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UniProtKB - Q13972 (RGRF1_HUMAN)

Entry version 201 (23 Feb 2022)
Sequence version 2 (16 Apr 2014)
Previous versions | rss
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Protein

Ras-specific guanine nucleotide-releasing factor 1

Gene

RASGRF1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Promotes the exchange of Ras-bound GDP by GTP.

1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGuanine-nucleotide releasing factor

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q13972

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-442982, Ras activation upon Ca2+ influx through NMDA receptor
R-HSA-5673001, RAF/MAP kinase cascade

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q13972

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q13972

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ras-specific guanine nucleotide-releasing factor 1
Short name:
Ras-GRF1
Alternative name(s):
Guanine nucleotide-releasing protein
Short name:
GNRP
Ras-specific nucleotide exchange factor CDC25
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RASGRF1
Synonyms:CDC25, GNRP, GRF1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:9875, RASGRF1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		606600, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q13972

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000058335

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		5923

Open Targets

More...OpenTargetsi		ENSG00000058335

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA34238

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q13972, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL5468

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		RASGRF1

Domain mapping of disease mutations (DMDM)

More...DMDMi		13124259

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000688801 – 1273Ras-specific guanine nucleotide-releasing factor 1Add BLAST1273

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei577Phosphoserine; by PLK2By similarity1
Modified residuei626Phosphoserine; by PLK2By similarity1
Modified residuei758PhosphoserineBy similarity1
Modified residuei779Phosphoserine; by PLK2By similarity1
Modified residuei800Phosphoserine; by PLK2By similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by PLK2, leading to ubiquitination and degradation by the proteasome.By similarity
Ubiquitinated and degraded following phosphorylation by PLK2.By similarity
Phosphorylated by SRC and LCK. Phosphorylation by LCK increases its capacity to stimulate the GDP/GTP exchange on Ras, whereas its phosphorylation by SRC seems not to have an effect on stimulation activity.1 Publication

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q13972

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q13972

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q13972

PeptideAtlas

More...PeptideAtlasi		Q13972

PRoteomics IDEntifications database

More...PRIDEi		Q13972

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		28264
59779 [Q13972-1]
59780 [Q13972-2]

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		2067, 1 N-Linked glycan (1 site)

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q13972, 1 site, 2 N-linked glycans (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q13972

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q13972

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000058335, Expressed in C1 segment of cervical spinal cord and 133 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q13972, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000058335, Group enriched (brain, lung, retina)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homooligomer and heterooligomer with RASGRF2.

Interacts with USP8, thereby regulating its stability (By similarity).

By similarity

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		111858, 13 interactors

Protein interaction database and analysis system

More...IntActi		Q13972, 8 interactors

Molecular INTeraction database

More...MINTi		Q13972

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000405963

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q13972, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q13972

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini22 – 129PH 1PROSITE-ProRule annotationAdd BLAST108
Domaini204 – 229IQPROSITE-ProRule annotationAdd BLAST26
Domaini240 – 426DHPROSITE-ProRule annotationAdd BLAST187
Domaini467 – 584PH 2PROSITE-ProRule annotationAdd BLAST118
Domaini644 – 761N-terminal Ras-GEFPROSITE-ProRule annotationAdd BLAST118
Domaini1038 – 1270Ras-GEFPROSITE-ProRule annotationAdd BLAST233

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni724 – 754DisorderedSequence analysisAdd BLAST31
Regioni809 – 874DisorderedSequence analysisAdd BLAST66

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi737 – 754Polar residuesSequence analysisAdd BLAST18
Compositional biasi851 – 874Polar residuesSequence analysisAdd BLAST24

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The DH (DBL-homology) domain mediates interaction with RASGRF2.

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3417, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000157599

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_003405_0_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q13972

Identification of Orthologs from Complete Genome Data

More...OMAi		HHYFTVN

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q13972

TreeFam database of animal gene trees

More...TreeFami		TF317296

Family and domain databases

Conserved Domains Database

More...CDDi		cd00155, RasGEF, 1 hit
cd06224, REM, 1 hit
cd00160, RhoGEF, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.840.10, 1 hit
1.20.900.10, 1 hit
2.30.29.30, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR035899, DBL_dom_sf
IPR000219, DH-domain
IPR001331, GDS_CDC24_CS
IPR000048, IQ_motif_EF-hand-BS
IPR011993, PH-like_dom_sf
IPR001849, PH_domain
IPR008937, Ras-like_GEF
IPR000651, Ras-like_Gua-exchang_fac_N
IPR019804, Ras_G-nucl-exch_fac_CS
IPR023578, Ras_GEF_dom_sf
IPR001895, RASGEF_cat_dom
IPR036964, RASGEF_cat_dom_sf
IPR030745, RasGRF1

The PANTHER Classification System

More...PANTHERi		PTHR23113, PTHR23113, 1 hit
PTHR23113:SF193, PTHR23113:SF193, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00169, PH, 2 hits
PF00617, RasGEF, 1 hit
PF00618, RasGEF_N, 1 hit
PF00621, RhoGEF, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00233, PH, 2 hits
SM00147, RasGEF, 1 hit
SM00229, RasGEFN, 2 hits
SM00325, RhoGEF, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48065, SSF48065, 1 hit
SSF48366, SSF48366, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00741, DH_1, 1 hit
PS50010, DH_2, 1 hit
PS50096, IQ, 1 hit
PS50003, PH_DOMAIN, 2 hits
PS00720, RASGEF, 1 hit
PS50009, RASGEF_CAT, 1 hit
PS50212, RASGEF_NTER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q13972-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MQKGIRLNDG HVASLGLLAR KDGTRKGYLS KRSSDNTKWQ TKWFALLQNL 
        60         70         80         90        100
LFYFESDSSS RPSGLYLLEG CVCDRAPSPK PALSAKEPLE KQHYFTVNFS 
       110        120        130        140        150
HENQKALELR TEDAKDCDEW VAAIAHASYR TLATEHEALM QKYLHLLQIV 
       160        170        180        190        200
ETEKTVAKQL RQQIEDGEIE IERLKAEITS LLKDNERIQS TQTVAPNDED 
       210        220        230        240        250
SDIKKIKKVQ SFLRGWLCRR KWKTIIQDYI RSPHADSMRK RNQVVFSMLE 
       260        270        280        290        300
AEAEYVQQLH ILVNNFLRPL RMAASSKKPP ITHDDVSSIF LNSETIMFLH 
       310        320        330        340        350
QIFYQGLKAR ISSWPTLVLA DLFDILLPML NIYQEFVRNH QYSLQILAHC 
       360        370        380        390        400
KQNRDFDKLL KHYEAKPDCE ERTLETFLTY PMFQIPRYIL TLHELLAHTP 
       410        420        430        440        450
HEHVERNSLD YAKSKLEELS RIMHDEVSET ENIRKNLAIE RMIIEGCEIL 
       460        470        480        490        500
LDTSQTFVRQ GSLIQVPMSE KGKITRGRLG SLSLKKEGER QCFLFSKHLI 
       510        520        530        540        550
ICTRGSGGKL HLTKNGVISL IDCTLLEEPE STEEEAKGSG QDIDHLDFKI 
       560        570        580        590        600
GVEPKDSPPF TVILVASSRQ EKAAWTSDIS QCVDNIRCNG LMMNAFEENS 
       610        620        630        640        650
KVTVPQMIKR TREGTREAEM SRSDASLYCD DVDIRFSKTM NSCKVLQIRY 
       660        670        680        690        700
ASVERLLERL TDLRFLSIDF LNTFLHSYRV FTTAIVVLDK LITIYKKPIS 
       710        720        730        740        750
AIPARWLRSL ELLFASGQNN KLLYGEPPKS PRATRKFSSP PPLSITKTSS 
       760        770        780        790        800
PSRRRKLSLN IPIITGGKAL DLAALSCNSN GYTSMYSAMS PFSKATLDTS 
       810        820        830        840        850
KLYVSSSFTN KIPDEGDTTP EKPEDPSALS KQSSEVSMRE ESDIDQNQSD 
       860        870        880        890        900
DGDTETSPTK SPTTPKSVKN KNSSEFPLFS YNNGVVMTSC RELDNNRSAL 
       910        920        930        940        950
SAASAFAIAT AGANEGTPNK EKYRRMSLAS AGFPPDQRNG DKEFVIRRAA 
       960        970        980        990       1000
TNRVLNVLRH WVSKHSQDFE TNDELKCKVI GFLEEVMHDP ELLTQERKAA 
      1010       1020       1030       1040       1050
ANIIRTLTQE DPGDNQITLE EITQMAEGVK AEPFENHSAL EIAEQLTLLD 
      1060       1070       1080       1090       1100
HLVFKKIPYE EFFGQGWMKL EKNERTPYIM KTTKHFNDIS NLIASEIIRN 
      1110       1120       1130       1140       1150
EDINARVSAI EKWVAVADIC RCLHNYNAVL EITSSMNRSA IFRLKKTWLK 
      1160       1170       1180       1190       1200
VSKQTKALID KLQKLVSSEG RFKNLREALK NCDPPCVPYL GMYLTDLAFI 
      1210       1220       1230       1240       1250
EEGTPNYTED GLVNFSKMRM ISHIIREIRQ FQQTAYKIEH QAKVTQYLLD 
      1260       1270 
QSFVMDEESL YESSLRIEPK LPT
Length:1,273
Mass (Da):145,234
Last modified:April 16, 2014 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB629AEAFDC7E500A
GO
Isoform 2 (identifier: Q13972-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-784: Missing.

Show »
Length:489
Mass (Da):55,489
Checksum:iDDF1EDAD9793F3EF
GO
Isoform 3 (identifier: Q13972-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     610-622: Missing.
     705-707: Missing.

Show »
Length:1,257
Mass (Da):143,218
Checksum:i097E066E032DFFDB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1053V → A in M91815 (PubMed:1379731).Curated1
Sequence conflicti1111E → G in M91815 (PubMed:1379731).Curated1
Sequence conflicti1134S → C in M91815 (PubMed:1379731).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0120321 – 784Missing in isoform 2. 1 PublicationAdd BLAST784
Alternative sequenceiVSP_054072610 – 622Missing in isoform 3. 1 PublicationAdd BLAST13
Alternative sequenceiVSP_054073705 – 707Missing in isoform 3. 1 Publication3

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
L26584 mRNA Translation: AAA58417.1
S62035 mRNA Translation: AAB26881.1
AC011944 Genomic DNA No translation available.
AC104231 Genomic DNA No translation available.
CH471136 Genomic DNA Translation: EAW99141.1
AK226101 mRNA No translation available.
M91815 mRNA No translation available.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS10309.1 [Q13972-1]
CCDS42065.1 [Q13972-2]
CCDS45320.1 [Q13972-3]

Protein sequence database of the Protein Information Resource

More...PIRi		A38985

NCBI Reference Sequences

More...RefSeqi		NP_002882.3, NM_002891.4 [Q13972-1]
NP_722522.1, NM_153815.2 [Q13972-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000394745; ENSP00000378228; ENSG00000058335 [Q13972-2]
ENST00000419573; ENSP00000405963; ENSG00000058335
ENST00000558480; ENSP00000452781; ENSG00000058335 [Q13972-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		5923

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:5923

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000558480.7; ENSP00000452781.2; NM_001145648.3; NP_001139120.1 [Q13972-3]

UCSC genome browser

More...UCSCi		uc002beo.4, human [Q13972-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L26584 mRNA Translation: AAA58417.1
S62035 mRNA Translation: AAB26881.1
AC011944 Genomic DNA No translation available.
AC104231 Genomic DNA No translation available.
CH471136 Genomic DNA Translation: EAW99141.1
AK226101 mRNA No translation available.
M91815 mRNA No translation available.
CCDSiCCDS10309.1 [Q13972-1]
CCDS42065.1 [Q13972-2]
CCDS45320.1 [Q13972-3]
PIRiA38985
RefSeqiNP_002882.3, NM_002891.4 [Q13972-1]
NP_722522.1, NM_153815.2 [Q13972-2]

3D structure databases

SMRiQ13972
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi111858, 13 interactors
IntActiQ13972, 8 interactors
MINTiQ13972
STRINGi9606.ENSP00000405963

Chemistry databases

ChEMBLiCHEMBL5468

PTM databases

GlyConnecti2067, 1 N-Linked glycan (1 site)
GlyGeniQ13972, 1 site, 2 N-linked glycans (1 site)
iPTMnetiQ13972
PhosphoSitePlusiQ13972

Genetic variation databases

BioMutaiRASGRF1
DMDMi13124259

Proteomic databases

jPOSTiQ13972
MassIVEiQ13972
PaxDbiQ13972
PeptideAtlasiQ13972
PRIDEiQ13972
ProteomicsDBi28264
59779 [Q13972-1]
59780 [Q13972-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		4170, 335 antibodies from 33 providers

The DNASU plasmid repository

More...DNASUi		5923

Genome annotation databases

EnsembliENST00000394745; ENSP00000378228; ENSG00000058335 [Q13972-2]
ENST00000419573; ENSP00000405963; ENSG00000058335
ENST00000558480; ENSP00000452781; ENSG00000058335 [Q13972-3]
GeneIDi5923
KEGGihsa:5923
MANE-SelectiENST00000558480.7; ENSP00000452781.2; NM_001145648.3; NP_001139120.1 [Q13972-3]
UCSCiuc002beo.4, human [Q13972-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		5923
DisGeNETi5923

GeneCards: human genes, protein and diseases

More...GeneCardsi		RASGRF1
HGNCiHGNC:9875, RASGRF1
HPAiENSG00000058335, Group enriched (brain, lung, retina)
MIMi606600, gene
neXtProtiNX_Q13972
OpenTargetsiENSG00000058335
PharmGKBiPA34238
VEuPathDBiHostDB:ENSG00000058335

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3417, Eukaryota
GeneTreeiENSGT00940000157599
HOGENOMiCLU_003405_0_1_1
InParanoidiQ13972
OMAiHHYFTVN
PhylomeDBiQ13972
TreeFamiTF317296

Enzyme and pathway databases

PathwayCommonsiQ13972
ReactomeiR-HSA-442982, Ras activation upon Ca2+ influx through NMDA receptor
R-HSA-5673001, RAF/MAP kinase cascade
SignaLinkiQ13972
SIGNORiQ13972

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		5923, 4 hits in 1042 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		RASGRF1, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		5923
PharosiQ13972, Tbio

Protein Ontology

More...PROi		PR:Q13972
RNActiQ13972, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000058335, Expressed in C1 segment of cervical spinal cord and 133 other tissues
GenevisibleiQ13972, HS

Family and domain databases

CDDicd00155, RasGEF, 1 hit
cd06224, REM, 1 hit
cd00160, RhoGEF, 1 hit
Gene3Di1.10.840.10, 1 hit
1.20.900.10, 1 hit
2.30.29.30, 2 hits
InterProiView protein in InterPro
IPR035899, DBL_dom_sf
IPR000219, DH-domain
IPR001331, GDS_CDC24_CS
IPR000048, IQ_motif_EF-hand-BS
IPR011993, PH-like_dom_sf
IPR001849, PH_domain
IPR008937, Ras-like_GEF
IPR000651, Ras-like_Gua-exchang_fac_N
IPR019804, Ras_G-nucl-exch_fac_CS
IPR023578, Ras_GEF_dom_sf
IPR001895, RASGEF_cat_dom
IPR036964, RASGEF_cat_dom_sf
IPR030745, RasGRF1
PANTHERiPTHR23113, PTHR23113, 1 hit
PTHR23113:SF193, PTHR23113:SF193, 1 hit
PfamiView protein in Pfam
PF00169, PH, 2 hits
PF00617, RasGEF, 1 hit
PF00618, RasGEF_N, 1 hit
PF00621, RhoGEF, 1 hit
SMARTiView protein in SMART
SM00233, PH, 2 hits
SM00147, RasGEF, 1 hit
SM00229, RasGEFN, 2 hits
SM00325, RhoGEF, 1 hit
SUPFAMiSSF48065, SSF48065, 1 hit
SSF48366, SSF48366, 1 hit
PROSITEiView protein in PROSITE
PS00741, DH_1, 1 hit
PS50010, DH_2, 1 hit
PS50096, IQ, 1 hit
PS50003, PH_DOMAIN, 2 hits
PS00720, RASGEF, 1 hit
PS50009, RASGEF_CAT, 1 hit
PS50212, RASGEF_NTER, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRGRF1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q13972
Secondary accession number(s): F8VPA5
, H0YKF2, J3KQP9, Q16027
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: April 16, 2014
Last modified: February 23, 2022
This is version 201 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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