RASGRF1

Functionⁱ

Promotes the exchange of Ras-bound GDP by GTP.1 Publication

GO - Molecular functionⁱ

glutamate receptor binding Source: Ensembl
guanyl-nucleotide exchange factor activity
Source: ProtInc
Traceable author statementⁱ
- 1379731
Ras guanyl-nucleotide exchange factor activity
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 27856453
Rho guanyl-nucleotide exchange factor activity Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

activation of GTPase activity Source: HGNC
cell proliferation Source: Ensembl
long-term memory
Source: UniProtKB
Non-traceable author statementⁱ
- 10918068
MAPK cascade Source: Reactome
neuron projection development Source: HGNC
positive regulation of GTPase activity Source: HGNC
positive regulation of Ras protein signal transduction Source: UniProtKB
regulation of neuronal synaptic plasticity Source: Ensembl
regulation of NMDA receptor activity Source: Ensembl
regulation of Rac protein signal transduction Source: HGNC
regulation of Ras protein signal transduction Source: HGNC
regulation of Rho protein signal transduction Source: InterPro
regulation of synaptic plasticity Source: UniProtKB
response to endoplasmic reticulum stress
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 27856453
signal transduction
Source: ProtInc
Traceable author statementⁱ
- 7684828
small GTPase mediated signal transduction Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Guanine-nucleotide releasing factor

Molecular function

Guanine-nucleotide releasing factor

Enzyme and pathway databases

Reactomeⁱ	R-HSA-442982 Ras activation upon Ca2+ influx through NMDA receptor R-HSA-5673001 RAF/MAP kinase cascade
SIGNORⁱ	Q13972

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Ras-specific guanine nucleotide-releasing factor 1 Short name: Ras-GRF1 Alternative name(s): Guanine nucleotide-releasing protein Short name: GNRP Ras-specific nucleotide exchange factor CDC25
Gene namesⁱ	Name:RASGRF1 Synonyms:CDC25, GNRP, GRF1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 15

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000058335.15
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:9875 RASGRF1
MIMⁱ	606600 gene
neXtProtⁱ	NX_Q13972

Subcellular locationⁱ

GO - Cellular component

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	5923
Open Targets More...OpenTargetsⁱ	ENSG00000058335
PharmGKBⁱ	PA34238

Chemistry databases

ChEMBLⁱ	CHEMBL5468

ChEMBLⁱ

CHEMBL5468

Polymorphism and mutation databases

DMDMⁱ	13124259

DMDMⁱ

13124259

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000068880	1 – 1273	Ras-specific guanine nucleotide-releasing factor 1Add BLAST		1273

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	577	Phosphoserine; by PLK2By similarity	1
Modified residueⁱ	626	Phosphoserine; by PLK2By similarity	1
Modified residueⁱ	758	PhosphoserineBy similarity	1
Modified residueⁱ	779	Phosphoserine; by PLK2By similarity	1
Modified residueⁱ	800	Phosphoserine; by PLK2By similarity	1

Post-translational modificationⁱ

Phosphorylated by PLK2, leading to ubiquitination and degradation by the proteasome.By similarity

Ubiquitinated and degraded following phosphorylation by PLK2.By similarity

Phosphorylated by SRC and LCK. Phosphorylation by LCK increases its capacity to stimulate the GDP/GTP exchange on Ras, whereas its phosphorylation by SRC seems not to have an effect on stimulation activity.1 Publication

Keywords - PTMⁱ

Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbⁱ	Q13972
PeptideAtlas More...PeptideAtlasⁱ	Q13972
PRIDEⁱ	Q13972
ProteomicsDBⁱ	59779 59780 [Q13972-2]

PTM databases

iPTMnetⁱ	Q13972
PhosphoSitePlusⁱ	Q13972

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000058335 Expressed in 112 organ(s), highest expression level in C1 segment of cervical spinal cord
CleanExⁱ	HS_RASGRF1
Genevisibleⁱ	Q13972 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB010413 HPA041965

HPAⁱ

CAB010413
HPA041965

Interactionⁱ

Subunit structureⁱ

Homooligomer and heterooligomer with RASGRF2. Interacts with USP8, thereby regulating its stability (By similarity).By similarity

GO - Molecular functionⁱ

glutamate receptor binding Source: Ensembl
guanyl-nucleotide exchange factor activity
Source: ProtInc
Traceable author statementⁱ
- 1379731
Ras guanyl-nucleotide exchange factor activity
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 27856453
Rho guanyl-nucleotide exchange factor activity Source: InterPro

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	111858, 11 interactors
IntActⁱ	Q13972, 7 interactors
Molecular INTeraction database More...MINTⁱ	Q13972
STRINGⁱ	9606.ENSP00000405963

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q13972
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	22 – 129	PH 1PROSITE-ProRule annotationAdd BLAST	108
Domainⁱ	204 – 229	IQPROSITE-ProRule annotationAdd BLAST	26
Domainⁱ	240 – 426	DHPROSITE-ProRule annotationAdd BLAST	187
Domainⁱ	467 – 584	PH 2PROSITE-ProRule annotationAdd BLAST	118
Domainⁱ	644 – 761	N-terminal Ras-GEFPROSITE-ProRule annotationAdd BLAST	118
Domainⁱ	1038 – 1270	Ras-GEFPROSITE-ProRule annotationAdd BLAST	233

Domainⁱ

The DH (DBL-homology) domain mediates interaction with RASGRF2.

Keywords - Domainⁱ

Repeat

Phylogenomic databases

eggNOGⁱ	ENOG410IQ6Q Eukaryota ENOG410XPWA LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00910000143985
HOGENOMⁱ	HOG000046000
HOVERGENⁱ	HBG005208
InParanoidⁱ	Q13972
KEGG Orthology (KO) More...KOⁱ	K04349
OMAⁱ	DPGDNQI
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G09V6
PhylomeDBⁱ	Q13972
TreeFamⁱ	TF317296

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00155 RasGEF, 1 hit cd06224 REM, 1 hit cd00160 RhoGEF, 1 hit
Gene3Dⁱ	1.10.840.10, 1 hit 1.20.900.10, 1 hit 2.30.29.30, 2 hits
InterProⁱ	View protein in InterPro IPR035899 DBL_dom_sf IPR000219 DH-domain IPR001331 GDS_CDC24_CS IPR000048 IQ_motif_EF-hand-BS IPR011993 PH-like_dom_sf IPR001849 PH_domain IPR000651 Ras-like_Gua-exchang_fac_N IPR019804 Ras_G-nucl-exch_fac_CS IPR023578 Ras_GEF_dom_sf IPR001895 RASGEF_cat_dom IPR036964 RASGEF_cat_dom_sf IPR030745 RasGRF1
PANTHERⁱ	PTHR23113:SF193 PTHR23113:SF193, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00169 PH, 2 hits PF00617 RasGEF, 1 hit PF00618 RasGEF_N, 1 hit PF00621 RhoGEF, 1 hit
SMARTⁱ	View protein in SMART SM00233 PH, 2 hits SM00147 RasGEF, 1 hit SM00229 RasGEFN, 2 hits SM00325 RhoGEF, 1 hit
SUPFAMⁱ	SSF48065 SSF48065, 1 hit SSF48366 SSF48366, 2 hits
PROSITEⁱ	View protein in PROSITE PS00741 DH_1, 1 hit PS50010 DH_2, 1 hit PS50096 IQ, 1 hit PS50003 PH_DOMAIN, 2 hits PS00720 RASGEF, 1 hit PS50009 RASGEF_CAT, 1 hit PS50212 RASGEF_NTER, 1 hit

Sequences (3)ⁱ

Sequence statusⁱ: Complete.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform 1 (identifier: Q13972-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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        10         20         30         40         50
MQKGIRLNDG HVASLGLLAR KDGTRKGYLS KRSSDNTKWQ TKWFALLQNL 
        60         70         80         90        100
LFYFESDSSS RPSGLYLLEG CVCDRAPSPK PALSAKEPLE KQHYFTVNFS 
       110        120        130        140        150
HENQKALELR TEDAKDCDEW VAAIAHASYR TLATEHEALM QKYLHLLQIV 
       160        170        180        190        200
ETEKTVAKQL RQQIEDGEIE IERLKAEITS LLKDNERIQS TQTVAPNDED 
       210        220        230        240        250
SDIKKIKKVQ SFLRGWLCRR KWKTIIQDYI RSPHADSMRK RNQVVFSMLE 
       260        270        280        290        300
AEAEYVQQLH ILVNNFLRPL RMAASSKKPP ITHDDVSSIF LNSETIMFLH 
       310        320        330        340        350
QIFYQGLKAR ISSWPTLVLA DLFDILLPML NIYQEFVRNH QYSLQILAHC 
       360        370        380        390        400
KQNRDFDKLL KHYEAKPDCE ERTLETFLTY PMFQIPRYIL TLHELLAHTP 
       410        420        430        440        450
HEHVERNSLD YAKSKLEELS RIMHDEVSET ENIRKNLAIE RMIIEGCEIL 
       460        470        480        490        500
LDTSQTFVRQ GSLIQVPMSE KGKITRGRLG SLSLKKEGER QCFLFSKHLI 
       510        520        530        540        550
ICTRGSGGKL HLTKNGVISL IDCTLLEEPE STEEEAKGSG QDIDHLDFKI 
       560        570        580        590        600
GVEPKDSPPF TVILVASSRQ EKAAWTSDIS QCVDNIRCNG LMMNAFEENS 
       610        620        630        640        650
KVTVPQMIKR TREGTREAEM SRSDASLYCD DVDIRFSKTM NSCKVLQIRY 
       660        670        680        690        700
ASVERLLERL TDLRFLSIDF LNTFLHSYRV FTTAIVVLDK LITIYKKPIS 
       710        720        730        740        750
AIPARWLRSL ELLFASGQNN KLLYGEPPKS PRATRKFSSP PPLSITKTSS 
       760        770        780        790        800
PSRRRKLSLN IPIITGGKAL DLAALSCNSN GYTSMYSAMS PFSKATLDTS 
       810        820        830        840        850
KLYVSSSFTN KIPDEGDTTP EKPEDPSALS KQSSEVSMRE ESDIDQNQSD 
       860        870        880        890        900
DGDTETSPTK SPTTPKSVKN KNSSEFPLFS YNNGVVMTSC RELDNNRSAL 
       910        920        930        940        950
SAASAFAIAT AGANEGTPNK EKYRRMSLAS AGFPPDQRNG DKEFVIRRAA 
       960        970        980        990       1000
TNRVLNVLRH WVSKHSQDFE TNDELKCKVI GFLEEVMHDP ELLTQERKAA 
      1010       1020       1030       1040       1050
ANIIRTLTQE DPGDNQITLE EITQMAEGVK AEPFENHSAL EIAEQLTLLD 
      1060       1070       1080       1090       1100
HLVFKKIPYE EFFGQGWMKL EKNERTPYIM KTTKHFNDIS NLIASEIIRN 
      1110       1120       1130       1140       1150
EDINARVSAI EKWVAVADIC RCLHNYNAVL EITSSMNRSA IFRLKKTWLK 
      1160       1170       1180       1190       1200
VSKQTKALID KLQKLVSSEG RFKNLREALK NCDPPCVPYL GMYLTDLAFI 
      1210       1220       1230       1240       1250
EEGTPNYTED GLVNFSKMRM ISHIIREIRQ FQQTAYKIEH QAKVTQYLLD 
      1260       1270 
QSFVMDEESL YESSLRIEPK LPT

Length:1,273

Mass (Da):145,234

Last modified:April 16, 2014 - v2

Checksum:ⁱB629AEAFDC7E500A

GO

Isoform 2 (identifier: Q13972-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-784: Missing.

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        10         20         30         40         50
MYSAMSPFSK ATLDTSKLYV SSSFTNKIPD EGDTTPEKPE DPSALSKQSS 
        60         70         80         90        100
EVSMREESDI DQNQSDDGDT ETSPTKSPTT PKSVKNKNSS EFPLFSYNNG 
       110        120        130        140        150
VVMTSCRELD NNRSALSAAS AFAIATAGAN EGTPNKEKYR RMSLASAGFP 
       160        170        180        190        200
PDQRNGDKEF VIRRAATNRV LNVLRHWVSK HSQDFETNDE LKCKVIGFLE 
       210        220        230        240        250
EVMHDPELLT QERKAAANII RTLTQEDPGD NQITLEEITQ MAEGVKAEPF 
       260        270        280        290        300
ENHSALEIAE QLTLLDHLVF KKIPYEEFFG QGWMKLEKNE RTPYIMKTTK 
       310        320        330        340        350
HFNDISNLIA SEIIRNEDIN ARVSAIEKWV AVADICRCLH NYNAVLEITS 
       360        370        380        390        400
SMNRSAIFRL KKTWLKVSKQ TKALIDKLQK LVSSEGRFKN LREALKNCDP 
       410        420        430        440        450
PCVPYLGMYL TDLAFIEEGT PNYTEDGLVN FSKMRMISHI IREIRQFQQT 
       460        470        480 
AYKIEHQAKV TQYLLDQSFV MDEESLYESS LRIEPKLPT

Show »

Length:489

Mass (Da):55,489

Checksum:ⁱDDF1EDAD9793F3EF

GO

Isoform 3 (identifier: Q13972-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
610-622: Missing.
705-707: Missing.

« Hide

        10         20         30         40         50
MQKGIRLNDG HVASLGLLAR KDGTRKGYLS KRSSDNTKWQ TKWFALLQNL 
        60         70         80         90        100
LFYFESDSSS RPSGLYLLEG CVCDRAPSPK PALSAKEPLE KQHYFTVNFS 
       110        120        130        140        150
HENQKALELR TEDAKDCDEW VAAIAHASYR TLATEHEALM QKYLHLLQIV 
       160        170        180        190        200
ETEKTVAKQL RQQIEDGEIE IERLKAEITS LLKDNERIQS TQTVAPNDED 
       210        220        230        240        250
SDIKKIKKVQ SFLRGWLCRR KWKTIIQDYI RSPHADSMRK RNQVVFSMLE 
       260        270        280        290        300
AEAEYVQQLH ILVNNFLRPL RMAASSKKPP ITHDDVSSIF LNSETIMFLH 
       310        320        330        340        350
QIFYQGLKAR ISSWPTLVLA DLFDILLPML NIYQEFVRNH QYSLQILAHC 
       360        370        380        390        400
KQNRDFDKLL KHYEAKPDCE ERTLETFLTY PMFQIPRYIL TLHELLAHTP 
       410        420        430        440        450
HEHVERNSLD YAKSKLEELS RIMHDEVSET ENIRKNLAIE RMIIEGCEIL 
       460        470        480        490        500
LDTSQTFVRQ GSLIQVPMSE KGKITRGRLG SLSLKKEGER QCFLFSKHLI 
       510        520        530        540        550
ICTRGSGGKL HLTKNGVISL IDCTLLEEPE STEEEAKGSG QDIDHLDFKI 
       560        570        580        590        600
GVEPKDSPPF TVILVASSRQ EKAAWTSDIS QCVDNIRCNG LMMNAFEENS 
       610        620        630        640        650
KVTVPQMIKS DASLYCDDVD IRFSKTMNSC KVLQIRYASV ERLLERLTDL 
       660        670        680        690        700
RFLSIDFLNT FLHSYRVFTT AIVVLDKLIT IYKKPISAIP ARSLELLFAS 
       710        720        730        740        750
GQNNKLLYGE PPKSPRATRK FSSPPPLSIT KTSSPSRRRK LSLNIPIITG 
       760        770        780        790        800
GKALDLAALS CNSNGYTSMY SAMSPFSKAT LDTSKLYVSS SFTNKIPDEG 
       810        820        830        840        850
DTTPEKPEDP SALSKQSSEV SMREESDIDQ NQSDDGDTET SPTKSPTTPK 
       860        870        880        890        900
SVKNKNSSEF PLFSYNNGVV MTSCRELDNN RSALSAASAF AIATAGANEG 
       910        920        930        940        950
TPNKEKYRRM SLASAGFPPD QRNGDKEFVI RRAATNRVLN VLRHWVSKHS 
       960        970        980        990       1000
QDFETNDELK CKVIGFLEEV MHDPELLTQE RKAAANIIRT LTQEDPGDNQ 
      1010       1020       1030       1040       1050
ITLEEITQMA EGVKAEPFEN HSALEIAEQL TLLDHLVFKK IPYEEFFGQG 
      1060       1070       1080       1090       1100
WMKLEKNERT PYIMKTTKHF NDISNLIASE IIRNEDINAR VSAIEKWVAV 
      1110       1120       1130       1140       1150
ADICRCLHNY NAVLEITSSM NRSAIFRLKK TWLKVSKQTK ALIDKLQKLV 
      1160       1170       1180       1190       1200
SSEGRFKNLR EALKNCDPPC VPYLGMYLTD LAFIEEGTPN YTEDGLVNFS 
      1210       1220       1230       1240       1250
KMRMISHIIR EIRQFQQTAY KIEHQAKVTQ YLLDQSFVMD EESLYESSLR 

IEPKLPT

Show »

Length:1,257

Mass (Da):143,218

Checksum:ⁱ097E066E032DFFDB

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	1053	V → A in M91815 (PubMed:1379731).Curated	1
Sequence conflictⁱ	1111	E → G in M91815 (PubMed:1379731).Curated	1
Sequence conflictⁱ	1134	S → C in M91815 (PubMed:1379731).Curated	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_012032	1 – 784	Missing in isoform 2. 1 PublicationAdd BLAST	784
Alternative sequenceⁱVSP_054072	610 – 622	Missing in isoform 3. 1 PublicationAdd BLAST	13
Alternative sequenceⁱVSP_054073	705 – 707	Missing in isoform 3. 1 Publication	3

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L26584 mRNA Translation: AAA58417.1 S62035 mRNA Translation: AAB26881.1 AC011944 Genomic DNA No translation available. AC104231 Genomic DNA No translation available. CH471136 Genomic DNA Translation: EAW99141.1 AK226101 mRNA No translation available. M91815 mRNA No translation available.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS10309.1 [Q13972-1] CCDS42065.1 [Q13972-2] CCDS45320.1 [Q13972-3]
PIRⁱ	A38985
NCBI Reference Sequences More...RefSeqⁱ	NP_002882.3, NM_002891.4 [Q13972-1] NP_722522.1, NM_153815.2 [Q13972-2]
UniGeneⁱ	Hs.459035

Genome annotation databases

Ensemblⁱ	ENST00000394745; ENSP00000378228; ENSG00000058335 [Q13972-2] ENST00000419573; ENSP00000405963; ENSG00000058335 [Q13972-1] ENST00000558480; ENSP00000452781; ENSG00000058335 [Q13972-3]
GeneIDⁱ	5923
KEGGⁱ	hsa:5923
UCSC genome browser More...UCSCⁱ	uc002beo.4 human [Q13972-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Protein	Similar proteins		Species	Score	Length	Source
Q13972	Isoform 2 of Ras-specific guanine nucleotide-releasing factor 1		HUMAN		489	UniRef90_Q13972
Ras protein specific guanine nucleotide releasing factor 1		OTOGA		1275
Ras protein specific guanine nucleotide releasing factor 1		AILME		1275
Ras protein specific guanine nucleotide releasing factor 1		HORSE		1274
RASGRF1 isoform 1		PANTR		1273
+203

Protein	Similar proteins		Species	Score	Length	Source
Q13972	Isoform 2 of Ras-specific guanine nucleotide-releasing factor 1		HUMAN		489	UniRef50_Q13972
Ras protein specific guanine nucleotide releasing factor 1		OTOGA		1275
Ras protein specific guanine nucleotide releasing factor 1		AILME		1275
Ras protein specific guanine nucleotide releasing factor 1		HORSE		1274
Ras protein specific guanine nucleotide releasing factor 1		RHIBE		1273
+229

Cross-referencesⁱ

Web resourcesⁱ

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L26584 mRNA Translation: AAA58417.1 S62035 mRNA Translation: AAB26881.1 AC011944 Genomic DNA No translation available. AC104231 Genomic DNA No translation available. CH471136 Genomic DNA Translation: EAW99141.1 AK226101 mRNA No translation available. M91815 mRNA No translation available.
CCDSⁱ	CCDS10309.1 [Q13972-1] CCDS42065.1 [Q13972-2] CCDS45320.1 [Q13972-3]
PIRⁱ	A38985
RefSeqⁱ	NP_002882.3, NM_002891.4 [Q13972-1] NP_722522.1, NM_153815.2 [Q13972-2]
UniGeneⁱ	Hs.459035

3D structure databases

ProteinModelPortalⁱ	Q13972
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	111858, 11 interactors
IntActⁱ	Q13972, 7 interactors
MINTⁱ	Q13972
STRINGⁱ	9606.ENSP00000405963

Chemistry databases

ChEMBLⁱ	CHEMBL5468

ChEMBLⁱ

CHEMBL5468

PTM databases

iPTMnetⁱ	Q13972
PhosphoSitePlusⁱ	Q13972

Polymorphism and mutation databases

DMDMⁱ	13124259

DMDMⁱ

13124259

Proteomic databases

PaxDbⁱ	Q13972
PeptideAtlasⁱ	Q13972
PRIDEⁱ	Q13972
ProteomicsDBⁱ	59779 59780 [Q13972-2]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000394745; ENSP00000378228; ENSG00000058335 [Q13972-2] ENST00000419573; ENSP00000405963; ENSG00000058335 [Q13972-1] ENST00000558480; ENSP00000452781; ENSG00000058335 [Q13972-3]
GeneIDⁱ	5923
KEGGⁱ	hsa:5923
UCSCⁱ	uc002beo.4 human [Q13972-1]

Organism-specific databases

CTDⁱ	5923
DisGeNETⁱ	5923
EuPathDBⁱ	HostDB:ENSG00000058335.15
GeneCardsⁱ	RASGRF1
H-InvDBⁱ	HIX0023098
HGNCⁱ	HGNC:9875 RASGRF1
HPAⁱ	CAB010413 HPA041965
MIMⁱ	606600 gene
neXtProtⁱ	NX_Q13972
OpenTargetsⁱ	ENSG00000058335
PharmGKBⁱ	PA34238
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IQ6Q Eukaryota ENOG410XPWA LUCA
GeneTreeⁱ	ENSGT00910000143985
HOGENOMⁱ	HOG000046000
HOVERGENⁱ	HBG005208
InParanoidⁱ	Q13972
KOⁱ	K04349
OMAⁱ	DPGDNQI
OrthoDBⁱ	EOG091G09V6
PhylomeDBⁱ	Q13972
TreeFamⁱ	TF317296

Enzyme and pathway databases

Reactomeⁱ	R-HSA-442982 Ras activation upon Ca2+ influx through NMDA receptor R-HSA-5673001 RAF/MAP kinase cascade
SIGNORⁱ	Q13972

Miscellaneous databases

ChiTaRSⁱ	RASGRF1 human
GenomeRNAiⁱ	5923
Protein Ontology More...PROⁱ	PR:Q13972
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000058335 Expressed in 112 organ(s), highest expression level in C1 segment of cervical spinal cord
CleanExⁱ	HS_RASGRF1
Genevisibleⁱ	Q13972 HS

Family and domain databases

CDDⁱ	cd00155 RasGEF, 1 hit cd06224 REM, 1 hit cd00160 RhoGEF, 1 hit
Gene3Dⁱ	1.10.840.10, 1 hit 1.20.900.10, 1 hit 2.30.29.30, 2 hits
InterProⁱ	View protein in InterPro IPR035899 DBL_dom_sf IPR000219 DH-domain IPR001331 GDS_CDC24_CS IPR000048 IQ_motif_EF-hand-BS IPR011993 PH-like_dom_sf IPR001849 PH_domain IPR000651 Ras-like_Gua-exchang_fac_N IPR019804 Ras_G-nucl-exch_fac_CS IPR023578 Ras_GEF_dom_sf IPR001895 RASGEF_cat_dom IPR036964 RASGEF_cat_dom_sf IPR030745 RasGRF1
PANTHERⁱ	PTHR23113:SF193 PTHR23113:SF193, 1 hit
Pfamⁱ	View protein in Pfam PF00169 PH, 2 hits PF00617 RasGEF, 1 hit PF00618 RasGEF_N, 1 hit PF00621 RhoGEF, 1 hit
SMARTⁱ	View protein in SMART SM00233 PH, 2 hits SM00147 RasGEF, 1 hit SM00229 RasGEFN, 2 hits SM00325 RhoGEF, 1 hit
SUPFAMⁱ	SSF48065 SSF48065, 1 hit SSF48366 SSF48366, 2 hits
PROSITEⁱ	View protein in PROSITE PS00741 DH_1, 1 hit PS50010 DH_2, 1 hit PS50096 IQ, 1 hit PS50003 PH_DOMAIN, 2 hits PS00720 RASGEF, 1 hit PS50009 RASGEF_CAT, 1 hit PS50212 RASGEF_NTER, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	RGRF1_HUMAN
Accessionⁱ	Q13972Primary (citable) accession number: Q13972 Secondary accession number(s): F8VPA5 , H0YKF2, J3KQP9, Q16027
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 21, 2001
	Last sequence update:	April 16, 2014
	Last modified:	September 12, 2018
	This is version 180 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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UniProtKB - Q13972 (RGRF1_HUMAN)

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Ras-specific guanine nucleotide-releasing factor 1

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Functionⁱ

GO - Molecular functionⁱ

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Expressionⁱ

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Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

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Miscellaneousⁱ

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