q13976 |
PeptideAtlasi | Q13976 |
PRIDEi | Q13976 |
ProteomicsDBi | 59781 [Q13976-1] 59782 [Q13976-2] |
PTM databases
GlyGeni | Q13976, 1 site, 2 O-linked glycans (1 site) |
iPTMneti | Q13976 |
MetOSitei | Q13976 |
PhosphoSitePlusi | Q13976 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000185532, Expressed in biceps brachii and 214 other tissues |
ExpressionAtlasi | Q13976, baseline and differential |
Genevisiblei | Q13976, HS |
Organism-specific databases
HPAi | ENSG00000185532, Tissue enhanced (tongue) |
Interactioni
Subunit structurei
Isoform alpha: parallel homodimer or heterodimer and also heterotetramer.
Interacts directly with PPP1R12A. Non-covalent dimer of dimer of PRKG1-PRKG1 and PPP1R12A-PPP1R12A. This interaction targets PRKG1 to stress fibers to mediate smooth muscle cell relaxation and vasodilation in responses to rises in cGMP. Isoform beta: antiparallel homodimer. Part of cGMP kinase signaling complex at least composed of ACTA2/alpha-actin, CNN1/calponin H1, PLN/phospholamban, PRKG1 and ITPR1 (By similarity).
Interacts with IRAG1.
Forms a stable complex with ITPR1, IRAG1, and isoform beta of PRKG1.
Interacts with TRPC7 (via ankyrin repeat domain). Isoform alpha interacts with RGS2.
Interacts with GTF2I.
By similarity9 PublicationsBinary interactionsi
Q13976
PRKG1 - isoform Beta [Q13976-2]
GO - Molecular functioni
- identical protein binding Source: IntAct
Protein-protein interaction databases
BioGRIDi | 111578, 33 interactors |
DIPi | DIP-41118N DIP-46288N |
IntActi | Q13976, 16 interactors |
MINTi | Q13976 |
STRINGi | 9606.ENSP00000363092 |
Chemistry databases
BindingDBi | Q13976 |
Miscellaneous databases
RNActi | Q13976, protein |
Structurei
Secondary structure
3D structure databases
BMRBi | Q13976 |
SMRi | Q13976 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q13976 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 360 – 619 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 260 | |
Domaini | 620 – 671 | AGC-kinase C-terminalPROSITE-ProRule annotationAdd BLAST | 52 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 2 – 102 | Required for dimerizationAdd BLAST | 101 | |
Regioni | 9 – 44 | Leucine-zipperAdd BLAST | 36 | |
Regioni | 50 – 75 | Autoinhibitory domainBy similarityAdd BLAST | 26 | |
Regioni | 103 – 220 | cGMP-binding, high affinityAdd BLAST | 118 | |
Regioni | 221 – 341 | cGMP-binding, low affinityAdd BLAST | 121 | |
Regioni | 635 – 671 | DisorderedSequence analysisAdd BLAST | 37 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 2 – 59 | 1 PublicationAdd BLAST | 58 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 651 – 671 | Acidic residuesSequence analysisAdd BLAST | 21 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG0614, Eukaryota |
GeneTreei | ENSGT00940000154704 |
HOGENOMi | CLU_000288_73_2_1 |
InParanoidi | Q13976 |
OMAi | ESCLADC |
OrthoDBi | 401933at2759 |
PhylomeDBi | Q13976 |
TreeFami | TF313261 |
Family and domain databases
CDDi | cd00038, CAP_ED, 2 hits cd05572, STKc_cGK, 1 hit |
Gene3Di | 2.60.120.10, 2 hits |
InterProi | View protein in InterPro IPR000961, AGC-kinase_C IPR002374, cGMP_dep_kinase IPR018490, cNMP-bd-like IPR018488, cNMP-bd_CS IPR000595, cNMP-bd_dom IPR011009, Kinase-like_dom_sf IPR031831, PKcGMP_CC IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR014710, RmlC-like_jellyroll IPR008271, Ser/Thr_kinase_AS IPR035014, STKc_cGK |
Pfami | View protein in Pfam PF00027, cNMP_binding, 2 hits PF16808, PKcGMP_CC, 1 hit PF00069, Pkinase, 1 hit |
PIRSFi | PIRSF000559, cGMP-dep_kinase, 1 hit |
PRINTSi | PR00104, CGMPKINASE |
SMARTi | View protein in SMART SM00100, cNMP, 2 hits SM00133, S_TK_X, 1 hit SM00220, S_TKc, 1 hit |
SUPFAMi | SSF51206, SSF51206, 2 hits SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS51285, AGC_KINASE_CTER, 1 hit PS00888, CNMP_BINDING_1, 2 hits PS00889, CNMP_BINDING_2, 2 hits PS50042, CNMP_BINDING_3, 2 hits PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSELEEDFAK ILMLKEERIK ELEKRLSEKE EEIQELKRKL HKCQSVLPVP
60 70 80 90 100
STHIGPRTTR AQGISAEPQT YRSFHDLRQA FRKFTKSERS KDLIKEAILD
110 120 130 140 150
NDFMKNLELS QIQEIVDCMY PVEYGKDSCI IKEGDVGSLV YVMEDGKVEV
160 170 180 190 200
TKEGVKLCTM GPGKVFGELA ILYNCTRTAT VKTLVNVKLW AIDRQCFQTI
210 220 230 240 250
MMRTGLIKHT EYMEFLKSVP TFQSLPEEIL SKLADVLEET HYENGEYIIR
260 270 280 290 300
QGARGDTFFI ISKGTVNVTR EDSPSEDPVF LRTLGKGDWF GEKALQGEDV
310 320 330 340 350
RTANVIAAEA VTCLVIDRDS FKHLIGGLDD VSNKAYEDAE AKAKYEAEAA
360 370 380 390 400
FFANLKLSDF NIIDTLGVGG FGRVELVQLK SEESKTFAMK ILKKRHIVDT
410 420 430 440 450
RQQEHIRSEK QIMQGAHSDF IVRLYRTFKD SKYLYMLMEA CLGGELWTIL
460 470 480 490 500
RDRGSFEDST TRFYTACVVE AFAYLHSKGI IYRDLKPENL ILDHRGYAKL
510 520 530 540 550
VDFGFAKKIG FGKKTWTFCG TPEYVAPEII LNKGHDISAD YWSLGILMYE
560 570 580 590 600
LLTGSPPFSG PDPMKTYNII LRGIDMIEFP KKIAKNAANL IKKLCRDNPS
610 620 630 640 650
ERLGNLKNGV KDIQKHKWFE GFNWEGLRKG TLTPPIIPSV ASPTDTSNFD
660 670
SFPEDNDEPP PDDNSGWDID F
The sequence of this isoform differs from the canonical sequence as follows:
1-89: MSELEEDFAK...AFRKFTKSER → MGTLRDLQYA...TLPFYPKSPQ
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A5F9ZGW0 | A0A5F9ZGW0_HUMAN | cGMP-dependent protein kinase | PRKG1 | 382 | Annotation score: | ||
B1ALS0 | B1ALS0_HUMAN | cGMP-dependent protein kinase 1 | PRKG1 | 312 | Annotation score: | ||
A0A2R8Y507 | A0A2R8Y507_HUMAN | cGMP-dependent protein kinase 1 | PRKG1 | 323 | Annotation score: | ||
A0A2R8YE50 | A0A2R8YE50_HUMAN | cGMP-dependent protein kinase 1 | PRKG1 | 260 | Annotation score: | ||
A0A2R8YH74 | A0A2R8YH74_HUMAN | cGMP-dependent protein kinase 1 | PRKG1 | 287 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_070434 | 177 | R → Q in AAT8; impairs cGMP binding; the mutant protein is constitutively active. 1 PublicationCorresponds to variant dbSNP:rs397515330Ensembl. | 1 | |
Natural variantiVAR_046773 | 249 | I → V1 PublicationCorresponds to variant dbSNP:rs56082459Ensembl. | 1 | |
Natural variantiVAR_051632 | 267 | N → S1 PublicationCorresponds to variant dbSNP:rs34997494Ensembl. | 1 | |
Natural variantiVAR_070435 | 474 | Y → F1 PublicationCorresponds to variant dbSNP:rs149710600Ensembl. | 1 | |
Natural variantiVAR_070436 | 666 | G → A1 PublicationCorresponds to variant dbSNP:rs750949508Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_038714 | 1 – 89 | MSELE…TKSER → MGTLRDLQYALQEKIEELRQ RDALIDELELELDQKDELIQ KLQNELDKYRSVIRPATQQA QKQSASTLQGEPRTKRQAIS AEPTAFDIQDLSHVTLPFYP KSPQ in isoform Beta. 3 PublicationsAdd BLAST | 89 | |
Alternative sequenceiVSP_055541 | 1 – 15 | MSELE…ILMLK → MEKQNMFLHGSYILR in isoform 3. 1 PublicationAdd BLAST | 15 | |
Alternative sequenceiVSP_055542 | 16 – 297 | Missing in isoform 3. 1 PublicationAdd BLAST | 282 |
Sequence databases
Genome annotation databases
Ensembli | ENST00000373980; ENSP00000363092; ENSG00000185532 [Q13976-2] ENST00000401604; ENSP00000384200; ENSG00000185532 |
GeneIDi | 5592 |
KEGGi | hsa:5592 |
MANE-Selecti | ENST00000373980.11; ENSP00000363092.5; NM_006258.4; NP_006249.1 [Q13976-2] |
UCSCi | uc001jjo.4, human [Q13976-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1ZXA | NMR | - | A/B | 2-59 | [»] | |
3NMD | X-ray | 2.27 | A/B/C/D/E | 4-47 | [»] | |
3OCP | X-ray | 2.49 | A/B | 84-212 | [»] | |
3OD0 | X-ray | 2.90 | A/B | 84-212 | [»] | |
3OGJ | X-ray | 2.75 | A/B/C/D | 84-212 | [»] | |
4KU7 | X-ray | 1.65 | A | 204-354 | [»] | |
4KU8 | X-ray | 1.99 | A/B/C | 204-354 | [»] | |
4QX5 | X-ray | 1.32 | A | 204-354 | [»] | |
4QXK | Other | 2.20 | A | 204-354 | [»] | |
4R4L | X-ray | 2.25 | A/B/C | 2-48 | [»] | |
4R4M | X-ray | 1.92 | A/B/C | 2-48 | [»] | |
4Z07 | X-ray | 2.50 | A/C/E | 84-336 | [»] | |
5J48 | X-ray | 1.49 | A/B | 204-336 | [»] | |
5JAX | X-ray | 1.49 | A | 204-336 | [»] | |
5JD7 | X-ray | 1.75 | A | 204-336 | [»] | |
5L0N | X-ray | 1.28 | A | 204-336 | [»] | |
6BDL | X-ray | 1.96 | A/B | 327-671 | [»] | |
6BG2 | X-ray | 1.83 | A/B/C/D | 327-671 | [»] | |
6C0T | X-ray | 1.98 | A | 327-671 | [»] | |
BMRBi | Q13976 | |||||
SMRi | Q13976 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 111578, 33 interactors |
DIPi | DIP-41118N DIP-46288N |
IntActi | Q13976, 16 interactors |
MINTi | Q13976 |
STRINGi | 9606.ENSP00000363092 |
Chemistry databases
BindingDBi | Q13976 |
ChEMBLi | CHEMBL4273 |
DrugCentrali | Q13976 |
GuidetoPHARMACOLOGYi | 1492 |
PTM databases
GlyGeni | Q13976, 1 site, 2 O-linked glycans (1 site) |
iPTMneti | Q13976 |
MetOSitei | Q13976 |
PhosphoSitePlusi | Q13976 |
Genetic variation databases
BioMutai | PRKG1 |
DMDMi | 6225588 |
Proteomic databases
EPDi | Q13976 |
jPOSTi | Q13976 |
MassIVEi | Q13976 |
MaxQBi | Q13976 |
PeptideAtlasi | Q13976 |
PRIDEi | Q13976 |
ProteomicsDBi | 59781 [Q13976-1] 59782 [Q13976-2] |
Protocols and materials databases
Antibodypediai | 2108, 336 antibodies from 38 providers |
DNASUi | 5592 |
Genome annotation databases
Ensembli | ENST00000373980; ENSP00000363092; ENSG00000185532 [Q13976-2] ENST00000401604; ENSP00000384200; ENSG00000185532 |
GeneIDi | 5592 |
KEGGi | hsa:5592 |
MANE-Selecti | ENST00000373980.11; ENSP00000363092.5; NM_006258.4; NP_006249.1 [Q13976-2] |
UCSCi | uc001jjo.4, human [Q13976-1] |
Organism-specific databases
CTDi | 5592 |
DisGeNETi | 5592 |
GeneCardsi | PRKG1 |
HGNCi | HGNC:9414, PRKG1 |
HPAi | ENSG00000185532, Tissue enhanced (tongue) |
MalaCardsi | PRKG1 |
MIMi | 176894, gene 615436, phenotype |
neXtProti | NX_Q13976 |
OpenTargetsi | ENSG00000185532 |
Orphaneti | 91387, Familial thoracic aortic aneurysm and aortic dissection |
PharmGKBi | PA33777 |
VEuPathDBi | HostDB:ENSG00000185532 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0614, Eukaryota |
GeneTreei | ENSGT00940000154704 |
HOGENOMi | CLU_000288_73_2_1 |
InParanoidi | Q13976 |
OMAi | ESCLADC |
OrthoDBi | 401933at2759 |
PhylomeDBi | Q13976 |
TreeFami | TF313261 |
Enzyme and pathway databases
BRENDAi | 2.7.11.12, 2681 |
PathwayCommonsi | Q13976 |
Reactomei | R-HSA-392517, Rap1 signalling [Q13976-1] R-HSA-4086398, Ca2+ pathway R-HSA-418457, cGMP effects [Q13976-1] |
SABIO-RKi | Q13976 |
SignaLinki | Q13976 |
SIGNORi | Q13976 |
Miscellaneous databases
BioGRID-ORCSi | 5592, 11 hits in 1073 CRISPR screens |
ChiTaRSi | PRKG1, human |
EvolutionaryTracei | Q13976 |
GeneWikii | PRKG1 |
GenomeRNAii | 5592 |
Pharosi | Q13976, Tchem |
PROi | PR:Q13976 |
RNActi | Q13976, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000185532, Expressed in biceps brachii and 214 other tissues |
ExpressionAtlasi | Q13976, baseline and differential |
Genevisiblei | Q13976, HS |
Family and domain databases
CDDi | cd00038, CAP_ED, 2 hits cd05572, STKc_cGK, 1 hit |
Gene3Di | 2.60.120.10, 2 hits |
InterProi | View protein in InterPro IPR000961, AGC-kinase_C IPR002374, cGMP_dep_kinase IPR018490, cNMP-bd-like IPR018488, cNMP-bd_CS IPR000595, cNMP-bd_dom IPR011009, Kinase-like_dom_sf IPR031831, PKcGMP_CC IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR014710, RmlC-like_jellyroll IPR008271, Ser/Thr_kinase_AS IPR035014, STKc_cGK |
Pfami | View protein in Pfam PF00027, cNMP_binding, 2 hits PF16808, PKcGMP_CC, 1 hit PF00069, Pkinase, 1 hit |
PIRSFi | PIRSF000559, cGMP-dep_kinase, 1 hit |
PRINTSi | PR00104, CGMPKINASE |
SMARTi | View protein in SMART SM00100, cNMP, 2 hits SM00133, S_TK_X, 1 hit SM00220, S_TKc, 1 hit |
SUPFAMi | SSF51206, SSF51206, 2 hits SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS51285, AGC_KINASE_CTER, 1 hit PS00888, CNMP_BINDING_1, 2 hits PS00889, CNMP_BINDING_2, 2 hits PS50042, CNMP_BINDING_3, 2 hits PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | KGP1_HUMAN | |
Accessioni | Q13976Primary (citable) accession number: Q13976 Secondary accession number(s): A5YM56 Q6P5T7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 30, 2000 |
Last sequence update: | January 23, 2007 | |
Last modified: | February 23, 2022 | |
This is version 210 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human and mouse protein kinases
Human and mouse protein kinases: classification and index - Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families